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Dissertations / Theses on the topic 'Ross River Virus'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Rulli, Nestor Ezequiel. "Ross River virus infection : mechanisms and potential treatment /." full text available via ADT, 2007. http://erl.canberra.edu.au/public/adt-AUC20080227.091948/index.html.

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2

Rulli, Nestor Ezequiel, and na. "Ross River Virus Infection: Disease Mechanisms and Potential Treatment." University of Canberra. School of Health Sciences, 2007. http://erl.canberra.edu.au./public/adt-AUC20080227.091948.

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Ross River virus (RRV) is a mosquito-borne alphavirus and the aetiological agent of epidemic polyarthritis (EPA). Arthropod borne-Alphaviruses that are related to RRV, such as Chikungunya virus, Sindbis virus and Barmah Forest virus, are usually associated with epidemics of infectious arthritides in different parts of the world. In humans, RRV-induced disease symptoms include fever, rash, myalgia and pain and stiffness of the joints. Muscle and joint pain are the most debilitating symptoms in RRV patients and the best treatment available is non-steroidal anti-inflammatory drugs (NSAID). Previo

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3

Choi, Yoon-Hong. "The mathematical modelling of the Ross River Virus transmission." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 1997. https://ro.ecu.edu.au/theses/896.

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Ross River virus is one of the most severe communicable diseases in Australia. During the 1995/96 outbreak of Ross River virus in south-western Australia, over 1 ,300 human cases were reported. Since the symptoms of the disease are sometimes too weak to be diagnosed, it is important to determine the number of humans who actually contracted the virus during outbreaks. To do this, several mathematical models with different hypotheses are constructed and analysed mathematically. The threshold mathematical conditions of these models suggest that as well as the size of the vector mosquito populatio

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4

Prow, Natalie A. "Epidemiology of Ross River virus in the south-west of Western Australia and an assessment of genotype involvement in Ross River virus pathogenesis." University of Western Australia. Microbiology and Immunology Discipline Group, 2006. http://theses.library.uwa.edu.au/adt-WU2006.0132.

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[Truncated abstract] Ross River virus (RRV) causes the most common arboviral disease in Australia, with approximately 5000 new cases reported each year, making this virus a major public health concern. The aim of this thesis was to link results from virological, pathogenesis and epidemiological studies to further define RRV disease in the south-west (SW) of Western Australia (WA), a region of endemic and epizootic RRV activity. A crosssectional seroprevalence study was used to show that 7.8 percent of SW communities were seropositive to RRV, comparable to other regions of Australia with simila

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5

Zaid, Ali, and n/a. "IMMUNE EVASION AND DISEASE MECHANISMS IN ROSS RIVER VIRUS INFECTION." University of Canberra. Biomedical Sciences, 2008. http://erl.canberra.edu.au./public/adt-AUC20091216.122508.

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Ross River virus (RRV) is an Alphavirus distributed throughout Australia. It is transmitted by mosquitoes and is known to cause moderate to severe disease symptoms in humans. Along with other alphaviruses such as Sindbis virus and Chikungunya virus, RRV is known to cause arthritic symptoms, characterised by muscle and joint inflammation. Several investigations have established the role of macrophage cells and pro-inflammatory host factors in the development of RRV-induced disease. In this study, we attempted to determine differences between RRV passaged in mammalian and mosquito cells. There i

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6

Liu, Xiang. "Ross River Virus Interaction with the Type I IFN Pathways." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367506.

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Ross River virus (RRV) belongs to the genus Alphavirus and is a medically important arbovirus that causes musculoskeletal disease in humans with symptoms such as arthralgia, arthritis and myalgia. Disease symptoms consistent with RRV infection were first recorded in 1928 in Australia. Currently, with approximately 5,000 cases of RRV infection reported each year in Australia, RRV is the most widely spread arbovirus throughout the South Pacific region. At present there are no specific therapeutics or vaccines available. RRV disease is treated with analgesics and non-steroidal anti-inflammatory d

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7

Horne, Felicity Anne. "Consequences of an in utero Ross River virus in mice." Thesis, Queensland University of Technology, 1997. https://eprints.qut.edu.au/36998/1/36998_Horne_1997.pdf.

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The physical and immunological consequences to BALB/c and CBA murine neonates of in utero infection with Ross River virus [RRV] were compared to previously reported teratogenic and tolerogenic properties of other togaviruses. X-ray imaging as a means of determining the incidence, type and extent of teratogenesis induction in neonatal mice lacked sufficient resolution for the determination of structural abnormalities. A previously described histological technique for identifying cartilage and bone defects [Mabruk et al., 1988] was unsatisfactory as disintegration of neonatal material oc

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8

Carver, Scott Stevenson. "Dryland salinity, mosquitoes, mammals and the ecology of Ross River virus." University of Western Australia. School of Animal Biology, 2008. http://theses.library.uwa.edu.au/adt-WU2009.0100.

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[Truncated abstract] In an era of emerging and resurging infectious diseases, understanding the ecological processes that influence pathogen activity and the influences of anthropogenic change to those are critical. Ross River virus (RRV, Togoviridae: Alphavirus) is a mosquito-borne zoonosis occurring in Australia with a significant human disease burden. In the southwest of Western Australia (WA) RRV is principally vectored by Aedes camptorhynchus Thomson (Diptera: Culicidae), which is halophilic. The inland southwest, the Wheatbelt region, of WA is substantially affected by an anthropogenic s

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9

Ratnayake, Jayalath Tikiri Bandara. "The Valuation of Social and Economic Costs of Mosquito-Transmitted Ross River Virus." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/367397.

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Insect pests (such as mosquitoes) and their associated impacts have become important social, economic and environmental health issues. Mosquitoes transmit diseases, are widely perceived as a nuisance and are becoming a serious health concern for the public. The incidence of contracting mosquito-transmitted diseases has markedly increased in recent decades in Australia (Russell 1994). Currently, Ross River virus is the most prevalent mosquito-transmitted viral disease in Australia with up to 8,000 cases reported annually (Curran et al. 1996). The absence of documented evidence about the full so

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10

Hu, Wenbiao. "Applications of Spatio-temporal Analytical Methods in Surveillance of Ross River Virus Disease." Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16109/1/Wenbiao_Hu_Thesis.pdf.

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The incidence of many arboviral diseases is largely associated with social and environmental conditions. Ross River virus (RRV) is the most prevalent arboviral disease in Australia. It has long been recognised that the transmission pattern of RRV is sensitive to socio-ecological factors including climate variation, population movement, mosquito-density and vegetation types. This study aimed to assess the relationships between socio-environmental variability and the transmission of RRV using spatio-temporal analytic methods. Computerised data files of daily RRV disease cases and daily climatic

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11

Hu, Wenbiao. "Applications of Spatio-temporal Analytical Methods in Surveillance of Ross River Virus Disease." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16109/.

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The incidence of many arboviral diseases is largely associated with social and environmental conditions. Ross River virus (RRV) is the most prevalent arboviral disease in Australia. It has long been recognised that the transmission pattern of RRV is sensitive to socio-ecological factors including climate variation, population movement, mosquito-density and vegetation types. This study aimed to assess the relationships between socio-environmental variability and the transmission of RRV using spatio-temporal analytic methods. Computerised data files of daily RRV disease cases and daily climatic

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12

Back, Chelsea. "Induction of programmed cell death in mammalian cells by isolates of Ross River virus." Thesis, Back, Chelsea (2011) Induction of programmed cell death in mammalian cells by isolates of Ross River virus. Honours thesis, Murdoch University, 2011. https://researchrepository.murdoch.edu.au/id/eprint/11832/.

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Arthritogenic alphaviruses, such as Ross River virus (RRV) are associated with worldwide outbreaks of human polyarthritis/arthralgia. The pathogenesis of RRV and other alphaviruses is poorly understood. Studies have shown potential links between the different strains of RRV and variation in their pathogenesis and virulence. Currently there is believed to be two circulating strains of RRV, the south western (SW) from the south west region of Western Australia and the north eastern (NE) from the east coast of Australia. Studies have suggested that the persistence of RRV may be the result of an i

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13

Mostafavi, Helen. "A Novel Role of IL-17+ Cell Subsets in Ross River Virus-Induced Arthritic Disease." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/370989.

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Arthritogenic alphaviruses such as Ross River virus (RRV) and Chikungunya virus (CHIKV) are mosquito-borne viruses that have been responsible for outbreaks of arthritic disease in Australia and worldwide, respectively. Characteristic disease of arthritogenic alphaviruses include the development of joint inflammation and arthritic disease which can last months to years after infections. Arthritic disease caused by RRV and CHIKV shares similar characteristics with rheumatoid arthritis (RA), such as the development of incapacitating, joint inflammation, as well as the upregulation of proinflammat

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14

Stephenson, Eloise. "Understanding the ecology of Ross River virus; novel approaches and insights into non-human reservoirs." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/389694.

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Arboviruses contribute a significant burden to human and animal health. Circulation of arboviruses comprises three components; blood-sucking arthropods, vertebrate hosts, and viruses that can infect vertebrates and invertebrates. Interaction of these components is dependent on ecological factors (such as species distributions and climate), epidemiological factors (including vector and host immunity) and behavioural determinants (such as vector feeding host preference or host defensive behaviours). Identifying these drivers of disease emergence can be complicated but informs efforts to mitigate

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15

Supramaniam, Aroon. "Characterising Heparan Sulfate Mimetics as Potential Therapeutics in Alphaviral Diseases." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/389702.

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Arthritogenic alphaviruses such as chikungunya virus (CHIKV) and Ross River virus (RRV) are transmitted by mosquito vectors, and can cause musculoskeletal disease manifestations such as, excruciating pain and inflammation in joints and the surrounding muscle tissues, in infected individuals. Despite the recent findings of cartilage damage, erosion and focal necrosis in murine models of both chikungunya viral disease (CHIKVD) and Ross River viral disease (RRVD), the role of human chondrocyte/cartilage in alphaviral infection has never been previously explored. In this thesis, it was shown that,

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16

Murphy, Amanda. "Eco-epidemiology of dengue and Ross River viruses across rural and urban environments." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/204283/1/Amanda_Murphy_Thesis.pdf.

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This research investigated the epidemiology and ecology of two mosquito-borne viruses of public health importance in the Asia-Pacific: dengue and Ross River viruses. Patterns of disease caused by these two viruses were analysed in space and time across rural and urban settings, and some of the influencing demographic, geographic and environmental factors were explored. The outcomes of this research included increased understanding of the complex influences on mosquito-borne virus transmission in different human habitats, and the development of unique field and lab-based approaches for studying

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17

Tomerini, Deanna Majella. "The Impact of Local Government Mosquito Control Programs on Ross River Virus Disease in Queensland, Australia." Thesis, Griffith University, 2008. http://hdl.handle.net/10072/366893.

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In this study, I have investigated the relationship between mosquito control and mosquito-borne disease rates within Queensland, Australia. The thesis considers the most prevalent arbovirus causing human disease in Australia (Ross River virus) and estimates, how much Ross River virus disease is avoided through local government mosquito control in Queensland, and then compares the monetary value of avoided Ross River virus disease with the financial costs of local government mosquito control. A survey to collect information about mosquito control costs and practices was designed and implemented

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18

Jardine, Andrew. "The impact of dryland salinity on Ross River virus in south-western Australia : an ecosystem health perspective." University of Western Australia. School of Population Health, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0182.

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[Truncated abstract] A functional ecosystem is increasingly being recognised as a requirement for health and well being of resident human populations. Clearing of native vegetation for agriculture has left 1.047 million hectares of south-west Western Australia affected by a severe form of environmental degradation, dryland salinity, characterised by secondary soil salinisation and waterlogging. This area may expand by a further 1.7-3.4 million hectares if current trends continue. Ecosystems in saline affected regions display many of the classic characteristics of Ecosystem Distress Syndrome (E

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19

Foo, Suan Sin. "Deciphering the Role of Macrophage Subsets and Macrophage-Derived Factors During Arthrogenic Alphaviral Infection." Thesis, Griffith University, 2015. http://hdl.handle.net/10072/365249.

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The current situation of global warming has a serious impact on the control of arthropod-borne infectious diseases. Climate change has led to an increase in conducive breeding habitats for mosquitoes. This change in climate has contributed to the widespread distribution of mosquito-transmitted arthritogenic alphaviruses such as Ross River virus (RRV) and chikungunya virus (CHIKV). RRV is currently endemic to Australia and Papua New Guinea, while CHIKV causes global outbreaks. The recent CHIKV outbreak in the Americas has taken the world by surprise and has affected more than 1 million individu

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20

Wells, Peter J. "Vector competence of aedes vigilax (Skuse) and culex annulirostris Skuse (Diptera:Culicidae) for Ross River virus, and some other alphaviruses and bunyaviruses." Thesis, The University of Sydney, 1994. https://hdl.handle.net/2123/27471.

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21

Lee, Wai Suet. "Discovery of Novel Markers of Virus Transmission by Mosquitoes." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/390018.

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Mosquito-borne diseases are responsible for significant human morbidity and mortality throughout the world. Current vector control strategies have been impeded by mosquitoes acquiring resistance to insecticide. Therefore, development of new vector control strategies is urgently needed to complement current strategies. In this thesis, efforts have focused on characterizing the glycan-lectin interactions of Ross River virus (RRV; Togaviridae: Alphavirus) with their mosquito vectors. RRV is the most common arbovirus in Australia that causes clinical manifestations including arthralgia and myalgia

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22

Boyd, Ann Marie. "Interactions between common vertebrate hosts and the mosquito vectors of Ross River and Barmah Forest viruses in urban Brisbane, South East Queensland, Australia /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18059.pdf.

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23

Ralambondrainy, Miora. "Caractérisation chimique et biologique de trois huiles essentielles répulsives issues de la biodiversité régionale contre l'alphavirus du Ross River." Thesis, La Réunion, 2017. http://www.theses.fr/2017LARE0018/document.

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Les huiles essentielles de citronnelle (Cymbopogon citratus), de géranium (Pelargonium graveolens) et de vétiver (Vetiveria zizanioides) sont utilisées partout dans le monde pour leur activité répulsive contre les principaux vecteurs (moustiques, tiques) de maladies infectieuses chez l'Homme (paludisme, chikungunya, …). L'application cutanée de ces produits naturels pour éviter le contact avec un vecteur n'avait pas été encore envisagée comme moyen de limiter les premiers stades de l’infection par l'agent pathogène transmis par le vecteur. Pour vérifier cette hypothèse, les travaux ont été con

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24

Wolf, Stefan. "Novel Approaches in the Treatment of Virus- Induced Inflammatory Disease." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/366853.

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This PhD thesis combines four chapters on different fields of basic research and sets the focus on two circulating viruses of global concern, the orthomyxovirus influenza A virus (IAV) and the alphavirus Ross River virus (RRV). The first three chapters include swine influenza A virus (sIAV) surveillance for the detection and characterisation of IAV subtypes, an in vitro high throughput screening (HTS) on host micro RNAs (miRNAs) for the discovery of novel anti-IAV (H7N9) targets and their underlying mechanisms, and an approach to reduce disease pathogenesis in mice infected with H7N9 by target

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25

Chen, Weiqiang. "The Interplay between Alphaviral Infection and Inflammatory Arthritis." Thesis, Griffith University, 2015. http://hdl.handle.net/10072/367986.

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Arthritogenic alphaviruses such as Ross River virus (RRV) and chikungunya (CHIKV), Sindbis-like viruses (SINV), Barmah Forest virus (BFV), ) Mayaro virus (MAYV) and o’nyong-nyong virus (ONNV) are responsible for outbreaks of debilitating rheumatic joint disease during infection. CHIKV is typically notorious in central Africa, India, South-East Asia and Europe, while other alphaviruses such as RRV and BFV are endemic to Australia. In Australia, there are approximately 4000 cases of RRV reported annually, while the number of CHIKV cases continues to rise in epidemic regions. In 2014, CHIKV invad

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26

Woodruff, Rosalie Ellen. "Climate and environment as signal predictors of Ross River virus disease." Phd thesis, 2003. http://hdl.handle.net/1885/148805.

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27

Meek, Andrew D. J. "Genetic and phenotypic studies on virulence variants of Ross River virus." Phd thesis, 1986. http://hdl.handle.net/1885/144142.

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28

Koolhof, IS. "Epidemiological forecasting and the ecology of Ross River virus across Australia." Thesis, 2022. https://eprints.utas.edu.au/47468/1/Koolhof_whole_thesis.pdf.

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Understanding the epidemiological mechanisms that drive disease incidence and forecasting incidence are major goals in public health. This is particularly relevant for mosquito-borne pathogens that cause human disease burden. In terms of incidence, Australia’s most epidemiologically important mosquito-borne diseases is the Ross River virus (RRV, Togoviridae: Alphavirus). Ross River virus disease occurs widely across Australia with a significant burden to human health through epizootic spillover. Owing to its notifiable status, there is high-quality national health surveillance. In this thesis,

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29

Kerr, Peter J. "Biological and genetic studies on the E2 glycoprotein of Ross River virus." Phd thesis, 1990. http://hdl.handle.net/1885/143120.

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30

Faragher, Susan G. "Sequence studies on natural and laboratory-derived virulence variants of Ross River virus." Phd thesis, 1987. http://hdl.handle.net/1885/142636.

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31

Ng, Victoria. "Developing predictive models for Ross River virus disease in New South Wales, Australia." Phd thesis, 2011. http://hdl.handle.net/1885/264578.

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Introduction: This thesis presents research undertaken to assess the possibility of using data on climate, environment and the Ross River virus (RRV) vector and host species to develop early warning predictive models for RRV disease in New South Wales, Australia. Such models may then contribute to the anticipation, prevention and control of RRV disease. Background: Mosquito-borne diseases at the national and global levels are a substantial cause of morbidity and mortality. There are currently few vaccines available for mosquito-borne diseases (yellow fever and Japanese encephal

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32

Vrati, Sudhanshu. "Genetic and biological studies on laboratory-derived and natural isolates of Ross River virus." Phd thesis, 1986. http://hdl.handle.net/1885/143158.

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33

(9875828), PJ Lowe. "Prevalence and diagnosis of the etiologic agents of pyrexia of unknown origin in the Central Queensland Region." Thesis, 1994. https://figshare.com/articles/thesis/Prevalence_and_diagnosis_of_the_etiologic_agents_of_pyrexia_of_unknown_origin_in_the_Central_Queensland_Region/13426835.

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Pyrexia is an illness of unknown origin where people suffer unexplained fevers, headaches and fatigue. This study was undertaken to ascertain the prevalence of agents which may be associated with pyrexia in the Central Queensland region. Illnesses researched include Ross River Virus, Leptospirosis, Barmah Forest Virus, Brucellosis, Lyme Borrelosis and Streptococcal infections. A study was undertaken to ascertain the prevalence of agents which may be associated with pyrexia in the Central Queensland region. Five hundred and twenty four patient sera submitted to the laboratory from January 1991

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34

Zhang, Ying. "The relationship between climate variation and selected infectious diseases: Australian and Chinese perspectives." 2007. http://hdl.handle.net/2440/40404.

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Background Climate variation has affected diverse physical and biological systems worldwide. Population health is one of the most important impacts of climate variation. Although the impact of climate variation on infectious diseases has been of significant concern recently, the relationship between climate variation and infectious diseases, including vector-borne diseases and enteric infections, needs greater clarification. Australia is grappling with developing politically acceptable responses to global warming. In China, few studies have been conducted to examine the effect of climate varia

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