Dissertations / Theses on the topic 'S-PEG'
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Maria, Roberta Patr?cia Medeiros de. "S?ntese e caracteriza??o el?trica de blendas e comp?sitos de PMMA/PEG e PMMA/PEG/Na2WO4.2H2O." PROGRAMA DE P?S-GRADUA??O EM QU?MICA, 2015. https://repositorio.ufrn.br/jspui/handle/123456789/22692.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES)
? medida que demandas energ?ticas foram sendo apresentadas e requeridas pelo avan?o tecnol?gico, a s?ntese de novos materiais, capazes de suprir estas necessidades, foi e tem sido exaustivamente executada e estudada; dentre estes materiais, est?o filmes polim?ricos comp?sitos que t?m se destacado como uma alternativa qu?mica, f?sica, el?trica e econ?mica vi?vel. Neste trabalho filmes finos autossustent?veis de poli(metactrilato de metila) (PMMA) sob a forma de blendas, associado ao poli(etileno glicol) (PEG), e comp?sitos, dopados com tungstato de s?dio diidratado, foram obtidos pela associa??o dos m?todos sol-gel e ?casting?. A caracteriza??o el?trica, estrutural, qu?mica e morfol?gica dos filmes obtidos foi realizada usando-se espectroscopia de imped?ncia eletroqu?mica (EIS) para obten??o dos par?metros el?tricos, reflex?o total atenuada na regi?o do infravermelho (IV-ATR) e difra??o de raios X (DRX) para estudo da composi??o estrutural e qu?mica, enquanto que a estabilidade t?rmica foi analisada usando termogravimetria (TG/DTG), an?lise t?rmica diferencial (DTA) e calorimetria diferencial de varredura (DSC); as caracter?sticas morfol?gicas e topogr?ficas dos filmes foram analisadas por microscopia ?tica (MO) e eletr?nica de varredura (MEV). A adi??o do sal promoveu modifica??es do padr?o de disposi??o das cadeias polim?ricas, observado por difra??o de raios X e ratificado por altera??es das bandas relativas ? deforma??o angular ?CH2? em cadeia e estiramento assim?trico ?C?C? em cadeia, sugerindo mudan?as estruturais na cadeia polim?rica. A miscibilidade entre os pol?meros poli(metacrilato de metila) e poli(etileno glicol) foi resultado da presen?a de intera??es intermoleculares do tipo liga??o de hidrog?nio entre o ?CO? do PMMA e os grupos OH do PEG e do sal tungstato de s?dio, evidenciadas nas an?lises por IV-RTA, assim como, intera??es puramente eletrost?ticas. Os sistemas apresentaram melhores caracter?sticas capacitivas e maiores tempos de relaxa??o, favorecidos pelo aumento da concentra??o do tungstato de s?dio, resultado da melhora da sensibilidade do ac?mulo de cargas no eletrodo.
As energy demands were being presented and required by technological advances, the synthesis of new materials capable of meeting these needs, was and has been thoroughly studied and performed; among these materials are composite polymeric films that have stood out as an alternative chemistry, physics, electrical and economically viable. In this work self-supporting thin films of poly(methyl methacrylate) (PMMA) in the form of blends, linked to poly (ethylene glycol) (PEG), and composite doped with sodium tungstate dihydrate were obtained by combining the sol-gel methods and casting. The electrical, structural, chemical and morphological characterization of the films obtained was performed using electrochemical impedance spectroscopy (EIS) to obtain the electrical parameters, attenuated total reflection in the infrared (IR-ATR) and X-ray diffraction (XRD) to study the structural and chemical composition, while the thermal stability was evaluated using thermogravimetric analysis (TGA), differential thermal analysis (DTA) and differential scanning calorimetry (DSC); morphological and topographical characteristics of the films were analyzed by optical microscopy (OM) and scanning electron (SEM). The addition of the salt promoted standard modifications of the arrangement of the polymer chains, observed by X-ray diffraction and confirmed by the changes of the bands relative to the angular deformation -CH2- chain and asymmetric stretching -C-C-chain, suggesting structural changes in polymer chain. The miscibility between the polymers poly (methyl methacrylate) and poly (ethylene glycol) was a result of the presence of intermolecular interactions type hydrogen bonding between the PMMA and -CO- OH groups of the PEG and sodium tungstate salt, highlighted in analyzes by IR-ATR as well as purely electrostatic interactions. The systems showed better capacitive characteristics and larger relaxation times, favored by increasing the concentration of sodium tungstate, a result of improved sensitivity of the charges accumulated in the electrode.
Gil, Alvaradejo Gabriela [Verfasser], and G. [Akademischer Betreuer] Delaittre. "New Functional Poly(2-alkyl-2-oxazoline)s and Alternatives to PEG in Protein Stabilization / Gabriela Gil Alvaradejo ; Betreuer: G. Delaittre." Karlsruhe : KIT-Bibliothek, 2018. http://d-nb.info/1162540826/34.
Full textGunnarsson, Marcus, and Olof Palmquist. "Mätning och utvärdering av intellektuellt kapital inom aktiemarknaden." Thesis, Växjö University, School of Management and Economics, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-755.
Full textOrganisation/Organisation Författare/Authors
Växjö Universitet Marcus Gunnarsson
Ekonomihögskolan Olof Palmquist
Växjö University
School of Management and Economics
Dokumenttyp/Type of document Handledare/Tutor
Examensarbete/ Diplomawork Stig Malm Examinator/Examiner
Rolf G Larsson
Titel och undertitel/Title and subtitle
Mätning och utvärdering av intellektuellt kapital inom aktiemarknaden/ Measurement and evaluation of intellectual capital within the stock market
Sammanfattning
Bakgrund: I dagens hårda konkurrens i samhället går trenden mot en informations- och kunskapsbaserad ekonomi där kunskapsföretagen blir fler och fler. Den största tillgången i företagen är de anställda och deras kompetens. Denna kompetens kan omvandlas till en värdefull tillgång och benämns som intellektuellt kapital. Trots att det finns ökad förståelse för att det intellektuella kapitalet skapar mervärde för företaget finns det hinder med att redovisa detta då det inte får tas upp i balansräkningen.
Syfte: Uppsatsens syfte är att analysera huruvida intellektuellt kapital är något som fondförvaltare utvärderar när de gör en investeringsbedömning.
Avgränsningar: Begränsningarna är att vi undersöker hur intellektuellt kapital kan vara till fördel för endast fondförvaltare; vi analyserar olika fondförvaltare i deras arbete endast med en investeringsbedömning. En sista avgränsning är att vi valt att inte tillfråga de fondförvaltare som inte utvärderar intellektuellt kapital aktivt i sina investeringsbedömningar.
Metod: Vi har utgått från en kvantitativ metod och har genomfört en enkätundersökning för insamling av material. Resultatet har vi analyserat utifrån den teori som vi tagit upp i det teoretiska kapitlet. Ansatsen är av abduktiv karaktär åt det deduktiva hållet då vi har studerat existerande teorier och fallstudier inom ämnet.
Resultat, slutsatser: Svenska fondanalytiker lägger inte särskilt stor vikt på intellektuellt kapital när de utvärderar och analyserar ett företag. Grunden till detta är för det första att det är svårt att mäta trovärdigheten av intellektuellt kapital när företagen själva sammanställer och redovisar detta utan att kontrolleras av någon utomstående part. För det andra är korrelationen mellan större delen av ett företags strukturkapital och aktiens utveckling på börsen inte påvisbar.
Förslag till fortsatt forskning: Ett redovisningssystem för intellektuellt kapital som är lika för alla inom samma bransch möjliggör fortsatt forskning inom ämnet med syftet att finna en analysmetod som påvisar eller dementerar förändringen av ett företags intellektuella kapital med företagets aktierörelse på börsen.
Nyckelord
Intellektuellt kapital, Humankapital, Strukturkapital, Kundkapital, Immateriella tillgångar, Soliditet, Likviditet, Lönsamhet, P/E-tal, PEG-tal, P/S-tal
Key Words
Intellectual capital, Human capital, Capital structure, Customer capital, Immaterial assets, Solidity, Liquidity, Profitability, P/E, PEG, P/S
Utgivningsår/Year of issue Språk/Language Antal sidor/Number of pages
2006 Svenska/Swedish 37
Internet: http://www.vxu.se/ehv
Kailasan, Arunvel. "Synthesis and characterization of novel temperature-responsive dendritic PEG-PDLLA star polymers for drug delivery." VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/1630.
Full textGuerri, Riccardo. "Re_interpretare per vivere. Una nuova unita per s. Maria della misericordia a venezia." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/6888/.
Full textLima, Neto Heleno Carlos. "Estudo da atividade s?smica em S?o Caetano-PE em 2007." Universidade Federal do Rio Grande do Norte, 2009. http://repositorio.ufrn.br:8080/jspui/handle/123456789/18758.
Full textConselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico
In this dissertation we studied the seismic activity in the S?o Caetano county, Pernambuco State, Northeastern Brazil, located near the Pernambuco Lineament. The Pernambuco Lineament is a one of Neoproterozoic continental-scale shear zones that deforms the Borborema province. The seismicity estudied occurred in a NE trending branch of Pernambuco Lineament. The seismic activity in S?o Caetano started in 2006 and in May 20th, 2006 a 4,0 mb earthquake hit there. This was the largest earthquake ever reported in Pernambuco State. This dissertation is the result of a campaign done in the period from Februay 1th 2007 to July 31 th 2007. In this campaign up to nine three-component digital seismographic stations were deployed and the collected data was used to determine hypocenters and focal mechanism. A total of 214 earthquakes, recorded at least by three stations, were analyzed. To determine hypocenters and time origin the HYPO71 program was used assuming a half-space model with parameters : VP (P-wave velocity) equal to 5.90 km/s and the ratio VP/VS 1.70, where VS is the S-wave velocity. The earthquakes hypocentral distribution was approximately 4 km long and agrees with the NE-SW direction of the Pernambuco Lineamento branch. Hypocentres depth range from 2 to 8 km. The composed focal mechanism was made from a group of 14 selected earthquakes. We try firstly to find the fault plane solution matching the polarity distribution at stations, using the FPFIT program. The result was 43 deg ? 15 deg for strike, 59 deg ? 9 deg for dip and -142 deg ? 15 deg for rake. We also fitted a plane using the hypocentral distribution to obtain the dip and azimuth of the hypocentral distribution. The results obtained by this fit were 58 deg for the azimuth, 55 deg for the dip and -155 deg for rake. This result shows a mechanism of a strike-slip dextral fault with a normal component. This dissertation shows, once more, that there is a good correlation between the seismic activity and geological features in the region near the Pernambuco Lineament and its NE branches
Nesta disserta??o foi estudada a atividade s?smica no munic?pio de S?o Caetano, estado de Pernambuco, Nordeste brasileiro, localizado pr?ximo ao Lineamento Pernambuco. O Lineamento Pernambuco ? uma zona de cisalhamento Neoproteroz?ica de escala continental que deforma a prov?ncia Borborema. A sismicidade estudada ocorreu numa ramifica??o para nordeste do Lineamento Pernambuco. A atividade s?smica em S?o Caetano iniciou em 2006 e no dia 20/05/2007 ocorreu, neste munic?pio, um sismo de magnitude 4,0 mb. Este ? o sismo de maior magnitude que ocorreu no estado de Pernambuco. Este trabalho ? decorrente da an?lise de dados coletados durante o per?odo de monitoramento na regi?o que foi de 01/02/2007 at? 21/07/2007. Nesse monitoramento foi utilizado de seis at? nove esta??es sismogr?ficas digitais. Os dados coletados por essas esta??es foram analisados, objetivando a determina??o dos hipocentros e do mecanismo focal composto. Foram utilizados 214 sismos, registrados em pelo menos tr?s esta??es. Na determina??o hipocentral, foi utilizado o programa HYPO71, assumindo-se um modelo de semi-espa?o, com os par?metros: velocidade da onda P (VP) e raz?o VP/VS, respectivamente, 5,90 km/s e 1,70. Os hipocentros dos sismos ocorridos na regi?o deste estudo acompanham uma ramifica??o para nordeste do Lineamento Pernambuco e possui aproximadamente 4km de extens?o e profundidade variando entre 2 at? 8 km. O mecanismo focal composto foi feito para um conjunto de 14 sismos selecionados. N?s primeiramente tentamos encontrar a solu??o do plano de falha considerando apenas a distribui??o de polaridades utilizando o programa FPFIT. Os resultados foram: 43? ? 15? para o azimute, 59? ? 9? para o mergulho e -142? ? 15? para o rake. N?s tamb?m ajustamos o plano usando a distribui??o hipocentral. Os resultados obtidos foram: 58? para o azimute, 55? para o mergulho, O valor do rake foi fixado em -155?. Este resultado mostra um mecanismo de uma falha transcorrente dextral com uma componente normal. Esta disserta??o mostra, mais uma vez, que existe uma boa correla??o entre a sismicidade e falhas mapeadas na regi?o pr?xima ao Lineamento Pernambuco e suas ramifica??es para nordeste
STRAULLU, STEFANO. "Next generation optical access networks towards Gigabit/s per user." Doctoral thesis, Politecnico di Torino, 2015. http://hdl.handle.net/11583/2592360.
Full textPalou, Marín Roger. "Control de la mitosi pel mecanisme de vigilància de fase S." Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/285609.
Full textThe S phase checkpoint is a surveillance mechanism in eukaryotic cells that preserve genomic integrity in response to genotoxic insults. This checkpoint inhibits mitosis onset till the stress has been solved, avoiding genomic instability that results from the segregation of damaged or not fully replicated chromosomes. Eukaryotic cell cycle and its regulation mechanisms, like the S phase checkpoint, have been initially identified and studied in model organisms like Schizosaccharomyces pombe (fission yeast) and Saccharomyces cerevisiae (budding yeast) and these mechanisms and factors are conserved in humans. Mitosis control in fission yeast in the presence of replication stress relies on the inhibition of mitotic Cdk1 through tyrosine 15 Wee1 mediated phosphorylation. However, in budding yeast, Wee1 ortholog Swe1 and its phosphorylation over Cdk1, seems unnecessary in this control. The present model for budding yeast control of mitosis in the presence of DNA damage relies on the stabilization of Pds1/securin. This chaperone inhibits Esp1/separase which cleaves cohesin, the protein that keeps sister chromatids together. In humans, Wee1 and its phosphorylation over Cdk1 are conserved but they are not enough to inhibit mitotic Cdk1 activity and completely avoid mitosis onset in the presence of genotoxic stress. Our results show that in budding yeast, mitotic Cdk1 is inhibited in the presence of genotòxic stress. Swe1 dispensability is explained by a redundant mechanism regulating mitotic Cdk1 mediated by Swe1 and Rad53, the effector kinase of the S phase checkpoint. Moreover, Swe1 levels stabilization in the presence of genotoxic stress is mediated by the S phase checkpoint. Mitotic Cdk1 deregulation or pds1Δ is not enough to observe DNA segregation in the presence of genotoxic stress. Only cells that cannot regulate mitotic Cdk1 activity together with pds1Δ are able to segregate not fully replicated or damaged chromosomes.
Salter, A. Hugh. "Genetics and biogensis of the pea chloroplast Rieske Fe-S protein." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335798.
Full textZoli, Enrico. "CAO=S un modello di progettazione goal oriented per interfacce web." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amslaurea.unibo.it/1243/.
Full textRibeiro, Fernanda Alves. "Caracteriza??o de comp?sito ep?xi/tecido de pet p?s-consumo." PROGRAMA DE P?S-GRADUA??O EM ENGENHARIA MEC?NICA, 2016. https://repositorio.ufrn.br/jspui/handle/123456789/22216.
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O consumo esmagador de Polietileno tereftalado (PET) grau garrafa constitui cap?tulo ? parte entre as resinas produzidas no Brasil. Embora o pa?s consiga reciclar mais da metade da produ??o de PET, ainda ? muito elevado o volume deste material em forma de garrafas. Salienta-se que, apesar do benef?cio da resina PET poder ser utilizada em in?meras aplica??es e sob diversos processos, ? necess?rio desenvolver alternativas de seu reuso na via de reciclagem. Nesta vertente, o objetivo da pesquisa foi avaliar a aplica??o do tecido de pet, oriundo do processo de reciclagem das garrafas, como refor?o de comp?sitos polim?ricos. Para tanto, na metodologia utilizada, ap?s a preliminar caracteriza??o do tecido de pet via ensaios t?xteis (Determina??o de gramatura; Resist?ncia ? propaga??o ao rasgo; Resist?ncia ? tra??o e alongamento), confeccionou-se laminados comp?sitos polim?ricos com matriz ep?xi e diferentes fra??es de tecido para a verifica??o e an?lise de suas principais propriedades f?sico-qu?micas, mec?nicas e t?rmicas. Os seguintes ensaios foram realizados nos corpos de prova de resina e laminado comp?sito: Densidade; Absor??o de ?gua; Teor de umidade; Tra??o uniaxial; Flex?o em tr?s pontos; Compress?o; Dureza; TG; DMA e An?lise de fratura. A an?lise dos resultados evidenciou que o incremento de camadas de tecido propicia ao comp?sito o aumento nas resist?ncias ? tra??o e ? compress?o; al?m do que, eleva a rigidez viscoel?stica do material, ao passo que diminui a resist?ncia ? flex?o. Observou-se tamb?m que as camadas de tecido de PET diminuem o teor de umidade do comp?sito, bem como a sua capacidade de absor??o de ?gua. Contudo, as propriedades Dureza e Densidade n?o apresentaram varia??o significativa com a inclus?o do tecido de PET. A configura??o P90, com o m?ximo teor de tecido de PET no laminado, exprimiu-se como a de melhor desempenho frente aos ensaios realizados. Deste modo, a utiliza??o do tecido PET evidencia aspectos atraentes para as iniciativas empresariais do setor. A composi??o P90, como refor?o de comp?sito polim?rico, foi a que apresentou melhor resultado. Esse material tr?s reflexos socio-econ?micos diretamente relacionados com a melhoria da qualidade de vida da popula??o, gera??o de renda, economia de recursos naturais e atenua??o de problemas ambientais.
There is no doubt whatsoever that the widest consumption of polyethylene terephthalate (PET) bottle grade is a unique chapter among the resins produced in Brazil. Although the country is able to recycle more than a half of all PET production, the number of such material for bottle fabrication is still very high. It is important to remark that, though all benefits of PET resin uses in uncountable applications and under many processes; alternatives to its reuse throughout recycling dynamics must be developed. Thus, this work aims at evaluating the application of PET fabric coming from the process of bottle recycling polymeric composite reinforcements. In order to do so, after a preliminary characterization of the PET fabric by textile tests (Grammage determination; Tear propagation resistance; Tensile strength and elongation resistance), laminated polymeric composite with epoxy matrix as well as different fractions of fabric for checking and analysis of their main physicochemical, mechanical and thermal properties were engendered. The following tests were performed with the resin and with laminated composite: Density, Water absorption; Moisture content; Uniaxial tensile; Three point flexural test; Compression; Hardness; TG; DMA and Fracture analysis. By analyzing the results, it was noticed that the increase of fabric layers provide a resistance and compression gain to the composite, and it also increases the material viscoelastic stiffness, at the same time as its flexural strength is diminish. It was also noticed that its water absorption capacity was diminished. Nevertheless, its hardness and density properties did not present meaningful variation with the PET addition. The P90 setting with the highest content of PET fabric in the laminate presented itself as having the best results in the tests. Therefore the use of PET fabric presents attracting aspects to entrepreneurship. P90 configuration used as polymeric composite reinforcements were the one to present the best results. Such material brings socio-economical reflexions directly linked to the improvement of livelihood, natural resources economy and offset environment problems.
Roudnický, Tomáš. "Search Engine Optimization a jeho efektivita ve srovnání s Pay-per-Click reklamou." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-81599.
Full textVolken, Werner. "Strangelet search in S - W collisions at 200 · A GeV/c per nucleon /." [S.l.] : [s.n.], 1994. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Full textLovera, Renata de Rezende. "Agressividade no per?odo da lat?ncia atrav?s do teste contos de fadas." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2009. http://tede2.pucrs.br/tede2/handle/tede/641.
Full textComo uma das a??es desempenhadas pelos seres humanos, encontra-se a agress?o - comportamento que faz parte do cotidiano das pessoas, e, se bem gerenciada, auxilia o indiv?duo a se afirmar e a obter satisfa??o, considerando o contexto social no qual est? inserido. Entretanto, a agress?o est? comumente associada ? viol?ncia, que ? considerada um comportamento mal-adaptativo, como car?ter destrutivo das pessoas. Presente desde as etapas iniciais do desenvolvimento, torna-se relevante compreender o fen?meno ps?quico da agress?o na inf?ncia, como forma de conhecer e definir formas de interven??es adequadas na cl?nica psicol?gica infantil com o objetivo de a??es de preven??o. Para tanto, foram elaboradas duas se??es de estudo: uma te?rica e uma emp?rica. A se??o te?rica apresenta uma revis?o da contribui??o dos te?ricos da psican?lise para compreens?o da agressividade. Discute-se a import?ncia da agress?o para os diferentes autores e tamb?m se contextualiza como a agressividade est? presente nas fases do desenvolvimento infantil, a partir de um enfoque no per?odo da lat?ncia. Nesta etapa do desenvolvimento, que se caracteriza por um equil?brio entre impulso e defesas mais elaboradas, a utiliza??o de mecanismos defensivos, como a sublima??o, instrumentaliza a crian?a para superar situa??es dif?ceis de car?ter agressivo. Na se??o emp?rica, ? retratado um estudo quantitativo, do tipo transversal, que busca identificar a presen?a de evid?ncias de conte?dos agressivos nas respostas ao Teste dos Contos de Fadas (TCF), instrumento projetivo tem?tico. Participaram do estudo 72 crian?as dos sexos feminino e masculino, com idades entre 6 e 11 anos, de escolas p?blicas e privadas da cidade de Porto Alegre. A fim de obter dados que caracterizem os participantes, foi utilizada uma Ficha de Dados Sociodemogr?ficos. Para excluir casos com suspeita de comprometimento intelectual, foi administrado o Teste Matrizes Progressivas Coloridas de Raven - Escala Especial. Todo o material verbalizado pelas crian?as ao Teste dos Contos de Fadas (TCF) foi avaliado por tr?s ju?zes (J1, J2 e J3) que realizaram avalia??es com base no sistema de categoriza??o de respostas. Para avaliar o grau de concord?ncia entre eles, foi utilizada a estat?stica Kappa. Posteriormente, foi realizado um levantamento de freq??ncias dos tipos de conte?dos agressivos identificados nas respostas e, para a compara??o entre grupos e associa??es das vari?veis conforme escola, sexo e idade, tem?tica/conflito da s?rie de cart?es, foi utilizado o Teste Exato de Fisher. Os resultados mostram que o grau de concord?ncia entre os ju?zes, na sua maioria, foi satisfat?rio, uma vez que a concord?ncia alcan?ada foi, predominantemente, de valores moderados, substancias e quase perfeitos na maioria das categorias da agress?o. Os conte?dos agressivos com maior freq??ncia de respostas foram: Medo de Agress?o (f = 54), Agress?o Tipo A (f=49) e Agress?o como Retalia??o (f=34). Foi identificada associa??o significativa entre a vari?vel Agress?o Tipo A e sexo masculino (p=0,042). Foi poss?vel identificar as freq??ncias da vari?vel agress?o em seis das sete s?ries de cart?es (Chapeuzinho Vermelho, Lobo, An?es, Bruxa, Gigante, Cenas do Conto Chapeuzinho Vermelho). Os resultados obtidos apontam que, mesmo o per?odo da lat?ncia sendo considerado um per?odo de espera para as etapas posteriores, na qual a crian?a est? mais calma, ? poss?vel identificar a exist?ncia de motiva??es que levam a crian?a a agir de forma agressiva.
Silva, S?rgio Luiz Eduardo Ferreira da. "Tensor momento s?smico para eventos no nordeste do Brasil com amplitudes espectrais: estudos em S?o Caetano, PE." PROGRAMA DE P?S-GRADUA??O EM GEODIN?MICA E GEOF?SICA, 2016. https://repositorio.ufrn.br/jspui/handle/123456789/21887.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES)
O estudo da fonte s?smica ? importante para um melhor entendimento dos processos f?sicos din?micos geradores de sismos e para investiga??es sismotect?nicas de uma regi?o. Neste trabalho, alteramos uma metodologia existente para determina??o do tensor momento s?smico atrav?s da invers?o das amplitudes espectrais de ondas de corpo, que ? testada com eventos locais registrados nas proximidades de S?o Caetano, em Pernambuco, no nordeste do Brasil. A metodologia consiste em minimizar a diferen?a entre os valores observados e previstos das amplitudes espectrais ? com polaridade - de ondas P, SV e SH, para determina??o dos seis componentes independentes do tensor momento s?smico. A metodologia original foi desenhada para inverter amplitudes espectrais de ondas diretas em eventos induzidos em minas profundas e registrados em redes sismogr?ficas subterr?neas. Em nosso estudo, propomos altera??es para adequa??o desta metodologia para eventos tect?nicos registrados em superf?cie. Com isso, ? preciso remover os efeitos da superf?cie terrestre a partir dos tr?s componentes s?smicos registrados no sismograma para recuperar as formas de onda P, SV e SH incidentes e, assim medir sua amplitude espectral. Para ?ngulos de incid?ncia pr?-cr?ticos, a corre??o ? facilmente realizada atrav?s da divis?o do componente vertical das formas de onda P e SV por seus correspondentes coeficientes de reflex?o da superf?cie livre; para ?ngulos de incid?ncia p?s-cr?ticos, uma corre??o mais sofisticada envolvendo a transformada de Hilbert das formas de onda registradas ? necess?ria para remover a distor??o da forma de onda introduzida pela mudan?a de fase. A metodologia proposta ? extremamente vantajosa, visto que utiliza informa??es dos padr?es de radia??o tanto das ondas P quanto das ondas S para determinar o mecanismo focal de eventos individuais. Testamos com 16 terremotos registrados em dist?ncias locais ( < 10 km) por uma rede sismogr?fica implantada na localidade de S?o Caetano, PE, entre 15 de setembro e 23 de dezembro de 2010. Por fim, comparamos com um mecanismo focal composto desenvolvido em trabalhos anteriores na zona de estudo a partir de polaridades da onda P e verificou-se uma consist?ncia com as nossas solu??es do tensor momento, o que demonstra a aplicabilidade do m?todo aqui proposto para registros locais em superf?cie. Al?m disso, a metodologia apresentada permite estimar a magnitude momento (MW) para os eventos analisados.
The study of the seismic source is important to improve our understanding of the physical processes that trigger earthquakes, and also for seismotectonics investigations of a region. In this work, we modify an existing methodology for determination of the seismic moment tensor by inversion of spectral amplitudes, and test it with events recorded at local distances near Sao Caetano, Pernambuco, in northeastern Brazil. The methodology consists of minimizing the difference between observed and predicted values of the spectral amplitudes ? with polarity attached - of P, SV and SH waves, to determine the six independent components of the moment tensor. The original methodology inverts spectral amplitudes of direct waves for events in deep mines and recorded at underground seismographic networks. In our study, we adapt this methodology to tectonic events recorded by surface networks. First, the effects of the Earth's free surface are removed from the seismic recordings to recover the incident P, SV and SH waves; then, the corresponding spectral amplitudes are measured and a polarity is attached; finally, the spectral amplitudes are inverted in a least squares sense. At pre-critical incidence angles, the correction is easily achieved by dividing the vertical component of the P and SV waveforms by the corresponding free-surface reflection coefficients; at post-critical incidence angles, a more sophisticated correction involving the Hilbert transform of the recorded waveforms is needed to account for waveform distortion introduced by the coefficient?s phase shift. Correction of the SH components is achieved through division by a factor of 2. The proposed methodology is extremely advantageous since it uses the radiation patterns of both P and S waves to determine the focal mechanism of individual events. The adapted methodology is applied to 16 earthquakes recorded at local distances (< 10 km) by an aftershock network deployed in the locality of S?o Caetano, PE, between September 15th and December 23rd, 2010. Comparison with a composite focal mechanisms developed in previous works in the study area from fist-motion polarities shows consistency with our moment tensor solutions, thus demonstrating the portability of the spectral amplitude method. Additionally, the ported methodology allows the estimation of moment magnitudes for individual events.
Piffero, Alfeu Cl?udio Monteiro. "Repercuss?o funcional da congru?ncia talonavicular no p?s-operat?rio do p? torto cong?nito idiop?tico." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2008. http://tede2.pucrs.br/tede2/handle/tede/1477.
Full textOBJETIVO - Descrever a amostra de indiv?duos com p? torto cong?nito idiop?tico tratados cirurgicamente de 1986 a 2002 no Hospital S?o Lucas da Pontif?cia Universidade Cat?lica do Rio Grande do Sul (HSL-PUCRS). Verificar associa??o entre os achados radiogr?ficos da articula??o talonavicular e o escore funcional de p?s tortos cong?nitos idiop?ticos tratados cirurgicamente de maneira uniforme. METODOLOGIA Cinq?enta crian?as (71 p?s) que realizaram cirurgia para corre??o de p? torto cong?nito idiop?tico no per?odo de 1986 a 2002 no HSL-PUCRS, participaram deste estudo. Para desenvolvimento deste trabalho foi realizada revis?o dos prontu?rios hospitalares visando a cria??o de um banco de dados com vari?veis de interesse relacionadas ? avalia??o p?s-operat?ria. Foi realizada an?lise descritiva dos dados e, posteriormente, de associa??o. RESULTADOS A amostra foi composta por 34 pacientes do sexo masculino (48 p?s) e 16 do sexo feminino (23 p?s) submetidos a tratamento cir?rgico no HSL-PUCRS. A avalia??o dos p?s pelos crit?rios de Simons mostrou 38 p?s centrados (53,5%), 25 p?s com complica??es menores (35,2%) e 8 p?s com complica??es maiores (11,3%) nas radiografias em ?ntero-posterior (AP). Nas radiografias em perfil (P), encontramos 31 p?s centrados (43,7%), 27 complica??es menores (38%) e 13 complica??es maiores (18,3%). Os resultados funcionais, segundo a tabela de Laaveg e Ponseti, mostraram escores variando de 47 a 100 pontos (pts), com m?dia de 86,86 pts e desvio padr?o (dp) 11,08, mediana de 88 pts e moda de 97 pts. CONCLUS?O As varia??es encontradas nas radiografias em AP e P da articula??o talonavicular dos p?s pelos crit?rios de Simons, n?o mostraram associa??o estatisticamente significativa com os escores de fun??o avaliados pela tabela de Laaveg e Ponseti.
Tatjer, Recordà Laura. "Aproximacions genètiques per l’estudi de les funcions de la proteïna fosfatasa Ptc1 en S. cerevisiae." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/287896.
Full textType 2C protein phosphatases (PP2Cs) form a family of monomeric enzymes conserved throughout evolution. In the yeast Saccharomyces cerevisiae, there are seven structurally related genes that encode different isoforms of PP2Cs (PTC1-7). Ptc1 is the most studied PP2C isoform in yeast because this phosphatase can perform multiple specific functions not shared by the other PP2Cs. As a result, a ptc1 mutant fails to grow against various forms of stress such as those that activate the cell wall signaling pathway (eg. alkaline pH , Calcofluor white and caffeine), in the presence of cations (LiCl, CaCl2, ZnCl2, …), rapamycin (an inhibitor of the TOR pathway that mediates the lack of nutrients response) or in plates with ethanol as the sole carbon source. A ptc1 mutant also presents defects in organelle inheritance such as mitochondria, endoplasmic reticulum or vacuoles, among many other defects. Despite all of these alterations only two substrates of this isoform are known: the Hog1 kinase involved in osmoregulation, and the pheromone-responsive MAPK scaffold protein Ste5. The aim of this study is to identify possible functional mechanisms of Ptc1. Due to methodological difficulties inherent in working with phosphatases, we designed two genetic approaches to achieve our goal. The first strategy was based on the screen of yeast genomic library to find genes that, when overexpressed in a ptc1 mutant, abolish or alleviate the sensitivity of this strain to alkaline pH, Calcofluor white or rapamycin. As a result we identified a total of 25 genes that alleviate one or several characteristic phenotypes of the ptc1 mutant. Most of these genes were classified into three functional groups: cell cycle regulation, vacuolar function and protein sorting, and cell wall integrity. We present a model where the hyperactivation of the Slt2 MAPK module would decrease the activity of Cdc28, which could become limiting in a ptc1 mutant. This would represent the first evidence of a possible role of Ptc1 on cell cycle regulation. We have focused on the relationship between Ptc1 and the two suppressors that exhibited the strongest ability to recover different phenotypes: PPH21 and PPH22, which encode two redundant catalytic subunits of protein phosphatase type 2A. The results indicate that loss of Ptc1 alters different PP2A complexes that act as effectors of the TOR pathway when it is inhibited. The second genetic approach was based on the hypothesis that the ptc1 mutant defects are probably due to an hyperphosphorilated state of one or more Ptc1 substrates. Therefore, we generate a collection of 115 mutants in which we combined the deletion of nonessential genes encoding catalytic subunits of protein kinases or their regulatory proteins with the ptc1 mutation, and analyzed their growth in eight different conditions in which the ptc1 mutant is sensitive. Integration of the results allowed detecting a wide variety of genetic interactions between Ptc1 and different kinases, in agreement with the wide functional spread of the Ptc1 phosphatase. However, only the Mkk1 mutation (one of the two MAPKK of the cell wall integrity pathway) can lighten or eliminate all phenotypic defects studied in the ptc1Δ strain. The data obtained show that at least part of ptc1 defects are related to the hyperactivation of the Slt2 kinase downstream Mkk1, reinforces the idea that Mkk1 is the main MAPKK acting on Slt2 signaling, and points to Mkk1 as a likely target for the Ptc1 phosphatse.
Scott, Patricia. "Women in the novels of Benito PeÌrez GaldoÌs and Eça de Quieroz." Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412190.
Full textCHAGAS, MARCOS ANTONIO MACEDO DAS. "YOUTH AND ADULT EDUCATION: THE PEJ S EXPERIENCE IN THE CITY OF RIO DE JANEIRO." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2003. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=4190@1.
Full textThe present study has the purpose of examining, from a reflection on the history of adult education, the successive educational policies destined to individuals who are 15 years old or more and were unable to continue studying. Since the early Brazilian Republic, adult education is based on popular education, which frequently rejected permanent programs. Therefore, the educational level of youngsters and adults has not achieved significant progress. On the other hand, intensive (supletivo) adult education is a constant in our history, being organized according to labor market demands. With the employment crisis, which worsened since the 1990s, a situation that extinguished hundreds of labor positions, adult education has changed its focus. The advance of neoliberalism, emphasizing multi-purpose, proactive, autonomous and flexible workers, has classified labor achievements of the past - which somehow protected workers from inequalities caused by capital - as obsolete and retrograde. Such older labor achievements were denounced as responsible for the capitalist crisis, and workers who symbolized an age of class progress and unions were kept away from the scarce job offers. Since the 1980s, in Brazil, the young individual, an icon of such new times, has been retrieved and brought back to the scene. Such labor actions, being connected to the history of adult education, have lead us to investigate how the phenomenon of juvenilization is taking place within Juvenile and Adult Education programs. We have decided to focus our studies on a basic education program named Projeto de Educação Juvenil (PEJ, Juvenile Education Project) by the Municipal Education Department of the City of Rio de Janeiro, seeking to understand how the relations between youngsters and adults are being structured within this Project.
Melo, Fernanda Colpo de. "S?ntese do PET-CO-PLLA e avalia??o da biodegrada??o em solo preparado." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2009. http://tede2.pucrs.br/tede2/handle/tede/3134.
Full textEste trabalho apresenta um estudo sobre a reciclagem qu?mica do poli(tereftalato de etileno) (PET) p?s-consumo atrav?s da s?ntese de novos copoli?steres alif?ticoarom?ticos obtidos a partir da polimeriza??o em massa, em altas temperatura (240 ?C), do poli(?cido L-l?ctico) com o PET p?s-consumo em diferentes propor??es em massa. Ap?s a s?ntese e caracteriza??o dos copol?meros realizou-se o processo de degrada??o em solo preparado pelas normas da ASTM G160 International. Atrav?s dos espectros de RMN 1H e FTIR foi poss?vel confirmar a forma??o dos copol?meros. Tamb?m, foi evidenciado pelos dados de DSC, TGA e MEV que os copol?meros que possuem menor teor de PET degradam com mais facilidade e possuem menor estabilidade t?rmica. Contudo, podemos observar que esta reciclagem qu?mica do PET ? um m?todo importante para ajudar na resolu??o do impacto ambiental gerado pelo ac?mulo deste material, que possui boas propriedades mec?nicas, alta resist?ncia qu?mica aliada ? alta produ??o.
Franzén, Therese, and Jenny Sundqvist. "Betydelsen av Fluorodeoxyglukos Positron Emissions Tomografi (18F-FDG PET) för att detektera Alzheimer´s sjukdom." Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-91844.
Full textGiraud, Cédric. "Per verba magistri : Anselme de Laon, son école et le mouvement théologique du XIIe s." Paris 4, 2006. http://www.theses.fr/2006PA040145.
Full textAnselm of Laon was one of the major teachers in the first half of the 12th century. The example of Anselm of Laon made it possible to consider the way medieval masters in theology reached an authority. Thanks to his career, his theological sentences and treatises connected with his teaching, we can see how a theological school grew. This new authority appeared clearly around 1130-1140 : the diffusion of the anselmian sentences and the writing of the treatises took place during these years
Ferranti, Francesca. "Il metodo Level(S) per il confronto dei profili ambientali di diverse soluzioni di involucro edilizio." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019.
Find full textBelfrage, Sean, and Adrian Ahmadi. "Investigating the Accuracy of Analyst Consensus for Earnings per Share of S&P 100 companies." Thesis, KTH, Matematisk statistik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-168017.
Full textDenna studie syftade till att undersöka vad som påverkar hur noggrant finansanalytiker kan förutsäga resultatet per aktie för företag som ingår i Standard & Poors 100 index. För att uppnå detta mål samlades data om vinstprognoser in för åren 2000 till 2013. Vidare syftade denna studie till att undersöka om det finns någon skillnad i noggrannhet hos optimistiska respektive pessimistiska konsensusprognoser. Multipla linjära regressioner användes för att besvara dessa frågor. De faktorer som denna studie fann har påverkan på prognosprecisionen är konsensusdispersion, företagsstorlek, nettomarginal, vilken börs företaget är noterat på och, i viss mån, ett företags industriklassificering. Vidare visar resultaten av studien att det inte finns någon skillnad i noggrannheten för optimistiska respektive pessimistiska konsensusprognoser. I denna studie kunde modellerna som användes, och faktorerna som undersöktes, bara förklara en begränsad del av vad som påverkar en resultatprognos noggrannhet. Slutligen fördes en kvalitativ diskussion kring vilka faktorer som påverkar träffsäkerheten ytterligare, men som var svåra att implementera i denna kvantitativa studie.
Madureira, Jos? Gabriel Periss? "O encontro como categoria teol?gica a partir da obra de Alfonso L?pez Quint?s." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2018. http://tede2.pucrs.br/tede2/handle/tede/8222.
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The definition of encounter, according to the Spanish philosopher Alfonso L?pez Quint?s, is the starting point for to draw around the encounter as a theological category. The purpose was to clearly identify the essential characteristics and the fruits of the interpersonal encounter, as well as the discovery of the values and the longing for transcendence. When contrasting the theory of the encounter of L?pez Quint?s with the work of different philosophers, theologians and thinkers who focused on the idea of "encounter with God", it is possible to glimpse and make explicit, in the work of this author, the main features of a legitimate theology of the encounter.
A partir do pensamento do fil?sofo espanhol Alfonso L?pez Quint?s, tenciona-se delinear nesta disserta??o o encontro como categoria teol?gica, identificando com clareza as caracter?sticas essenciais, as exig?ncias e os frutos do encontro interpessoal, da descoberta dos valores que decorrem do encontro e do desejo de transcend?ncia. Contrastando a teoria do encontro de L?pez Quint?s com o trabalho de diferentes fil?sofos, te?logos e pensadores que se debru?aram sobre a ideia de um ?encontro com Deus?, ? poss?vel vislumbrar e explicitar na obra deste autor os principais tra?os de uma leg?tima teologia do encontro.
De, Marchi Agnese <1974>. "Between pen and palette : the image(s) of Venice in the work of F. Hopkinson Smith." Doctoral thesis, Università Ca' Foscari Venezia, 2012. http://hdl.handle.net/10579/1160.
Full textThe aim of this work is to examine the image of Venice in the works of Francis Hopkinson Smith (1838-1915), especially in his most extensive work on Venice, the illustrated travelogue 'Venice of To-Day' which was published in 1895. An engineer, a painter and a writer, Smith was a popular figure in the cultural landscape of nineteenth century America, and like many other American artists he fell under the spell of the 'Queen of the Adriatic'. For more than twenty years, Smith spent every summer in Venice, painting an impressive numbers of Venetian views, mostly watercolors and charcoals, which he would display (and then sell) in highly successful exhibitions in the United States. Nineteenth century American culture viewed Venice as the exotic place 'par excellence', a place where the presence of the past could be fully perceive and which represented the quintessential essence of the picturesque. On the one hand, Smith's representation of Venice was widely influenced by the interpretative conventions of the culture he belonged to, but on the other hand, as the title of his travelogue suggests, he tried to offer a fresher and more authentic view of a city, which had to face the changes brought by modernity. Through the magnifying lens of Smith's writings and watercolors representing Venice, we are given the possibility to explore the way in which American culture perceived and represented this peculiar city both as a real place and an imaginary one.
CAEIRO, Rui Miguel Pereira. "Transexualidade(s) e travestilidade(s) no jornalismo: uma análise discursiva das notícias produzidas em Pernambuco pelo Aqui PE e Jornal do Commercio." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/17750.
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CAPEs
A presente investigação é instigada por dois pressupostos: 1) compreendendo a grande mídia como instituição integrada, e originada, no sistema capitalista, ela é foco de complexas lutas de/pelo poder para/de influenciar a produção de significados e representações sociais – ou seja, é espaço privilegiado no (re)conhecimento da (in)existência e (in)visibilização de vozes, temas e mundos, assim colaborando na (re)construção social da realidade; 2) na sociedade brasileira, pessoas trans constituem um dos grupos político-identitários que maior marginalização sofre diariamente – de ordem estrutural, muitas das violências transfóbicas/ cissexistas que enfrentam são resultado, e resultam, do/no apagamento de suas vozes, historicamente patologizadas/ criminalizadas pelos saberes ‘oficiais’ (principalmente os construídos pela medicina e ciências psi, reproduzidos nos mais variados espaços públicos e privados). Nossa hipótese é que a mídia é, também, espaço de (re)produção de violências e exclusão de pessoas trans – hipótese essa que ao final afirmamos, e justificamos, como verdadeira. Desta forma, o trabalho tem três objetivos centrais: 1) analisar os discursos produzidos (jan.2014 – jan.2015) por Aqui PE e Jornal de Commercio (versões impressas) acerca de transexualidade(s) e travestilidade(s); 2) através de entrevistas semi-estruturadas com alguns dos sujeitos envolvidos na produção noticiosa (editoras/es dos cadernos analisados), lançar pistas sobre algumas das concepções acerca de transexualidade e travestilidade que circulam nas redações dos jornais, bem como sobre outras variáveis que condicionem a construção noticiosa dos temas; 3) alinhavando teorizações provenientes, principalmente, das Teorias do Jornalismo, Estudos Críticos do Discurso e Estudos Queer, refletir sobre as possibilidades de mudança discursiva, portanto social, acerca da(s) transexualidade(s), travestilidade(s) e, necessária-simultaneamente, cisgeneridade(s).
The investigation is instigated by two assumptions: 1) understanding the mainstream media as an institution integrated, and originated, in the capitalist system, it is the focus of complex struggles of/for power to influence the production of meanings and social representations – i.e., its a privileged space for the recognition of (in)existence and (in)visibility of voices, themes and worlds, thus collaborating in the reconstruction of reality; 2) in Brazilian society, transgender people are one of the political/identity groups that, on daily bases, experience social marginalization – structural, many of the transphobic/ cissexists violence they face are the result, and result, from / in the deletion of their voices, historically pathologized/ criminalized by 'official' knowledge (mostly built by medicine and psychological sciences, reproduced in various public and private spaces). Our hypothesis is that the media is, also, space of (re)production of violence and exclusion of transgender people - a hypothesis that at the end we found to be true. Thus, the work has three main objectives: 1) to analyze the discourses produced (jan.2014 - jan.2015) on Aqui PE and Jornal do Commercio (printed versions) about transsexuality(s); 2) through semi-structured interviews with some of those involved in news production (publishers of the analyzed books), provide clues about some of the conceptions of transsexuality circulating in newsroom and newspapers, as well as other variables that condition the construction of news topics; 3) tacking theories derived mainly from Journalism Theories, Critical Discourse Studies and Queer Studies, reflect on the possibilities of discursive change, therefore social changes, about transgenderity and, necessary- simultaneously, cisgenderity.
Udemba, Angela. "Towards the development of caspase-3/7 inhibitor(s) for in vivo PET imaging of cancer apoptosis." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/28575.
Full textPEZZOLA, SILVIA. "Glutatione s-trasferasi p1-1 come possibile bersaglio per lo sviluppo di nuovi chemioterapici: un approccio bivalente." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1220.
Full textIn this experimental work the mechanism of action of drugs, which have as intracellular target the Glutathion S-Transferases (GST), is investigated. GST are a family of enzymes involved in the detoxification pathway. These enzymes catalyze the conjugation of glutathione (GSH) to a wide variety of endogenous and exogenous electrophilic compounds, leading to a more soluble species which can be easily eliminated. Furthermore, GST are endogenous modulators of proteins involved in the apoptotic pathway. From the last century, it is known that the aberrant expression of GST isozymes is correlate with tumor onset and implicated in the development of resistance toward chemotherapy agents. We used two different approaches studying GST as target for the development of new anticancer compounds. We synthesized new molecules starting from the 6-(7-nitro-2,1,3-benzossadiazol-4-ylthio)exanol (NBDHEX), a promising inhibitor of Pi and Mu classes of GSTs (GSTP1-1 and GSTM2-2), with the aim to produce compounds more soluble and specific for the GSTP1-1 (section 1). Moreover, we characterize the mechanism of action of brostallicin, which take advantage from the overexpression of GSH/GST system to lead a molecules able to bind DNA (section 2). 1. The crystallographic analysis of the active site of GSTM2-2 and GSTP1-1 reveals that the residues in the H site of both isoenzymes well stabilize the benzossadiazole ring. However in the active site of GSTP1-1 the interactions can be improved. In particular, the interaction among the nitro group, which has a negative charge when forming Ï - complex, and some residues which have a positive charges, and also between alcoholic chain of NBDHEX with the active site. Based on these evidences we will assess the effects of the substitution of the nitro group with a sulfonic one and the changing of the alcoholic chain with aromatic group variously substituted. The resulting molecules are: 6-(7- sulfo-2,1,3-benzossadiazol-4-ylthio)exanol (SBDHEX), and derivatives of the nitrobenzofurazane ring, functionalized on the lateral chain: 2759, 2766, 2760, 2868, 2871, 2872, 2874, 2875 e 2876. These compounds are less effective than NBDHEX, however we collect important information to better design new inhibitor with bezoxadiazole bone. From our studies we clarified the important of the nitro group. Infact, the nitro group make possible the interaction with the enzyme because SBDHEX does not interact with GSTP1-1 and the molecule is not able to form the Ï -complex. The benzene ring improve the selectivity towards the GSTP1-1. Finally, compounds which are more soluble (SBDHEX, 2760, 2875) have less cytotoxic effect because of they are unable to diffuse cell membrane. 2. Brostallicin is a pro-drug which take advantage of the overexpression of GSH/GST system. Based on this evidence we clarify the mechanism of action of this compound which is in clinical trial. Through different experimental approaches we can conclude that both GSTP1-1 than GSTM2-2 catalyze the reaction between brostallicin and GSH. In particular, the affinity of brostallicin is higher for GSTM2-2 and the drug is fully active at the concentration using in cancer treatment. Both isoenzyme catalyze the formation of an intermediate reactive species, which is slowly converted into the final products. This intermediate, identified as the alpha-chloroamido derivative of the GSH-brostallicin adduct, is able to alkylate DNA in a sequence-specific manner and appears to be the active form of the drug. The kinetic behavior of the reaction between brostallicin and GSH, catalyzed by GSTP1-1, has been studied in detail, and a minimum kinetic scheme that suitably describes the experimental data is provided. Overall, these data fully support and extend the findings that brostallicin could be indicated for the treatment of tumor overexpressing the pi or mu class GST.
FIORINI, Stella. "Primi studi SAR (structure activity relationship) del Neuropeptide S. Modifiche chimiche per migliorare la farmacocinetica della Nocicettina." Doctoral thesis, Università degli studi di Ferrara, 2009. http://hdl.handle.net/11392/2388726.
Full textSardonini, Laura <1979>. "Invariants estimation in nonlinear time series." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/381/1/PhDThesis-Sardonini.pdf.
Full textSardonini, Laura <1979>. "Invariants estimation in nonlinear time series." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/381/.
Full textEndrizzi, Isabella <1975>. "Clustering of variables around latent components: an application in consumer science." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/667/1/Tesi_Endrizzi_Isabella.pdf.
Full textEndrizzi, Isabella <1975>. "Clustering of variables around latent components: an application in consumer science." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/667/.
Full textProperzi, Enrico <1976>. "Genome characterization through a mathematical model of the genetic code: an analysis of the whole chromosome 1 of A. thaliana." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5164/1/Properzi_Enrico_tesi.pdf.
Full textProperzi, Enrico <1976>. "Genome characterization through a mathematical model of the genetic code: an analysis of the whole chromosome 1 of A. thaliana." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5164/.
Full textBalduzzi, Sara <1986>. "Statistical Methods for Dealing with Selective Crossover in Randomised Controlled Trials." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7252/1/Balduzzi_Sara_tesi.pdf.
Full textBanchelli, Federico <1986>. "A Recursive Partitioning Approach to Hospital Case Mix Classification." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amsdottorato.unibo.it/7776/1/Banchelli_Federico_Tesi.pdf.
Full textLorenzon, Simone <1989>. "Extreme value prediction: a computational approach." Master's Degree Thesis, Università Ca' Foscari Venezia, 2013. http://hdl.handle.net/10579/3469.
Full textToniato, Stefano <1988>. "Ristorazione e social network: Il comportamento dei ristoratori padovani." Master's Degree Thesis, Università Ca' Foscari Venezia, 2013. http://hdl.handle.net/10579/3691.
Full textZaia, Andrea <1986>. "Modellazione e disegno sperimentale per sistemi ad alta dimensionalità." Master's Degree Thesis, Università Ca' Foscari Venezia, 2014. http://hdl.handle.net/10579/4359.
Full textAndreoletti, Mattia <1993>. "Implementing Remote Sensing technologies to assess the risk of faecal bacteria contamination in the northern Adriatic shellfish-farms." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/15869.
Full textHarris, Remi Edward Herve <1993>. "A Bayesian network approach for multi-sectoral flood damage assessment and multi-scenario analysis." Master's Degree Thesis, Università Ca' Foscari Venezia, 2020. http://hdl.handle.net/10579/18195.
Full textTOCCU, Maurizio Pietro. "Statistical Functional Data Approach to Early Detection and Diagnostics. With Application to Steam Sterilizers." Doctoral thesis, Università degli studi di Bergamo, 2016. http://hdl.handle.net/10446/63630.
Full textRagazzi, Susanna. "Innovative approaches for the construction of orthogonal arrays and permutation tests in complex experimental designs." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3421682.
Full textIl presente lavoro di tesi è stato finanziato da un borsa erogata dalla Fondazione Cariparo sul progetto di ricerca intitolato “The evaluation of customer satisfaction to improve product and services by new statistical methods of Conjoint Analysis and Design of Experiments". Il lavoro si è concentrato principalmente su due aspetti pienamente pertinenti al progetto sopracitato ovvero la costruzione di Orthogonal Arrays (OAs), funzionale alla Conjoint Analysis, e lo sviluppo di nuove tecniche inferenziali nell'ambito della pianificazione degli esperimenti. Si è ritenuto pertanto di inserire come titolo della presente tesi “Innovative approaches for the construction orthogonal arrays and permutation tests in complex experimental designs" in modo sia da rispecchiare in modo puntuale i contenuti dell'elaborato di tesi sia per evidenziare quali parti del progetto iniziale sono state maggiormente approfondite. Molti sono i contributi sulle problematiche di esistenza e costruzione degli OAs, qui si propone un approccio costruttivo basato sui concetti di counting polynomial functions; dopo un lavoro di formalizzazione dei principali concetti e nozioni, si procede alla generazione di numerosi OAs considerando diverse numerosità di livelli e di forza. Particolare attenzione è posta nella costruzione di classi non isomorfe di OAs attraverso le quali si propone un metodo per l'analisi statistica di piani multifattoriali a due ed a tre livelli non replicati. Le costruzioni dei disegni nonisomorfi sono basate sui concetti di algebraic strata, evitando così la computazione in campo complesso. Per quanto concerne lo sviluppo di metodologie inferenziali non parametriche nei disegni sperimentali, si sono presi in considerazione i disegni Randomized Complete Block (RCB) ed i disegni Split-plot (SP). Per entrambi i disegni dopo una revisione critica e sistematica dei metodi inferenziali proposti in letteratura si propongono applicazioni originali dei test di permutazione. Viene considerato, per i disegni RCB , sia il caso univariato che multivariato, proponendo soluzioni basate su più fasi di combinazione dei test allo scopo di ottenere una soluzioe globale ed anche di provveddere ad una metodologia per la correzione della molteplicità dei p-value. Sono stati inoltre effettuati studi di validazione dei test al fine di confrontare il comportamento, in termini di potenza, dei test parametrici e non parametrici da letteratura con quelli proposti. Viene inoltre effettuata un'applicazione reale del metodo nell'ambito della sperimentazione di nuove possibili fragranze di un determinato detergente con quella presente attualmente sul mercato. Per i disegni SP si valutano procedure di permutazione non parametriche basate sulle simmetrie dei blocchi (SYP) e combinazioni dirette dei test parziali al fine di testare i possibili effetti dei fattori principali e delle loro interazioni. Tramite uno studio di simulazione si valutano in potenza e sotto H0 tali test, comparandoli con test noti da letteratura. Sulla base dei risultati ottenuti, possiamo affermare che i metodi proposti forniscono una valida alternativa e soluzioni effcienti per problemi di analisi nella pianificazione degli esperimenti in presenza di non normalità delle componenti d'errore, cosa del resto frequente in studi di customer satisfaction, ed in presenza di fattori bloccati.
Melegari, Alice. "Metodi per la locazione ottimale del materiale in alimentazione ad una linea di montaggio. Il caso FERRARI S. P.A." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amslaurea.unibo.it/687/.
Full textFederzoni, Luca. "Un’applicazione per la navigazione assistita e supporto decentralizzato e la sua applicazione alla biblioteca di S. Giovanni in Monte." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/16810/.
Full textJustyn, Adrian. "Sensori distribuiti in fibra ottica per il monitoraggio di compositi fibrorinforzati a matrice inorganica (FRCM) e geopolimerica (S-FRGM)." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
Find full textYanow, Stephanie Kim. "Regulation of Cdc18 and Cdt1 restricts S phase to once per cell cycle in the fission yeast Schizosaccharomyces pombe." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251716.
Full textGoularte, Marcelo Augusto Pinto Cardoso. "Avalia??o do t?ntalo ap?s tratamento de superf?cie com oxida??o por plasma eletrol?tico (PEO)." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2014. http://tede2.pucrs.br/tede2/handle/tede/1280.
Full textEvery year scientists and biomedical manufacturers bring to the market new biocompatible materials to use as prosthetic devices for the human body. Following that trend, oral implants manufactured with a Tantalum alloy started to be marketed in 2010 by a top orthopedic company. Although this metal has already been tested in dentistry and did not show satisfactory results from an experimental as well as a clinical standpoint in the past, the lack of a successful record was due to a poor comprehension of many important factors involved in the Osseointegration phenomenon. From the fixture design to the understanding of bone biology, the years of research have shown that survival and success in oral implantology is much more than the alloy can tell. And since bone histology has proved that Tantalum has a good healing response, we decided to subject this metal to a surface treatment similar to those regularly applied to Titanium fixtures. Using an especially PEO (Plasma Electrolytic Oxidation) devised protocol we have tried to evaluate the production of a surface oxidation and salt deposition on the metal surface and verify them using SEM (Scanning Electron Microscopy) and EDS (Energy Dispersive X-Ray Detector or EDX). For that matter, four groups were prepared: Group 1 non-altered Tantalum metal sheets surfaces; Group 2 Tantalum metal sheets exposed to PEO for 1 minute; Group 3 Tantalum metal sheets exposed to PEO for 3 minutes; Group 4 Tantalum metal sheets exposed to PEO for 5 minutes. The results were very satisfactory regarding salt deposition and surface modification and similar to those already seen on Titanium after anodization.
A cada ano, cientistas e empresas biom?dicas trazem ao mercado novos materiais biocompat?veis para o uso em dispositivos prot?ticos para o corpo humano. Seguindo esse prop?sito, implantes dent?rios fabricados com uma liga de T?ntalo foram introduzidos no mercado em 2010 por uma empresa l?der em produtos ortop?dicos. Embora esse metal j? tenha sido utilizado sem muito sucesso tanto do ponto de vista experimental quanto clinico, na odontologia, a falta de uma resposta satisfat?ria foi devido ? pouca compreens?o de muitos fatores importantes envolvidos no fen?meno da Osseointegra??o. Do desenho do implante ao entendimento da biologia ?ssea, os anos de pesquisas mostraram que a sobreviv?ncia e o sucesso dos implantes dent?rios s?o muito mais do que uma liga met?lica possa representar. E j? que a histologia ?ssea tem mostrado que o T?ntalo tem uma boa resposta cicatricial, n?s decidimos submeter esse metal a um tratamento superficial similar ?queles normalmente utilizados nos implantes de Tit?nio. Usando especialmente um protocolo desenvolvido para anodiza??o PEO (Oxida??o por Plasma Eletrol?tico), n?s tentamos avaliar a produ??o de oxida??o superficial e deposi??o de sais sobre a superf?cie do metal e verificamos os resultados no MEV (Microsc?pio Eletr?nico de Varredura) e o EDS (Espectroscopia por Dispers?o de Energia Raio-X). Para a pesquisa, quatro grupos foram preparados: Grupo 1 L?minas de T?ntalo n?o tratadas; Grupo 2 L?minas de T?ntalo expostas ao PEO por 1 minuto; Grupo 3 - L?minas de T?ntalo expostas ao PEO por 3 minutos; Grupo 4 - L?minas de T?ntalo expostas ao PEO por 5 minutos. Os resultados foram muito satisfat?rios ao considerar a deposi??o de sais e modifica??o superficial, muito similar ?queles j? vistos no Tit?nio depois de exposto ao processo de anodiza??o.