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1
Roberts, Gareth O. Convergence of slice sampler Markov chains. [Toronto: University of Toronto, 1997.
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2
Liang, F. Advanced Markov chain Monte Carlo methods: Learning from past samples. Hoboken, NJ: Wiley, 2010.
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3
Christine, Murphy, ed. Chain of custody--recommendations for acceptance and analysis of evidentiary geochemical samples. Washington: U.S. G.P.O., 1997.
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4
1942-, Cooper J. David, Pikulski John J, O'Brien Anne Sibley, Gay Tanner Ottley, Yee Wong Herbert, Aardema Verna, Pape Donna Lugg, Bernard Robin, and Standiford Natalie, eds. Transitions in literacy: Sample materials. Boston: Houghton Mifflin, 1999.
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5
Stelzer, Erin A. Interlaboratory comparison of results for three microbial source tracking quantitative polymerase chain reaction (qPCR) assays from fecal-source and environmental samples. Reston, Va: U.S. Dept. of the Interior, U.S. Geological Survey, 2012.
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6
Vasterman, Peter, ed. From Media Hype to Twitter Storm. NL Amsterdam: Amsterdam University Press, 2018. http://dx.doi.org/10.5117/9789462982178.
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The word media hype is often used as rhetorical argument to dismiss waves of media attention as overblown, disproportional and exaggerated. But these explosive news waves, as well as - nowadays - the twitter storms, are object of scientific research, because they are an important phenomenon in the public area. Sometimes it is indeed 'much ado about nothing' but in many cases these media storms have play an important role in political issues, scandals and crises. Twitter storms sometimes ruin reputations within hours. Although different concepts are used, such as media hypes, news waves, media storms, information cascades or risk amplification, all the studies in this book refer to the same process in which key events trigger a chain of reactions and interactions, building up huge news waves in the media or rapidly spreading social epidemics in the social media. This book offers the first comprehensive overview of this important topic. It is not only interesting for scholars and students in media and journalism, but also for professionals in PR and communication, crisis communication and reputation management.
7
Bond, Primula. Silver Chain Free Sample. HarperCollins Publishers Limited, 2013.
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8
Build Your Playbook for Managing Supply Chain Transactions: WITH DESKTOP TOOLS, REFERENCES AND SAMPLE FORMS. X. Paul Humbert, 2015.
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9
Coolen, A. C. C., A. Annibale, and E. S. Roberts. Markov Chain Monte Carlo sampling of graphs. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198709893.003.0006.
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This chapter looks at Markov Chain Monte Carlo techniques to generate hard- and soft-constrained exponential random graph ensembles. The essence is to define a Markov chain based on ergodic randomization moves acting on a network with transition probabilities which satisfy detailed balance. This is sufficient to ensure that the Markov chain will sample from the ensemble with the desired probabilities. This chapter studies several commonly seen randomization move sets and carefully defines acceptance probabilities for a range of different ensembles using both the Metropolis–Hastings and the Glauber prescription. Particular care is paid to describe and avoid the pitfalls that can occur in defining randomization moves for hard-constrained ensembles, and applying them without introducing inadvertent bias (i.e. defining and comparing protocols including switch-and-hold and mobility).
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Carroll, Raymond, Faming Liang, and Chuanhai Liu. Advanced Markov Chain Monte Carlo Methods: Learning from Past Samples. Wiley & Sons, Incorporated, John, 2011.
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11
Carroll, Raymond, Faming Liang, and Chuanhai Liu. Advanced Markov Chain Monte Carlo Methods: Learning from Past Samples. Wiley & Sons, Incorporated, John, 2010.
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12
Carroll, Raymond, Faming Liang, and Chuanhai Liu. Advanced Markov Chain Monte Carlo Methods: Learning from Past Samples. Wiley & Sons, Limited, John, 2010.
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13
Carroll, Raymond, Faming Liang, and Chuanhai Liu. Advanced Markov Chain Monte Carlo Methods: Learning from Past Samples. Wiley & Sons, Incorporated, John, 2011.
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14
Coolen, A. C. C., A. Annibale, and E. S. Roberts. Graphs with hard constraints: further applications and extensions. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198709893.003.0007.
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This chapter looks at further topics pertaining to the effective use of Markov Chain Monte Carlo to sample from hard- and soft-constrained exponential random graph models. The chapter considers the question of how moves can be sampled efficiently without introducing unintended bias. It is shown mathematically and numerically that apparently very similar methods of picking out moves can give rise to significant differences in the average topology of the networks generated by the MCMC process. The general discussion in complemented with pseudocode in the relevant section of the Algorithms chapter, which explicitly sets out some accurate and practical move sampling approaches. The chapter also describes how the MCMC equilibrium probabilities can be purposely deformed to, for example, target desired correlations between degrees of connected nodes. The mathematical exposition is complemented with graphs showing the results of numerical simulations.
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Cheng, Russell. Finite Mixture Examples; MAPIS Details. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198505044.003.0018.
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Two detailed numerical examples are given in this chapter illustrating and comparing mainly the reversible jump Markov chain Monte Carlo (RJMCMC) and the maximum a posteriori/importance sampling (MAPIS) methods. The numerical examples are the well-known galaxy data set with sample size 82, and the Hidalgo stamp issues thickness data with sample size 485. A comparison is made of the estimates obtained by the RJMCMC and MAPIS methods for (i) the posterior k-distribution of the number of components, k, (ii) the predictive finite mixture distribution itself, and (iii) the posterior distributions of the component parameters and weights. The estimates obtained by MAPIS are shown to be more satisfactory and meaningful. Details are given of the practical implementation of MAPIS for five non-normal mixture models, namely: the extreme value, gamma, inverse Gaussian, lognormal, and Weibull. Mathematical details are also given of the acceptance-rejection importance sampling used in MAPIS.
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Laver, Michael, and Ernest Sergenti. Systematically Interrogating Agent-Based Models. Princeton University Press, 2017. http://dx.doi.org/10.23943/princeton/9780691139036.003.0004.
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This chapter develops the methods for designing, executing, and analyzing large suites of computer simulations that generate stable and replicable results. It starts with a discussion of the different methods of experimental design, such as grid sweeping and Monte Carlo parameterization. Next, it demonstrates how to calculate mean estimates of output variables of interest. It does so by first discussing stochastic processes, Markov Chain representations, and model burn-in. It focuses on three stochastic process representations: nonergodic deterministic processes that converge on a single state; nondeterministic stochastic processes for which a time average provides a representative estimate of the output variables; and nondeterministic stochastic processes for which a time average does not provide a representative estimate of the output variables. The estimation strategy employed depends on which stochastic process the simulation follows. Lastly, the chapter presents a set of diagnostic checks used to establish an appropriate sample size for the estimation of the means.
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White, P. Lewis, and Rosemary A. Barnes. Molecular diagnosis of fungal disease. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0043.
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Molecular techniques to aid in the diagnosis of fungal disease have been in use for over two decades. However, for polymerase chain reaction (PCR) to gain widespread acceptance outside of specialist centres, methodology must be standardized and in line with general microbiological molecular diagnostics assays, yet for infections other than fungal disease. Apart from Aspergillus PCR, standardized methodology is lacking. It is also essential to identify the optimal role for an assay. Whether this is to confirm a specific disease in symptomatic patients or to exclude disease and prevent the unnecessary use of antifungals will, in part, be determined by prevalence, but will also, along with the disease manifestation, dictate specimen choice and subsequent methodological procedure. This chapter will focus on disease processes determining optimal sample types, before concentrating on the clinical validation of molecular tests for the diagnosis of the main causes of invasive fungal disease, concluding with recent developments. The clinical utility of molecular approaches and potential future benefits that can address emerging issues, such as azole resistance, will also be discussed.
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van Moerbeke, Pierre. Determinantal point processes. Edited by Gernot Akemann, Jinho Baik, and Philippe Di Francesco. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780198744191.013.11.
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This article presents a list of algebraic, combinatorial, and analytic mechanisms that give rise to determinantal point processes. Determinantal point processes have been used in random matrix theory (RMT) since the early 1960s. As a separate class, determinantal processes were first used to model fermions in thermal equilibrium and the term ‘fermion’ point processes were adopted. The article first provides an overview of the generalities associated with determinantal point processes before discussing loop-free Markov chains, that is, the trajectories of the Markov chain do not pass through the same point twice almost surely. It then considers the measures given by products of determinants, namely, biorthogonal ensembles. An especially important subclass of biorthogonal ensembles consists of orthogonal polynomial ensembles. The article also describes L-ensembles, a general construction of determinantal point processes via the Fock space formalism, dimer models, uniform spanning trees, Hermitian correlation kernels, and Pfaffian point processes.
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Arjaliès, Diane-Laure, Philip Grant, Iain Hardie, Donald MacKenzie, and Ekaterina Svetlova. Bringing Society Back into the Investment Chain. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198802945.003.0006.
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Chapter 6 explores why fixed income managers inside a French asset management company refused to consider the repetitive alerts of Responsible Investing (RI) analysts regarding the solvency problems of Greece and Italy before such issues went public. By comparing the reactions of fixed income managers to the equity managers inside the same company, the chapter identifies the disconnect between the fixed income evaluation practices and the society as being the main explanatory factor of fixed income managers’ reluctance vis-à-vis RI analysts’ suggestions. Elaborating on these findings, the chapter suggests that different groups of actors along the investment chain might hold distinctive views on what the components of the investment chain are, depending on their evaluation cultures.
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Bertola, Marco. Chain of matrices, loop equations, and topological recursion. Edited by Gernot Akemann, Jinho Baik, and Philippe Di Francesco. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780198744191.013.16.
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This article considers the so-called loop equations satisfied by integrals over random matrices coupled in a chain as well as their recursive solution in the perturbative case when the matrices are Hermitian. Random matrices are used in fields such as the study of multi-orthogonal polynomials or the enumeration of discrete surfaces, both of which are based on the analysis of a matrix integral. However, this term can be confusing since the definition of a matrix integral in these two applications is not the same. The article discusses these two definitions, perturbative and non-perturbative, along with their relationship. It first provides an overview of a matrix integral before comparing convergent and formal matrix integrals. It then describes the loop equations and their solution in the one-matrix model. It also examines matrices coupled in a chain plus external field and concludes with a generalization of the topological recursion.
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Kaczynski, Bernice M., ed. The Oxford Handbook of Christian Monasticism. Oxford University Press, 2020. http://dx.doi.org/10.1093/oxfordhb/9780199689736.001.0001.
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The Handbook takes as its subject the complex phenomenon of Christian monasticism. It addresses, for the first time in one volume, the multiple strands of Christian monastic practice. Forty-four essays consider historical and thematic aspects of the Catholic, Eastern Orthodox, Oriental Orthodox, Protestant, and Anglican traditions, as well as contemporary ‘new monasticism’. The chapters in the book span a period of nearly two thousand years—from late ancient times, through the medieval and early modern eras, on to the present day. Taken together, they offer, not a narrative survey, but rather a map of the vast terrain. The intention of the Handbook is to provide a balance of some essential historical coverage with a representative sample of current thinking on monasticism. It presents the work of both academic and monastic authors, and the chapters are best understood as a series of loosely linked episodes, forming a long chain of enquiry, and allowing for various points of view. The authors are a diverse and international group, who bring a wide range of critical perspectives to bear on pertinent themes and issues. They indicate developing trends in their areas of specialization. The individual contributions, and the volume as a whole, set out an agenda for the future direction of monastic studies. In today’s world, where there is increasing interest in all world monasticisms, where scholars are adopting more capacious, global approaches to their investigations, and where monks and nuns are casting a fresh eye on their ancient traditions, this publication is especially timely.
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Macdougall, Iain C. Erythropoiesis-stimulating agents in chronic kidney disease. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0124.
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The advent of recombinant human erythropoietin (epoetin) in the late 1980s transformed the management of renal anaemia, liberating many dialysis patients from lifelong regular blood transfusions, in turn causing severe iron overload and human leucocyte antigen sensitization. Epoetin can be administered either intravenously or subcutaneously, but the half-life of the drug is fairly short at around 6–8 hours, necessitating frequent injections. To circumvent this problem, two manipulations to the erythropoietin molecule were engineered. The first of these was to attach an extra two carbohydrate chains to the therapeutic protein hormone (to make darbepoetin alfa), and the second was to attach a large pegylation chain to make continuous erythropoietin receptor activator. Both of these strategies prolonged the circulating half-life of the erythropoietin analogue. The next erythropoietic agent to be produced was peginesatide, a peptide-based agent which had no structural homology with native or recombinant erythropoietin, but shared the same biological and functional characteristics. Future strategies include stabilization of hypoxia-inducible factor, by orally active inhibitors of the prolyl hydroxylase enzyme, and advanced clinical trials are underway. In the meantime, several large randomized controlled trials have highlighted the potential harm in targeting a near normal haemoglobin of 13–14 g/dL (with an increased risk of cardiovascular complications), and sub-normal correction of anaemia is now advised. Some patients may show mild or severe resistance to erythropoiesis-stimulating agent (ESA) therapy, and common causes include iron insufficiency, infection, and underlying inflammation. Very rarely, patients may produce antibodies against their ESA, which neutralize not only the ESA, but also endogenous erythropoietin, causing pure red cell aplasia.
23
Smith, Rebecca. Smallpox. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0063.
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Symptoms of the smallpox virus include fever and a progressive papular rash that becomes vesicular and then pustular. A systemic inflammatory response syndrome (SIRS) leads to septic shock and death in 30% of cases. The definitive diagnosis can be confirmed via blood samples, lesion contents, or scrapings from crusts analyzed using electron microscopy, viral antigen immunohistochemistry, or polymerase chain reaction. The suspicion of a single smallpox case should lead to immediate notification of local public health authorities and the hospital epidemiologist. Because the disease does not exist in nature, smallpox should be considered the result of a bioterrorist attack until proven otherwise. An epidemiologic investigation is essential for determining the perimeter of the initial release so that tracking and quarantine of those exposed can be completed. Patients are extremely contagious and must be placed on contact, droplet, and airborne precautions in a negative pressure room.
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Taberlet, Pierre, Aurélie Bonin, Lucie Zinger, and Eric Coissac. DNA amplification and multiplexing. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198767220.003.0006.
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After a brief reminder of the principles underlying the polymerase chain reaction (PCR), Chapter 6 “DNA amplification and multiplexing” discusses the choice of a DNA polymerase for the PCR. In particular, it warns against the use of proofreading polymerases, that can lead to a substantial loss of PCR specificity. Chapter 6 insists on the benefits of including different types of controls in the PCR (e.g., PCR negatives and positives, tagging system controls, etc.). The most common causes of PCR failures and their solutions are addressed, as well as the precautions to take to avoid and monitor contaminations. Chapter 6 also deals with the particular case of blocking oligonucleotides, which aim at reducing the amplification of undesired sequences. It gives some valuable guidelines to design such oligonucleotides and use them efficiently. Finally, Chapter 6 presents different strategies for tagging individual samples during the amplification, to allow subsequent multiplexing during the sequencing step.
25
Civitello, Linda. The Federal Trade Commission Wars. University of Illinois Press, 2018. http://dx.doi.org/10.5406/illinois/9780252041082.003.0010.
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Baking powder companies repeatedly attempted to use federal agencies to limit competition. Calumet’s complaint against Royal to the FTC was inconclusive because both sides presented compelling scientific evidence. At the same time, baking powder companies began actively marketing to children, and Calumet created the famous slogan, “Double Acting.” The Hulmans renamed their product “Clabber Girl,” partly to capitalize on the popularity of the New American Woman, and withstood onslaughts from the Ku Klux Klan and new chain stores. At the end of the 1920s, the trade war ended abruptly when Royal and Calumet became subsumed in food conglomerates, Standard Brands and General Foods, respectively.
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Kendall-Tackett, Kathleen. Complementary and Alternative Treatments for Perinatal Depression. Edited by Amy Wenzel. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199778072.013.28.
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Complementary and alternative (CAM) treatments for depression are increasingly popular with new mothers seeking alternatives to antidepressants. This chapter reviews recent studies on the modalities that have the strongest empirical support. These include long-chain omega-3 fatty acids, S-adenosyl-L-methionine (SAMe), bright light therapy, exercise, and two herbal antidepressants (i.e., St. John’s wort, and kava). As our understanding of the anti-inflammatory mechanism underlying treatments for depression increases, this research may suggest still more treatments or combinations of treatments that can help pregnant and postpartum women recover quickly from perinatal depression. Safety considerations for breastfeeding mothers are reviewed for each modality, and reasons that mothers might choose these approaches over antidepressant medications are described.
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Russell, Tony. Rural Rhythm. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190091187.001.0001.
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Music historian Tony Russell explores a collection of records of early country music from the 1920s and ’30s, unlocking and revealing their hidden stories. The seventy-eight essays on selected 78rpm discs explain what they tell us about the musicians who sang and played the songs and tunes, the listeners who absorbed them, and the development of the genre—old-time music—in which they found a home. To illuminate their world, the author details how they were recorded, the intentions and interventions of the companies that made the recordings, and their fates once they were issued. There are songs, and stories of songs, about home and family, love and courtship, marriage and separation, childhood and schooldays, old age and death, crime and punishment, farms and floods, chain gangs and chain stores, wagons and automobiles, dogs and mules, drink, disasters, jokes, journeys, money, memories, and much more. Drawing on new research, contemporary newspapers, and previously unpublished interviews, Rural Rhythm charts the tempos and styles of rural and small-town music-making, and the gearshift that accelerated country music from the barndance pace of the 1920s to the hyperdrive of late-’30s proto-bluegrass and Western Swing: from “The Little Old Log Cabin in the Lane” to “New San Antonio Rose.” At the same time, it notates the larger rural rhythm of life in these years in the South, Southwest, and Midwest, with its recreations, its rituals, and its oddities, to produce a narrative that blends the musical and social history of the era.
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Reimers, David. The Impact of Immigration Legislation. Edited by Ronald H. Bayor. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199766031.013.002.
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Racism and economics account for the first laws directed at Chinese and Japanese. Entering as “picture brides,” Japanese women evaded the Gentlemen’s Agreement of 1907-1908 between the United States and Japan, but by use of the naturalization qualifications in the 1920s, Congress effectively closed the door to Asian immigration. For southern and eastern Europeans, national-origin quotas of the same decade cut their immigration drastically. After 1945, Congress and U.S. presidents relaxed the tight restrictions, and, in 1965, Congress passed the Hart-Celler Act, which created a new and more liberal system that stressed family unification. Major issues in recent years have concerned terrorism and undocumented immigration. Throughout this period, the results of the laws were often unintended, largely because the flow of immediate family members and chain migration were unseen.
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Newell, Heather, ed. Nested phase interpretation and the PIC. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198778264.003.0002.
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This chapter investigates phonological, morphological, and syntactic phenomena, aiming to demonstrate that the Phase Impenetrability Condition (Chomsky 2001) is epiphenomenal. The chapter therefore builds on the argumentation in Bošković (2007, 2014). It is demonstrated that the PIC cannot hold in the syntax, as the operations Merge (Late Adjunction), Move (post-spell-out movement), and Agree (long-distance Agree) can all be shown to cross phase boundaries. Morphological operations such as the anti-cyclic merger of morphemes (Late Adjunction) and spell-out of lower copies of a chain demonstrate the same permeability of the previously interpreted domains of phases. In the pure phonology, data displaying the effects of Phonological Merger (Newell and Piggott 2014) and Infixation demonstrate that phonological domains are not opaque for phonological operations, and that this transparency is not limited to phonological edges.
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Kastritis, Efstathios, and Meletios A. Dimopoulos. The patient with myeloma. Edited by Giuseppe Remuzzi. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0153_update_001.
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Renal impairment is a common feature of multiple myeloma and often the presenting symptom of a patient with symptomatic myeloma. ‘Myeloma kidney’ results from the excess of immunoglobulin light chains which form aggregates and casts that result in tubular obstruction; however, light chains may cause renal damage with a variety of mechanisms, which often may coexist in the same patient. The presence of significant renal dysfunction in a patient with myeloma is associated with a risk for significant complications, including early death. Myeloma kidney is usually associated with high tumour burden and high rates of paraprotein production.Patients with renal impairment should be managed immediately with appropriate antimyeloma therapy and supported vigorously. New drugs such as bortezomib are probably the most effective therapies for patients with renal dysfunction and may improve renal function in a significant proportion of patients with myeloma-related renal impairment, especially with dexamethasone at high doses. Other drugs such as thalidomide or lenalidomide may also be helpful in certain patients. Direct removal of the toxic free light chains may improve outcomes in some patients, but randomized studies are still ongoing. The role of plasmapheresis has not been established.Autologous stem cell transplantation, with appropriate dose adjustments for high-dose melphalan should be offered in eligible patients, even those on dialysis, although this procedure may be associated with a higher risk of toxicity in patients with more severe renal dysfunction. Renal transplantation may be an option for selected patients who have responded well to therapy.
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Speed, Cathy. Badminton injuries. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199533909.003.0054.
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The sport of badminton originated in Gloucestershire, England, in the 1860s and has evolved to become a game played by millions across the world. Badminton is the world’s fastest racket sport with shuttles reaching 200 mph in top international competitions. When played at high level, this fast and powerful game demands high levels of strength, agility, endurance, and tactical awareness. Most of the injuries seen are related to microtraumatic overuse, and are associated with high impact, lunging, rotating, and spinal extension. The mechanics of the sport present a good example of the influence of any impairment or dysfunction within the kinetic chain on other links along the same kinetic pathway. For example, restriction in the thoracic spine can lead to increased demands on the shoulder and arm when attempts are made to achieve adequate range of motion to play an overhead shot....
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Darwall, Stephen. Equal Dignity and Rights. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780199385997.003.0009.
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The contemporary notion of human dignity is taken to ground the idea of human rights. This chapter investigates how dignity must be understood if it is to be capable of doing that. Beginning with earlier conceptions of dignity, both hierarchical conceptions of status and the Ciceronian idea of human beings in the “great chain of being,” the chapter argues that to be capable of grounding rights, dignity must include a fundamental second-personal authority for human beings to make claims and demands of one another. More specifically, it contests the idea, advanced by Jeremy Waldron and Anthony Appiah, that human dignity is best theorized within a conception of honor and status as elevating all persons to the same high status. Any such honored status fails to ground the fundamental authority to hold one another accountable that is necessary for a conception of human dignity that is capable of grounding human rights.
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McKillen, Elizabeth. Making the World Safe for Workers? University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252037870.003.0007.
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This chapter examines the role of the American Federation of Labor (AFL) and Woodrow Wilson in the creation of the International Labor Organization (ILO) as an affiliate to the League of Nations at the Versailles Peace Conference in 1919. It begins with a discussion of the Bern conference in Switzerland and AFL President Samuel Gompers's travel to Paris to chair the Commission on International Labor Legislation that established ILO and framed a bill of labor rights for the Versailles Peace Treaty. The chapter then considers the conflict between Europe and the United States over the labor provisions of the peace treaty and the ILO, along with the opposition coming from labor groups and left-leaning diaspora political coalitions. It also analyzes Gompers's campaign in defense of the entire Versailles “package,” including his proposed labor conventions involving the AFL, the Pan American Federation of Labor, and the International Federation of Trade Unions. Finally, it describes Wilson's support for ILO and its labor provisions as part of his efforts to incorporate respectable labor into international governance.
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Vuorinen, Ilppo. Post-Glacial Baltic Sea Ecosystems. Oxford University Press, 2018. http://dx.doi.org/10.1093/acrefore/9780190228620.013.675.
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Post-glacial aquatic ecosystems in Eurasia and North America, such as the Baltic Sea, evolved in the freshwater, brackish, and marine environments that fringed the melting glaciers. Warming of the climate initiated sea level and land rise and subsequent changes in aquatic ecosystems. Seminal ideas on ancient developing ecosystems were based on findings in Swedish large lakes of species that had arrived there from adjacent glacial freshwater or marine environments and established populations which have survived up to the present day. An ecosystem of the first freshwater stage, the Baltic Ice Lake initially consisted of ice-associated biota. Subsequent aquatic environments, the Yoldia Sea, the Ancylus Lake, the Litorina Sea, and the Mya Sea, are all named after mollusc trace fossils. These often convey information on the geologic period in question and indicate some physical and chemical characteristics of their environment. The ecosystems of various Baltic Sea stages are regulated primarily by temperature and freshwater runoff (which affects directly and indirectly both salinity and nutrient concentrations). Key ecological environmental factors, such as temperature, salinity, and nutrient levels, not only change seasonally but are also subject to long-term changes (due to astronomical factors) and shorter disturbances, for example, a warm period that essentially formed the Yoldia Sea, and more recently the “Little Ice Age” (which terminated the Viking settlement in Iceland).There is no direct way to study the post-Holocene Baltic Sea stages, but findings in geological samples of ecological keystone species (which may form a physical environment for other species to dwell in and/or largely determine the function of an ecosystem) can indicate ancient large-scale ecosystem features and changes. Such changes have included, for example, development of an initially turbid glacial meltwater to clearer water with increasing primary production (enhanced also by warmer temperatures), eventually leading to self-shading and other consequences of anthropogenic eutrophication (nutrient-rich conditions). Furthermore, the development in the last century from oligotrophic (nutrient-poor) to eutrophic conditions also included shifts between the grazing chain (which include large predators, e.g., piscivorous fish, mammals, and birds at the top of the food chain) and the microbial loop (filtering top predators such as jellyfish). Another large-scale change has been a succession from low (freshwater glacier lake) biodiversity to increased (brackish and marine) biodiversity. The present-day Baltic Sea ecosystem is a direct descendant of the more marine Litorina Sea, which marks the beginning of the transition from a primeval ecosystem to one regulated by humans. The recent Baltic Sea is characterized by high concentrations of pollutants and nutrients, a shift from perennial to annual macrophytes (and more rapid nutrient cycling), and an increasing rate of invasion by non-native species. Thus, an increasing pace of anthropogenic ecological change has been a prominent trend in the Baltic Sea ecosystem since the Ancylus Lake.Future development is in the first place dependent on regional factors, such as salinity, which is regulated by sea and land level changes and the climate, and runoff, which controls both salinity and the leaching of nutrients to the sea. However, uncertainties abound, for example the future development of the Gulf Stream and its associated westerly winds, which support the sub-boreal ecosystems, both terrestrial and aquatic, in the Baltic Sea area. Thus, extensive sophisticated, cross-disciplinary modeling is needed to foresee whether the Baltic Sea will develop toward a freshwater or marine ecosystem, set in a sub-boreal, boreal, or arctic climate.
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Barclay, Philip, and Helen Scholefield. High dependency and intensive care. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198713333.003.0030.
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The development of maternal critical care is essential in reducing morbidity and mortality due to a substandard level of care. The level of critical care should depend upon the patient’s severity of illness, not their physical location. Escalation to level 3 (intensive) care is uncommon in pregnancy, with a median admission rate of 2.7 per 1000 births, mainly due to hypertensive disorders of pregnancy and haemorrhage. Maternal ‘near misses’ occur more frequently, with 6.5 per 1000 births meeting Mantel’s criteria, of which 85% is due to major obstetric haemorrhage. The admission rate to maternal high dependency units (level 2 care) varies from 1% to 5%. Acute physiological scoring systems have been found to be reliable when applied to parturients receiving level 3 care but overestimate mortality. Maternal early warning scores have been derived from simplified versions of these systems, with allowance made for physiological changes seen in pregnancy. There are many different maternity scoring systems in use throughout England and Wales. All share the same principle that parameters should be recorded regularly during the hospital stay, with deviations from normal quantified, recorded, and acted upon. A chain of response is then required to ensure that suitably qualified staff, possessing appropriate critical care competencies, attend in a timely fashion. Appropriate resources must be available with equipment readily to hand and suitably trained staff so that invasive monitoring can be used. Clear admission criteria are required for level 2 care within the delivery suite and escalation to level 3, with suitable arrangements for transfer.
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Stahle, David W., Dorian J. Burnette, Daniel Griffin, and Edward R. Cook. Thirteenth Century AD. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780199329199.003.0009.
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The hypothesis that a prolonged drought across southwestern North America in the late thirteenth century contributed to the abandonment of the region by Ancestral Pueblo populations, ultimately including the depopulation of the Mesa Verde region, continues to be a focus of archaeological research in the Pueblo region. We address the hypothesis through the re-measurement of tree-ring specimens from living trees and archaeological wood at Mesa Verde, Colorado, to derive chronologies of earlywood, latewood, and total ring width. The three chronology types all date from AD 480 to 2008 and were used to separately reconstruct cool and early warm season effective moisture and total water-year precipitation for Chapin Mesa near many of the major prehistoric archaeological sites. The new reconstructions indicate three simultaneous cool and early growing season droughts during the twelfth and thirteenth centuries that may have contributed to the environmental and social factors behind Ancestral Pueblo migrations over this sector of the Colorado Plateau. These sustained inter-seasonal droughts included the “Great Drought” of the late-thirteenth century, which is estimated to have been one of the most severe regimes of cool and early summer drought in the last 1,500-years and coincided with the end of Puebloan occupations at Mesa Verde. The elevation of the 30 cm isohyet of water-year precipitation reconstructed for southwestern Colorado from the new ring-width data is mapped from AD 1276–1280 and identifies areas where dry-land cultivation of maize may not have been practical during the driest years of the Great Drought. There is no doubt about the exact dating of the tree-ring chronologies, but the low sample size of dated specimens from Mesa Verde during the late-thirteenth and fourteenth centuries contributes uncertainty to these environmental reconstructions at the time of abandonment.
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Chankseliani, Maia. What Happened to the Soviet University? Oxford University PressOxford, 2022. http://dx.doi.org/10.1093/oso/9780192849847.001.0001.
Full textAbstract:
Abstract This monograph explores how one of the largest geopolitical changes of the twentieth century—the dissolution of the Soviet Union—triggered and inspired the reconfiguration of the Soviet university. The reader is invited to engage in a historical and sociological sensemaking of radical and incremental changes affecting 69 former Soviet universities since the early 1990s. The monograph departs from traditional deficit-oriented, internalist explanations of change and illustrates how global flows of ideas, people, and finances have impacted higher education transformations in this region. It also identifies areas of persistence. The processes of marketisation, internationalisation, and academic liberation are analysed to show that universities have maintained certain traditions while adopting and internalising new ways of fulfilling their education and research functions. Soviet universities have survived chaotic processes of post-Soviet transformations and have self-stabilised with time. Most of them remain flagship institutions with large numbers of students and relatively high research productivity. At the same time, the majority of these universities operate in a top-down, one-man management environment with limited institutional autonomy and academic freedom. As the homes of intellectuals, universities represent a duality of opportunity and threat. Universities can nurture collective possibilities, imagining and bringing about a different future. At the same time, or perhaps because of this, the probability is high that universities will continue to be perceived as threats to governments with authoritarian inclinations. One message to take away from this monograph is that the time is ripe for former Soviet universities to loosen their last remaining chains.
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Rensmann, Thilo, ed. Small and Medium-Sized Enterprises in International Economic Law. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780198795650.001.0001.
Full textAbstract:
While international trade and investment is still dominated by larger multinational enterprises (MNEs), small and medium-sized enterprises (SMEs) are increasingly reaching out beyond their traditional domestic habitat. A significant number of SMEs today are engaged in transboundary trade and investment and in the wake of the digital revolution the phenomenon of ‘born global’ SMEs can be increasingly observed. In addition, many SMEs enter the global economy indirectly via global value chains. International economic law, with its traditional focus on MNEs and their interests, is only slowly waking up to this new reality. At the same time, it is increasingly recognized that the internationalization of SMEs provides the key to creating more sustainable and inclusive global economic growth. The 2015 UN Sustainable Development Goals, for example, expressly call for the facilitation of increased access for SMEs to international trade and investment. This book undertakes a first attempt at systematically analysing the interaction between SMEs and international economic law. The analysis covers a broad spectrum of international trade and investment law focusing on issues of particular interest to SMEs, such as trade in services, government procurement, and trade facilitation. Salient regional and transregional developments are taken into account, including the implications of the TPP and the TTIP negotiations for SMEs. Close attention is also devoted to the concern of many states that further liberalization of international trade and investment would unduly restrict the regulatory space necessary to protect and promote the legitimate interests of domestic SMEs.
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Wills, David. Killing Times. Fordham University Press, 2019. http://dx.doi.org/10.5422/fordham/9780823283521.001.0001.
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Killing Times starts from the deceptively simple observation— made by Jacques Derrida—that the death penalty mechanically interrupts mortal time, preempting our normal experience of not knowing when we will die. The book examines more broadly what constitutes mortal temporality and how the “machinery of death” exploits and perverts time. It first examines Eighth Amendment challenges to the death penalty in the U.S, from the late nineteenth-century introduction of execution by firing squad and the electric chair to current cases involving lethal injection. Although defining the instant of death emerges as an insoluble problem, all the machines of execution of the post-Enlightenment period presume to appropriate and control that instant, ostensibly in service of a humane death penalty. That comes into particular focus with the guillotine, introduced in France in 1791–92, at the same moment as the American Bill of Rights. Later chapters analyze how the instant of the death penalty works in conjunction with forms of suspension, or extension of time and how its seeming correlation between egregious crime and painless execution is complicated in various ways. The book’s emphasis on time then allows it to expand the sense of the death penalty into suicide bombing, where the terrorist seeks to bypass judicial process with a simultaneous crime and “punishment”; into targeted killing by drone, where the time-space coordinates of “justice” are compressed and disappear into the black hole of secrecy; and into narrative and fictive spaces of crime, court proceedings, and punishment.
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Jancura, Daniel, and Erik Sedlák. Bioenergetika. Univerzita Pavla Jozefa Šafárika, Vydavateľstvo ŠafárikPress, 2021. http://dx.doi.org/10.33542/be2021-0022-6.
Full textAbstract:
Prekladaný vysokoškolský učebný text „Bioenergetika“ by mal slúžiť ako úvod do problematiky štúdia v oblasti bioenergetiky. Táto vedná oblast je v súčasnosti vysoko aktuálna, pretože výsledky získané bioenergetickým výskumom v uplynulých rokoch zreteľne ukazujú, že bioenergetické procesy prebiehajúce v živých systémoch neslúžia “len” na transformáciu energie, ale ovplyvňujú aj priebeh procesov ako sú apoptóza, starnutie, vznik a rozvoj mnohých ochorení (predovšetkým neurodegeneratívnych). Tieto skutočnosti jednoznačne naznačujú potrebu existencie kvalitných učebných textov, ktoré by prijateľným spôsobom umožnili študentom získať potrebné informácie a vedomosti v tejto vednej discipline. Z vyššie uvedených dôvodov sme sa rozhodli vytvoriť tieto učebné texty, ktoré sú vo forme desiatich samostatných kapitol, ktoré však na seba prirodzene a logicky nadväzujú. Jedna kapitola predstavuje v podstate jednu prednášku v rámci kurzu Bioenergetiky, ktorý je realizovaný na Prírodovedeckej fakulte Univerzity Pavla Jozefa Šafárika v Košiciach na magisterskom a doktorandskom stupni študijného programu „Biofyzika“. Zároveň tieto texty môžu poslúžiť aj pri výučbe v študijnom predmete Biochémia, ktorý je prednášaný v bakalárskych a magisterských stupňoch študijných programov “Biochémia” resp. “Biofyzika”. Dovoľujeme si vyjadriť presvedčenie, že tieto učebné texty by mohli byť istým spôsobom nápomocné aj vedeckým pracovníkom pracujúcim v oblasti výskumu týkajúcho sa problematiky transformáci energie v biologických organizmoch a fenoménoch spojených s touto transformáciou. V týchto učebných textoch sú postupne uvádzané poznatky týkajúce sa základných konceptov bioenergetiky, mechanizmov procesov ako sú glykolýza a Krebsov cyklus (okrem podrobného a uceleného popis týchto procesov je tu uvedený aj všeobecný náhľad o prepojenosti týchto procesov ako aj ich začlenenie do kompaktného pohľadu na celkový proces transformácie energie v biologických organizmoch), zloženia štruktúry a funkčnosti biologických membrán (táto oblast je nevyhnutná pre lepšie pochopenie poznatkov, ktoré sú uvedené v nasledujúcich kapitolách). V nasledujúcich kapitolách sa učebný text zaoberá popisom štruktúry a funkcie mitochondrií, pričom veľký dôraz je dávaný na popis vlastností a mechanizmov fungovania štyroch komplexov dýchacieho reťazca a ATP-syntázy. Tieto komplexy vytvárajú podmienky pre existenciu “najdôležitejšieho” bioenergetického procesu, oxidatívnej fosforylácie. V záverečných dvoch kapitolách sú uvedené mechanizmy procesov vytvárajúcich fotosyntézu, jej svetlej aj tmavej fázy. Sú tu relevantné informácie o tomto “druhom” najdôležitejšom bioenergetickom procese prebiehajúcom v mnohých biologických organizmoch a poskytujúcom možnosť transformácie enrgie elektromagnetického žiarenia na energiu “ukrytú” v chemických väzbách určitých chemických molekúl. Chceme vyjadriť naše presvedčenie, že predložené učebné texty “Bioenergetika” budú dobrým “pomocníkom a inšpirátorom” pre mnohých študentov, ktorí sa budú chcieť dozvedieť čo najviac o fascinujúcich štruktúrach a mechanizmoch umožňujúcich transformáciu energie v živých systémoch, bez ktorej by nebola možná existencia života ako ho poznáme. Želáme príjemné a podnetné čítanie a štúdium. URL: www.unibook.upjs.sk The textbook "Bioenergetics" should serve as an introduction to the study of bioenergetics. This field of science is currently highly actual, as the results of the bioenergetics research in recent years clearly show that bioenergetics processes in living systems can "serve" not only to transformation of energy, but also affect the course of processes such as apoptosis, aging, origin and development of many diseases (especially neurodegenerative). These facts clearly indicate the need for the existence of quality teaching texts that would allow students to acquire the necessary information and knowledge in this scientific discipline in an acceptable way. For the above mentioned reasons, we decided to create these textbooks, which are in the form of ten chapters, which naturally and logically follow each other. One chapter basically presents one lecture within the course of Bioenergetics, which is realized at the Faculty of Science of the Pavel Jozef Šafárik University in Košice at the master's and doctoral degree of the study program "Biophysics". At the same time, these texts can also be used for teaching in the study subject Biochemistry, which is taught in the bachelor's and master's degree programs of the study programs "Biochemistry" resp. “Biophysics”. We would like to express our conviction that these textbooks could in some way also help researchers working in the field of the energy transformation in biological organisms and the phenomena associated with this transformation. These textbooks present knowledge about the basic concepts of bioenergetics, the mechanisms of processes such as glycolysis and the Krebs cycle (in addition to a detailed and comprehensive description of these processes, there is also a general view of the interconnectedness of these processes and their incorporation into a compact view of the overall energy transformation in biological organisms), the structure and functionality of biological membranes (this area is necessary for a better understanding of the knowledge presented in the following chapters). In the following chapters, the textbook deals with the description of the structure and function of mitochondria, with great emphasis on the properties and mechanisms of functioning of the four complexes of the respiratory chain and ATP-synthase. These complexes create the basis for the existence of the "most important" process in bioenergetics, oxidative phosphorylation. In the final two chapters, the mechanisms of the processes that produce photosynthesis, its light and dark phases, are presented. There is relevant information about this "second" most important bioenergetics process taking place in many biological organisms and providing the possibility of transforming the energy of electromagnetic radiation into energy "hidden" in the chemical bonds of certain chemical molecules. We want to express our conviction that the textbooks "Bioenergetics" will be a good "helper and inspirer" for many students who want to learn as much as possible about the fascinating structures and mechanisms for energy transformation in living systems, without which it would not be possible existence of life as we know it.