Academic literature on the topic 'RXRs'
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Journal articles on the topic "RXRs"
Yagishita, Naoko, Yoko Yamamoto, Tatsuya Yoshizawa, Keisuke Sekine, Yoshikatsu Uematsu, Hisashi Murayama, Yumiko Nagai, et al. "Aberrant Growth Plate Development in VDR/RXRγ Double Null Mutant Mice." Endocrinology 142, no. 12 (December 1, 2001): 5332–41. http://dx.doi.org/10.1210/endo.142.12.8544.
Full textDollé, Pascal. "Developmental expression of retinoic acid receptors (RARs)." Nuclear Receptor Signaling 7, no. 1 (January 2009): nrs.07006. http://dx.doi.org/10.1621/nrs.07006.
Full textSugawara, Akira, Naoko Sanno, Nobuyuki Takahashi, R. Yoshiyuki Osamura, and Keishi Abe. "Retinoid X Receptors in the Kidney: Their Protein Expression and Functional Significance." Endocrinology 138, no. 8 (August 1, 1997): 3175–80. http://dx.doi.org/10.1210/endo.138.8.5351.
Full textDi Martino, Orsola, Margaret Y. Ferris, Hadwiger Gayla, Haixia Niu, and John S. Welch. "Endogenous Retinoid X Receptor Ligands Act As Tumor Suppressors in MLL-AF9 Mouse Leukemia." Blood 134, Supplement_1 (November 13, 2019): 2677. http://dx.doi.org/10.1182/blood-2019-128869.
Full textRäuber, Saskia, Maximilian Fischer, Denise Messerer, Vanessa Wimmler, Kumaraswami Konda, Andrei Todica, Michael Lorenz, Anna Titova, Christian Schulz, and Tobias Weinberger. "Modulation of Rxrα Expression in Mononuclear Phagocytes Impacts on Cardiac Remodeling after Ischemia-Reperfusion Injury." Biomedicines 10, no. 6 (May 30, 2022): 1274. http://dx.doi.org/10.3390/biomedicines10061274.
Full textNegro-Vilar, A., U. Gatzemeier, R. Ramlau, S. L. Sun, R. Negro-Vilar, T. Hermann, J. K. Zhang, and Z. Dziewanowska. "Biomarker correlates of survival in NSCLC: Role of RXRβ and PPARγ in mediating bexarotene impact on patient survival." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 7227. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.7227.
Full textVernet, Nadège, Christine Dennefeld, Cécile Rochette-Egly, Mustapha Oulad-Abdelghani, Pierre Chambon, Norbert B. Ghyselinck, and Manuel Mark. "Retinoic Acid Metabolism and Signaling Pathways in the Adult and Developing Mouse Testis." Endocrinology 147, no. 1 (January 1, 2006): 96–110. http://dx.doi.org/10.1210/en.2005-0953.
Full textDavis, K. D., T. J. Berrodin, J. E. Stelmach, J. D. Winkler, and M. A. Lazar. "Endogenous retinoid X receptors can function as hormone receptors in pituitary cells." Molecular and Cellular Biology 14, no. 11 (November 1994): 7105–10. http://dx.doi.org/10.1128/mcb.14.11.7105-7110.1994.
Full textDavis, K. D., T. J. Berrodin, J. E. Stelmach, J. D. Winkler, and M. A. Lazar. "Endogenous retinoid X receptors can function as hormone receptors in pituitary cells." Molecular and Cellular Biology 14, no. 11 (November 1994): 7105–10. http://dx.doi.org/10.1128/mcb.14.11.7105.
Full textMascrez, Bénédicte, Manuel Mark, Wojciech Krezel, Valérie Dupé, Marianne LeMeur, Norbert B. Ghyselinck, and Pierre Chambon. "Differential contributions of AF-1 and AF-2 activities to the developmental functions of RXRα." Development 128, no. 11 (June 1, 2001): 2049–62. http://dx.doi.org/10.1242/dev.128.11.2049.
Full textDissertations / Theses on the topic "RXRs"
Marceau, Geoffroy. "Facteurs de transcription nucléaires (RARs, RXRs, LXRs) et membranes amniotiques : métabolisme des rétinoïdes et stratégies d'identification de nouveaux gènes cibles des rétinoïdes." Clermont-Ferrand 1, 2007. http://www.theses.fr/2007CLF1MM01.
Full textQuintas, Ameixa Maria Clara. "Regulation of RXRa gene expression in embryonic cells." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391704.
Full textGuzmán, Alerie. "RXR signalling in oligodendrocyte lineage cells." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708611.
Full textDi, Canio Ludovica. "Regulation of oligodendrocyte lineage cell function by the RXRγ nuclear receptor." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289129.
Full textKrezel, Wojciech. "Fonction du recepteur nucleaire rxr chez la souris." Université Louis Pasteur (Strasbourg) (1971-2008), 1997. http://www.theses.fr/1997STR13090.
Full textHalftermeyer, Juliane. "Rôle de RXR sur la transformation par PML-RARα." Paris 7, 2011. http://www.theses.fr/2011PA077194.
Full textAcute promyelocytic leukemia (APL) is induced in 99% of cases by a translocation t(15-17) leading to the PML-RARa fusion oncoprotein. PML-RARa acts as a transcriptional repressor, thus inducing a characteristic differentiation block of myeloid cells. In vivo, PML-RARa is always found in association with the nuclear receptor RXR (Retinoid X Receptor). Actually, RXR is an essential protein for PML-RARa driven transformation. During my thesis, I developed in vivo and ex vivo models to study the functional role of RXR in APL, both models using conditional excision of RXR in RXRaf/f, RXRbf/f, RXRg-/- mice and the Cre-ERT2/Lox System inducible by 4-OHT. In primary bone marrow cells transformed with PML-RARa, excision of RXRs induces a dramatic loss of clonogenicity and growth arrest ex vivo. I also constructed a transgenic model of PML-RARa mice, with RXRaf/f, RXRbf/f, RXRg-/-. After introduction of a constitutively active FLT3 and Cre-ERT2,1 obtained a murine APL in which I was able to excise RXRs. In vivo, loss of RXRs results in a prolongation of mice survival and elicits full differentiation of leukemic cells, similar to that induced by treatment with retinoic acid (RA), but does not degrade PML-RARa. RA treatment was previously thought to activate transcription of target genes and thus promote differentiation by converting PML-RARa from a repressor to an activator protein. However, my results support an other model in which treatment-induced differentiation is promoted by the mere derepression of PML-RARa target genes. Further studies are needed to evaluate the DNA binding of PML-RARa in presence or absence of RXR in order to verify this hypothesis
Ma, Xingjie. "Identification d'un nouveau régulateur et d'une nouvelle fonction de la sénescence cellulaire." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1138.
Full textCellular senescence is a stable proliferation arrest accompanied with senescence-associated secretory phenotype (SASP). Senescence is induced by diverse stimuli such as telomere shortening and oncogene activation and plays key roles in many physiopathological contexts like embryonic development, cancer and aging. However the molecular mechanisms regulating senescence remain partially understood. Our laboratory recently identified a new senescence regulator: the inositol 1,4,5-trisphosphate receptor type 2 (ITPR2), an ER calcium release channel. ITPR2 is repressed in many cancers, but its transcriptional regulation is barely known. Therefore, the first aim of my thesis was to characterize new ITPR2 regulators. Through siRNA screen and Nanostring analysis, we identified the nuclear receptor RXRA as a transcriptional repressor of ITPR2. We found that in primary human fibroblasts, RXRA knockdown induces ITPR2 expression and thereby calcium signaling, reactive oxygen species (ROS) production, DNA damage and ultimately senescence through p53-p21 axis. Conversely, RXRA overexpression delays replicative senescence. SASP has been described to induce/reinforce senescence, and most of the SASP factors are able to regulate calcium signaling through their receptors. The second aim of my thesis was to investigate the role of the SASP and the participation of calcium signaling in it. We observed that the SASP induces senescence accompanied with a neuroendocrine differentiation (NED) in some breast cancer cells. Interestingly, SASP triggers calcium accumulation in the cytoplasm which seems to be involved in the regulation of NED. We then analyzed human breast tumor datasets and observed that NED-positive samples display some senescence marks: functional p53, low proliferation level and Sprouty 2 expression. Altogether, my work identified RXRA as a new senescence regulator and showed calcium signaling is involved in SASP-induced NED in breast cancer cells
Dias, Sandra Martha Gomes. "Estudos estruturais dos receptores nucleares humanos para os hormônios tireoidianos Isoforma ß1 (hTRß1) e para o ácido retinóico 9-cis Isoforma a (hRXRa)." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-21092007-141432/.
Full textIn eukaryotes, nuclear receptors are of major importance for intercellular signaling because they join different intra and extracellular signals during regulation of genetic programs. The great majority of these proteins function as ligand activated transcription factors providing a direct link between signaling molecules and the transcriptional responses elicited by them. The genetic programs that these receptors establish or modify affect virtually all aspects of the multicellular organisms? life, such as embryogenesis, homeostasis, reproduction, cell growth, and death. Their gene-regulatory power and selectivity has prompted intense research which is now starting to decipher the complex network of molecular events involved in transcription regulation. The future challenge will be to uncover the molecular rules that define spatial and temporal control of gene expression. Such knowledge would be essential to the development of more efficient drugs with better therapeutic values. Therefore, the main purpose in this study was to extend the understanding on the behavior and the structure of human thyroid receptor, isoform ?1 (hTRβ1), and human retinoic acid X receptor, isoform ? (hRXRα). It was applied the small angle X-ray scattering technique to determine, in solution, the envelop of both receptors containing DNA and ligand binding domains. Beside this, several crystallization conditions were tried for both receptors. The results made possible to define the spatial localization of the domains and the quaternary structure of the homodimers and homotetramers. Consequently, we were able to propose the first structural models for nuclear receptors containing the DNA and ligand binding domains. The oligomeric behavior of the hTRβ1, in solution, was also analyzed qualitatively. We verified that it was influenced by the presence of T3 hormone, the protein concentration, the presence of both DNA and ligand binding domains, and by specific mutations. Based on these results, we were able to hypothesize that the hTRβ1 has the capacity of autorepression. Up to now, only the hRXRα, in the whole nuclear receptor superfamily, had been described to behave similarly. Finally, we crystallized the ligand binding domain of the hTRβ1 in the presence of the ligands T3, Triac, and GC-1. The objective was to solve crystallographic structures essential for the future development of tiromimetics with isoform-selective action.
Alsudais, Hamood. "Activation of the Retinoid X Receptor Augments the Expression of Akt2 to Enhance Myogenic Differentiation." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/33395.
Full textDelman, Emily. "Effects of Synthetic Ligands onHeterodimer Pairs Regarding Full-Length Human PPARa, RXRa and LXRa." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1472204976.
Full textBooks on the topic "RXRs"
Lorna, Lawrence, ed. Thresholds to thriving: A power pack of practical Rx's. Napa, Calif: Realizations Inc., 1995.
Find full textWexler, Phillip S. The quest for service quality: Rxs for achieving excellence. Sandy, Utah: Maxcomm Associates, 1993.
Find full textShoemark, Pete. Yamaha RS/RXS 100 & 125 singles owners workshop manual. Sparkford: Haynes, 1992.
Find full textHoward, Eisenberg, ed. It's never too late to date: Shirley and Howard's Rx's for dating and mating after 50. New York: ASJA Press, 2009.
Find full textAtencio, Luis, and Paul P. Daniels. RxJS in Action. Manning Publications, 2017.
Find full textDaniels, Paul, and Luis Atencio. RxJS in Action. Manning Publications Co. LLC, 2017.
Find full textRescuing American health care: Market Rx's. Washington, DC: The Foundation, 1991.
Find full textReactive programming with RxJS: Untangle your asynchronous Javascript code. 2015.
Find full textReactive Patterns with RxJS for Angular: A Practical Guide to Managing Your Angular Application's Data Reactively and Efficiently Using RxJS 7. Packt Publishing, Limited, 2022.
Find full textReactive Programming with RxJS 5: Untangle Your Asynchronous JavaScript Code. Pragmatic Bookshelf, 2018.
Find full textBook chapters on the topic "RXRs"
Gilardi, Federica, and Béatrice Desvergne. "RXRs: Collegial Partners." In Subcellular Biochemistry, 75–102. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9050-5_5.
Full textAllegretto, Elizabeth A. "Detection of RARs and RXRs in Cells and Tissues Using Specific Ligand-Binding Assays and Ligand-Binding lmmunoprecipitation Techniques." In Retinoid Protocols, 219–32. Totowa, NJ: Humana Press, 1998. http://dx.doi.org/10.1385/0-89603-438-0:219.
Full textTauler Riera, Pedro, Maurizio Volterrani, Ferdinando Iellamo, Francesco Fallo, Andrea Ermolao, William J. Kraemer, Nicholas A. Ratamess, Avery Faigenbaum, Andrew Philp, and Keith Baar. "RXR." In Encyclopedia of Exercise Medicine in Health and Disease, 774. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2989.
Full textClow, Mark. "RxJS with Angular." In Angular 5 Projects, 309–13. Berkeley, CA: Apress, 2018. http://dx.doi.org/10.1007/978-1-4842-3279-8_17.
Full textClow, Mark. "Observers, Reactive Programming, and RxJS." In Angular 5 Projects, 291–307. Berkeley, CA: Apress, 2018. http://dx.doi.org/10.1007/978-1-4842-3279-8_16.
Full textMey, Jörg. "RAR/RXR-Mediated Signaling." In Gene Regulation, Epigenetics and Hormone Signaling, 457–510. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2017. http://dx.doi.org/10.1002/9783527697274.ch16.
Full textLarsen, Henrik, Gijs van der Hoorn, and Andrzej Wąsowski. "Reactive Programming of Robots with RxROS." In Studies in Computational Intelligence, 55–83. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-75472-3_2.
Full textBarsony, Julia. "VDR and RXR Subcellular Trafficking." In Vitamin D, 153–73. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60327-303-9_6.
Full textTroć, R. "NpS: Resonant X-ray Magnetic Scattering (RXMS)." In Actinide Monochalcogenides, 651–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-47043-4_116.
Full textGarcía Ruiz, Joaquín. "Local Geometry by XANES and RXS." In Springer Proceedings in Physics, 345–50. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-73811-6_22.
Full textConference papers on the topic "RXRs"
Lotfi, Atieh, and Rajesh K. Gupta. "RxRE." In FPGA '17: The 2017 ACM/SIGDA International Symposium on Field-Programmable Gate Arrays. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3020078.3021797.
Full textZhao, Tian, and Yonglun Li. "Semantics of RxJS." In REBLS '22: 9th ACM SIGPLAN International Workshop on Reactive and Event-Based Languages and Systems. New York, NY, USA: ACM, 2022. http://dx.doi.org/10.1145/3563837.3568340.
Full textAlabor, Manuel, and Markus Stolze. "Debugging of RxJS-based applications." In SPLASH '20: Conference on Systems, Programming, Languages, and Applications, Software for Humanity. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3427763.3428313.
Full textGoldstein, Jonathan T., Craig Strathdee, Fujiko Duke, Juliann Shih, and Matthew Meyerson. "Abstract 3627: Validation of PPARG and RXRA as drivers of bladder cancer." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3627.
Full textSakai, Hiroyasu, Yohei Shirakami, and Masahito Shimizu. "Abstract 4052: The role of the phosphorylated RXRα on diethylnitrosamine-induced liver tumorigenesis in mice." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4052.
Full textDeng, Kaiyuan. "Research on Customer Satisfaction of Logistics Enterprises based on SPSS-Beijing RXRH Customs Co., Ltd." In The International Conference on Big Data Economy and Digital Management. SCITEPRESS - Science and Technology Publications, 2022. http://dx.doi.org/10.5220/0011155200003440.
Full textSakai, Hiroyasu, Yohei Shirakami, and Masahito Shimizu. "Abstract 2709: The role of the phosphorylated RXRα on cellular proliferation and liver tumorigenesis in mice." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2709.
Full textMorris, Jay, Vondina R. Brown, Kathleen V. Coleman, and Michal J. Wargovich. "Abstract A194: Epigenetic modification of RXRα in human colon carcinomas by the green tea polyphenol, EGCG." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-a194.
Full textKaneko, Yuhei, Maki Okube, Satoshi Sasaki, R. Garrett, I. Gentle, K. Nugent, and S. Wilkins. "Estimation of the Magnetic Electron-Density Distribution by RXMS at the Electronic Transition in Absorption Edge." In SRI 2009, 10TH INTERNATIONAL CONFERENCE ON RADIATION INSTRUMENTATION. AIP, 2010. http://dx.doi.org/10.1063/1.3463357.
Full textCabang, April B., Jay L. Morris, and Michael J. Wargovich. "Abstract A03: Determining the role of Vitamin D Receptor (VDR) and Retinoid X Receptor Alpha (RXRα) in colitis." In Abstracts: AACR Special Conference: Colorectal Cancer: From Initiation to Outcomes; September 17-20, 2016; Tampa, FL. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.crc16-a03.
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