Dissertations / Theses on the topic 'SAPK'
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Girardin, Stephen. "Régulation de la voie de signalisation intracellulaire JNK/SAPK." Université Louis Pasteur (Strasbourg) (1971-2008), 2001. http://www.theses.fr/2001STR13179.
Full textCarbonell, Núñez Caterina 1987. "Regulation of alternative splicing by the p38 SAPK in response to stress." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/664502.
Full textLes cèl·lules tenen l'habilitat de detectar i respondre a les fluctuacions en el seu entorn a través de l'activació de les proteïnes quinasa activades per estrès (SAPKs). L'activació de la SAPK p38 és essencial per activar el programa d'expressió gènica necessari perquè les cèl·lules s’adaptin als estímuls extracel·lulars. El processament alternatiu del pre-ARNm és un mecanisme de regulació gènica crucial que es regula en resposta a diferents canvis en l'ambient. No obstant, els mecanismes moleculars pels quals es regula, així com la funció de les diferents isoformes de les proteïnes que s'expressen en resposta a estrès no es coneixen. En conjunt, els resultats presentats en aquesta tesis proporcionen una nova visió dels mecanismes pels quals p38 modula el processament alternatiu del pre-ARNm en resposta a estrès i posen en evidència la importància d'aquest mecanisme per l'adaptació de la cèl·lula a canvis en l'ambient extracel·lular.
Bellini, Angela. "Rôle des voies de réponse au stress dans le maintien de la stabilité génomique chez la levure Schizosaccharomyces pombe." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T048/document.
Full textGenomes are routinely submitted to injuries from either endogenous stress (oxidative stress, DNA replication block…) or from exogenous sources (radiations, chemicals, heavy metals…). The DNA damage response (DDR) coordinates a network of pathways including cell cycle checkpoints, DNA replication/repair/recombination, and programmed cell death, ensuring faithful genome transmission and preventing from the proliferation of cells bearing genetic alterations. Defect in one of these pathways generally results in altered sensitivity to genotoxins, genetic instability and cancer predisposition. Homologous recombination (HR) is an essential DNA repair pathway playing pivotal role to maintain genome stability.Oxidative stress, resulting from increased intracellular concentration of ROS, is one of the major causes of lipid, protein and DNA damage, and therefore a challenge for cell survival and genome stability. ROS are generated physiologically as by-products of cellular respiration, or as result of environmental stresses, such as exposure to solar UV radiations or to oxidant chemicals, and they actively participate in processes such as cellular growth, protein activity and folding, senescence and programmed cell death. It is noteworthy that an altered redox homeostasis is often associated to abnormally functioning cells, such as cancer and senescent cells. The aim of this project was to study the interface between two major evolutionarily conserved pathways, DDR and SAPK (Stress activated protein kinase) and the consequences on genome stability using fission yeast as a model organism. We report data showing that SAPK pathway impinges on HR by promoting phosphorylation of Rad52, a key protein involved in all sub-pathways of HR. We also revealed that Rad52 is phosphorylated at multiple different sites some of which are substrate for unidentified kinases unrelated to the SAPK pathway. Rad52 phosphorylation occurs either after oxidative stress or in cells genetically prone to HR perturbation. We identified two sites of phosphorylation, one of which is dependent on functional SAPK pathway. By studying Rad52 phosphorylation in cells mutated in the SAPK pathway or mutated at the Rad52 site of phosphorylation, we showed that HR is modulated by SAPK even in the absence of external insults. Our work pave the way to a novel understanding of fundamental mechanisms required for genome integrity maintenance
Krestow, Julia Katherine Ellen. "Functional dissociation of SAPK and apoptosis in epithelial and endothelial cells, implications for anoikis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0026/MQ50416.pdf.
Full textICHIKAWA, KENJI, TAKANORI NAKAMURA, YUJI KUBOTA, and MUTSUHIRO TAKEKAWA. "REGULATION OF STRESS-ACTIVATED MAP KINASE PATHWAYS DURING CELL FATE DECISIONS." Nagoya University School of Medicine, 2011. http://hdl.handle.net/2237/14910.
Full textBöhm, Markus. "Klonierung, Charakterisierung und Funktion der beiden SAPK-Mitglieder JNK und p38 MAPK des marinen Schwamms S. domuncula." [S.l. : s.n.], 2001. http://ArchiMeD.uni-mainz.de/pub/2002/0019/diss.pdf.
Full textAdrover, Nadal Miguel Angel. "Qualitative and quantitative study of the effect of osmotress on cell cycle of Saccharomyces cerevisiae." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7211.
Full textEl control del cicle cel·lular per Proteïna Cinases Activades per Estrès (SAPKs) es un aspecte essencial per a l'adaptació als estímuls extracel·lulars. A Saccharomyces cerevisiae, l'activació de la SAPK Hog1, resulta en un retardament de la transcripció de les ciclines de G1 (CLN1,2) i l'estabilització del inhibidor de les ciclines del tipus B, SIC1, i per tant posposa l'entrada en fase S. Els resultats que aquí s'exposen, mostren, mitjançant la combinació de modelatge matemàtic i experiments quantitatius in vivo, que, abans d'Start, el control de la transició es duu a terme principalment inhibint l'expressió de les ciclines, tant les de G1 (CLN1,2) com les de la fase S (CLB5,6). Per altra banda, després d'Start, la fosforilació i estabilització de Sic1 per part de Hog1 esdevé un fet necessari per a prevenir la iniciació de la replicació abans d'adaptar-se. Per tant, hem descobert aquí que la regulació de Sic1 i les ciclines juguen un paper diferent segons el moment en que apareix l'estrès. Hem descrit també, que Hog1 produeix una parada a G2 a través de la inhibició de la transcripció de CLB2 i la fosforilació d'Hsl1, la qual promou la deslocalització d'Hsl7 i la subsegüent estabilització de Swe1, un inhibidor específic de Clb1,2-Cdc28, i d'aquesta manera es posposa l'entrada en Anafase. Tot plegat, demostra que l'ús d'aproximacions pròpies de la Biologia de Sistemes és útil per a entendre de quina forma una via de senyalització intracel·lular incideix sobre el control del cicle cel·lular, mes enllà de la pura descripció de la mecànica del sistema. D'aquesta forma, proposem que una sola MAPK modula distints punts de control del cicle cel·lular per millorar la probabilitat de supervivència en front de l'estrès osmòtic.
Schroder, Wayne Ashley. "Cloning and Characterisation of the Human SinRIP Proteins." Thesis, Griffith University, 2003. http://hdl.handle.net/10072/366190.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
Faculty of Science
Full Text
Helbig, Lars [Verfasser]. "Aktivierung von c-Jun-N-terminalen Kinasen (SAPK,JNK) als Teil der späten Cisplatin abhängigen DNA-Schadensantwort / Lars Helbig." Mainz : Universitätsbibliothek Mainz, 2013. http://d-nb.info/1034965247/34.
Full textWang, Shu-Zong. "Cloning and characterization of SAPK interacting protein 1 (SIN1), a type 1 IFN receptor subunit 2 (IFNAR2)-interacting protein /." Free to MU Campus, others may purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3137761.
Full textLindner, Fabian Michael [Verfasser]. "Die Bedeutung von Stress-aktivierten Proteinkinasen (SAPK) nach 6-Hydroxydopamin-induzierter Apoptose in SH-SY5Y-Zellen / Fabian Michael Lindner." Kiel : Universitätsbibliothek Kiel, 2010. http://d-nb.info/1020001151/34.
Full textSchroder, Wayne Ashley, and n/a. "Cloning and Characterisation of the Human SinRIP Proteins." Griffith University. School of Biomolecular and Biomedical Science, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030829.140754.
Full textBlosser, Wayne D. "Colchicine and paclitaxel initiate apoptosis in IAR 20 rat hepatocytes through SAPK/JNK and caspase-3 activation via time dependent and p53 independent mechanisms." Virtual Press, 2002. http://liblink.bsu.edu/uhtbin/catkey/1248307.
Full textDepartment of Biology
池田, 篤史. "JNK/SAPK経路を活性化する新規プロテインキナーゼLZKによる細胞内シグナルの伝達の解析." 京都大学 (Kyoto University), 2001. http://hdl.handle.net/2433/73168.
Full textCloonan, Nicole, and N/A. "Sin1 and Sin1 Isoforms: An Investigation into the Biological Significance of a Novel Human Protein Family." Griffith University. School of Biomolecular and Biomedical Science, 2006. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20071102.150237.
Full textCloonan, Nicole. "Sin1 and Sin1 Isoforms: An Investigation into the Biological Significance of a Novel Human Protein Family." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/367210.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
Full Text
Fries, Florian [Verfasser], and Claus [Akademischer Betreuer] Schäfer. "Die Caerulein-induzierte akute Pankreatitis am Mausmodell : Auswirkung auf die Inflammation nach Hemmung der SAPK/JNK MAP-Kinase in nicht-transgenen und MK-2 -/- Mäusen / Florian Fries ; Betreuer: Claus Schäfer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1166559661/34.
Full textBarbosa, Amir Horiquini. "Avaliação de fatores de virulência e sensibilidade a antissépticos bucais de espécies de Candida isoladas da saliva de pacientes com próteses bucais." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-02102015-161413/.
Full textCandida species are opportunistic pathogens and infections in the oral cavity caused by these yeasts are common in patients with predisposing factors, such as diabetic or immunocompromised individuals with dental prosthesis. In Brazil, the number of toothless patients is high and the use of dental prosthesis is common, which represents a niche for colonization and formation of microbial biofilms in the oral cavity. The use of mouthwashes to aid in the oral hygiene has increased. The objective of this research was to isolate C. albicans and C. non-albicans from saliva of dental prosthesis users and to evaluate the isolates for the presence of virulence factors, proteinase production, biofilm formation and to search for genes encoding for proteinases (SAP1, SAP3) and adhesion factors (ALS1 and ALS3). Another objective was to evaluate in vitro the antifungal activity of three commercial mouthwashes containing 0.12% chlorhexidine and 0.07% or 0.075% cetylpyridinium, against planktonic Candida sp. cultures and in biofilms. Saliva samples of 70 patients with dental prosthesis were collected, the yeasts were isolated on CHOMagar® Candida and identified by classical biochemical tests combined with molecular test (PCR) for confirmation of C. albicans. Yeasts of Candida genus were isolated from 32 samples (45.7%) and were identified as C. albicans (29), C. krusei (5), C. glabrata (4), C. tropicalis (3) and C. parapsilosis (2), with a total of 43 yeasts, including mono and mixed cultures. The genes studied were detected only in C. albicans: ALS2, ALS3 and SAP3 genes were detected in 86% of the isolates and SAP1 in 93%. The proteinase activity among the isolates of C. albicans was 72.4% and among the species of C. non-albicans it was 35.7%. Assay done with cultivation in 96-wells microplates and staining with XTT, showed the majority of Candida isolates and all the mixed cultures were able to form biofilms within 24h. The activity of the three mouthwashes towards the yeasts was < 1.25%, equivalent to a dilution of 1:80 of the formulation. The three mouthwashes tested were also active against mono or multispecies biofilms. In conclusion, it was shown C. albicans is the most prevalent species. The genes SAP1, SAP3, ALS2 and ALS3 are present in the majority of C. albicans isolates, which were also positive for proteinase and biofilm formation. There was more proteinase activity in C. albicans in comparison with C. non-albicans. The biofilms of Candida species grew better in mixed cultures than in monoculture. The three commercial mouthwashes formulations were effective against all the yeast isolates in planktonic growth and they also inhibited the majority of yeasts in biofilm. Future work is needed to completely elucidate the role of Candida species in biofilms of oral cavity. It is also interesting to propose studies to standardize sensitivity tests for mono and multi-species biofilms.
Ferreiro, Neira Isabel. "Transcriptional regulation by the mammalian stress-activated protein kinase p38." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/80661.
Full textLa regulación de la transcripción por las Proteínas Quinasas activadas por Estrés (SAPKs) es un aspecto esencial para la adaptación a los estímulos extracelulares. En mamíferos, la activación de la SAPK p38 da lugar a la regulación de la expresión génica a través de la fosforilación de varios factores de transcripción. Sin embargo, cómo p38 SAPK regula el programa de expresión génica de adaptación al estrés así como los mecanismos utilizados por la SAPK permanece sin caracterizar. Los resultados presentados en este manuscrito muestran que p38 SAPK juega un rol central en la regulación de la expresión génica en respuesta a estrés, ya que hasta el 80% de los genes inducidos son dependientes de p38 SAPK. También observamos que en respuesta a cada tipo de estrés se induce un grupo de genes específicos, y sólo hay una pequeña respuesta de genes comunes a los diferentes tipos de estrés la cual engloba principalmente factores de transcripción. Además, hemos observado que para regular la transcripción, p38 se recluta a los promotores de respuesta a estrés a través de su interacción con factores de transcripción. Asimismo, la actividad de p38 permite el reclutamiento de la RNA Polimerasa II y de la MAPKK MKK6 a los promotores inducidos por estrés. La presencia de p38 activa en las regiones codificantes sugiere su participación durante la elongación. En conjunto, los resultados mostrados en este manuscrito establecen a p38 como un regulador esencial de la transcripción en respuesta a estrés, así como definen nuevas funciones de p38 en la regulación de la transcripción en respuesta a estrés.
Branco, Sílvia de Jesus Pereira Alegre. "SAPE." Master's thesis, [s.n.], 2011. http://hdl.handle.net/10400.26/16159.
Full textZapater, Enrique Meritxell. "Control of transcription initiation by the stress activated hog1 kinase." Doctoral thesis, Universitat Pompeu Fabra, 2006. http://hdl.handle.net/10803/7149.
Full textIn Saccharomyces cerevisiae, changes in the extracellular osmotic conditions are sensed by the HOG MAPK pathway, which elicits the program for cell adaptation, including modulation of gene expression, translation and cell-cycle progression. At the beginning of this PhD Project, the mechanisms by which Hog1 was controlling gene transcription were not completely understood. Our main objective was to characterize the molecular mechanisms by which the Hog1 MAPK modulates transcription upon osmostress. We have shown that anchoring of Hog1 to osmoresponsive promoters by the transcription factor is essential for recruitment and activation of RNA polymerase II, a mechanism that might be conserved among eukaryotic cells. In addition, we identified novel chromatin modifying and remodelling activities involved in the Hog1-mediated osmostress gene expression. We performed a genome-wide genetic screening searching for mutations that render cells osmosensitive and displayed reduced expression of osmoresponsive genes. Rpd3 histone deacetylase, SAGA and Mediator complexes were identified as novel regulators of osmostress-mediated transcription. Thus, our results define a major role for Rpd3, SAGA and Mediator in the Hog1-mediated osmostress gene induction, and have been important to achieve a better view of how a SAPK regulates transcription initiation.
OLIVER, Josidel Conceição. "Análise da expressão gênica diferencial de aspartato proteases secretadas (SAP2 e SAP4) por Candida albicans exposta a concentrações subinibitórias de antifúngicos e contato com macrófagos." Universidade Federal de Alfenas, 2016. https://bdtd.unifal-mg.edu.br:8443/handle/tede/960.
Full textFungal infections have become a major public health problem especially in hospital settings. Candida spp. are considered the main pathogen in invasive fungal infections. The production of secreted aspartic proteinases (Sapp) by Candida spp. can be related to the increase in the number of infections and drug resistance. The production of proteinases is encoded by a family of 10 genes known as SAP1-10, of which, SAP2 is the most commonly expressed gene in Candida albicans. The expression of SAP4-6 is associated to the production of Sap4-6p enzymes and hyphae formation which can contribute to the invasion of host tissues and destruction of macrophages during infectious processes. This study evaluates SAP2 and SAP4 gene expression in C. albicans ATCC 10231 grown in the presence or absence of macrophages and exposed to subinibitory concentrations of fluconazole and amphotericin B. C. albicans was grown in Sabouraud Dextrose Agar for 24 h at 37ºC and after in yeast carbon base more 0.2% bovine serum albumin (YCB-BSA) in the absence or presence of subinibitory concentrations of Fluconazole and Amphotericin B. The human monocytic leukemia cell line (THP-1) was grown in RPMI-1640 Medium supplemented with 10% fetal bovine serum, penicillin (100U/ml) and streptomycin (100μg/ml) at 37 °C and atmosphere of 5% CO2 during 10 days. For the induction of cell differentiation, 106 cells were seeded in RPMI-1640 medium supplemented and phorbol 12-myristate 13-acetate (PMA) 100 nM for 48 h. The samples of 5x106 C. albicans were cultured in the presence or absence of 106 macrophages and these was exposed or not to subinibitory concentrations of antifungals. All samples were incubated in culture test plates with 6 flat-botton wells for 1 h at 37 °C and atmosphere of 5% CO2. Total RNA was extracted from the samples using TRIzol® reagent, after RNA purification with DNaseI it was converted to cDNA, and then, the relative quantification of the SAP4 gene was performed by Real-Time Polymerase Chain Reaction (qPCR) using ACT1 gene as normalizing endogenous gene. Candida albicans grown in the presence of macrophages showed upregulation in the expression of SAP2 and SAP4 (p < 0.01), respectively, in the order of 4.83 and 10.34 fold higher as compared to yeast samples grown without contact with macrophages. Concerning exposure to antifungal agents, C. albicans exposed to subinhibitory concentrations of amphotericin B showed downregulation in expression of SAP2 and SAP4. However, the yeast's exposure to subinhibitory concentrations of fluconazole caused upregulation in SAP2 expression and downregulation in SAP4 expression. SAP2 and SAP4 genes are related to virulence factors of C. albicans and its expression can be regulated by contact with phagocytes or exposure to antifungals. Therefore, understanding the expression of these genes in fungal pathogenesis may aid in research and development of new drugs for treating candidiasis, thus contributing to reducing the incidence of morbidity and mortality associated with fungal infections.
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
Everton, Wilma. "SAPS members' experience of diversity and diversity training within the SAPS." Thesis, Rhodes University, 1999. http://hdl.handle.net/10962/d1002482.
Full textChovanec, Marek. "Integrace SAP Business Warehouse do ERP systému SAP." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2020. http://www.nusl.cz/ntk/nusl-417680.
Full textTavares, Carlos. "Data Warehouse & Business Intelligence SAPA: sistema de atribuição de produtos de apoio - SAPA." Master's thesis, Instituto Politécnico de Setúbal. Escola Superior de Tecnologia de Setúbal, 2017. http://hdl.handle.net/10400.26/19734.
Full textA entidade gestora do sistema de atribuição de produtos de apoio, o Instituto Nacional para Reabilitação, identificou a necessidade de possuir uma ferramenta que permita efetuar análises e extrair diversa informação estatística sobre os processos de atribuição de qualquer produto, instrumento, equipamento, tecnologia e software usado por uma pessoa com deficiência, vulgo, produtos de apoio. O presente projeto é a concretização do acima referenciado, desenvolvimento de um Data Warehouse e de relatórios, como uma ferramenta de Business Intelligence. Inicialmente foi efetuado um estudo aprofundado das regras do processo de negócio e do modelo relacional, que suporta o sistema de gestão de base de dados operacionais. Foram efetuadas várias reuniões com os representantes da entidade gestora e um estudo dos requisitos do projeto, através da criação de queries ao sistema fonte de dados. Após refinamento dos requisitos da informação estatística e conclusão da fase de análise, que inclui-o atividades como identificação de fontes, destino de dados e modelização, foi desenvolvido o Data Warehouse. Trabalho envolvendo os inerentes processos de extração, transformação e carregamento, seguido dos testes, automatização de processos e colocação em produção. O Data Warehouse, desenvolvido permitiu concretizar a implementação da infraestrutura de análise, efetuado com a ferramenta de Business Intelligence e assim atingir o objetivo final, possuir informação estatística, atualizada e precisa.
The managing body responsible for allocating disability equipment, the National Institute for Rehabilitation (Instituto Nacional para Reabilitação), has identified the need for a tool that allows the analysis and extraction of all the statistical information related to the process of granting disability equipment. In order to achieve this objective, the current project developed a Data Warehouse and reporting system using a Business Intelligence tool. The first step was to conduct an in-depth study focusing on the business process rules, and the relational model that supports the database management system. In order to determine the project’s requirements, various meetings were held with the representatives of the managing body, as well as data source queries. The Data Warehouse was created after refining the requirements of the statistical information and the completion of the analysis step, which included tasks such as source identification, data destination, and model-building. This involved the extraction, transformation and loading of the data, which was followed by testing, process automation, and the production stage. After loading the Data Warehouse, the data is organised in a way that allows the deployment of the analysis infrastructure, via the Business Intelligence tool, in order to achieve the final goal – to have updated and accurate statistical information.
Martins, Gesley Alex Veloso 1980. "Transformações na interface : SAPO-44." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250397.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica
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Mestrado
Quimica Inorganica
Mestre em Química
Koziczynski, Jakob, and Márcia Hammarström. "SEGMENTATION AND CUSTOMER RELATIONSHIPS AT SAPA." Thesis, Mälardalens högskola, Industriell ekonomi och organisation, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-28372.
Full textSplith, Tobias, Christian Chmelik, Frank Stallmach, Stefan K. Henninger, Gerrit Füldner, Panagiotis D. Kolokathis, Evangelia Pantatosaki, and George K. Papadopoulos. "Adsorptive heat transformation with SAPO-34." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-198701.
Full textWalther, Anne [Verfasser], Ulrich [Akademischer Betreuer] Sack, and Ulrich [Gutachter] Sack. "Proinflammatorische Zytokinantwort beim Neugeborenen nach Tabakrauchexposition während der Schwangerschaft / Anne Walther ; Gutachter: Ulrich Sack ; Betreuer: Ulrich Sack." Leipzig : Universitätsbibliothek Leipzig, 2013. http://d-nb.info/1238366333/34.
Full textSkolek, Ivo. "Integrace vybraných business procesů systému SAP CRM do systému SAP IS-U." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2013. http://www.nusl.cz/ntk/nusl-412881.
Full textKahan, Lina [Verfasser], Martin [Akademischer Betreuer] Sack, and Peter [Akademischer Betreuer] Henningsen. "Optimierung eines interventionellen Gruppenangebots zur Förderung von Ressourcen / Lina Kahan. Gutachter: Martin Sack ; Peter Henningsen. Betreuer: Martin Sack." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/1034420801/34.
Full textKahan, Lina Verfasser], Martin [Akademischer Betreuer] [Sack, and Peter [Akademischer Betreuer] Henningsen. "Optimierung eines interventionellen Gruppenangebots zur Förderung von Ressourcen / Lina Kahan. Gutachter: Martin Sack ; Peter Henningsen. Betreuer: Martin Sack." München : Universitätsbibliothek der TU München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20130321-1099150-0-8.
Full textAlves, Firmino André dos Santo. "Sistema de recomendações no SAPO Campus: desenvolvimento e avaliação: estudo de caso do mecanismo implementado no SAPO Campus." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12312.
Full textCom o lançamento e utilização de novas ferramentas para contextos educativos que pretendem realçar a importância da comunicação e colaboração em ambientes de aprendizagem, surgem novos desafios que é necessário investigar para encontrar soluções adequadas. No caso deste estudo, procura-se compreender e encontrar soluções adequadas para a problemática da sobrecarga de informação que pode ocorrer num espaço em que todos os elementos de uma comunidade têm a possibilidade de partilhar conteúdo e comunicar entre si. Nestes contextos, é possível que a informação disponível possa atingir uma quantidade que o utilizador não tem a capacidade de assimilar na sua totalidade e, muitas vezes, originando que perca informação relevante para si. Uma possível solução para este desafio passa pela integração de sistemas de recomendação transversais a essas novas ferramentas, potenciando o seu desenvolvimento baseado no próprio utilizador e também na sua interação com a comunidade, promovendo o desenvolvimento de novas formas de partilha e de interação entre os utilizadores. Neste trabalho apresentam-se as principais etapas da conceção, desenvolvimento e avaliação da integração de um sistema de recomendações numa plataforma social para contexto educativo, o SAPO Campus.
With the advent of new educational tools for learning contexts with the purpose of highlighting the importance of communication and collaboration in learning environments, new challenges should be taken into account in order to discover proper solutions. With this investigation, we seek to understand and find a suitable approach to the information overload problem that can occur in places where all community members have the ability to communicate and share content. It is possible, in these contexts, for the available information to reach such an amount that the user will not have the ability to fully assimilate it, which often causes the loss of the track of data, which is importante to the user. A possible solution for this challenge implies the integration of transverse recommendation systems in these tools, enhancing their growth based on the user and his interaction with the community and promoting the emergence of new methods for him to share and interact with others. This study presents the main steps of the design, development and assessment of the process for integrating a recommendation system in SAPO Campus, a social platform for the educational context.
Třeštíková, Lenka. "Bezpečnostní metriky platformy SAP." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2017. http://www.nusl.cz/ntk/nusl-363799.
Full textVaculíková, Michaela. "Marketingová strategie společnosti SAP." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-71886.
Full textVaníková, Zuzana. "Společenská odpovědnost firmy SAP." Master's thesis, Vysoká škola ekonomická v Praze, 2015. http://www.nusl.cz/ntk/nusl-261760.
Full textMcCarthy, Charlton Shamus. "Strategies for promoting ethics within the SAPS." Thesis, Nelson Mandela Metropolitan University, 2014. http://hdl.handle.net/10948/8553.
Full textKoch-Grünberg, Tim Theodor. "Gameful connectivism: social bookmarking no SAPO Campus." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7506.
Full textA web moderna, ou web 2.0, assenta nos princípios de abertura e participação dos seus utilizadores. A natureza voluntária do uso de serviços da web 2.0, aliada à dependência da participação por parte dos seus utilizadores, leva a uma forte concorrência entre serviços semelhantes na web. Esta concorrência leva à procura de novas formas de diferenciação entre serviços. Neste contexto surge a indústria de gamification, que procura transferir elementos de videojogos a outros contextos para aumentar o envolvimento dos utilizadores. Contudo, o discurso desta indústria recente é alvo de fortes críticas de profissionais de game design. Neste trabalho de investigação apresenta-se tanto o discurso da indústria de gamification como as suas críticas. Assumindo que a abordagem atual da gamification assenta numa compreensão limitada dos videojogos, parte-se para a elaboração de um novo quadro concetual que possa guiar o desenho da interação em ambientes web. Esta abordagem fundamenta-se num levantamento bibliográfico da teoria do game design. O quadro concetual resultante é usado no desenho e desenvolvimento de um serviço de social bookmarking no Sapo Campus UA, uma plataforma de serviços web 2.0 para contextos educativos, com o objetivo explícito de aumentar a participação dos seus utilizadores na aplicação. A utilidade do quadro concetual é avaliada com sessões de teste com utilizadores do público-alvo do serviço. Os resultados obtidos indicam que o game design pode enriquecer o desenho da interação na web através da criação de ciclos de ação com resultado claro e feedback positivo.
The modern web, or web 2.0, is centred on the principles of openness and user participation. The voluntary use of web 2.0 services, together with the dependency on user participation, results in a strong competition. This situation gave rise to the gamification industry, which aims to bring elements of video games to other contexts in order to increase user engagement. However, professional game designers strongly criticize the discourse of this young industry. This dissertation presents the gamification industry's discourse and its major critics. Assuming that the current approach to gamification only holds a limited understanding of videogames, we seek to build a new conceptual model to be used in web interaction design. This approach is based in a review of game design literature. The resulting conceptual model is used in the design and development of a social bookmarking service for the Sapo Campus UA project, a web 2.0 platform for higher education, with the specific goal of increasing user participation. The modelʼs usefulness is evaluated through user tests with potential future users. The results of this study indicate that game design can assist web interaction design in the creation of user activity cycles with clear results and positive feedback.
Wade, Kevin Christopher. "SARK : a type-insensitive Runge-Kutta code." Thesis, University of Greenwich, 1987. http://gala.gre.ac.uk/8709/.
Full textSchrimpf, Petra [Verfasser], Dorothée [Akademischer Betreuer] Sack, Detlef [Akademischer Betreuer] Liesegang, Dorothée [Gutachter] Sack, and Detlef [Gutachter] Liesegang. "Untersuchungen zum denkmalverträglichen Feuchteschutz bei sommerlicher Kondensation in Kirchen / Petra Schrimpf ; Gutachter: Dorothée Sack, Detlef Liesegang ; Dorothée Sack, Detlef Liesegang." Berlin : Technische Universität Berlin, 2017. http://d-nb.info/1156180589/34.
Full textHeger, Sinja-Anouk [Verfasser], Martin [Akademischer Betreuer] Sack, Martin [Gutachter] Sack, and Peter [Gutachter] Henningsen. "Wirkfaktoren der EMDR-Behandlung: Stimulationsart, EEG und periphere Physiologie / Sinja-Anouk Heger ; Gutachter: Martin Sack, Peter Henningsen ; Betreuer: Martin Sack." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1149824158/34.
Full textSaliba, John Keith. "Hayes, Herr and Sack Esquire goes to Vietnam /." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0011425.
Full textWittesjö, Viktor, and Joakim Thörne. "Vidareutveckling av skrotfallsprognos : på Sapa Heat Transfer AB." Thesis, Linköping University, Production Economics, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-53896.
Full textSapa Heat Transfer AB (SHT AB) är en av tre delar inom koncernen Sapa Group, som ägs av det norska företaget Orkla ASA. SHT AB har produktion både i Sverige (Finspång) och i Kina (Shanghai). Företaget är en världsledande leverantör och utvecklare av aluminiumband som används i olika typer av värmeväxlare, främst inom bilindustrin.
I flera steg av produktionen, som innefattar omsmältning, varm- och kallvalsning samt skärning, uppkommer ett skrotfall av aluminium. Detta skrot tas omhand och återanvänds som råvara i företagets omsmältverk. SHT AB har idag inget automatiserat IT-stöd för att prognostisera skrotavfallet, dessa beräkningar görs istället med hjälp av Excel. Då skrotfallet beräknas används ett schablonvärde för processens utbyte, som motsvarar genomsnittet för samtliga legeringskombinationer i produktion. Eftersom ett medelvärde används blir prognosen missvisande för vissa legeringar. Detta då utbytet varierar mycket, vilket gör att det både finns de legeringskombinationer som har betydligt högre utbyte än genomsnittet och de som har betydligt lägre. SHT AB har idag inte heller någon koppling mellan faktisk orderstock och kortsiktig prognostisering av skrotfall.
Syftet med detta examensarbete är att ta fram förslag på hur Sapa Heat Transfer AB kan och bör utveckla sin prognostisering av skrotfall. Därigenom ska Sapa Heat Transfer AB få bättre precision i både långsiktig och kortsiktig skrotfallsprognos, och på så vis förbättra råvaruplaneringen.
För att förbättra den långsiktiga skrotfallsprognosen måste nedbrytningen av prognosen för legeringskombinationer analyseras. En förbättring av nedbrytningen förväntas innebära en förbättrad långsiktig prognos. Förbättrad innebär i detta fall att skrotfallsprognosen bättre ska följa den långsiktiga prognosen för försäljning av legeringskombinationer. Precisionen hos skrotfallsprognosen blir givetvis beroende av precisionen hos denna prognos. En förändring av nedbrytningen medför dock att kapacitetsplaneringen för omsmältverkets ugnar påverkas.
Åtgärdsförslaget som tas fram för den långsiktiga prognostiseringen är tänkt att förbättra denna genom att schablonvärdet som används ersätts med varje legeringskombinations specifika prognostiserade utbyte. Data som behövs för att genomföra en sådan prognos finns tillgänglig i SHT AB:s databaser, och med hjälp av prognostiseringsmetoden exponentiell utjämning kan utbytet prognostiseras. Genom att använda denna metod med ett lågt värde på utjämningskonstanten α, fås en prognos där extremvärden inte ger kraftiga utslag på prognosen.
Den kortsiktiga skrotfallsprognosen, som idag bygger på en nedbrytning av den långsiktiga prognosen, kan förbättras genom att istället kopplas till den faktiska orderstocken. Om denna koppling görs baseras skrotfallsprognosen mer på känd information istället för på en annan prognos. En koppling till orderstocken kan dock bara användas för kortsiktig skrotfallsprognostisering då orderstocken inte sträcker sig flera månader framåt.
Åtgärdsförslaget som tas fram för den kortsiktiga skrotfallsprognosen utgår från att en schablonmässig prognos först tas fram för de skrotgrupper som ska prognostiseras. I denna används en individuell prognostiserad skrotfallsfaktor som tas fram med exponentiell utjämning för respektive skrotgrupp. Skrotfallsfaktorn är baserad på historisk data för planerat material in till processen och invägt skrot till smältverket. Med hjälp av skrotfallsfaktorn, data för hur mycket material som är planerade in i processen kommande veckor och med hänsyn till att skrot faller under hela ledtiden, kan ett förväntat skrotfall för kommande vecka/veckor beräknas.
För att få en bättre precision än hos den schablonmässiga prognosen, kan sedan prognosen för de skrotgrupper som är mest intressanta utvecklas och anpassas. De kan ges individuella värden på utjämningskonstanten α för prognostiseringen av skrotfallsfaktor och även sättet som hänsyn till ledtid tas kan anpassas. I förslaget har förenklingen gjorts att skrot väntas falla symmetriskt över ledtiden vilket inte stämmer helt med verkligheten. Därför bör prognosen också utvecklas så att hänsyn tas till att det exempelvis faller förhållandevis mycket skrot i slutet av ledtiden.
Sapa Heat Transfer AB (SHT AB) is one of three components in the corporate group Sapa Group, owned by the Norwegian company Orkla ASA. Sapa Heat Transfer AB has production in Sweden (Finspång) and China (Shanghai). The company is a world leading supplier and developer of aluminum strips used in various types of heat exchangers, primarily in the automotive industry.
In several stages of the production, which includes remelting, hot and cold milling and cutting, a part of the processed material becomes scrap metal. This scrap metal is collected and reused as raw material in the remelting factory. SHT AB currently has no automated IT support to forecasting this scrap metal; these calculations are, in the current situation, made with the help of Excel. In the calculation of scrap metal the company uses a standard value, corresponding to the average yield for all alloy combinations in the production. As a mean value is being used for all alloy combinations, the forecast becomes misleading for some alloys. The yield varies widely depending on the alloy, which means there are alloy combinations that are above the average yield and some that are below. In the current situation SHT AB has no link between actual orders and the short-term forecast of scrap metal.
The purpose of this thesis is to develop proposals on how Sapa Heat Transfer AB can and should develop its forecasting of scrap metal. This will help them getting a better accuracy in their forecasting and thereby improving the raw material planning.
In order to improve the long-term forecast of scrap metal the decomposition of the forecast for the alloy combination had to be analyzed. An improvement of the decomposition will mean an improvement of the precision for the long-term prognosis of scrap metal. A change in the decomposition will also influence the capacity planning in the remelting factory.
The action proposal for the long-term forecasting will result in a better accuracy of the forecast by replacing the mean value for the yield by a specific forecasted yield of each alloy combination. The data needed to carry through such a forecast is available in SHT AB´s databases, and by using the forecasting method exponential smoothing the yield can be forecasted. By using this method a forecast will be obtained that, with a low value of α, will not take such great impact from extreme values that sometimes occur.
The current short-term scrap metal forecast, based on a decomposition of the alloy combination forecast, can be improved by a link to the actual backlog. If this link is established the scrap metal forecast will be based on known information instead of forecasted data. A link to the backlog can only be used for a short-term forecast due to the length of the awaiting orders.
The action proposal to improve the short-term forecast assumes that a standardized forecast is developed for the scrap groups to be projected. The forecast should use an individually forecasted scrap factor produced with exponential smoothing for each scrap group. The scrap factor is based on historical data for the material planned to go into the process and the weighed scrap delivered to the remelting factory. With this scrap factor, data on how much material that is planned into the process the coming weeks and with consideration of scrap falling throughout the lead time the expected amount of scrap for the coming week / weeks can be calculated.
To get a better precision compared to the standardized forecasts, the forecasts of the most interesting scrap groups should be developed and adapted. They can be given individual values of the smoothing constant α for the prediction of the scrap factor and the way the lead time is being considered can be adjusted. In the proposal the simplification that scrap is expected to fall symmetrically distributed over the lead time has been done. In reality this is not the case. Therefore, the forecast should also be developed to take into account that, for example, more scrap is falling in the end of the lead time.
Persson, Nicklas, and Johan Stark. "Nyutveckling av bakdörrar vid Sapa Building System AB." Thesis, University of Kalmar, Department of Technology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-5799.
Full textSapa är en av de största tillverkarna i världen av aluminiumprofiler. Sapa Building System AB är ett dotterbolag till Sapa group och är en av de största leverantörerna i Europa på byggsystem. Några av deras produkter är bakdörrarna RD 3010 och RD 3020 för lastbilar, släp och trailers som från början var ämnade som sidodörrar. Som bakdörrar är de överdimensionerade då sidodörrar hade högre hållfasthetskrav. I dagens läge väger och kostar de mer än nödvändigt där av önskar Sapa Building System AB en nyutveckling av bakdörrarna.
Målet är att omkonstruera bakdörrarna RD 3010 och RD 3020 så att de blir lättare, smidigare och billigare genom att konstruera en ny kantskoning till Sapa Building System AB:s befintliga aluminiumlämprofiler.
Arbetet har resulterat i att ritningsunderlag för nya profiler har tagits fram där man valt att limma ihop dörrarnas delar istället för att nita. Detta kan i sin tur leda till att kostnad, vikt och ledtid reduceras.
Sapa is one of the three largest manufactures of aluminum profiles in the world. Sapa Building System AB is a subsidiary to Sapa group and is one of the largest suppliers of building systems in Europe. Some of their products are the rear doors RD 3010 and RD 3020 for trucks and trailers which were from the beginning meant as side doors. As rear doors they are over dimensioned because side doors have higher requirements. As there are no requirements today they weigh and cost more than necessary. Sapa Building System AB wants a new development of the rear doors.
The purpose with this work is to develop new aluminum profiles for the company’s rear doors so that cost, weight and assembly time is lowered.
One of the reasons that Sapa Building System AB could offer this thesis was that they considered it may be profitable to have outsiders develop their products, someone that does not have the “sapa-way-thinking” in their mind. A person that has a different perspective and a different angle of approach of the problem and can provide innovative solutions.
The goal is to reconstruct the rear doors RD 3010 and RD 3020 so that they will be lighter, easier to handle and cheaper by developing a new frame for the existing aluminum profiles that Sapa Building System AB has today.
As a result drawings for new profiles has been made where the doors is assembled with glue instead of using rivets. This may lead to a reduction of price, weight and assembly time.
Sapi, Geza [Verfasser]. "Three Essays on Industrial Organisation Theory / Geza Sapi." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2012. http://d-nb.info/1022195638/34.
Full textBooysen, Freddie. "Delft SAPS as an instrument for community development." Thesis, Stellenbosch : Stellenbosch University, 2005. http://hdl.handle.net/10019.1/20913.
Full textENGLISH ABSTRACT: This study was undertaken to determine whether a lack of effective service delivery at the South African Police Service at Delft was due to a lack of community participation and development in Delft. Data was collected through a plurality of research methodologies, including participatory action research by means of interviews with role players and participative observation; a literature study; a diachronical study, application of relevant legislation as a guideline as well as input gained by means of discussion with various experts. The collected data was analysed in relation to the theme, the objective of the study and the research hypothesis. The following observations were made as a result of the study: • The local police station SAPS Delft, by acting as a catalyst, has assisted in the establishment of many structures in the community; and • The erecting of a new police station facilitated community participation and development. The study, having considered the observations and drawn conclusions, has offered a number of recommendations namely: • The erecting of a new police station should take place simultaneously with the development of the township where it is situated. By this means all role players will participate. • The local government and relevant national government departments are of the utmost importance when it comes to addressing the root causes of the problems in the community or when putting alternatives in place. The location of a police station should be such that its convenience and accessibility will result in enhanced and sustainable service delivery, provided that the community capitalises on it. Finally, to ensure success, there must be education and training of both the police and the community, facilitated by the SAPS, government departments and NGOs.
AFRIKAANSE OPSOMMING: Die studie is onderneem om vas te stel of die gebrek aan effektiewe dienslewering by Delft Suid-Afrikaanse Polisie Diens te wyte is aan die gebrek aan gemeenskapsdeelname en -ontwikkeling in Delft. Data is ingesamel deur middel van ‘n pluraliteit van navorsingsmetodologië, insluitend die volgende: deelnemende aksie navorsing deur onderhoude met rol spelers en deelnemende waarneming; ‘n literatuurstudie; ‘n diakroniese studie, toepassing van relevante wetgewing as ‘n riglyn asook insae verkry deur besprekings met ‘n verskeidenheid kenners. Die ingesamelde data is geanaliseer in verhouding tot die tema en die doelwitte van die studie en is vergelyk met die navorsingshipotese. Die volgende waarnemings is uit die studie gemaak: • Die plaaslike polisiestasie, Delft SAPD, het as katalisator gedien om baie strukture in die gemeenskap tot stand te bring; en • Die oprigting van ‘n nuwe polisiestasie het gemeenskapsbetrokkenheid en - ontwikkeling gefasiliteer. Die waarnemings in ag geneem, is tot die gevolgtrekking gekom dat die volgende aanbevelings gemaak word: • Die bou van ‘n nuwe polisiestasie moet saam met die ontwikkeling van ‘n woonbuurt geskied, waarby alle rolspelers betrokke moet wees; en • Die plaaslike regering en relevante departemente is van kardinale belang by die aanspreek van die oorsake van probleme in gemeenskappe of om alternatiewe in plek te stel. Die aanwesigheid van ‘n bereikbare en toeganklike polisiekantoor sal beter en volhoubare dienslewering tot gevolg hê indien die gemeenskap daarop kapitaliseer. Laastens verg dit egter opvoeding, vir die polisie sowel as die gemeenskap, en gefasiliteer deur SAPD, staatsdepartemente en nie-regeringsorganisasies om sukses te verseker.
Wojton, Jeffrey Alan Jr. "SapC-DOPS Nanotherapy for the Treatment of Glioblastoma." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1395416721.
Full textFerreira, Maria de Fatima Gomes Pais. "SAPO campus: aprendizagem, ensino e pessoas em rede." Doctoral thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/15855.
Full textAs escolas portuguesas do ensino não superior estão dotadas com infraestruturas e equipamentos que permitem trazer o mundo para dentro da sala de aula, tornando o processo de ensino e de aprendizagem mais rico e motivador para os alunos. A adoção institucional de uma plataforma que segue os princípios da web social, o SAPO Campus (SC), definida pela abertura, partilha, integração, inovação e personalização, pode ser catalisadora de processos de mudança e inovação. O presente estudo teve como finalidade acompanhar o processo de adoção do SC em cinco escolas, bem como analisar o impacto no processo de ensino e de aprendizagem e a forma como os alunos e professores se relacionam com esta tecnologia. As escolas envolvidas foram divididas em dois grupos: o primeiro grupo, constituído por três escolas onde o acompanhamento teve uma natureza mais interventiva e presente, enquanto que no segundo grupo, composto por duas escolas, foram apenas observadas as dinâmicas que se desenvolveram no processo de adoção e utilização do SC. No presente estudo, que se assume como um estudo longitudinal de multicasos, foram aplicadas técnicas de tratamento de dados como a estatística descritiva, a análise de conteúdo e a Social Network Analysis (SNA), com o objetivo de, através de uma triangulação permanente, proceder a uma análise dos impactos observados pela utilização do SC. Estes impactos podem ser situados em três níveis diferentes: relativos à instituição, aos professores e aos alunos. Ao nível da adoção institucional de uma tecnologia, verificou-se que essa adoção passa uma mensagem a toda a organização e que, no caso do SC, apela à participação coletiva num ambiente aberto onde as hierarquias se dissipam. Verificou-se ainda que deve implicar o envolvimento dos alunos em atividades significativas e a adoção de estratégias dinâmicas, preferencialmente integradas num projeto mobilizador. A adoção do SC foi ainda catalisadora de dinâmicas que provocaram mudanças nos padrões de consumo e de produção de conteúdos bem como de uma atitude diferente perante o papel da web social no processo de ensino e aprendizagem. As conclusões apontam ainda no sentido da identificação de um conjunto de fatores, observados no estudo, que tiveram impacto no processo de adoção como o papel das lideranças, a importância da formação de professores, a cultura das escolas, a integração num projeto pedagógico e, a um nível mais primário, as questões do acesso à tecnologia. Algumas comunidades construídas à volta do SAPO Campus, envolvendo professores, alunos e a comunidade, evoluíram no sentido da autossustentação, num percurso de reflexão sobre as práticas pedagógicas e partilha de experiências.
Portuguese schools are currently fully equipped with resources and facilities that make it possible to bring the world into the classroom, thus enhancing both the teaching and learning dynamics, as well as increasing students’ motivation. The institutional adoption of platforms, such as SAPO Campus (SC), that follow the core principles of the social web, and are defined by openness, sharing, integration, innovation and personalization, can become the driving force for change and innovation within schools. This study’s main goal was to monitor how five different schools adopted and implemented the SC platform, as well as analyse its impact on the teaching and learning processes and how students and teachers responded to this technology. The schools included in this research were divided into two groups: the first group consisted of three schools in which there was a more direct and proactive intervention regarding the adoption and use of the platform, whereas the second group was made up of two schools in which these processes were only observed, without the direct involvement of researchers. Considering this was a longitudinal survey focusing on multiple cases, different data processing techniques, such as descriptive statistics, content analysis and Social Network Analysis (SNA) were used throughout the study. The data collected was then triangulated and validated making it possible to analyse the impact of SC and how it was used. These impacts can be placed at different levels: those concerning the institution, teachers and students. Regarding technology appropriation, at an institutional level the platform’s endorsement sends out a message to the organization, calling out for collective engagement and participation within an open environment, where hierarchies become less apparent. It also became clear that students must be engaged in significant activities, as the platform’s use strives when dynamic strategies are used, especially within the scope of stimulating projects. SC’s adoption was also a catalyst for dynamics that changed consumption and production patterns and fostered a different attitude towards the role social web plays in the teaching and learning process. The results also point towards several elements that were observed throughout the study as having had an impact in the platform’s adoption. These elements include the role of leaderships, the importance of teacher training, school culture, integration into a pedagogical project and, at a more basic level, questions regarding the access to technology. Some communities that emerged from and around SAPO Campus and that involved teachers, students and the community, have become self-sufficient, having based their growth on the reflection on pedagogical practices and the sharing of experiences.
Pönisch, Jens. "SAP R/3 und Linux." Universitätsbibliothek Chemnitz, 2001. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200100182.
Full textLiljeqvist, Björn. "StockholmsOperan, Galärvarvet : En smal sak." Thesis, KTH, Arkitektur, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-37316.
Full textGalarvarvet is in many ways an great site for a new and prominent cultural building in Stockholm. At the same time the complexity and size of the program of an opera poses a great challenge. In this project the conflict between program and site is solved with a stretched out building that preserves environmental values and movements.