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Dissertations / Theses on the topic 'Saccharomyces cerevisiae, cell cycle, Snf1'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

BUSNELLI, SARA. "Protein Kinase Snf1/AMPK: a new regulator of G1/S transition in Saccharomyces cerevisiae." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/40994.

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The AMP-activated protein kinase (AMPK) family is a group of Serine/Threonine kinases highly conserved in eukaryotes, from yeast and insects to plants and mammals. Their primary role is the integration of signals regarding nutrient availability and environmental stresses, ensuring the adaptation to those conditions and cell survival (Hardie G., 2007; Ghillebert R. et al., 2011). As its homologue AMPK, in Saccharomyces cerevisiae Snf1 exists as a heterotrimeric complex. Core of this enzyme is the catalytic α subunit (Snf1), made up of a canonical catalytic domain in its N-terminus and of an aut

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2

NICASTRO, RAFFAELE. "Role of Snf1/AMPK as regulator of cell cycle, signal transduction and metabolism in Saccharomyces cerevisiae." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/68465.

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Snf1 è una serina/treonina chinasi necessaria per il lievito S. cerevisiae per la crescita in condizioni di limitazione di nutrienti e per l’utilizzo di fonti di carbonio alternative al glucosio. Nel nostro laboratorio è stato precedentemente dimostrato che la mancanza di Snf1 causa un difetto nella transizione G1/S del ciclo cellulare e un difetto nell’espressione dei geni di fase G1 anche in condizioni di sufficienza nutrizionale (2% glucosio). È stato quindi approfondito il coinvolgimento di Snf1 in tre importanti processi cellulari: ciclo, trasduzione del segnale e metabolismo. Per dimos

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3

Kiser, Gretchen Louise. "Cell cycle checkpoint control in budding yeast Saccharomyces cerevisiae." Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/187074.

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Multiple checkpoint controls ensure that later cellular events are not initiated until previous cellular events have been successfully completed. Our laboratory studies the checkpoint at the G2/M boundary that ensures the integrity of chromosome transmission by blocking mitosis until DNA synthesis and repair is completed. The checkpoint-dependent cell division arrest is one of several prominent responses to DNA damage, which also includes transcriptional induction of damage-inducible genes and DNA repair. I undertook three projects that explore several aspects of the damage response: (1) I fur

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4

Gooding, Christopher Michael. "Mitochondrial DNA replication and transmission in Saccharomyces cerevisiae." Thesis, University of Hertfordshire, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303447.

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5

Chotai, Dipti. "Cell cycle regulated expression of the DBF2 gene in Saccharomyces cerevisiae." Thesis, University of Hertfordshire, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359005.

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6

Bahman, A. M. "Studies on the CDC7 gene product of Saccharomyces cerevisiae." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233154.

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7

Mapa, Claudine E. "Identification of Deubiquitinating Enzymes that Control the Cell Cycle in Saccharomyces cerevisiae." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/1004.

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A large fraction of the proteome displays cell cycle-dependent expression, which is important for cells to accurately grow and divide. Cyclical protein expression requires protein degradation via the ubiquitin proteasome system (UPS), and several ubiquitin ligases (E3) have established roles in this regulation. Less is understood about the roles of deubiquitinating enzymes (DUB), which antagonize E3 activity. A few DUBs have been shown to interact with and deubiquitinate cell cycle-regulatory E3s and their protein substrates, suggesting DUBs play key roles in cell cycle control. However, in vi

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8

Mitteau, Romain. "Régulation par la phosphorylation d’un module Rho GTPase dans la levure Saccharomyces cerevisiae." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22084/document.

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Le cycle cellulaire eucaryote est caractérisé par des changements abrupts et dynamiques de la polarité cellulaire lorsque les chromosomes sont dupliqués et ségrégés. Ces évènements nécessitent une coordination entre la machinerie du cycle cellulaire et les régulateurs de la polarité. Les mécanismes qui contrôlent cette coordination ne sont pas totalement compris. Dans la levure S. cerevisiae, comme dans d’autres organismes eucaryotes, la GTPase Cdc42 joue un rôle important dans la régulation de la polarité cellulaire. En effet ses régulateurs constituent un module GTPase qui subit une phosphor

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9

Schaefer, Jonathan Brook. "Regulation of G1 exit by the Swi6p transcription factor /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5080.

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10

Dieckhoff, Patrick. "Protein modification and degradation in the cell cycle of the yeast Saccharomyces cerevisiae." Doctoral thesis, [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972638644.

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11

Pic-Taylor, Aline. "The regulation of the cell division cycle by forkhead proteins in Saccharomyces cerevisiae." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341787.

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12

Miller, Kristi E. "Negative Regulation of Polarity Establishment in Saccharomyces cerevisiae." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555329407450767.

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13

Harris, M. R. "G1/S transcriptional regulation in Saccharomyces cerevisiae integrates cell cycle progression and genome stability." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1419003/.

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Saccharomyces cerevisiae provides an ideal model to study the regulation of cell cycle commitment due to the high conservation of signalling pathways and regulatory modules through to higher eukaryotes. My work investigates the interplay of cell cycle progression and arrest via the action of transcription factor regulation. Cell cycle commitment is controlled by the cyclin-dependent activation of transcription factor complexes, MBF and SBF. Here I describe the dynamics of SBF and MBF using new polyclonal anti-sera against the three key components Mbp1, Swi4 and Swi6, and their interaction with

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14

Venning, Bruce Martyn. "Cloning and characterization of an osmotically dependent suppressor of the cdc4 mutation of Saccharomyces cerevisiae." Thesis, University of Manchester, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257467.

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15

Atkins, Benjamin David. "Inhibition of Cdc42 during mitotic exit is required for cytokinesis in Saccharomyces cerevisiae." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11257.

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Rho GTPases are highly conserved regulators of cell polarity and the actin cytoskeleton. The role of the Rho GTPase Cdc42 and its regulation during cell division is not well understood. Using biochemical and imaging approaches in budding yeast, I demonstrate that Cdc42 activation peaks during the G1/S transition and during anaphase, but drops during mitotic exit and cytokinesis. Cdc5/Polo kinase is an important upstream cell cycle regulator that suppresses Cdc42 activity. Failure to downregulate Cdc42 during mitotic exit prevents the normal localization of key cytokinesis regulators - Iqg1 and

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16

Calzone, Laurence. "Temporal organization of the budding yeast cell cycle: general principles and detailed simulations." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/11070.

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The budding yeast cell cycle has attracted attention from many experimentalists over the years for its simplicity and amenability to genetic manipulation. Moreover, the regulatory components described in budding yeast, Saccharomyces cerevisiae, are conserved in higher eukaryotes. The budding yeast cell cycle is governed by a complex network of chemical reactions controlling the activity of the cyclin-dependent kinases (CDKs), proteins that drive the major events of the cell cycle. The presence of these proteins is required for the transition from G1 to S phase (Start) whereas their absence

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17

Adrover, Nadal Miguel Angel. "Qualitative and quantitative study of the effect of osmotress on cell cycle of Saccharomyces cerevisiae." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7211.

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Control of cell cycle by Stress Activated Protein Kinases (SAPKs) is an essential aspect for adaptation to extracellular stimuli. In Saccharomyces cerevisiae, the activation of the Hog1 SAPK, results in a delayed transcription of the G1 cyclins CLN1,2 and the stabilization of the B-type cyclin inhibitor SIC1, therefore postponing entry into S phase. The results displayed here, show, by a combination of mathematical modelling and quantitative in vivo experiments, that, before Start, the control of G1-S transition is mainly exerted by inhibiting expression of cyclins, both G1 (CLN1,2) and S phas

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18

Doris, Kathryn S. "The regulation of the cell division cycle in response to oxidative stress in Saccharomyces cerevisiae." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493072.

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19

O'Callaghan, Peter. "The regulation of the cell division cycle of Saccharomyces cerevisiae by the oxidative stress response." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413942.

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20

Pala, Prashna Jatindra. "Biochemical and biophysical characterisation of the Saccharomyces cerevisiae cell-cycle transcription factors, SBF and MBF." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271258.

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21

Andalis, Alexis Albert 1973. "Polyploidy in Saccharomyces cerevisiae leads to the loss of cell cycle control in stationary phase." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29783.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2003.<br>Includes bibliographical references.<br>Advances in genome sequencing and comparative genomics have uncovered ancient duplications in the genomes of many extant organisms. Evidence for large regional duplications is observed in eukaryotic organisms that include yeast, plants, fish, and humans. Furthermore, phylogenetic analysis of paralogous duplications within these organisms provides support for a single duplication event of the entire genome. The prevalence of genomic duplications lends credence to proposals

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22

Liu, Natalie, Charles W. Putnam, and Jesse D. Martinez. "Modeling Cell Cycle Effects of Human 14-3-3 Tumor Promoting Proteins in Saccharomyces Cerevisiae." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/244407.

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In this study, we used budding yeast as a model organism to examine the effects of overexpression of Bmh1, a yeast homolog of 14-3-3γ. We found that in the presence of modest DNA damage, Bmh1 overexpression had its most prominent effect during G2/M-phase of the cell cycle. We also observed that overexpression of Bmh1 concurrent with the induction of DNA damage partially rescued the G2/M arrest defect caused by the absence of Rad9, a key component of the G2/M DNA damage checkpoint pathway. When RAD53, a gene in the "Rad53 pathway" of the G2/M checkpoint, was deleted, overexpression of Bmh1 had

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23

BUSTI, STEFANO. "Glucose and regulation of cell cycle in saccharomyces cerevisiae: analisys of mutans impaired in sugar uptake mechanisms." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/7482.

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Glucose and regulation of cell cycle in S. cerevisiae: analysis of mutants impaired in sugar uptake mechanisms Requisito fondamentale per la sopravvivenza di microrganismi a vita libera come il lievito S. cerevisiae è la capacità di regolare il proprio metabolismo e la progressione del ciclo cellulare in modo tale che la crescita sia rapida in presenza di abbondanti nutrienti e si arresti all’esaurirsi degli stessi. Perché questo sia possibile, nutrienti come il glucosio devono generare segnali che vengano recepiti ed elaborati dal complesso macchinario che governa il ciclo cellulare. S. cer

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24

Münzner, Ulrike Tatjana Elisabeth. "From birth to birth A cell cycle control network of S. cerevisiae." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18566.

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Der Zellzyklus organisiert die Zellteilung, und kontrolliert die Replikation der DNA sowie die Weitergabe des Genoms an die nächste Zellgeneration. Er unterliegt einer strengen Kontrolle auf molekularer Ebene. Diese molekularen Kontrollmechanismen sind für das Überleben eines Organismus essentiell, da Fehler Krankheiten begüngstigen können. Vor allem Krebs ist assoziiert mit Abweichungen im Ablauf des Zellzyklus. Die Aufklärung solcher Kontrollmechanismen auf molekularer Ebene ermöglicht einerseits das Verständnis deren grundlegender Funktionsweise, andererseits können solche Erkenntnisse

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25

Escoté, Miró Xavier. "Control of cell cycle progression by the last MAPK Hog1." Doctoral thesis, Universitat Pompeu Fabra, 2005. http://hdl.handle.net/10803/7186.

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Exposure of yeast to increases in extracellular osmolarity activates the stress-activated Hog1 MAP kinase, which is essential for cell survival upon osmotic stress. Activation of the Hog1 MAPK results in cell growth arrest, suggesting a possible role of the MAP kinase in the control of the cell cycle. Our results have shown that Hog1 activation resulted in accumulation of cells in the G1/S and G2/M transitions. At G1, Hog1 regulates the cell cycle progression by a dual mechanism that involves downregulation of G1 cyclin expression and direct targeting of the CDK-inhibitor protein Sic1. The MAP

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26

Knockleby, James. "A role for the «Saccharomyces cerevisiae» kinetochore protein Ame1 in cell cycle control and MT-kinetochore attachment." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22031.

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High fidelity chromosome segregation in all cells requires the formation of bi-oriented attachments between spindle microtubules (MT) and chromosomes. The kinetochore provides a bridge between the MTs and chromosomes. Ame1 is an essential but undercharacterized component of the central kinetochore COMA sub-complex (Ctf19, Okp1, Mcm21, Ame1). In order to characterize Ame1, I used two conditional alleles of the COMA, ame1-4 and okp1-5. I examined the role of Ame1 in the context of the kinetochore and in the maintenance of the spindle assembly checkpoint (SAC) and the formation and repair of kine

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27

Pathak, Ritu. "Regulation of initiation of division in Saccharomyces cerevisiae: characterization of the role of DCR2, GID8, and KEM1 in completion of START." Texas A&M University, 2006. http://hdl.handle.net/1969.1/4819.

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The decision to initiate division is very important, as once cells have initiated division they are committed to complete it. In Saccharomyces cerevisiae, commitment to a new round of cell division occurs at a regulatory point in late G1 called START. Progression through START requires the activation of the cyclin dependent kinase Cdc28p by the G1 cyclins. G1 cyclins in complex with Cdc28p activate the transcription of approximately 100 genes involved in the G1 to S transition and degradation of Sic1p, an inhibitor of B type cyclins, and thus are important for initiation of DNA replication. De

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Dauban, Lise. "Organisation du génome par le complexe cohésine chez la levure Saccharomyces cerevisiae." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30100.

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La cohésine est un complexe protéique conservé dans l'évolution composé d'un anneau capable d'embrasser l'ADN et de protéines auxiliaires régulant son association avec l'ADN. D'une part, la cohésine confère la cohésion des chromatides sœurs nécessaire à leur ségrégation, d'autre part elle établit et maintient des boucles de chromatine. Ces boucles sont requises pour la formation de domaines topologiques, l'expression génique et la stabilité du génome. Cependant les mécanismes régissant leur formation ne sont pas entièrement élucidés. Selon le modèle d'extrusion de boucles, la cohésine capturer

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29

Eckert, Carrie Ann. "Implications and dynamics of pericentric cohesin association during mitosis in Saccharomyces cerevisiae /." Connect to full text via ProQuest. IP filtered, 2006.

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Thesis (Ph.D. in Molecular Biology) -- University of Colorado, 2006.<br>Typescript. Includes bibliographical references (leaves 126-147). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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30

TRIPODI, FARIDA. "Protein Kinase CK2: a major regulator of the G1/S transition in Saccharomyces cerevisiae." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/7478.

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Casein kinase 2 (CK2) is a ubiquitous, essential and highly conserved eukaryotic kinase. It phosphorylates more than 300 substrates, but its physiological role and regulation mechanism are still poorly understood (Meggio and Pinna, 2003). CK2 is traditionally considered to be a tetrameric enzyme, composed of two catalytic subunits and two regulatory subunits, which are encoded in yeast by CKA1 and CKA2 genes, CKB1 and CKB2 genes respectively. Deletion of regulatory subunits, or of either catalytic subunit gene alone has few phenotypic effects, but simultaneous disruption of both CKA1 and CKA2

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31

Bolte, Melanie. "Regulation of the anaphase promoting complex (APC-C) in the mitotic and meiotic cell cycle of Saccharomyces cerevisiae." Doctoral thesis, [S.l.] : [s.n.], 2004. http://webdoc.sub.gwdg.de/diss/2004/bolte/bolte.pdf.

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32

Semple, Jeffrey. "Characterization of the role of Orc6 in the cell cycle of the budding yeast Saccharomyces cerevisiae." Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/2969.

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The heterohexameric origin recognition complex (ORC) acts as a scaffold for the G1 phase assembly of pre-replicative complexes. Only the Orc1-5 subunits are required for origin binding in budding yeast, yet Orc6 is an essential protein for cell proliferation. In comparison to other eukaryotic Orc6 proteins, budding yeast Orc6 appears to be quite divergent. Two-hybrid analysis revealed that Orc6 only weakly interacts with other ORC subunits. In this assay Orc6 showed a strong ability to self-associate, although the significance of this dimerization or multimerization remains unclear.

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Peyran, Landry. "Rôle de l’activation de la GTPase Rho à la membrane plasmique sur la progression du cycle cellulaire chez Saccharomyces cerevisiae." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0184.

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Une prolifération cellulaire saine nécessite un ordre correct des événements du cycle cellulaire et la surveillance de ces événements par des points de contrôle qui retardent la progression du cycle cellulaire lorsque des problèmes surviennent. Cependant, les cellules peuvent contourner l'activation persistante des points de contrôle et poursuivre le cycle cellulaire malgré des défauts du nombre de chromosomes ou des dommages de l'ADN. Il est donc essentiel de comprendre comment les cellules contrôlent l'ordre des événements du cycle cellulaire, comment les points de contrôle surveillent ces é

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Pietruszka, Patrycja. "Role of Tem1 phosphorylation in the control of mitotic exit and spindle positioning." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON1T021.

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Dans la levure S. cerevisiae, la mitose nécessite le positionnement du fuseau mitotique le long de l’axe cellule mère-bourgeon (future cellule fille) afin d‘assurer une bonne ségrégation des chromosomes. Ce phénomène requiert le fonctionnement de deux mécanismes impliquant les protéines Kar9 et Dyn1. Durant la métaphase, Kar9 se positionne de manière asymétrique le long du fuseau mitotique, avec une accumulation notable sur les microtubules qui émanent de l’ancien « spindle pole body » (SPB; l’équivalent du centrosome dans les vertébrés), qui est normalement dirigé vers le bourgeon. Dans le ca

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35

Teufel, Lotte. "Cyclins and their roles in cell cycle progression, transcriptional regulation and osmostress adaptation in Saccharomyces cerevisiae. A transcriptome-wide and single cell approach." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21205.

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Der eukaryotische Zellzyklus ist ein streng regulierter Prozess, für dessen zeitlichen Ablauf unter anderem oszillierende Genexpression notwendig ist. Die Regulation und die zeitliche Koordination des Zellzyklus sind nach wie vor fundamentale Fragen der Zellbiologie. Spezifische Ereignisse, wie DNA Replikation und Zellkernteilung, können vier Zellzyklusphasen zugeordnet werden, welche durch Cyclin-abhängige Kinasen, Cycline und deren Inhibitoren reguliert werden. Während in Saccharomyces cerevisiae Cyclin-abhängige Kinasen (Cdc28, Pho85) über den gesamten Zellzyklus zu Verfügung stehen, wer

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36

Buchanan, Christina Diane. "Identification and characterization of a checkpoint triggered by delayed replication in S. cerevisiae /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/10253.

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Pope, Patricia A. "Investigation of Multiple Concerted Mechanisms Underlying Stimulus-induced G1 Arrest in Yeast: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/680.

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Progression through the cell cycle is tightly controlled, and the decision whether or not to enter a new cell cycle can be influenced by both internal and external cues. For budding yeast one such external cue is pheromone treatment, which can induce G1 arrest. Two distinct mechanisms are known to be involved in this arrest, one dependent on the arrest protein Far1 and one independent of Far1, but the exact mechanisms have remained enigmatic. The studies presented here further elucidate both of these mechanisms. We looked at two distinct aspects of the Far1-independent arrest mechanism. First,

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Pope, Patricia A. "Investigation of Multiple Concerted Mechanisms Underlying Stimulus-induced G1 Arrest in Yeast: A Dissertation." eScholarship@UMMS, 2006. http://escholarship.umassmed.edu/gsbs_diss/680.

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Progression through the cell cycle is tightly controlled, and the decision whether or not to enter a new cell cycle can be influenced by both internal and external cues. For budding yeast one such external cue is pheromone treatment, which can induce G1 arrest. Two distinct mechanisms are known to be involved in this arrest, one dependent on the arrest protein Far1 and one independent of Far1, but the exact mechanisms have remained enigmatic. The studies presented here further elucidate both of these mechanisms. We looked at two distinct aspects of the Far1-independent arrest mechanism. First,

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Bhaduri, Samyabrata. "Regulation of CDK1 Activity during the G1/S Transition in S. cerevisiae through Specific Cyclin-Substrate Docking: A Dissertation." eScholarship@UMMS, 2014. http://escholarship.umassmed.edu/gsbs_diss/871.

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Several cell cycle events require specific forms of the cyclin-CDK complexes. It has been known for some time that cyclins not only contribute by activating the CDK but also by choosing substrates and/or specifying the location of the CDK holoenzyme. There are several examples of B-type cyclins identifying certain peptide motifs in their specific substrates through a conserved region in their structure. Such interactions were not known for the G1 class of cyclins, which are instrumental in helping the cell decide whether or not to commit to a new cell cycle, a function that is non-redundant wi

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40

Lázari, Lucas Cardoso. "Modelagem do ciclo celular e influência dos lncRNAs em Saccharomyces cerevisiae expostas a altas concentrações de etanol." Botucatu, 2020. http://hdl.handle.net/11449/192925.

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Orientador: Guilherme Targino Valente<br>Resumo: A intensa utilização de combustíveis fósseis gerapreocupações constantes devido aos impactos de sua combustão ao meio ambiente. Os biocombustíveis são uma alternativa viável aos combustíveis fósseis por apresentarem vantagens como serem menos agressivos ao meio ambiente. O bioetanol é um dos biocombustíveis mais utilizados no mundo e sua produção pode ser feita pela fermentação realizada pela levedura Saccharomyces cerevisiae. No entanto, altas concentrações de etanol inibem diversos mecanismos biológicos da levedura, causando a diminuição da pr

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Rai, Urvashi. "Spindle Assembly Checkpoint Stability Depends on Integrity of the Nucleolus and Septins in Saccharomyces cerevisiae." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1491568383512984.

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Parsons, Michelle L. "The Role of SIR4 in the Establishment of Heterochromatin in the Budding Yeast Saccharomyces cerevisiae." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31028.

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Heterochromatin in the budding yeast Saccharomyces cerevisiae is composed of polymers of the SIR (Silent Information Regulator) complex bound to nucleosomal DNA. Assembly of heterochromatin requires all three proteins of the Sir complex: the histone deacetylase Sir2, and histone binding proteins Sir3 and Sir4. Heterochromatin establishment requires passage through at least one cell cycle, but is not dependent on replication. Inhibition of chromatin modifying enzymes may be a mechanism for how cells limit assembly. Dot1 dependent methylation of H3K79 is suggested to inhibit de novo assembly. Ha

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Deniz, Ozgen. "Nucleosome Positioning in Budding Yeast = Posicionamiento de nucleosomas en Saccharomyces cerevisiae." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/145763.

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The nucleosome is the fundamental structural unit of DNA compaction in eukaryotic cells and is formed by the wrapping of 147 bp double stranded DNA around a histone octamer. Nucleosome organization plays a major role in controlling DNA accessibility to regulatory proteins, hence affecting cellular processes such as transcription, DNA replication and repair. Our study focuses on genome-wide nucleosome positioning in S. cerevisiae to explore nucleosome determinants and plasticity throughout the cell cycle and their interplay with gene expression based on cell mRNA abundance. We pursued t

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Pessoa-Brandão, Luis. "Genetic and molecular studies of Saccharomyces cerevisiae Cdc7-Dbf4 kinase function in DNA damage-induced mutagenesis /." Connect to full text via ProQuest. IP filtered, 2005.

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45

GOTTI, LAURA. "Nutritional modulation of cell size at s phase initiation in the buddine yeast saccharomyces cerevisiae: a role for glucose sensing and the cyclin dependent kinase inhibitor." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/19573.

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The budding yeast Saccharomyces cerevisiae is a model organism for studies on cell cycle. For the survival of this cells a tight coordination of cell growth and division occurs at Start, a regulatory area of the cell cycle positioned immediately before beginning of S phase, at the G1-S boundary. Start is the event, or set of events, that commits a cell to a round of division. This mechanism is based on achieving of a critical cell size (protein content per cell at the onset of DNA replication, Ps) to enter into S phase. Ps increases in proportion with ploidy and is modulated by nutrients. In

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Charton, Romain. "Étude du comportement de la chromatine, de la régulation de la transcription et réparation des gènes de l’ARNr avant la réplication de l’ADN et assemblage de la réparation par excision de nucléotides chez Saccharomyces cerevisiae." Thèse, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/9527.

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Résumé : Le nucléole est considéré comme étant une « usine » à produire des ribosomes. Cette production est la fonction la plus énergivore de la cellule. Elle met en jeu les trois ARN polymérases et représente 80% de l’activité de transcription au sein d’une cellule. Les trois quarts de cette activité de transcription correspondent à la synthèse des ARNr par l’ARN polymérase I (ARNPI). Ainsi mieux comprendre les mécanismes cellulaires se déroulant à l’intérieur de ce compartiment permettra le développement de nouveaux traitements contre le cancer. La synthèse d’ARNr par l’ARNPI est régulée à t

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Müller, Dirk [Verfasser]. "Model-Assisted Analysis of Cyclic AMP Signal Transduction in Saccharomyces cerevisiae – cAMP as Dynamic Coordinator of Energy Metabolism and Cell Cycle Progression / Dirk Müller." Aachen : Shaker, 2006. http://d-nb.info/1170528538/34.

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Adkins, Melissa Wess. "The role of histone chaperones in chromatin structure and gene expression /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2006.

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Thesis (Ph.D. in Biochemistry & Molecular Genetics) -- University of Colorado at Denver and Health Sciences Center, 2006.<br>Typescript. Includes bibliographical references (leaves 147-164). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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Flaman, Jean-Michel. "La levure Saccharomyces cerevisiae : un modèle pour l'étude de l'activité transcriptionnelle de p53 et de son altération dans les cancers." Rouen, 1997. http://www.theses.fr/1997ROUES084.

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Les mutations du gène suppresseur de tumeur p53 représentent l'anomalie moléculaire la plus fréquemment observée dans les cancers suggérant que l'inactivation de ce gène constitue une étape clé de la transformation maligne. Le gène p53 code pour un facteur de transcription capable, en réponse à des conditions génotoxiques, de réguler l'expression des gènes p21 et Bax respectivement impliquées dans l'arrêt du cycle cellulaire et l'activation de l'apoptose. Les données à la fois structurales et fonctionnelles suggèrent que la conséquence majeure des mutations du gène p53 dans les cancers est la

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Dražková, Jana. "Emergentní vlastnosti sítě G1/S." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2010. http://www.nusl.cz/ntk/nusl-229035.

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Tato práce se zabývá buněčným cyklem kvasinky Saccgaromyces cerevisiae. Oblastí našeho zájmu je přechod mezi G1 a S fází, kde je naším cílem identifikovat velikosti buňky v době počátku DNA replikace. Nejprve se věnujeme nedávno publikovanému matematickému modelu, který popisuje mechanismy vedoucí k S fázi. Práce poskytuje detailní popis tohoto modelu, stejně jako časový průběh některých důležitých proteinů či jejich sloučenin. Dále se zabýváme pravděpodobnostním modelem aktivace replikačních počátků DNA. Nově uvažujeme vliv šíření DNA replikace mezi sousedícími počátky a analyzujeme jeho důsl

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