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Academic literature on the topic 'Saccharide derivatives'

Author: Grafiati

Published: 10 March 2023

Last updated: 11 March 2023

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Journal articles on the topic "Saccharide derivatives"

1

Fujishima, Masaki, Kensuke Furuyama, Yojiro Ishihiro, Shuichi Onodera, Eri Fukushi, Noureddine Benkeblia, and Norio Shiomi. "Isolation and Structural Analysis In Vivo of Newly Synthesized Fructooligosaccharides in Onion Bulbs Tissues (Allium cepa L.) during Storage." International Journal of Carbohydrate Chemistry 2009 (June 18, 2009): 1–9. http://dx.doi.org/10.1155/2009/493737.

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Fructooligosaccharides are involved in physiological activities and quality attributes of onion bulbs. This work describes structures of newly synthesized oligosaccharides formed by fructose moieties in onion bulb tissues during storage. Onion bulbs were stored for four weeks at 10. HPAEC-PAD analysis showed that saccharide 1 was eluted after 1-kestose while saccharide 2 was eluted after nystose . Saccharides 1 and 2 have R-sucrose values of 1.55 and 2.15 by HPAEC, a reducing terminal, a reducing sugar-to-fructose ratio of 0.5 and 0.3, and a degree of polymerization of 2 and 3 by TOF-MS, respectively. GLC analysis of the methyl derivatives and NMR measurement of the saccharides confirmed the presence of two different structures: the structure of saccharide 1 is composed by two fructose moieties and linked by linkage and was identified as inulobiose [-D-fructofuranosyl---D-fructopyranose]. The structure of saccharide 2 consists of three units of fructose linked by linkage and was identified as inulotriose [-D-fructofuranosyl---D-fructofuranosyl---D-fructopyranose]. The spectra also showed that 70 to 80% of the terminal fructose residue of the two saccharides is of pyranosyl form, while 20 to 30% is of furanosyl form. This finding demonstrated that these newly produced saccharides, catalyzed by onion-purified 6G-FFT, were synthesized by the action of 1-FFT fructosyltransfer from 1-kestose to free fructopyranose yielding inulobiose and sucrose, while elongation of fructofuranosyl units occurs at this transferred fructofuranosyl residue to produce inulooligosaccharide having an additional unit of fructofuranose.

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2

Hung, Wei-Ting, Yi-Ting Chen, Chung-Hsuan Chen, Yuan Chuan Lee, Jim-Min Fang, and Wen-Bin Yang. "Flow Chemistry System for Carbohydrate Analysis by Rapid Labeling of Saccharides after Glycan Hydrolysis." SLAS TECHNOLOGY: Translating Life Sciences Innovation 25, no. 4 (June 19, 2020): 356–66. http://dx.doi.org/10.1177/2472630320924620.

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This study demonstrates the utilization of a flow chemistry system for continuous glycan hydrolysis and saccharide labeling to assist with the existing methods in glycan structural analysis. Acidic hydrolysis of glycans could be accelerated in a flow system. Aldoses and α-ketoacid-type saccharides were effectively labeled with naphthalene-2,3-diamine (NADA) at 60 °C for 10 min to form the fluorescent naphthimidazole (NAIM) and quinoxalinone (QXO) derivatives, respectively. The NADA-labeled derivatives improved the structural determination and composition analysis for their parent saccharides by using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), liquid chromatography mass spectrometry (LC-MS), and nuclear magnetic resonance (NMR). Furthermore, this protocol was applied to determine the SA–Gal–Glc sequence of GM3-sugar out of six possible permutations.

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3

İ MAHMOOD, Israa, Salih SALMAN, and Luma ABD. "New Bioactive Aromatic Heterocyclic Macromolecules with Monosaccharide Core." Journal of the Turkish Chemical Society Section A: Chemistry 9, no. 3 (August 31, 2022): 889–900. http://dx.doi.org/10.18596/jotcsa.1098055.

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1,1,2-trimethyl-1H-benzo[e]indole is an important heterocyclic compound, its available in reasonable price and can easily modified to make a good intermediate for other derivatives. That is quite enough reasons to use as starting material for a new series of compounds with other biomolecules such as monosaccharides after simple modification. The target molecules show biological activity. So, the current work is aiming to improve the activity and the properties of the benzo indole by attaching with a naturally occurring, and biodegradable compounds represented by 2-deoxy-2-amino -d-glucose and 6-deoxy-6-amino-d-glucose to synthesis both mono and di-saccharides derivatives of benzo indole. Two steps synthesis were used for mono-saccharide derivatives and three steps for di-saccharide derivatives, the first is the functionalization of 1,1,2-trimethyl-1H-benzo[e]indole [1] via the reaction with POCl3 to produce 2-(1,1-dimethyl-1H-benzo[e]indol-2(3H)-ylidene) malonaldehyde [2] with two aldehydes reaction centers, while in the second step the latter was coupled with sugar via amino groups to get the two monosaccharide derivatives [3,5], while the disaccharides molecules [4,6] taken one more step with harder conditions to overcome the steric hindrance at the other reaction center. The purity and characterization of the target molecules was confirmed using spectroscopy methods including 1H NMR and 13 NMR. The synthesized compound shows a good biological activity as antibacterial antifungal.

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4

Yuan, Dan, Xuewen Du, Junfeng Shi, Ning Zhou, Abdulgader Ahmed Baoum, and Bing Xu. "Synthesis of novel conjugates of a saccharide, amino acids, nucleobase and the evaluation of their cell compatibility." Beilstein Journal of Organic Chemistry 10 (October 16, 2014): 2406–13. http://dx.doi.org/10.3762/bjoc.10.250.

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This article reports the synthesis of a novel type of conjugate of three fundamental biological build blocks (i.e., saccharide, amino acids, and nucleobase) and their cell compatibility. The facile synthesis starts with the synthesis of nucleobase and saccharide derivatives, then uses solid-phase peptide synthesis (SPPS) to build the peptide segment (Phe-Arg-Gly-Asp or naphthAla-Phe-Arg-Gly-Asp with fully protected groups), and later, an amidation reaction in liquid phase connects these three parts together. The overall yield of these multiple step synthesis is about 34%. Besides exhibiting excellent solubility, these conjugates of saccharide–amino acids–nucleobase (SAN), like the previously reported conjugates of nucleobase–amino acids–saccharide (NAS) and nucleobase–saccharide–amino acids (NSA), are mammalian cell compatible.

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5

Klein, J., M. Kraus, M. Tich�, B. Zelezn�, V. Jon�kov�, and J. Kocourek. "Water-soluble poly(acrylamide-allylamine) derivatives of saccharides for protein-saccharide binding studies." Glycoconjugate Journal 12, no. 1 (February 1995): 51–54. http://dx.doi.org/10.1007/bf00731868.

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6

Ćwik, Paweł, Patrycja Ciosek-Skibińska, Marcin Zabadaj, Sergiusz Luliński, Krzysztof Durka, and Wojciech Wróblewski. "Differential Sensing of Saccharides Based on an Array of Fluorinated Benzosiloxaborole Receptors." Sensors 20, no. 12 (June 22, 2020): 3540. http://dx.doi.org/10.3390/s20123540.

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Fluorinated benzosiloxaboroles–silicon congeners of benzoxaboroles, were synthesized and tested as molecular receptors for mono- and disaccharides. The receptors differed in the Lewis acidity of the boron center as well as in the number of potential binding sites. The calculated stability constants indicated different binding affinity of benzosiloxaborole derivatives towards selected saccharides, enabling their classification using a receptor array-based sensing. Unique fluorescence fingerprints were created on the basis of competitive interactions of the studied receptors with both Alizarin Red S (ARS) and tested saccharide molecules. Detailed chemometric analysis of the obtained fluorescence data (based on partial least squares-discriminant analysis and hierarchical clustering analysis) provided the differential sensing of common saccharides, in particular the differentiation between glucose and fructose. In addition, DFT calculations were carried out to shed light on the binding mechanism under different pH conditions.

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7

Bashir, Sajid, Peter J. Derrick, Peter Critchley, Paul J. Gates, and James Staunton. "Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry of Dextran and Dextrin Derivatives." European Journal of Mass Spectrometry 9, no. 1 (February 2003): 61–70. http://dx.doi.org/10.1255/ejms.510.

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Application of matrix-assisted laser desorption/ionization (MALDI) to the analysis of dextran and dextrin derivatives, specifically glucose saccharides, by time-of-flight (TOF) mass spectrometry is reported. MALDI-TOF analysis was carried out on alpha-, beta-and gamma-cyclodextrin, two O-methylated beta-cyclodextrins of differing degrees of substitution (DS) and dextrans (a linear glucose saccharide), as pure and doped solutions and as mixtures of two or more of these analytes. Doping was carried out with trace amounts of inorganic salts. The purpose of the analysis of the cyclodextrins was to determine whether they would form inclusion complexes with the various added cations, or whether less specific cation addition/exchange was occurring either prior to desorption or in the gas phase.

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8

McGregor, Nicholas, Christophe Pardin, and W. G. Skene. "Using Quenching Kinetics and Thermodynamics of Amino-Fluorophores as Empirical Tools for Predicting Boronic Acid Sensors Suitable for Use in Physiological Conditions." Australian Journal of Chemistry 64, no. 11 (2011): 1438. http://dx.doi.org/10.1071/ch11297.

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A series of water-soluble 1-amino-naphthalenes and 2-amino-fluorenes are prepared. These serve as model fluorophores for measuring the thermodynamics and kinetics of fluorescence quenching with phenylboronic acids and aliphatic amines. Steady-state and time-resolved fluorescence quenching kinetics are investigated using the Stern–Volmer method. Diffusion limited quenching constants and exergonic thermodynamics of electron transfer are derived for the 5-amino-1-napthol and 2-aminofluorene derivatives with phenylboronic acid and/or an aliphatic imine. No quenching and endergonic thermodynamics or electron transfer are observed for 5-sulfonamide, 5-sulfonic acid, or 5-hydroxy-7-sulfonic acid aminonaphthalene derivatives. Boronic acid sensors synthesized from these aminofluorophores by reductive amination with 2-formylphenylboronic acid undergo fluorescence revival in the presence of saccharides only when the fluorophore demonstrates diffusion limited quenching kinetics and exergonic thermodynamics of electron transfer with the boronic acid or imine quenchers. Thus, these two properties are suitable empirical tools for predicting saccharide-induced fluorescence revival of boronic acid sensors.

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9

Jackson, P. "The use of polyacrylamide-gel electrophoresis for the high-resolution separation of reducing saccharides labelled with the fluorophore 8-aminonaphthalene-1,3,6-trisulphonic acid. Detection of picomolar quantities by an imaging system based on a cooled charge-coupled device." Biochemical Journal 270, no. 3 (September 15, 1990): 705–13. http://dx.doi.org/10.1042/bj2700705.

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Various monosaccharides, oligosaccharides and small polysaccharides were labelled covalently at their reducing end groups with the fluorophore 8-aminonaphthalene-1,3,6-trisulphonic acid (ANTS), and the resulting fluorescent derivatives were separated by high-resolution PAGE. The electrophoretic mobilities of the labelled saccharides are related largely to the compounds' Mr values, but they are also influenced by the individual chemical structures of the saccharides. Various positional isomers and some epimers, for instance galactose and glucose, were resolved. Oligosaccharide and small polysaccharide derivatives, prepared from an enzymic digest of starch, each differing in size by a single hexose residue and with a range of degrees of polymerization from 2 to 26, were all resolved in a single gel. The method was relatively rapid and simple to perform. It enabled multiple samples to be analysed in parallel with high sensitivity. The fluorescent-labelling procedure was virtually quantitative. As little as 1 pmol of ANTS-labelled saccharide was detected photographically when the gels were illuminated by u.v. light. When the gels were viewed using an imaging system based on a cooled charge-coupled device, as little as 0.2 pmol was detected. The method may be useful for the structural analysis of the carbohydrate moieties of glycoconjugates and other naturally occurring oligosaccharides.

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10

Menuel, S., B. Léger, A. Addad, E. Monflier, and F. Hapiot. "Cyclodextrins as effective additives in AuNP-catalyzed reduction of nitrobenzene derivatives in a ball-mill." Green Chemistry 18, no. 20 (2016): 5500–5509. http://dx.doi.org/10.1039/c6gc00770h.

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At the boundary between mechanochemistry, supramolecular chemistry and catalysis, the present study explores the role of cyclodextrins (CDs) and other saccharide additives in the mechanosynthesis of gold nanoparticles (AuNPs) and their use as catalysts in the reduction of substituted nitrobenzene derivatives.

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Dissertations / Theses on the topic "Saccharide derivatives"

1

Derbyshire, Helen M. "Physical properties of hydrated saccharides and saccharide derivatives." Thesis, De Montfort University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391851.

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2

Broberg, Karl Rufus. "Synthetic approaches towards heparinoid related saccharides and derivatives." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/synthetic-approaches-towards-heparinoid-related-saccharides-and-derivatives(6c1366ba-82dc-43b2-9af3-294ebed56639).html.

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Heparin glycosaminoglycans mediate a range of biological events, including anticoagulation as well as a diversity of cell proliferation and differentiation processes. Heparin saccharides have been shown to act as inhibitors against angiogenesis and metastasis of tumour cells. This thesis describes work developing chemistry towards varying length oligosaccharide sequences with potential to offer variable sulfation patterns. The main synthetic components to this work were contribution to developing scalable syntheses of an orthogonally protected L-Iduronic acid unit and a differentially protected D-glucosamine unit. The synthetic work also evaluated a recently reported diazo transfer reagent, which allowed for earlier placement of azide protection over that of previously developed routes within the group. This provided a cheaper, more atom efficient route towards protected D-glucosamine building blocks. Glycosylation of the developed D-GlcN donor units with the L-Ido acceptor allowed the production of key disaccharides which facilitated an efficient iterative glycosylation strategy towards longer oligosaccharides, ultimately providing a differentially protected pentasaccharide. The project evaluated methods towards generating various dimeric heparin type systems through forming new O4 ether linkages between GlcN residues across various short linker fragments. The most successful of these dimerisations used a methallyl dichloride core which allowed for further derivatisation towards dihydroxylated species, the analysis of which highlighted some interesting proton NMR data. The final aspect of this project began development of chemistry towards non-reducing end-labelled oligosaccharide sequences by implementation of a masked aldehyde unit on the C4 hydroxyl of GlcN synthesised from the allylated GlcN precursor via dihydroxylation chemistry. Incorporation of this moiety (protected as a 1,2-dibenzyl glycol) within both a trisaccharide and a pentasaccharide was achieved. Further development of this chemistry should allow for late step oxidative cleavage to reveal the reactive aldehyde, potentially allowing for attachment of various amine functionalised fluorophores via reductive amination. Radiolabelling of such a species should also be possible through sodium borotritide reduction for example.

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3

Manning, David D. "Selectin-saccharide interactions of monovalent and multivalent carbohydrate derivatives." 1997. http://catalog.hathitrust.org/api/volumes/oclc/37136928.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1997.
Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leavs 284-302).

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4

PAPACCHINI, ALESSANDRA. "Synthesis, characterization and applicative study of innovative materials for the conservation of cellulosic artifacts with an artistic and architectural interest." Doctoral thesis, 2017. http://hdl.handle.net/2158/1076288.

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Synthesis of new monomers from renewable resources (saccharides) and their use in the synthesis of copolymers with vinyl acetate. Hydrolysis of the vinyl acetate copolymers to vinyl alcohol copolymers. Preparation of nanocomposites between TiO2 nanoparticles and vinyl acetate copolymers. Characterization of all new products using different techniques (FT-IR and NMR spectroscopy, SEM, SEC, DSC). Applicative studies to test the applicability of the new products to the conservation of cellulosic materials (wood, paper) in the field of cultural heritage: test on the consolidation of archaeological waterlogged wood using the vinyl alcohol copolymer; test on the antimicotic effect of the nanocomposite TiO2/vinyl acetate copolymer on recent wood; colorimetric test on paper treated with the vinyl alcohol copolymers.

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5

Jian, Chong-Shun, and 簡崇訓. "Study of Glycyrrhizic Acid and Azasugars:Synthesis of Glycyrrhizic Acid Derivatives as the Anti-SARS-CoV AgentsSynthesis of Azasugars and the Reactions of Saccharides in Aqueous Solution." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/75805997766943197618.

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碩士
國立臺灣大學
化學研究所
93
This thesis consists of two parts. In the first part, we already synthesize glycyrrhizic acid derivatives as the antiviral angents against severe acute respiratory syndrome corona virus (SARS–CoV) agents. In the second part, we synthesize azasugars and explore some reactions of saccharides in I2/NH3 aqueous solution. Glycyrrhizic acid is known to exhibit wide range of biological activities, for example, anti–inflammatory, anti–allergic, anti–dote, antioxidation and anti–tumor activities. However, the mechanism of glycyrrhizic acid in vivo is still unclear. It is reported that glycyrrhizic acid has the activity to inhibit the replication of the SARS coronavirus,but the inhibition concentration is still high. Consequently, it is desirable to find better SARS–CoV inhibitors by modification of glycyrrhizic acid. The structure of glycyrrhizic acid consists of two parts, one is 18β glycyrrhetinic acid and the other is disaccharide. I carried out a research work to replace the disaccharide part by other important saccharides, e. g., sialic acid and GlcNAc, to obtain compounds 25 and 26. By comparision of the inhibitory activity of glycyrrhizic acid (EC50 =1mM), we found that compound 25 greatly improves the inhibitory activity (EC50 = 20 μM) against the infection of SARS coronavirus on Vero E6 cells. Antibiotic resistance is a serious problem in many diseases. transglycosydase is one of enzyme in essential of bacterial cell wall synthesis. We desire to synthesize azasugars as transglycosydase inhibitors. In this part, we have synthesized the backbone structure of azasugars. In another approach, we found GlcNAc was degraded by I2 and ammonia water. We also found that saccharides can be linked with primary amines in aqueous solution by the promotion of I2. This novel type reaction is potentially useful in carbohydrate chemistry, such as in preparation of glycopetide in future.

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GUGLIELMI, PAOLO. "Synthesis and biological evaluation of new saccharin-based inhibitors of cancer-related carbonic anhydrase IX and XII isoforms & Benzo[b]tiophen-3-ol derivatives as effective inhibitors of hMAOs: design, synthesis and biological activity." Doctoral thesis, 2018. http://hdl.handle.net/11573/1213367.

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Synthesis and biological evaluation of new saccharin-based inhibitors of cancer-related carbonic anhydrase IX and XII isoforms Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread metalloenzymes implicated in many cellular and physiological processes requiring bicarbonate as substrate (e.g. electrolyte secretion, pH homoeostasis, respiration etc.). The fifteen human isoforms of carbonic anhydrase (hCAs) differ in cellular localization (cytosol, mitochondria or cell membrane), sensibility to inhibitors and catalytic activity. hCAs are well established therapeutic targets to treat a wide range of disorders. In particular, hCA IX and XII have been recognized as tumor-related isoforms, participating in the complex machinery which regulate the pH of cells in hypoxic tumors. In our previously reported studies we showed that N-alkylated saccharin derivatives effectively inhibited the two cancer-related isoforms. Here we report the design, synthesis and the inhibitory activity of novel compounds based on saccharin scaffold. We used two different approaches in order to obtain two series of new compounds. In the first approach, we performed a reductive ring opening of N-alkylated saccharin derivatives, obtaining molecules endowed with secondary sulfonamide and primary alcohol. In the second approach, a series of tertiary sulfonamides (saccharin/isoxazole and saccharin/isoxazoline derivatives) were obtained by the insertion of isoxazole or isoxazoline moiety as spacer between the saccharin nitrogen and (un)substituted aryl or heteroaryl rings. All the synthesized compounds were tested to evaluate their inhibitory activity towards the ubiquitous off-target isoforms, hCA I and II, and the cancer-related ones, hCA IX and XII, by a stopped-flow, CO2 hydrase assay. All the compounds were inactive against the two cytosolic off-target hCA I and II (Kis > 10 µM), while showed inhibitory activity in the low nanomolar range against the two cancer-related isoforms hCA IX and XII. Computational approach has been performed in order to better understand the binding mode of these inhibitors. Benzo[b]tiophen-3-ol derivatives as effective inhibitors of hMAOs: design, synthesis and biological activity Monoamine oxidases (MAOs; EC 1.4.3.4) are mitochondrial bound flavoenzymes, which catalyse the oxidative degradation of amines. They have been widely recognised as important pharmacological targets for the treatment of mood disorders (anxiety, depression) and neurodegeneration (Parkinson’s disease, PD) as the result of their effects on monoamine metabolism and level. Furthermore, evidences show the probable implication of these enzymes in some tumors (e.g prostatic cancer) and cardiomyopathies. Based on tissue localization, structural homology, active site differences, substrate/inhibitor selectivity and catalytic efficiency, two isoforms have been characterized (MAO-A and MAO-B). Both of them could be the target of selective inhibitors acting as reversible or irreversible agents. An extensive number of natural and synthetic compounds have shown effective inhibition of human MAOs. Indole analogues, aurones and indanone derivatives are examples of MAO inhibitors. They show a common structural feature that is the chalcone moiety, whose ability to bind hMAO enzymes has been reported by our research group. With the aim to expand our knowledge about hMAO inhibtion, we performed the design, synthesis, characterization and in vitro biological activity evaluation of some novel benzo[b]thiophen-3-ol derivatives. This scaffold retained the above cited chalcone system, differing from the already studied inhibitors in some features like the isosteric replacement of aurones’ oxygen with sulphur one, the presence of 1,3-diketone system giving keto-enol tautomerism and the presence of a carbonyl group instead of methylylidene one, bound at position 2 of the bicyclic system. These compounds have been synthesised through a new simple synthetic approach consisting in a one-step reaction, which led to moderate to high yields. The obtained compounds showed activity in the micromolar/low micromolar range against hMAO-B with the best inhibition profile observed for compounds containing phenyl ring substituted in the meta- position with halogens. These compounds have also been tested with cortex synaptosomes in both basal and LPS-induced inflammatory conditions to evaluate their ability to affect the DOPAC/DA ratio as well as LDH activity. DOPAC/DA ratio is an indirect index of MAO-B activity, and all the tested compounds are effective in reducing this value in cortex synaptosomes challenged with LPS, showing outcomes better than the reference drug deprenyl. Furthermore, all the tested molecules inhibited LDH activity in the concentration range 0.1-1 µM, showing potential activity as neuroprotective agents.

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Books on the topic "Saccharide derivatives"

1

Derbyshire, Helen M. Physical properties of hydrated saccharides and saccharide derivatives. Leicester: De Montfort University, 2000.

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2

Royal Society of Chemistry (Great Britain), ed. Mono-, di-, and tri-saccharides and their derivatives: A review of the literature published during 1984. London: The Royal Society of Chemistry, 1986.

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E, Davison B., Ferrier R. J, and Furneaux R. H, eds. Carbohydrate chemistry: A review of the literature published during 1983 : Mono-, di-, and tri-saccharides and their derivatives. London: Royal society of chemistry, 1985.

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Williams, N. R. Carbohydrate Chemistry: Mono-, Di-, and Tri-Saccharides and Their Derivatives (Carbohydrate Chemistry). Royal Society of Chemistry, 1985.

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5

Sainsbury, Malcolm. Aliphatic Compounds: Trihydric Alcohols, Their Oxidation Products and Derivatives, Penta- and Higher Polyhydric Alcohols, Their Oxidation Products and Derivatives; Saccharides, Tetrahydric Alcohols, Their Oxidation Products and Derivatives. Elsevier, 2016.

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Coffey, S. Penta- and Higher Polyhydric Alcohols, Their Oxidation Products and Derivatives, Saccharides: A Modern Comprehensive Treatise. Elsevier, 2013.

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Coffey, S. Aliphatic Compounds : Penta- and Higher Polyhydric Alcohols; Their Oxidation Products and Derivatives; Saccharides: A Modern Comprehensive Treatise. Elsevier, 2016.

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Book chapters on the topic "Saccharide derivatives"

1

Kassab, Rima, and Helene Parrot-Lopez. "Synthesis of Cyclodextrins Derivatives Carrying Bio-Recognisable Saccharide Antennae." In Molecular Recognition and Inclusion, 381–84. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5288-4_64.

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2

Assempour, Homa, M. F. Koenig, and S. J. Huang. "Synthesis and Characterization of Dodecenyl Succinate Derivatives of Saccharides." In ACS Symposium Series, 69–81. Washington, DC: American Chemical Society, 1994. http://dx.doi.org/10.1021/bk-1994-0575.ch004.

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Kotora, Martin. "Carboranyl-saccharide Derivatives: Syntheses and Biological Evaluation." In Handbook of Boron Science, 69–99. WORLD SCIENTIFIC (EUROPE), 2018. http://dx.doi.org/10.1142/9781786344670_0004.

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4

Coppens, Michiel. "Fondaparinux and its derivatives." In ESC CardioMed, edited by Raffaele DeCaterina, 253–55. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0051.

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Fondaparinux is a pentasaccharide and consists of the five saccharides by which heparin and low-molecular weight heparins bind to and potentiate antithrombin. It is used as an alternative to low-molecular weight heparin in patients with acute coronary syndromes without persistent ST-segment elevation, and in patients with acute coronary syndromes with persistent ST-segment elevation who do not undergo reperfusion therapy or fibrinolytic therapy. For this indication, fondaparinux reduced the risk of major bleeding by 30% and the risk of death by 10% without an excess in thrombotic complications. Other approved indications are treatment of superficial vein thrombosis and prevention of venous thromboembolism after hip or knee arthroplasty, after abdominal surgery, and in acutely ill medical patients. Furthermore, fondaparinux is approved for the initial therapy in acute venous thromboembolism, although it is rarely used for this indication. Finally, fondaparinux is pathophysiologically attractive for the treatment of patients with heparin-induced thrombocytopenia and case series confirm its efficacy and safety although regulatory approval was never sought. Idraparinux and idrabiotaparinux are pentasaccharides with longer elimination half-lives than fondaparinux, allowing once-weekly dosing. Development of these drugs was halted because of an excess of bleeding (idraparinux) and commercial reasons (idrabiotaparinux).

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Taber, Douglass F. "Preparation of Benzene Derivatives: The Yu/Baran Synthesis of (+)-Hongoquercin A." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0061.

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Lutz Ackermann of the Georg-August-Universität Göttingen oxidized (Org. Lett. 2013, 15, 3484) the anisole derivative 1 to the phenol 2. Melanie S. Sanford of the University of Michigan devised (Org. Lett. 2013, 15, 5428) complementary conditions for either para acetoxylation of 3, illustrated, to give 4, or meta acetoxylation. Lukas J. Goossen of the Technische Universität Kaiserlautern developed (Synthesis 2013, 45, 2387) conditions for the cascade alkoxylation/decarboxylation of 5 to give 6. Cheol-Hong Cheon of Korea University showed (J. Org. Chem. 2013, 78, 12154) that the boronic acid of 7 could act as a blocking group during electrophilic aromatic substitution or, as illustrated, as an ortho directing group. It could then be removed by protodeboronation, leading to 8. Jun Wu of Zhejiang University coupled (Synlett 2013, 24, 1448) the phenol 9 with the bromo amide 10 to give an ether that, on exposure to KOH at elevated temperature, rearranged to the intermediate amide, that was then hydrolyzed to 11. Dong-Shoo Shin of Changwon National University reported (Tetrahedron Lett. 2013, 54, 5151) a similar protocol (not illustrated) to prepare unsubstituted anilines. Guangbin Dong of the University of Texas, Austin used (J. Am. Chem. Soc. 2013, 135, 18350) a variation on the Catellani reaction to add 13 to the ortho bromide 12 to give the meta amine 14. Kei Manabe of the University of Shizuoka found (Angew. Chem. Int. Ed. 2013, 52, 8611) that the crystalline N-formyl saccharin 16 was a suitable CO donor for the carbonylation of the bromide 15 to the aldehyde 17. John F. Hartwig of the University of California, Berkeley described (J. Org. Chem. 2013, 78, 8250) the coupling of the zinc enolate of an ester (Reformatsky reagent), either preformed or generated in situ, with an aryl bromide 18 to give 19. Olafs Daugulis of the University of Houston developed (Org. Lett. 2013, 15, 5842) conditions for the directed ortho phenoxylation of 20 with 21 to give 22. Yao Fu of the University of Science and Technology of China effected (J. Am. Chem. Soc. 2013, 135, 10630) directed ortho cyanation of 23 with 24 to give 25.

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Conference papers on the topic "Saccharide derivatives"

1

Gabrovšek, Ana, Nika Tašler, Rigoberto Barrios-Francisco, and Marko Jeran. "Impact of a Saccharin Higher Homolog on Saccharomyces cerevisiae." In Socratic Lectures 7. University of Lubljana Press, 2022. http://dx.doi.org/10.55295/psl.2022.d15.

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Saccharin is an organic compound, which is often used as a calorie-free artificial sweetener. It salts are being produced for the market for over 80 years. Saccharin and its derivates are very applicatory oriented, therefore researchers synthesize more and more active ingredients, which could potentially show better performance. This work considers the effect of biological activity of a newly synthesized saccharin derivative Me- thyl 4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-3-carboxylate (6Sac) on yeast Saccharomyces cere-visiae. Qualitative comparison of the studied activity with the activity of the saccharine sodium salt is presented. Our results were gained by two different ways of viability detection: counting dead/live cells dyed with methylene blue and counting colony-forming units (CFU). The study has shown that the saccharine derivative with an ester functional group has negative effect on growth and repro-duction of yeast. The qualitative comparison of the activity of the tested substance with the already known activity of saccharine sodium salt is a convenient method for following the model organism Saccharomyces cerevisiae. Keywords: Saccharin, sodium saccharinate, Saccharomyces cerevisiae, Viability, Methylene blue, Col-ony-forming units (CFU), Medicine

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2

Costantino, Andrea, Sandra Mandolesi, and Liliana Koll. "Michael Addition of Phthalimide and Saccharin to Enantiomerically Pure Diesters of BINOL and TADDOLs Derivatives Under Microwave Conditions." In The 18th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-c012.

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