Relevant bibliographies by topics / Saliva

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  2. Dissertations / Theses
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  5. Conference papers
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Academic literature on the topic 'Saliva'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 July 2024

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Journal articles on the topic "Saliva"

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Yanet, Medina Rojas, Vargas Campos Luis Eder, Vargas Campos Adriana, Rivera Ramírez Ana Bertha, Gallardo Montoya Juan Manuel, Luna Gomez Juan Manuel, Adams Ocampo Julio Cesa, and Vargas Zuñiga Luis Martin. "Comparación de las concentraciones de glucosa plasmática y saliva en sujetos sanos." Archives of Health 2, no. 5 (July 28, 2021): 1429–40. http://dx.doi.org/10.46919/archv2n5-005.

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RESUMEN INTRODUCCIÓN: La saliva pueda ser utilizada como un líquido de diagnóstico para evaluar el estado de salud. OBJETIVO: Comparar la glucosa salival con la glucemia plasmática en sujetos sanos. MATERIAL / MÉTODOS: Se analizaron saliva no estimulada de 99 mujeres y 47 hombres aparentemente sanos. RESULTADOS: Al comparar la glucosa plasmática vs. la saliva en mujeres encontramos que hay una fuerte diferencia estadística 68.723 ± 7.302 mg/dL plasmática vs 24.44 ± 2.095 mg/dL salival (p= 0.0001), de manera similar ocurrió en los hombres 70.393 ± 9.00 mg/dL plasmática vs 24.93 ± 2.643 salival (p ≤ 0.0001). CONCLUSION: Que la concentración de glucosa en la saliva pudiera ser un buen método para evaluar de manera no invasiva la concentración de glucosa en el organismo. ABSTRACT INTRODUCTION: Saliva can be used as a diagnostic fluid to assess health status. OBJECTIVE: To compare salivary glucose with plasma glucose in healthy subjects. MATERIAL/METHODS: Unstimulated saliva from 99 apparently healthy women and 47 apparently healthy men was analyzed. RESULTS: Comparing plasma glucose vs saliva in women we found that there is a strong statistical difference 68.723 ± 7.302 mg/dL plasma vs 24.44 ± 2.095 mg/dL saliva (p= 0.0001), similarly it occurred in men 70.393 ± 9.00 mg/dL plasma vs 24.93 ± 2.643 saliva (p ≤ 0.0001). CONCLUSION: That glucose concentration in saliva could be a good method to evaluate in a non-invasive way the glucose concentration in the organism.
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Azevedo, Carolini Contreiro, Manoelito Ferreira Silva Júnior, Antônio Augusto Gomes, Ana Paula Martins Gomes, and Ana Maria Martins Gomes. "Avaliação do fluxo, pH e capacidade tampão da saliva no período gestacional e pós-parto: um estudo caso-controle prospectivo." Revista Brasileira de Pesquisa em Saúde/Brazilian Journal of Health Research 24, no. 1 (December 7, 2022): 103–13. http://dx.doi.org/10.47456/rbps.v24i1.23034.

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Introdução: Ainda há divergência na literatura sobre as alterações salivares durante o período gestacional. Objetivo: Avaliar o fluxo, o pH e a capacidade tampão da saliva de mulheres no período gestacional e pós-parto e comparar com mulheres não gestantes. Métodos: O estudo caso-controle prospectivo foi realizado com amostra de conveniência entre gestantes (G) e não gestantes (NG) (1 caso: 2 controles). A coleta de saliva estimulada foi realizada pela manhã durante a gestação (20ª, 30ª e 38ª semanas de gestação) e pós-parto. Os dados obtidos foram analisados pelos testes de Shapiro-Wilk, t-Student, Mann-Whitney e Friedman (p<0,05). Resultados: Houve participação de 17 mulheres gestantes, com média de idade de 26,1 ± 4,4 anos; e 28 não gestantes, com média de 24,1 ± 4,5 anos. Houve diferença no fluxo salivar (p=0,023) e na capacidade tampão (p=0,033) entre G e NG no período de pós-parto, como também no pH da saliva nas 20ª (p=0,007) e 30ª semanas (p=0,010) de gestação. No grupo das gestantes, o fluxo e pH da saliva não apresentou alteração ao longo da gestação e no pós-parto (p>0,05). No entanto, a capacidade tampão da saliva aumentou no pós-parto (p<0,001). Conclusão: O fluxo salivar e capacidade tampão das gestantes foram menores no pós-parto, e o pH da saliva foi menor no período gestacional (20ª e 30ª semanas), quando comparado com o grupo de mulheres não gestantes. Entre as gestantes, não houve mudança no fluxo salivar e pH da saliva, mas houve aumento da capacidade tampão da saliva no tempo de acompanhamento.
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Vesthi, Nifarea Anlila, Grahita Aditya, and Rizki Amalina. "HUBUNGAN KADAR UREA SALIVA TERHADAP DERAJAT KEASAMAN (pH) SALIVA PADA ANAK USIA 12-15 TAHUN." ODONTO : Dental Journal 2, no. 1 (December 1, 2015): 57. http://dx.doi.org/10.30659/odj.2.2.57-61.

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Introduction: One of the dental disease in the oral cavity that often experience by society are caries. Caries is one of the hard tooth tissue disease that can touch enamel, dentin, and sementum. One of the factor that affect caries process is saliva. Urea is one of the organic composition that compose saliva. Urea in salive plays as buffer capacity and the pH saliva adjustment.Methods: This study is an analytic observational with cross sectional approach, this study are conducted in Daarul 'Ilmi Islamic boarding school with 19 subject of 12-15 years old child. The data are obtained from the examination of urea saliva level and pH saliva in child. The level of urea saliva are measured using spectrophotometer tools and the pH saliva are measured using pH meter. The Shapiro-wilkare used to deterime the data normality, continue with Leuvenetest to determinde the data homogeneity data. Data are analyzed using Pearson test to determine the relation of urea level in saliva against the pH saliva.Results: According the data analysis, the data are in normal distribution and homogeneous. The research result are obtain average of urea level in urea sample is 13,45 mg/dl, and the average of pH saliva sampelis 7,15. The result of Pearsonstatistic testare obtain p value of = 0,000, with the positive correlation level of 0,902.Conclusion: The conclusion of this study are note that there are relation between the urea level in saliva against pH salive. This are proven from the Pearson test result with significance value of 0.000 (p< 0.05).
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Jordão, Maisa C., Franciny Q. Ionta, Bianca T. P. Bergantin, Gabriela C. Oliveira, Marcelo J. Moretto, Heitor M. Honório, Thiago C. Silva, and Daniela Rios. "The Effect of Mucin in Artificial Saliva on Erosive Rehardening and Demineralization." Caries Research 51, no. 2 (2017): 136–40. http://dx.doi.org/10.1159/000454817.

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The effect of mucin in artificial saliva on rehardening (RE-experiment) and inhibition (DE-experiment) of erosion was evaluated. The treatment groups were: artificial saliva with mucin, artificial saliva without mucin, human saliva, and water. For the RE-experiment, after immersion of enamel blocks in citric acid (4 min), hardness was measured and blocks were subjected to treatment for 2 h. For the DE-experiment, sound blocks were subjected to treatment for 2 h and immersed in citric acid (4 min). Percentages of hardness recovery (RE) and loss (DE) were analyzed (ANOVA/Tukey's test). The salivas promoted similar rehardening, but only the saliva with mucin was similar to human saliva with regard to enamel protection against erosion.
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Marković, Srđan, Adrijana Serafimovka, Ivana Kostić, Marija Jovović, Maja Ribar, Branko Bugarski, and Dragana Kastratović. "Salviva®: Step forward in human saliva substitution." Hospital Pharmacology - International Multidisciplinary Journal 7, no. 3 (2020): 976–82. http://dx.doi.org/10.5937/hpimj2003976m.

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Introduction: Saliva is a product of salivary glands secretion that constantly soaks-moisturizes the teeth and mucous membranes of the oral cavity. Physiological roles of saliva are: maintaining humidity, lubrication and physiological cleaning of the oral cavity, enzymatic activity (beginning of digestion), bacteriostatic and bactericidal action, prevention of dental caries. Topic: The most serious health problem is the complete, permanent absence of saliva secretion , which is an absolute indication for daily use of an adequate preparation for moistening the oral cavity or saliva substitution. Salviva ® is sufficiently viscous and the content that can serve as natural saliva for 4 hours. 200 ml bottle is sufficient for daily patient needs and the production costs are low (0.25 EUR per unit for laboratory level volumes, excluding primary packaging costs). Conclusions: With the further innovative development of Salviva ® , it is possible to apply drugs with local and systemic effects, and thus treat the patient, which opens a completely new field of application of some drugs and reduces their side effects and unpleasant effects. The quality of life of patients as well as social functionality will be significantly improved, which is very important for the working population.
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Mikaele Garcia de Medeiros, Maria Cecília Azevedo De Aguiar, Maurício Duarte da Conceição, Osman Sandonaithy Leite de Souza, Eduardo José Guerra Seabra, and Juliana Carvalho Sá. "Análise salivar por meio de diferentes técnicas de sialometria utilizadas em adultos jovens saudáveis." RSBO 19, no. 2 (November 7, 2022): 352–08. http://dx.doi.org/10.21726/rsbo.v19i2.1876.

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A saliva é uma secreção com funções importantes relacionadas à manutenção da integridade bucal e sistêmica, como atividade antimicrobiana, autolimpeza, lubrificação, manutenção do pH do trato digestivo superior e auxílio em ações como mastigação, deglutição, fonação, entre outras. Objetivo: Avaliar três diferentes técnicas de sialometria com relação à quantidade de saliva produzida, facilidade de aferição e execução, além da análise da coloração, viscosidade e turbidez da saliva coletada. Material e métodos: 74 alunos de Odontologia passaram por três testes de sialometria (sem estímulo, por estímulo mecânico e por estímulo gustatório), em que foram avaliadas a quantidade e qualidade salivar. Resultados: O maior fluxo salivar médio foi produzido pelo estímulo gustatório (3,44 ml por minuto), seguido do estímulo mecânico (1,46 ml por minuto) e do fluxo sem estímulo (0,3 ml por minuto). A viscosidade da saliva coletada sem estímulo obteve valores, em média, maiores (5,0 cm) do que daquela por estímulo mecânico (1,6 cm). Uma maior turbidez foi encontrada após a estimulação mecânica. Conclusão: Os métodos sialométricos testados foram de fácil aferição e execução. A estimulação mecânica e gustatória foram eficazes para o aumento do volume de saliva, sendo o estímulo gustatório capaz de produzir maior quantidade salivar. Espera-se que profissionais da área da saúde possam lançar mão desse importante meio de diagnóstico, simples e de baixo custo, possibilitando empregá-lo como rotina na prática diária clínica.
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Archibald, David W., Carla A. Hebert, Kevin L. Gregory, and George K. Lewis. "Effects of Human Salivas on Recombinant HIV-1 Proteins." Critical Reviews in Oral Biology & Medicine 4, no. 3 (April 1993): 475–78. http://dx.doi.org/10.1177/10454411930040033101.

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Human saliva appears to contain factors that are inhibitory to HIV-1 infectivity in vitro. We investigated the effect of incubating human whole, parotid, labial minor salivary gland and sublingual/submandibular salivas with recombinant HIV-1 envelope protein (gpl60). Saliva/gpl60 mixtures were run on polyacrylamide gels, transferred to nitrocellulose, and assayed for the presence of gp 160 using monoclonal antibodies or HIV-1-positive sera. Incubation of the gp 160 with whole saliva reduced the intensity of gp 160 bands to 35% of control values. Minor salivary gland saliva reduced the band intensities to 65% of control values, while other saliva types diminished gp160 to 75% of control values. Protease inhibitors had no effect. Components of untreated whole human saliva prevent the detection of the HIV-1 envelope protein gp 160 by antibodies to gp120 and gp41 in immunoblots. The results suggest that complexes between whole saliva factors and certain domains of gp160 block monoclonal antibody binding or are unable to migrate through polyacrylamide gels.
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Tiziani, Angela. "Técnica de medição de saliva utilizada no CECOM em pacientes com halitose." Sínteses: Revista Eletrônica do SIMTEC, no. 6 (October 27, 2016): 177. http://dx.doi.org/10.20396/sinteses.v0i6.8813.

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A saliva é um fluido aquoso e transparente secretado pelas glândulas salivares diretamente na cavidade bucal. É composta, principalmente, de água (99%) e componentes orgânicos e minerais. Uma de suas principais funções é a autolimpeza da boca. Quando há diminuição do fluxo salivar, observa-se maior estagnação de matéria orgânica sobre a língua, como células epiteliais descamadas e bactérias, formando a Saburra Lingual. A degradação da Saburra Lingual pelas bactérias provoca a formação de compostos sulfurados voláteis que causam o mau hálito. Uma boa quantidade de saliva é um dos fatores importantes para manter o hálito agradável. Neste trabalho, vamos demonstrar a técnica de medição de saliva que utilizamos no Cecom para tratamento da Halitose. Para esta técnica, utilizamos um tubo de Proveta com medições, um tubete de silicone de 1,5 cm de comprimento e um cronômetro. O paciente deve mastigar o tubete de silicone, durante 5 minutos, e ir cuspindo toda a saliva que for sendo produzida para dentro do tubo de Proveta. Ao final dos cinco minutos, medimos a quantidade de saliva dentro do tubo e dividimos este valor por 5. Desta maneira, obtemos o fluxo salivar do paciente. Com a saliva dentro do tubo de Proveta, avaliamos os padrões salivares do paciente, como quantidade, coloração, turbidez e viscosidade. Se for encontrada alguma alteração, realizamos o tratamento adequado para reestabelecer os padrões normais, através de Sialogogos, que estimulam a produção da saliva de diversas maneiras.
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Delgado Montoya, Gisele, Myriam Flores Valderrama, and Diana Lucía Díaz Montoya. "Relación de la concentración del ion tiocianato salival y el recuento de bacterias aerobias en saliva en personas fumadoras y no fumadoras." Ciencia y Desarrollo 18, no. 1 (August 5, 2016): 7. http://dx.doi.org/10.21503/cyd.v18i1.1083.

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El ion tiocianato es una sustancia derivada del cianuro, el cual es metabolizado en nuestro organismo, para luego liberarse en diversos fluidos organicos, tales como la saliva, donde es transformado a ion hipotiocianato mediante el sistema lactoperoxidasa, atribuyendosele una funcion antibacteriana. El objetivo fue relacionar la concentracion del ion tiocianato salival y el recuento de unidades formadoras de colonias (UFC) de bacterias aerobias en la saliva. La concentracion del ion tiocianato salival se cuantifico por espectrofotometria, luego de someter las muestras a la reaccion de Koning. El recuento de las UFC se realizo despues de cultivar las muestras de saliva en Agar Cuenta Colonias. La relacion de ambas variables se evaluaron mediante regresion lineal y los resultados entre los distintos grupos de personas se compararon mediante la prueba de significancia de Tukey. Las personas que fumaban diariamente tuvieron concentraciones significativamente mayores (2,27 x 10-3M) que los fumadores interdiarios (1,62 x10-3M), los fumadores sociales (1,40 x 10-3M) y los no fumadores (1,33 x 10-3 M). Para el numero de UFC totales hubo diferencia significativa entre los fumadores habituales (476x103 UFC/ml de saliva) respecto a los demas grupos, 798x103 UFC/ml en los que fumaban interdiario, 1012x103 UFC/ml en los fumadores sociales y 1101x103 UFC/ml en las personas no fumadoras.Al relacionarse ambas variables, se observo una muy buena fuerza de correlacion (r=-0,845) para las bacterias aerobias totales y para estreptococos(r=-0,718) con la concentracion de tiocianato. Por lo tanto, a mayor concentracion del ion tiocianato salival, disminuira el numero de UFC de aerobios totales y por supuesto el numero de estreptococos en la saliva. No existe relacion entre la concentracion de tiocianato salival y la cantidad de estafilococos salivales, como lo indica el coeficiente de correlacion (r=0,415). Palabras clave: bacterias de la saliva, ion hipotiocianato, ion tiocianato, fumadores.DOI: http://dx.doi.org/10.21503/CienciayDesarrollo.2015.v18i1.01
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Eckley, Claudia Alessandra, and Henrique Olival Costa. "Estudo comparativo do pH e do volume salivar em indivíduos com laringofaringite crônica por doença do refluxo gastroesofágica antes e após o tratamento." Revista Brasileira de Otorrinolaringologia 72, no. 1 (February 2006): 55–60. http://dx.doi.org/10.1590/s0034-72992006000100010.

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INTRODUÇÃO: A Doença do Refluxo Gastroesofágico (DRGE) é a doença digestiva mais prevalente da atualidade e, recentemente, tem sido implicada em uma gama de alterações do seguimento laringofaríngeo (RLF). No entanto, pouco se sabe dos mecanismos fisiopatológicos destas manifestações supraesofágicas da DRGE. Os achados clínicos contraditórios e recentes pesquisas sugerem haver deficiências na capacidade de defesa deste seguimento. Uma das principais responsáveis pela homeostase da mucosa oral e do trato digestivo é a saliva com seu conteúdo orgânico e inorgânico. Tanto alterações do pH quanto do volume salivar já foram correlacionados com os sintomas e sinais sugestivos da DRGE e RLF. Estudo recente de nossa autoria demonstra diminuição estatisticamente significante do pH salivar de indivíduos com RLF quando comparado a controles sem a doença. Outro estudo constatou correlação entre a redução do volume X pH da saliva em indivíduos com DRGE, estando esta redução diretamente relacionada aos níveis de pH esofágico constatados durante pH-metria esofágica de 24 horas. OBJETIVOS: Avaliar como se comportam o pH e volume da saliva em um mesmo indivíduo com DRGE e RLF antes e após o tratamento clínico. MATERIAL E MÉTODO: Vinte e três pacientes com RLF tiveram o pH e volume da saliva total testados antes e após receberem tratamento com droga bloqueadora de bomba de prótons durante 12 semanas. RESULTADOS: Houve uma diferença estatisticamente significante (p<0,001) entre o pH da saliva antes e após o tratamento, estando este maior após o controle clínico da doença. O volume de saliva no paciente tratado foi significativamente maior do que no paciente pré-tratamento (p=0.009). DISCUSSÃO: Os achados sugerem que o pH salivar é influenciado pela presença de refluxo gastroduodenal à região laringofaríngea. Caso estudos futuros com populações maiores realmente comprovem esta correlação, poderemos cogitar a possibilidade de usar a mensuração do pH salivar, que é feita de forma rápida e não invasiva, como um meio de diagnosticar e avaliar o comportamento e controle do Refluxo Laringofaríngeo.
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Dissertations / Theses on the topic "Saliva"

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Москаленко, Павло Олександрович, Павел Александрович Москаленко, Pavlo Oleksandrovych Moskalenko, Юрій Володимирович Лахтін, Юрий Владимирович Лахтин, Yurii Volodymyrovych Lakhtin, A. A. Levkov, Юрій Владиславович Сміянов, Юрий Владиславович Смиянов, and Yurii Vladyslavovych Smiianov. "Application of saliva crystalloscopy methods in the diagnosis of malignant tumours of salivary glands and Sjögren disease." Thesis, Published by IASHE London, 2015. http://essuir.sumdu.edu.ua/handle/123456789/44378.

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A high informational content of saliva crystalloscopy in the diagnosis of salivary glands tumours was proven; typical symptoms of Sjögren disease and malignant tumours of the salivary glands were found on the ground of the analysis of the presented research method.
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Couto, Josà Luciano Pimenta. "Estudo de parÃmetros salivares em portadores de picnodisostose." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=6090.

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A picnodisostose à uma displasia esquelÃtica caracterizada por baixa estatura, osteoclerose, acrosteÃlise, deformidades crÃnio-faciais e fragilidade Ãssea. Aproximadamente 200 casos foram descritos em diferentes grupos Ãtnicos, estimando-se uma incidÃncia de 1,7: 1.000.0000 de nascidos. O uso da saliva como um mÃtodo de diagnÃstico avanÃou exponencialmente nos Ãltimos anos. DesequilÃbrios na quantidade e composiÃÃo da saliva podem gerar afecÃÃes bucais tais como cÃries e doenÃa periodontal, alÃm de ser indicativo de alteraÃÃo sistÃmica importante. Esse trabalho objetivou estudar parÃmetros de saliva total humana em pacientes portadores de picnodisostose (PYCN). A amostra consistiu em 04 indivÃduos com PYCN (grupo experimental) e 04 indivÃduos nÃo-sindrÃmicos (grupo controle), tendo sido avaliado fluxo salivar, pH e perfil protÃico. Saliva total nÃo estimulada foi coletada e centrifugada; o sobrenadante foi retido, liofilizado, armazenado a -20ÂC e analisado para contagem de proteÃnas totais e eletroforese bidimensional. Foi possÃvel detectar diferenÃas estatisticamente significativas entre os grupos (p<0,05) para os parÃmetros salivares analisados. Quando comparados com o grupo controle, portadores de PYCN apresentaram reduÃÃo no fluxo salivar; pH com valores aumentados; reduÃÃo na concentraÃÃo total de proteÃnas e bandas protÃicas com expressÃo diferenciadas. Os resultados desse estudo sugerem haver padrÃes diferenciados na composiÃÃo salivar entre os grupos avaliados.
Picnodysostosis (PKND) is a skeletal displasia characterized by short stature, osteosclerosis, acrosteolisis, craniofacial deformities and bone fragility. Approximately 200 cases have been described among different ethnic groups, with an estimated incidence of 1.7: 1.000.000 live births. The use of saliva as a diagnostic tool has advanced exponentially within recent years. Unbalance in the amount and composition of saliva may generate oral diseases such as dental caries and periodontitis, and may also indicate important systemic alterations. This study has aimed to investigate the parameters of human whole saliva in patients with PKND. Our study sample consisted of 4 individuals with PKND (experimental group) and 4 healthy individuals without PKND (control group). Salivary flow rate, pH and protein profile were evaluated in this population. Non stimulated whole saliva was collected and centrifuged. The supernatant was separated and lyophilized and stored at -20ÂC for posterior total protein and bidimensional electroforetic analysis. Statistically significant differences were observed between groups (p<0,05) for the analyzed salivary parameters. When compared to the control group, individuals with PKND presented reduced salivary flow rate, lower pH values, reduced total protein concentration, and protein bands with differentiated expression. The results of this study suggest the existence of a differentiated pattern of salivary composition between groups.
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Yuk-lun, Kam. "The efficacy of a novel lubricating system in the management of radiotherapy related xerostomia." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31981835.

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Dantas, Aline Maia. "Estudo da relação entre glândulas salivares e doença periodontal em ratos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-09022012-142657/.

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A gengivite e a periodontite constituem doenças periodontais infecciosas comuns do homem, nas quais as bactérias periodontais e seus produtos participam ativamente para indução da inflamação local e efeitos sistêmicos (ex.: coração). Sabendo que a saliva representa a primeira e grande barreira às infecções orais, este trabalho se propôs a: i) avaliar a perda óssea induzida pela doença periodontal em ratos submetidos à indução de doença, via implante de ligadura, após os intervalos de 3, 7 e 14 dias; ii) Investigar possíveis alterações de fluxo (estimulado ou não com pilocarpina) e composição salivar nesses animais; iii) avaliar a concentração / expressão de marcadores de estresse oxidativo e inflamatórios em glândulas salivares e em amostras de saliva; iv) avaliar o papel funcional da função das glândulas salivares ex-vivo na produção da amilase. Para isto, ratos Wistar machos (180 -200g) foram submetidos à indução da periodontite através do implante da ligadura, e os parâmetros inflamatórios e bioquímicos foram avaliados nesses animais. Ratos com periodontite no dia 3, quando comparado ao grupo sham, exibiram aumento significativo do fluxo salivar (estimulada com pilocarpina), produção de Ca2+, secreção de proteínas e produção de amilase na saliva, bem como aumento do conteúdo de TBARs em glândulas parótida e da amilase liberada das glândulas submandibulares (GSM). Observou-se, ainda, aumento da expressão de mRNA para iNOS e nNOS em GSM. Em contrapartida, ratos com periodontite após 7 dias exibiram redução da taxa de salivação estimulada (e não estimulada), da produção de proteínas totais e da concentração e secreção de amilase na saliva, muito embora o conteúdo sérico e salivar de TBARs e da atividade de MPO na saliva desses animais mostrou-se elevado em relação ao grupo sham. Não foram observadas diferenças significativas quanto ao conteúdo de TBARs em glândulas salivares, secreção e concentração de Ca2+ na saliva e tampouco sobre o conteúdo de proteínas nitradas em amostras de GSM desses animais. Já no 14° dia visualizou-se um aumento da atividade de NOS Ca2+ dependente e da expressão mRNA das iNOS e nNOS em GSM. Ratos com periodontite, após 14 dias de indução, não exibiram aumento significativo na taxa de salivação, concentração e secreção de Ca2+ salivar, produção e concentração de proteínas totais, amilase na saliva e conteúdo de TBARs em amostras de saliva e glândulas salivares. Ainda, observou-se aumento das atividades da peroxidase/MPO, concentração de nitrato em saliva e proteínas nitradas em GSM e maior concentração de citocinas Th1 / Th2 (IL-4, IL-13 e IL-10) em amostras de GSM. Conclui-se que a indução experimental da doença periodontal em ratos , influencia o funcionamento de glândulas salivares de acordo com os dias de indução, inicialmente estimulando, em um segundo momento inibindo e posteriormente retornando aos níveis basais. Após 7 dias, caracteriza-se como o tempo ideal para a manifestação dos efeitos inibitórios na glândula.
Gingivitis and periodontitis are common infectious periodontal diseases in man, in which periodontal bacteria and their products participate actively to induce local inflammation and systemic effects (eg heart). Knowing that saliva represents the first major barrier to oral infections, this study aimed to: i) to assess bone loss due to induced periodontitis in rats, after intervals of 3, 7 and 14 days, ii) to investigate possible changes in flow (or not stimulated with pilocarpine) and salivary composition in these animals, and iii) evaluate the concentration and expression of markers of oxidative stress and inflammation in the salivary glands and saliva samples, and iv) assess the functional role of salivary gland function in ex vivo production of amylase. For this purpose, male Wistar rats (180-200g) underwent induction of periodontitis by implanting the ligature, and biochemical and inflammatory parameters were assessed. Rats with periodontitis on day 3 when compared to sham group, exhibited a significant increase in salivary flow (stimulated with pilocarpine), production of Ca2+, protein secretion and production of amylase in saliva, as well as increased contents of TBARS in the parotid and amylase released from submandibular glands (GSM). There was also increased expression of mRNA for iNOS and nNOS in GSM. In contrast, rats with periodontitis after 7 days exhibited a reduction in stimulated saliva (not stimulated), production and total protein concentration and secretion of salivary amylase, although the content of serum and salivary TBARS and the activity of MPO in saliva of these animals was high compared to the sham group. There were no significant differences in TBARS content in salivary gland secretion and Ca2+ concentration in saliva, nor on the content of nitrated proteins in samples from these animals GSM. By the 14th day envisioned an increase of NOS activity and Ca2+ dependent mRNA expression of iNOS and nNOS in GSM. Rats with periodontitis, 14 days after induction, exhibited a significant increase in the rate of salivation, concentration and salivary secretion of Ca2+, production and concentration of total protein, salivary amylase and content of TBARS in samples of saliva and salivary glands. Still, there was increased activity of peroxidase / MPO, nitrate concentration in saliva and proteins nitrated in GSM and higher concentration of Th1 / Th2 (IL-4, IL-13 and IL-10) in samples of GSM. We conclude that the experimental induction of periodontal disease in rats, influence the functioning of the salivary glands according to the days of induction, initially stimulating, in a second time and subsequently inhibiting return to baseline levels. After 7 days, is characterized as the ideal time for the expression of an inhibitory effect on the gland function.
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Cachucho, Liliana Margarida Sargento. "Biomarcadores de aclimatação na saliva: estudo em vacas leiteiras com diferente potencial leiteiro." Master's thesis, Universidade de Évora, 2015. http://hdl.handle.net/10174/17555.

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O ambiente térmico a que um animal está sujeito é um fator importante, que pode afetar a produção de leite. A saliva é cada vez mais utilizada como fonte de biomarcadores não invasivos, sendo o cortisol salivar o parâmetro mais frequentemente utilizado para avaliar stresse. No entanto, este último, isoladamente, apresenta algumas limitações. No presente trabalho foi feita uma comparação do perfil proteico da saliva de vacas Holstein, altas (AP) e baixas produtoras (BP), em três períodos diferentes: temperaturas elevadas (P1), temperaturas moderadas (P2) e temperaturas baixas (P3). Foram observados níveis de expressão das proteínas albumina e receptor polimérico de imunoglobulinas mais elevados em AP, nos P1 e P2. Os níveis de cortisol salivar não se observaram associados a stresse térmico. Ainda que necessitando de estudos futuros, os resultados obtidos reforçam o potencial da saliva na avaliação da capacidade de adaptação à temperatura, em animais produtores de leite; Salivary biomarkers of acclimatization – study in dairy cows with different milk yield potential Abstract: The thermal environment is one of the most important factors that can affect milk production. Saliva is increasingly used as a source of non-invasive biomarkers, with salivary cortisol being the parameter most commonly used to evaluate stress. However, cortisol evaluation, alone, has some limitations. In this study a comparison was made, in terms of saliva composition, among Holstein cows with high (AP) and low (BP) productive potential, in three different periods: high temperature (P1), moderate temperatures (P2) and low temperatures (P3). Expression levels of proteins albumin and polymeric immunoglobulin receptor were observed to be higher in AP in P1 and P2. Salivary cortisol levels were not observed to be associated with thermal stress. Although requiring further studies, the results support the potential of saliva for assessing the ability to adapt to temperature in milk-producing animals.
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Sardinha, Daniela Abreu. "Xerostomia e hipofunção das glândulas salivares: fisiopatologia e enquadramento clínico." Master's thesis, [s.n.], 2013. http://hdl.handle.net/10284/5250.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária
A saliva desempenha múltiplas funções e tem um papel vital na proteção da saúde dos tecidos moles e duros da cavidade oral. A xerostomia é a sensação subjetiva de boca seca, um sintoma que pode ou não estar acompanhado de hipossalivação, descrita como redução do fluxo salivar estimulado ou não estimulado. Os pacientes com redução do fluxo salivar apresentam maior risco de cáries, infeções fúngicas orais, dificuldades na deglutição e alteração do paladar. As principais causas da hipofunção das glândulas salivares e da xerostomia são doenças sistémicas e os medicamentos. O diagnóstico é baseado em métodos simples, como a medição do fluxo salivar estimulado e não estimulado. Sendo que o tratamento da xerostomia é essencialmente realizado tendo em conta a sua causa e é dividido em quatro categorias: prevenção, tratamento sintomático, estimulação local ou tópica e terapias sistémicas ou estimulação sistémica. Cada categoria será aplicada dependendo da função glandular. Quando há alguma preservação da estrutura da GS os estimulantes salivares (estimulação local ou sistémica) são o mais indicado. Quando as GS encontram-se irreversivelmente danificadas a opção é o tratamento paliativo.
Saliva has multiple functions and plays a vital role in protecting the health of hard and soft tissues of the oral cavity. Xerostomia is the subjective sensation of dry mouth, a symptom that may or may not be accompanied by hyposalivation, described as a reduction of unstimulated and stimulated salivary flow. Patients with reduced salivary flow are at increased risk for caries, oral fungal infections, swallowing problems and altered taste. The principal causes of salivary gland hypofunction and xerostomia are systemic diseases and drugs. The diagnosis is based on simple methods, as measuring both unstimulated and stimulated salivary flow rate. Treatment of xerostomia essentially is carried out in regard to the cause and is divided in four main categories: palliative or symptomatic stimulation, local and systemic stimulation and prevention of complications. Which category will be applied, depending on salivary glands function. In cases when there is still some residual salivary function it was shown that saliva stimulans (local or systemic stimulation) is more appropriate. When salivary glands are irreversible damaged palliative treatment is the best option.
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Neves, Sandra. "Efeitos da hiperleptinémia na secreção de proteínas salivares." Master's thesis, Universidade de Évora, 2014. http://hdl.handle.net/10174/12228.

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Apesar da forte contribuição do sistema nervoso autónomo para a salivação, a influência de fatores hormonais não é de excluir. Alterações salivares em função do apetite/saciedade foram sugeridas por outros autores. Sendo a leptina uma hormona supressora de apetite, cuja presença de recetores nas glândulas salivares foi observada, o objetivo do presente trabalho é avaliar se aumentos nos níveis circulantes da mesma influenciam a salivação. Nos primeiros 3 dias de administração subcutânea de leptina observou-se uma diminuição do consumo de alimento, a qual deixou de se observar a partir daí e até ao fim dos 7 dias de ensaio. Apesar da concentração proteica e da taxa de secreção salivar se manterem semelhantes, foram observadas diferenças nos perfis proteicos salivares uni- e bi-dimensionais. Dos 15 spots proteicos diferencialmente expressos, um dos diminuídos situa-se numa zona anteriormente identificada como respeitante à amílase. Assim, a hiperleptinémia induz alterações no perfil proteico salivar; ### Abstract: Effects of hyperleptinemia in the secretion of proteins Salivary Despite the strong contribution of the autonomic nervous system to salivation, the influence of hormonal factors is not excluded. Changes in salivary function of appetite / satiety were suggested by other authors. Being one suppressing hormone leptin in appetite, whose presence of receptors in the salivary glands was observed, the aim of this study is to assess whether increases in circulating levels of the same influence salivation. In the first 3 days of subcutaneous administration of leptin was observed a decrease in food intake, which ceased to be observed thereafter until the end of the 7 days of testing. Although the protein concentration and the rate of salivary secretion remain similar, differences were observed in salivary protein profiles uni - and bi - dimensional. Of the 15 differentially expressed protein spots, one of diminished located in an area previously identified as relating amylase. Thus, hyperleptinemia induces changes in salivary protein profile.
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Camargo, Tarsila Mendes de 1982. "Caracterização do sistema de dois componentes SptRS de Streptococcus sanguinis com possível papel na viabilidade em saliva humana : Characterization of the component system SptRS of Streptococcus sanguinis with putative role in bacterial viability in human saliva." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288672.

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Orientador: Renata de Oliveira Mattos Graner
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
Made available in DSpace on 2018-08-24T21:23:04Z (GMT). No. of bitstreams: 1 Camargo_TarsilaMendesde_D.pdf: 3797669 bytes, checksum: f0bf38a8e753cc57e8da2546f30b5b31 (MD5) Previous issue date: 2014
Resumo: Streptococcus sanguinis é colonizador comensal da superfícies dos dentes e patógeno comum de endocardite bacteriana em seres humanos. A colonização da cavidade oral por S. sanguinis depende, em parte, de interações de superfície bacteriana com componentes adsorvidos na superfície dos dentes (que são principalmente de origem salivar) chamado película adquirida (PA). Além disso, os produtos do metabolismo aeróbio de S. sanguinis, por exemplo, peróxido de hidrogênio, inibe o crescimento de espécies de estreptococos concorrentes e promove a liberação de DNA genômico, um componente da matriz extracelular do biofilme dental. S. sanguinis se adapta fisiologicamente a saliva durante suas fases de colonização na cavidade oral, que provavelmente envolve alterações dinâmicas em seu transcriptoma. Transcriptomas bacterianos são regulados pelos sistemas de dois componentes (SDC), que consistem de uma membrana sensora de histidina quinase (HK) e um regulador de resposta intracelular cognato (RR). A HK sofre autofosforilação sob estímulos específicos e fosforila RR cognato, que por sua vez se liga às regiões reguladoras de genes alvo, induzindo ou reprimindo a transcrição. S. sanguinis SK36 tem um ortólogo de SDC SptRS designado (de Saliva persistência) envolvidos na sobrevivência e persistência na saliva humana em S. pyogenes. O objetivo deste estudo foi investigar o papel do SDC SptRS na biologia de S. sanguinis. Para isso, mutantes knockout de sptR (SKsptR-) e sptS (SKsptS-) foram obtidos a partir da cepa SK36. Mutantes sptRS foram analisados quanto ao crescimento planctônico e biofilme em meio suplementado ou não com saliva humana. Liberação de DNA, produção de peróxido de hidrogênio, autólise e sensibilidade ao stresse oxidativo também foram analisados nestas cepas. Alterações da transcrição dos genes associados a fenótipos observados foram avaliadas por meio de RT - qPCR. Sob aerobiose, mutantes sptRS formaram cadeias muito longas e agregados de cocos. O crescimento mais lento em comparação com SK36 também foi observado. Por outro lado, um aumento significativo (cerca de 2 vezes ) em biomassa do biofilme foram encontrados em mutantes em comparação com SK36 na presença de saliva. Consistentemente, mutantes liberaram 2 a 5 vezes mais DNA ao meio e produziram 2 a 3 vezes mais de H2O2 em comparação com a cepa selvagem. Não foram observadas alterações em autólise induzida por alta temperatura. Os mutantes mostraram um aumento da tolerância ao stresse oxidativo, mas reduções de 1 a 2 logs na contagem de células (ufc / ml ) durante a incubação em saliva. A análise de RT- qPCR revelou que SptRS regula negativamente os genes que codificam as hidrolases mureína (SSA_0094 e cwdP); aumentos de 2,14 e 14,7 vezes nestes genes foram respectivamente observados em mutantes SKsptR-. Além disso, nos mutantes sptRS foram observados aumentos de 15,5 a 27,9 vezes em transcritos do gene spxB, que codifica a oxidase piruvato necessária para a produção de H2O2. Outros genes associados com a produção H2O2 também foram afetados nos mutantes [ackA (aumento de 5,3-9,7 vezes); tpK (aumento de 12,19 vezes)]. Este estudo fornece evidências de que SptRS regula as funções de S. sanguinis de estabelecimento em biofilmes associados à produção de H2O2 e liberação de DNA, e participa da sobrevivência das bactérias na saliva humana
Abstract: Streptococcus sanguinis is commensal colonizer of tooth surfaces and common pathogen of bacterial endocarditis in humans. The colonization of the oral cavity by S. sanguinis depends in part, on bacterial surface interactions with components adsorbed to tooth surfaces (which are primarily of salivary origin) called acquired pellicle (AP). In addition, products of S. sanguinis aerobic metabolism, e.g. hydrogen peroxide, inhibits the growth of competitor streptococcal species and promotes the release of genomic DNA, a component of the extracellular matrix of dental biofilms. S. sanguinis physiological adaptation to saliva during the stages of colonization of the oral cavity, likely involves dynamic changes in its transcriptome. Bacterial transcriptomes are regulated by two-component systems (TCS), which consist of a membrane sensor histidine kinase (HK) and a cognate intracellular response regulator (RR). The HK undergoes autophosphorylation under specific stimuli and phosphorylates the cognate RR, which in turn binds to regulatory regions of target genes, inducing or repressing transcription. S. sanguinis SK36 strain has an orthologue of the TCS designated SptRS (of Saliva persistence) involved in survival and persistence in human saliva in S. pyogenes. The aim of this study was to investigate the role of SptRS TCS in S. sanguinis biology. To that purpose, knockout mutants of sptR (SKsptR-), and sptS (SKsptS-) genes were obtained in strain SK36. SptRS mutants were analyzed regarding to planktonic and biofilm growth in medium supplemented or not with human saliva. DNA release, production of hydrogen peroxide, autolysis and sensitivity to oxidative stress were also analyzed in these strains. Transcriptional changes in genes associated with observed phenotypes were then assessed by RT-qPCR. Under aerobiosis, sptS/R mutants formed extremely long chains and aggregates of cocci. Slower growth compared to SK36 was also observed. On the other hand, significant increases (about 2-fold) in biofilm biomass were found in mutants compared to SK36 in the presence of saliva. Consistently, mutants released 2 to 5-fold more DNA to medium and produced 2 to 3-fold more H2O2 compared to parent strain. No changes were observed in autolysis induced by high temperature. Mutants showed increased tolerance to oxidative stress, but reductions of 1 to 2 logs in cell counts (cfu/ml) during incubation in saliva. RT- qPCR analysis revealed that SptRS negatively regulates genes encoding murein hydrolases (SSA_0094 and cwdP); increases of 2.14 and 14.7-folds in these genes were respectively observed in SKsptR mutants. In addition, 15.5 to 27.9-fold increases in sptR/S mutants were observed in spxB transcripts, which encode pyruvate oxidase required for H2O2 production. Other genes associated with H2O2 production were also affected in mutants [ackA (5.3 to 9.7-fold increases; tpK (12.19-fold increase)]. This study provides evidence that SptRS regulates functions for S. sanguinis establishment in biofilms associated with H2O2 production and DNA release, and participates in bacterial survival in human saliva
Doutorado
Microbiologia e Imunologia
Doutora em Biologia Buco-Dental
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Nogueira, Ferrada Florencia María. "Comparación de velocidad de flujo salival, pH salival y concentración de proteínas en saliva entre sujetos con diabetes mellitus tipo 2 compensados y descompensados." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/137621.

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Trabajo de Investigación Requisito para optar al Título de Cirujano Dentista
Introducción. La Diabetes Mellitus es una enfermedad metabólica caracterizada por una hiperglicemia crónica causada por la acción o producción deficiente de la insulina. En el curso de esta enfermedad y de acuerdo al grado de descompensación metabólica expresada en valores de hemoglobina glicosilada (HbA1c), surgen complicaciones sistémicas y manifestaciones orales. Dentro de estas últimas, se encuentran las alteraciones de parámetros cuantitativos y cualitativos salivales, afectando la calidad de vida de los pacientes e incrementando la susceptibilidad a desarrollar patologías orales como caries y candidiasis oral. Existe escasa evidencia que relacione características salivales en diabéticos con sus niveles de HbA1c, por lo que el objetivo de este estudio fue comparar la velocidad de flujo salival, pH salival, concentración de proteínas en saliva y presencia de xerostomía entre sujetos con Diabetes Mellitus tipo 2 (DM2) compensados (Hb1Ac < 7%) y descompensados metabólicamente (Hb1Ac ≥ 7%). Metodología. Este trabajo incluyó a 50 voluntarios con DM2, pertenecientes a la Asociación De Diabéticos de Chile (ADICH), de los cuales 25, correspondían a descompensados metabólicamente (grupo experimental) y los otros 25, a compensados (grupo control). Se realizó una ficha clínica que incluía el cuestionario para la xerostomía y se tomaron muestras salivales en las cuales se analizaron la velocidad de flujo salival, pH salival y concentración total de proteínas en saliva. Resultados. La concentración total de proteínas en saliva fue mayor en diabéticos descompensados que en compensados, con diferencias estadísticamente significativas. Por otro lado, para la comparación de velocidad de flujo salival, pH salival y xerostomía, no se encontraron diferencias significativas entre ambos grupos de estudio. Conclusiones. En este trabajo, la concentración total de proteínas salivales fue significativamente mayor en sujetos con DM2 con valores de HbA1c ≥ 7%, en comparación con sujetos con HbA1c < 7%, lo que podría ser un indicador de descompensación metabólica en diabéticos o de disfunción de glándulas salivales. Sin embargo, son necesarios más estudios futuros para esclarecer el verdadero rol de la saliva en el diagnóstico y control de la DM2.
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Roy, Kirsty McLiver. "Hepatitis C virus in saliva." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297005.

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Books on the topic "Saliva"

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Plensa, Jaume. Chaos-Saliva. Madrid: Museo Nacional Centro de Arte Reina Sofía, 2000.

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Araya, Juan Gabriel. Tragar saliva. Santiago de Chile: Ediciones Todavía, 1996.

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Ligtenberg, Antoon J. M., and Enno C. I. Veerman. Saliva: Secretion and functions. Basel: Karger, 2014.

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1922-, Sreebny Leo M., ed. The Salivary system. Boca Raton, Fla: CRC Press, 1987.

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M, Edgar W., Dawes Colin Ph D, and O'Mullane D. M, eds. Saliva and oral health. 3rd ed. London: British Dental Association, 2004.

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Smith, Dean Wesley. The green saliva blues. New York: Bantam Books, 1999.

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Pena, Ana Elena. Hago pompas con saliva. [Barcelona, Spain]: Melusina, 2011.

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Plensa, Jaume. Jaume Plensa: Chaos-saliva. Madrid: Museo Nacional Centro de Arte Reina Sofía, 2000.

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M, Edgar W., and O'Mullane D. M, eds. Saliva and oral health. 2nd ed. London: British Dental Association, 1996.

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La saliva dels morts. Barcelona: Edicions Proa, 2018.

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Book chapters on the topic "Saliva"

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Levine, Martin. "Saliva." In Topics in Dental Biochemistry, 203–30. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-88116-2_12.

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Heppner, John B., David B. Richman, Steven E. Naranjo, Dale Habeck, Christopher Asaro, Jean-Luc Boevé, Johann Baumgärtner, et al. "Saliva." In Encyclopedia of Entomology, 3230. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_4007.

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Mesko, D. "Saliva." In Differential Diagnosis by Laboratory Medicine, 514–15. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-642-55600-5_13.

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Min, Byung-Moo. "Saliva." In Oral Biochemistry, 99–124. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-3596-3_7.

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Mandel, Louis. "Saliva." In Clinical Management of Salivary Gland Disorders, 17–46. Cham: Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-50012-1_2.

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Stokes, Jason R. "Saliva Lubrication." In Encyclopedia of Tribology, 2971–77. Boston, MA: Springer US, 2013. http://dx.doi.org/10.1007/978-0-387-92897-5_1270.

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Coffey, Charley. "Saliva Management." In Neurologic and Neurodegenerative Diseases of the Larynx, 307–21. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-28852-5_26.

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Cheng, Jordan, Taichiro Nonaka, Qianlin Ye, Fang Wei, and David T. W. Wong. "Salivaomics, Saliva-Exosomics, and Saliva Liquid Biopsy." In Salivary Bioscience, 157–75. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-35784-9_8.

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Mellema, J., H. J. Holterman, E. J. s-Gravenmade, H. A. Waterman, and C. Blom. "Rheology of Human Saliva and Saliva Substitutes." In Third European Rheology Conference and Golden Jubilee Meeting of the British Society of Rheology, 352–54. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-009-0781-2_122.

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Agni, Nisheet Anant. "Salivary Gland Pathologies." In Oral and Maxillofacial Surgery for the Clinician, 939–73. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-1346-6_46.

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AbstractSaliva is responsible for various functions from lubrication to digestion. The saliva is secreted by numerous minor and major salivary glands. These salivary glands are sometimes affected by various local and systemic inflammatory conditions, obstructive pathologies with benign and malignant tumors. This chapter deals with various pathologies of salivary glands and their management.
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Conference papers on the topic "Saliva"

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Castro-Ramos, J., H. N. Chavarría-Lizárraga, R. Bruzual-Roa, and F. Narea-Jiménez. "Determination of chronic degenerative diseases by Raman spectroscopy, principal component analysis, and saliva biomarkers." In Frontiers in Optics. Washington, D.C.: Optica Publishing Group, 2023. http://dx.doi.org/10.1364/fio.2023.jm4a.25.

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We analyzed saliva samples' Raman spectra. We analyze the Raman spectra of salivary biomarkers such as albumin, alanine aminotransferase, cortisol, and melatonin. With the peaks found in the saliva spectrum, we associate them with chronic degenerative diseases.
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Wexler, PW, D. Delgado, WL Siqueira, EJ Helmerhorst, R. Lomasky, CE Brodley, TM Blicharz, et al. "Saliva Diagnostics in Asthma." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2873.

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Rissin, David M., Christopher DiCesare, Ryan B. Hayman, Timothy M. Blicharz, and David R. Walt. "Microsphere based saliva diagnostics." In Optics East 2005, edited by Brian M. Cullum and J. Chance Carter. SPIE, 2005. http://dx.doi.org/10.1117/12.630781.

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Takahashi, Nozomi, Hiromi Nakamura, Takuji Narumi, Michitaka Hirose, and Kazuma Aoyama. "Electrical Stimulation Promotes Saliva Secretion: Proposition of Novel Interaction via Saliva Secretion." In CHI '20: CHI Conference on Human Factors in Computing Systems. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3334480.3382952.

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Thaweboon, Sroisiri, Ratchaporn Srichan, Supaporn Mala, and Boonyanit Thaweboon. "The Development of Artificial Saliva with Oral Wound Healing Property." In 2023 7th International Conference on Nanomaterials and Biomaterials & 2023 5th Asia Conference on Material and Manufacturing Technology. Switzerland: Trans Tech Publications Ltd, 2024. http://dx.doi.org/10.4028/p-wc6acn.

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Wound healing is a normal biological mechanism of the body that helps to maintain the integrity of the tissue. In this process, fibroblasts play an important role in supporting wound healing by migrating to the injury site and laying down a new extracellular matrix. Oral wounds heal more rapidly than skin wounds due to the presence of saliva. However, a reduced salivary flow rate or hyposalivation is frequently found in some patients due to their systemic conditions or intake of various medications. In order to control or treat hyposalivation, the use of artificial saliva is recommended for these patients. Various agents were added to artificial saliva to improve its properties. The aim of the present study was to investigate the effect of artificial saliva containing vanillin on the wound healing of human gingival fibroblasts by inducing cell migration in vitro. Human gingival fibroblasts isolated from human gingiva were purchased from Scien Cell Research Laboratories, USA. The migratory ability of fibroblasts was performed on a confluent monolayer by the wound healing scratch assay. Artificial saliva with different concentrations of vanillin (0.12% to 4% w/v) was added and incubated for 24 h. Artificial saliva without vanillin was used as a control. The migration cells were fixed with 25% methanol and 0.2% toluidine blue. In vitro cell migration to the wound area was determined by photographing with an inverted microscope coupled to a digital camera (Nikon D 5100). In the presence of 0.25%, 0.5%, and 1% w/v vanillin-containing artificial saliva, human gingival fibroblasts had a significantly higher potential to migrate into the wound area than a control (p-value <0.05). Data from this study provides the first scientific evidence to demonstrate the benefits of using artificial saliva containing vanillin to maintain healthy gums and accelerate oral wound healing. Rinsing the mouth with this artificial saliva is recommended as the most preferable method for moistening and lubricating the mouth and facilitating the healing of oral wounds in patients with hyposalivation.
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Nikonov, G., and I. Baskova. "PROTECTIVE ANTITHROMBOTIC ACTION OF THE PREPARATIONS FROM THE LEECHES HIRUDO MED ICINAL IS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643079.

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Blood letting effect of the medicinal leeches is provided by antihaemostatic properties of the salivary gland secretion. We have demonstrated that the natural salivary gland secretion inhibits the vascular-platelets haemostasis and the contact stage of the intrinsic mechnism of blood coagulation but has no effect on the activation of extrinsic mechanism (Bui 1.Exp.Biol.Med.USSR 97, 6, 696; 8, 142, 1984). Leech prostaglandins (Dokl.Acad.Nauk USSR, 1987) and inhibitors of plasma kallikrein and Factor XI la are the main anti haemostatic agents of the leech saliva.The leech saliva does not change the main parameters of blood coagulation of the healthy animals, such as recalcification time, cephalin time, thrombin and prothrombin time 5, 15 and 25 min after intravenous injection. But the platelets aggregation stimulated by thrombin is diminished by 20% (n=30;p 0,02) Recalcification time, cephalin time and platelets aggregation reduced by intravenous injection of human serum is corrected by leech saliva.As the trigger mechanisms of haemostasis are very much alike the trigger mechanisms of thrombogenes?s, we investigated antithrombotic ability of the leech saliva, extracts of dried leeches and blood of intestinal gut. We used Wessler procedure of throm-bous formation in rats.The thrombous formation was diminished by 90% compared to control when 0.3 ml of the leech saliva (diluted with saline 1:4) was injected intravenously 2-4 hrs before injection of human serum. Thrombous formation was diminished by 40% when time interval was elongated to 24-28 hrs. Antithrombotic effect does not depend on the antithrombin activity of hirudin. It slightly decreased in case of oral administration and increased after the multiple intravenous injections or oral administration.Blood from the leech intestinal tract and other preparations from the leeches exhibit less distinct antithrombotic effect than the salivatory gland secretion.
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Griffin, Timothy J. "Human saliva proteome: an overview." In SPIE Sensing Technology + Applications, edited by Šárka O. Southern, Mark A. Mentzer, Isaac Rodriguez-Chavez, and Virginia E. Wotring. SPIE, 2014. http://dx.doi.org/10.1117/12.2058731.

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Griffin, Timothy J. "The proteome of human saliva." In SPIE Defense, Security, and Sensing, edited by Šárka O. Southern. SPIE, 2013. http://dx.doi.org/10.1117/12.2020012.

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Wohkittel, C., M. Romanos, A. Diehl, P. Högger, and M. Gerlach. "Influence of saliva pH-value on the ratio of amphetamine saliva to serum concentration." In Abstracts of the 1st Symposium of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) and Deutsche Gesellschaft für Biologische Psychiatrie (DGBP). Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1679172.

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Wohkittel, C., M. Romanos, P. Högger, and M. Gerlach. "Influence of saliva pH-value on the ratio of amphetamine saliva to serum concentration." In XIIIth Symposium of the Task Force Therapeutic Drug Monitoring of the AGNP. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1649542.

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Reports on the topic "Saliva"

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Logue, Brian A., Michael W. Stutelberg, Erica Manandhar, Joseph K. Dzisam, Brendan L. Mitchell, Randy E. Jackson, Wenhui Zhou, Robert P. Oda, and Raj K. Bhandari. Rapid Field-Usable Cyanide Sensor Development for Blood and Saliva. Fort Belvoir, VA: Defense Technical Information Center, December 2014. http://dx.doi.org/10.21236/ada621259.

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Ren, Jiayi, Bai Li, Huantian Cao, and Michele Lobo. The Design of Saliva Wicking Scarves for Individuals with Oral Motor Impairments. Ames (Iowa): Iowa State University. Library, January 2019. http://dx.doi.org/10.31274/itaa.8763.

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Blunk, Sara, Ricardo Torres, Leticia Bemben, Mirella Manosso, and Paulo Soares. Tribological behavior of WC/C coated AISI 420 steel in artificial saliva. Peeref, April 2023. http://dx.doi.org/10.54985/peeref.2304p9756340.

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Silks, III, Louis A. Methods for transfer a saliva based alcohol content test to a dermal patch. Office of Scientific and Technical Information (OSTI), January 2017. http://dx.doi.org/10.2172/1338719.

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Souza, Vívian, Lara Araújo, Rodrigo Fabri, Laísa Laxe, and Ana Apolônio. Characteristics of aerosol and saliva droplets from dental care: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2020. http://dx.doi.org/10.37766/inplasy2020.7.0075.

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Hidayat, Rachmat, Patricia Wulandari, and Lusia Hayati. Does Cognitive Behavioural Therapy Affect Perceived Stress, Anxiety-depression Scores and Saliva Cortisol in Depression? "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, March 2021. http://dx.doi.org/10.7546/crabs.2021.03.17.

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Burdette, Alexander J., and Rene Alvarez. Evaluation of Innate Immune Biomarkers in Saliva for Diagnostic Potential of Bacterial and Viral Respiratory Infection. Fort Belvoir, VA: Defense Technical Information Center, February 2014. http://dx.doi.org/10.21236/ada602373.

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Cuevas, Christian, Jennifer De Lurio, Andrew Furman, Randy Hulshizer, Marcus Lynch, and Prital Patel. PCORI COVID-19 Scan: BinaxNOW COVID-19 Ag Card, Saliva-based Nucleic Acid Assays (September 3-16, 2020). Patient-Centered Outcomes Research Institute (PCORI), September 2020. http://dx.doi.org/10.25302/bcs9.2020.9.

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Michelmore, Richard, Eviatar Nevo, Abraham Korol, and Tzion Fahima. Genetic Diversity at Resistance Gene Clusters in Wild Populations of Lactuca. United States Department of Agriculture, February 2000. http://dx.doi.org/10.32747/2000.7573075.bard.

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Genetic resistance is often the least expensive, most effective, and ecologically-sound method of disease control. It is becoming apparent that plant genomes contain large numbers of disease resistance genes. However, the numbers of different resistance specificities within a genepool and the genetic mechanisms generating diversity are poorly understood. Our objectives were to characterize diversity in clusters of resistance genes in wild progenitors of cultivated lettuce in Israel and California in comparison to diversity within cultivated lettuce, and to determine the extent of gene flow, recombination, and genetic instability in generating variation within clusters of resistance genes. Genetic diversity of resistance genes was analyzed in wild and cultivated germplasm using molecular markers derived from lettuce resistance gene sequences of the NBS-LRR type that mapped to the major cluster if resistance genes in lettuce (Sicard et al. 1999). Three molecular markers, one microsatellite marker and two SCAR markers that amplified LRR- encoding regions, were developed from sequences of resistance gene homologs at the Dm3 cluster (RGC2s) in lettuce. Variation for these markers was assessed in germplasm including 74 genotypes of cultivated lettuce, L. saliva and 71 accessions of the three wild Lactuca spp., L. serriola, L. saligna and L. virosa that represent the major species in the sexually accessible genepool for lettuce. Diversity was also studied within and between natural populations of L. serriola from Israel and California. Large numbers of haplotypes were detected indicating the presence of numerous resistance genes in wild species. We documented a variety of genetic events occurring at clusters of resistance genes for the second objective (Sicard et al., 1999; Woo el al., in prep; Kuang et al., in prepb). The diversity of resistance genes in haplotypes provided evidence for gene duplication and unequal crossing over during the evolution of this cluster of resistance genes. Comparison of nine resistance genes in cv. Diana identified 22 gene conversion and five intergenic recombinations. We cloned and sequenced a 700 bp region from the middle of RGC2 genes from six genotypes, two each from L. saliva, L. serriola, and L. saligna . We have identified over 60 unique RGC2 sequences. Phylogenetic analysis surprisingly demonstrated much greater similarity between than within genotypes. This led to the realization that resistance genes are evolving much slower than had previously been assumed and to a new model as to how resistance genes are evolving (Michelmore and Meyers, 1998). The genetic structure of L. serriola was studied using 319 AFLP markers (Kuang et al., in prepa). Forty-one populations from Turkey, Armenia, Israel, and California as well as seven European countries were examined. AFLP marker data showed that the Turkish and Armenian populations were the most polymorphic populations and the European populations were the least. The Davis, CA population, a recent post-Columbian colonization, showed medium genetic diversity and was genetically close to the Turkish populations. Our results suggest that Turkey - Armenia may be the center of origin and diversity of L. serriola and may therefore have the greatest diversity of resistance genes. Our characterization of the diversity of resistance genes and the genetic mechanisms generating it will allow informed exploration, in situ and ex situ conservation, and utilization of germplasm resources for disease control. The results of this project provide the basis for our future research work, which will lead to a detailed understanding of the evolution of resistance genes in plants.
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Pirone, Thomas P., Benjamin Raccah, and Nor Chejanovsky. Vector Specificity in Potyvirus Transmission: Role of the Helper Component. United States Department of Agriculture, January 2003. http://dx.doi.org/10.32747/2003.7586456.bard.

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Objectives: The overall objective of this research was to gain a better understanding of how potyviruses interact with their aphid vectors. The aim was to design new approaches for prevention of potyvirus spread by aphids. The sub-objectives included: (1). Determination of which of the HCs of different potyviruses effect efficient transmission by specific aphid vectors; (2). Determine regions in the HC that play a role in their compatibility with the vector; (3). Determine the factors within the aphid stylets that modify HC activity in transmission. Background of the topic: Background to the topic: Potyviruses are typical non persistent viruses. They are retained within the vector’s stylets and rapidly lost by the vector. Some potyviruses greatly differ in their ability to be transmitted by different aphid species. The present work centered on analyzing factors that may modify the interactions between the "helper component"(HC), the virions and the aphid species involved. Major conclusions, solutions and achievements: It was established that specificity of transmission may depend on aphid species used. It was also shown that specificity may depend on the affinity between HC and virion. However, the attempts to create activechimericTEV/TuMVHCs or ZYMV/TuMVHCs to identify the regions that determine interaction with a specific vector(s), were not successful. More progress was attained in objective 3: In Kentucky, tests were conducted to ascertain retention tobacco vein mottling virus (TVMV) HC in the stylets of L. erysimicompared to that in M. persicae. Ultra-thin section of stylets of aphids that fed on either TuMVHC or TVMVHC antibodies were treated with gold-labeled goat anti-rabbit antibodies.TuMV was seen in 25% the stylets of L. erysimi when they acquired TuMVHC but not when they acquired TVMVHC. In M. persicae, TVMVHC was present in 30% of the stylets. . Transmission with TuMVHC was not affected by treatment with L. erysimi saliva whereas transmission with PVYHC (which also is not functional in L. erysimi) was consistently reduced by about half. Saliva from M. persicaehad essentially no effect on either HC. The possible role aphid cuticle proteins (which are found on the stylets surface) in the association with the potyviralHC was investigated in Israel. This was done adopting two approaches: (a) isolation of cuticular proteins from aphid cuticle; (b) screening for genes encoding cuticular proteins. In the first approach, we succeeded in extracting proteins from whole homogenized M. persicaeusing concentrated urea. The extracted protein served for preparation of anti cuticular antibodies. In overlay experiments it was found that cuticular proteins specifically bind to ZYMVHC. In addition, a cDNA library of M. persicae has been prepared. Genes encoding for cuticular proteins were ascertained using antibodies to cuticular proteins. This allowed reporting the sequence of the first cuticular gene of aphids and comparing it in six aphid species. Implications, scientific and agricultural: Achievements: (1) Proofs were provided for the role of the specificity of the aphid species to the HC of certain potyviruses; (2) aphid’s saliva was found to affects transmission efficiency; (3) cuticle protein genes were isolated for the first time from aphid species and an association of cuticle protein with the potyviralHC was discerned. Agricultural and/or economic impact of the research findings: At this stage of research, our finding do not bear an agricultural or economic impact.
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