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Published: 27 July 2024
Last updated: 29 July 2024

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1

Krupat, Arnold. "Honoring LaVonne Ruoff." Studies in American Indian Literatures 17, no. 2 (2005): 96–97. http://dx.doi.org/10.1353/ail.2005.0052.

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2

Regier, Willis Goth. "Rough Ruoff, Pirate Fighter." Studies in American Indian Literatures 17, no. 2 (2005): 100. http://dx.doi.org/10.1353/ail.2005.0057.

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3

Lippit, Akira. ": The Emperor's Naked Army Marches on: Yukiyukite shingun . Jeffrey Ruoff, Kenneth Ruoff." Film Quarterly 53, no. 3 (April 2000): 58. http://dx.doi.org/10.1525/fq.2000.53.3.04a00130.

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4

Marks, Laura U. "The Emperor’s Naked Army Marches on (Yukiyukite Shingun) Jeffrey Ruoff and Kenneth Ruoff." Canadian Journal of Film Studies 9, no. 1 (March 2000): 134–36. http://dx.doi.org/10.3138/cjfs.9.1.134.

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5

Savage, Neil. "A Conversation with Rodney Ruoff." ACS Central Science 5, no. 3 (March 12, 2019): 374–75. http://dx.doi.org/10.1021/acscentsci.9b00239.

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6

Bataille, Gretchen M. "Tribute to LaVonne Brown Ruoff." Studies in American Indian Literatures 17, no. 2 (2005): 75–76. http://dx.doi.org/10.1353/ail.2005.0042.

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7

Bosma, Peter. "Ruoff (ed.), Programming Film Festivals." TMG Journal for Media History 15, no. 1 (October 5, 2012): 141. http://dx.doi.org/10.18146/tmg.424.

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8

Lippit, Akira. "Review: The Emperor's Naked Army Marches on: Yukiyukite shingun by Jeffrey Ruoff, Kenneth Ruoff." Film Quarterly 53, no. 3 (2000): 58. http://dx.doi.org/10.2307/1213742.

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9

Nornes, Abé Markus. "The Emperor's Naked Army Marches On: Yukiyukite shingun. By Jeffrey Ruoff and Kenneth Ruoff. England: Flicks Books, 1998. 57 pp." Journal of Asian Studies 58, no. 2 (May 1999): 531–32. http://dx.doi.org/10.2307/2659455.

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10

Blümcke, Martin, and Gerhard W. Baur. "Rezension von: Baur, Gerhard W., Bibliographie zur Mundartforschung in Baden-Württemberg, Vorarlberg und Liechtenstein." Württembergisch Franken 67 (February 14, 2024): 231. http://dx.doi.org/10.53458/wfr.v67i.10318.

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Gerhard W. Baur: Bibliographie zur Mundartforschung in Baden-Württemberg, Vorarlberg und Liechtenstein (= Idiomatica, Veröffentlichungen der Tübinger Arbeitsstelle »Sprache in Südwestdeutschland«, 7, hrsg. von Arno Ruoff). Tübingen: Niemeyer 1978. 250 S., 9 Ktn.
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11

Lent, John A. "Jeffrey Ruoff and Kenneth Ruoff. The Emperor's Naked Army Marches On, Yukiyukite Shingun. Trowbridge, Wiltshire, UK: Flicks Books, 1998. 58 pp." Asian Cinema 10, no. 2 (March 1, 1999): 155. http://dx.doi.org/10.1386/ac.10.2.155_5.

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12

Silverman, Eric K. "Virtual Voyages: Cinema and Travel edited by Jeffrey Ruoff." American Anthropologist 112, no. 4 (November 29, 2010): 651–52. http://dx.doi.org/10.1111/j.1548-1433.2010.01288.x.

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13

Allen, Chadwick. "Grateful for the Push: A Tribute to LaVonne Ruoff." Studies in American Indian Literatures 17, no. 2 (2005): 71–74. http://dx.doi.org/10.1353/ail.2005.0040.

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14

Hollrah, Patrice E. M. "First Impressions of A. LaVonne Brown Ruoff as an Author." Studies in American Indian Literatures 17, no. 2 (2005): 87–88. http://dx.doi.org/10.1353/ail.2005.0050.

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15

Bühler, Rudolf. "Sprachalltag II: Sprachatlas – Digitalisierung – Nachhaltigkeit und das Arno-Ruoff-Archiv am Ludwig-Uhland-Institut für Empirische Kulturwissenschaft der Universität Tübingen." Linguistik Online 98, no. 5 (November 8, 2019): 411–23. http://dx.doi.org/10.13092/lo.98.5946.

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Since 2015, the project Sprachalltag II has been running at the Institute of Historical and Cultural Anthropology in Tübingen. In addition to the final processing of the Sprachatlas von Nord Baden-Württemberg (SNBW), begun in 2009, and the creation of a popular, online Sprechender Sprachatlas von Baden-Württemberg, the goal is to research and digitize the extensive material of the Arno-Ruoff archive for further linguistic and ethnologic studies. This project in particular includes the transcription and alignment of the dialect recordings collected by Ruoff and Bausinger since 1955 for the so called Zwirner corpus as well as the publication of the edited texts in a database in cooperation with the IDS Mannheim. After researching mainly on the morphological and syntactic level of the corpus, the project now also enables phonological examinations of the spoken language throughout the federal state of Baden-Württemberg and the area of Bavarian Swabia via the database. This report will introduce the nature and extent of the hitherto edited recordings in more detail and show how, in the sense of a cross-disciplinary collaboration, Empirical Cultural Studies can benefit from the content development of the Tübingen corpus. In the course of editing, the transcripted dialect recordings are assigned to thematic categories by using keywords such as leisure or modernization. This includes the means of enquiry of the corpus to a content-related level that can serve the research fields of Historical and Cultural Anthropology.
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16

Swaab, Peter, and Richard E. Matlak. "Wordsworth and Coleridge: The Making of the Major Lyrics 1802-1804. Gene W. Ruoff." Wordsworth Circle 21, no. 4 (September 1990): 147–51. http://dx.doi.org/10.1086/twc24042406.

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17

Gribben, Alan. "Redefining American Literary History ed. by A. LaVonne Brown Ruoff, Jerry W. Ward, Jr." Western American Literature 27, no. 2 (1992): 136–37. http://dx.doi.org/10.1353/wal.1992.0105.

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18

Heath, William. ": Wordsworth and Coleridge: The Making of the Major Lyrics, 1802-1804. . Gene W. Ruoff." Nineteenth-Century Literature 46, no. 1 (June 1991): 117–20. http://dx.doi.org/10.1525/ncl.1991.46.1.99p0364j.

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19

Heißenbüttel, Dietrich. "Die Fritz und Hildegard Ruoff Stiftung in Nürtingen als Museum für Kunst und Literatur." Schwäbische Heimat 74, no. 3 (November 14, 2023): 15–20. http://dx.doi.org/10.53458/sh.v74i3.8452.

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20

MAO, HO-KWANG, JON H. EGGERT, and RUSSELL J. HEMLEY. "REFLECTANCE EFFECTS CAUSED BY REFRACTIVE INDEX GRADIENTS IN DIAMOND CELL SAMPLES OF H2 AND Al2O3." Modern Physics Letters B 09, no. 03n04 (February 20, 1995): 201–8. http://dx.doi.org/10.1142/s021798499500019x.

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At high pressures, optical spectroscopic techniques are the principal means for probing dense solid hydrogen, including both its vibrational and electronic excitations. Ruoff et al. [Phys. Rev.B47, 11039 (1993)] proposed that refractive index gradients of H 2 samples loaded with 5% Al 2 O 3 powder in diamond anvil cells could cause a 4% rise in infrared reflectivity which interfered with the measurements on hydrogen reported by Mao et al. [Phys. Rev. Lett.65, 484 (1990)]. We have analyzed this alternative proposal, including computer simulations of the appropriate sample configuration. Our calculations show that effects of a graded index on the rise of reflectivity from 1.0 to 0.5 eV are less than 0.1% and are therefore insignificant.
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21

WALKER, JOHN. ""Redefining American Literary History", ed. A. Lavonne Brown Ruoff and Jerry W. Ward (Book Review)." Bulletin of Hispanic Studies 69, no. 4 (October 1992): 397. http://dx.doi.org/10.3828/bhs.69.4.397c.

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22

Wetzler, Peter. "Reviews of Books:The People's Emperor: Democracy and the Japanese Monarchy, 1945-1995 Kenneth J. Ruoff." American Historical Review 108, no. 2 (April 2003): 495–96. http://dx.doi.org/10.1086/533263.

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23

Menzinger, Michael, and Peter Jankowski. "Reply to Ruoff and Noyes' comment on "Heterogeneities and stirring effects in the Belusov-Zhabotinsky reaction"." Journal of Physical Chemistry 90, no. 26 (December 1986): 6865. http://dx.doi.org/10.1021/j100284a031.

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24

Moore, David L. ""The literature of this nation": LaVonne Ruoff and the Redefinition of American Literary Studies." Studies in American Indian Literatures 17, no. 2 (2005): 63–70. http://dx.doi.org/10.1353/ail.2005.0054.

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25

Isernhagen, Hartwig. "Review: Redefining American Literary History edited by A. LaVonne Brown Ruoff and Jerry W. Ward, Jr." Explorations in Ethnic Studies ESS-12, no. 1 (August 1, 1992): 52–54. http://dx.doi.org/10.1525/ess.1992.12.1.52.

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26

Powell, Malea. ""There's still more digging to do": A Story in Honor of A. LaVonne Brown Ruoff." Studies in American Indian Literatures 17, no. 2 (2005): 5–9. http://dx.doi.org/10.1353/ail.2005.0056.

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27

CHRISTENSEN, ARNE EMIL. "The New View: Underwater Archaeology and the Historical Picture - Edited by Albert Hafner, Urs Niffeler and Ulrich Ruoff." International Journal of Nautical Archaeology 37, no. 1 (March 2008): 206–7. http://dx.doi.org/10.1111/j.1095-9270.2007.00179_11.x.

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28

Russell, John. "The Last Vaudevillian: on the road with travelogue film-maker John Holod (a non-fiction film by Jeffrey Ruoff)." Visual Communication 2, no. 1 (February 2003): 25–28. http://dx.doi.org/10.1177/1470357203002001749.

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29

Sulloway, Alison G. "Jane Austen's Novels: The Art of Clarity. Robert Gard.Jane Austen: Real and Imaginary Worlds. Oliver MacDonagh.Jane Austen's Sense and Sensibility. Gene Ruoff." Wordsworth Circle 25, no. 4 (September 1994): 229–33. http://dx.doi.org/10.1086/twc24043121.

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30

Reynolds, E. Bruce. "The People'S Emperor: Democracy and the Japanese Monarchy, 1945–1995. By Kenneth J. Ruoff. Cambridge, Ma: Harvard University Asia Center, 2001. 331 pp." Journal of East Asian Studies 3, no. 2 (August 2003): 346–47. http://dx.doi.org/10.1017/s1598240800001429.

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31

Zielinski, Ger. "Book Review: The Film Festival Reader Edited by Diana Iordanova, Coming Soon to a Festival Near You: Programming Film Festivals Edited by Jeffrey Ruoff." Film Quarterly 67, no. 3 (2014): 82–85. http://dx.doi.org/10.1525/fq.2014.67.3.82.

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32

Yamamoto, Genzo. "The People's Emperor: Democracy and the Japanese Monarchy, 1945–1995. By Kenneth J. Ruoff. Cambridge: Harvard University Press, 2001. xiv, 331 pp. $45.00 (cloth)." Journal of Asian Studies 61, no. 4 (November 2002): 1384–86. http://dx.doi.org/10.2307/3096488.

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33

Klyushnichenko, V. N. "Analysis of the principles of reference inventory today." Geodesy and Cartography 924, no. 6 (July 20, 2017): 43–48. http://dx.doi.org/10.22389/0016-7126-2017-924-6-43-48.

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A comparative analysis of the principles of the cadastre in the most developed countries and in Russia. It is shown that some of the principles of cadastre, it is advisable to introduce into the Russian legislation. Such principles include the principle of Renzenberger, as well as the principles of Ruoff and Kuranda. The Russian inventory has more than twenty years, however, it cannot be considered complete, as registered in cadastre only 60 % of real estate. Full filling of the cadastre information on real estate is possible, if we abandon the application of the principle of reference. Unlike foreign domestic inventory the inventory contains errors that complicate the procedure of registration of immovable property. In addition, the domestic inventory is not the only source of information about the property that causes the ambiguity of the information about the same object. Important is also that the damage caused inaccurate inventory information bona fide buyer or seller of real property under current law, does not exceed one million rubles, regardless of the value of the lost object. Foreign inventory recognizes the property owner the main participant of the changes, however, the Russian legislation allows for the adjustment of the information object without the application of the property owner. See principles of the foreign inventory is useful for the maintenance of the national cadastre. This will simplify the process of state cadastral accounting of real estate, reduce the time of its formation and to increase the reliability of materials of the Unified state register of real estate.
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34

Fujioka, Yuka. "Imperial Japan at Its Zenith: The Wartime Celebration of the Empire's 2600th Anniversary. By Kenneth J. Ruoff. Ithaca, NY: Cornell University Press, 2010. xv, 236 pp. $39.95 (cloth)." Journal of Asian Studies 72, no. 1 (February 2013): 205–6. http://dx.doi.org/10.1017/s0021911812002069.

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35

Paxton, Steve. "Jeffrey Ruoff, Still Moving. Pilobolus at Forty (A Film), 2012, New Boston Films, Norwich VT [at 38 minutes, both a look at 1971 archival footage and an update to 2010]." Dance Research 32, no. 2 (November 2014): 266–67. http://dx.doi.org/10.3366/drs.2014.0113.

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36

Scherer, James A. "Death Throes of a Dynasty: Letters and Diaries of Charles and Bessie Ewing, Missionaries to China. Edited by E. G. Ruoff. Kent, Ohio: Kent State University Press, 1990. 276. $29.00." Church History 62, no. 4 (December 1993): 574–75. http://dx.doi.org/10.2307/3168098.

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37

Schwentker, Wolfgang. "Kenneth J. Ruoff, Japan’s Imperial House in the Postwar Era, 1945–2019. (Harvard East Asian Monographs, Vol. 432.) Cambridge, MA und London, Harvard University Asia Center / Harvard University Press 2020." Historische Zeitschrift 315, no. 3 (December 1, 2022): 829–31. http://dx.doi.org/10.1515/hzhz-2022-1483.

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38

Cardin, David, and P. J. Smith. "Fullerenes: chemistry, physics and technology Karl M. Kadish and Rodney S. Ruoff (eds) John Wiley & Sons Inc., New York, 2000 ix?+?968 pages. �126 ISBN 0-471-29089-0." Applied Organometallic Chemistry 15, no. 7 (2001): 646–47. http://dx.doi.org/10.1002/aoc.173.

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39

Habault, Justine, Jeffrey A. Schneider, Susan Ha, Rachel Ruoff, Joseph Puccini, Dafna Bar-Sagi, Kwok-Kin Wong, et al. "Abstract 3441: A multivalent peptoid conjugate that inhibits therapy-resistant prostate cancer cell proliferation by modulating androgen receptor transcriptional activity." Cancer Research 83, no. 7_Supplement (April 4, 2023): 3441. http://dx.doi.org/10.1158/1538-7445.am2023-3441.

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Abstract Prostate cancers adapt to androgen receptor (AR) pathway inhibitors and progress to castration resistance despite the continued expression and function of the AR. We developed a new approach to antagonize the proliferative activity of AR and inhibit castration-resistant prostate cancer (CRPC) growth using multivalent peptoid conjugates (MPCs). Our strategy is to display multiple copies of the AR antagonist, ethisterone, on a peptoid scaffold. Such a multivalent display increases the ligand’s effective local concentration, thus targeting AR with high affinity and affecting AR interactions with coregulators. Here, we report a new potent MPC called MPC309, which displays three ethisterone groups and binds to AR with nanomolar affinity. MPC309 reduces the proliferation of enzalutamide-resistant prostate cancer cells, including those harboring AR splice variants, AR ligand binding mutations, and non-canonical AR gene expression programs. We provide evidence that MPC309 enters cells via macropinocytosis, which facilitates the fluid-phase uptake of extracellular macromolecules. Macropinocytotic uptake of MPC309 enhances cancer cell-specific delivery, thus limiting systemic toxicities. MPC309 displays favorable pharmacological properties and produced significantly greater tumor suppression in xenograft studies than enzalutamide, the standard of care anti-androgen in clinical use. Mechanistically, MPC309 inhibits prostate cancer growth by eliciting a unique gene expression program through alterations in AR chromatin occupancy compared to dihydrotestosterone (DHT) or enzalutamide. Thus, MPC309 represents a novel AR antagonist that activates an AR anti-proliferative program to repress the growth of CRPC and supports further investigation of the MPC compound class for treating CRPC. Citation Format: Justine Habault, Jeffrey A. Schneider, Susan Ha, Rachel Ruoff, Joseph Puccini, Dafna Bar-Sagi, Kwok-Kin Wong, Amina Zoubeidi, Frank Claessens, David R. Wise, Susan K. Logan, Kent Kirshenbaum, Michael J. Garabedian. A multivalent peptoid conjugate that inhibits therapy-resistant prostate cancer cell proliferation by modulating androgen receptor transcriptional activity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3441.
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40

SIMS, R. L. "KENNETH J. RUOFF: The people's emperor: democracy and the Japanese monarchy, 1945–1995. (Harvard East Asian Monographs, 211.) xiv, 331 pp. Cambridge, MA and London: Harvard University Asia Center, 2001. £30.95." Bulletin of the School of Oriental and African Studies 66, no. 1 (February 2003): 149–51. http://dx.doi.org/10.1017/s0041977x03650068.

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41

Almuzara, Marisa, Claudia Barberis, Viviana Rojas Velázquez, Maria Soledad Ramirez, Angela Famiglietti, and Carlos Vay. "Matrix-assisted Laser Desorption Ionization-Time-of-Flight Mass Spectrometry (MALDI-TOF MS) as a Reliable Tool to Identify Species of Catalase-negative Gram-positive Cocci not Belonging to the Streptococcus Genus." Open Microbiology Journal 10, no. 1 (December 28, 2016): 202–8. http://dx.doi.org/10.2174/1874285801610010202.

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Objective:To evaluate the performance of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) by using 190 Catalase-negative Gram-Positive Cocci (GPC) clinical isolates.Methods:All isolates were identified by conventional phenotypic tests following the proposed scheme by Ruoff and Christensen and MALDI-TOF MS (Bruker Daltonics, BD, Bremen, Germany). Two different extraction methods (direct transfer formic acid method on spot and ethanol formic acid extraction method) and different cut-offs for genus/specie level identification were used. The score cut-offs recommended by the manufacturer (≥ 2.000 for species-level, 1.700 to 1.999 for genus level and <1.700 no reliable identification) and lower cut-off scores (≥1.500 for genus level, ≥ 1.700 for species-level and score <1.500 no reliable identification) were considered for identification. A minimum difference of 10% between the top and next closest score was required for a different genus or species.MALDI-TOF MS identification was considered correct when the result obtained from MS database agreed with the phenotypic identification result.When both methods gave discordant results, the 16S rDNA orsodAgenes sequencing was considered as the gold standard identification method. The results obtained by MS concordant with genes sequencing, although discordant with conventional phenotyping, were considered correct. MS results discordant with 16S orsodA identification were considered incorrect.Results:Using the score cut-offs recommended by the manufacturer, 97.37% and 81.05% were correctly identified to genus and species level, respectively. On the other hand, using lower cut-off scores for identification, 97.89% and 94.21% isolates were correctly identified to genus and species level respectively by MALDI-TOF MS and no significant differences between the results obtained with two extraction methods were obtained.Conclusion:The results obtained suggest that MALDI-TOF MS has the potential of being an accurate tool for Catalase-negative GPC identification even for those species with difficult diagnosis asHelcococcus,Abiotrophia,Granulicatella, among others. Nevertheless, expansion of the library, especially including more strains with different spectra on the same species might overcome potential “intraspecies” variability problems. Moreover, a decrease of the identification scores for species and genus-level identification must be considered since it may improve the MALDI-TOF MS accuracy.
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42

Schencking, J. Charles. "Kenneth J. Ruoff . Imperial Japan at Its Zenith: The Wartime Celebration of the Empire's Two Thousand Six‐hundredth Anniversary . (Studies of the Weatherhead East Asian Institute, Columbia University.) Ithaca: Cornell University Press. 2010. Pp. xv, 236. $39.95." American Historical Review 117, no. 1 (February 2012): 179–80. http://dx.doi.org/10.1086/ahr.117.1.179.

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43

Potrokhov, O. S., O. G. Zinkovskiy, Yu M. Khudiyash, and O. M. Vodianitskiy. "Changes in Hormonal Status of Aboriginal Fishes under the Impact of Agricultural Runoffs." Hydrobiological Journal 59, no. 5 (2023): 101–9. http://dx.doi.org/10.1615/hydrobj.v59.i5.70.

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Changes of cortisol, triiodothyronine, and thyroxine content in the blood plasma of perch, ruff, rudd and bleak under the impact of agricultural runoff from the adjacent territories to the water bodies were studied. Under the long-term exposure to the contaminated water, the weight and size of fish their growth rates specimens significantly decreased. The hormonal responses to the polluted waters impact are species-specific and partly depend on the ecological features of the species. Under the chronic impact of the polluted water, the cortisol content in blood plasma decreases and triiodothyronine content increases as compared to the control. The fishes occurring in the surface water layers create the thyroxine reserve in blood, and fishes which prefer the near-bottom layers use it to increase the triiodothyronine content. After treatment of the fields close to the reservoir with pesticides, the ruff and rudd develop the active stress reaction, the cortisol and thyroxine content in blood significantly increases. According to the considered indicators, the bleak is the most resistant to agricultural runoffs or possesses the ability to avoid toxic water pollution.
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Cruz-Arévalo, Brenda, Francisco Gavi-Reyes, Mario Martínez-Menez, and Juan Juárez-Méndez. "Uso de suelo y su efecto en el escurrimiento modelado con SWAT." Tecnología y ciencias del agua 12, no. 2 (2021): 01–34. http://dx.doi.org/10.24850/j-tyca-2021-02-04.

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La importancia de los modelos de simulación para el monitoreo de los recursos naturales cada vez es mayor. El objetivo del presente estudio fue aplicar el modelo SWAT (Soil Water Assessment Tool) para evaluar el impacto del cambio de uso de suelo sobre el escurrimiento y sedimentos en la cuenca del Río Chapingo de 1999 a 2015. Se generaron dos mapas de uso de suelo mediante la fotointerpretación de imágenes Landsat y RapidEye con resoluciones de 15 y 5 m, respectivamente y recorridos de campo para verificación. Ante la falta de datos de escurrimiento confiable y reciente se utilizaron los registros mensuales de los períodos 1964-1970 y 1971-1975 para la calibración y validación del modelo. En este proceso los coeficientes de Nash-Sutcliffe fueron de 0.58 y 0.52, respectivamente. El uso de suelo de la cuenca en el período de estudio cambió: agricultura (-6.9 %) zona urbana (+2.89%), área de minería (+5.04 %) y pastizal (+7.75 %). La aplicación del SWAT calibrado y validado sólo para escurrimiento para el período 1999-2015 no detectó cambios en el escurrimiento (p = 0.2351) y sedimentos (p = 0.4430) en función del cambio de uso de suelo determinado. La correlación entre el escurrimiento y sedimentos anuales simulados con SWAT fue significativa (p = 0.0116) con un R2 bajo (0.36), atribuible a la falta de datos de campo de sedimentos para calibrar y validar el SWAT, además de la presencia de acciones de conservación de suelo y agua en la cuenca estudiada.
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45

Oh, Y. J., and K. W. Moon. "POS1120 PRESENCE OF TOPHI IS ASSOCIATED WITH A RAPID DECLINE IN THE RENAL FUNCTION IN PATIENTS WITH GOUT." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 839.1–839. http://dx.doi.org/10.1136/annrheumdis-2021-eular.50.

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Background:Gout is the most common inflammatory arthritis resulting from a chronic deposition of MSU crystals in the joints and other soft tissues. After the process of repeated tissue damage and repair due to gout, tophi could be formed around the affected joints. Intra-articular tophi may sometimes result in bone destruction, joint deformities, and dysfunction which can adversely affect the patient’s quality of life. Furthermore, early-onset tophaceous gout patients are more likely to develop renal dysfunction, however, few studies have investigated if the presence of tophi is related with the progression of renal dysfunction in gout patients.Objectives:We aimed to compare clinical characteristics of patients with and without tophi at the time of the diagnosis of gout and investigate the effect of tophi on the renal function in gout patients.Methods:Data of 257 patients who were first diagnosed with gout at the Kangwon National University Hospital from January 2012 to December 2018 were retrospectively studied. Patients were divided into 2 groups according to the presence of tophi at the diagnosis. We compared clinical characteristics and the progression of renal dysfunction between the two groups.Results:Of all patients, 66 (25.5%) initially presented with tophi. Patients with tophi were older, had a longer duration of symptoms, and had a higher prevalence of multiple joint involvement than those without tophi. The decline in the eGFR was more prominent in patients with tophi than in those without (-4.8±14.5 ml/min/1.73m2vs. -0.7±11.9 ml/min/1.73m2, respectively; P=0.039). In multivariate logistic regression analysis, a prolonged symptom duration (odds ratio [OR], 1.010; 95% confidence interval [CI], 1.004–1.017; P=0.001) and multiple joint involvement (OR, 3.027; 95% CI, 1.831–5.004; P<0.001) were significantly associated with increased risk of formation of tophi. The presence of tophi was significantly associated with a rapid decline in the eGFR (β=-0.141; P=0.035).Conclusion:A prolonged symptom duration and multiple joint involvement were independent risk factors for tophi as the presenting symptom in gout patients. The presence of tophi was associated with a declining renal function. Therefore, an early diagnosis and active treatment are important in tophaceous gout.References:[1]Bardin T, Richette P. Definition of hyperuricemia and gouty conditions. Curr Opin Rheumatol 2014;26:186-91.[2]Liu F, Du GL, Song N, Ma YT, Li XM, Gao XM, et al. Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008-2012). Lipids Health Dis 2020;19:58.[3]Dalbeth N, Merriman TR, Stamp LK. Gout. Lancet 2016;388:2039-52.[4]Ruoff G, Edwards NL. Overview of Serum Uric Acid Treatment Targets in Gout: Why Less Than 6 mg/dL? Postgrad Med 2016;128:706-15.[5]Bieber A, Schlesinger N, Fawaz A, Mader R. Chronic tophaceous gout as the first manifestation of gout in two cases and a review of the literature. Semin Arthritis Rheum 2018;47:843-8.Disclosure of Interests:None declared.
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Daverede, I. C., A. N. Kravchenko, R. G. Hoeft, E. D. Nafziger, D. G. Bullock, J. J. Warren, and L. C. Gonzini. "Phosphorus Runoff." Journal of Environment Quality 32, no. 4 (2003): 1436. http://dx.doi.org/10.2134/jeq2003.1436.

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Funaki, Brian. "CTA Runoff." Seminars in Interventional Radiology 25, no. 03 (September 2008): 323–28. http://dx.doi.org/10.1055/s-0028-1085933.

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Jeong, Dong-Guk, and Beom-Hui Lee. "Urban Watershed Runoff Analysis Using Urban Runoff Models." Journal of Korea Water Resources Association 36, no. 1 (February 1, 2003): 75–85. http://dx.doi.org/10.3741/jkwra.2003.36.1.075.

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MATSUYAMA, Hiroshi, and Takeki IZUMI. "Snowmelt runoff analysis using SRM (Snowmelt Runoff Model)." JOURNAL OF JAPAN SOCIETY OF HYDROLOGY AND WATER RESOURCES 22, no. 5 (2009): 409–18. http://dx.doi.org/10.3178/jjshwr.22.409.

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ARAI, Tadashi. "An Essay on Runoff Ratio and Runoff Height." Journal of Japanese Association of Hydrological Sciences 31, no. 1 (2001): 1_3–1_10. http://dx.doi.org/10.4145/jahs.31.1_3.

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