Academic literature on the topic 'Rosmarinus officinali'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Rosmarinus officinali.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "Rosmarinus officinali"
1
Li, Guopeng, Claudio Cervelli, Barbara Ruffoni, Alona Shachter, and Nativ Dudai. "Volatile diversity in wild populations of rosemary ( Rosmarinus officinali s L.) from the Tyrrhenian Sea vicinity cultivated under homogeneous environmental conditions." Industrial Crops and Products 84 (June 2016): 381–90. http://dx.doi.org/10.1016/j.indcrop.2016.02.029.
Full text
2
Zhang, Ying, Xiaoqiang Chen, Lei Yang, Yuangang Zu, and Qi Lu. "Effects of rosmarinic acid on liver and kidney antioxidant enzymes, lipid peroxidation and tissue ultrastructure in aging mice." Food & Function 6, no. 3 (2015): 927–31. http://dx.doi.org/10.1039/c4fo01051e.
Full text
3
Тохсырова (Tokhsirova), Залина (Zalina) Маирбековна (Mairbekovna), Иван (Ivan) Викторович (Viktorovich) Попов (Popov), and Ольга (Ol'ga) Ивановна (Ivanovna) Попова (Popova). "THE STUDY OF PHENOLIC COMPOUNDS THE LEAVES AND SHOOTS OF ROSEMARY (ROSMARINUS OFFICI-NALIS L.), INTRODUCED IN BOTANICAL GARDEN OF PYATIGORSK MEDICAL-PHARMACEUTICAL INSTITUTE." chemistry of plant raw material, no. 3 (March 27, 2018): 199–207. http://dx.doi.org/10.14258/jcprm.2018033733.
Full textAbstract:
The object of the study was the leaves and shoots of rosemary medicinal (Rosmarinus officinalis L.), introduced for 9 years in the conditions of Caucasian Mineral Waters (North Caucasus) in the Botanical garden of the Pyatigorsk medical and pharmaceutical Institute in the open ground with shelter for the winter. Preliminary identification of phenolic compounds in the extracts from leaves and shoots of rosemary were carried out by thin-layer chromatography (TLC), and found gallic acid, rosmarinic acid, quercetin and apigenin.The method of high-performance liquid chromatography (HPLC) at wavelengths of 254 and 330 nm in leaves and shoots rosemary drug found 10 compounds: flavonoids: catechin, epicatechin, quercetin, apigenin; phenolcarboxylic acids: caffeic, gallic, chlorogenic, ferulic, rosmarinic as well as ascorbic acid. The content of rosmarinic acid in terms of dry raw materials in rosemary leaves was 0.181–0.184%; in shoots 0.062–0.064%.The area of the Northern Caucasus can be considered as a promising area for cultivation of medicinal plants – rosemary medicinal (Rosmarinus officinalis) – for the production of medicinal plant raw materials with a high content of biologically active substances.
4
Chaul, Luiza Toubas, Virgínia Farias Alves, Stone de Sá, Leandra de Almeida Ribeiro Oliveira, Tatiana de Sousa Fiuza, Ieda Maria Sapateiro Torres, Edemilson Cardoso da Conceição, and José Realino de Paula. "Antimicrobial Activity an Physicochemical Characterization of Extracts and Fractions of Rosmarinus officinalis and Origanum vulgare." Fronteiras: Journal of Social, Technological and Environmental Science 11, no. 1 (April 29, 2022): 8–30. http://dx.doi.org/10.21664/2238-8869.2022v11i1.p8-30.
Full textAbstract:
Rosmarinus officinalis L. (Lamiaceae) is a shrubby woody with bittersweet taste, used in chips, broths, desserts, cookies, jams, fruit salads, and marmalades. Origanum vulgare L. (Lamiaceae) is a small plant used in meats, salads, soups, rice, potatoes and boiled eggs, as well as for perfuming and flavoring oils. Both have medicinal and aromatic properties. The aims of this study were: characterize, standardize herbal drugs, crude ethanol extracts and concentrated extracts of R. officinalis and O. vulgare, determine the polyphenols, tannins, flavonoids content; quantify the rosmarinic acid; evaluate the antimicrobial activity of rosmarinic acid, extracts, fractions of R. officinalis and O. vulgare against foodborne and clinical strains. The antimicrobial activity was evaluated by the broth microdilution method. The hexane and dichloromethane fractions of R. officinalis and O. vulgare and rosmarinic acid exhibited good inhibitory activity against some Gram-positive bacteria and food isolates. Ethyl acetate fraction of R. officinalis, concentrated extract, and fractions of O. vulgare and rosmarinic acid presented good inhibitory activity against Cryptococcus. These fractions have promising potential in the control of food pathogens and they can be used in the future as an alternative natural preservative in the industry.
5
Elansary, Hosam O., Agnieszka Szopa, Paweł Kubica, Halina Ekiert, Diaa O. El-Ansary, Fahed A. Al-Mana, and Eman A. Mahmoud. "Saudi Rosmarinus officinalis and Ocimum basilicum L. Polyphenols and Biological Activities." Processes 8, no. 4 (April 10, 2020): 446. http://dx.doi.org/10.3390/pr8040446.
Full textAbstract:
Investigating the polyphenolic profile of natural Rosmarinus officinalis and Ocimum basilicum populations may reveal essential compounds that have biological activities. Natural populations of R. officinalis and O. basilicum in Northern Riyadh were investigated by HPLC-DAD analyses. Several polyphenols, including rosmarinic acid, gentisic acid, 3,4-dihydroxyphenylacetic acid, rutoside, and others, out of 38 screened were confirmed. Rosmarinic acid was the major polyphenol in both of R. officinalis and O. basilicum. R. officinalis methanolic leaf extracts contained other phenols such as gentisic acid while O. basilicum contained also 3,4-dihydroxyphenylacetic acid and rutoside as well as others. R. officinalis showed higher antioxidant activities than O. basilicum using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and β-carotene bleaching assays. These higher activities are associated with a higher composition of rosmarinic acid in leaf extracts. The antioxidant activities of O. basilicum were attributed to identified phenols of rosmarinic acid, 3,4-dihydroxyphenylacetic acid, and rutoside. There were antiproliferative and cytotoxic activities of leaf extracts, as well as identified polyphenols, against several cancer cells. These activities were attributed to the accumulation of necrotic and apoptotic cells in treated cancer cells with leaf extracts as well as identified polyphenols. The antibacterial and antifungal activities of leaf extracts were mainly attributed to 3,4-dihydroxyphenylacetic acid and rutoside in O. basilicum and rosmarinic acid and caffeic acid in R. officinalis. This study proved that R. officinalis and O. basilicum natural populations might be considered as promising sources of natural polyphenols with biological activities.
6
Kompelly, Akshay, Swathi Kompelly, Bakshi Vasudha, and Boggula Narender. "Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity." Journal of Drug Delivery and Therapeutics 9, no. 1 (January 15, 2019): 323–30. http://dx.doi.org/10.22270/jddt.v9i1.2218.
Full textAbstract:
Herbal medicine is one of the oldest valuable bestowals that were given to mankind. Many plants and herbs hold their prestigious position in the field of medicine. The worldwide interest in the use of medicinal plants has been growing, and its beneficial effects being rediscovered for the development of new drugs. Based on their vast ethnopharmacological applications, which inspired current research in drug discovery, natural products can provide new and important leads against various pharmacological targets. This work pioneers an extensive and an updated literature review on the current state of research on Rosmarinus officinalis L., elucidating which compounds and biological activities are the most relevant. According to these references, there has been an increasing interest in the therapeutic properties of this plant, regarding carnosic acid, carnosol, rosmarinic acid and the essential oil. The present manuscript provides an updated review upon the most reported activities on R. officinalis and its active constituents. This knowledge about the medicinal plants usage can also be extended to other fields like field of pharmacology. In view of the nature of the plant, more research work can be done on humans so that a drug with multifarious effects will be available in the future market.
Keywords: Rosmarinus officinalis, phytochemicals, carnosic acid, rosmarinic acid, neuroprotective activity, anti-diabetic activity.
7
Sik, Beatrix, Erika Hanczné Lakatos, Viktória Kapcsándi, Rita Székelyhidi, and Zsolt Ajtony. "Investigation of the long-term stability of various tinctures belonging to the lamiaceae family by HPLC and spectrophotometry method." Chemical Papers 75, no. 11 (July 2, 2021): 5781–91. http://dx.doi.org/10.1007/s11696-021-01755-z.
Full textAbstract:
AbstractThe aim of the current study was to analyze the stability of rosmarinic acid in ethanolic tinctures of lemon balm (Melissa officinalis L.), oregano (Origanum vulgare L.), peppermint (Mentha x piperita), rosemary (Rosmarinus officinalis L.), sage (Salvia officinalis L.), and thyme (Thymus vulgaris L.). High-performance liquid chromatography with diode-array detection (HPLC–DAD) was employed to monitor the concentration of the marker compound over a six month period. Furthermore, the tinctures were also evaluated for caffeic acid, total phenolic content, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. We observed that the concentration of rosmarinic acid in tincture stored in closed amber glasses at ambient temperature decreased significantly during 6-month storage. Furthermore, our study squarely confirms the fact that a part of rosmarinic acid is converted to caffeic acid. The tested tinctures can be listed in the following order according to the greatest stability of the marker compound: rosemary > peppermint > oregano > lemon balm > thyme > sage. The results of the study indicated a linear relationship between DPPH values and total phenolic (R2 = 0.92) or rosmarinic acid (R2 = 0.85) contents.
8
El-Naggar, Hany M., Paul E. Read, and Susan L. Cuppett. "(292) The Effect of Darkness and Sucrose Concentrations on the Production of Rosmarinic Acid in the Callus of Five Rosemary Genotypes." HortScience 41, no. 4 (July 2006): 1078B—1078. http://dx.doi.org/10.21273/hortsci.41.4.1078b.
Full textAbstract:
Rosemary Rosmarinus officinalis is a member of the Lamiaceae. Rosmarinic acid (RA) is a very strong antioxidant produced in the chloroplast, and used to protect plant tissues against oxidative stress. A number of investigations showed that the sucrose concentration in the callus growing medium greatly influenced the production of secondary metabolites of the phenylpropanoid pathway such as RA. The aim of this study was to test the effect of elevated sucrose concentrations (2%, 3%, 4%, 5%, and 6% sucrose) and the effect of light and dark treatments on the production of RA in the callus of five different genotypes. The genotypes were Majorca, Rosmarinus officinalis, Pine Scented, Madeline Hill, and APR. It was found that the dark treatment produces more RA than the light treatment in all genotypes, and in all sucrose concentrations. The RA concentration increased with increasing the sucrose concentration from 2%—reaching the highest concentration at 4% and 5% in most genotypes. The RA concentration declined again at 6% sucrose in all genotypes. We concluded that for the extraction of RA from rosemary callus it is preferred to be produced in the dark—this will save energy and will produce more RA than the light treatment. Also it is preferred to use sucrose concentration at 4% for genotypes Rosmarinus officinalis, Pine Scented, and APR; and 3% sucrose for genotype Madeline Hill in the dark condition. While for the light condition, it is preferred to use 5% sucrose with genotypes Majorca, Rosmarinus officinalis, Pine Scented, and Madeline Hill; and 4% sucrose for genotype APR.
9
Tawfeeq, Amani A., Monther F. Mahdi, Ibrahim S. Abaas, and Ali Hussein Alwan. "Phytochemical and anti bacterial studies of leaves of Rosmarinus officinalis cultivated in Karbala, Iraq." Al Mustansiriyah Journal of Pharmaceutical Sciences 17, no. 2 (March 10, 2018): 9. http://dx.doi.org/10.32947/ajps.v17i2.48.
Full textAbstract:
Rosmarinus officinalis is one of the important bioactive medicinal plants belongs to labiatae family. The aim is to identifying the essential oil and rosmarinic acid extracted from rosemary leaves and to evaluate its anti bacterial activity. Gas Chromatography-Mass analysis was performed for essential oil of rosemary and HPTLC analysis was done for 90% methanolic extract of rosemary leaves. Rosmarinic acid was detected and The essential oil content was 1.5% and characterized with high amount of 1,8 cineol (53.63%) . The zone of inhibition of some bacteria was estimated. Our findings showed that rosemary leaves has Good percentage of rosemary phytochemicals (essential oil and rosmarinic acid) and has significant antibacterial activity against different species of bacteria.
10
Gonçalves, Catarina, Daniela Fernandes, Inês Silva, and Vanessa Mateus. "Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation." Molecules 27, no. 3 (January 18, 2022): 609. http://dx.doi.org/10.3390/molecules27030609.
Full textAbstract:
This systematic review aimed to evaluate the potential anti-inflammatory effect of Rosmarinus officinalis in preclinical in vivo models of inflammation. A search was conducted in the databases PubMed, Scopus, and Web of Science, with related keywords. The inclusion criteria were inflammation, plant, and studies on rats or mice; while, the exclusion criteria were reviews, studies with in vitro models, and associated plants. The predominant animal models were paw edema, acute liver injury, and asthma. Rosemary was more commonly used in its entirety than in compounds, and the prevalent methods of extraction were maceration and hydrodistillation. The most common routes of administration reported were gavage, intraperitoneal, and oral, on a route-dependent dosage. Treatment took place daily, or was single-dose, on average for 21 days, and it more often started before the induction. The most evaluated biomarkers were tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, myeloperoxidase (MPO), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), malondialdehyde (MDA), and superoxide dismutase (SOD). The best results emerged at a dose of 60 mg/kg, via IP of carnosic acid, a dose of 400 mg/kg via gavage of Rosmarinus officinalis, and a dose of 10 mg/kg via IP of rosmarinic acid. Rosmarinus officinalis L. showed anti-inflammatory activity before and after induction of treatments.
Dissertations / Theses on the topic "Rosmarinus officinali"
1
Luis, Jorge J. C. "Analysis of the effects of abiotic stress conditions on Rosmarinus officinalis L. antioxidants : rosmarinic and carnosic acids." Thesis, University of Reading, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410552.
Full text
2
Machado, Daniele Guilhermano. "Investigação do potencial antidepressivo de Rosmarinus officinalis." Florianópolis, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/96131.
Full textAbstract:
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Made available in DSpace on 2012-10-26T09:06:40Z (GMT). No. of bitstreams: 0
Rosmarinus officinalis L. (Labiatae), alecrim, possui várias aplicações terapêuticas na medicina popular no tratamento de várias doenças, incluindo a depressão. Primeiramente, o efeito do extrato hidroalcoólico dos talos e folhas desta planta foi investigado em dois testes comportamentais preditivos de atividade antidepressiva, o teste do nado forçado (TNF) e teste de suspensão da cauda (TSC) em camundongos. Rosmarinus officinalis produziu um efeito tipo-antidepressivo, pois o tratamento agudo com o extrato desta planta por via oral reduziu significativamente o tempo de imobilidade no TNF e TSC, sem alterar a atividade locomotora no teste de campo aberto. Além disso, a administração repetida (14 dias) do extrato produziu um efeito antidepressivo no TSC. O pré-tratamento com p-clorofenilalanina (PCPA, inibidor da síntese de serotonina, 4 dias consecutivos), NAN-190 (antagonista de receptores 5-HT1A), cetanserina (antagonista de receptores 5-HT2A), 1-(m-clorofenil) biguanida (mCPBG, agonista de receptores 5-HT3), prazosina (antagonista de a1-adrenoceptores), SCH23390 (antagonista de receptores dopaminérgicos D1) ou sulpirida (antagonista de receptores dopaminérgicos D2), mas não ioimbina (antagonista de a2-adrenoceptores) reverteu a redução do tempo de imobilidade causada pelo extrato administrado agudamente no TSC. A combinação de MDL72222 (antagonista de receptores 5-HT3) com uma dose sub-ativa do extrato produziu um efeito anti-imobilidade no TSC. Estes resultados sugerem que a ação antidepressiva do extrato de Rosmarinus officinalis é mediada por uma interação com os sistemas monoaminérgicos. Subsequentemente, foi investigado o efeito antidepressivo de frações de Rosmarinus officinalis: fração acetato de etila 1 e 2 (AcOEt1 e 2), hexânica (HEX), etanólica (ET), e fração isenta de óleo essencial (IOE), bem como o óleo essencial e dos compostos isolados carnosol e ácido betulínico no TSC. Todas as frações analisadas, óleo essencial e compostos isolados produziram efeito antidepressivo: frações AcOEt1, AcOEt2, HEX, ET e IOE, o óleo essencial, e os compostos isolados carnosol e ácido betulínico. Nenhum efeito psicoestimulante foi mostrado no teste do campo aberto, indicando que os efeitos no TSC são específicos. Estes resultados sugerem que o ácido betulínico e o carnosol podem ser responsáveis, pelo menos em parte, pelo o efeito anti-imobilidade dos extratos de Rosmarinus officinalis e que o óleo essencial pode também contribuir para o efeito antidepressivo desta planta. Adicionalmente, o efeito do ácido ursólico no TSC e o envolvimento do sistema dopaminérgico neste efeito foram investigados. O ácido ursólico reduziu o tempo de imobilidade no TSC. O efeito do ácido ursólico no TSC foi prevenido pelo pré-tratamento de camundongos com SCH23390 (antagonista do receptores dopaminérgicos D1) e sulpirida (antagonista de receptores dopaminérgicos D2). A administração de doses sub-efetivas de ácido ursólico e de SKF38393 (agonista de receptores dopaminérgicos D1), apomorfina (agonista de receptores dopaminérgicos D2) ou bupropiona (inibidor da recaptação de dopamina) reduziu o tempo de imobilidade no TSC, em comparação com o efeito produzido por cada composto isoladamente. O ácido ursólico e os agentes dopaminérgicos, sozinhos ou em combinação, não causaram alterações significativas nas atividade locomotora e exploratória. Estes resultados sugerem que o efeito antidepressivo de ácido ursólico no TSC seja mediado por uma interação com o sistema dopaminérgico, através da ativação dos receptores dopaminérgicos D1 e D2. Em outra etapa experimental, as alterações induzidas pela bulbectomia olfatória (BO), modelo animal de depressão, e a influência do tratamento com fluoxetina (14 dias) sobre as alterações comportamentais induzidas por este modelo foram estudadas. O tratamento com fluoxetina reverteu a hiperatividade induzida pela BO no teste de campo aberto, a hiperatividade locomotora e o aumento do comportamento exploratório induzida pela novidade no teste de objeto novo e no teste da caixa nova e o comportamento anedônico no splash teste. A BO causou um aumento na atividade da acetilcolinesterase (AchE) no hipocampo, mas não no córtex cerebral, efeito que foi revertido pela fluoxetina. Corticosterona sérica foi aumentada em camundongos SHAM e bulbectomizados tratados com fluoxetina. Em conclusão, as alterações comportamentais e neuroquímicas induzidas pela BO foram revertidas pela fluoxetina, validando este modelo de depressão. Subsequentemente, foi investigada a habilidade do extrato de Rosmarinus officinalis em reverter alterações comportamentais e bioquímicas induzidas pela BO. A atividade locomotora e exploratória foi avaliada no teste de campo aberto, no teste do objeto novo e no teste da caixa nova, comportamento anedônico foi avaliado no splash teste, o déficit cognitivo foi avaliado no labirinto aquático de Morris. Para a etapa experimental 1, o extrato ou fluoxetina foram administrados por via oral (p.o.) uma vez ao dia durante 14 dias após a BO. Para a etapa experimental 2, foram determinados a glicemia e a atividade da AchE hipocampal e cerebrocortical em camundongos SHAM e bulbectomizados tratados com o extrato ou fluoxetina. O extrato, de forma semelhante à fluoxetina, reverteu a hiperatividade, o aumento do comportamento exploratório e o comportamento anedônico. Os animais bulbectomizados necessitaram maior número de treinos na sessão de treino para adquirir a informação espacial, porém estes exibiram um perfil semelhante ao dos camundongos SHAM na sessão de teste, demonstrando um déficit seletivo na aprendizagem espacial. Assim, a BO causou um déficit na aprendizagem, mas não na memória no teste do labirinto aquático de Morris, e este resultado não foi revertido pelo extrato ou fluoxetina. A redução dos níveis de glicose sérica e o aumento da atividade da AchE no hipocampo foram observados em camundongos bulbectomizados, mas apenas o último efeito foi revertido pela fluoxetina, enquanto ambos os efeitos foram revertidos pelo extrato de Rosmarinus officinalis. Em conclusão, o extrato desta planta, exerce um efeito antidepressivo em camundongos bulbectomizados e reverte a disfunção colinérgica e a hipoglicemia induzida pela BO. Em conjunto, os resultados sugerem o potencial de Rosmarinus officinalis para o tratamento de depressão e contribuem para a validação do uso tradicional desta planta para o tratamento desta doença.
Rosemary, Rosmarinus officinalis L. (Labiatae) has several therapeutic applications in folk medicine in managing a wide range of diseases, including depression. Firstly, in this study, the effect of the hydroalcoholic extract of the stems and leaves of this plant was investigated in two behavioral models predictive of antidepressant activity, the forced swimming test (FST) and tail suspension test (TST) in mice. Rosmarinus officinalis hydroalcoholic extract (ROHE) produced an antidepressant-like effect, since the acute treatment of mice with the extract by p.o. route significantly reduced the immobility time in the FST and TST, as compared to the control group, without accompanying changes in ambulation in the open-field test. Moreover, the repeated administration (14 days) of ROHE by p.o. route also produced an antidepressant-like effect in the TST. The pretreatment of mice with pchlorophenylalanine (PCPA, an inhibitor of serotonin synthesis, for 4 consecutive days), NAN-190 ( a 5-HT1A receptor antagonist), ketanserin (a 5-HT2A receptor antagonist), 1-(m-chlorophenyl) biguanide (mCPBG, a 5-HT3 receptor agonist), prazosin (an á1- adrenoceptor antagonist), SCH23390 (a dopamine D1 receptor antagonist) or sulpiride (a dopamine D2 receptor antagonist), but not yohimbine (an á2-adrenoceptor antagonist) reversed the anti-immobility effect ROHE in the TST. The combination of MDL72222, (a 5-HT3 receptor antagonist) with a sub-effective dose of ROHE produced an anti-immobility effect in the TST. These results suggest that the antidepressant action of ROHE is mediated by an interaction with the monoaminergic system. Subsequently, the antidepressant-like effects of fractions from Rosmarinus officinalis: ethyl acetate 1 and 2 (AcOEt1 and 2), hexane (HEX), ethanolic (ET), and essential oil free (EOF) fractions, as well essential oil and isolated compounds carnosol and betulinic acid were investigated. All of them produced a significant antidepressant-like effect in the TST: AcOEt1, AcOEt2, HEX, ET and EOF fractions, essential oil and isolated compounds carnosol and betulinic acid. No psychostimulant effect was shown in the open-field test, indicating that the effects in the TST are specific. This study suggests that carnosol and betulinic acid could be responsible, at least in part, for the anti immobility effect of extracts from Rosmarinus officinalis. The essential oil of this plant can also contribute to this effect. Additionally, the antidepressant-like effect of ursolic acid was investigated, well as the involvement of dopaminergic system in its effect. Ursolic acid reduced the immobility time in the TST. The effect of ursolic acid in TST was prevented by the pretreatment of mice with SCH23390 (a dopamine D1 receptor antagonist) and sulpiride (a dopamine D2 receptor antagonist). The administration of a sub-effective dose of ursolic acid in combination with sub-effective doses of SKF38393 (a dopamine D1 receptor agonist), apomorphine (a dopamine D2 receptor agonist) or bupropion (a dopamine reuptake inhibitor) reduced the immobility time in the TST as compared with either drug alone. Ursolic acid and dopaminergic agents alone or in combination did not cause significant alterations in the locomotor and exploratory activities. These results indicate that the antidepressant-like effect of ursolic acid in the TST is likely mediated by an interaction with the dopaminergic system, through the activation of dopamine D1 and D2 receptors. In another experimental approach the effects of chronic treatment with fluoxetine (14 days) on the behavioral alterations induced by olfactory bulbectomy (OB) were investigated. Fluoxetine reversed OB-induced hyperactivity in the open-field, novel object and novel cage tests, and anhedonic behavior in the splash test. OB caused an increase in hippocampal, but not cerebrocortical AChE activity, an effect reversed by fluoxetine. Serum corticosterone was increased in SHAM and bulbectomized mice treated with fluoxetine. In conclusion, OB-induced behavioral and neurochemical alterations were reversed by fluoxetine, validating this model of depression. In addition, the ability of ROHE, as compared with fluoxetine to reverse behavioral and biochemical alterations induced by OB was investigated. Locomotor and exploratory behavior was assessed in the open-field test, in the novel object test and in the novel cage test, anhedonic behavior was assessed in the splash test, cognitive deficits were evaluated in the water maze. For the first set of experiments, ROHE or fluoxetine was administered once daily for 14 days 2 weeks after OB. For experiment 2, serum glucose and hippocampal and cerebrocortical AChE activity were determined in OB and SHAM-operated mice treated orally with ROHE or fluoxetine. The results show that ROHE, similarly to fluoxetine, reversed OB-induced hyperactivity, and increased exploratory and anhedonic behaviors. OB mice needed significantly more trials in the training session to acquire the spatial information, but they displayed a similar profile to that of SHAM mice in the test session, demonstrating a selective deficit in spatial learning, which was not reversed by extract or fluoxetine. A reduced serum glucose levels and an increased hippocampal AChE activity were observed in bulbectomized mice, only the latter effect was reversed by fluoxetine, while both effects were reversed by ROHE. In conclusion, ROHE exerts an antidepressant-like effect in bulbectomized mice and is able to reverse OB-induced cholinergic dysfunction and hipoglicemia. Overall, results suggest the potential of Rosmarinus officinalis for the treatment of depression and contribute towards validation of the traditional use of this plant for the treatment of this disease.
3
VALONES, Marcela Agne Alves. "Avaliação da atividade antimicrobiana in vitro do dentifrício à base do extrato alcoólico de Rosmarinus Officinalis Linn. (ALECRIM) sobre cepas padrão de S. mutans, S. aureus e L. casei." Universidade Federal de Pernambuco, 2008. https://repositorio.ufpe.br/handle/123456789/8053.
Full textAbstract:
Made available in DSpace on 2014-06-12T22:56:47Z (GMT). No. of bitstreams: 2
arquivo3991_1.pdf: 493152 bytes, checksum: 5d39ee84844d6c047797977dda4369f8 (MD5)
license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5)
Previous issue date: 2008O objetivo deste trabalho foi avaliar a atividade antimicrobiana do extrato alcoólico de Rosmarinus officinallis Linn. (Alecrim) sobre bactérias da cavidade oral, causadoras de patologias desta região. Para o estudo, utilizaram-se cepas padrão de Streptococcus mutans (ATCC 25175), Lactobacillus casei (ATCC 7469) e Staphylococcus aureus (ATCC 9811), tendo como controle positivo a clorhexidina 0,12%. Folhas de alecrim foram tratadas com etanol, obtendo-se um extrato, e esse, rotaevaporado até a secura e diluído até 1:8 para a realização do Teste de Difusão em Ágar. Neste teste, placas de Petri foram semeadas com as bactérias e discos de papel embebidos com o extrato e suas diluições colocados sobre as placas. Em seguida, tais placas foram incubadas de acordo com as exigências de crescimento das bactérias, sendo os halos de inibição analisados. Observaram-se halos para S. mutans e S. aureus similares ao controle positivo clorhexidina, enquanto a CIM foi 30μg/ml para S. aureus e 50μg/ml para S. mutans e L. casei, resultados esses melhores do que os da literatura para o extrato de Rosmarinus officinalis Linn. Assim, o extrato alcoólico de alecrim apresenta atividade antimicrobiana sobre bactérias da cavidade bucal e pode ser empregado como apoio à prevenção e terapia das doenças cárie e periodontal
4
Diemer, Andréa Wolf. "Ação antimicrobiana de Rosmarinus officinalis e Zingiber officinale frente a Escherichia coli e Staphylococcus aureus em carne mecanicamente separada de frango." reponame:Repositório Institucional da UNIVATES, 2016. http://hdl.handle.net/10737/1075.
Full textAbstract:
Submitted by FERNANDA DA SILVA VON PORSTER (fdsvporster@univates.br) on 2016-07-28T19:15:39Z
No. of bitstreams: 2
license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)
2016AndreaWolfDiemer.pdf: 7026928 bytes, checksum: 2b39a82b98f08b5661a740f008264243 (MD5)Approved for entry into archive by Ana Paula Lisboa Monteiro (monteiro@univates.br) on 2016-08-30T12:00:31Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) 2016AndreaWolfDiemer.pdf: 7026928 bytes, checksum: 2b39a82b98f08b5661a740f008264243 (MD5)
Made available in DSpace on 2016-08-30T12:00:31Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) 2016AndreaWolfDiemer.pdf: 7026928 bytes, checksum: 2b39a82b98f08b5661a740f008264243 (MD5) Previous issue date: 2016-07
A indústria de produtos cárneos, necessita produtos que possuem uma demanda alta de vendas, porém, o consumidor, em busca de uma vida mais saudável está exigindo produtos com praticidade, qualidade, segurança e que estes sejam nutritivos. Um dos ingredientes utilizados para a fabricação de produtos a base de carne é o nitrito. Este melhora a coloração, realça o sabor, impede a oxidação lipídica e é um importante agente bactericida na indústria de alimentos. Porém, o nitrito, em concentrações elevadas pode ser carcinogênico. Levando isto em consideração o objetivo deste trabalho é avaliar a ação antimicrobiana de extrato aquoso e óleo essencial de alecrim (Rosmarinus officinalis) e gengibre (Zingiber officinale) frente a Escherichia coli e Staphylococcus aureus em carne mecanicamente separada de frango (CMS).Realizou-se as análise da CIM e CBM sendo que para E. coli utilizando o extrato aquoso de alecrim verificou-se, uma CIM de 5,0 mg/mL e CBM >20 mg/mL, enquanto o extrato aquoso de gengibre uma CIM de 20 mg/mL e CBM >20 mg/mL. Para o óleo essencial de alecrim constatou-se uma CIM de 1,25 mg/mL e CBM de 2,5 mg/mL, enquanto o óleo de gengibre uma CIM de 1,25 mg/mL e CBM de 5,0 mg/mL. Para S. aureus utilizando o extrato aquoso de alecrim, obteve-se uma CIM e CBM de 5,0 mg/mL, enquanto o extrato aquoso de gengibre uma CIM e CBM de 20 mg/mL. Para o óleo essencial de alecrim constatou- se uma CIM de 0,625 mg/mL e CBM de 1,25 mg/mL, enquanto o óleo de gengibre uma CIM de 1,25 mg/mL e CBM de 2,5 mg/mL. A partir destes resultados pode-se dizer que os mesmos demonstram-se promissores em relação a ação bactericida e bacteriostática. Em posse dos resultados da CIM e CBM, descartou-se o uso dos extratos aquosos, em função da baixa atividade detectada na CIM e CBM, então seguiu-se os experimentos somente com os óleos essenciais, em seguida, realizou- se as análises de contagem de colônias (UFC) das amostras. Para estas análises verificou-se que o óleo de alecrim e gengibre frente as bactérias Escherichia coli (ATCC 25922) e Staphylococcus aureus (ATCC 6538P), não apresentaram efeito bacteriostático e nem bactericida. Diante de todos os resultados constatou-se que a CIM e CBM não podem ser utilizados como parâmetro microbiológico para matrizes cárneas, pois o comportamento bactericida e bacteriostáticos não se equivaleram, isso para as condições dos experimentos realizados nesta pesquisa.
The industry of meat products, you need products that have a high demand for sales, however, consumers in search of a healthier life is demanding products with convenience, quality, safety and they are nutritious. One of the ingredients used for the manufacture of meat products is nitrite. This improves the color, enhance flavor, prevent lipid oxidation and is an important bactericidal agent in the food industry. However, the nitrite in high concentrations may be carcinogenic. Taking this into account the objective of this study is to evaluate the antimicrobial activity of aqueous extract and essential oil of rosemary (Rosmarinus officinalis) and ginger (Zingiber officinale) against Escherichia coli and Staphylococcus aureus in mechanically deboned chicken meat (CMS). It was performed the analysis of MIC and MBC where in E. coli using the aqueous extract of rosemary was found a MIC of 5.0 mg/mL and MBC> 20 mg/mL, while the aqueous extract of ginger a 20 MIC mg/mL and MBC> 20 mg/mL. For rosemary essential oil found to be a MIC of 1.25 mg/mL and MBC of 2.5 mg/mL, where as the MIC one ginger oil 1.25 mg/mL and CBM 5.0 mg/mL. For S. aureus using the aqueous extract of rosemary, obtained an MIC and MBC of 5.0 mg/mL while the aqueous extract of ginger one MIC and MBC 20 mg/mL. For rosemary essential oil found to be a MIC of 0.625 mg/mL and MBC of 1.25 mg/mL, where as the MIC one ginger oil 1.25 mg/mL and MBC of 2.5 mg/mL. From these results it can be said that they show promise in relation to bactericidal and bacteriostatic action. In possession of the results of MIC and MBC, was discarded the use of aqueous extracts, due to the low activity detected in MIC and MBC, then the experiments followed only with essential oils, then was held the analyzes of colony counts (CFU) of the samples. For this analysis it was found that rosemary oil and ginger front bacteria Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 6538P), and showed no bacteriostatic or bactericidal effect. Before all the results it was found that the MIC and MBC can not be used as microbiological parameter to cárneas arrays, because the bactericidal and bacteriostatic behavior is not equaled, that for the conditions of the experiments in this study.
5
Westervelt, Paul Matthew. "Challenges in the Greenhouse Production of Rosmarinus officinalis L." Thesis, Virginia Tech, 2003. http://hdl.handle.net/10919/34696.
Full textAbstract:
Rosmarinus officinalis L. (rosemary) is popular as a culinary herb, landscape plant, and potted florist's crop. Little research has been reported on the greenhouse production of this plant. Effects of irrigation rate, fertilizer concentration, and growing media on root and shoot growth were investigated for R. officinalis 'Athens Blue Spires'. In the first experiment, rooted cuttings were potted and received fertilizer treatments of 100, 200, or 300 mg?L-1 nitrogen (N) from 15N-2.2P-12.2K water-soluble fertilizer for twelve weeks. Two irrigation regimes were imposed - plants were irrigated with fertilizer solution when the growing media dried down to less than 30% or 20% volumetric soil moisture content. Root and shoot dry weights showed irrigation rate did not effect roots, but the higher irrigation rate produced larger shoots at all fertilizer concentrations. The largest roots and shoots were a product of the lowest fertilizer concentration. In the second experiment, rooted cuttings of the same cultivar were potted and received fertilizer treatments of 50, 100, 150, or 200 mg?L-1 N from 15N-2.2P-12.2K water-soluble fertilizer for 2, 4, 6, or 8 weeks. Plants were harvested at the end of each treatment. A third irrigation regime was imposed - plants were irrigated with fertilizer solution when the growing media dried down to less than 40%, 30%, or 20% volumetric soil moisture content. Root and shoot dry weights showed neither irrigation nor fertilizer were significant at week two, six, or eight. Dry weights showed irrigation was significant for roots at week four with the lowest irrigation rate producing the largest roots at all fertilizer concentrations except 100 mg?L-1 at the less than 30% irrigation rate. Irrigation was also significant at week four for shoots with the lowest irrigation rate producing the largest shoots at all fertilizer concentrations except 100 mg?L-1 at the less than 30% irrigation rate. In the third experiment 'Athens Blue Spires' rooted cuttings were potted in five different soilless media [Fafard 52 (24% peat, 60% bark, 8% perlite, 8% vermiculite); Fafard 3B (45% peat, 25% bark, 15% perlite, 15% vermiculite); Scott's Sierra Perennial Mix (25% peat, 65% bark, 10% perlite); Scott's Metro Mix 700 with Coir (25% coir, 50% bark, 10% perlite, 15% vermiculite); and a nursery mix (89% pine bark, 11% sand)]. Plants were irrigated for fourteen weeks with 150 mg?L-1N fertilizer solution when the growing media dried down to less than 30% or <20% volumetric soil moisture content. Growing media affected shoot dry weight with the highest-percentage peat media (Fafard 3B) producing the largest plants. All were of marketable quality. Irrigation rate did not affect root dry weight, but the higher rate produced larger shoots in each of the five media. The fourth experiment examined the growth of R. officinalis 'Tuscan Blue' rooted cuttings when planted in five different growing media [Fafard 52, Fafard 3B, Scott's Perennial, Metro Mix 560 with coir (30% coir, 15% peat, 40% bark, and 15% perlite), and 100% pine bark]. A third irrigation regime was imposed - plants were irrigated with 150 mg?L-1N fertilizer solution when the growing media dried down to less than 40%, 30%, or 20% volumetric soil moisture content. Treatments lasted for 2, 4, 6, or 8 weeks and plants were harvested at the end of each treatment. Dry weights showed neither media nor irrigation was significant for roots or shoots at weeks four or eight. However, at week two, media significantly affected root dry weight with the heaviest roots produced by the two perennial mixes (Scott's perennial and Fafard 52). Growing media affected shoot dry weight at week six with the highest-percentage peat media (Fafard 3B) producing the largest plants at the low and high irrigation rate. Irrigation also affected root dry weight at week six with the two lowest irrigation rates producing the heaviest roots in all media.Master of Science
6
Villar, Bustamante Carmen Luz. "Actividad antioxidante de los extractos secos de Melissa officinalis (melisa) y Rosmarinus officinalis (romero)." Tesis, Universidad de Chile, 2012. http://www.repositorio.uchile.cl/handle/2250/116716.
Full textAbstract:
Memoria para optar al título de Químico FarmacéuticoLos polifenoles herbales están representados por un grupo de compuestos que incluyen moléculas lipofílicas y polares. Plantas medicinales utilizadas para mitigar patologías psicotrópicas deben contener principios activos lipofílicos que sean capaces de atravesar la barrera hemato-encefálica. Diversos estudios demuestran la asociación de la enfermedad de Alzheimer´s y la de Parkinson´s a estrés oxidativo, fenómeno que parece estar relacionado con concentraciones elevadas de hierro y cobre que se han descrito en neuronas de estos pacientes. De aquí nuestro interés en evaluar la capacidad antioxidante de extractos secos estandarizados de hojas de Melissa officinalis (melisa) y Rosmarinus officinalis (romero), plantas utilizadas para mitigar efectos psicotrópicos como ansiedad y depresión. Para ello, se utilizó como sistema biológico una preparación enriquecida en retículo endoplásmico hepático de rata (microsomas) y como sistema oxidante, Cu2+/ascorbato. Ambos extractos previnieron la lipoperoxidación microsómica inducida por Cu2+/ascorbato. Además, ellos fueron capaces de prevenir la disminución de los tioles proteicos inducida por Cu2+ ya sea en presencia como en ausencia de ascorbato. Esto indica que los principios activos presentes en estos extractos podrían ejercer su acción antioxidante al menos a través de dos mecanismos: a) atrapamiento de radicales libres del oxígeno y b) quelación de iones metálicos que generan ROS a través de las reacciones de Haber-Weiss y/o Fenton. Más aún, ambos extractos fueron capaces de inhibir la actividad N-desmetilante de aminopirina del sistema CYP450, el cual metaboliza sustratos lipofílicos. Cabe resaltar que los efectos de romero fueron significativamente superiores a los de melisa. Estos resultados aunque preliminares, son promisorios y nuevos experimentos están en curso conducentes a evaluar en modelos animales la eficacia y seguridad de estos extractos
Herbal polyphenols are represented by a group of compound that includes lipophilic and polar compounds. Medicinal plants used to mitigate psychotropic pathologies must contain active lipophilic principles capable of crossing the blood-brain barrier. Studies have shown the association of Parkinson's and Alzheimer's diseases to oxidative stress, phenomenon that seem to be related with elevated concentrations of iron and copper In the neurons of these patients. Hence our interest in evaluating the antioxidant capacity of standardized dry extracts of Melissa officinalis (lemon balm) and Rosmarinus officinalis (rosemary) leaves, plants used to mitigate psychotropic effects such as anxiety and depression. An enriched preparation of rat liver endoplasmic reticulum (microsomes) was used as a biological system in and Cu2+/ascorbate, as oxidant system. Both extracts prevented microsomal lipid peroxidation induced by Cu2+/ascorbate. Furthermore, they were able to prevent the decrease of protein thiols induced by Cu2+ either in the presence or absence of ascorbate. This indicates that the principles antioxidants in rosemary and lemon balm extract may exert its cellular antioxidant activity through at least two mechanisms: a) trapping of oxygen free radicals and b) chelation of metals ions, which generate ROS through Haber-Weiss and/or Fenton reactions. Moreover, both extracts were able to inhibit the aminopyrine N-demethylating activity of CYP450 system, which metabolizes lipophilic compounds. It necessary to point out that the effects of rosemary were significantly higher than balm. These results, though preliminary, are promising and further experiments are underway leading in animal models to evaluate the efficacy and safety of these extracts
7
de, Souza Araújo Silva Manoela. "Atividade antimicrobiana in vitro do extrato hidroalcoólico de alecrim (Rosmarinus officinalis Linn.) sobre bactérias orais planctônicas." Universidade Federal de Pernambuco, 2005. https://repositorio.ufpe.br/handle/123456789/8615.
Full textAbstract:
Made available in DSpace on 2014-06-12T23:01:30Z (GMT). No. of bitstreams: 2
arquivo8544_1.pdf: 706882 bytes, checksum: 7f552d13edf81608cb94ae198a8dccde (MD5)
license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5)
Previous issue date: 2005Neste estudo foi investigada a capacidade antimicrobiana in vitro do extrato hidroalcoólico de alecrim (Rosmarinus officinalis Linn.) sobre bactérias orais planctônicas. Foram utilizados o extrato puro, suas diluições de 1/2 à 1/512, clorexidina e cepas padrão de Streptococcus mitis ATCC 98811, Streptococcus sanguinis ATCC 10556, Streptococcus mutans ATCC 25175, Streptococcus sobrinus ATCC 27609 e Lactobacillus casei ATCC 7469. Inicialmente, foi determinada a CIM do extrato de alecrim pelo método de difusão em meio sólido sobre as cepas supracitadas. Em seguida, foi determinada a CIMA do extrato sobre as cepas padrão de Streptococcus mitis ATCC 98811, Streptococcus sanguinis ATCC 10556, Streptococcus mutans ATCC 25175, Streptococcus sobrinus ATCC 27609, na presença de sacarose a 5%. Todos os ensaios foram realizados em duplicata e a clorexidina foi utilizada como solução controle. A CIM variou de 66,5 mg/mL a 266 mg/mL e a CIMA de 16 mg/mL a 33,2 mg/mL. Foi observado que o extrato hidroalcoólico puro de alecrim e diluído até 1/16 apresentou ação antimicrobiana sobre as cepas padrão ensaiadas, exceto sobre Streptococcus mitis ATCC 98811. Não foi observado efeito inibitório de aderência sobre Streptococcus sanguinis ATCC 10556. Streptococcus mutans ATCC 25175 e Lactobacillus casei ATCC 7469 foram as cepas mais sensíveis à ação antimicrobiana in vitro do extrato de alecrim
8
Tawfeeq, Anas. "Factors affecting essential oil production in rosemary (Rosmarinus officinalis L.)." Thesis, University of Reading, 2017. http://centaur.reading.ac.uk/78261/.
Full textAbstract:
There are many factors shown to have beneficial effects on many crop plants. Here we investigate the impact of fertilizers and genetic variation on Rosmarinus officinalis L. measured by both oil yield and quality. Plants grown in a temperature-controlled greenhouse with a natural photoperiod and a controlled irrigation system were treated with seaweed fertilizer and an inorganic fertilizer of matching mineral composition but with no organic content. Treatments were either by spraying on to the foliage or watering direct to the compost. The essential oil was extracted by hydro-distillation with a Clevenger apparatus and analysed by gaschromatography mass-spectrometry (GC–MS) and nuclear magnetic resonance spectroscopy (NMR). The crop responded positively to the application of fertilizer when compared to the control (no fertilizer). The seaweed treatments caused a significant increase in oil amount and leaf area as compared with both inorganic treatments and the control regardless of application method. The application of cytokinin in seaweed form also had a positive role with plant growth and oil production. The chemical compositions of the plants were compared, and qualitative differences were found between fertilizer treatments, application methods, ages of the plant and different genotype. The difference in oil composition were influenced partly by applying seaweed fertilizer. A full chemical analysis of the essential oil was conducted in order to identify the main components. Nine compounds were determined. Eucalyptol and camphene were shown to make up more than half. The other compounds made up the remaining 30%. In general, oil yields are reduced in the older plants whether from those with applied fertilizer or the control. The different genotypes showed a highly significant difference in oil composition and yield compared with other factors affecting essential oil production showing that rosemary plants vary greatly and the correct cultivar should be chosen with reference to its intended final use.
9
Dalmarco, Juliana Bastos. "Estudo das propriedades químicas e biológcas de Rosmarinus officinalis L." reponame:Repositório Institucional da UFSC, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/100930.
Full textAbstract:
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2012.Made available in DSpace on 2013-06-26T00:00:15Z (GMT). No. of bitstreams: 1 314574.pdf: 1881354 bytes, checksum: 5680ddc3fdc095167ab77d781315e64e (MD5)
Introducao: Rosmarinus officinalis L. (Lamiaceae) e uma planta medicinal e aromatica e esta distribuida em diversas regioes do mundo. E apontada por possuir alta capacidade antioxidante, sendo muito utilizada na medicina tradicional e tambem na alimentacao. Objetivos: o objetivo deste trabalho foi investigar fitoquimicamente a especie R. officinalis e avaliar os efeitos antibacteriano, anti-inflamatorio e antidepressivo. Metodologia: partes aereas da planta foram secas e maceradas em etanol 96% durante dez dias, produzindo o extrato bruto. O extrato bruto foi particionado atraves de filtracao em silica utilizando solventes de polaridade crescente resultando nas fracoes hexano, acetato de etila, etanolica e aquosa. As fracoes hexano e acetato de etila foram submetidas a procedimentos cromatograficos para o isolamento dos compostos. Os compostos foram quantificados no extrato bruto e fracoes utilizando as tecnicas de CLAE-UV e EC. O efeito anti-inflamatorio de R. officinalis foi analisado no modelo da pleurisia induzida pela carragenina em camundongos. O efeito antibacteriano foi avaliado pelo metodo de microdiluicao em caldo. Finalmente, o estudo antidepressivo foi analisado frente aos modelos do nado forcado e da suspensao em cauda. Resultados: a analise do oleo essencial apresentou como majoritario o composto 1,8 cineol. Pela analise fitoquimica, foi possivel elucidar quatro compostos: tres terpenos, acido betulinico, acido ursolico, oleanolato metilico e um diterpeno fenolico, o carnosol. Alem disso, verificou-se que diferentes solventes interferem na degradacao do extrato bruto. Em relacao a atividade anti-inflamatoria, podemos destacar que em relacao a inibicao na migracao leucocitaria, a fracao etanolica e o composto isolado acido ursolico apresentaram melhores resultados, obtendo o mesmo perfil frente a migracao de neutrofilos e a exsudacao. A inibicao da enzima MPO, foi mais evidente quando os animais foram tratados com o extrato bruto e com o terpeno, acido betulinico. Ja a producao de metabolitos do oxido nitrico (NOx), a fracao mais efetiva foi novamente a fracao etanolica, e o composto mais efetivo foi o carnosol. Finalmente, a inibicao da liberacao das citocinas pro-inflamatorias IL-1B e TNF-a, foi fortemente inibida pelo extrato bruto e pelo terpeno acido betulinico. No estudo antibacteriano de R. officinalis, o composto isolado acido ursolico exibiu otima atividade antibacteriana frente ao Streptococcus pyogenes e boa atividade contra Staphilococcus aureus Resistente a Meticilina (MRSA). Ja o acido betulínico foi considerado inativo contra as bactérias testadas. O carnosol demonstrou bom efeito antibacteriano contra Streptococcus faecalis, Shigella flexinerii, Salmonella typhi e Staphylococcus aures Resistente a Meticilina (MRSA). O estudo antidepressivo do extrato bruto, compostos isolados e óleo essencial da Rosmarinus officinalis, demonstrou resultados importantes. Muitos deles comparados aos resultados apresentados pela fluoxetina, com destaque para o extrato bruto, ácido ursólico e óleo essencial, o que sugere a possibilidade de utilização da planta no tratamento da depressão. Conclusão: de acordo com os resultados obtidos, foi possível verificar que o alecrim possui importante propriedade anti-inflamatória, antibacteriana e principalmente antidepressiva. Estes efeitos podem ser atribuídos a presença dos compostos isolados como o carnosol e principalmente o ácido ursólico o qual demonstrou os melhores efeitos farmacológicos.
Abstract : Introduction: the Rosmarinus officinalis L. (Lamiaceae) is an aromatic and medicinal plant and is distributed in various regions of the world and is identified as having high antioxidant capacity, and is widely used in traditional medicine as well as food. Objectives: the objective of this study was investigate the phytochemistry of R. officinalis and evaluate possible biological activities of this plant through tests to assess anti-inflammatory, antibacterial and antidepressant activities. Metodology: the methodology as follows: the aerial parts of the plant were dried and soaked in 96% ethanol for ten days, yielding the crude extract. The crude extract was partitioned by filtration on silica using increasingly polar solvents resulting in hexane, ethyl acetate, ethanol and aquous fractions. The fractions hexane and ethyl acetate were subjected to chromatographic procedures for isolation of compounds. The quantification of compounds in the crude extract and fractions were made by HPLC-UV and CE.The anti-inflammatory effect of R. officinalis was analyzed in the model of carrageenan-induced pleurisy in mice. The antibacterial effect was assessed using the microdilution method. Finally, the study of the antidepressant effect was assesed by the models of forced swim and tail suspension. Results: the essential oil presented as majority compound 1,8 cineol. Through phytochemical analysis, it was possible to elucidate four compounds: three terpenes, betulinic acid, ursolic acid, methyl oleanolato and a diterpene phenol carnosol. Furthermore, it was found that different solvents interfere with the degradation of crude extract fractions. The results of anti-inflammatory activity, we highlight that for inhibition of leukocyte migration, and the ethanol fraction isolated compound ursolic acid showed better results, achieving the same profile front neutrophil migration and exudation. The inhibition of the enzyme MPO was more evident when the animals were treated with the crude extract and the terpene betulinic acid. The production of nitric oxide metabolites (NOx), the most effective fraction was again the ethanol fraction, and the compound most effective was the carnosol. In the study of antibacterial activity of R. officinalis, the isolated compound ursolic acid exhibited excellent antibacterial activity against the Streptococcus pyogenes and good activity against Methicillin Resistant Staphylococcus aureus (MRSA). Already betulinic acid was found inactive against all bacteria tested. The carnosol demonstrated good antibacterial effect against Streptococcus faecalis, Shigella flexinerii, Salmonella typhi and MRSA. Finally, inhibition of the release of proinflammatory cytokines IL-1B and TNF-á, was strongly inhibited by the crude extract and betulinic acid. Finnaly, the study of antidepressant action of crude extract, isolated compounds and essential oil from Rosmarinus officinalis, showed startling results. Many of them, similar to presented by fluoxetine, highlights to crude extract, ursolic acid and essential oil which suggests the possibility of using the plant to treat depression. Conclusions: according to the results was possible to verify that the R. officinalis has an important anti-inflammatory, antibacterial and principally antidepressant properties. These effects may be attributable to isolated compounds such as carnosol and especially to ursolic acid which showed the best pharmacological effects.
10
Genena, Aziza Kamal. "Extração e caracterização do extrato de alecrim (Rosmarinus officinalis L.)." Florianópolis, SC, 2005. http://repositorio.ufsc.br/handle/123456789/101836.
Full textAbstract:
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnologico. Programa de Pós-graduação em Engenharia de AlimentosMade available in DSpace on 2013-07-15T23:20:17Z (GMT). No. of bitstreams: 1 212781.pdf: 3153473 bytes, checksum: 74c9dae2ec573489ff2fc08edfc5b2bc (MD5)
A oxidação de lipídios insaturados iniciada por radicais livres é uma das principais causas da deterioração da qualidade de alimentos, e, para retardá-la ou preveni-la, antioxidantes, que podem ser de origem sintética ou natural, são adicionados aos alimentos. Devido aos seus possíveis efeitos indesejáveis na saúde humana, o uso de antioxidantes sintéticos é restrito em vários países. Portanto, há um grande interesse na obtenção e utilização de antioxidantes naturais. O maior nível de atenção entre ervas e especiarias como fonte de antioxidantes tem sido focado no alecrim. A extração com fluido supercrítico é uma tecnologia de interesse para a indústria de alimentos, cosméticos e farmacêutica, como uma alternativa aos processos convencionais, para obtenção de óleos essenciais e oleoresinas, pois produz extratos livres de resíduos, e, pode ser conduzida a baixas temperaturas, preservando a qualidade de produtos termosensíveis. O presente trabalho teve como objetivo principal a obtenção e caracterização do extrato de alecrim visando a obtenção de compostos antioxidantes. No processo de obtenção do extrato avaliou-se a solubilidade preliminar do soluto no dióxido de carbono supercrítico, o ponto de inversão das isotermas, o efeito de algumas variáveis de processo (temperatura, tempo estático, pressão, vazão de solvente e granulometria) sobre o rendimento da extração supercrítica, e a aplicação de modelos para a predição das curvas de extração. Comparou-se os rendimentos, a atividade antioxidante, e a composição química dos extratos obtidos por diferentes métodos de extração. O modelo de Martínez et al. (2003) foi o que representou melhor os dados experimentais obtidos. O maior rendimento de extração foi obtido por extração Soxhlet com etanol. O principal composto obtido, através de análise CG-MS, em todos os extratos analisados, foi o isocarnosol, importante fenólico diterpênico e principal responsável pela atividade antioxidante do alecrim, justificando assim, a alta atividade antioxidante obtida nos extratos.
Books on the topic "Rosmarinus officinali"
1
Mehtap Ozcelik, Ulku Gulcihan Simsek, Songul Ceribasi, and M. Ciftci. Effects of different doses of rosemary oil (Rosmarinus officinalis L.) on oxidative stress and apoptosis of liver of heat stressed quails. Verlag Eugen Ulmer, 2014. http://dx.doi.org/10.1399/eps.2014.32.
Full textBook chapters on the topic "Rosmarinus officinali"
1
Azimova, Shakhnoza S., and Anna I. Glushenkova. "Rosmarinus officinalis." In Lipids, Lipophilic Components and Essential Oils from Plant Sources, 472. London: Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_1483.
Full text
2
Bährle-Rapp, Marina. "Rosmarinus officinalis." In Springer Lexikon Kosmetik und Körperpflege, 481. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_8990.
Full text
3
Sastry, K. Subramanya, Bikash Mandal, John Hammond, S. W. Scott, and R. W. Briddon. "Rosmarinus officinalis (Rosemary)." In Encyclopedia of Plant Viruses and Viroids, 2107. New Delhi: Springer India, 2019. http://dx.doi.org/10.1007/978-81-322-3912-3_798.
Full text
4
Anastassakis, Konstantinos. "Rosemary (Rosmarinus Officinalis)." In Androgenetic Alopecia From A to Z, 495–99. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08057-9_59.
Full text
5
Mersin, Burçin, and Gülçin Saltan İşcan. "Rosmarinus officinalis L." In Novel Drug Targets With Traditional Herbal Medicines, 525–41. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-07753-1_34.
Full text
6
Khare, C. P. "Rosmarinus officinalis Linn." In Indian Medicinal Plants, 1. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_1370.
Full text
7
Goetz, Paul, and Kamel Ghedira. "Rosmarinus officinalis (Lamiaceae): Romarin." In Collection Phytothérapie Pratique, 341–47. Paris: Springer Paris, 2012. http://dx.doi.org/10.1007/978-2-8178-0058-5_25.
Full text
8
Hammer, Merita, and Wolfram Junghanns. "Rosmarinus officinalis L.: Rosemary." In Handbook of Plant Breeding, 501–21. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-38792-1_15.
Full text
9
Paniagua-Zambrana, Narel Y., Rainer W. Bussmann, and Carolina Romero. "Salvia officinalis L. Salvia rosmarinus Scheid. Lamiaceae." In Ethnobotany of Mountain Regions, 1–10. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-77093-2_308-1.
Full text
10
Paniagua-Zambrana, Narel Y., Rainer W. Bussmann, and Carolina Romero. "Salvia officinalis L. Salvia rosmarinus Scheid. Lamiaceae." In Ethnobotany of Mountain Regions, 1621–30. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-28933-1_308.
Full textConference papers on the topic "Rosmarinus officinali"
1
Melo, Tayonara dos Santos, Abigail Eduarda de Miranda Magalhães, Auygna Pamyda Gomes da Silva, Eniete Lívia da Silva, Hévellin Talita Sousa Lins, Maria Amélia Paiva Ferruccio, Maria da Paz Rodrigues Silva, and Tuanne dos Santos Melo. "ATIVIDADE ANTIMICROBIANA DO ÓLEO ESSENCIAL DE Rosmarinus officinalis L. FRENTE À Escherichia coli: UMA REVISÃO INTEGRATIVA." In XXVII Semana de Biomedicina Inovação e Ciência. Editora IME, 2021. http://dx.doi.org/10.51161/9786588884119/35.
Full textAbstract:
Introdução: Os óleos essenciais (OE) são produtos naturais constituídos por compostos voláteis e aromáticos extraídos de diferentes partes de plantas que podem apresentar atividade antimicrobiana contra patógenos (1). A Rosmarinus officinalis L. (alecrim) é uma planta medicinal nativa da região mediterrânea e comumente utilizada como condimento e conservante de alimentos. Além disso, possui atividade antiinflamatória, antioxidante, antimicrobiana, antiproliferativa, antitumoral e protetora(2). A Escherichia coli é um patógeno bacteriano gram-negativo. Na última década várias cepas multirresistentes de E. coli evoluíram devido ao crescente uso de antimicrobianos, tornando-se um desafio clínico e epidemiológico (3). Em virtude disso, os pesquisadores têm investigado abordagens alternativas para seu tratamento. Objetivos: Produzir uma revisão bibliográfica sobre a atividade antimicrobiana do óleo essencial de Rosmarinus officinalis frente à Escherichia coli. Métodos: Trata-se de uma revisão de literatura integrativa. Utilizaram-se artigos obtidos nas bases de dados: BVS, PubMed e SciELO. Os descritores consultados foram “Rosmarinus officinalis”, “Oils, Volatile” e “Escherichia coli”. Os artigos selecionados foram publicados em inglês no período de 2016 a 2021. Resultados: Foram obtidos 22 artigos inicialmente e ao final foram selecionados 5 artigos que atenderam aos objetivos do estudo. Observou-se pelo método de difusão em disco que o OE de R. officinalis apresentou ação inibitória forte e leve, em 14% e 42% respectivamente, nos isolados de E. coli testados. Além disso, o OE de R. officinalis demonstrou efeito antibiofilme em 86,36% dos isolados testados. Dentre eles, 77,27% tornaram-se biofilme negativos além da cepa de referência. A porcentagem de inibição variou de 28,84% a 94,75% (4). A atividade inibitória no ensaio de difusão em disco do OE de R. officinalis foram eficazes na concentração de 100% (v/v) e apresentaram uma boa atividade antagonística em concentração de 0,5% (v/v) nas cepas de E. coli (5). O diâmetro da zona de inibição do teste de difusão em disco demonstra que o OE de R. officinalis é muito sensível contra E. coli. Foi analisado que os valores de MICs (Concentração Inibitória Mínima) e MBCs (Concentração Bactericida Mínima) do OE de R. officinalis foram iguais, indicando uma ação bactericida nos valores de MIC. Dessa forma, a atividade antibacteriana é dependente da composição química do OE, das cepas bacterianas testadas e os métodos usados. Conclusões: As propriedades antimicrobianas do OE de R. officinalis torna-o uma alternativa no controle de infecções por E. coli. Contudo, estudos adicionais são necessários para substituir os tratamentos medicinais tradicionais pelo OE de R. officinalis.
2
Formiga Caminha, Lucas Ryhan, Maria Bárbara Tenório de Macedo Barbosa, Fagner Bruno Dias Lino, Juliana Barreto, Antonio Ferreira da Silva Netto, and Josilene de Assis Cavalcante. "CINÉTICA DE SECAGEM DAS FOLHAS DO ALECRIM (Rosmarinus officinalis)." In V ENCONTRO NACIONAL DA AGROINDúSTRIA. Galoa, 2019. http://dx.doi.org/10.17648/enag-2019-115054.
Full text
3
Chernikova, Sophia A., and E. L. Malankina. "EFFECTIVENESS OF MICROFERTILIZERS APPLICATION ON ROSEMARY (ROSMARINUS OFFICINALIS L.)." In Современные тенденции развития технологий здоровьесбережения. Москва: Федеральное государственное бюджетное научное учреждение "Всероссийский научно-исследовательский институт лекарственных и ароматических растений", 2022. http://dx.doi.org/10.52101/9785870191058_103.
Full text
4
Tkachova, E. N., L. V. Kalinichenko, and E. L. Malankina. "Intrasspecific variability in raw material biochemical composition of Hyssopus officinalis L." In Растениеводство и луговодство. Тимирязевская сельскохозяйственная академия, 2020. http://dx.doi.org/10.26897/978-5-9675-1762-4-2020-174.
Full textAbstract:
It was studied the content of essential oil, flavonoids, rosmarinic acid in raw materials of 14 varieties of medicinal hyssop from different origin. The content of essential oil ranged within 0.11-0.55% in fresh raw materials, rosmarinic acid in the range of 0.49-0.80%, and flavonoids - 0.68-1.65%.
5
Silva, Maria Carolina Raiol da, and Daniel Vitor Da Silva Monteiro. "ATIVIDADES ANTIMICROBIANAS E ANTIFUNGICAS DO ÓLEO ESSENCIAL DE ALECRIM (ROSMARINUS OFFICINALIS L.)." In I Congresso Nacional de Microbiologia Clínica On-Line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1210.
Full textAbstract:
Introdução: O alecrim, é considerado popularmente como terapêutico, sobre microrganismos de notável importância clínica. A busca de produtos naturais que apresentem uma ação antifúngica eficiente frente a microrganismos resistentes se mostra uma alternativa necessária, assim como em virtude da resistência crescente aos antimicrobianos. Objetivo: Caracterizar a eficiência nas atividades antimicrobianas e antifúngicas do óleo essencial de Alecrim (Rosmarinus officinalis L.). Material e métodos: As buscas foram realizadas em bases de dados bibliográficas — SciELO, BIREME, LILACS e Livro de Fitoterapia. Incluiu-se artigos do período de janeiro de 2006 a dezembro de 2020 com delineamento experimental e observacional, em Inglês, Português e Espanhol. Resultados: As propriedades antimicrobianas do alecrim são atribuídas aos compostos pinenos, 1-8 cineol, borneol, canfeno e cânfora. Estes, geralmente, estão presentes no óleo essencial, o qual demonstrou atividade inibitória sobre as cepas de S. aureus e E. coli, quando utilizado o método de orifício em Ágar, mas não pelo método de difusão em disco, quando avaliadas as culturas de S. aureus, mas apresenta efeito bactericida para a linhagem de S. aureus. Para E. coli, foi verificada sensibilidade a este composto também no método de disco difusão. Frente a Staphylococcus spp, Enterobacter gergoviae, E. amnigenus, Lactobacillus sakei, e L. curvatus, o óleo essencial, apresentou atividade antimicrobiana, caracterizando a sua eficácia perante esses microrganismos. O óleo essencial de R. officinalis L. em relação aos fungos provoca a granulação do citoplasma, desorganização dos conteúdos celulares, rompimento da membrana plasmática e inibição das enzimas fúngicas. A partir do teste de difusão em meio sólido, atividade antifúngica sobre a cepa de C. albicans, foi identificada, assim como atividade antifúngica e antiaderente sobre C. tropicalis. No teste in vitro, mostrou-se eficiência em inibir o crescimento do A. flavus. Conclusão: Através dessa revisão bibliográfica, foi possível identificar a eficiência na atividade antimicrobiana e antifúngica do óleo essencial de Alecrim (Rosmarinus officinalis L.) diante das cepas analisadas. Porém, são necessários estudos sobre as composições e aspectos que podem comprometer a eficácia do óleo essencial, para garantir a segurança e ação do produto.
6
Belova, I. V., E. N. Grunina, and N. V. Glumova. "Prospects for the integrated processing of rosemary in the Crimea." In CURRENT STATE, PROBLEMS AND PROSPECTS OF THE DEVELOPMENT OF AGRARIAN SCIENCE. Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea”, 2020. http://dx.doi.org/10.33952/2542-0720-2020-5-9-10-4.
Full textAbstract:
A complex technology for processing raw rosemary is proposed. This technological scheme allows making maximum use of the phytopotential of Rosmarinus officinalis L. raw materials and expanding the range of essential oil products. As a result of complex processing, it is possible to obtain not only rosemary essential oil but also such additional products as natural fragrant water, aqueous and alcoholic extracts of rosemary, etc. These products will allow the processing company to gain extra income and will be in demand in various industries.
7
Cai, Tingting, Liang Wang, Kun Zhang, Zhonglong Lin, and Rong Wang. "The influence of Rosemary plants (Rosmarinus officinalis) volatiles on Aphid (Myzus Persicae)." In 2017 3rd International Forum on Energy, Environment Science and Materials (IFEESM 2017). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/ifeesm-17.2018.220.
Full text
8
Oliveira, Wanderley Pereira, Victor Oloruntoba Bankole, and Claudia Regina F. Souza. "Spray dried proliposomes of Rosmarinus officinalis polyphenols: a quality by design approach." In 21st International Drying Symposium. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7859.
Full textAbstract:
Harnessing the benefits of rosemary polyphenols is limited by variability in their physicochemical properties. These limitations may be overcome by encapsulation in systems possessing hydro-lipophilic centers thereby accommodating molecules of different polarities. Proliposomes offer a viable option in this regards, being particles which form liposomal suspension in water. Lyophilized extracts of rosemary was encapsulated in hydrogenatedsoyphosphatidylcholine/cholesterol by solvent replacement method. Spray dried proliposomes were obtained with lactose as carrier. Using Central Composite Design, the effects of lipid, extract and carrier concentrations on response variables including bioactive content and retention, moisture content characteristics, recuperation and redispersibility were evaluated by statistical analysis. Keywords: Polyphenols; antioxidant; proliposomes; spray drying
9
Briones-Concha, Jesus, Luz Irene Pascual-Mathey, Cesar Ignacio Beristain, and Luz Alicia Pascual-Pineda. "Design and characterization of liquid nanocapsules of rosemary oil (Rosmarinus officinalis L.)." In 2019 IEEE International Conference on Engineering Veracruz (ICEV). IEEE, 2019. http://dx.doi.org/10.1109/icev.2019.8920570.
Full text
10
Silva, Angela Aparecida, Idinea Fernandes Santos, Márcia Maria Anjos, Suelen Pereira Ruiz, Isabela Carolini Pascoli, Daniela Biral Prado, Jane Martha Graton Mikcha, Miguel Machinski Júnior, and Benício Alves Abreu Filho. "Avaliação da Atividade Antimicrobiana do Óleo Essencial de Rosmarinus Officinalis Frente À Alicyclobacillus Acidoterrestris." In XII Latin American Congress on Food Microbiology and Hygiene. São Paulo: Editora Edgard Blücher, 2014. http://dx.doi.org/10.5151/foodsci-microal-299.
Full textReports on the topic "Rosmarinus officinali"
1
Draganova-Filipova, Milena, Elisaveta Apostolova, and Plamen Zagorchev. Effects of Rosmarinus officinalis Oil on Histamine-induced Acute Inflammation. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, February 2018. http://dx.doi.org/10.7546/crabs.2018.02.14.
Full text
2
Draganova-Filipova, Milena, Elisaveta Apostolova, and Plamen Zagorchev. Effects of Rosmarinus officinalis Oil on Histamine-induced Acute Inflammation. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, February 2018. http://dx.doi.org/10.7546/grabs2018.2.14.
Full text
3
Todorova, Dessisava, Zornitsa Katerova, Roza Dimitrova, Maria Petrova, Marieta Hristozkova, and Iskren Sergiev. Exogenous Spermine Application Increases Quantity of Rosmarinic Acid and Carnosic Acid in Salt-treated Salvia officinalis L. Plants in Pot Experiments. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, June 2020. http://dx.doi.org/10.7546/crabs.2020.06.07.
Full text