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Academic literature on the topic 'Rsc2'

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Published: 9 March 2023
Last updated: 10 March 2023

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Journal articles on the topic "Rsc2"

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Andrej Kupecsek and Juliana Monárová. "The influence of fertilization and tillage method on the formation root system capacity and grain production of spring barley." Acta Agraria Debreceniensis, no. 44 (November 20, 2011): 89–93. http://dx.doi.org/10.34101/actaagrar/44/2613.

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To evaluate the interaction of year x variety, year x tillage method and year x fertilization on the grain yield and root system capacity (RSC) of spring barley, we ran polyfactorial field trials in agroecological conditions of a warm corn production area in Slovakia, at Malanta, in 2009 and 2010. The RSC measurements were done using LCR - meter at a frequency of 1 kHz and they took place in four growth stages: at leaf development in the stage of four leaves (RSC1), in full tillering (RSC2), in the stage heading (RSC 3) and at the stage of ripening (RSC4). The values of grain yield, RSC1, RSC2, RSC3, RSC4 reached in 2009 comparison to 2010 were significantly lower. The highest yield in 2009 was reached by variety Marthe (4.49 t.ha-1) and by variety Bojos (7.19 t ha-1) in 2010. The highest values of RSC in observed growth stages were achieved by variety Bojos in 2009, and in 2010 also besides RSC1. Within both years, difference in yields between tillage methods was not observed. The values of RSC in growth stage of 4 leaves and tillering was higher at conventional tillage, butthe values of RSC3 and RSC4 were higher with minimized tillage. The highest grain yield and values of RSC in every growth stage were achieved on the fertilization variant “c“ in 2009 and on the fertilization variant “b“ in 2010. The correlation relationships between grain yield and RSC were significant and positive in every growth stage. The strongest relationship was found among grain yield and RSC (r=0.6047).
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Bungard, David, Michelle Reed, and Edward Winter. "RSC1 and RSC2 Are Required for Expression of Mid-Late Sporulation-Specific Genes in Saccharomyces cerevisiae." Eukaryotic Cell 3, no. 4 (August 2004): 910–18. http://dx.doi.org/10.1128/ec.3.4.910-918.2004.

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ABSTRACT Rsc1 and Rsc2 are alternative bromodomain-containing subunits of the ATP-dependent RSC chromatin remodeling complex in Saccharomyces cerevisiae. Smk1 is a sporulation-specific mitogen-activated protein kinase homolog that is required for the postmeiotic events of spore formation. In this study we show that RSC1 and RSC2 are haploinsufficient for spore formation in a smk1 hypomorph. Moreover, diploids lacking Rsc1 or Rsc2 show a subset of smk1-like phenotypes. High-copy-number RSC1 plasmids do not suppress rsc2-Δ/rsc2-Δ sporulation defects, and high-copy-number RSC2 plasmids do not suppress rsc1-Δ/rsc1-Δ sporulation defects. Mid-late sporulation-specific genes, which are normally expressed while key steps in spore assembly occur and which include genes that are required for spore wall formation, are not expressed in cells lacking Rsc1 or Rsc2. We speculate that the combined action of Rsc1 and Rsc2 at mid-late promoters is specifically required for the proper expression of this uniquely timed set of genes. Our data suggest that Smk1 and Rsc1/2 define parallel pathways that converge to provide signaling information and the expression of gene products, respectively, that are required for spore morphogenesis.
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Wong, Michael C. V. L., Suzanna R. S. Scott-Drew, Matthew J. Hayes, Philip J. Howard, and James A. H. Murray. "RSC2, Encoding a Component of the RSC Nucleosome Remodeling Complex, Is Essential for 2μm Plasmid Maintenance in Saccharomyces cerevisiae." Molecular and Cellular Biology 22, no. 12 (June 15, 2002): 4218–29. http://dx.doi.org/10.1128/mcb.22.12.4218-4229.2002.

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ABSTRACT The stable maintenance of the 2μm circle plasmid depends on its ability to overcome intrinsic maternal inheritance bias, which in yeast normally results in the failure to transmit DNA molecules efficiently to daughter cells. In addition to the plasmid proteins Rep1 and Rep2 acting on the plasmid DNA locus STB, it is likely that other chromosomally encoded yeast proteins are required. We have isolated mutants of yeast unable to maintain 2μm and found that RSC2 is essential for 2μm to overcome maternal inheritance bias. Rsc2 is part of a multisubunit RSC chromatin remodeling complex, and we show that in the absence of Rsc2 the chromatin structure of the STB region is significantly altered and the Rep1 protein loses its normal localization to subnuclear foci. Rsc1, a closely related homolog of Rsc2 present in an alternative form of the RSC complex, is not required for 2μm maintenance and does not replace the requirement for Rsc2 when overexpressed. This represents the first specific role for Rsc2 that has been related to a change in chromatin structure, as well as the first direct evidence linking chromatin structure to 2μm segregation.
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Baetz, Kristin K., Nevan J. Krogan, Andrew Emili, Jack Greenblatt, and Philip Hieter. "The ctf13-30/CTF13 Genomic Haploinsufficiency Modifier Screen Identifies the Yeast Chromatin Remodeling Complex RSC, Which Is Required for the Establishment of Sister Chromatid Cohesion." Molecular and Cellular Biology 24, no. 3 (February 1, 2004): 1232–44. http://dx.doi.org/10.1128/mcb.24.3.1232-1244.2003.

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ABSTRACT The budding yeast centromere-kinetochore complex ensures high-fidelity chromosome segregation in mitosis and meiosis by mediating the attachment and movement of chromosomes along spindle microtubules. To identify new genes and pathways whose function impinges on chromosome transmission, we developed a genomic haploinsufficiency modifier screen and used ctf13-30, encoding a mutant core kinetochore protein, as the reference point. We demonstrate through a series of secondary screens that the genomic modifier screen is a successful method for identifying genes that encode nonessential proteins required for the fidelity of chromosome segregation. One gene isolated in our screen was RSC2, a nonessential subunit of the RSC chromatin remodeling complex. rsc2 mutants have defects in both chromosome segregation and cohesion, but the localization of kinetochore proteins to centromeres is not affected. We determined that, in the absence of RSC2, cohesin could still associate with chromosomes but fails to achieve proper cohesion between sister chromatids, indicating that RSC has a role in the establishment of cohesion. In addition, numerous subunits of RSC were affinity purified and a new component of RSC, Rtt102, was identified. Our work indicates that only a subset of the nonessential RSC subunits function in maintaining chromosome transmission fidelity.
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Rossio, Valentina, Elena Galati, Matteo Ferrari, Achille Pellicioli, Takashi Sutani, Katsuhiko Shirahige, Giovanna Lucchini, and Simonetta Piatti. "The RSC chromatin-remodeling complex influences mitotic exit and adaptation to the spindle assembly checkpoint by controlling the Cdc14 phosphatase." Journal of Cell Biology 191, no. 5 (November 22, 2010): 981–97. http://dx.doi.org/10.1083/jcb.201007025.

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Upon prolonged activation of the spindle assembly checkpoint, cells escape from mitosis through a mechanism called adaptation or mitotic slippage, which is thought to underlie the resistance of cancer cells to antimitotic drugs. We show that, in budding yeast, this mechanism depends on known essential and nonessential regulators of mitotic exit, such as the Cdc14 early anaphase release (FEAR) pathway for the release of the Cdc14 phosphatase from the nucleolus in early anaphase. Moreover, the RSC (remodel the structure of chromatin) chromatin-remodeling complex bound to its accessory subunit Rsc2 is involved in this process as a novel component of the FEAR pathway. We show that Rsc2 interacts physically with the polo kinase Cdc5 and is required for timely phosphorylation of the Cdc14 inhibitor Net1, which is important to free Cdc14 in the active form. Our data suggest that fine-tuning regulators of mitotic exit have important functions during mitotic progression in cells treated with microtubule poisons and might be promising targets for cancer treatment.
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Chambers, Anna L., Laurence H. Pearl, Antony W. Oliver, and Jessica A. Downs. "The BAH domain of Rsc2 is a histone H3 binding domain." Nucleic Acids Research 41, no. 19 (July 31, 2013): 9168–82. http://dx.doi.org/10.1093/nar/gkt662.

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Hajra, Sujata, Santanu Kumar Ghosh, and Makkuni Jayaram. "The centromere-specific histone variant Cse4p (CENP-A) is essential for functional chromatin architecture at the yeast 2-μm circle partitioning locus and promotes equal plasmid segregation." Journal of Cell Biology 174, no. 6 (September 11, 2006): 779–90. http://dx.doi.org/10.1083/jcb.200603042.

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The centromere protein A homologue Cse4p is required for kinetochore assembly and faithful chromosome segregation in Saccharomyces cerevisiae. It has been regarded as the exquisite hallmark of centromeric chromatin. We demonstrate that Cse4 resides at the partitioning locus STB of the 2-μm plasmid. Cse4p-STB association is absolutely dependent on the plasmid partitioning proteins Rep1p and Rep2p and the integrity of the mitotic spindle. The kinetochore mutation ndc10-1 excludes Cse4p from centromeres without dislodging it from STB. Cse4p-STB association lasts from G1/S through late telophase during the cell cycle. The release of Cse4p from STB chromatin is likely mediated through spindle disassembly. A lack of functional Cse4p disrupts the remodeling of STB chromatin by the RSC2 complex, negates Rep2p binding and cohesin assembly at STB, and causes plasmid missegregation. Poaching of a specific histone variant by the plasmid to mark its partitioning locus with a centromere tag reveals yet another one of the molecular trickeries it performs for achieving chromosome- like fidelity in segregation.
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Nelson, Kristin M., Glenn M. Young, and Virginia L. Miller. "Identification of a Locus Involved in Systemic Dissemination of Yersinia enterocolitica." Infection and Immunity 69, no. 10 (October 1, 2001): 6201–8. http://dx.doi.org/10.1128/iai.69.10.6201-6208.2001.

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ABSTRACT A putative LysR-type transcriptional activator, Hre20, was identified previously in an in vivo expression technology screen designed to identify factors which are expressed early during infection by Yersinia enterocolitica (G. M. Young and V. L. Miller, Mol. Microbiol. 25:319–328, 1997). An insertion in hre20, now designated rscR, resulted in increased splenic dissemination of bacteria during infection in a BALB/c mouse model. A nonpolar mutation was generated inrscR, and examination of this strain in the BALB/c mouse model demonstrated that the mutation in rscR was responsible for the increased dissemination to the spleen that was seen in the original experiments. RscR is homologous to the LysR family of transcriptional regulators; thus, a screen was undertaken to identify genes regulated by RscR. A strain containing an insertion in the chromosomal rscR gene and carrying rscR on a plasmid under the control of the inducible araBAD promoter was mutagenized with an mTn5Km-2 transposon containing a promoterless lacZY. Eighteen insertions were identified which appeared to respond to levels of RscR, and these were classified into four allelic groups based on Southern blot hybridization analysis. Representative members were sequenced from three allelic groups. Sequencing revealed insertions in an ORF with no known homologues, a homologue of OmpF of Serratia marcescens, and a locus (designated rscBAC) with similarity to thehmwABC locus of Haemophilus influenzae. ThehmwABC locus promotes adherence of H. influenzae to host cells (S. J. Barenkamp and J. W. St. Geme III, Infect. Immun. 62:3320–3328, 1994; J. W. St. Geme III, S. Falkow, and S. J. Barenkamp, Proc. Natl. Acad. Sci. USA 90:2875–2879, 1993). A strain containing a deletion mutant of rscA, the hmwA homologue, exhibits increased splenic dissemination of bacteria during infection in a BALB/c mouse model, similar to the rscR mutant. This suggests that the phenotype of an rscR mutant is due to the loss of RscA.
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Hooshyar, Mohsen, Daniel Burnside, Maryam Hajikarimlou, Katayoun Omidi, Alexander Jesso, Megan Vanstone, Adamo Young, et al. "Actin-Related Protein 6 (Arp6) Influences Double-Strand Break Repair in Yeast." Applied Microbiology 1, no. 2 (July 16, 2021): 225–38. http://dx.doi.org/10.3390/applmicrobiol1020017.

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DNA double-strand breaks (DSBs) are the most deleterious form of DNA damage and are repaired through non-homologous end-joining (NHEJ) or homologous recombination (HR). Repair initiation, regulation and communication with signaling pathways require several histone-modifying and chromatin-remodeling complexes. In budding yeast, this involves three primary complexes: INO80-C, which is primarily associated with HR, SWR1-C, which promotes NHEJ, and RSC-C, which is involved in both pathways as well as the general DNA damage response. Here we identify ARP6 as a factor involved in DSB repair through an RSC-C-related pathway. The loss of ARP6 significantly reduces the NHEJ repair efficiency of linearized plasmids with cohesive ends, impairs the repair of chromosomal breaks, and sensitizes cells to DNA-damaging agents. Genetic interaction analysis indicates that ARP6, MRE11 and RSC-C function within the same pathway, and the overexpression of ARP6 rescues rsc2∆ and mre11∆ sensitivity to DNA-damaging agents. Double mutants of ARP6, and members of the INO80 and SWR1 complexes, cause a significant reduction in repair efficiency, suggesting that ARP6 functions independently of SWR1-C and INO80-C. These findings support a novel role for ARP6 in DSB repair that is independent of the SWR1 chromatin remodeling complex, through an apparent RSC-C and MRE11-associated DNA repair pathway.
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Shim, Eun Yong, Soo Jin Hong, Ji-Hyun Oum, Yvonne Yanez, Yu Zhang, and Sang Eun Lee. "RSC Mobilizes Nucleosomes To Improve Accessibility of Repair Machinery to the Damaged Chromatin." Molecular and Cellular Biology 27, no. 5 (December 18, 2006): 1602–13. http://dx.doi.org/10.1128/mcb.01956-06.

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ABSTRACT Repair of DNA double-strand breaks (DSBs) protects cells and organisms, as well as their genome integrity. Since DSB repair occurs in the context of chromatin, chromatin must be modified to prevent it from inhibiting DSB repair. Evidence supports the role of histone modifications and ATP-dependent chromatin remodeling in repair and signaling of chromosome DSBs. The key questions are, then, what the nature of chromatin altered by DSBs is and how remodeling of chromatin facilitates DSB repair. Here we report a chromatin alteration caused by a single HO endonuclease-generated DSB at the Saccharomyces cerevisiae MAT locus. The break induces rapid nucleosome migration to form histone-free DNA of a few hundred base pairs immediately adjacent to the break. The DSB-induced nucleosome repositioning appears independent of end processing, since it still occurs when the 5′-to-3′ degradation of the DNA end is markedly reduced. The tetracycline-controlled depletion of Sth1, the ATPase of RSC, or deletion of RSC2 severely reduces chromatin remodeling and loading of Mre11 and Yku proteins at the DSB. Depletion of Sth1 also reduces phosphorylation of H2A, processing, and joining of DSBs. We propose that RSC-mediated chromatin remodeling at the DSB prepares chromatin to allow repair machinery to access the break and is vital for efficient DSB repair.
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Dissertations / Theses on the topic "Rsc2"

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GALATI, ELENA. "Yeast response to prolonged activation of the spindle assembly checkpoint." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/19557.

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Faithful chromosome segregation during mitosis is fundamental for cell viability and genome stability. For a correct division, all kinetochores must be attached to the mitotic spindle and cohesion must be timely removed. Anaphase is triggered by the Anaphase Promoting Complex bound to its regulatory subunit Cdc20 (APC-Cdc20) that polyubiquitylates securin (Pds1 in budding yeast), whose role is to maintain inactive the protease separase (Esp1 in budding yeast) until anaphase onset. Once active, separase cleaves cohesin, thus triggering sister chromatid separation. Separase also promotes cyclinB proteolysis and mitotic exit due to its involvement in the Cdc14-early anaphase release (FEAR) pathway that promotes a partial activation of the Cdc14 phophatase, which is in turn key for CDK inactivation and mitotic exit. Cdc14 is maintained inactive throughout most of the cell cycle bound to its inhibitor Net1/Cfi1 and trapped in the nucleolus. At the beginning of anaphase Cdc14 is released from the nucleolus into the nucleus by the FEAR pathway; subsequently, Cdc14 is released also in the cytoplasm by the MEN (Mitotic Exit Network) pathway. In this way Cdc14 is fully active and can trigger mitotic exit by cyclinB-CDK inactivation. The Spindle Assembly Checkpoint (SAC) is a surveillance mechanism conserved in all eukaryotic organisms that ensures the correct segregation of the genetic material. In fact, it inhibits the metaphase to anaphase transition until all kinetochores are properly attached to the mitotic spindle by inactivating the APC-Cdc20 complex, thus providing the time for error correction. Cells do not arrest indefinitely upon SAC activation. After a variable period of time cells escape from the metaphase arrest also in the presence of a damaged mitotic spindle or faulty kinetochore attachments to spindle microtubules. This process is referred to as adaptation or mitotic slippage and is often involved in the resistance to chemotherapeutic compounds that target the mitotic spindle. In spite of its importance, the adaptation process is still little known. Within this context, the goals of my Ph.D. were: (1) to characterize the molecular mechanisms underlying SAC adaptation and (2) to search for factors involved in this process. For these purposes we used the yeast Saccharomyces cerevisiae as a model organism. (1) We characterized the adaptation process in either the presence or the absence of mitotic spindle perturbations. We depolymerized spindles by using two different drugs that alter microtubule dynamics, i.e. nocodazole and benomyl, whereas we induced SAC hyperactivation without spindle damage by overproducing Mad2 (GAL1-MAD2 cells), one of the key proteins for SAC signal generation and maintenance. We observed that in all the conditions cells are able to adapt, but with different kinetics. In particular, cells adapt faster in benomyl, while in nocodazole and with high levels of Mad2 cells need more time to slip out of mitosis. The few data available about SAC adaptation in higher eukaryotes indicate that SAC adaptation is accompanied by chromatid separation, a decrease in mitotic CDK activity and mitotic exit. Indeed, like in mammalian cells, yeast securin and cyclinB are degraded and sister chromatids are separated during adaptation. In addition, cyclinB stabilization, as well as Cdc20 and Cdc5 (polo kinase) inactivation, markedly delay adaptation, while the only yeast CKI (Sic1) is not involved in this process. Finally, when yeast cells adapt the SAC is likely to be turned off, as shown by the disassembly of the Mad1/Bub3 checkpoint complex. (2) To search for factors involved in SAC adaptation, we performed a genetic screen using GAL1-MAD2 cells. In particular, we screened for mutants that would remain arrested for prolonged times in mitosis upon MAD2 overexpression. We identified Rsc2, a non-essential component of the RSC chromatin remodelling complex, as a regulator of SAC adaptation in yeast. We demonstrated that RSCRsc2 is involved in fine tuning mitotic exit during the unperturbed cell cycle. Its activity becomes particularly important in conditions that would activate the SAC, as it contributes to cyclinB degradation. In the absence of Rsc2 Net1 phosphorylation and the early anaphase release of Cdc14 from the nucleolus are impaired, whereas expression of a dominant allele of CDC14 that loosens Net1 inhibition (CDC14TAB6-1) is sufficient to restore mitotic exit in conditions where Rsc2 becomes essential for this process. We further demonstrated that the ATPase activity of RSC is required for mitotic exit regulation, suggesting that its chromatin-remodelling activity is involved in this process. By studying possible genetic interactions between the RSC2 deletion and FEAR or MEN mutations, we found that RSC2 deletion confers synthetic lethality or sickness to MEN but not to FEAR mutants. Altogether, our data suggest that RSCRsc2 is a novel component of the FEAR pathway. Finally, we demonstrated that Rsc2 interacts in vivo and in vitro with the polo kinase Cdc5, which controls mitotic exit at different levels. Since RSC binds to acetylated histone tails, it is possible that histone transacetylases are also involved in SAC adaptation. We tested if the SAGA (Spt-Ada-Gcn5 Acetyltransferase) complex is involved in SAC adaptation by deleting ADA2 or GCN5 in yeast. Indeed, SAGA seems involved in adaptation, although the contribution of Ada2 and Gcn5 in the process differs depending on the conditions used to activate the SAC. Finally, since we found that upon treatment with benomyl (a microtubule destabilizer) cells adapt dividing nuclei, we wondered if SAC adaptation could be linked to the presence of cytoplasmic microtubules that are still partially detectable in these conditions. We therefore asked whether motor proteins and microtubule regulators are involved in mitotic slippage. Indeed, we found that in the absence of Kip2 and Bik1, which specifically bind to cytoplasmic microtubules, cells divide nuclei and exit mitosis slower than wild type cells, demonstrating that cytoplasmic microtubules and associated proteins could accelerate SAC adaptation. In conclusion, SAC adaptation is a very complex process whose timing probably depends on the interplay between different mechanisms. An important aim for a complete comprehension of this process, as well as for the development of new and more efficient cancer therapies, will be to identify novel factors implicated in adaptation and clarify how their function might be linked to one another.
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Bauer, Vladimír. "Finanční analýza společnosti Euro RSCG, a. s." Master's thesis, Vysoká škola ekonomická v Praze, 2006. http://www.nusl.cz/ntk/nusl-403.

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Cílem práce je posoudit finanční zdraví společnosti Euro RSCG, a. s. s důrazem na charakteristiky reklamního odvětví. První část práce se věnuje popisu reklamního odvětví a blíže jsou popsány pojmy reklama, komunikační proces, subjekty reklamního trhu. Samotatná kapitola je věnována popisu reklamních médií a mediálním ukazatelům. V další část je zaměřená na společnost Euro RSCG, a. s. Další část obsahuje finanční analýzu vybrané společnosti.
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Meyer, Maria. "TheFamily of RSK Proteins : Genetic aspects of coffin-lowry syndrome, involving RSK2, and functional studies on RSK2 and two related proteins, RSK1 and RSK3." Université Louis Pasteur (Strasbourg) (1971-2008), 2002. http://www.theses.fr/2002STR13093.

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Les retards mentaux liés au chromosome X peuvent être syndromiques (MRXS) ou non-syndromiques (MRX). Dans le cas du syndrome de Coffin-Lowry (CLS), une forme de MRXS, le retard mental est associé à des anomalies notamment squelettiques. Des mutations de perte de fonction de RSK2 sont la cause de ce syndrome. Chez l'homme, RSK2 fait partie d'une famille de quatre kinases de la voie Ras/ERK-MAPK. Nous avons identifié une mutation dans le gène RSK2 dans une famille MRX, ce qui élargit le spectre phénotypique des mutations dans ce gène. Nous avons aussi montré que les techniques de western blot et de test kinase in vitro peuvent être utilisées pour le diagnostic moléculaire de CLS. Ces techniques associées à une recherche de mutations dans le promoteur du gène RSK2, ont suggéré une probable hétérogénéité génétique en ce qui concerne ce syndrome. Elles ont aussi permis l'identification de deux mutations inhabituelles d'épissage que nous avons étudié en détail. Afin de mieux comprendre les fonctions des RSKs, nous avons généré des anticorps reconnaissant spécifiquement les protéines RSK1, 2 et 3. Ces anticorps ont permis de déterminer qu' alors que RSK3 est présente de manière uniforme dans le cytoplasme et le noyau des cellules, RSK1 est principalement détectée dans des zones bien délimitées du noyau, les "speckles". Nous avons utilisé ces anticorps ainsi que les techniques de northern blot et d'hybridation in situ afin de déterminer l'expression tissulaire des RSKs. RSK1, 2 et 3 étaient toutes exprimées dans un grand nombre de tissus. Cependant, uniquement RSK2 est fortement exprimée dans certains régions du cerveau adulte impliquées dans des processus de mémoire, ce qui pourrait expliquer le déficit cognitif observé chez les patients CLS. Enfin, nous avons généré des souris invalidées pour l'expression des gènes Rsk1 et Rsk3, qui avec les animaux invalidés pour l'expression de Rsk2, seront utiles pour l'identification des fonctions spécifiques et redondantes des RSKs
Mental retardation (MR) affects 1 to 1. 5% of the population. X-linked mental retardation is divided into two classes: syndromic (MRXS) and nonsyndromic or nonspecific (MRX). The Coffin-Lowry syndrome (CLS) is a form of MRXS in which the cognitive deficit is associated to growth retardation and skeletal malformations. CLS is caused by loss of function mutations in the RSK2 gene encoding the RSK2 protein. In humans, RSK2 is member of a family of four highly related serine/threonine kinases (RSK1-4) acting in the Ras/ERK-MAPK signaling pathway and involved in various cellular processes. We found a mutation in the RSK2 gene in an MRX family, extending the phenotypic variability in patients carrying RSK2 mutations. We also showed that western blotting and in vitro kinase assays are efficient tests for molecular diagnosis of CLS. These tests along with a high scale mutational screening in the promoter region of RSK2, indicated that genetic heterogeneity in CLS should not be excluded. Western blotting allowed also the identification of two unusual splicing mutations that were studied in detail. To better understand the functions of RSK proteins, we generated polyclonal antibodies recognizing specifically RSK1, 2 and 3. These antibodies were used to determine that whereas RSK3 was uniformly distributed in the cytoplasmic and nuclear compartments, RSK1 was mainly detected in nuclear speckles, suggesting a putative role of RSK1 in splicing processes. We have also used these antibodies, as well as northern blotting and in situ hybridization, to study the tissue expression of RSKs. RSK1, 2 and 3 were all widely expressed. However, only RSK2 was detected in some brain areas involved in memory processes, providing a possible explanation for the cognitive deficit observed in CLS patients. Finally, we have generated Rsk1 and Rsk3 knockout mice which will be useful, along with the Rsk2 knockout animals, for the identification of specific as well as redundant functions of RSKs
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Bossonaro, Adriano Aleixo. "Método RSCT reengenharia de software orientada a componentes usando transformações." Universidade Federal de São Carlos, 2004. https://repositorio.ufscar.br/handle/ufscar/624.

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Made available in DSpace on 2016-06-02T19:06:27Z (GMT). No. of bitstreams: 1 DissAAB.pdf: 2236709 bytes, checksum: 5e5fccf55f07efba73b03e599b8020e2 (MD5) Previous issue date: 2004-08-16
This project researched a Component-Oriented Software Reengineering Method using Transformations, named RSCT. The researched method extends the RST Method [Fon02a, Fon02b, Fon02c, Fon02d, Fon04], adding resources to treat the component-based reengineering. The RSCT aims to guide the components construction and reuse in the reengineering of legacy systems. The method is supported by two tools: a Software Transformation System, named Draco-PUC and a CASE tool, named MVCASE, and is divided in 4 (four) phases. In Phase 1, Construct Domains and Transformers, it is obtained the domains and transformers used in the legacy system reverse engineering to obtain of Object-Oriented Design. In Phase 2, Obtain Object-Oriented Design, it is obtained the legacy system object-oriented recovered design, using the domains and transformers constructed in Phase 1. In Phase 3, Construct Components, it is obtained the components of the legacy system domain, from the objectoriented recovered designs in Phase 2. With the MVCASE support, the Software Engineering analyses and refines each Object-Oriented design and uses design patterns to construct the components, making them available in a library. Finally, in Phase 4, Reconstruct Systems, the legacy systems are reconstructed from their object-oriented designs, obtained in Phase 2, reusing the components available in the library.
Este projeto pesquisou um Método de Reengenharia de Software Orientada a Componentes usando Transformações, denominado RSCT. O método pesquisado estende o Método RST [Fon02a, Fon02b, Fon02c, Fon02d, Fon04], adicionando recursos para tratar a reengenharia baseada em componentes. O RSCT tem como objetivo orientar a construção e reuso de componentes de software na reengenharia de sistemas legados. Na execução do método, o Engenheiro de Software é apoiado por duas ferramentas: o Sistema de Transformação Draco-PUC e a ferramenta CASE (Computer Aided Software Engineering) MVCASE, e está dividido em 04 (quatro) fases. Na Fase 1, Construir Domínios e Transformadores, obtêm-se os domínios e transformadores de software que são usados na Engenharia Reversa do sistema legado para a obtenção de seu Projeto Orientado a Objetos. Na Fase 2, Obter Projeto Orientado a Objetos, com o apoio do Sistema de Transformação Draco-PUC, obtém-se o projeto Orientado a Objetos recuperado do sistema legado, usando os domínios e transformadores construídos na Fase 1. Na Fase 3, Construir Componentes, obtêm-se os componentes do domínio do sistema legado, a partir dos projetos Orientados a Objetos recuperados na Fase 2. Com o apoio da ferramenta MVCASE, o Engenheiro de Software analisa e refina cada projeto Orientado a Objetos e utiliza padrões de projeto para construir os componentes, disponibilizando-os em uma biblioteca. Finalmente, na Fase 4, Reconstruir Sistemas, são reconstruídos os sistemas legados, a partir dos seus projetos Orientados a Objetos obtidos na Fase 2, fazendo reuso dos componentes disponíveis na biblioteca.
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Thompson, Jeffrey M. "Computer aided design and synthesis of the RSCR spatial mechanism." Thesis, Virginia Polytechnic Institute and State University, 1987. http://hdl.handle.net/10919/80087.

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Recent efforts in computer aided design and computer aided manufacturing have stressed the development of robotics. However, there are many applications where a spatial mechanism could be used in place of a robot, but the mechanism design theory has not been fully developed. This thesis presents the fundamentals of a computer aided design system for the RSCR (revolute-spheric-cylindric-revolute) spatial mechanism. Exact relationships for position, velocity, and acceleration analysis have been derived. Closed form synthesis equations have been developed for the RS and RC dyads. The theory developed in this thesis has been implemented on the digital computer in the form of a FORTRAN77 computer program. This computer implementation includes interfaces with MECHIN, a graphical preprocessor for spatial mechanism synthesis and analysis, and GENMOD, an automatic model generator for spatial mechanisms.
Master of Science
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6

Brioudes, Estelle. "RSK2 et Greatwall, deux AGC kinases actrices de la mitose." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20251/document.

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La mitose est une phase importante du cycle cellulaire. Les mécanismes de surveillance s'assurent de l'ordre et de l'exécution correcte des événements du cycle cellulaire dont les erreurs peuvent conduire à l'aneuploïdie. Pendant la mitose, la séparation des chromatides sœurs est régulée par le point de contrôle du fuseau mitotique qui s'assure que tous les chromosomes sont correctement alignés sur la plaque métaphasique. L'entrée et la sortie de mitose sont régulées par l'activation et l'inactivation du complexe cycline B/Cdk1. Cette fine régulation fait intervenir de nombreuses kinases et phosphatases. Dans ce projet nous nous sommes intéressés plus particulièrement à deux AGC kinases : RSK2 et Greatwall (Gwl).Au cours de cette étude nous nous sommes proposés d'analyser l'implication de RSK2, substrat majeur de la MAPK, dans le point de contrôle du fuseau mitotique. Nos résultats montrent que RSK2 est essentielle pour l'activité du point de contrôle du fuseau mitotique dans les extraits d'œufs de xénope ainsi que pour la localisation des autres protéines de ce mécanisme de surveillance localisées aux kinétochores. Nous montrons également que RSK2 participe au point de contrôle dans les cellules humaines. En effet, RSK2 est nécessaire à la localisation aux kinétochores de Mad1, Mad2 et Cenp-E, protéines essentielles à l'activité de ce checkpoint. L'entrée et la sortie de mitose sont régulées par le complexe cycline B/Cdk1 et des phosphatases. Gwl est une nouvelle kinase essentielle à l'entrée en mitose et au maintien de l'état mitotique dans les extraits d'œufs de xénope. En effet, nos résultats montrent que Gwl maintient l'état mitotique indépendamment du complexe cycline B/Cdk1, en régulant négativement PP2A, une phosphatase responsable de la déphoshorylation des substrats mitotiques
Mitosis is an important phase of cell cycle. The Spindle Assembly Checkpoint (SAC) verifies the orders and the events correct execution of the cell cycle, as errors may lead to aneuploidy. During the mitosis, the checkpoint delays the anaphase onset until all chromosomes are correctly attached to the spindle‘s microtubules. Entry and Exit of mitosis are regulated by the activation and inactivation of cyclin B/Cdk1. A lot of kinases and phosphatases are involved in this fine regulation. In this project, we are particularly focusing on two AGC kinases: RSK2 and Greatwall (Gwl).In this study, we analyzed RSK2, a major substrates of MAPK, involvement in SAC. Our results show that RSK2 is essential to the activation of SAC in xenopus egg extracts and for the localization at the kinétochores of the others SAC components. We also show that RSK2 participate in the maintenance of the SAC in human cells. Indeed, RSK2 is necessary for Mad1, Mad2 and Cenp-E localization, essential proteins for SAC activation.Entry and exit of mitosis are regulated by cyclin B/Cdk1 complex and phosphatases. Gwl is a new kinase essential to the entry into mitosis and maintenance of the mitotic state in xenopus egg extracts. Indeed, our results showed that Gwl maintains the mitotic state independently of cyclin B/Cdk1 but with the negative regulation of PP2A, which dephosphorylate the mitotic substrates
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Durley, Samuel C. "Chromatin remodelling in Sacchromyces cerevisiae by RSC." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/56801/.

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RSC is a member of the multi-subunit SWI/SNF family of ATPase-dependent chromatin remodellers and it is implicated in transcriptional regulation and DNA repair in Saccharomyces cerevisiae. The central ATPase subunit, Sth1, translocates nucleosomes in vitro and mutations in human RSC sub-unit orthologues are implicated in human disease. RSC is found in two isoforms, defined by the presence of either the Rsc1 or Rsc2 subunits, and these appear to confer distinct remodelling functions in different genomic contexts. At the MAT locus, Rsc1 and Rsc2 appear to mediate different forms of nucleosome positioning which are required for efficient mating type switching. Elsewhere in the genome, it has been suggested that RSC can create partially un-wrapped nucleosomes in order to facilitate transcription factor binding. This thesis uses indirect-end-label analysis and chromatin-sequencing technologies to dissect the chromatin remodelling functions of RSC and to determine the roles of Rsc1, Rsc2 and their subdomains. The work presented here suggests that four chromatin-remodelling outcomes arise from RSC activity. Firstly, RSC alters the positions of a tract of nucleosomes abutting HO endonuclease-induced double-strand DNA breaks both at MAT and non-MAT loci in a Rsc1-dependent manner. This activity can be transferred from Rsc1 to Rsc2 by swapping BAH domains. Secondly, RSC can aggregate nucleosomes into a large nuclease-resistant structure, termed an alphasome, in a Rsc2- and Rsc7-dependent manner. Thirdly, RSC positions nucleosomes at tRNA genes in a manner that requires both Rsc1 and Rsc2. Finally, chromatin particles consistent with previously described un-wound nucleosomes are confirmed to be present in specific promoter regions. Although Rsc1- and Rsc2- dependent subsets of these promoters could be identified, and associations with binding motifs for particular transcriptions factors were discovered, it was ultimately not possible to unambiguously define why some gene promoters depend on one RSC sub-unit rather than the other.
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Drapeau, Stéphane. "Rs2. 7 : un canevas adaptable de services de duplication." Grenoble INPG, 2003. http://www.theses.fr/2003INPG0041.

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Darcq, Emmanuel. "Réponses à la morphine in vivo : adaptations moléculaires et implications de la kinase RSK2." Strasbourg, 2009. http://www.theses.fr/2009STRA6155.

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La toxicomanie est une pathologie chronique et récidivante, caractérisée par une recherche compulsive de drogue, une perte de contrôle de la consommation et une très forte probabilité de rechute. La morphine est à la fois une drogue toxicomanogène et un médicament utilisé pour lutter contre des douleurs sévères. L’action pharmacologique de la morphine est médiée par le récepteur aux opioïdes mu. Au sein du laboratoire, nous étudions les adaptations moléculaires et comportementales qui se développent suite à l’activation chronique du récepteur mu. Mon travail de thèse porte sur les régulations géniques et la signalisation intracellulaire associées à l’activation du récepteur mu in vivo. Une première partie de mon travail de thèse a porté sur les adaptations transcriptionnelles consécutives à l’activation chronique du récepteur mu in vivo. Nous nous sommes focalisés sur les régulations de l’expression des gènes dans deux structures du cerveau encore peu étudiées et impliquées dans les aspects émotionnels de l’addiction (amygdale étendue centrale et hypothalamus latéral) et nous avons opté pour une stratégie à l’échelle du génome. Dans une deuxième série d’expériences, j’ai contribué à une caractérisation moléculaire de l’état d’abstinence. Dans la deuxième partie de ma thèse, j’ai étudié la contribution de la kinase RSK2 dans les réponses comportementales à la morphine in vivo. Cette kinase, potentiellement effectrice de l’activation du récepteur mu, n’a jusqu’à présent pas été étudiée dans le cadre de la toxicomanie. Nous avons étudié des souris knockout pour le gène RSK2 dans plusieurs tests permettant d’évaluer les effets de la morphine, en administration aigue ou chronique. Nos résultats suggèrent un rôle de la kinase RSK2 dans l’analgésie à la morphine et le sevrage
Drug addiction is a chronic disorder characterized by compulsive drug seeking, a loss of control over drug consumption and an important risk of relapse. Morphine is used to treat pain, and is also a drug of abuse. Morphine acts via the mu opioid receptor. In our laboratory, we are studying molecular and behavioral adaptations developing after chronic activation of the mu receptor. The aim of this thesis was to study the regulation of gene expression and intracellular pathways associated with activation of the mu receptor in vivo. A first part of my thesis addressed the transcriptional adaptations consecutive to chronic activation of the mu receptor in vivo. We used a genome-wide microarray approach to study modifications of gene expression in two brain structures (central extended amygdala and lateral hypothalamus). These brain areas have been poorly studied in the context of drug abuse, and are known to be involved in the emotional aspects of addiction. In a second set of experiments, I contributed to the molecular characterization of an abstinent state. In the second part of my thesis, I studied the implication of RSK2 kinase in behavioral responses to morphine since, a role that had never been investigated before. In order to examine the implication of RSK2 in both acute and adaptative responses to morphine, we compared several morphine effects in RSK2 deficient mice and wild-type controls. We tested morphine analgesia and tolerance, morphine locomotor sensitization, morphine physical dependence and morphine reward. Our data reveal a role of RSK2 in morphine analgesia and withdrawal
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Österberg, Yngve. "Hur förklarar Regional Security Complex Theory Mistralaffären : en undersökning gällande RSCT och försvarsmateriella handelsavbrott." Thesis, Försvarshögskolan, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-6723.

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Regional Security Complex Theory (RSCT) innefattar analysenheter som är nära kopplade till försvarsmateriella handelavtal och har därför ett teoretiskt ramverk som kan hjälpa förstå och förklara avtalen i detalj. Det är dock oklart exakt hur detta ska göras eftersom det inte tas upp i Regions and Powers: The Structure of International Security. Syftet med denna uppsats är att med hjälp av RSCT förklara Mistralaären för att sedan undersöka om det finns en underliggande process gemensamt för liknande fall.
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Books on the topic "Rsc2"

1

Gallery, RSC, and Royal Shakespeare Company, eds. RSC Gallery. Stratford upon Avon: Royal Shakespeare Theatre, 1986.

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Vanderhaeghe, Stijn. RSC Anderlecht. Lichtervelde: Uitgeverij Kannibaal bvba, 2013.

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Great Britain. Department of Health. and Great Britain. Central Office of Information., eds. Registered sick children's nurse (RSCN). [London]: [Department of Health], 1989.

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(Firm), Ian Ritchie Architects, ed. RSC Courtyard Theatre. Herne Bay: Categorical Books, 2006.

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Eoghan O Tuairisc-Na hu rsce altat. [s.l: The Author], 1986.

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Shakespeare, William. The RSC Shakespeare: Complete works. Edited by Bate Jonathan, Rasmussen Eric 1960-, and Royal Shakespeare Company. Houndmills, Basingstoke, Hamsphire: Palgrave Macmillan, 2007.

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Jackman, Richard, Oliver A. Williams, Anke Krueger, Raj Mohanty, and Emanuelle Scorsone. Nanodiamond: Rsc. Royal Society of Chemistry, The, 2014.

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Osiek, Carolyn, and Mary Blish. Anna Xavier Murphy, RSCJ. Society of the Sacred Heart, 2021.

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Myers. Solutions Manual Rsch Design 2nd. Lawrence Erlbaum Associates, 2002.

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WHITE. Instr Rsce CD Fluid Mechanics. McGraw-Hill Education, 1999.

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Book chapters on the topic "Rsc2"

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Donato, Dominique M., Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, et al. "PBAF RSC." In Encyclopedia of Signaling Molecules, 1348. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_101000.

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Spring, J., C. P. Janzen, M. Darensbourg, J. C. Calabrese, P. J. Krusic, J. N. Verpeaux, and C. Amatore. "Electrochemical Study of the Oxidation Chemistry of Chromium Carbonyl Thiolates RSCr(CO)5 - and RSCr2(CO)10 -." In Molecular Electrochemistry of Inorganic, Bioinorganic and Organometallic Compounds, 417–21. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1628-2_38.

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Holding, Peter. "Terry Hands, RSC, 1973." In Romeo and Juliet, 51–57. London: Macmillan Education UK, 1992. http://dx.doi.org/10.1007/978-1-349-11363-7_8.

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Holding, Peter. "Michael Bogdanov, RSC, 1986/7." In Romeo and Juliet, 63–68. London: Macmillan Education UK, 1992. http://dx.doi.org/10.1007/978-1-349-11363-7_10.

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Holding, Peter. "Terry Hands, RSC, 1989/90." In Romeo and Juliet, 68–73. London: Macmillan Education UK, 1992. http://dx.doi.org/10.1007/978-1-349-11363-7_11.

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Taylor, Millie. "Musical Collaborations at the RSC." In Theatre Music and Sound at the RSC, 11–49. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-95222-2_2.

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Taylor, Millie. "Collaborative Composition at the RSC." In Theatre Music and Sound at the RSC, 51–91. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-95222-2_3.

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Taylor, Millie. "Theatre Music at the RSC." In Theatre Music and Sound at the RSC, 133–73. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-95222-2_5.

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Tang, Guanjun, Yonghua Chen, Shiguang Xu, Qian Chen, and Wenchen He. "RSCM: A Reliability-Aware Service Chain Mapping." In Lecture Notes in Computer Science, 653–62. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24265-7_56.

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"Euro RSCG." In The Advertising Age Encyclopedia of Advertising, 573–83. Routledge, 2015. http://dx.doi.org/10.4324/9781315062754-55.

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Conference papers on the topic "Rsc2"

1

Bescher, Eric, John Kim, and Michael McNerney. "On the Differences in Chemistry and Performance Between Types of Rapid Strength Concretes (RSCs)." In 12th International Conference on Concrete Pavements. International Society for Concrete Pavements, 2021. http://dx.doi.org/10.33593/83main8q.

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Rapid-setting cements are used in concrete under a variety of acronyms (HES for High Early Strength concrete, or RSC for Rapid Strength Concrete, etc.). Their use is becoming increasingly important because our ageing highway and airport concrete infrastructure requires fast construction in order to minimize downtime. A simple but broad nomenclature for RSC concretes hides several important differences between materials. In some respects, there is no such thing as single RSC; there are several different types of RSCs with different mineralogies and characteristics. Specifications, appropriately so, focus on performance instead of chemical composition. One key RSC specification is early-age strength, for example 2.76 MPa (400 psi) flexural strength at 4 hours in order to re-open pavement to service. Yet, differences in materials usually result in differences in durability. For example, if only early strength is specified, what is the impact of mineralogical differences on other characteristics like freeze-thaw resistance or shrinkage? Protocols are also important: if pavement enters service at 4 hours, shouldn't a shrinkage measurement also start at 4 hours? Standard shrinkage testing protocols do not. This paper reviews the chemistry and hydration of three commercially available RSC materials (accelerated portland cement, belitic calcium sulfoaluminate cement and calcium sulfoaluminate blended with portland cement and calcium sulfates).
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Tian, Luo Hong. "Bidirectional Extreme Convergency Methods (BECM) to Identify the Mobility Regions of the RSSR Mechanism." In ASME 1992 Design Technical Conferences. American Society of Mechanical Engineers, 1992. http://dx.doi.org/10.1115/detc1992-0374.

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Abstract The BECM are proposed to classify spatial four-link mechanisms according to groups such as crank-rocker, double-rocker and double-crank (drag link). The BECM can determine the feasible regions and number of the extreme values exactly and solve them simply without complex derivation and calcultion. The paper concerns itself mainly with the RSSR linkage but it can be applied also to other types such as RSSP, RSCP, RSCR etc. The method is very simple and the geometric concept is very clear. Although the graphical methods is mainly introduced in this paper, certainly, it can also be coded in computer to solve out their accurate values.
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Zhang, Haitao, and Ke Li. "Predicting the Risk of Twist-Off for Rotary Shouldered Threaded Connections With a Statistical Approach." In ASME 2019 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/imece2019-11061.

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Abstract Fatigue is one of the most frequently encountered failure modes of rotary shouldered connections (RSC) used in drill strings. Once initiated, a fatigue crack tends to grow and ultimately lead to a twist-off, which is catastrophic and often results in lengthy non-producing time and expensive fishing operations. The complexity of the fatigue mechanism, the variabilities of material properties, and the nonlinear contact interactions of the pin and the box elements of an RSC pose a substantial challenge to accurately predicting the fatigue life of the RSC. This would require considerable conservatism to be exercised to prevent a twist-off, which causes premature retirement of drilling assets. Using a statistical approach to predict the risk of twist-off (ROTO) of each RSC on the drill string could be a more economically viable solution as it would enable quantified risk assessment and scientifically calculated tradeoffs between performance, cost, and risk of failures. In this study, a methodology for statistical prediction of the ROTO of rotary shouldered threaded connections was developed. First, static material properties, including yield strength, tensile strength, elongation, and reduction in area, were extracted from a wealth of available material certificates. Feature engineering was carried out to arrive at two independent properties, tensile strength and reduction in area. Fatigue properties were then generated with the retrieved static material data and earlier established correlations between static and fatigue properties. Afterwards, elasto-plastic finite element analyses were performed on RSCs made of the same material but with different properties to determine critical fatigue indicators, stress and strain states as respective functions of the tensile strength. Finally, Monte-Carlo simulations were conducted with respect to statistical distributions of the two independent material variables to predict the ROTO as a function of fatigue life. The predictions were found to be favorable agreement with the available full-scale fatigue test data of an API connection type.
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Nelles, L., H. R. Linjnen, E. Demarsin, D. Collen, and W. E. Holmes. "CHARACTERIZATION OF SINGLE CHAIN UROKINASE-TYPE PLASMINOGEN ACTIVATOR MUTANTS PRODUCED BY SITE-SPECIFIC MUTAGENESIS OF LYS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642909.

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A cDNA encoding full length single chain urokinase-type plasminogen activator (scu-PA) was cloned and sequenced. The recombinant scu-PA (rscu-PA) cDNA as well as the cDNA of two mutants constructed by deoxyoligonucleotide directed mutagenesis of Lys158 in rscu-PA to Gly158 (rscu-PA-Gly158 ) or to Glu158 (rscu-PA-Glu158 ) were inserted into SV40 early promoter/enhancer based expression vectors, which were used to transfect Chinese Hamster Ovary (CHO) cells. The expression products were purified from serum-free conditioned media by immunoadsorption on an insolubilized monoclonal antibody raised against natural scu-PA (nscu-PA), followed by gel filtration.The amidolytic activity of the three rscu-PAs was low (< 500 IU/mg). The mutant rscu-PAs, in contrast to the rscu-PA and nscu-PA, could not be converted into an amidolytically active two-chain form (tcu-PA) by plasmin. The mutant scu-PAs had a very low specific activity (< 1,000 IU/mg) on fibrin plates, whereas wild type rscu-PA had a specific activity < 1000 IU/mg. The mutant scu-PAs did not cause lysis of a I-fibrin labeled plasma clot immersed in citrated human plasma. Serum-free medium from a control transfected CHO cell line showed no significant plasminogen activating activity.In a purified system, both rscu-PA-Gly and rscu-PA-Glu activate plasminogen following Michaelis-Menten kinetics, with a much lower affinity (K = 60-80 yM) but with a higher catalytic rate constant (k2 = B.01 s-1) as compared to the wild type rscu-PA (K =1.0 yM, k = 0.002 s-1).It is concluded thaz conversion of scu-PA to tcu-PA is prerequisite for the activation of plasminogen. However, Lys158 seems to be important for the stability of the Michaelis complex between scu-PA and plasminogen.
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Ferraz Costa, Alceu, Yuto Yamaguchi, Agma Juci Machado Traina, Caetano Traina, and Christos Faloutsos. "RSC." In KDD '15: The 21th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2783258.2783294.

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Yu, Shengtao, Cheolkon Jung, Kailong Zhou, and Chen Su. "RSC-DGS." In MMAsia '19: ACM Multimedia Asia. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3338533.3368261.

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Morris, Jenny, Stephen Wickham, David Nicholls, Ciara Walsh, and James McKinney. "Key Differentiators Influencing the Choice of Robust Shielded Containers." In ASME 2013 15th International Conference on Environmental Remediation and Radioactive Waste Management. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icem2013-96331.

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The NDA’s Upstream Optioneering project has examined the potential implications of using an alternative type of waste package and its influence on the waste management lifecycle across the NDA estate. Robust Shielded Containers (RSCs) are radioactive waste packages that provide integral radiological shielding, reducing the need for remote handling. The robustness of the container could remove the need to immobilise waste by cement encapsulation. RSCs are routinely used to package ILW for interim storage in Germany and have fairly recently been considered for use in the UK because RSCs have the potential to simplify the waste management lifecycle and enable risk and hazard reduction. In particular, the current baseline (included in Magnox Limited lifetime plans) follows the strategy set out in the Magnox Operating Decommissioning Programme (MODP), in which Type II MOSAIK and Type VI Ductile Cast Iron Containers (DCICs) are used to package (in non-encapsulated form) most Magnox ILW arising prior to 2050. By considering representative types of Intermediate Level Waste (ILW) and exploring potential packaging options for these wastes, this paper identifies the factors that could differentiate between cases in which RSCs would, or would not, be an appropriate option. The potential role of RSCs across the waste management lifecycle is examined, from retrieval of waste through to emplacement at a Geological Disposal Facility (GDF), including consideration of other potential uses of RSCs, such as temporary storage of raw wastes for which appropriate treatment and conditioning measures have yet to be developed.
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Kumar, Manish, and Jyoti Saxena. "Performance Comparison of RSC-RSC and RS-RSC Concatenated Codes Using Non-iterative Concatenated Viterbi Decoding Technique." In 2013 International Conference on Machine Intelligence and Research Advancement (ICMIRA). IEEE, 2013. http://dx.doi.org/10.1109/icmira.2013.96.

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Darter, Michael. "Long-Term Performance of Jointed Plain Concrete Pavement with Rapid Strength Concrete On California Highways." In 12th International Conference on Concrete Pavements. International Society for Concrete Pavements, 2021. http://dx.doi.org/10.33593/2rh2xidw.

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Rapid Strength Concrete (RSC) slabs on six California jointed plain concrete pavement (JPCP) highway projects were surveyed. These projects had been previously surveyed in 2008 at 3-years of age and by 2018 had reached a service life of 13-years. Of the initial 5430 slabs examined in 2008, a total of 1493 RSC slabs, located on 12 traffic lanes, were observed and distress types recorded again in 2018. These slabs included both CTS and 4x4 RSC located in both inner and outer lanes. Only a small percentage (1.4%) of the 5,430 RSC slabs exhibited any distress in 2008 after 3-years' service and the increases were small over the next 10 years of service with the exception of transverse fatigue cracks. The transverse (top down fatigue) type of cracking had the highest percentage and largest increase of any distress type. The heavy truck outside lanes exhibited 21% transversely cracked RSC slabs and the inner passing lanes 3%. The outer truck lanes carried over 3 times more trucks than inner lanes. The RSC slabs were mostly 200-223 mm thick and thus susceptible to fatigue damage. The overall performance of the RSC slabs (both CTS and 4x4 RSC materials) were similar and considered to be outstanding over 13 years with a large majority expected to survive many more years.
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Abrams, Richard F., and Robert Faia. "RSCR® System to Reduce NOx Emissions From Boilers." In 17th Annual North American Waste-to-Energy Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/nawtec17-2363.

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Babcock Power Environmental (BPE), a Babcock Power Inc. company, has developed a new, innovative, high-efficiency NOx reduction technology designed to greatly reduce the NOx emissions from waste to energy (WTE) boilers at relatively low cost. This “tail-end” system uses Selective Catalytic Reduction (SCR) to achieve the high reduction performance. Conventional SCR catalyst cannot be used in the traditional “high-dust” location, downstream of the economizer because constituents in the ash would poison the catalyst quickly, rendering it useless. Thus, the Regenerative Selective Catalytic Reduction (RSCR®) system is designed to operate at the end of the plant before the flue gas is discharged to the stack. The process utilizes a reactant (usually aqueous ammonia) to be added to the flue gas stream upstream of the RSCR to reduce NOx to harmless reaction products, N2 and H2O. The RSCR combines the efficient heat recovery, temperature control, reactant mixing, and catalyst into a single unit and provides the maximum NOx reduction and heat recovery practical. The paper will describe the overall predicted performance of a typical WTE boiler plant using this new technology. The paper will also provide actual operating data on the RSCR, which has been retrofitted to four biomass-fired units.
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Reports on the topic "Rsc2"

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Argandoña, Antonio, and Sergio Marín García. Filantropía y RSC. Servicio de Publicaciones de la Universidad de Navarra, 2018. http://dx.doi.org/10.15581/018.st-487.

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Fontrodona, Joan, and Sergio Marín. Sostenibilidad y RSC. Servicio de Publicaciones de la Universidad de Navarra, May 2019. http://dx.doi.org/10.15581/018.st-514.

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Snijders, J., T. Harrison, and B. Maddison. A Profile for RPKI Signed Checklists (RSCs). RFC Editor, November 2022. http://dx.doi.org/10.17487/rfc9323.

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DeSanti, C., H. K. Vivek, K. McCloghrie, and S. Gai. Fibre Channel Registered State Change Notification (RSCN) MIB. RFC Editor, August 2007. http://dx.doi.org/10.17487/rfc4983.

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Семеріков, С. О., and А. М. Стрюк. Розробка плагінів для експорту з OJS до RSCI. ЧДТУ, May 2018. http://dx.doi.org/10.31812/0564/2244.

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Формалізований облік продуктивності науковця за опублікованими результатами – важлива складова оцінки його діяльності, діяльності наукових підрозділів та установ – виконується за допомогою наукометричних баз даних. Головним джерелом відомостей про публікації є їх анотації та інші метадані, розміщувані на сайті наукового журналу під управлінням відповідної системи підтримки електронного документообігу, провідною з яких є Open Journal Systems (OJS). Ураховуючи, що стандартний метод експорту з OJS до наукометричної бази даних Russian Science Citation Index (RSCI) відсутній, була виконана розробка нового плагіну експорту із OJS 3 до системи підготовки випусків Articulus.
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Lannigan, Deborah A. The Protein Kinase, RSK2, A Novel Drug Target for Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, May 2005. http://dx.doi.org/10.21236/ada437856.

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Barrio Fraile, E., AM Enrique Jiménez, and J. Benavides Delgado. El proceso de gestión de la RSC. Estudio de caso. Revista Latina de Comunicación Social, September 2017. http://dx.doi.org/10.4185/rlcs-2017-1208.

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MOSKALENKO, O. L., R. A. YASKEVICH, and E. V. KASPAROV. METABOLIC SYNDROME: PREVALENCE, DIAGNOSIS CRITERIA. Science and Innovation Center Publishing House, April 2022. http://dx.doi.org/10.12731/978-0-615-67340-0-3.

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This article presents a review of the literature and analyzes scientific research on the metabolic syndrome and diagnostic criteria. The authors conducted a scientific search using the relevant keywords in the PubMed and Google Scholar search engines, in the Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka, RSCI and others databases.
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MOSKALENKO, O. L., S. YU TERESHCHENKO, and E. V. KASPAROV. INTERNET ADDICTION: DIAGNOSIS CRITERIA AND METHODS. Science and Innovation Center Publishing House, April 2022. http://dx.doi.org/10.12731/978-0-615-67340-0-2.

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This article presents a review of the literature and analyzes scientific studies on the prevalence of Internet addiction in different countries. The authors conducted a scientific search using the relevant keywords in the PubMed and Google Scholar search engines, in the Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka, RSCI and others databases.
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Gaponenko, Artiom, and Vitaly Gaponenko. Site «Gaponenko Artiom Vasilievich – autobiography and results of scientific and pedagogical activity». Science and Innovation Center Publishing House, April 2021. http://dx.doi.org/10.12731/www.gaponenko.info.

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The site of Artiom Vasilyevich Gaponenko (https://www.gaponenko.info/) is intended to give a holistic view of the personality and the results of the scientific and pedagogical activity of the author. The site contains an autobiography, a list of scientific and pedagogical works, a link to the developed educational system MLESYS (https://mlesys.ru/), as well as information about advanced training, professional retraining and participation of A.V. Gaponenko. in competitions. At the bottom of the site page there is a personal Science Index counter (RSCI), there is a link to the author's portfolio.
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