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Dissertations / Theses on the topic 'RVS AS TOOL'

Author: Grafiati

Published: 11 September 2023

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1

JHA, SALIL. "RISK EVALUATION OF EXISTING BUILDINGS USING RVS AS TOOL." Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18842.

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As per the studies conducted in past, it has been stipulated that it is not the earthquakes which kill humans, instead it is the poor and substandard practices involved in the construction of building which leads to its failure in the seismic event. Although, various IS codes for the design of building are available, but due to the rapid urbanization they have been overlooked. Being a seismic zone IV (as Per IS 1893:2016) and a rapidly urbanizing city without considering the standard construction practices, Delhi becomes a soft target for any severe seismic event. Hence, in order to safe

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2

Voss, Björn. "Advanced tools for RNA secondary structure analysis." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=97446547X.

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Pordel, Mostafa, and Thomas Hellström. "Robotics architecture frameworks, available tools and further requirements." Umeå universitet, Institutionen för datavetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-71438.

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For every robotics project, choosing a suitable framework and middleware for software and hardware is a challenging task which may influence the entire project. Robotics applications typically are resource constrained when it comes to computations and memory usage. They are built on different hardware platforms and applied in different domains. Therefore it is hard to introduce a common framework for all types of projects. However, in recent years several new attempts have been made and received attention from both researchers and industry. These frameworks are still under development and need

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4

Ding, Yindi. "Peptide aptamers : tools for the analysis of RAS signaling." Lyon, École normale supérieure (sciences), 2009. http://www.theses.fr/2009ENSL0535.

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Cette thèse décrit l'utilisation d'aptamères peptidiques (PA) comme outil d'étude de la signalisation de Ras dans des modèles de lignées cellulaires. Elle décrit ensuite les analyses initiales de l'effet biologique de petites molécules sélectionnées pour leur capacité à inhiber l'interaction entre PAs et H-RasV12. Finalement elle présente la caractérisation de précurseurs de neurones de DRG et que nous espérons pouvoir utiliser pour de futures études. Afin d'analyser les interactions entre Ras et différentes protéines et les perturbations de la voie de signalisation, PAs dirigés contre la prot

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Lang, Richard. "Regional Development Tool-Box: Leitfaden zur Unterstützung von Geschäftsideen durch regionale Vernetzung." WU Vienna University of Economics and Business, 2008. http://epub.wu.ac.at/2938/1/research_report_Toolbox.pdf.

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Chaiwatpongsakorn, Supranee. "Soluble Respiratory Syncytial Virus Fusion Protein in the Fully Cleaved, Pretriggered State, a Tool to Study Protein Triggering." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1307730650.

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7

Ljung, Marcus, and Per Turner. "CAN Tool for Atlas Copco’s Rig Control System." Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-29978.

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The goal of this 15 hp thesis in computer engineering was to develop a tool for monitoring and analyzing the data flow on a Controller Area Network (CAN) called Rig Control System (RCS) that is used by Atlas Copco. Atlas Copco develops and manufactures machines for Mining and Rock Excavation. The Rocktec division is responsible for the Rig Control System platform used on machines in all division within the Mining and Rock Excavation Technique (MR) business area. The tool’s primary purpose is monitor and analyze data from the RCS network and present the analyzed data in an easy way to help with

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Murawski, Matthew R. "Respiratory Syncytial Virus (RSV) Induces Innate Immunity through Toll-Like Receptors and Acquired Immunity via the RSV G Protein: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/432.

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Respiratory syncytial virus (RSV) causes a common infection that is associated with a range of respiratory illnesses from common cold-like symptoms to serious lower respiratory tract illnesses such as pneumonia and bronchiolitis. RSV is the single most important cause of serious lower respiratory tract illness in children < 1 year of age. Host innate and acquired immune responses activated following RSV infection have been suspected as contributing to RSV disease. Toll-like receptors (TLRs) activate innate and acquired immunity and are candidates for playing key roles in the host immune respon

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9

Shihab, Mahmud. "Web 2.0 Tools Improve Teaching and Collaboration in High School English Language Classes." NSUWorks, 2008. http://nsuworks.nova.edu/gscis_etd/303.

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Web 2.0 tools, namely blogs, wikis, podcasts, and RSS were introduced to change teaching practices of in-service high school teachers to improve the collaboration of today's students in the English language classroom. Two high school teachers of English language and their classes participated. The teachers were interviewed about their current teaching practices and provided with training to develop teaching units that use Web 2.0 to engage students as active collaborators in their learning. They integrated blogs, podcasts, wikis, and RSS into their teaching. Additional interviews were conducte

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Eriksson, Gustav, and Johan Isendahl. "Conceptual decision support tool for RMS-investments : A three-pronged approach to investments with focus on performance metrics for reconfigurability." Thesis, Tekniska Högskolan, Jönköping University, JTH, Produktionsutveckling, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-49773.

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Today's society is characterized by a high degree of change where the manufacturing systems are affected by both internal and external factors. To adapt to current manufacturing requirements in the form of short lead-time, more variants, low and fluctuating volumes, in a cost-efficient manner, new approaches are needed. As the global market and its uncertainties for products and its lifecycles change, a concept called 'reconfigurable manufacturing system' has been developed. The idea is to design a manufacturing system for rapid structural change in both hardware and software to be responsive

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11

Carlson, Megan L. "Using HAZUS-MH flood model as a floodplain management tool: Evaluation of river engineering effects on flood losses for the Middle Mississippi River." OpenSIUC, 2010. https://opensiuc.lib.siu.edu/theses/322.

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By combining FEMA's HAZUS-MH (Hazards U.S. Multi-Hazard) flood-loss estimation software and the HEC-RAS hydraulic modeling package, this study was able to quantify potential beneficial and adverse impacts of flood-control and navigational structures along the Middle Mississippi River (MMR; between Mississippi-Missouri River confluence and Thebes, IL). The goal of this investigation was to assess changes in water-surface elevations and associated flood losses to: 1) quantify the potential exposure of flooding under different flood-control configurations along the Middle Mississippi River (MMR),

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Beal, Quincy Frodesen. "Manager Tools Podcast: A Study of Podcasting's Effectiveness with Profit Potential." Diss., CLICK HERE for online access, 2008. http://contentdm.lib.byu.edu/ETD/image/etd2718.pdf.

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13

Bhushan, Sudhanshu. "Uropathogenic Escherichia coli block MyD88 dependent and activate MyD88 independent signaling pathways in rat testicular cells /." Giessen : VVB Laufersweiler, 2008. http://d-nb.info/992792584/04.

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Neiß, (Neiss) Michael, B. Sholts Sabrina, and Sebastian K. T. S. Wärmländer. "3D laser scanning as a tool for Viking Age studies." Uppsala universitet, Institutionen för arkeologi och antik historia, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-180568.

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Three-dimensional (3D) laser scanners are becoming increasingly more affordable and user-friendly, making 3D-modeling tools more widely available to researchers in various countries and disciplines. In archaeology, 3D-modeling has the particular advantages of facilitating the documentation and analysis of objects that are fragile, rare, and often difficult to access. We have previously shown that 3D-modeling is a highly useful tool for shape analysis of archaeological bone material, due to the high measurement accuracy inherent in the latest generation of 3D laser scanners (Sholts et al. 2010;

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Le, Corf Katy. "La dualité fonctionnelle de la protéine MyD88, dans la signalisation Ras/MAPKs et l'inflammation, conduit à la transformation cellulaire." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10121.

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MyD88 est une protéine adaptatrice du système immunitaire inné, impliquée dans la défense de l’organisme contre les agents microbiens. Elle est recrutée aux « Toll-like receptors » (TLRs) suite à la reconnaissance par ces derniers de motifs microbiens conservés, les PAMPs (Pathogens-associated molecular patterns). La voie de signalisation ainsi déclenchée va aboutir à la production de cytokines pro-inflammatoires, de chimiokines et d’espèces actives de l’oxygène. De cette façon, les TLRs, via MyD88, constituent la première ligne de défense contre les pathogènes.De nombreuses études ont permis

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Serena, Lacerenza. "Proteomics as a tool to investigate ROS-related pathologies: new putative biomarkers for malignant pleural mesothelioma and neuroprotective mechanisms of oleocanthal in neurodegenerative diseases." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1073196.

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Oxidative stress contributes to the development and progression of a broad range of syndromes and diseases, especially cancer and neurodegenerative processes. Malignant pleural mesothelioma (MPM) is a highly aggressive tumor originating from the mesothelial cells of the pleura, associated with asbestos exposure. Inhalation of long and thin asbestos fibers induces a chronic inflammatory response at sites of fibers deposition, with accumulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) that over time may lead to malignant cell transformation. MPM is characterized by a

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Löfgren, J. (Johan). "Genetic polymorphisms in collectins and Toll-like receptor 4 as factors influencing susceptibility to severe RSV infections and otitis media." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514290671.

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Abstract Respiratory syncytial virus (RSV) is one of the most common pathogens for early childhood respiratory tract infections. Most children are infected by RSV, approximately 1% of infants require hospital care. RSV infections are often accompanied by otitis media (OM). Surfactant proteins A and D (SP-A and SP-D) are involved in lung function and innate immunity. The proteins are capable of recognizing surface patterns in pathogens and function as a defense before the acquired immunity is developed. The Toll-like receptor (TLR) family is associated to several pathogens. The role of the TLR-

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18

Hamza, Kankia Ibrahim. "Design and development of novel tools for the screening and identification of inhibitors of HER receptor family and NFR2 for ovarian cancer therapy." Thesis, Abertay University, 2017. https://rke.abertay.ac.uk/en/studentTheses/441e2039-1bde-448b-9c87-d2845ac1da96.

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Cancer, which is characterised by aggressiveness and increased capacity for metastatic spread still requires basic researchers and clinicians to direct enormous efforts toward the development of novel therapeutic targets. Potential novel targets can be identified and exploited in combination with currently existing therapeutic approaches to improve their efficacy and overcome treatment resistance of tumour cells, protecting the patient from recurrence. To achieve this, different strategies and techniques can be proposed to identify the most promising candidate molecules for further exploitatio

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Eccher, Giulia. "Setting up of molecular tools for studying abscission in apple (Malus x domestica)." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427507.

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Abscission is a natural self-regulatory mechanism whereby fruit trees shed part of the fruitlets, and is an important agricultural event from the farmer’s point of view because it directly affects the final size and quality of the commodity. In spite of this self-regulatory mechanism, fruit trees set too many fruitlets negatively affecting not only the final quality, but also the returning bloom. To avoid these effects, farmers perform blossom or fruitlet thinning to adjust crop load and ensure a satisfactory fruit quality at harvest for commercial purposes. Chemical thinning is nowadays a com

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Teichert, Ernest J. "Forging peace together : building partnership capacity as an important tool for international security and stability /." Maxwell AFB, Ala. : School of Advanced Air and Space Studies, 2008. https://www.afresearch.org/skins/rims/display.aspx?moduleid=be0e99f3-fc56-4ccb-8dfe-670c0822a153&mode=user&action=downloadpaper&objectid=75704185-dd3b-4790-826a-51df5fdbf14c&rs=PublishedSearch.

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21

Patrick-Melin, Amy J. "Effect of 7 Days Aerobic Exercise on Insulin Sensitivity, Oxidative Stress, TLR2/TLR4 Cell Surface Expression and Cytokine Secretion in Sedentary Obese Adults." Kent State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=kent1310918543.

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22

Andrade, Warrison Athanasio Coelho de. "Caracterização parcial e localização subcelular de um fator de troca de nucleotídeos guanina associado à proteína Ras (RasGEF1b) induzido por agonistas de receptores do tipo Toll." Universidade Federal de Minas Gerais, 2008. http://hdl.handle.net/1843/BUOS-9AUG25.

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The guanine nucleotide exchange factors of the Ras protein super family (RasGEFs) are essential cellular components in the process of Ras activation in response to diverse extra cellular stimuli. The rasGEF1b is a highly conserved guanine exchange factor (GEF). In macrophages expression of rasGEF1b mRNA is induced by different TLRs agonists, such as LPS (TLR4), GPImucin (TLR2) and Poli I: C (TLR3). First, by using bioinformatics tolls we analyzed the probable RasGEF1b subcellular localization. The pFLAGCMV2 encoding the recombinant protein FLAGRasGEF1b was used to transfect HEK 293T cells and

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23

Roda, GIlabert Xavier. "Estudio de las actividades de percusión de los grupos cazadores recolectores del noreste peninsular a inicios del holoceno. El asentamiento al aire libre de font del ros (Berga, Barcelona)." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669397.

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El instrumental relacionado con las actividades domésticas de los cazadores- recolectores es un aspecto al que tradicionalmente se le ha prestado escasa atención. Este exiguo conocimiento me motivó a analizar cantos y fragmentos, un componente habitual pero poco descrito en la mayoría de contextos arqueológicos. Esta conjunto de materiales líticos no tallados se ha denominado comúnmente como instrumental macrolítico o ground stone tools. La presente tesis doctoral aborda el estudio del comportamiento de los últimos grupos cazadores recolectores en un contexto estratigráfico al aire libre. La

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24

Ekeh, Peter Nnamdi. "Survey on nail discoloration and association with CD4 count among untreated HIV patients at Apin Centre, Nigeria." Thesis, University of the Western Cape, 2010. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_4320_1362393499.

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<p>Eligibility for antiretroviral therapy (ART) in HIV-infected patients is defined either by a cluster of differentiation antigen 4 (CD4) count of less than 200cells/mm3 or clinical diagnosis of WHO stage III and IV. Therefore, the decision to start ART becomes difficult when CD4 cell count is not available. With limited laboratory infrastructure, the decision to start ART is usually made based on clinical symptoms leading to late commencement of ART. This calls for alternative criteria to see if nail discoloration (ND) correlates with low CD4 count among untreated HIV infected patients. This

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Ciappuccini, Renaud. "Apport de l'imagerie fonctionnelle par TEMP/TDM et TEP/TDM dans la prise en charge des cancers différenciés de la thyroïde Incremental Value of a Dedicated Head and Neck Acquisition during 18F-FDG PET/CT in Patients with Differentiated Thyroid Cancer Full text links full-text provider logo Actions Favorites Share Page navigation Title & authors Abstract Conflict of interest statement Figures Similar articles Cited by References Related information LinkOut - more resources EJNMMI Res . 2018 Dec 3;8(1):104. doi: 10.1186/s13550-018-0461-x. Optimization of a dedicated protocol using a small-voxel PSF reconstruction for head-and-neck 18 FDG PET/CT imaging in differentiated thyroid cancer 78 Lymph node involvement in head-and-neck and thyroid cancers with digital PET/CT: the impact of ultra-high definition voxels and point-spread function Tumor burden of persistent disease in patients with differentiated thyroid cancer: correlation with postoperative risk-stratification and impact on outcome 133 18F-Fluorocholine PET/CT is a highly sensitive but poorly specific tool for identifying malignancy in thyroid nodules with indeterminate cytology: The Chocolate study PSMA expression in neovasculature of persistent/recurrent differentiated thyroid cancerin the neck: relationship with radioiodine uptake, 18Fluorodeoxyglucose avidity and outcome." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC424.

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L’imagerie scintigraphique des cancers thyroïdiens différenciés (CTD) présente la particularité d’utiliser deux radiopharmaceutiques, l’iode 131 (131I) et le 18-Fluorodésoxyglucose (18FDG). La fixation de ces traceurs dépend habituellement du degré de différenciation et de l’agressivité de la tumeur. L’objectif de ce travail était d’étudier l’apport de différents aspects techniques et d’instrumentation, à savoir l’imagerie hybride par TEMP/TDM et TEP/TDM, la point-spread function (PSF), la taille des voxels et la technologie TEP digitale, et d’explorer si d’autres traceurs TEP pouvaient présen

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Vu, Xuan Nghia. "Generation of tools to investigate Chikungunya virus." Doctoral thesis, 2008. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-28993.

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CHIKV is the prototype of Alphaviruses and it causes an acute febrile illness with rash, severely painful arthralgias, and sometimes arthritis. While CHIKV has first been identified in the 1950s in Africa, recent outbreaks of CHIKV in the islands of the Indian Ocean and particular in Italia have re-drawn attention to CHIKV. In the past CHIKV disease was considered self-limiting and non-fatal. However, a number of deaths on Reunion (Anonym, 2006) during the outbreak, which was affected directly or indirectly by CHIKV, have changed this view. To defeat CHIKV outbreaks diagnostic tools and anti C

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Brito, Ana Sofia da Costa e. "Saccharomyces cerevisiae strains expressing human KRAS as tools for targeting therapeutic anti-EGFR-RAS pathway antibody - drugs." Master's thesis, 2015. http://hdl.handle.net/1822/35686.

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Dissertação de mestrado em Genética Molecular<br>Fundamental cellular processes appear to be highly conserved between Saccharomyces cerevisiae and other more complex Eukaryotic species, including humans. “Humanized yeast systems” emerged as a tool to study molecular aspects of human pathologies. The present work aimed at contributing to build and validate a large high throughput platform of yeast strains displaying phenotypes that can enable further testing galectin-related drugs and peptides. This platform was designed to consist of two types of strains, the ones expressing human galecti

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Erdmann, Matthias. "Magneto-microphotoluminescence spectroscopy as a tool for the study of disorder in semiconductor quantum wells." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-0006-B456-6.

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Mezger, Markus. "Interaktion zwischen dem humanen Cytomegalievirus, Aspergillus fumigatus, dendritischen Zellen und neutrophilen Granulozyten." Doctoral thesis, 2007. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-27254.

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Immunsupprimierte Patienten besitzen ein erhöhtes Risiko für opportunistische Infektionen, die hauptsächlich durch das humane Cytomegalievirus (HCMV) und den Schimmelpilz Aspergillus fumigatus verursacht werden. Aufgrund ihrer Lokalisation in den Geweben unterhalb von Lungenepithelien und des Gastrointestinaltraktes werden dendritische Zellen (DCs) als diejenigen Zellen betrachtet, die während der frühen Phase einer Infektion in Kontakt mit HCMV und A. fumigatus kommen und eine Aktivierung von angeborenen und adaptiven Abwehrmechanismen vermitteln. Im Rahmen der vorliegenden Dissertation wurde

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Considine, Breandan. "Programming tools for intelligent systems." Thesis, 2020. http://hdl.handle.net/1866/24310.

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Les outils de programmation sont des programmes informatiques qui aident les humains à programmer des ordinateurs. Les outils sont de toutes formes et tailles, par exemple les éditeurs, les compilateurs, les débogueurs et les profileurs. Chacun de ces outils facilite une tâche principale dans le flux de travail de programmation qui consomme des ressources cognitives lorsqu’il est effectué manuellement. Dans cette thèse, nous explorons plusieurs outils qui facilitent le processus de construction de systèmes intelligents et qui réduisent l’effort cognitif requis pour concevoir, développer, teste

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Μπέσσα, Σωτηρία. "Ημιαυτόματες διαδικασίες συλλογής και σύνθεσης πληροφορίας από ιστοσελίδες και Web 2.0 εκπαιδευτικές συνιστώσες. Μελέτη και εφαρμογή τους στα πλαίσια υλοποίησης της πύλης WEP". Thesis, 2008. http://nemertes.lis.upatras.gr/jspui/handle/10889/965.

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Η εργασία αυτή αποτελεί συνέχεια μιας προσπάθειας για την ανάπτυξη της πύλης WEP (Web Engineering Resources Portal). Πρόκειται για ένα Μοντέλο Αναφοράς και μια Πύλη Πόρων που φιλοδοξεί να αποτελέσει ένα σημαντικό εργαλείο για το web engineering, αλλά και αναφορά στην ανάπτυξη εφαρμογών / πληροφοριακών συστημάτων παγκοσμίου ιστού και οδηγό στην ανεύρεση και κατανόηση τεχνολογιών και εργαλείων. Το κομμάτι με το οποίο θα ασχοληθούμε εδώ αφορά το τελευταίο μέρος και τον εκπαιδευτικό χαρακτήρα που επιθυμούμε να προσδώσουμε στην πύλη. Συνοπτικά, η διπλωματική εργασία κινείται σε τρεις άξονες: Πρώ

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Lokesh, N. "Pushing the Limits of NMR Sensitivity and Chiral Analysis : Design of New NMR Methods and Bio-Molecular Tools." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3842.

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The thesis entitled "Pushing the Limits of NMR Sensitivity and Chiral Analysis: Design of New NMR Methods and Bio-molecular Tools" consists of six chapters. The research work reported in this thesis is focused on the development of novel chemical and NMR methodological approaches for enantiomeric analysis and mea- surement of residual dipolar couplings (RDCs), and the development of sensitivity enhanced slice selective NMR experiments for obtaining pure shift 1H spectra and the measurement of scalar couplings. The thesis is divided into two parts. The Part I comprises chapters 2-4, where

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Lokesh, N. "Pushing the Limits of NMR Sensitivity and Chiral Analysis : Design of New NMR Methods and Bio-Molecular Tools." Thesis, 2015. http://etd.iisc.ernet.in/2005/3842.

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The thesis entitled "Pushing the Limits of NMR Sensitivity and Chiral Analysis: Design of New NMR Methods and Bio-molecular Tools" consists of six chapters. The research work reported in this thesis is focused on the development of novel chemical and NMR methodological approaches for enantiomeric analysis and mea- surement of residual dipolar couplings (RDCs), and the development of sensitivity enhanced slice selective NMR experiments for obtaining pure shift 1H spectra and the measurement of scalar couplings. The thesis is divided into two parts. The Part I comprises chapters 2-4, where

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Suresh, B. G. "RLtools : A Toolset For Visual Language Application Development Based on Relational Grammars." Thesis, 1997. https://etd.iisc.ac.in/handle/2005/1804.

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Suresh, B. G. "RLtools : A Toolset For Visual Language Application Development Based on Relational Grammars." Thesis, 1997. http://etd.iisc.ernet.in/handle/2005/1804.

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Jundi, Malek. "Le rôle du CD40 homodimère dans la réponse immunitaire." Thèse, 2013. http://hdl.handle.net/1866/10869.

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Le CD40 est une glycoprotéine transmembranaire de type I, appartenant à la famille des TNFRs, exprimée à la surface des cellules immunitaires, hématopoïétiques, vasculaires, épithéliales, et d’autres types de cellules, y compris les cellules tumorales. Le CD40 ne possédant pas de domaine kinase, pour induire un signal il interagit directement ou indirectement avec des protéines adaptatrices telles que les TRAFs et les JAKs. L’interaction du CD40 avec son principal ligand, le CD154, joue un rôle primordial dans la régulation de la réponse immunitaire et le maintien de l’homéostasie. L’activatio

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Προδρομίδης, Γεώργιος. "Mathematical simulation and optimization of a stand alone zero emissions hybrid system based on renewable energy sources." Thesis, 2014. http://hdl.handle.net/10889/7938.

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Renewable Energy Sources (RES) are the most promising resources of energy production for everyday life. Therefore, the precise combination of RES based technologies into hybrid systems could provide the solution to several energy problems facing the planet. The motivation of the present research study is the total understanding of the prevailing phenomena by using RES equipment in several projects. This thesis will focus on standalone hybrid RES based systems. By presenting the RES systems the necessity of buffering systems will become apparent as the most crucial parts of off-grid systems. T

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Tomic, Jelena. "Aberrations in Cytokine Signaling in Leukemia: Variations in Phosphorylation and O-GlcNAcylation." Thesis, 2012. http://hdl.handle.net/1807/32829.

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Tumor-induced immunosuppression can occur by multiple mechanisms, each posing a significant obstacle to immunotherapy. Evidence presented in this dissertation suggests that aberrant cytokine signaling, as a result of altered metabolism of Chronic Lymphocytic Leukemia (CLL) cells, confers a selective advantage for tumor survival and growth. Cells from CLL patients with aggressive disease (as indicated by high-risk cytogenetics) were found to exhibit prolongation in Interferon (IFN)-induced STAT3 phosphorylation, and increased levels of reactive oxygen species (ROS) in these cells reflected th

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