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1

Ayres, Samuel. "Rosacea and Rosacea-like Demodicldosis." International Journal of Dermatology 26, no. 3 (April 1987): 198–99. http://dx.doi.org/10.1111/j.1365-4362.1987.tb00894.x.

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2

Rallis, Efstathios, and Chrysovalantis Korfitis. "Isotretinoin for the Treatment of Granulomatous Rosacea: Case Report and Review of the Literature." Journal of Cutaneous Medicine and Surgery 16, no. 6 (November 2012): 438–41. http://dx.doi.org/10.1177/120347541201600615.

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Background: Granulomatous rosacea is considered a clinical variant of rosacea and is characterized by hard yellow, brown, red or flesh-colored cutaneous papules or nodules that may be severe and may lead to scarring. The lesions typically appear on the cheeks and periorificial lesions; they are monomorphic in each patient and sit on relatively normal-appearing skin. The diagnosis should be established by excluding other granulomatous disorders and rosacea-like eruptions such as sarcoidosis, tuberculosis, and lupus miliaris disseminatus faciei. The clinical course is chronic and unpredictable, and management can be very difficult. Case Report: We report the case of a 28-year-old female with granulomatous rosacea who responded successfully to oral isotretinoin. No recurrence was noticed 6 months after the completion of treatment. Renseignements de base: La rosacée granulomateuse est considérée comme une variante clinique de la rosacée et est caractérisée par la présence de papules cutanées jaunes, brunes, ou fleshed-colored rouges dures ou par de nodules qui peuvent être graves et qui peuvent causer des cicatrices. Les lésions sont généralement localisées aux joues et sur les lésions péri-orificielles; elles sont monomorphes chez chaque patient individuel et elles siègent sur une peau d'apparence relativement normale. Le diagnostic doit être établi en excluant les autres troubles granulomateux et les éruptions rosacéiformes comme la sarcoïdose, la tuberculose, et la tuberculide papulonodulaire. L'évolution clinique est chronique et imprévisible, et la gestion peut être très difficile. Rapport de cas: Nous rapportons le cas d'une femme âgée de 28 ans présentant une rosacée granulomateuse qui a été traité avec succès avec l'isotrétinoïne administrée par voie orale. Aucune récidive n'a été observée 6 mois après la fin du traitement.
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3

Searle, Tamara, Firas Al-Niaimi, and Faisal R. Ali. "Rosacea." British Journal of Hospital Medicine 82, no. 2 (February 2, 2021): 1–8. http://dx.doi.org/10.12968/hmed.2020.0417.

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Rosacea is a common cutaneous condition affecting predominantly the face. It is historically characterised into four subtypes: erythematotelangiectatic, papulopustular, phymatous and ocular rosacea. This article describes the pathophysiology, clinical features and current treatment options for rosacea, and discusses updated diagnostic criteria. General guidance is required on the need to avoid possible triggers including dietary and environmental triggers. The strongest evidence supports the use of 0.75% metronidazole, topical azelaic acid or topical ivermectin for inflammatory rosacea. Erythema should be treated with brimonidine tartrate gel, oral medication such as beta blockers or vascular laser and light-based therapy. Oral doxycycline 40 mg modified release can be used as monotherapy or in combination with other treatments for recalcitrant disease. Further understanding of the pathogenesis of rosacea could allow identification and targeted avoidance of triggers and the development of new treatment modalities.
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4

Pánková, Růžena. "Rosacea." Dermatologie pro praxi 11, no. 1 (April 1, 2017): 6–11. http://dx.doi.org/10.36290/der.2017.002.

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5

Gibson, Lawrence E. "Rosacea." Mayo Clinic Proceedings 79, no. 9 (September 2004): 1192. http://dx.doi.org/10.4065/79.9.1192.

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6

Elsey, Alison. "Rosacea." InnovAiT: Education and inspiration for general practice 6, no. 7 (July 2013): 442–46. http://dx.doi.org/10.1177/1755738012467183.

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7

Mishra, Apurva, and Shanu Mishra. "Rosacea." InnovAiT: Education and inspiration for general practice 12, no. 5 (March 15, 2019): 271–75. http://dx.doi.org/10.1177/1755738018810047.

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Rosacea is a common, chronic skin disease that affects the facial pilo-sebaceous glands. It is characterised by erythema, flushing and sometimes papules. It typically affects the convex surfaces of the face, most commonly the forehead, cheeks, chin and nose. Rosacea predominantly affects the Caucasian population, with prevalence being higher in northern Europe than southern Europe. It is three times more common in females and peaks between 30 and 60 years of age. Rosacea can usually be well managed with topical or oral treatments in primary care, although some forms of rosacea or treatment-resistant cases may need specialist input.
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8

Knox, C. Michele, and Gilbert Smolin. "Rosacea." International Ophthalmology Clinics 37, no. 2 (1997): 29–40. http://dx.doi.org/10.1097/00004397-199703720-00004.

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9

CHALMERS, DEBRA A. "Rosacea." Nurse Practitioner 22, no. 10 (October 1997): 18???34. http://dx.doi.org/10.1097/00006205-199710000-00005.

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10

Gauwerky, Katharina, Winfried Klövekorn, Hans Christian Korting, Percy Lehmann, Eva-Maria Meigel, Dieter Reinel, Thomas Ruzicka, Martin Schaller, Helmut Schöfer, and Julia Tietze. "Rosacea." Journal der Deutschen Dermatologischen Gesellschaft 7, no. 11 (November 2009): 996–1003. http://dx.doi.org/10.1111/j.1610-0387.2009.07119.x.

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11

Powell, Frank C. "Rosacea." New England Journal of Medicine 352, no. 8 (February 24, 2005): 793–803. http://dx.doi.org/10.1056/nejmcp042829.

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12

van Zuuren, Esther J. "Rosacea." New England Journal of Medicine 377, no. 18 (November 2, 2017): 1754–64. http://dx.doi.org/10.1056/nejmcp1506630.

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13

Fuller, Dianne, and Suzanne Martin. "Rosacea." Journal of Midwifery & Women's Health 57, no. 4 (June 21, 2012): 403–9. http://dx.doi.org/10.1111/j.1542-2011.2011.00156.x.

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14

Rebora, Alfredo. "Rosacea." Journal of Investigative Dermatology 88, s3 (March 1987): 56s—60s. http://dx.doi.org/10.1111/1523-1747.ep12468949.

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15

SCEVOLA, SILVIA, GIOVANNI NICOLETTI, and ANGELA FAGA. "Rosacea." Dermatologic Surgery 32, no. 1 (January 2006): 167–68. http://dx.doi.org/10.1097/00042728-200601000-00036.

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16

Logan, Richard A. "Rosacea." Medicine 33, no. 1 (January 2005): 48–49. http://dx.doi.org/10.1383/medc.33.1.48.58329.

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17

Maher, Helen K. "Rosacea." AAOHN Journal 55, no. 12 (December 2007): 520. http://dx.doi.org/10.1177/216507990705501205.

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18

Schmid-Ott, G., M. Stephan, and T. Werfel. "Rosacea." Dermatology and Psychosomatics / Dermatologie und Psychosomatik 4, no. 1 (2003): 44–45. http://dx.doi.org/10.1159/000070536.

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19

Gibson, Lawrence E. "Rosacea." Mayo Clinic Proceedings 79, no. 9 (September 2004): 1192. http://dx.doi.org/10.1016/s0025-6196(11)62604-9.

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20

Feldman, Steven R., Leah A. Cardwell, and Sarah L. Taylor. "Rosacea." Dermatologic Clinics 36, no. 2 (April 2018): i. http://dx.doi.org/10.1016/s0733-8635(18)30003-2.

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21

Wilkin, Jonathan K. "Rosacea." International Journal of Dermatology 24, no. 1 (January 1985): 670–71. http://dx.doi.org/10.1111/j.1365-4362.1985.tb05616.x.

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22

Wilkin, Jonathan K. "Rosacea." International Journal of Dermatology 24, no. 10 (December 1985): 670–71. http://dx.doi.org/10.1111/j.1365-4362.1985.tb05723.x.

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23

Webster, Guy F. "Rosacea." Medical Clinics of North America 93, no. 6 (November 2009): 1183–94. http://dx.doi.org/10.1016/j.mcna.2009.08.007.

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24

Barco, D., and A. Alomar. "Rosacea." Actas Dermo-Sifiliográficas (English Edition) 99, no. 4 (2008): 244–56. http://dx.doi.org/10.1016/s1578-2190(08)70247-6.

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25

Zuber, Thomas J. "ROSACEA." Primary Care: Clinics in Office Practice 27, no. 2 (June 2000): 309–18. http://dx.doi.org/10.1016/s0095-4543(05)70197-4.

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26

Chauhan, Nitin, and David A. F. Ellis. "Rosacea." Facial Plastic Surgery Clinics of North America 21, no. 1 (February 2013): 127–36. http://dx.doi.org/10.1016/j.fsc.2012.11.004.

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27

Two, Aimee M., Wiggin Wu, Richard L. Gallo, and Tissa R. Hata. "Rosacea." Journal of the American Academy of Dermatology 72, no. 5 (May 2015): 761–70. http://dx.doi.org/10.1016/j.jaad.2014.08.027.

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28

Two, Aimee M., Wiggin Wu, Richard L. Gallo, and Tissa R. Hata. "Rosacea." Journal of the American Academy of Dermatology 72, no. 5 (May 2015): 749–58. http://dx.doi.org/10.1016/j.jaad.2014.08.028.

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29

Napierkowski, Daria B. "Rosacea." Nurse Practitioner 41, no. 4 (April 2016): 8–13. http://dx.doi.org/10.1097/01.npr.0000470359.23708.33.

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30

Rebora, Alfredo. "Rosacea." Journal of Investigative Dermatology 88, no. 3 (March 1987): 56–60. http://dx.doi.org/10.1038/jid.1987.11.

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31

Scheinfeld, Noah S. "Rosacea." SKINmed 5, no. 4 (July 2006): 191–94. http://dx.doi.org/10.1111/j.1540-9740.2006.05017.x.

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32

Wilkin, Jonathan K. "Rosacea." Archives of Dermatology 130, no. 3 (March 1, 1994): 359. http://dx.doi.org/10.1001/archderm.1994.01690030091015.

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33

Tackett-Fletcher, Wynetta, and Kay Roberts. "Rosacea." Geriatric Nursing 20, no. 1 (January 1999): 44–47. http://dx.doi.org/10.1016/s0197-4572(99)70062-5.

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34

Danby, F. W. "Rosacea, acne rosacea, and actinic telangiectasia." Journal of the American Academy of Dermatology 52, no. 3 (March 2005): 539–40. http://dx.doi.org/10.1016/j.jaad.2004.08.043.

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35

Kansal, Naveen Kumar, Anupam Singh, and Barun Kumar. "Ophthalmological involvement in rosacea: Ocular rosacea." Himalayan Journal of Ophthalmology 18, no. 2 (July 2024): 44–46. http://dx.doi.org/10.4103/hjo.hjo_16_24.

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Abstract Rosacea is a common, chronic disorder that can present with a variety of cutaneous or ocular manifestations. Cutaneous involvement primarily affects the central face, with findings, such as persistent centrofacial redness, papulopustules, flushing, telangiectasia, and phymatous skin changes (e.g., rhinophyma). Ocular involvement may manifest with lid margin telangiectases, conjunctival injection, ocular irritation, or other signs and symptoms. In this review, we focus on the ophthalmological manifestations of rosacea and its management.
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36

Elkin, Peter, Sarah Mullin, Sanjay Sethi, Shyamashree Sinha, and Animesh Sinha. "2240." Journal of Clinical and Translational Science 1, S1 (September 2017): 13. http://dx.doi.org/10.1017/cts.2017.62.

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OBJECTIVES/SPECIFIC AIMS: To create a new semantically correct high-throughput phenotyping (HTP) platform. To demonstrate the utility of the HTP platform for observational research and can allow clinical investigators to perform studies in 5 minutes. To demonstrate the improved accuracy of observational research using this platform when compared with traditional observational research methods. To demonstrate that patients who have Roseacea are at increased risk of having obstructive sleep apnea (OSA). METHODS/STUDY POPULATION: This population is a set of 212,343 patients in the outpatient setting cared for in the Buffalo area over a 6-year period. All records for these patients were included in the study. Structured data was imported into an OMOP (OHDSI) database and all of the notes and reports were parsed by our HTP system which produces SNOMED CT codes. Each code is designated as a positive, negative or uncertain assertion and compositional expressions are automatically generated. We store the codified data 750,000,000 codes in Berkley DB, a NOSQL database, and we keep the compositional graphs in both Neo4J and in GraphDB (a triple store). Labs are coded in LOINC and drugs using RxNorm. We have developed a Web interface in .Net named BMI Search, which allows real-time query by subject matter experts. We analyzed the accuracy of structured Versus unstructured data by identifiying NVAF cases with ICD9 codes and then looked for any additional cases based on the SNOMED CT encodings of the clinical record. This was validated by 2 clinical human review of a set of 300 randomly selected cases. Separately we ran a study to determine the relative risk of OSA with and without Rosacea using the data set described above. We compared the rates using a Pearson χ2 test. RESULTS/ANTICIPATED RESULTS: We are able to parse 7,000,000 records in an hour and a half on 1 node with 4 CPUs. This yielded 750,000,000 SNOMED CT codes. The HTP data set yielded 1849 cases using ICD9 codes and another 873 using the HTP-NLU data, leading to a final data set of 2722 cases from our population of 212,343 patients. In total, 580 patients had Rosacea;5443 patients had OSA without Rosacea and 51 patients had OSA with Rosacea. Patients with Rosaca had an 8.8% risk of OSA whereas patients without Rosacia only had a 2.6% risk of OSA. This was highly statistically significant with a p<0.0001 (Pearson χ2 test). The number needed to test was only 12. DISCUSSION/SIGNIFICANCE OF IMPACT: HTP can change how we do observational research and can lead to more accurate and more prolific investigation. This rapid turn around is part of what is necessary for both precision medicine and to create a learning health system. Patients with Rosacea are at increased risk of and should be screened for OSA.
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37

Coutinho, Jessica Castiel, Danielle Cristine Westphal, Laís Cruz Lobato, Antônio Pedro Mendes Schettini, and Mônica Santos. "Rosacea fulminans: unusual clinical presentation of rosacea." Anais Brasileiros de Dermatologia 91, no. 5 suppl 1 (October 2016): 151–53. http://dx.doi.org/10.1590/abd1806-4841.20164943.

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38

Cribier, B. "Pathophysiology of rosacea: redness, telangiectasia, and rosacea." Annales de Dermatologie et de Vénéréologie 138 (November 2011): S184—S191. http://dx.doi.org/10.1016/s0151-9638(11)70088-6.

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39

Chae, Kyunghee, Suyeon Kim, Sukil Kim, and Yu Ri Woo. "Increased Risk of Glaucoma in Patients with Rosacea: A Nationwide Population-Based Cohort Study." Journal of Clinical Medicine 12, no. 11 (May 30, 2023): 3759. http://dx.doi.org/10.3390/jcm12113759.

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Rosacea is a chronic inflammatory skin disorder associated with various ocular manifestations. However, little is known about the association between rosacea and glaucoma. This study aimed to determine the risk of glaucoma in patients with rosacea. This nationwide population-based retrospective cohort study enrolled 1056 individuals with rosacea and 10,440 age- and sex-matched controls without rosacea from the Korean National Health Insurance System (NHIS) database from 2002 to 2015. The incidence rate of glaucoma was 1215.4 per 100,000 person-years (PYs) in patients with rosacea and 741.3 per 100,000 PYs in patients without rosacea. A significantly higher cumulative incidence probability of glaucoma was observed in patients with rosacea than in non-rosacea controls (p = 0.0004). Rosacea was associated with an increased risk of developing glaucoma (adjusted hazard ratio [aHR], 1.659; 95% confidence interval [CI], 1.245–2.211) compared to those without rosacea. In subgroup analysis, increased risk of glaucoma was observed in patients with rosacea younger than 50 years (aHR, 1.943; 95% CI, 1.305–2.893), females (aHR, 1.871; 95% CI, 1.324–2.644), and patients with hypertension (aHR, 1.561; 95% CI, 1.037–2.351) compared to those without rosacea. Rosacea is associated with an increased risk of developing glaucoma. Proper screening for glaucoma should be conducted in rosacea patients younger than 50 years, females, and patients with hypertension to better control the disease and prevent vision loss from glaucoma.
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40

Moustafa, Farah, Dennis Hopkinson, Karen E. Huang, and Steve Feldman. "Prevalence of Rosacea in Community Settings." Journal of Cutaneous Medicine and Surgery 19, no. 2 (March 2015): 149–52. http://dx.doi.org/10.2310/7750.2014.14087.

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Background The prevalence of rosacea is poorly characterized. Because selection bias may affect prevalence estimates, there is a need to characterize the prevalence of rosacea outside the clinic setting. Objective To assess the prevalence of rosacea in community settings. Methods A clinical research fellow and a medical student stood in public places (a mall, the Department of Motor Vehicles, a grocery store) and examined consecutive individuals who passed by ≤ 2 yards away. They tallied demographic and descriptive data on the subject and included the subject in one of three categories: clearly rosacea, possible rosacea, and definitely no rosacea. Subanalyses by perceived gender, age, race, and rosacea subtype were also performed. Comparisons between groups were made using the Fisher exact test. Results Considering the prevalence of rosacea among all observed individuals in the community setting, 5.4% (95% CI 3.6-7.8) of individuals had “possible” rosacea and 6% (95% CI 4.1-8.5) of individuals had “definite” rosacea. Older, white individuals with fairer skin types (Fitzpatrick skin types I, II, and III) were more likely to have rosacea. There was no gender predisposition. Limitations Distance from subjects made it difficult to assess patients with mild rosacea or a few telangiectasias, as well as ocular rosacea. The study could not assess those individuals who were too embarrassed by their rosacea to be in the public settings observed. Additionally, some subjects may have applied significant makeup in an effort to conceal their rosacea, making assessment difficult. Conclusions Based on direct observation of individuals in community settings, rosacea is more common than previously reported in the United States.
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41

Gawęda, Agnieszka, Rafał Babiak, Karolina Bajak, Paulina Czuchryta, Anastazja Domańska, Agata Grabek, Julia Rutkowska, Żaneta Rzęsa-Tokarczyk, Klaudia Skorek, and Agnieszka Urbańczyk. "Rosacea – a modern view of diagnostics and treatment." Journal of Education, Health and Sport 46, no. 1 (August 26, 2023): 258–72. http://dx.doi.org/10.12775/jehs.2023.46.01.018.

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Introduction: Rosacea is a chronic inflammatory skin disease affecting central region of the face. Main symptoms consist of erythema, flushing, telangiectasia, phymatous changes and inflammatory papules and pustules. It can also affect eyes, causing blepharitis, conjunctivitis, keratitis or lid margin telangiectasia. Rosacea can negatively affect the quality of life, causing low self-esteem, avoidance of social interactions and mental health issues such as anxiety and depression. There are two classifications of rosacea, one from 2002 focusing on subtypes, and new phenotype-based classification. Phenotype-based approach allows individual management of each patient instead of categorizing by predefined subtype. Due to increased frequency of Demodex infestation in patients with rosacea, diagnosis and treatment of demodicosis can be helpful in management of rosacea. General treatment of rosacea consists of combination of oral and topical therapies, choosing adequate skincare cosmetics, laser therapies and avoidance of identified trigger factors specific for the patient. The aim of the study: This study aims to gather current knowledge about classification, diagnostics, skincare and treatment of rosacea. Materials and methods: This review was based on available data collected in the PubMed database, using the keywords: ‘rosacea’, ‘ocular rosacea’, ‘rosacea treatment’. Conclusions: The treatment of rosacea requires selection of appropriate treatment depending on symptoms specific for the patient. Because of increased Demodex infestation present in some of the patients with rosacea, eradication can mitigate rosacea symptoms. Identification and avoidance of trigger factors and assortment of adequate skincare products are also substantial parts of management of rosacea and can alleviate rosacea symptoms.
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42

Yoshizawa, Yusuke. "Rosacea in Adolescents and Young Adults: High Prevalence Concurrent with Acne Vulgaris Treated with Benzoyl Peroxide and/or Adapalene." Journal of Clinical Cases and Reports 6, S15 (November 1, 2023): 265–76. http://dx.doi.org/10.46619/joccr.2023.6-s15-1081.

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BACKGROUND The incidence of rosacea in adolescents and young adults with acne vulgaris has been increasing; however, the underlying factors and clinical symptoms have not been clearly described. AIM To investigate the factors underlying the recent increase in the prevalence of rosacea with acne vulgaris, with a focus on changes in social and medical factors over the past decade. METHODS A case series of rosacea conducted from April 2022 to May 2023. Characteristics and clinical symptoms of rosacea with acne vulgaris in adolescents and young adults were investigated. As a countermeasure against rosacea, two-color (blue and red) light-emitting diodes (LED) were irradiated. RESULTS Of the total 84 patients with rosacea, 34 (40.8%) had rosacea with acne vulgaris. All patients had onset before the age of 30 years, particularly in the teenage years (25 cases). All patients with rosacea and acne vulgaris developed rosacea during benzoyl peroxide and/or adapalene (BPO/adapalene) therapy, with a higher incidence in females than in males. During the study period, 863 patients with acne vulgaris were identified in the author’s clinic, and 34 (3.9%) had rosacea and acne vulgaris. Among the 863 patients with acne vulgaris, 437 (50.6%) were using BPO/adapalene, whereas all (100%) patients with rosacea and acne vulgaris were using BPO/adapalene (p = 0.0083). Among the female patients with acne vulgaris, 265 used BPO/adapalene, and 29 (10.9%) developed rosacea. Contrastingly, 172 males used BPO/adapalene, and 5 (2.9%) developed rosacea, which was a lower rate than that in females (p = 0.0051). CONCLUSION In the present study, all patients with rosacea and acne vulgaris had an age of onset of less than 30 years, and most were teenage females. All patients developed rosacea during BPO/adapalene therapy for acne vulgaris and wore masks for at least 6 hours per day. Rosacea in patients with acne vulgaris may be induced by BPO/adapalene and prolonged mask-wearing. Preventing rosacea development during acne vulgaris treatment is important, especially in female adolescents; mask-wearing should be avoided as much as possible, and additional LED therapy may help prevent rosacea during BPO/adapalene therapy.
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43

Aripova, M. L. "EFFECT OF ANTIHELMINTHIC THERAPY ON THE SKIN PROCESS IN ROSACEA PATIENTS IN COMBINATION WITH OPISTHORCHIASIS." Bulletin of Siberian Medicine 14, no. 1 (February 28, 2015): 12–17. http://dx.doi.org/10.20538/1682-0363-2015-1-12-17.

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The article presents results of examination of 144 patients, including 64 patients with rosacea in combination with chronic opisthorchiasis (group 1) and 80 patients with rosacea without opistorchiasis (group 2). Rosacea patients with concomitant chronic opisthorchosis revealed more severe clinical variants. Mean values of the index scale diagnostic assessment of rosacea is significantly higher than in patients rosacea without helminthiasis, indicating a more severe course. Dissatisfaction with the quality of life in patients with rosacea in combination with chronic opisthorchiasis was significantly higher than in patients with rosaceaonly. Patients with rosacea in combination with chronic opisthorchiasis reveled prevalence of anxiety and depression in scale of HADS. There are also were a comparative analysis of the clinical picture in patients with rosacea anthelmintic therapy and without deworming.
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44

Nevoralová, Zuzana, and Lumír Poch. "Granulomatous rosacea." Dermatologie pro praxi 10, no. 3 (October 1, 2016): 136–40. http://dx.doi.org/10.36290/der.2016.031.

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45

Millikan, Larry. "Recognizing rosacea." Postgraduate Medicine 105, no. 2 (February 1999): 149–58. http://dx.doi.org/10.3810/pgm.1999.02.549.

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46

Koh, HongYi, SeeKet Ng, and WeePing Tan. "Rosacea fulminans." Indian Journal of Dermatology, Venereology, and Leprology 80, no. 3 (2014): 272. http://dx.doi.org/10.4103/0378-6323.132267.

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47

Gallo, Rosella, Francesco Drago, Stefania Paolino, and Aurora Parodi. "Rosacea Treatments." American Journal of Clinical Dermatology 11, no. 5 (October 2010): 299–303. http://dx.doi.org/10.2165/11537020-000000000-00000.

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48

Akpek, Esen Karamursel, Amyna Merchant, Vakur Pinar, and C. Stephen Foster. "OCULAR ROSACEA." Cornea 16, no. 2 (March 1997): 247. http://dx.doi.org/10.1097/00003226-199703000-00034.

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WEBER, PAUL J., and BRENT R. MOODY. "Surgical Rosacea." Dermatologic Surgery 28, no. 4 (April 2002): 329–30. http://dx.doi.org/10.1097/00042728-200204000-00005.

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Generali, Joyce A., and Dennis J. Cada. "Ondansetron: Rosacea." Hospital Pharmacy 47, no. 8 (August 2012): 601–2. http://dx.doi.org/10.1310/hpj4708-601.

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