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1

Poppitt, S., L. J. Duncan, B. Preu, F. Fazzari, and J. Archer. "The influence of volcanic rocks on the characterization of Rosebank Field – new insights from ocean-bottom seismic data and geological analogues integrated through interpretation and modelling." Geological Society, London, Petroleum Geology Conference series 8, no. 1 (December 15, 2016): 373–84. http://dx.doi.org/10.1144/pgc8.6.

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AbstractDuring Late Paleocene–Early Eocene times, the modern Rosebank structure was located at the juxtaposition of the easterly advancing Flett volcanic system and the northerly prograding Flett delta. As a result, the Rosebank reservoir sandstones are interstratified with volcanic and volcaniclastic rocks, offering challenges for reservoir imaging, depth prediction and reservoir characterization. These challenges have driven the application of Ocean Bottom Node (OBN) seismic technology. OBN data have yielded improved velocity models for depth conversion, better reservoir definition and key insights to aid the modelling of sand distribution from seismic attributes. Spectral decomposition of the OBN seismic data has facilitated the extraction of distinct volcanic subunits, whilst spectral enhancement has enabled visualization of complex stacking patterns within individual igneous layers. To complement the seismic analysis, detailed geological analogue studies have been undertaken in volcanic provinces such as the Palaeogene volcanic district of SE Greenland and the Columbia River Flood Basalt Province, USA. No single outcrop provides a definitive analogy to Rosebank, but each offers insights that provide an important link to understanding and managing the main subsurface uncertainties associated with field development. Integration of these multiple workflows have improved the reservoir characterization and provided the foundation for the optimization of the field development plan.
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2

ERBE, PETRA, and HANNELORE HOCH. "Two new species of the Australian planthopper genus Solonaima Kirkaldy (Hemiptera: Fulgoromorpha: Cixiidae)." Zootaxa 536, no. 1 (June 11, 2004): 1. http://dx.doi.org/10.11646/zootaxa.536.1.1.

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Two new epigean species of the cixiid genus Solonaima Kirkaldy, which is endemic in eastern Australia, are described from Queensland (Lamington National Park) and New South Wales (Rosebank): S. nielseni n. sp. and S. monteithia n.sp.
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3

Nuttall, S. "Stylizing the Self: The Y Generation in Rosebank, Johannesburg." Public Culture 16, no. 3 (October 1, 2004): 430–52. http://dx.doi.org/10.1215/08992363-16-3-430.

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4

Freschi, Federico. "A great seduction: The UCT Irma Stern Museum, Rosebank, Cape Town." de arte 46, no. 84 (January 2011): 92–101. http://dx.doi.org/10.1080/00043389.2011.11877156.

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5

Sætre, C., H. Hellevang, C. Dennehy, H. Dypvik, and S. Clark. "A diagenetic study of intrabasaltic siliciclastics sandstones from the Rosebank field." Marine and Petroleum Geology 98 (December 2018): 335–55. http://dx.doi.org/10.1016/j.marpetgeo.2018.08.026.

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6

Vosgerau, Henrik, Pierpaolo Guarnieri, Rikke Weibel, Michael Larsen, Brian Bell, Erik V. Sørensen, and Henrik Nøhr-Hansen. "Sedimentology and reservoir architecture of a widespread siliciclastic intra-lava unit, Kangerlussuaq, East Greenland." Journal of Sedimentary Research 91, no. 6 (June 30, 2021): 662–82. http://dx.doi.org/10.2110/jsr.2021.02.

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ABSTRACT The Rosebank hydrocarbon discovery in 2004 proved that intra-lava sandstones form attractive reservoirs in the Faroe–Shetland Basin and the new volcanic play triggered the need for suitable analogues to describe and assess sedimentology, reservoir architecture, compartmentalization, and connectivity of intra-lava siliciclastic units. The onshore Kangerlussuaq Basin in East Greenland offers the opportunity to study Paleogene intra-lava siliciclastic sandstones and their interaction with lavas, on the scale of the Rosebank Field. The focus of this study is a siliciclastic-dominated intra-lava unit, 4–10 m thick, exposed in almost vertical cliff sections over distances of several kilometers. The unit reflects a short return to siliciclastic deposition following initiation of volcanic activity and extrusion of the first lava flows in the area. Deposition took place as shoreface and delta progradation in a marine-influenced, shallow embayment. Lateral variations in sedimentary facies distribution and geometry are prominent and were largely governed by an interplay of base-level variations and autocyclic processes, the surface roughness and type of substratum on which deposition took place, and differential block movements before and during deposition. Presence of local topographic barriers are of key importance and influenced the lava–sediment interaction and the resulting 3D-geometry of lava flows and sediment bodies. In addition, compartmentalization of the intra-lava sandstone unit is observed and is controlled by the offset across normal faults, intersecting dikes, and to a lesser extent by invasive and eroding lavas. A depositional model is suggested that incorporates the detailed sedimentological and 3D photogrammetric observations and presents a possible explanation for the contrasting architecture of the intra-lava unit observed in three areas located a few kilometers apart. The model embraces the complex interplay between siliciclastic and volcanic settings and reveals important aspects to consider when recoverable volumes of hydrocarbons are estimated in intra-volcanic subsurface reservoirs in volcanic rifted margins with poor seismic imaging of the relatively thin intra-lava reservoirs.
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7

Duncan, Louise J., C. J. Dennehy, P. M. Ablard, and D. W. Wallis. "The Rosebank Field, Blocks 213/27a, 213/26b, 205/1a and 205/2a, UK Atlantic Margin." Geological Society, London, Memoirs 52, no. 1 (2020): 980–89. http://dx.doi.org/10.1144/m52-2018-42.

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AbstractThe Rosebank Field is located primarily in Block 213/27a in the Faroe–Shetland Basin, c. 130 km west of the Shetland Islands in water depths of c. 1100 m (3600 ft). Hydrocarbons are trapped within an elongate, SW–NE-trending four-way anticlinal structure. The principal Colsay Sandstone Member reservoir consists of several vertically stacked, Late Paleocene to Early Eocene fluvial and deltaic reservoirs separated by volcanic sequences. Well log and core data indicate that reservoir quality is high, with porosities in the range of 19–23% and average permeability of c. 3 D. Oil quality is also high, with average oil gravity of 37°API and in-situ viscosity of c. 1 cP at a mean reservoir temperature of 175°F. The field holds a substantial resource and is currently under evaluation for development.
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8

Hardman, Jonathon, Nick Schofield, David Jolley, Adrian Hartley, Simon Holford, and Douglas Watson. "Controls on the distribution of volcanism and intra-basaltic sediments in the Cambo–Rosebank region, West of Shetland." Petroleum Geoscience 25, no. 1 (January 17, 2018): 71–89. http://dx.doi.org/10.1144/petgeo2017-061.

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9

Du Plessis, Andries J., and Howard Frederick. "Education and Training as a Social Science: Some Empirical Evidence in the Rosebank Business Precinct of Auckland New Zealand." International Journal of Interdisciplinary Social Sciences: Annual Review 3, no. 3 (2008): 203–12. http://dx.doi.org/10.18848/1833-1882/cgp/v03i03/52566.

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10

Schofield, Nick, David Jolley, Simon Holford, Stuart Archer, Douglas Watson, Adrian Hartley, John Howell, David Muirhead, John Underhill, and Paul Green. "Challenges of future exploration within the UK Rockall Basin." Geological Society, London, Petroleum Geology Conference series 8, no. 1 (February 16, 2017): 211–29. http://dx.doi.org/10.1144/pgc8.37.

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AbstractThe UK Rockall Basin is one of the most underexplored areas of the UK Continental Shelf (UKCS), with only 12 exploration wells drilled since 1980. With only one discovery made in 2000 (Benbecula (154/1-1) gas discovery), the general view of the basin from an exploration viewpoint is not positive. However, over the last 15 years, our knowledge of the petroleum systems of the Atlantic Margin has substantially increased. With the recent acquisition of new seismic data by the UK Government as part of the OGA's Frontiers Basin Research Programme, it is a pertinent time to re-examine the prospectivity of the UK Rockall Basin.This paper presents a history of exploration within the UK Rockall Basin, from the first well drilled in the basin in 1980, to the last well, drilled in 2006. We then present new insights into the lack of success during exploration within the basin, in particular by focusing on the extensive Early Cenozoic volcanic rocks within Rockall, to illustrate the wide range of potential interactions with the petroleum system. We also present evidence that points to the potential of a viable intra-basaltic (Rosebank) type play along the eastern flank of the Rockall Basin.
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11

Worku, Yohannes Bekele, and Mammo Muchie. "The Uptake of E-Commerce Services In Johannesburg." Civil Engineering Journal 5, no. 2 (February 27, 2019): 349. http://dx.doi.org/10.28991/cej-2019-03091250.

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The aim of study was to assess the pace of adoption and quality of E-Commerce services that are provided to customers in Johannesburg, South Africa. Data was collected from 180 E-Commerce enterprises operating in Fourways, Eastgate and Rosebank. A one-way multivariate analysis of variance model (MANOVA) with maximum likelihood estimation was used for comparing the three business districts of Johannesburg with regards to the average cost of services and the average length of time required for providing services to customers. The adequacy of E-Commerce services provided to customers was assessed based on criteria defined by Bonson et al. [1]. The study showed that there was no significant difference among the three business districts of Johannesburg with regards to both variables of comparison (cost and time). The results showed that the pace of adoption of E-Commerce services in the three business districts was significantly influenced by a combination of technological and organisational factors. The study has shown that E-Commerce enterprises in Johannesburg need assistance from the City of Johannesburg in areas related to infrastructure, economic incentives, skills-based training, and monitoring and evaluation.
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12

Larsen, Michael, Brian Bell, Pierpaolo Guarnieri, Henrik Vosgerau, and Rikke Weibel. "Exploration challenges along the North Atlantic volcanic margins: the intra-volcanic sandstone play in subsurface and outcrop." Geological Society, London, Petroleum Geology Conference series 8, no. 1 (October 27, 2016): 231–45. http://dx.doi.org/10.1144/pgc8.13.

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AbstractThe margins of the North Atlantic rift are covered by an extensive succession of volcanic rocks, with up to 5 km of continental flood basalts, hyaloclastites and interbedded sedimentary rocks. The volcanic succession deteriorates seismic imaging and has hampered petroleum exploration in these areas. Focused research and pioneering exploration activity, however, has improved the understanding and development of new play models in volcanic-influenced basins. In 2004, the Rosebank discovery finally proved that intra-volcanic siliciclastic sandstones of the Flett Formation may form attractive hydrocarbon reservoirs in the Faroe–Shetland Basin.The Kangerlussuaq Basin in southern East Greenland offers a unique opportunity to study the interaction of siliciclastic sediments with lavas and various volcaniclastic units. It is demonstrated that: (1) laterally extensive siliciclastic sedimentary units are present in the lower part of the volcanic succession; (2) the morphology of the lavas controlled variations in sandstone geometry and thickness; and (3) deposition of the interbedded sediments and lavas occurred in a low-relief environment close to sea level. The mineralogical composition of the intra-volcanic sediments is highly variable, ranging from siliciclastic to purely volcaniclastic. Diagenetic studies suggest that the nature of the volcanic component in volcaniclastic sandstones is more important to reservoir properties than the relative concentration.
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13

Yang, Chengyu, and Hairuo Qing. "Possible occurrences of transition zones and residual oil zones below oil-water contacts in mature oil fields, southeast Saskatchewan." Interpretation 4, no. 4 (November 1, 2016): T591—T612. http://dx.doi.org/10.1190/int-2016-0008.1.

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A transition zone (TZ) from oil to water formed by capillary force beneath traditionally defined producing oil-water contact (OWC) has been well-known for years. Recent research and production activities in the Permian Basin and the Williston Basin in United States suggests that a residual oil zone (ROZ) may exist below traditionally defined OWC under certain geologic and hydrodynamic conditions. If this ROZ is sufficiently thick and extensive, it may be economically recoverable using tertiary recovery techniques. We have investigated possible occurrences of TZ/ROZ in the Williston Basin, southeast Saskatchewan, using well-log interpretation based on Archie’s equation. Out of 33 pools examined, we have evaluated three areas, the Bellegarde Tilston pool area, an unnamed Souris Valley pool, and the Rosebank Alida pool area, as possibly having thick (up to 47 m) low-oil-saturation TZ/ROZs below the OWCs. Evidence includes oil stains, core-based oil saturation, fluorescence on drill cuttings, and oil shows and sulfur water reported in drill stem tests. The oil in place within the possible TZ/ROZs is estimated to be approximately half the amount of the oil within their associated main pay zones. Tilted OWC and other findings may suggest that the identified oil-bearing zones are ROZs related to hydrodynamics. The hydrodynamic flows may also have created some other ROZs that still remain undiscovered.
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14

Tsuro, Lewis, and Stan Hardman. "A SOFT SYSTEMS METHODOLOGY APPROACH TO IMPROVING THE SUPPLY CHAIN OF A CONSTRUCTION PROJECT IN GAUTENG PROVINCE, SOUTH AFRICA." Journal of Construction Project Management and Innovation 10, no. 1 (September 2020): 86–99. http://dx.doi.org/10.36615/jcpmi.v10i1.342.

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The Soft Systems Methodology (SSM) was developed as a set of tools for identifying and making incremental steps to improve situations with poorly defined causes or solutions. The supply chain forms a key process of any construction project; however, on any given construction site, supply chain inefficiencies could arise from many different avenues. Opinions vary, though, on which of these avenues is more important for increasing supply chain efficiencies; whether any problem even exist across the different aspects of the supply chain; as well as what steps should be taken to resolve them. It was therefore studied, here, whether SSM could be employed as a useful tool to systematically apply in the supply chains of a construction project in South Africa, for understanding and targeting the problematic situations that arise. Following thorough cyclical open-ended interviews with 17 workers, supervisors, foremen, site clerks, senior managers, and the CEO of the principal contractor at a new office park construction project in Rosebank, Johannesburg, and a thematic analysis of the data, SSM was performed to understand the existing challenges, and develop a suitable model for improvement. The study found that SSM was a good tool for understanding the ‘messy’ circumstances surrounding the chosen construction project supply chain, as well as actions that could be taken to improve the supply chain’s efficiency on site. The findings add weight to the argument that SSM could be a good tool for project managers to systematically introduce into their project planning regimens
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15

Van Niekerk, J. P. "The Butcher of Rosebank: He had more lives than a cat, by Jon Abbott South Africa: Digital Action, 2020. ISBN 978-0-620-89984-0." South African Medical Journal 111, no. 1 (December 14, 2020): 7. http://dx.doi.org/10.7196/samj.2020.v111i1.15404.

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16

Read, Christopher. "Review: Richard Overy, The Dictators: Hitler's Germany and Stalin's Russia, Allen Lane: London, New York, Victoria, Toronto, New Delhi, Auckland, Rosebank, 2004; 849 pp., 66 illus.; 071399309X, £25/$49 (hbk)." European History Quarterly 38, no. 1 (January 2008): 172–74. http://dx.doi.org/10.1177/02656914080380010434.

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17

Belyaev, A. G., M. A. Zaikina, A. E. Kovaleva, and E. A. Pyanikova. "Study of the effect of narrow-leaved cypress extract on the properties of baking yeast." Proceedings of the Voronezh State University of Engineering Technologies 80, no. 3 (December 17, 2018): 243–47. http://dx.doi.org/10.20914/2310-1202-2018-3-243-247.

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This article presents the results of the study of the beneficial properties of narrow-leaved rosebay willowherb (Chamerion angusti folium (L.) Holub) (the contents of vitamins, minerals and other substances which positively affect the human body). The process of extraction of a narrow-leaved spray from a dry plant raw material with an aqueous solution was looked at. The investigation of the concentration of narrow-leaved rosebay willowherb in an aqueous solution using a refractometer revealed that a 20 min. infusion shows the constant growth of dry matter in the extract. However after the 20 min. period the concentration of solids stays constant. Therefore, the optimum infusion time was set to 20 min. As a result of the study, the accelerated method of lifting the pressed yeast using an aqueous solution and a lemon grass extract revealed that, with the addition of the plant additive, the lifting power of the yeast decreased by 10.5%.This indicates that the products of narrow-leaved rosebay willowherb favorably affect yeast cells. Yeast suspensions from water and yeast and aqueous extract of narrow-leaved rosebay willowherb and yeast spray have been studied. After 60 min. of thermostating and further microscope study, with the determination of the concentration of yeast cells with the help of Goryaev's chamber, allowed to establish that the concentration of yeast cells in suspension with the extract of narrow-leaved rosebay willowherb exceeds the concentration in the control suspension by almost 1.5 times. This phenomenon is caused by the stimulating effect of the individual components that make up the narrow-leaved rosebay willowherb (sugars, vitamins, minerals and other components), which are an additional source of energy. It is proposed to use the spray extract of the narrow-leaved rosebay willowherb as a raw material in the preparation of bakery products for preventive purposes.
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18

Danilin, S. I., S. L. Kuzmenko, Yu V. Rodionov, and E. I. Kargin. "Development of adaptive technology for cultivation and processing of rosebay willow-herb (Chamaenérionangustifolium)." IOP Conference Series: Earth and Environmental Science 845, no. 1 (November 1, 2021): 012038. http://dx.doi.org/10.1088/1755-1315/845/1/012038.

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Abstract The propagation methods of rosebay willow-herb were studied on the basis of theoretical and experimental studies, the optimal size of the feeding area of one plant in a field was described and established. The efficiency of cultivating these plants depending on the time of sowing in winter greenhouses and the field planting scheme was determined, scientific and practical justification of the feasibility of cultivating rosebay willow-herb as a raw material for the processing industry in the North-Eastern part of Tambov Region was given in order to obtain dry vegetable concentrate for the production of soft drinks, syrups, natural additives for functional enrichment of food products. A non-waste concentrate production technology was developed and implemented using gentle modes and intensive processes, such as two-stage vacuum-pulse drying, vacuum extraction.
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19

Plocher, Allen E., and Kenneth L. Carvell. "Population Dynamics of Rosebay Rhododendron Thickets in the Southern Appalachians." Bulletin of the Torrey Botanical Club 114, no. 2 (April 1987): 121. http://dx.doi.org/10.2307/2996120.

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20

Jariene, Elvyra, Marius Lasinskas, Honorata Danilcenko, Nijole Vaitkeviciene, Alvyra Slepetiene, Katarzyna Najman, and Ewelina Hallmann. "Polyphenols, Antioxidant Activity and Volatile Compounds in Fermented Leaves of Medicinal Plant Rosebay Willowherb (Chamerion angustifolium (L.) Holub)." Plants 9, no. 12 (December 1, 2020): 1683. http://dx.doi.org/10.3390/plants9121683.

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At present, the consumption of medical plants and functional foods is growing in the whole world. Rosebay willowherb (Chamerionangustifolium (L.) Holub) is an important medicinal plant that has various pharmacological effects (antioxidant, anti-inflammatory, anticancer, and others), can improve the state of health and well-being, and reduce the risk of various diseases. The aim of this work was to investigate volatile compounds, polyphenols, and antioxidant activity in rosebay willowherb leaves fermented for 24 and 48 h in solid state fermentation under aerobic and anaerobic conditions. High-performance liquid chromatography (HPLC) for polyphenols and the spectrophotometric method for antioxidant activity determinations were used. To recognize and identify the leaves’ fragrances, electronic nose (Alpha M.O.S) measurement technology was used. The results showed that the highest amounts of total polyphenols in dried matter were after 48 h aerobic solid state fermentation (SSF). Antioxidant activity was higher under 48 h SSF compared to the control. The most abundant flavoring compound groups were esters, terpenes, and aldehydes. In unfermented leaves, (z)-3-hexen-1-ol, acetate, hexyl acetate, and trans-hex-2-enyl acetate prevailed, characterized by fragrances of greenery, flowers, and fruits. The undesired esters group compounds, ethyl butyrate and butyl acetate, with pungent odor, were detected after 48 h anaerobic SSF.
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21

Olennikov, Daniil, Lubov' Dudareva, Semion Osipenko, and Tat'yana Penzina. "Chemical composition of Rhododendron aureum (Gold rosebay) essential oil from Pribaikal'e (Russian Federation)." Journal of the Serbian Chemical Society 75, no. 2 (2010): 209–15. http://dx.doi.org/10.2298/jsc1002209o.

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The essential oils from five samples of leaves of Rhododendron aureum from the Irkutsk region, Pribaikal'e, Russian Federation, were isolated by hydrodistillation and analyzed by a combination of GC and GC/MS. Compounds representing 70.5-78.3 % of the oils were identified. Twenty-seven compounds were identified according to their chromatographic retention indices and mass spectra. The major components of the oils were calarene (10.4- -66.4 %), ?-bourbonene (0.5-27.4 %), ?-selinene (2.1-8.0 %) and kaur-16-ene (2.0-6.3 %). It was found that the chemical composition of Rh. aureum essential oil depends on the altitude of the growing plants.
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22

Starrett, Mark C., Frank A. Blazich, and Stuart L. Warren. "Initial Growth of Rosebay Rhododendron Seedlings as Influenced by Day and Night Temperatures." HortScience 28, no. 7 (July 1993): 705–7. http://dx.doi.org/10.21273/hortsci.28.7.705.

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Rosebay rhododendron (Rhododendron maximum L.) seedlings were grown in controlled-environment chambers for 14 weeks under long (9-hour) days at 18, 22, 26, or 30C in factorial combination with 15-hour nights at 14, 18, 22, or 26C. Total dry-matter production was lowest for 18C days and highest for 26C days. A similar response occurred for top, leaf, root, and stem dry weights. Nights at 22C maximized total plant, top, leaf, and stem dry weights. The optimum day/night cycle for dry-matter production was 26/22C. Leaf area was optimum with 18C nights. Leaf weight ratio (leaf dry weight: total plant dry weight) increased with an increase in night temperature to a maximum at 22C. Root weight ratio (root dry weight: total plant dry weight) decreased with an increase in night temperature to a minimum at 22C. Stem weight ratio (stem dry weight: total plant dry weight) and shoot: root ratio (top dry weight: root dry weight) were not influenced significantly by day or night temperature. A day/night cycle of 26/22C seems to be optimal for producing-salable plants.
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23

박군석. "A Study on presentation of inner self revealed in Kim, So-Wol’s anthology Korean Rosebay." Korean Poetics Studies ll, no. 44 (December 2015): 159–200. http://dx.doi.org/10.15705/kopoet..44.201512.006.

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24

Shi, Hailin, Shiwei Sun, Xiaohong Liu, Jiahe Fan, Jin Wang, Ke Zhao, and Wei Wang. "Allelopathic Potential and Mechanism of Rosebay Willowherb [Chamaenerion angustifolium (L.) Scop.] Demonstrated on Model Plant Lettuce." Phyton 90, no. 1 (2021): 159–70. http://dx.doi.org/10.32604/phyton.2020.011620.

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25

Riani, Lilia Pasca, and Hery Purnomo. "IMPLEMENTASI KOMBINASI 3IC Tools SEBAGAI PENENTU OPTIMASI PENGENDALIAN PERSEDIAAN MINYAK GORENG." BISMA 13, no. 1 (March 26, 2019): 10. http://dx.doi.org/10.19184/bisma.v13i1.9401.

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The purposes of this study are: (1) to classify the brand of the cooking oil product in the class A category using ABC method, (2) to identify the safety stock level of the inventory, and (3) to determine the highest reorder point for the cooking oil product in class A. This research is a descriptive research with quantitative approach. Data were collected based on observational studies and interviews. Data analysis was performed using 3IC tools divided into three stages: first, ABC analysis to classify product class in class A, B, or C; second, calculating the safety stock level for the class A cooking oil; and third, determining the reorder point. The results showed that of the 86 cooking oil’s brands and packagings, 28 brands were classified in class A; the highest safety stock calculation was on Sedaap brand cooking oil packaged in 2 liter refill, and the highest reorder point level was on the Rosebrand cooking oil packaged in 1 liter refill. Keywords : Cooking oil, 3IC tools, ABC method, safety stock, reorder point.
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PÄÄKKÖNEN, K. "A combined infrared/heat pump drying technology applied to a rotary dryer." Agricultural and Food Science 11, no. 3 (January 3, 2002): 209–18. http://dx.doi.org/10.23986/afsci.5726.

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The short drying time and low product temperature makes it suitable for drying such heat-sensitive materials as herbs and vegetables. The purpose of this work was to develop a small-scale dryer for herbs and vegetables. A prototype rotary dryer combining infrared radiation with a so-called heat pump drying method was applied in drying experiments for several herbs and vegetables. The drying experiments were performed under actual crop production conditions. The drying curves for leaves of birch (Betula spp.), rosebay willowherb (Epilobium angustifolium) and dandelion (Taraxacum spp.) as well as slices of red beet (Beta vulgaris) and carrot (Daucus carota) are presented. During the drying operation, temperature and humidity of the drying air were recorded, as well as the energy consumed in drying. The quality parameters measured were water content, colour and rehydration ratio. In the present rotary dryer design, intermittent irradiation and mixing of the product enable to avoid overheating, which is particularly important for maintaining product quality. In this dryer design the drying drum slowly rotates and simultaneously mixes the product. The infrared heaters are attached to a panel, allowing the product to receive infrared radiation periodically.
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Abdolzadeh, Ahmad, Kazuto Shima, Hans Lambers, and Kyozo Chiba. "Change in Uptake, Transport and Accumulation of Ions in Nerium oleander (Rosebay) as Affected by Different Nitrogen Sources and Salinity." Annals of Botany 102, no. 5 (September 4, 2008): 735–46. http://dx.doi.org/10.1093/aob/mcn156.

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28

Craig, Adam. "Exploration and appraisal year in review 2021." APPEA Journal 62, no. 2 (May 13, 2022): S527—S536. http://dx.doi.org/10.1071/aj21222.

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Petroleum exploration and appraisal activity increased in 2021. Exploration spend increased for the year, continuing a positive trend. Onshore exploration and appraisal activity continues to dominate the petroleum exploration scene in Australia. Positive indications of increased work program bids (wells, seismic and spend) are, however, tempered by the downward trend of total exploration acreage (by area) and new acreage awards. In addition to petroleum exploration acreage, greenhouse gas sequestration acreage was released across Australia in 2021. Twenty-nine exploration wells were drilled in the year compared to twenty-five in the previous year. Eight conventional petroleum discoveries were reported, with the Artisan-1 discovery in the Otway Basin being the only offshore discovery. The Lockyer Deep-1 gas discovery in the Northern Perth Basin continues the exploration success of the Permian Kingia and High Cliff Sandstone play. The Cooper–Eromanga Basin continues to yield discoveries with the Odin-1, Rosebay-1, Lowry South, Liger-1 and Chimera-1 discoveries reported for the year. Thirty-one appraisal wells were drilled for the year with significant activity in the Northern Perth Basin, Cooper-Eromanga Basin and Bowen-Surat Basins. Exploration and appraisal drilling also continued in the Beetaloo Sub-basin with the drilling of the Tanumbirini-2H, Tanumbirini-3H and Carpentaria-2/2H wells during the year.
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Lee, Ha Kyung, So Jeong Lee, Min Kyung Kim, and Sang Don Lee. "Prediction of Plant Phenological Shift under Climate Change in South Korea." Sustainability 12, no. 21 (November 8, 2020): 9276. http://dx.doi.org/10.3390/su12219276.

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Information on the phenological shift of plants can be used to detect climate change and predict changes in the ecosystem. In this study, the changes in first flowering dates (FFDs) of the plum tree (Prunus mume), Korean forsythia (Forsythia koreana), Korean rosebay (Rhododendron mucronulatum), cherry tree (Prunus yedoensis), and peach tree (Prunus persica) in Korea during 1920–2019 were investigated. In addition, the changes in the climatic factors (temperature and precipitation) and their relationship with the FFDs were analyzed. The changes in the temperature and precipitation during the January–February–March period and the phenological shifts of all research species during 1920–2019 indicate that warm and dry spring weather advances the FFDs. Moreover, the temperature has a greater impact on this phenological shift than precipitation. Earlier flowering species are more likely to advance their FFDs than later flowering species. Hence, the temporal asynchrony among plant species will become worse with climate change. In addition, the FFDs in 2100 were predicted based on representative concentration pathway (RCP) scenarios. The difference between the predicted FFDs of the RCP 4.5 and RCP 6.0 for 2100 was significant; the effectiveness of greenhouse gas policies will presumably determine the degree of the plant phenological shift in the future. Furthermore, we presented the predicted FFDs for 2100.
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30

Mulroy, Meghan L., Eric J. Holzmueller, and Michael A. Jenkins. "Woody Regeneration Response to Overstory Mortality Caused by the Hemlock Woolly Adelgid (Adelges tsugae) in the Southern Appalachian Mountains." Forests 10, no. 9 (August 21, 2019): 717. http://dx.doi.org/10.3390/f10090717.

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Adelges tsugae Annand (hemlock woolly adelgid, HWA, an invasive insect native to Japan), which causes defoliation and death of Tsuga canadensis (L.) Carrière (eastern hemlock), was introduced to the United States in the early 1950s and has spread throughout much of the range of T. canadensis causing widespread mortality. In 2016 and 2017, we resampled long-term vegetation monitoring plots across five forest types (ecogroups) within Great Smoky Mountains National Park that contained T. canadensis in 2003 (prior to the spread of HWA within the park) to examine changes in the species composition and diversity of the regeneration layer. We hypothesized that compositional changes in the seedling and sapling strata would be driven primarily by the pre-HWA importance value of T. canadensis and relative dominance of Rhododendron maximum L. (rosebay rhododendron), and that species diversity metrics would differ across year depending on ecogroup and the relative dominance of R. maximum. Non-metric multi-dimensional scaling (NMDS) revealed that the seedling and sapling strata of plots with greater pre-HWA importance of T. canadensis and lower basal area of R. maximum generally exhibited greater compositional change between 2003 and 2017. Topo-edaphic variables were also significant in both NMDS ordinations and were associated with the distribution of multiple hardwood species. Species richness, evenness, and Shannon-Wiener diversity varied with strata following the loss of T. canadensis, with the degree and direction of change varying with the dominance of R. maximum.
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Kulmala, L., J. Pumpanen, T. Vesala, and P. Hari. "Photosynthetic production of boreal ground vegetation after a forest clear-cut." Biogeosciences Discussions 6, no. 3 (May 5, 2009): 4603–37. http://dx.doi.org/10.5194/bgd-6-4603-2009.

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Abstract. Heather (Calluna vulgaris), rosebay willowherb (Epilobium angustifolium), wavy hair-grass (Deschampsia flexuosa) and raspberry (Rubus idaeus) are typical species on boreal clear-cut sites. According to our study, they all had clear and species-specific annual cycles of photosynthetic activity (Pmax). The maxima of C. vulgaris and E. angustifolium occurred around June and July, while that of R. idaeus occurred as late as in August. The photosynthetic activity of C. vulgaris followed the temperature history closely when the soil moisture was high. Deciduous D. flexuosa also followed the temperature history, unlike E. angustifolium and R. idaeus. During a short drought, some shoots decreased their Pmax levels but none of the species showed congruent reactions within individuals. In general, we noticed that the comparison of Pmax or respiration of different shoots caused less discrepancy when based on ground area than on leaf mass. Using species composition and continuous temperature and light measurements, we upscaled the species-specific process rates and integrated fixed and respired CO2 of ground vegetation during an entire growing season 2005. The photosynthetic production of ground vegetation was 760 g C m−2 y−1 at the fertile site and 300 g C m−2 y−1 at the infertile site. During the snow-free period (18 April–21 November), C. vulgaris respired 68 g C m−2 y−1 and E. angustifolium 7 g C m−2 y−1 at the infertile site. At the fertile site, E. angustifolium and R. idaeus respired 22 and 12 g C m−2 y−1, respectively.
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32

Perry, Robin. "Protection of Sensitive Coastal Areas in the United Kingdom: From Torrey Canyon to the New Millenium1." International Oil Spill Conference Proceedings 1999, no. 1 (March 1, 1999): 149–63. http://dx.doi.org/10.7901/2169-3358-1999-1-149.

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ABSTRACT The tanker Torrey Canyon grounded in 1967 beginning the era of the major oil spill. The United Kingdom was unprepared for this event. Nevertheless, following the spill, much research was carried out, including methods for the protection of environmental and socio-economic sensitive areas. However, little was done to produce detailed protection plans for such sites. These can save hours of response time, as boom locations, priorities, layouts, deployment methods, equipment requirements, access and temporary oil storage arrangements will be specified. Yet in the United Kingdom, the Shoreline Response Centre (Command Centre) continued to decide these things after the spill had occurred, which was often too late. In 1990, a spill from the tanker Rosebay occurred in the English Channel, off the sensitive South Devon coast. Protection plans were non-existent. This gave an impetus to develop coastal protection planning, which the SW Region of the National Rivers Authority (NRA) commenced. In 1995, it was recommended that this should be extended throughout the United Kingdom to a common standard. Unfortunately, various factors delayed commencement of this work, which was jointly carried out in 1998 by the Environment Agency (EA), the successor to the NRA, the Maritime and Coastguard Agency, Marine Pollution Control Unit and the Northern Ireland Environment and Heritage Service. In the meantime, many unsatisfactory plans were produced for the upstream oil industry. The paper reviews this background and describes the new national coastal protection planning guidelines. It also includes completed examples, describes the testing and validation process and describes future plans.
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33

Dickerson, N. T. "The Housing Divide: How Generations of Immigrants Fare in New York's Housing Market By Emily Rosebaum and Samantha Friedman New York University Press. 2007. 309 pages. $45 cloth." Social Forces 87, no. 1 (September 1, 2008): 599–600. http://dx.doi.org/10.1353/sof.0.0075.

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Kim, Minkyung, Sojeong Lee, Hakyung Lee, and Sangdon Lee. "Phenological Response in the Trophic Levels to Climate Change in Korea." International Journal of Environmental Research and Public Health 18, no. 3 (January 26, 2021): 1086. http://dx.doi.org/10.3390/ijerph18031086.

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The response of the phenological events of individual species to climate change is not isolated, but is connected through interaction with other species at the same or adjacent trophic level. Using long-term phenological data observed since 1976 in Korea, whose temperature has risen more steeply than the average global temperature, this study conducted phenological analysis (differ-ences in the phenology of groups, differences in phenological shifts due to climate change, differ-ences in phenological sensitivity to climate by groups, and the change of phenological day differ-ences among interacting groups). The phenological shift of the producer group (plants) was found to be negative in all researched species, which means that it blooms quickly over the years. The regression slope of consumers (primary consumers and secondary consumers) was generally posi-tive which means that the phenological events of these species tended to be later during the study period. The inter-regional deviation of phenological events was not large for any plant except for plum tree and Black locust. In addition, regional variations in high trophic levels of secondary consumers tended to be greater than that of producers and primary consumers. Among the studied species, plum was the most sensitive to temperature, and when the temperature rose by 1 °C, the flowering time of plum decreased by 7.20 days. As a result of checking the day differences in the phenological events of the interacting species, the phenological events of species were reversed, and butterflies have appeared earlier than plum, Korean forsythia, and Korean rosebay since 1990. Using long-term data from Korea, this study investigated differences in phenological reactions among trophic groups. There is a possibility of a phenological mismatch between trophic groups in the future if global warming continues due to differences in sensitivity to climate and phenological shifts between trophic levels.
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35

Kulmala, L., J. Pumpanen, T. Vesala, and P. Hari. "Photosynthesis of boreal ground vegetation after a forest clear-cut." Biogeosciences 6, no. 11 (November 6, 2009): 2495–507. http://dx.doi.org/10.5194/bg-6-2495-2009.

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Abstract. Heather (Calluna vulgaris), rosebay willowherb (Epilobium angustifolium), wavy hair-grass (Deschampsia flexuosa) and raspberry (Rubus idaeus) are typical species at boreal clear-cut sites. In this study, we measured their photosynthesis separately in the growing season of 2005 using a manual chamber. All measured species showed clear and species-specific seasonal cycles of photosynthetic activity (Pmax). The maxima of C. vulgaris and E. angustifolium occurred around June and July, while that of R. idaeus occurred as late as August. A simple model of photosynthetic activity is presented, addressing the photosynthesis of C. vulgaris was mainly explained by temperature history when the soil moisture is high. The activity of deciduous D. flexuosa also followed the temperature history, unlike the activities of E. angustifolium and R. idaeus. During a short drought, some shoots decreased their Pmax levels but none of the species showed similar reactions between individuals. We also observed that the comparison of the whole-plant Pmax or respiration of different-sized individuals were less scattered than the results based on full-grown leaf mass, implying that species-specific rates of photosynthesis at ground level are rather similar regardless of the plant size. Using species composition and continuous temperature and light measurements, we upscaled the species-specific process rates and integrated fixed and respired CO2 of ground vegetation for the entire 2005 growing season. The photosynthetic production per surface area of soil was 760 g C m−2 y−1 at the fertile site and 300 g C m−2 y−1 at the infertile site. During the snow-free period (18 April–21 November), the above ground parts of measured species released 75 g C m−2 y−1 at the infertile site. At the fertile site, E. angustifolium and R. idaeus respired 22 and 12 g C m−2 y−1, respectively.
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36

IGNATOVICH, Larisa S., Elena V. GINTER, Aleksandr S. LYKOV, Irina Yu KUZMINA, and Svetlana B. KUSTOVA. "THE USE OF NON-CONVENTIONAL SUPPLEMENTARY FEEDS IN CATTLE AND LAYER DIET." Periódico Tchê Química 16, no. 32 (August 20, 2019): 668–87. http://dx.doi.org/10.52571/ptq.v16.n32.2019.686_periodico32_pgs_668_687.pdf.

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It was undertook a number of studies on the effects of introducing new non-conventional vegetable supplementary feeds in the diets of dairy cows and industrial laying hens. Plants are not cultivated for their production, but they refer to wild crops growing in the natural habitat in sufficient quantities. The purpose of the research was to determine the effect of introducing non-conventional vegetable supplementary feeds on the productive qualities of cows and laying hens; quality of products (milk, eggs); nutrient digestibility (use) of laying hens and reproductive functions of cows; and to identify the economic efficiency of using these supplementary feeds by changing feed conversion ratio. The composition of supplementary feeds for cows included sea furbelow, creeping pine needles, lichens. Supplementary feeds consisting of sea furbelow flour and wild crops were introduced into the diet of laying hens: fireweed or rosebay willowherb, stinging nettle, and creeping pine needles. The studies were conducted at the agricultural enterprises. The experiments were performed on Ayrshire and Holstein cows of different lactation periods and the Hisex White laying hens of various age and productive periods. Randomized regimens were used, including 2-5 levels of feeding. The groups of cows were formed by the analog to pair matching method; laying hens were formed by the analog to group matching method and were kept in equal zoohygienic conditions. During group formation, no significant differences in body weight and productivity between the formed groups were revealed (P> 0.05), which indicates the correct selection of groups for the research. As a result, cows improved reproductive functions, increased milk yield, milk fat content and feed conversion; hens showed the intensification of metabolic processes, contributing to an increase in productivity, feed conversion and egg quality (P 0.05), which indicates the effectiveness of using new supplementary feeds.
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37

Glenn, Christopher T., Frank A. Blazich, and Stuart L. Warren. "Influence of Storage Temperatures on Long-term Seed Viability of Selected Native Ericaceous Species." Journal of Environmental Horticulture 16, no. 3 (September 1, 1998): 166–72. http://dx.doi.org/10.24266/0738-2898-16.3.166.

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Abstract Following harvest of capsules, drying, and seed extraction, seeds of Kalmia latifolia L. (mountain laurel), Leucothoe fontanesiana (Steud.) Sleum (drooping leucothoe), Rhododendron carolinianum Rehd. (Carolina rhododendron), Rhododendron catawbiense Michx. (Catawba rhododendron), and Rhododendron maximum L. (rosebay rhododendron) were stored for 0, 1, 2, 3, 4 or 5 years at −18,4 or 23C (0, 39 or 73F) and then germinated at 25C (77F) or an 8/16 hr thermoperiod of 25/15C (77/59F) with daily photoperiods of 0, 1 or 24 hr. Storage at −18 or 4C (0 or 39F) were most effective for maintaining seed viability of all species. After 5 years storage at −18 or 4C (0 or 39F), viability of L. fontanesiana, R. catawbiense, and R. maximum was relatively unchanged with total germination of 59%, 87%, and 88%, respectively. The same was noted for seeds of K. latifolia and R. carolinianum with total germination of 77% and 91%, respectively, after storage for 4 years at the same temperatures. Storage at 23C (73F) was the least effective for maintaining viability. After storage for 1 year at 23C (73F), germination decreased significantly for all species except R. carolinianum. By year 3, storage at 23C (73F) reduced seed viability of L. fontanesiana to essentially zero. The same occurred by year 4 for seeds of R. catawbiense and R. maximum stored at 23C (73F). Viability of K. latifolia also decreased under storage at 23C (73F) with germination of 14% noted by year 4. Viability of R. carolinianum did not decrease as rapidly as the other species when stored at 23C (73F) with total germination of 77% occurring by year 4. Regardless of storage duration, the photoperiod and temperature requirements for maximum germination of all species did not change.
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Glenn, Christopher T., Frank A. Blazich, and Stuart L. Warren. "Secondary Seed Dormancy of Rhododendron catawbiense and Rhododendron maximum." Journal of Environmental Horticulture 17, no. 1 (March 1, 1999): 1–4. http://dx.doi.org/10.24266/0738-2898-17.1.1.

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Abstract Seeds of Rhododendron catawbiense Michx. (Catawba rhododendron) and Rhododendron maximum L. (rosebay rhododendron) were germinated at 25C (77F) or an 8/16 hr thermoperiod of 25/15C (77/59F) with constant light after imbibed seeds were maintained in total darkness for 0, 9, 18, 27, 36, 45, 54 or 63 days at the same temperatures. Maintenance of imbibed seeds of R. catawbiense in darkness at 25C (77F) for up to 63 days caused no induction of secondary dormancy while induction occurred for seeds in darkness at 25/15C (77/59F). When imbibed seeds of R. catawbiense were subjected immediately to light following imbibition, 30-day germination at 25C (77F) was 98% compared to 95% for imbibed seeds maintained in darkness for 63 days and then exposed to light. If germinated at 25/15C (77/59F), immediate light exposure resulted in 99% germination which decreased significantly to 76% after 63 days of dark treatment. Seeds of R. maximum maintained in darkness developed secondary dormancy at both temperatures. Thirty day germination of seeds subjected immediately to light following imbibition at 25C (77F) was 82% which decreased to 29% after dark treatment for 9 days. Further reductions in germination continued as the length of dark treatment increased with < 10% germination after maintenance in darkness for 27 days. At 25/15C (77/59F) induction of secondary dormancy was not as dramatic as that at 25C (77F). Without dark treatment, 30-day germination at 25/15C (77/59F) was 99% which decreased significantly to 88% after dark treatment for 18 days. Reductions in germination continued up to 63 days with 67% germination. Partial removal of secondary dormancy in seeds of R. maximum was achieved by subjecting seeds to moist-chilling.
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39

Spetich, Martin A., Michael A. Jenkins, Stephen R. Shifley, Robert F. Wittwer, and David L. Graney. "Characteristics of Dry-Mesic Old-Growth Oak Forests in the Eastern United States." Earth 3, no. 3 (September 13, 2022): 975–1009. http://dx.doi.org/10.3390/earth3030057.

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Dry-mesic old-growth oak forests are widely distributed remnants across the eastern U.S. and are expected to increase in number and extent as second-growth forests mature. In this study, we synthesize published and unpublished information to better define the species, structure and extent of these forests. Mean site tree density for trees ≥10 cm dbh ranged from 341–620 trees ha−1. In the eastern part of the region, most stand basal areas were >23 m2 ha−1, compared to ≤23 m2 ha−1 in the westernmost stands. Overall, woody species diversity was relatively low compared to old-growth oak forests on moister sites, with tree species per forest ranging from 5–18. The most common species among the stands were white oak (Quercus alba), northern red oak (Quercus rubra), and black oak (Quercus velutina). Shrub and vine species per forest ranged from 1–10, with common species or genera including Virginia creeper (Parthenocissus quinquefolia), poison ivy (Toxicodendron radicans), Vaccinium spp., and grapevines (Vitis spp.). Within the southern Appalachian Mountains, rosebay rhododendron (Rhododendron maximum) and mountain laurel (Kalmia latifolia L.) were common. Herbaceous species per stand ranged from 4–51, with the highest richness occurring in a southern Appalachian oak-hickory forest. The maximum within-stand age of the large trees ranged from 170 to over 365 years. The mean density of standing dead trees ≥10 cm dbh ranged from 31–78 ha−1 and the volume of coarse woody debris ≥10 cm in diameter averaged 52 m3 ha−1. We more fully describe the characteristics of these forests and fill gaps in the collective knowledge of this increasingly important forest type. However, over the past 20 years, there has been scant research on these forests, and older research studies have used a variety of research plots and methods. A uniform approach to surveying these sites is needed to gain a better understanding of these forests before we are faced with caring for an increase in old-growth forest areas.
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40

Jakubowiak, Andrzej, Jagoda Jasielec, Cara A. Rosenbaum, Jeffrey A. Zonder, Craig E. Cole, Ajai Chari, Jennifer Nam, et al. "Phase 1 MMRC Trial of Selinexor, Carfilzomib (CFZ), and Dexamethasone (DEX) in Relapsed and Relapsed/Refractory Multiple Myeloma (RRMM)." Blood 126, no. 23 (December 3, 2015): 4223. http://dx.doi.org/10.1182/blood.v126.23.4223.4223.

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Abstract Background There is an increasing number of multiple myeloma patients (pts) refractory to currently available drugs, including the proteasome inhibitors bortezomib and Carfilzomib (CFZ), necessitating development of novel effective therapeutics. Pre-clinical evaluation of selinexor, a novel orally available selective inhibitor of nuclear export (SINE), in human myeloma cell lines (HMCL), primary plasma cells derived from myeloma patients, and HMCL tumor-bearing mice demonstrated synergistic myeloma cell death with CFZ (Rosebeck et al. ASH 2013) and the ability to overcome resistance to CFZ (Rosebeck et al. ASH 2014). Aims The primary objective is to assess the maximum tolerated dose (MTD) of selinexor and CFZ in combination with DEX in RRMM pts and to provide preliminary evaluation of efficacy of this novel triplet regimen. Methods Pts with RRMM, including CFZ-refractory pts, who have failed at least two prior treatment regimens of myeloma therapy, were eligible for enrollment. Dose escalation follows the 3+3 design with pts receiving 30 mg/m2 - 40 mg/m2 selinexor PO on days 1, 3, 8, 10, 15, 17; 20 mg/m2 - 56 mg/m2 CFZ given IV on days 1, 2, 8, 9, 15, 16, and DEX PO 20/10mg (cycles 1-4/cycles 5+) in 28-day cycles. At least 12 and up to 48 pts are planned for evaluation. Dose Limiting Toxicities (DLT) are measured for the Cycle 1 as well as Day 1 of Cycle 2. Dose modifications are allowed to manage toxicities. Response was assessed by IMWG criteria plus near complete response (nCR). Results As of July 1st, 2015 the study has enrolled 8 pts, 5 pts were treated at dose level 1 (30 mg/m2 selinexor, 20/27 mg/m2 CFZ, 20/10 mg DEX) and 3 patients were treated at dose level 2a (30 mg/m2 selinexor, 20/36 mg/m2 CFZ, 20/10 mg DEX). Pts had median age of 65.5 (range 55-73) and a median of 5 prior treatment regimens (range 2-5). Six pts were refractory to CFZ combinations at their last line of therapy, including 4 to CFZ, pomalidomide (POM), and DEX. Of the 2 remaining pts, 1 was refractory to high dose CFZ with DEX in prior line of therapy and both were refractory to last line of therapy. Six pts were DLT-evaluable and two pts required replacement for DLT evaluation (1 pt had DEX reduced in cycle 1 not due to DLT; 1 pt did not receive all scheduled cycle 1 doses due to progressive disease). There have been no DLTs and MTD is not yet established. Adverse events (AEs) were reversible and managed with concomitant therapy. G3/4 hematologic AEs include thrombocytopenia (75%), neutropenia (50%), leukopenia (37.5%), lymphopenia (25%), and anemia (25%). The most common G3/4 non-hematologic AEs included fatigue (25%) and upper respiratory tract infection (25%). The most common G1/2 AEs are fatigue (75%), dyspnea (62.5%), nausea (62.5%), anemia (50%), leukopenia (50%), and thrombocytopenia (50%). Response rates for all enrolled pts are 87.5% ≥MR, 75% ≥PR, 12.5% ≥VGPR. Responses occurred rapidly; after 1 cycle: 75% ≥MR, 63% ≥PR, 12.5% VGPR. As of the cut off date, 4 pts have progressed (after 1, 2, 4, and 4 months) and 4 pts remain on treatment (10+, 1+, 1+, and 1+ months); 1 pt did not respond and died due to progression of disease. Conclusions Although still very early, the combination of selinexor, CFZ, and DEX demonstrates encouraging activity with 75% PR or better and no unexpected toxicities in highly refractory MM pts, including those previously refractory to CFZ. Responses in pts refractory to very active CFZ combinations in the last line of therapy suggest that this regimen has the ability to overcome CFZ resistance. Disclosures Jakubowiak: Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; SkylineDx: Membership on an entity's Board of Directors or advisory committees; SkylineDx: Membership on an entity's Board of Directors or advisory committees; Karyopharm: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Sanofi-Aventis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Bristol-Myers Squibb: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: institutional funding for support of clinical trial conduct, Speakers Bureau; Millennium: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Onyx: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Karyopharm: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Onyx: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Millennium: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Sanofi-Aventis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. Off Label Use: The combination of Carfilzomib and Selinexor is being used for the treatment of Multiple Myeloma. Rosenbaum:Celgene: Speakers Bureau. Zonder:Celgene: Membership on an entity's Board of Directors or advisory committees, Other: research support; Prothena: Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Membership on an entity's Board of Directors or advisory committees; BMS: Membership on an entity's Board of Directors or advisory committees. Chari:Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Array BioPharma: Consultancy, Research Funding; Onyx: Consultancy, Research Funding; Millenium/Takeda: Consultancy, Research Funding; Novartis: Consultancy, Research Funding. Rashal:Karyopharm Therapeutics Inc: Employment. Youssoufian:Karyopharm Therapeutics Inc: Employment. Henry:Karyopharm: Employment, Equity Ownership. Shacham:Karyopharm: Employment, Equity Ownership. Kauffman:Karyopharm: Employment, Equity Ownership.
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Rosebeck, Shaun, Mattina Alonge, Jagoda Jasielec, Dilara McCauley, Sharon Shacham, Michael Kauffman, and Andrzej Jakubowiak. "Anti-Myeloma Activity of Combined Inhibition of the Proteasome with Carfilzomib (CFZ) and XPO1/CRM1-Dependent Nuclear Export By Selinexor (KPT-330) Via a Novel Mechanism of Intracellular Activation of Caspase 10-Dependent Apoptosis." Blood 124, no. 21 (December 6, 2014): 3443. http://dx.doi.org/10.1182/blood.v124.21.3443.3443.

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Abstract INTRODUCTION Previously, our work highlighted the synergistic activity of combining the selective inhibitor of nuclear export (SINE) selinexor with the irreversible proteasome inhibitor (PI) CFZ in multiple myeloma (MM) patient-derived plasma cells and cell lines, and in a murine xenograft model (Rosebeck et al, Blood 2013:122(21):279). Our studies were the first to suggest a role for both autophagy and apoptosis in response to combined SINE/PI treatment. Importantly, our results served as pre-clinical rationale for a currently-enrolling phase I clinical trial for the treatment of refractory and/or relapsed MM (NCT02199665). To gain insight into the molecular mechanism of synergy, we explored the novel role of caspase 10, which was implicated in our previous work, in the cytotoxic effects of combined KPT-330/CFZ treatment. METHODS MM cell lines were grown in RPMI1640/10% FBS. Subcellular fractionation was performed by three rounds of freeze-thaw in CHAPS lysis buffer. Caspase activity was assayed according to the manufacturer's instructions (BioVision). Otherwise, our studies used standard cellular and molecular biology techniques. RESULTS First, we demonstrate an increase in activity of caspases 10, 8, 9, and 3, but not caspase 1, in response to KPT-330/CFZ treatment. Inhibition of caspase 10 activity prevented activation of caspases 8, 9 and 3, abrogated cleavage of apoptotic substrates, including PARP and NF-κB, and significantly protected MM cells from the cytotoxic effects of SINE/PI treatment. Caspases 8 and 10 are orthologs; caspase 10 is not present in mice and is not well-characterized. In response to PI, caspase 8 is recruited to autophagic membranes via interaction with Sequestosome1 (p62) and LC3, key autophagy components whose membrane localization is enriched upon PI treatment, creating an intracellular death-inducing signaling complex. Therefore, we hypothesized that, given the homology and functional overlap between caspases 8 and 10, the same could be possible of caspase 10. To test this, we performed subcellular fractionation to separate soluble cytoplasmic proteins from detergent-insoluble, membrane-embedded proteins and interrogated the relationship between caspase 10 and p62. In untreated cells we were struck by the presence of active fragments of caspases 10, 8, and 9, but not 3, in the insoluble fractions; full-length pro-caspases were found mostly in the soluble extracts. Selinexor/CFZ enhanced activation of all caspases and nearly the entire population of active caspases was found in the detergent-insoluble fractions. Total p62 levels were prominently induced by SINE/PI treatment and two cleavage fragments that correspond to the size of previously-identified in vitro caspase-cleaved fragments were found exclusively in the insoluble fraction. These data suggested that relocalization of caspase fragments to an intracellular membrane harnesses caspase activity. Next, we used indirect immunofluorescence microscopy to assess the localization of caspases 10 and 8 and p62. Untreated cells showed diffuse staining, whereas selinexor/CFZ-treated cells had punctate staining and co-localization of caspases 10 and 8 with p62. Finally, in untreated cell lysates, GST-p62 pulled down endogenous LC3 and pro-caspase 10, but not its active fragments. Pro-caspase 10/GST-p62 association was dramatically reduced when using lysates from SINE/PI-treated cells, suggesting a priming effect of their association. CONCLUSIONS Our results are the first to demonstrate an intracellular mechanism of caspase 10 activation and suggest a model of synergy wherein selinexor/CFZ increase autophagic membranes embedded with p62 and LC3 that associate with pro-caspase 10 promoting its activation, likely by induced proximity, cleavage of other caspases and targets, and subsequent apoptosis (Figure). The nature of the novel intracellular membrane-embedded aggregate of active caspases requires further investigation. Figure 1 Figure 1. Disclosures McCauley: Karyopharm Therapeutics Inc.: Employment, Equity Ownership, Patents & Royalties. Shacham:Karyopharm Therapeutics: Employment. Kauffman:Karyopharm Therapeutics: Employment. Jakubowiak:Bristol Myers-Squib: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Janssen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Millennium: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Onyx: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; SkylineDx: Honoraria, Membership on an entity's Board of Directors or advisory committees.
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42

Rosebeck, Shaun, Mattina Alonge, Jagoda Jasielec, Anoop Mayampurath, Samuel L. Volchenboum, Sharon Shacham, Michael Kauffman, and Andrzej Jakubowiak. "Gene Expression and Transcription Factor (TF) Activation Profiling Identifies Suppression of Multiple Myeloma (MM) Cell Survival and Chemoresistance Pathways By Inhibition of XPO1/CRM1-Dependent Nuclear Export with Selinexor." Blood 124, no. 21 (December 6, 2014): 3444. http://dx.doi.org/10.1182/blood.v124.21.3444.3444.

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Abstract INTRODUCTION Despite improved response rates following the use of novel therapeutics, including proteasome inhibitors (PI) and immunomodulatory drugs, the majority of MM patients develop chemoresistance and relapse. Thus, it is essential to identify novel drugs that overcome resistance and promote remission. Our previous work detailed the synergistic activity of combined treatment with selective inhibitor of nuclear export (SINE) selinexor and PI carfilzomib (CFZ) in MM (Rosebeck et al, Blood 2013:122(21):279). In this study, we sought to characterize the underlying mechanism of selinexor, a novel drug being tested in multiple phase I/II clinical trials of advanced-stage cancers. METHODS Plasma cells (PC) were purified from MM patient bone marrow (BM) aspirates using EasySep (STEMCELL Tech). RPMI 8226, 8226/Dox40, and MM1S cells were cultured in RPMI1640/10% FBS. RNA was isolated with RNeasy minicolumns (Qiagen) from control or MM1S cells treated for 6 hrs with selinexor. Gene expression profiling was done on Illumina HumanHT12 microarray and InfernoRDN. Differentially expressed genes were input into Ingenuity Pathway Analysis software (Qiagen). Fisher’s exact test was used to calculate p-values for significant pathway enrichment. TF profiling plate array was from Signosis. RESULTS Selinexor treatment inhibited key MM pathway regulators including transforming growth factor beta 1 (TGFB1; p=1.65E-14), which is involved in paracrine BM signaling and bone formation, and the epidermal growth factor (EGF) receptor HER2 (p=4.84E-08), which deregulates EGF signaling and promotes survival. SINE also affected integrin-associated signaling (p=2.42E-03), which controls MM/BM stromal cell adhesion and contributes to chemoresistance. We profiled SINE-dependent changes in TF activation and found increased DNA binding of cAMP response element-binding protein (CREB), which represses IL-6 production, an essential MM cell survival cytokine, and retinoid X receptor (RXR), which is associated with MM cell death. We also found impaired DNA binding of heat shock factors (HSF), which sensitizes MM cells to PI, Kruppel-like factor 4 (KLF4) and multidrug resistance (MDR) promoter-enhancing factors 1 and 2 (MEF-1/2), which are associated with chemoresistance in MM, nuclear respiratory factor 1 (NRF-1), which mediates a recovery pathway to compensate for reduced proteasome function, and paxillin 2 (Pax2), a transcriptional repressor of p53 and enhancer of Wilms tumor protein (WT1). In addition, TF associated with poor prognosis MM, including the pre-B cell homeobox (PBX) oncogene, soluble mucin 1 (SMUC), and WT1, were inhibited. Next, we tested the ability of selinexor to overcome drug resistance in MM cells. 8226/Dox40 are insensitive to the effects of CFZ via upregulation of p-glycoprotein, however selinexor effectively killed these cells. Importantly, we demonstrate efficacy of SINE on PC from patients refractory to and/or relapsing (R/R) on PI-containing regimens. Additionally, we will present preliminary responses from CFZ-refractory patients enrolled in our newly-opened multi-site phase I clinical trial conducted in the MM Research Consortium combining selinexor and CFZ with dexamethasone in R/R MM (NCT02199665). CONCLUSIONS Our results suggest selinexor-dependent inhibition of pathways that promote intrinsic MM cell survival and contribute to chemoresistance in the BM milieu, which may be mediated by suppression of essential growth factors and genes involved in MM cell/BM stroma adhesion. We also found inhibition of TF that may influence MDR/PI resistance either directly (KLF4, MEF-1/2) or indirectly (HSF, NRF-1). Finally, we demonstrate the ability of SINE to overcome MDR in MM cells and PC from patients with R/R disease. Our studies provide evidence of the pleiotropic effects of SINE and underscore the potential of selinexor to be an effective therapeutic for advanced-stage cancers, including MM. Disclosures Shacham: Karyopharm Therapeutics Inc.: Employment, Equity Ownership, Membership on an entity's Board of Directors or advisory committees, Patents & Royalties. Kauffman:Karyopharm Therapeutics: Employment. Jakubowiak:Bristol Myers-Squib: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Janssen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Millennium: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Onyx: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; SkylineDx: Honoraria, Membership on an entity's Board of Directors or advisory committees.
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43

Jakubowiak, Andrzej, Jagoda Jasielec, Cara A. Rosenbaum, Craig E. Cole, Ajai Chari, Jennifer Nam, Erica Severson, et al. "Final Results of Phase 1 MMRC Trial of Selinexor, Carfilzomib, and Dexamethasone in Relapsed/Refractory Multiple Myeloma (RRMM)." Blood 128, no. 22 (December 2, 2016): 973. http://dx.doi.org/10.1182/blood.v128.22.973.973.

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Abstract Background There are an increasing number of multiple myeloma (MM) patients (pts) refractory to currently available drugs, including the proteasome inhibitors bortezomib and carfilzomib (CFZ), necessitating development of novel therapeutics. Pre-clinical evaluation of selinexor (SEL), an orally available Selective Inhibitor of Nuclear Export (SINE) compound, demonstrated synergistic myeloma cell death with CFZ and mechanistic rationale for overcoming resistance to CFZ (Rosebeck et al., 2016), providing support for this phase 1 trial. Aims The primary objectives were to assess the maximum tolerated dose (MTD) of a SEL, CFZ and dexamethasone (DEX) combination and to obtain preliminary efficacy data for this novel regimen in RRMM pts. Methods Pts with RRMM who progressed after at least two prior treatment regimens of myeloma therapy were eligible for enrollment. Dose escalation followed the 3+3 design with pts receiving 30 mg/m2 - 40 mg/m2 SEL PO on days (D) 1, 3, 8, 10, 15, 17; 20 mg/m2 - 56 mg/m2 CFZ IV on D 1, 2, 8, 9, 15, 16, and DEX PO (20mg cycles 1-4/ 10mg cycles 5+) in 28-day cycles (C) in up to 5 dose levels. An expansion cohort has enrolled additional pts to a total of 12 CFZ-refractory pts treated at the recommended Phase 2 dose (RP2D). Dose Limiting Toxicities (DLTs) were evaluated through C2D1. Responses were assessed by IMWG criteria plus near complete response (nCR). Results As of July 1st, 2016, the study has completed dose escalation and enrolled a total of 18 pts; 5 at dose level 1 (30 mg/m2 SEL, 20/27 mg/m2 CFZ, 20/10 mg DEX), 3 at dose level 2a (30 mg/m2 SEL, 20/36 mg/m2 CFZ, 20/10 mg DEX), and a total of 10 (7 in dose escalation, 3 in cohort expansion) at dose level 2b (60mg flat dose SEL, 20/27 mg/m2 CFZ and 20/10 DEX). Pts age ranged between 55 to 74 years with a median of 63.5 years; and had a median of 4 prior treatment regimens (range 2-10). Sixteen pts were evaluable for response, all refractory to their last line of therapy. All 16 response evaluable pts were refractory to CFZ, of which 11 were refractory to CFZ combinations as their last line of therapy, including 8 to a KPd combination of CFZ, pomalidomide, and DEX. Fifteen pts were evaluable for DLT and 3 of 18 pts required replacement for DLT evaluation (1 had DEX reduced not due to DLT; 2 did not receive all scheduled C1 doses). In the dose escalation phase, there was one DLT of cardiac amyloidosis (CA) in a pt with history of prior congestive heart failure and CA at baseline. While the maximum tolerated dose (MTD) has not been reached, the RP2D was identified at dose level 2b based on tolerability. Grade 3/4 adverse events (AEs) included: thrombocytopenia (67%), neutropenia (33%), anemia (17%), fatigue (17%), and infections (11%). The most common all grade AEs included: gastrointestinal disorders (78%), thrombocytopenia (73%), fatigue (72%), anemia (47%), dyspnea (33%), and elevated liver and pancreatic enzymes (28%). There were 2 (11%) serious AEs, 1 upper respiratory infection and 1 lower gastrointestinal bleeding. All adverse events were manageable with concomitant medications. Response rates for all evaluable pts were 75% ≥MR (12 of 16), 63% ≥PR, and 25% ≥VGPR. Response rates in CFZ-refractory pts at last line of treatment were 73%, 64%, and 18% respectively. Responses occurred rapidly; after C1 with 75% ≥MR. As of the data cutoff date, 15 pts progressed (between 1 and 14 months on study) and 3 pts remained on treatment (1 - 4 months). Conclusions The combination of SEL, CFZ, and DEX demonstrates encouraging activity and safety in heavily pretreated, mostly CFZ-refractory myeloma. In addition, with 64% PR or better for pts progressing on CFZ, these results provide early clinical evidence that selinexor has the ability to overcome CFZ resistance, warranting further investigation of this regimen in RRMM. Disclosures Jakubowiak: Sanofi: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Karyopharm: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; SkylineDx: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Amgen Inc.: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; BMS: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees. Rosenbaum:Celgene: Speakers Bureau. Chari:Novartis: Consultancy, Research Funding; Amgen Inc.: Honoraria, Research Funding; Pharmacyclics: Research Funding; Array Biopharma: Consultancy, Research Funding; Janssen: Consultancy, Research Funding; Takeda: Consultancy, Research Funding; Celgene: Consultancy, Research Funding. Zonder:Pharmacyclics: Other: DSMC membership; Celgene: Consultancy, Honoraria, Research Funding; Seattle Genetics: Consultancy, Honoraria; Bristol Myers Squibb: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Prothena: Consultancy, Honoraria.
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44

Vigrass, L. W., and R. G. Vigrass. "Horizontal Wells In The Rosebank Alida Beds Pool, Saskatchewan." Journal of Canadian Petroleum Technology 35, no. 03 (March 1, 1996). http://dx.doi.org/10.2118/96-03-06.

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45

Sætre, C., H. Hellevang, C. Dennehy, and H. Dypvik. "Reactive transport modelling of an intra-basalt sandstone reservoir, Rosebank, UK." Scientific Reports 11, no. 1 (March 25, 2021). http://dx.doi.org/10.1038/s41598-021-86421-w.

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AbstractThe Rosebank field, located in the Faroe-Shetland Basin, contains producible hydrocarbons in intra-basaltic siliciclastic reservoirs. The volcanic-reservoir interface is poorly studied and the geochemical system, as a function of distance from the basalt, is largely unknown. The current paper applies a geochemical model coupling mineral dissolution and precipitation with element diffusion to investigate the geochemical system in time and space from the basalt-sandstone interface. Earlier studies indicate few negative effects on reservoir properties despite the proximity to a reactive volcanic lithology. The causes of this minimal impact have not been studied. The numerical simulations in this study expand on the knowledge demonstrating that precipitation of authigenic phases at the basalt-sandstone interface buffer the formation water solution for key elements, which hamper the transport of solutes and subsequent precipitation of secondary minerals within the reservoir. Saturation index values over the simulated period indicate that precipitation of authigenic phases should not extend beyond the basalt-sandstone interface. This shows that diffusion alone is not enough to reduce the reservoir quality due to increased precipitation of secondary phases. The basalt dissolution rate varies according to the silica concentration. The combined effects on silica concentration by diffusional fluxes, mineral precipitation and dissolution, control the basalt dissolution rate, and there are no differences in the results between high and low basalt reactive surface area.
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46

Millett, John M., Dougal A. Jerram, Ben Manton, Sverre Planke, Peter Ablard, Dirk Wallis, Malcolm J. Hole, Harry Brandsen, David W. Jolley, and Cliona Dennehy. "The Rosebank Field, NE Atlantic: Volcanic characterisation of an inter‐lava hydrocarbon discovery." Basin Research, August 20, 2021. http://dx.doi.org/10.1111/bre.12585.

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47

"The Stryker Dacron Ligament in Chronic Anterior Cruciate Ligament Tears Cliue A. Noble, FRC-Rosebank, South Africa." American Journal of Sports Medicine 17, no. 5 (September 1989): 723. http://dx.doi.org/10.1177/036354658901700587.

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48

Halligey, Alexandra. "‘Dark’ cities: The role of interdisciplinary work in learning and supporting marginal city spaces." Urban Studies, June 27, 2020, 004209802093099. http://dx.doi.org/10.1177/0042098020930995.

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This article considers Harold Johnson’s (Hariwe) 2014–2016 research project on ‘Dark City’, an informal vertical settlement in inner-city Johannesburg, as offering a productive arts-orientated, interdisciplinary study of and proposal for planning and design interventions in informally occupied urban spaces. Hariwe used his architectural skills to ‘reverse design’ the building according to its daily use by residents. Collaborators Jono Wood and Dirk Chalmers followed a similar research process with ‘Dark City’, using their own modalities of photography and film. The three exhibited at the Circa Gallery in Rosebank, Johannesburg in 2016, constructing an immersive simulation of the ‘Dark City’ environment to set their drawings, photographs and films within. This article uses the lenses of performance and performativity to argue for the research and creative processes of The ‘Dark City’ project as slowing down time, layering spaces across time and location and creating a sensual, immersive experience. These three effects serve to bring into view and experience the circumstances of ‘Dark City’, the kinds of inequalities at work in Johannesburg that produce such spaces and to propose design responses for spatial justice.
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Layfield, Lucinda K., Nick Schofield, David W. Jolley, Simon P. Holford, Tudor-Remus Volintir, Ben A. Kilhams, David K. Muirhead, and Helen Cromie. "New Insights into the Structure, Geology and Hydrocarbon Prospectivity along the Central-Northern Corona Ridge, Faroe-Shetland Basin." Petroleum Geoscience, July 18, 2022, petgeo2021–090. http://dx.doi.org/10.1144/petgeo2021-090.

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The Faroe-Shetland Basin (FSB) is one of the only significant exploration frontiers remaining on the UK Continental Shelf. Over half of the basin's discovered reserves and resources lie along two intra-basinal highs, the Corona Ridge and Rona Ridge. In contrast to the Rona Ridge, the central-northern Corona Ridge has received much less attention. To reveal new insights into the geology, structural configuration, and hydrocarbon prospectivity of the central-northern Corona Ridge we analyse 3D seismic data and data from exploration wells 213/23-1 (Eriboll), 214/21a-2 (South Uist) and 213/25c-1V (North Uist). This study extends the Colsay T40-T45 sub- and intra-basaltic play concept from the Rosebank Field NE along the Corona Ridge, at least into 213/23-1. Analysis also suggests that no Triassic strata are present within 213/23-1, challenging the previous understanding of Triassic distribution within the central FSB. Our findings show that the central-northern Corona Ridge is structurally complex, comprised of a series of discrete basement bounding faults, down-flank fault terraces and faults which are oblique to the dominant NE-SW-striking structural fabrics of the FSB.
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"Epilobium angustifolium (rosebay willowherb)." CABI Compendium CABI Compendium (January 7, 2022). http://dx.doi.org/10.1079/cabicompendium.21447.

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