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Povee, Kate. "The identities and social roles of people with intellectual disabilities: Challenging dominant cultural worldviews, values and mythologies." Thesis, Curtin University, 2014. http://hdl.handle.net/20.500.11937/785.
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The aim of this research was to explore the social construction of intellectual disability and to increase the power of people with intellectual disabilities in the research process. Informed by a contextualist perspective, this research was conducted within a participatory framework. Causal layered analysis was used to deconstruct the data revealing a complex dynamic of worldviews and mythologies which served to dehumanise people with intellectual disabilities and blame them for their own fate (victim blaming).
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LEIPOLDT, Erik, and eleipoldt@upnaway com. "Good life in the balance: a cross-national study of Dutch and Australian disability perspectives on euthanasia and physician-assisted suicide." Edith Cowan University. Education And Arts: School Of, 2003. http://adt.ecu.edu.au/adt-public/adt-ECU2006.0010.html.
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This is a cross-national qualitative study with the purpose of obtaining perspectives held by people with quadriplegia and leading figures in disability movements in the Netherlands and Australia on the issues of euthanasia and physician-assisted suicide (EPAS). A disability voice is not prominent in public debate on EPAS in Australia or the Netherlands, even though people with disabilities are often thought to be vulnerable in relation to EPAS policies. Disability perspectives are potentially valuable in illuminating issues in relation to euthanasia and physician-assisted suicide, because issues of dependence, independence, and individual autonomy play important roles in relation to both EPAS and to living with disability. The study's methodology uses a phenomenological approach and incorporates aspects of heuristics and grounded theory. Its conceptual framework incorporates MacIntyre's (1999) theory of acknowledged dependency and vulnerability; Habermas' (1989) theory of knowledge; and Festinger's (1959) theory of cognitive dissonance. The main sample of twenty people with quadriplegia (the grassroots sample) was interviewed in the Netherlands and in Australia.
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Leipoldt, Erik A. "Good life in the balance: A cross-national study of Dutch and Australian disability perspectives on euthanasia and physician-assisted suicide." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2003. https://ro.ecu.edu.au/theses/116.
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This is a cross-national qualitative study with the purpose of obtaining perspectives held by people with quadriplegia and leading figures in disability movements in the Netherlands and Australia on the issues of euthanasia and physician-assisted suicide (EPAS). A disability voice is not prominent in public debate on EPAS in Australia or the Netherlands, even though people with disabilities are often thought to be vulnerable in relation to EPAS policies. Disability perspectives are potentially valuable in illuminating issues in relation to euthanasia and physician-assisted suicide, because issues of dependence, independence, and individual autonomy play important roles in relation to both EPAS and to living with disability. The study's methodology uses a phenomenological approach and incorporates aspects of heuristics and grounded theory. Its conceptual framework incorporates MacIntyre's (1999) theory of acknowledged dependency and vulnerability; Habermas' (1989) theory of knowledge; and Festinger's (1959) theory of cognitive dissonance. The main sample of twenty people with quadriplegia (the grassroots sample) was interviewed in the Netherlands and in Australia.
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Brdar, Minela, and Sibel Eken. "Skivbolagens roll i musikbranschen : En kvalitativ studie om skivbolagens roll." Thesis, Södertörns högskola, Institutionen för samhällsvetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-33065.
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I takt med den digitala revolutionen har vidden av skivbolagens aktiviteter reducerats. Idag kan individer göra mycket på egen hand som skivbolagen traditionellt sett gjort för sina artister. Rollen som de spelar anses inte vara lika väsentlig i en artists karriär till följd av digitaliseringen. Syftet med denna studie är att skapa förståelse för hur skivbolagens roll ser ut i en digitaliserad och tjänst-dominerad musikbransch. För att kunna besvara syftet har tre semistrukturerade intervjuer utförts, varav en består av två respondenter. Intervjuerna genomfördes med skivbolagen Universal Music, Amuse och ett independent bolag i Stockholm. Studiens empiri visar att aktiviteterna som skivbolag utför är anpassat utefter digitala medier, samt att alla respondenter menar att även om artister i dagsläget kan göra allting själva, är det lättare att lyckas med hjälp av ett skivbolag. Slutsatserna som nåtts är att skivbolagens roll ser ut på det viset att de är artisternas partner, som innebär att de är med dem, och inte för dem. Rollen skivbolagen har i en digitaliserad och tjänst-dominerad musikbransch innebär att de erbjuder artisterna kunskap, kontakter och kapital. Skivbolagens roll har försvagats inom de traditionella aktiviteterna marknadsföring och distribution, och anses istället finnas som stöd och komplement inom dessa aktiviteter. Skivbolagens roll har istället blivit viktigare när det gäller att upptäcka, bygga samt driva artisternas karriärer.With the digital revolution, the scope of record labels’ activities have been reduced. Today, individuals can do a lot on their own, that record labels have traditionally done for their artists. The role they played is not considered as important in the career of an artist today, due to digitization. The aim of this essay is to examine and create insight on how record labels’ role looks like in a digitalized and serice-dominated music industry. To do this, three interviews have been carried out, whereof one interview included two respondents. The interviews were held with the record labels Universal Music, Amuse and an independent label in Stockholm. The results show that the activities that record labels perform are adjusted according to digital media. The results also show that all of the respondents claim that even though artists today can do everything on their own, it is easier to succeed with the help of a record label. The conclusion is that the record labels’ role is that they are partners with their artists, which means that they are with them, and not for them. The role record labels have in a digitalized and service-dominated music industry is that they offer knowledge, connections and capital to their artists. The record labels’ role has been weakened within the traditional activities marketing and distribution. Instead, they are regarded as existing as a support and complement within these activities. The record labels’ role has therefore become more important in finding, building and operating artists’ careers.
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Bergquist, Olsson Frida, and Hanna Dahl. "Co-creators or puppets? : a study on AI-marketing’s role in consumers’ value co-creation." Thesis, Högskolan Kristianstad, Fakulteten för ekonomi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-22155.
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In recent years, AI has received increased attention in the field of marketing and is believed to grow even more in the future. It seems that the use of AI in marketing has a significant impact on consumer value creation. The purpose of this thesis is to explore how consumers experience the role of AI-marketing within the scope of the online customer journey, including how both positive and negative aspects of AI-based decision aids influence their value co-creation. Based on previous research, a conceptual model was created to determine whether consumers co-create or co-destroy value in the interactions with AI-based decision aids, as well as which types of values that are the outcomes. Three focus groups were used as a qualitative method to collect empirical data. Findings resulted in two main insights. Firstly, consumers experience the role of AI-based decision aids positively and can co-create values regarding economic and efficiency benefits, facilitation of information search, and more inspiring, personal and relevant experiences. Secondly, AI-based decision aids are also perceived negatively and contribute to co-destruction of value as well. Consumers experienced negative aspects regarding manipulation, limitations and loss of integrity and autonomy, as well as risks of overspending, being misled and distracted, and having irrelevant experiences. This thesis contributes with new insights into the consumer perspective of AI-marketing. Marketers can use these results to understand consumers’ value creation and avoid the negative aspects to achieve the best possible AI-marketing strategies.
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Sinnya, Utsav. "The role of customers on the co-creation of Service Climate in a restaurant setting: A Qualitative Study." Thesis, Umeå universitet, Företagsekonomi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88826.
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The benefits of customer co-creation of value in the service delivery process have been well established through recent literatures. However, despite the fact that there has been an increase in the awareness of the importance of customer behaviors in the service delivery process, little research has been done to investigate the role of customers and their influence in co-creating the service climate within organizations. This study captures the impact and effects of customer behaviors on the perceptions of employees towards the service climate of their respective restaurant firms.The overall objective of this thesis is to deepen the understanding of the role of customers in co-creating the service climates inside restaurant firms where co-creation of services occurs. For conducting this study, I have used the semi-structured interviews for data collection from six respondents (three customers and three employees) from three different restaurants within the city. Results indicate that customers’ participative and citizenship behaviors such as giving feedbacks, employees’ job appreciation and praise during direct interactions, advocacy through word of mouth, and sharing of knowledge and seeking of information that could benefit the firm influenced employees’ perception of their work climate. The results also showed that employees transfer these positive attitudes to their fellow employees through affective group tone through which the overall working climate within restaurants is improved.I believe that this study will be helpful to future scholars and researchers who wish to conduct further research on this particular topic as the findings from this study have increased the understanding of the role of customers in the co-creation service climates within restaurant organizations. The paper also discusses the theoretical and practical implications of the findings from this research at the end of the paper.
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Wennerholm, Elin. "Transitioning from a Goods-dominant to a Service-dominant logic : Visualizing the role of Remote Monitoring Systems." Thesis, Umeå universitet, Institutionen för informatik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-57087.
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The manufacturing industry is turning their attention from a solely product orientation view, to the creation of new value-adding services in order to increase their after-sales business. In this thesis, a case study was conducted in order to examine a manufacturing industry in their process of developing value-adding services. By exploring their processes in service delivery and studying their introduction of remote monitoring systems in their service distribution, the aim was to visualise the dimensions of a service system and how it changes with the introduction of an specific new technology. This study has shown that the introduction of remote monitoring systems, changes the relationship between the provider and the receiver, through the decrease of physical visits at the clients’ site, with the consequence that the close relationships between the provider and its receivers can vanish. Furthermore this study shows that remote monitoring systems affects the service system, through intertwining the technology and shared information. As the characteristics of the new technology remote monitoring systems enables new ways of information sharing and thereby becoming how the information between the provider and receiver is shared. Additionally, this study shows that in order to co-create value in a service system, the provider has to bear full responsibility in coming up with an acceptable value proposition and for the clearness in presenting the value proposal to the receiver.
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Dorval, Cynthia E. "Relational values in women's career role." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0019/MQ47998.pdf.
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Bullock, Nora B. "Examination of values instruction in education and the role of humanities in values education." Instructions for remote access. Click here to access this electronic resource. Access available to Kutztown University faculty, staff, and students only, 1988. http://www.kutztown.edu/library/services/remote_access.asp.
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Cooper, Elaine. "The role of values in the policy process." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=14448.
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Muniz, Elizabeth Jimenez. "The Role of Cultural Values in Organizational Attraction." Doctoral diss., University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3855.
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The United States' (U.S.) workforce is more diverse than in previous decades in terms of race, gender, and native language (Fay, 2001). Such demographic shifts have changed how organizations attract applicants and how they motivate, reward, and retain employees (McAdams, 2001). Furthermore, organizations benefit from diversity by: (a) attracting the best talent available in the workforce (Cox, 1993), (b) increasing their product marketability to customers (Deshpande, Hoyer, & Donthu, 1986; Redding, 1982), and (c) fostering creativity, innovation, problem solving, and decision making in employees (Thomas, 1999; Thomas, Ravlin, & Wallace, 1996; Watson, Kumar, & Michaelsen, 1993). Given such benefits, organizations should attend to initiatives that facilitate the attraction of applicants from diverse backgrounds. Research has demonstrated that applicants use information about human resource systems, such as rewards, to form judgments about the perceived fit between them and the organization (Bretz & Judge, 1994; Schneider, 1987). For instance, organizations with policies accommodating work and family issues attract applicants preferring such benefits. Because reward systems influence applicants' opinions about the relative attractiveness of organizations (Lawler, 2000), it is important to determine the factors that influence such preferences. Motivation theories, such as the Theory of Reasoned Action, suggest that preferences toward reward systems are guided by individuals' values (Fishbein & Ajzen, 1975; Vroom, 1964). Such values, in turn, cause differences in reward preferences and organizational attraction. The purpose of this study was to investigate the relation of individuals' cultural values to the attraction of organizations offering different kinds of reward systems. More specifically, it sought to test three hypotheses. Hypothesis 1 predicted that there would be a two-way interaction between collectivism and the type of organization on organizational attraction. Hypothesis 2 predicted that there would be a two-way interaction between individualism and the type of organization on organizational attraction. Hypothesis 3 predicted that there would be a positive relation between collectivism and subjective norms used in organizational attraction. To test the three hypotheses, data from 228 participants were analyzed to evaluate their level of attractiveness to two different types of organizations (i.e., career-oriented vs. family-oriented). Findings for the test of Hypothesis 1 indicated that there was a joint effect between collectivism and the type of organization on organizational attraction. The slopes of the regression lines for each type of organization (i.e., family-oriented and career-oriented) differed as a function of collectivism. The slope of the regression line for the family-oriented organization was steeper than the slope of the regression line for the career-oriented organization. Results for the test of Hypothesis 2 indicated a joint effect between individualism and the type of organization on organizational attraction. The slopes of the regression lines for each type of organization (i.e., family-oriented and career-oriented) differed as a function of individualism. The slope of the regression line for the career-oriented organization was steeper than the slope of the regression line for the family-oriented organization. Findings for the test of Hypothesis 3 showed that collectivism was related to subjective norms. Results indicated that the more collective the individual, the higher the subjective norms. In addition, supplementary analysis showed that individualism was not related to subjective norms. Taken together, results from the tests of the three hypotheses support components of the Theory of Reasoned Action, and the premise that values are a factor related to an individual's attraction to a particular organization. The current study showed that the cross-cultural values of individualism and collectivism help predict organizational attraction. Based on these results, practical implications, contributions to theory, study limitations, and future research are discussed for designing organizational attraction strategies for a culturally diverse workforce.Ph.D.
Department of Psychology
Sciences
Psychology PhD
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Zang, Jingjing. "Controlling the dominant time constant in cone photoreceptors : the role of Ca²⁺ concentration." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611483.
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Campos, Sánchez Alejandro. "The Role of Personal Values in the Entrepreneurial Process." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/289568.
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This work aims to explore different stages of the entrepreneurial process from the perspective of personal values as main predictors and guides of behavior. This work focuses on personal values for two main reasons: first, following the concept stated by Gartner (1988) about entrepreneurship being a role and a set of behaviors, and considering personal values as regulation agents for attitudes and thus for behavior. Second, personal values are desirable, trans-situational goals that vary in their importance as guiding principles in people’s lives and behavior (Schwartz, 1992).
Thus the main objective of this research is to explore the role that personal values play as determinants of attitudes and behavior oriented to different stages of the entrepreneurial process, and learn how the influence of personal values in this process may affect the decisions that the entrepreneurs take within the organization as well as influencing the expected outcomes. To address this general objective the following specific objectives are proposed:
- Analyze the literature of personal values and specifically those researches that have studied the role of entrepreneurs’ values on the entrepreneurial process.
- Analyze the relationship between personal values, a positive attitude toward entrepreneurship, and entrepreneurial intentions.
- Identify how an entrepreneur’s values can have a specific influence on the perception of growth and how these values have an impact on the process of growing of new ventures, specifically on the firm’s way of growing.
- To show the case of a company where the entrepreneur’s personal values have strongly influenced organizational culture and the process of growing.
In this sense, this work is focused on the role of personal values as factors that predict or influence attitudes towards the intention to create a new venture, the decision making regarding the creation process, and the way the entrepreneurs conceive of their company and decide to make it grow.
Chapter 1 presents the introduction and main objectives of this research. In Chapter 2, a review of the literature concerning theories on values is presented in order to narrow down the origin of the study; a set of definitions of values is presented to contextualize the concept and another literature review is presented to analyze the state of the art of the study of personal values related to entrepreneurship. Chapter 3 presents an empirical quantitative research study conducted among students at the University of Barcelona exploring the influence that personal values have on attitudes towards entrepreneurship and the link between them and entrepreneurial intention. Chapter 4 describes the relation that exists between personal values and the perception and expectation of growth of founders of new high-technology ventures: this chapter explores the role that personal values play in the way these founders conceive of their firms and what type of growing process their goals are aimed at. This research follows The Functional theory for analyzing entrepreneur’s values. Chapter 5 presents an in-depth case study of one firm in particular of those mentioned in Chapter 4. This firm provides a clear example of how the personal values of the founder are transmitted to the organization and how these values govern the life of the company. This chapter highlights the role of personal values as the basis of the philosophy of the company and hence of the decision making and strategy designing processes. In this last case, personal values are the key factor for the subsistence and growth of the company. Finally Chapter 6 presents a general discussion and the conclusions of the research as well as the implications for theory and practice, limitations of the present study, and future lines of research.
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Strauss, Tiiu. "The nature and role of chief education officers' values." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0009/NQ41512.pdf.
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McKay, Alexander M. A. "Toward more meaningful sexuality education : the role of values." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59656.
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This thesis is an examination of the role of values in the development of more meaningful school based sexuality education programs. There is a growing consensus among researchers and educators that presenting only physiological information is inadequate and that sexuality education should include a values component.The integration of values into sexuality education is highly problematic. Because of the potential for controversy regarding questions of sexual values, many sexuality educators have attempted to teach programs that are value free.
An ethical framework for the integration of values into sexuality education needs to be established. The act-centred and person-centred approaches to sexual ethics are compared and contrasted in terms of their suitability for sexuality education. It is proposed that a person-centred approach may provide a starting point of an ethical framework for the integration of values into sexuality education.
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Magill, Rebecca. "The role of values and personality in therapeutic alliance." Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/401232/.
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The first section of this thesis submission consists of a systematic literature review regarding the relationship between personality constructs and therapeutic alliance. A total of 17 studies met inclusion criteria and these pertained to four personality constructs; values, interpersonal style, personality organisation, and quality of object relations. Alliance was measured in a variety of ways which made it difficult to compare studies but results were divided generally in terms of patient-or therapist-ratings. Research supported the link between interpersonal style and alliance,and was limited althoughrelatively consistent regarding the correlation between alliance and the other personality constructs. There was a significant amount of variation in methodology,however, and where this was not the case it was a consequence of reuse of study data, which limits generalisability. The review identified a need for replication studies and descriptive rather than diagnostic measures, particularly regarding values and some forms of personality organisation. The second part contains an empirical research paper pertaining to the role of values in therapeutic alliance. A total of 102 patients with depression diagnoses and 19 therapists contributed data with75 matched dyads analysed. The hypothesis that there would be a mediation effect of alliance on dyad value similarity and depression outcome was not supported. There were, however,significant correlations between value similarity and alliance, and between alliance and outcome at six months. Clinical implications and future research are discussed.
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Hogan, Lindsey R. "The Role of Values in Psychotherapy Process and Outcome." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc804912/.
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Given the importance of client characteristics and preferences, and therapist expertise to evidence-based practice in psychology, the current study sought to contribute to the literature concerning the role of values in psychotherapy. Personal values of clients and trainee therapists in 29 dyads were examined for relationships between client and therapist values and associations with working alliance and outcomes. Although previous literature in this area has suggested that successful therapy is characterized by an increase in similarity of client and therapist values, the current study did not replicate this finding. However, client perceptions of therapist values were found to be important to working alliance and outcome. Findings are discussed in terms of suggestions for future research as well as implications for clinical practice, including the importance of discussing expectations and preferences with clients.
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Abdelaali, Fatma. "The role of Prostaglandin E2 in the pathogenesis of Autosomal Dominant Polycystic Kidney Disease." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/12374/.
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Rationale & Hypothesis: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common genetic cause of end stage renal disease (ESRD). Cyst formation in ADPKD requires epithelial cell proliferation and fluid secretion into closed cyst cavities. These effects are mediated mainly by elevated intracellular cAMP levels which induce both cell proliferation and increased fluid secretion. Prostaglandin E2 (PGE2) has been shown to increase intracellular cAMP levels and we and others have shown that its receptor (PTGER2) is increased in renal cyst epithelia possibly leading to increases in cAMP levels in these cells. This study was designed to test the hypothesis that blocking PGE2 activation might have a therapeutic role in reducing cyst growth in ADPKD. Methodology: Taqman qPCR, Western blotting, immunohistochemistry and ELISA for cAMP level were used to determine the expression of PTGER2 and PTGER4 in normal and ADPKD samples. Kidney epithelial cells derived from patients with ADPKD, non-ADPKD controls and MDCK cells were tested for their ability to form cysts or tubules in 3D cultures using a variety of extracellular matrices. The effect of selective PTGER2 and PTGER4 antagonists on cystogenesis was determined in 3D cultures. Furthermore, I tested the effect of PGE2, PTGER2 and PTGER4 antagonist on cell proliferation and apoptosis. Levels of intracellular cAMP in cystic human cells, and control cells were measured by commercial ELISA assays. Results: PTGER2 mRNA and protein levels were significantly increased in cells and tissue sections derived from patients with ADPKD compared to normal controls and also in inducible kidney specific PKD1 knock-out mouse models compared to wild-type littermates. In human 3D cyst assays, PTGER2 and PTGER4 antagonists inhibited cytogenesis in a dose dependent manner. Furthermore, PTGER2 and PTGER4 antagonists inhibited cystic cell proliferation and increased apoptosis compared to the control cells. Conclusions: These results suggest that the use of specific PTGER2 and PTGER4 receptor antagonists could be effective in slowing cyst growth in human ADPKD.
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Mentor, Marcelle. "The role of values and corporate culture in people management." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/50186.
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Thesis (MPhil)--Stellenbosch University, 2004.ENGLISH ABSTRACT: The business world has seemingly become hit by, or perhaps it has been more exposed of its unethical and morally bad decisions and procedures. One just has to follow the businessrelated issues and one becomes aware of events of corruption, greed, fraud, embezzlement, theft, nepotism and so forth. This is not just an occurrence in South Africa, but a global phenomenon. However, as South Africa approaches its tenth year of democracy, and the move towards the realization of our President's vision of an African Renaissance, there is an increasing awareness that a commitment to management by acceptable values is needed to remove negativity around management processes and practices in South Africa. We have to move to a culture of management where people are the central aspect around which good management revolves. As the forerunners of The African Renaissance, we need to engage with the concept of "Ubuntu", and truly realize that value-management is really that - being people through other people. We need to accept that we should be people driven, inclusive of every single person to be able to achieve the goals we set out for our companies. Emotional intelligence is vital if one bases a style of management on a people directed goals and orientations. When we look at each other through empathetic eyes this allows for consideration of others and ultimately allows for positive change and growth in an organization. To be able to move effectively towards such a management style is not as easy as discarding a predominantly Eurocentric style and embracing an African one. There is the element of human beings that plays a vital role. The values of an individual, the norms and beliefs that that individual holds dear, is pivotal to the structure of organizational culture. It is the stance of this thesis that each individual is responsible, in one way or another, for the structure and make up of the organizational culture of which it is a part. This thesis looks at research in this regard and how the findings could be applied in the South African corporate world to help facilitate effective transformation.
AFRIKAANSE OPSOMMING: Die besigheidswêreld word oënskynlik gebombardeer - of moontlik word dit net meer blootgestel aan die onetiese en moreel verkeerde besluite en prosedures. Dit is slegs nodig om te let op besigheidsaangeleenthede om gevalle van korrupsie, bedrog, hebsug, diefstal, nepotisme, en so voorts te bespeur. Bogenoemde gevalle kom nie slegs voor in Suid Afrika nie, maar is 'n universele verskynsel. Soos Suid Afrika sy tiende jaar van Demokrasie nader en daar 'n beweging is in die rigting van ons President se visie vir 'n Afrika Renaissance, is daar 'n toenemende bewuswording van die feit dat toewyding aan bestuur deur (aanneemlike) waardes noodsaaklik is om negatiwiteit rondom bestuurprosesse en - praktyke in Suid Afrika te verwyder. Ons moet ons beywer om te beweeg na 'n kultuur van bestuur waar individue die fokuspunt is te midde van voortreflike bestuurstyle. As die voorlopers van die Afrika Rennaissance moet ons meer verbind wees tot die konsep van "Ubuntu" en werklik besef dat waarde-bestuur inderwaarheid mens-gesentreerd behoort te wees. Ons moet die uitdagings aanvaar om gedissiplineerd op te tree en sorg te dra dat alle mylpale, wat deur die maatskappy daargestel word bereik word deur die optimale benutting van elke individu binne die maatskappy. Emosienele intelligensie is van die uiterste belang as die besigstyl gefundeer is op die beginsel van mens-gerigte doelwitte en ingesteldhede. Daar moet 'n kultuur gekweek word van empatie en konsiderasie vir ons medemens, wat uiteindelik positiewe veranderinge en groei binne die maatskappy sal bevorder. Om effektief in die rigting van so 'n bestuurstyl te beweeg, is nie bloot 'n geval van wegdoen met 'n oorwegend Eurosentriese styl en die aagryp van 'n Afrika - styl nie. Die menslike faktor speel'n beslissende rol. Die waardes van 'n individu, die norme en oortuigings wat vir hom of haar belangrik is, is van deurslaggewende belang vir die struktuur van organisatoriese kultuur. Hierdie tesis ondersoek narvorsing in hierdie verband en kyk hoe die bevindinge toegepas kan word in die Suid Afrikaanse korporatiewe wêreld om effektiewe transformasie te help fasiliteer.
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Drake, Melanie Lee. "The role of values in educational leadership: an interpretive study." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1003640.
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This study set out to investigate the role of values in educational leadership. The renewed interest in values in both educational and corporate environments in South Africa places new pressures on members in leadership positions especially in school life. Schools are described as the ‘nurseries’ of values. The understanding of the abstract nature of values, as well as instrumentalising and implementing values in vision statements and organisational life, poses challenges to present and future school leaders. This study, based in the interpretive paradigm, is an in-depth investigation into the role of values at a former model C primary school in the Eastern Cape. Through the use of observations, document analysis, focus groups and interviews as data collection tools, this research highlights the importance of values in school leadership and how this impacts the life of the school leader. This case-study research combines theoretical and contextual frameworks to question the nature of values in leadership and uses the real-life experiences of these school leaders to resonate with current understandings of values in leadership and organisational culture. The importance of understanding these complexities in the lives and experiences of these school leaders cannot be underestimated. My findings highlight the tensions between leading successful schools (task/person efficiency) and remaining congruent with the need for leadership for social justice in post-apartheid educational institutions. The uniqueness of the school environment (‘families’ and ‘communities’) is also featured and resonates with previous literature. Through the lens of emerging leadership trends, we discover these school leaders’ understandings of values in their daily lives: they do what they are and this is reflected in this school’s unique organisational culture, which could be said to ‘transcend’ present leaders’ influence. Finally I propose that further research is necessary in order to broaden our understanding of the unique role of values in educational leadership in South Africa.
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Yan, Alan S. M. Massachusetts Institute of Technology. "The role of values & practical identities in mental wellbeing." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122314.
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This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Thesis: S.M. in Engineering and Management, Massachusetts Institute of Technology, System Design and Management Program, 2019
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 133-137).
More than 300 million people in the world suffer from depression. While traditional psychotherapies like cognitive behavioral therapy (CBT) continue to be effective for treating depression, a newer therapy known as acceptance and commitment therapy (ACT) has surfaced in recent decades that employs mindfulness and values-based techniques, inter alia, not explicitly targeted in CBT. Significantly influenced by ACT, this thesis offers a direct, externalized means by which individuals can interact with their value systems. Specifically, I present Psyche - a novel computer-based psychological intervention that is designed to help individuals not only better understand what they value but also better align their actions with their values. This thesis posits that such intentionality vis-à-vis our values will improve mental wellbeing. A two-week randomized controlled trial conducted on 29 participants compared Psyche (mind mapping one's value system) to an active control task (journaling). Both groups performed similarly for every therapeutic outcome measure. Given the fact that journaling is widely held to be therapeutically efficacious on its own and that the trial was a short two-week trial, the findings were encouraging. In addition to examining Psyche through the lens of therapeutic efficacy, I assess its ability to engage users.
by Alan Yan.
S.M. in Engineering and Management
S.M.inEngineeringandManagement Massachusetts Institute of Technology, System Design and Management Program
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Quratulain, Samina. "Moderating role of individual-level cultural values and role : Definition effects on social exchange relationships." Aix-Marseille 3, 2010. http://www.theses.fr/2010AIX32038.
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L’objectif de la présente recherche est de tester un modèle qui intègre la justice organisationnelle, les comportements de citoyenneté organisationnelle (OCB), l’OCB comme rôle-définition et les valeurs culturelles en vue d’examiner leurs relations en privilégiant une approche causale. Chacun de ces quatre concepts a engendré de son côté une abondante littérature et il est étonnant de constater qu’ils n’ont jamais été associés au sein d’un même et seul modèle. Dans ce modèle, la justice organisationnelle est présentée comme un déterminant des comportements de citoyenneté, et l’OCB rôle-définition et les valeurs culturelles sont des modérateurs du lien entre justice et l’OCB. Les comportements de citoyenneté organisationnelle comprennent des activités qui sont pro sociales dans leur nature et d'aide à l'efficacité d'organisations. Dans le contexte de travail, les individus confrontent fréquemment des pressions vers la maximisation de profit et la promotion personnelle, il n'est pas étonnant pas de prévoir que le souci de promouvoir le bien-être de tous pour d'efficacité organisationnelle soit camouflé. Les conditions de travail créent des pressions contradictoires sur les employés, vers l'égoïsme (par exemple, faire attention à son propre bien-être et à ses propres intérêts) d’une part et le désintéressement (par exemple, donner de soi-même pour le bien-être commun de tous les travailleurs) d’autre part. Les deux questions suivantes (« quand les salariés sortiront-ils de leur poste pour aider les autres collègues et l'organisation dans laquelle ils sont employés ? » et « dans quelle mesure le contexte organisationnel et/ ou les différences individuelles sont responsables de promouvoir ou décourager telles activités de pro sociale de la part des travailleurs ? ») ont besoin de réponses. Nous avons montré que les effets principaux des perceptions de la justice organisationnelle sur l’OCB des employés ne se produisent pas bien dans un échantillon de travailleurs pakistanais tirés de diverses organisations au Pakistan. Ceci suggère que les explications de l'échange social en fonction de la justice-OCB ne s’appliquent pas complètement aux employés pakistanais au Pakistan. La justice distributive a montré des liens cohérents avec certains aspects de comportements de citoyenneté, la justice interactionnelle prédit deux dimensions de l’OCB mais la justice procédurale n'est pas liée à toutes les dimensions de l’OCB. Nos résultats ont montré que les perceptions des employés concernant leur définition du rôle de l’OCB sont associées aux comportements de l’OCB actuels. Les employés qui croient que OCB est une obligation de rôle sont enclins à s'engager dans le comportement considérant l'aspect important du travail et parce que les employés qui perçoivent l’OCB comme extra-rôle sont enclins à répondre à un traitement injuste perçu par réciprocité et diminuent les contributions à la citoyenneté. Nos résultats ont suggéré que si une relation proche existe entre les employés et l'organisation, le comportement de citoyenneté est plus susceptible de se produire. Pour les salariés qui ont une faible orientation sur l'individualisme/collectivisme, les perceptions de justice peuvent accroître le taux d'engagement des comportements de citoyenneté à travers la formulation de l'échange social. Les résultats ont été moins puissants pour la valeur culturelle de distance hiérarchiqueThis study explains the concept of Organizational Citizenship behavior (OCB) in Pakistani work context. Citizenship contributions comprise of those activities which are prosocial in nature and help in effectiveness and efficiency of organizations. Considering the job context, where individuals frequently confront pressures toward profit maximization and self-promotion, it is not surprising to expect that concerns about promoting the welfare of all for the sake of organizational effectiveness may be camouflaged. The workplace conditions place contradictory demands on employees towards both selfishness (e. G. , looking after one’s own welfare and interests) and selflessness (e. G. , giving of oneself for the common welfare of all workers). Therefore following questions need elaboration and some precise answers are necessary regarding ‘when will people go out of their way to help others and the organization in which they are employed?’ and ‘to what extent the organizational context or individual differences are responsible for promoting or discouraging such prosocial activities on the part of the workers?’Theoretical and empirical progress in the field of organizational justice and citizenship behavior suggested that citizenship contributions are forms of expression through which people might readily express their feelings of equity or inequity. The relationship of employee and organization established on the basis of exchange of fair treatment was termed as social exchange relationship. Such a relationship is believed to exist outside the formal contract; and the contributions expected from each party are usually unspecified. The social exchange relationship between justice and OCB has received overwhelming support in the organizational behavior literature. The first objective of our study is to replicate and test the generalizability of social exchange explanations in Pakistani work context. Secondly, we tried to identify certain factors which may act as boundary conditions for the functioning of social exchange relationships. Employees’ in a similar work context may have different value orientations and /or beliefs about their job duties, thus having different conceptions of required and extrarole aspects of their job. W hypothesized the moderating influences of individual cultural orientations (individualism/collectivism, & power distance) and employee role-definitions on social exchange relationship (justice – OCB). Our study participants were employees of private sector organizations. Matching questionnaires were distributed to supervisors and subordinates in each company. Our results showed that social exchange explanations of justice-OCB relationships do not replicate well in Pakistani work context, as we found the significant effect of only distributive justice on OCB dimensions, marginal effect of interactional justice while no effect of procedural justice was found. Individualism/collectivism was a stronger moderator of justice-OCB relationships as compared to power distance. The moderating effect of individualism/collectivism were significant for OCB dimensions of helping and sportsmanship, while moderating effect of power distance was found for compliance and sportsmanship dimensions of OCB. The individual cultural values were found as predictor of OCB role definitions (helping and civic virtue dimensions) in high justice conditions. The moderating role of OCB- role definitions was confirmed only for the effect of distributive justice on helping dimension of OCB. Generally, we can conclude that we found support for moderating influences of individual level cultural values and OCB role-definition on justice-OCB relationships
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Gomer, Richard C. "Values in technology and practice : using Activity Theory to consider the role of values and technology in everyday activities." Thesis, University of Southampton, 2018. https://eprints.soton.ac.uk/421035/.
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We have incorporated technology in many of our everyday activities like working, socialising, eating and exercising. These technologies alter how we behave, and often do so quite deliberately in service of aspirations such as fitness or weight loss. Moreover, they frequently impinge upon the things that we think are important in our lives, our values; things like family, intimacy, privacy or the environment. A design methodology called Value Sensitive Design aims to account for values in technology design. However, VSD often focusses on the level of technological artefacts rather than the broader 'context of use' that a piece, or pieces, of technology might be deployed in. this limits the kind of values that it can consider, and the influence that artefacts have on the broader human activities in which they are embedded. To make it easier to consider values in contexts of use, it could be helpful to combine VSD with theories about how human activity is structured. One such theory, often used with HCI, is called Activity Theory. However, values are not explicitly accounted for within Activity Theory, which complicate its applicability to VSD. In this thesis, I report on investigations in two domains; privacy, and wellbeing; both of which bring values and everyday behaviours together, Through these investigations, I identify ways that Activity Theory can account for the observed practices, propose ways in which values can be made explicit within Activity Theory, and consider some design implications that arise. In doing so, I contribute a theoretical account of human activity in which values are explicit, which may be used as a model for conducting VSD at a 'context of use' level.
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Fitzhugh, Helen. "The role of organisational values in value creation : comparing social enterprises." Thesis, University of East Anglia, 2017. https://ueaeprints.uea.ac.uk/66835/.
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Social enterprises (SEs) are businesses that aim to create positive change for individuals and society. They are part of a society-wide discussion over how to create ‘social’ value, where the focus is often on finding efficient and effective means of ‘doing good’, but without consistent recognition that ‘good’ is a subjective term. Critical scholarship directs us to pay more attention to this subjectivity. This study explored how beliefs about what is ‘good’ - i.e. values - influence the experiences SEs provide for the people they aim to benefit. The mixed methods exploratory study drew on data from an online survey of SE organisational values and case-situated interviews across 14 English SEs. Quantitative and qualitative data were gathered on organisational values, decision-making and perceptions of value. The multi-faceted analysis approach reflected the influence of applied critical realism on the research design. The study found that certain ‘process’ values - i.e. beliefs about how SEs should operate - were surprisingly common across diverse cases. Coalescing around these values appeared to allow SE practitioners to downplay variation in ‘outcomes’ values - i.e. end-state preferences. While many SE practitioners described their preferences as common sense, clear differences in outcomes values belied claims of neutrality. These findings were used to posit a five point conceptual model of how values influence value creation. This academic contribution underpins two propositions with implications for policy and practice. Where values are instrumental in influencing the design and emphasis of activities carried out by SEs, the political implications of adopting different outcomes values should be more commonly recognised. Secondly, SEs should be aware that for the full translation of their intentions into perceptions of value creation, their activities must align with stakeholder expectations. Both participative and persuasive approaches to bringing about this alignment also carry with them politically significant choices.
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Öhman, Sebastian. "Game mechanics, Role play, and Narrative - Critically learning values through games." Thesis, Malmö universitet, Fakulteten för teknik och samhälle (TS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-20585.
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In 2018, the Swedish Parliament decided to make the UN Convention on the Rights of the Child acivil law, which will be implemented in the year 2020. The consequences of the decision are notunproblematic. The public debate, as well as research, shows that parents have a problem seeing howtheir style of parenting could correlate with the Convention’s legal text. The parents expresshopelessness towards the notion of child upbringing.This thesis is an exploratory pilot study aiming to prepare and generate new knowledge for a projectcommissioned by Save the Children with the goal to develop a game to decrease the knowledge gapbetween parents and children regarding what the Convention means for their relationship. The thesisalso asks the question: how can a game, played by parents and children meant to teach them about softvalues in accordance with the Convention look like.Beyond traditional qualitative research methods, this thesis used Research through Design anddeveloped a presumptive prototype for the project in order to explore the research subject. Findingsshowed that the games narrative and the power to change the narrative through player choices play anessential part in the participant’s ability to immerse in the game, and that this interactive narrative isclosely connected with the ability to learn. The thesis also shows designer directions to consider whendeveloping a game meant to teach the players about soft values.
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Gasson, Susan C. "The role of secondary values in the selection process in organising." Thesis, Queensland University of Technology, 2001. https://eprints.qut.edu.au/36349/1/Susan_Gasson_Thesis.pdf.
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This study develops a model (i.e., secondary values selection process - 2VS) to describe how values shared by individuals (i.e., secondary values) contribute to the creation of meaning and interpretation in organisations. Elements of the model are identified through exploration of two bodies of literature (a) cultural approaches to organisational studies, and (b) theories of evolution. Incorporated within the model are observable elements that support analysis and evaluation of the 2VS. Outcomes of the study are (a) development of a more complete understanding of the Selection Process in organising and (b) creation of a mechanism for cultural analysis of organisational settings.
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Roberts, Sean. "Dominant-power politics and ‘virtual’ party hegemony : the role of United Russia in the Putin period." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/952/.
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This case study examines the role of the political party United Russia in the rise of ‘dominant-power politics’, also termed ‘electoral authoritarianism’, that characterises the Putin period (2000-2008). Comparative literature identifies parties as important independent or explanatory variables in a range of regime outcomes, including the successful consolidation of democracy, but also in the establishment and consolidation of authoritarian rule. The impressive rise of United Russia in the Russian political system from late 2001 onwards, together with its co-occurrence with the growing strength of the Putin regime, suggests that the party was a factor in the outcome of the latter. This research first develops a theoretical framework to understand the role of parties in modern political systems and then applies this framework to explore the Russian case. Although a component of power in the Putin period, this research argues that the origins of United Russia in the ‘party of power’ phenomenon limit its value as an explanatory variable. Rather than a principal power in the emerging post-Yeltsin political order, United Russia is an agent of a powerful civilian executive, which remains beyond the control of any party. In this sense, the rise of United Russia in the Putin period is misleading. United Russia is an example of ‘virtual’ party hegemony; a reflection of the intentions and ability of non-party power-holders to project their power onto party-agents. This research contributes to existing literature on party politics in the post-Soviet space and Russian politics in the Putin period. In comparative terms, this study contributes to existing notions of party dominance and emerging literature on divergent regime trajectories in the post-Cold War period.
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Kulachek, Ya V. "The role of providing proper medical care in “golden hour” for victims with dominant abdominal trauma." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19676.
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Muehler, Craig G. "The role of the Navy core values in Christian counseling an exploration in integration for the Navy chaplain /." Online full text .pdf document, available to Fuller patrons only, 2001. http://www.tren.com.
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Yoyo, Vuyisa. "The role of African leadership values in achieving employee engagement in firms." Thesis, Nelson Mandela University, 2017. http://hdl.handle.net/10948/13392.
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Firms have been largely characterised by competition and this necessitates that organisations leverage on their own competitive advantage in order to stay relevant to their customers. This is applicable to organisations whether they sell products or render services. Employees become key in assisting organisations to ensure that they deliver quality services or products to these customers, as they are mostly the ones that liaise with these customers. Employee engagement becomes an important factor that needs to be understood together with the leadership values that can be utilised to increase employee engagement. Understanding the role of leadership values in achieving employee engagement is essential as this will assist management to practise and encourage the implementation of these values in their organisations. The aim of this study to assist organisations to improve employee engagement by investigating the leadership values that influence the increase in employee engagement. This study is specifically looking at investigating the role that African Values in Leadership (AVL), as measured by communalism, cooperativeness, selflessness and collectivism, play in the achievement of employee engagement in firms. An empirical study, consisting of a mail survey was conducted amongst 109 employees of the State Owned Enterprises (SOEs) in the Eastern Cape Province. The purpose of the study was to investigate the extent and leadership determinants of employee engagement in the SOEs. The key findings indicated that AVL played a vital role in achieving employee engagement. Important values that were found to be significant in increasing employee engagement were selflessness, collectivism and cooperativeness. Furthermore recommendations were made to management to ensure that they encourage employees to practise AVL and also lead by examples through modelling these values to foster employee engagement in SOEs.
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Chun, Ken. "The role of cultural values in evaluating brand extensions : individualism versus collectivism." Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/29484.
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When launching brand extension strategies globally, It is very important for today’s brand marketers to understand the differences in those countries with high cultural diversity such as South Africa,. This research intends to investigate the role that a consumer’s cultural value plays in evaluating brand extensions, in the context of the cultural dimension of individualismcollectivism, in order to close the theoretical gap in this area.This research is quantitative and causal in nature, and used an experimental factorial design in the conduct of the research. Triandis’ scales were used in the questionnaire design, and 161 MBA students participated in the experiment at GIBS. The research results disprove that cultural values play a role in evaluating brand extensions, and there was insufficient evidence to prove that individualists differ from collectivists in evaluating brand extensions. Nevertheless, the research results found that there are some positive interaction effects between the product category relatedness and product involvement in the process of brand extension evaluations.Dissertation (MBA)--University of Pretoria, 2012.
Gordon Institute of Business Science (GIBS)
unrestricted
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Shebaya, Mariam. "Leadership development : the role of developmental readiness, personality dispositions,and individual values." Thesis, Aston University, 2011. http://publications.aston.ac.uk/16039/.
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Increased awareness of the crucial role of leadership as a competitive advantage for organisations (McCall, 1998; Petrick, Scherer, Brodzinski, Quinn, & Ainina, 1999) has led to billions spent on leadership development programmes and training (Avolio & Hannah, 2008). However, research reports confusing and contradictory evidence regarding return on investment and developmental outcomes, and a lot of variance has been observed across studies (Avolio, Reichard, Hannah, Walumbwa, & Chan, 2009). The purpose of this thesis is to understand the mechanisms underlying this variability in leadership development. Of the many factors at play in the process, such as programme design and delivery, organisational support, and perceptions of relevance (Mabey, 2002; Day, Harrison, & Halpin, 2009), individual differences and characteristics stand out. One way in which individuals differ is in their Developmental Readiness (DR), a concept recently introduced in the literature that may well explain this variance and which has been proposed to accelerate development (Avolio & Hannah, 2008, 2009). Building on previous work, DR is introduced and conceptualised somewhat differently. In this study, DR is construed of self-awareness, self-regulation, and self-motivation, proposed by Day (2000) to be the backbones of leadership development. DR is suggested to moderate the developmental process. Furthermore, personality dispositions and individual values are proposed to be precursors of DR. The empirical research conducted uses a pre-test post-test quasi-experimental design. Before conducting the study, though, both a measure of Developmental Readiness and a competency profiling measure are tested in two pilot studies. Results do not find evidence of a direct effect of leadership development programmes on development, but do support an interactive effect between DR and leadership development programmes. Personality dispositions Agreeableness, Conscientiousness, and Openness to Experience and value orientations Conservation, Open, and Closed Orientation are found to significantly predict DR. Finally, the theoretical and practical implications of findings are discussed.
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Conix, Stijn. "Radical pluralism, ontological underdetermination, and the role of values in species classification." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274358.
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The main claim of this thesis is that value-judgments should play a profound role in the construction and evaluation of species classifications. The arguments for this claim will be presented over the course of five chapters. These are divided into two main parts; part one, which consists of the two first chapters, presents an argument for a radical form of species pluralism; part two, which comprises the remaining chapters, discusses the implications of radical species pluralism for the role of values in species classification. The content of the five chapters is as follows. Chapter 1 starts with a discussion of the theoretical assumptions concerning species and natural kinds that form the broad framework within which the arguments of the thesis are placed. The aim of this chapter is to introduce a set of relatively uncontroversial assumptions that frame the rest of the thesis. On the basis of these assumptions, chapter 2 presents an argument for radical species pluralism. The chapter substantiates this argument with a broad range of examples, and compares this position to other forms of species pluralism. Chapter 3 returns to the main interest of the thesis, namely, the role of values in species classification. It introduces the notion of values and presents an argument for the value-ladenness of taxonomy on the basis of the considerations in the first two chapters. It then sketches three important views on values in science in the literature. Chapter 4 argues that the case presented in chapter 3 provides strong support for one of these views, called the ‘Aims View’, and against two other prominent views, called the ‘Epistemic Priority View’ and the ‘Value-Free Ideal’. The resulting view, in line with the Aims View, is that value-judgments should play a particularly substantial role in species classification. Chapter 5 then considers the popular assumption that these value-judgments in taxonomy commonly take the shape of generally accepted classificatory norms, and argues that this assumption is not tenable. Finally, a brief concluding chapter points at some implications of the claims and arguments in this thesis.
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Dolan, Mary A. "Socioeconomic status and sex role values as determinants of divorce among women." CSUSB ScholarWorks, 1995. https://scholarworks.lib.csusb.edu/etd-project/1001.
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Smith, Abigail O. "Defining the Role of c-Jun N-terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1141.
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Polycystic kidney disease is an inherited degenerative disease in which the uriniferous tubules are replaced by expanding fluid-filled cysts that ultimately destroy organ function. Autosomal dominant polycystic kidney disease (ADPKD) is the most common form, afflicting approximately 1 in 1,000 people. It primarily is caused by mutations in the transmembrane proteins Polycystin-1 (PKD1) and Polycystin-2 (PKD2). The most proximal effects of polycystin mutations leading to cyst formation are not known, but pro-proliferative signaling must be involved for the tubule epithelial cells to increase in number over time. The stress-activated mitogen-activated protein kinase (MAPK) pathway c-Jun N-terminal kinase (JNK) promotes proliferation in specific contexts and is activated in acute and chronic kidney disease. Previous work found evidence of JNK activation in cystic tissues (Le et al., 2005) and others showed that JNK signaling is activated by aberrant expression of PKD1 and PKD2 in cell culture (Arnould et al., 1998; Arnould et al., 1999; Parnell et al., 2002; Yu et al., 2010) but the contribution of JNK signaling to cystic disease in vivo has not been investigated.
This body of work describes the use of conditional and germline deletion of Pkd2, Jnk1 and Jnk2 to model ADPKD and JNK signaling inhibition in juvenile and adult mice. Immunoblots and histological staining were used to measure JNK activation and evaluate the effect of JNK deletion on cystic disease. Results show that Pkd2 deletion activated JNK signaling in juvenile and adult mice. Reduction of JNK activity significantly reduced cystic burden in kidneys of juvenile Pkd2 mutant mice. This correlated with reduced tubule cell proliferation and reduced kidney fibrosis. The improvement in cystic phenotype was driven primarily by Jnk1 deletion rather than Jnk2. JNK signaling inhibition in adult Pkd2 mutants significantly reduced liver cysts when mice were aged six months. JNK inhibition reduces the severity of cystic disease caused by the loss of Pkd2 suggesting that the JNK pathway should be explored as a potential therapeutic target for ADPKD.
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Bednarek, Antje. "Young Scottish conservatives and conservative values a qualitative study of the role of values and evaluation in young Scottish conservatives’ everyday lives." Thesis, University of Aberdeen, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554297.
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This thesis presents a sociological exploration of the values that underlie contemporary Scottish Conservatism. The empirical focus was on a group of young members of the Conservative Party, with whom I carried out twenty qualitative interviews and participant observation for the duration of one year, and on their specific understandings of what Conservatism means today. The group and the ways in which the members had made the decision to join the Conservative Party indicate a great variety of socioeconomic and ideological backgrounds in the Party, which contradicts the stereotypical image that Conservatives are rich and middle class. However, as a narrative analysis of five interviews shows, class-based evaluations entailing a valorisation of middle- and upper-class values and a concomitant deprecation of the working class mark many young Conservatives' social cognition. This is being disguised to an extent, in the interviews as well as in the daily practices that constitute being Conservative. Drawing on participant observation data to describe those, I show that the annual events cycle that young Conservatives participate in contains events that take place in public settings and those that occur in the privacy of inner-Party circles. In public, the Conservative Party is presented as egalitarian, warm and caring, whereas in private settings upperclass cultural practices dominate. The Conservative lifeworld is thus a bifurcated one. It is also one marked by tensions between different factions within the Conservative Party, which I also discuss.
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Moorhead, Timothy. "Values and legal order : the institutional role of the European Court of Justice." Thesis, University of Reading, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553152.
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Positivist and non-positivist theoretical accounts of the concept or practice of law have debated the role played by values as (possible) features of legal ordering or (possible) conditions of legality. These debates concern whether law is properly understood as a descriptively accessible social fact, or is linked to a discursively accessible realm of 'abstract' normativity. Such debates arguably fail to fully account for the sense in which values operate within the legal order of the European Union, an order which is based upon the realisation of a complex objective, that of European integration. This legal order illustrates that, providing the moral concerns associated with 'rule of law' legal orders are maintained, additional values relating to the achievement of a co-operative political, social or economic enterprise can operate as fundamental or higher legal standards. Union institutional practices, notably those of the Court of Justice, support a widening of the role of values within the theory and practice of law. A comparative method of inquiry, acknowledging diverse theoretical insights regarding law, combined with analysis of case judgments of the Court of Justice provides argumentative and evidential support for this proposition. The Treaty objectives direct the practices of Union and domestic courts (when seized with issues of Union law) in their legality review, 'rights-affirming' and interpretive functions within an institutional account of law and legal practice. The Court's practices highlight institutionally viable expressions of politically sensitive (to Member States) Union values. At the same time these practices illustrate the potential for specific objectives, including those associated with public international Treaties, to form a basic function or value of legal ordering. This proposition is compatible with received theoretical analyses of law while affirming their qualified development.
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Brown, Carol. "What motivates A-level students to achieve? : the role of expectations and values." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:8f1bd6e5-5038-4a86-95d4-b3845d78485b.
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Eccles' expectancy-value model of achievement motivation suggests that beliefs about ability and expectations for success are a strong predictor of grades and differences in task value underlie differences in motivation and achievement. This model has not been previously investigated in the context of high stakes examinations in the UK and this study therefore explores the relationships between expectations, values and A-level achievement in 930 students. This is important given the significance of these qualifications for future life pathways. Furthermore, studies examining the subjective task value (STV) patterns across school subjects, rather than domain specific ones, are rare, highlighting the additional importance of this work. A mixed methods design was used. A questionnaire collected information on a student's background (SES, gender, ethnicity), the expectations and STV attached to A-levels, and their future and general life expectations and values. Some of these relationships were also explored using 20 semi-structured interviews. The qualitative data illustrated that studying A-levels confirmed aspects of students' identity but also facilitated changes to their goals and academic skills, having positive effects, contrary to the argument that high stakes assessment has a negative impact on individuals. Unsurprisingly parents and teachers were perceived to be influential. As predicted, expectations and values were related to A-level achievement. As there is a lack of research into the effects of these variables on A-level outcomes these findings are valuable. Eccles' original three factor model of STV could not, however, be supported. In this research the utility construct was removed. Further exploration of the STV construct is warranted. Socio-economic status was positively related to both achievement and expectations about achievement. Girls had lower expectations but placed higher value on their A-levels. There were, however, no gender differences in achievement. Employing the expectancy-value model in this UK context has been useful in explaining the motivational patterns underlying A-level qualifications and the findings have implications for enhancing outcomes and narrowing educational gaps in this student population.
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Mahlati, Malixole Percival. "The medical profession in a transforming South Africa society : ideals, values and role." Thesis, Stellenbosch : Stellenbosch University, 2000. http://hdl.handle.net/10019.1/51996.
Full textAbstract:
Thesis (MPhil)--Stellenbosch University, 2000.Some digitised pages may appear illegible due to the condition of the original hard copy.
ENGLISH ABSTRACT: Medicine in our country is under severe stress, brought about by internal and external forces that need a response from the medical profession. The profession's attempts and response will fall short unless the profession itself is aligned with the new social ethos and the responses are based on the profession's inherent values. Problem Statement: Medical doctors have always been highly valued in society because of the duty they have when illness and disease set in. As individuals, doctors have fulfilled other important roles in the communities where they work. These include giving advice to young people on career choices, counseling on various matters and provision of material help where there is need. This profession has for a long time been shrouded in mystery, being a trade learnt by a few. All these factors contributed to their social standing increasing phenomenally. There is a view that this has also led to public perceptions that doctors are the rich untouchable elite who have no interest or are unconcerned about problems faced by society. The medical profession faces a challenge that is more significant because of the value placed on it by society. The numerous submissions by the victims of human rights abuses to the Truth and Reconciliation Commission have cast a shadow of doubt on the medical profession for its complicity in these acts. The present government has declared transformation of health care as one of its top priorities. The response of the medical profession to this initiative has so far not led to any significant changes of public perception that the profession is unwilling to participate in the transformation of our society. The challenge and subject of discussion in this thesis therefore is: "What is the ideal role of the medical profession in a transforming South African society?" The medical profession, being the nerve centre of health care, has a big responsibility in social transformation. Doctors stand accused as a collective for failing to protect the human rights of patients and not living up to the standards of ethics required of them when patients' rights were violated. The Truth and Reconciliation Commission record of the hearings into the role of the professional organisations in health is used in this thesis to illustrate how serious society views the medical profession's role in the human rights abuses of the past. Based on the T. R. C's report and the assumption that society traditionally places high value on the medical profession, I conducted a survey among South African doctors to test their attitudes towards a range of policy and transformational issues. The unit of analysis was the medical doctors who are in active practice in South Africa in whatever mode of practice. The survey sought to explore the awareness of the respondents about a range of transformation policy changes and invite their comments on the role that they envisage for the medical profession in the process of transformation of society. There is unfortunately scarcity or a lack of applicable South African literature on this topic thus limiting local material for referencing. The search of international literature only yielded the subject of the study of professional values and not necessarily the role of a medical profession in a transforming society. The medical profession has to re-visit its foundations, analyse its history and map out its future in the context of the South African realities. It must find a way of aligning itself with the new ethos and diverse cultures South Africa possesses. Medicine has its own traditional goals and values derived and adapted from society's diverse cultural value systems. With its national and international networks, the inherent knowledge and skills that it possesses, guided by an ethical code, the Hippocratic Oath that serves as a public promise, it influences policy on the country's health care system - a mechanism that government uses to provide a basic human need. The medical profession therefore has to be responsive to the needs of society as much as society needs to support the profession. This thesis explores the role that the profession should play in a transforming South African society. The argument is that this can only be done through the profession examining its values and aligning itself with broader societal value systems, the moral and social norms. It is further argued that visible realistic commitment by the profession to public health will lead to an improvement in its public image. It is the actions or non-actions of the majority that the public notices. The majority of respondents to the survey have indicated that they approve of the transformation policies in health but that they may differ in the way they were introduced.
AFRIKAANSE OPSOMMING: Die geneeskunde in ons land is onder geweldige druk as gevolg van interne en eksterne faktore en dit is nodig dat die mediese beroep reageer. Dit sal die beroep egter nie help om te reageer indien sy lede hulle nie met die nuwe maatskaplike etos vereenselwig nie en die reaksie op die inherente waardes van die mediese beroep geskoei word nie. Probleemstelling Mediese dokters is nog altyd baie hoog geag deur die gemeenskap as gevolg van die verpligting wat hulle het om na mense om te sien wanneer hulle siek word. In hulle individuele hoedanigheid het dokters ook ander belangrike bydraes tot hulle gemeenskappe gelewer. Dit sluit in: advies aan jong mense oor loopbaankeuses, berading en die verskaffing van finansiele hulp waar nodig. Die beroep as sulks was egter vir baie lank ietwat van 'n misterie omdat dit 'n vakrigting is waarin baie min mense hulle kon bekwaam. Al hierdie faktore het die maatskaplike aansien/waarde van dokters geweldig verhoog. Daar is ook diegene wat van mening is dat hierdie faktore aanleiding gegee het tot die openbare mening dat dokters 'n ryk en onaantasbare elite is en glad nie in die probleme van die gemeenskap belangstel nie. Die etlike voorleggings deur die slagoffers van menseregtevergrype aan die Waarheids- en Versoeningskommissie het ook vrae rondom die beroep se betrokkenheid by sodanige gevalle laat ontstaan. Die huidige regering het die transformasie van gesondheidsorg as een van sy grootste prioriteite verklaar. Die reaksie van die beroep hierop het tot dusver nie tot enige noemenswaardige veranderinge in die openbare mening dat dokters nie bereid is om aan die transformasie van ons gemeenskap deel te neem gelei nie. Wat is die ideale rol van die mediese beroep in die transformasie van die Suid- Afrikaanse gemeenskap? As die senusentrum van gesondheidsorg het die mediese beroep 'n groot verantwoordelikheid in maatskaplike transformasie. Dokters word kollektief beskuldig dat hulle nagelaat het om die menseregte van pasiente te beskerm en nie voldoen het aan die nodige etiese standaarde wat van hulle verwag word in die tyd toe pasienteregte geskend is nie. Die rekord van die verhore van die Waarheids- en Versoeningskommissie oor die rol van professionele gesondheidsorganisasies is vir die doeleindes van hierdie tesis gebruik om te illustreer hoe ernstig die gemeenskap voeloor die mediese beroep se rol in die menseregte vergrype van die verlede. Gegrond op die WVK-verslag en die aanname dat die gemeenskap die mediese beroep hoog ag, het ek 'n meningsopname onder 300 Suid-Afrikaanse dokters gedoen om hulle houding jeens 'n aantal beleids- en transformasiekwessies te toets. Die eenheid van analise was mediese dokters wat in die aktiewe praktyk staan, ongeag hulle praktykgebied. Die opname het gepoog om te bepaal wat die vlak van bewustheid by die respondente oor 'n aantal beleidsveranderinge gerig op transformasie is, en hulle uit te nooi om kommentaar te lewer op die rol wat hulle meen die mediese beroep behoort in die proses te speel. Ongelukkig is daar nie toepaslike Suid-Afrikaanse literatuur oor die onderwerp beskikbaar me. 'n Internasionale literatuursoektog het net studies rondom waardes opgelewer, en nie oor die rol van 'n mediese beroep in die transformasie van 'n gemeenskap nie. Die mediese beroep moet die grondslag van sy wese in oenskou neem, die geskiedenis analiseer en sy toekoms in die konteks van die Suid-Afrikaanse realiteite uitstippel. Die beroep moet 'n manier vind om homself met die nuwe etos en uiteenlopende kulture van Suid-Afrika te vereenselwig. Die geneeskunde het sy eie tradisionele doelwitte en waardes gekry en aangepas vanuit die uiteenlopende kulturele waardestelsels van die gemeenskap. Deur middel van sy nasionale en internasionale netwerke, inherente kennis en vaardighede, die leiding van 'n etiese kode, die Eed van Hippokrates wat as 'n belofte aan die publiek dien, beinvloed die mediese beroep die land se gesondheidsorgstelsel - 'n meganisme van die regering om in 'n basiese menslike behoefte te voorsien. Die mediese beroep moet daarom ingestel wees op die behoeftes van die gemeenskap in dieselfde mate as wat die gemeenskap die beroep behoort te ondersteun. Hierdie tesis ondersoek die rol wat die mediese beroep behoort te vervul in 'n Suid-Afrikaanse gemeenskap waar transformasie besig is om plaas te vind. Daar word geargumenteer dat dit net gedoen kan word indien die beroep sy waardes ondersoek en hom met die breer maatskaplike waardestelsels vereenselwig. Daar word verder geargumenteer dat 'n sigbare realistiese verbintenis van die mediese beroep tot openbare gesondheid tot die verbetering van sy openbare beeld sal lei. Dit is die optrede of nie-optrede van die meerderheid wat die publiek raaksien. Die meerderheid respondente in die meningsopname het aangedui dat hulle die transformasiebeleid vir gesondheid ondersteun, maar dat hulle verskil van die wyse waarop dit in werking gestel is.
40
Abdelmoteleb, Samir. "Values congruence and commitment : throwing the role of psychological climate into the mix." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/346354/.
Full textAbstract:
Studying the fit between employees and their organisations and the individual and organisational outcomes of this congruence has been an interesting topic for researchers over the past decades. However, the literature does not adequately address how this fit affects other organisational attitudes – in particular organisational commitment. In this study, a theory on the mechanism by which employees’ perception of person-organisation values fit impacts their affective organisational commitment and how this is impacted by their perceptions of the psychological climate is offered. Moreover, the study contributes to the literature through applying the Latent Congruence Model (LCM) developed by Cheung (2009a). Accordingly, all the hypotheses that pertain to values congruence, psychological climate and affective organisational commitment are simultaneously tested, controlling for the measurement errors. This SEM approach could be a useful analysis tool, especially as we know that, according to the simulation study of Cheung and Lau (2008), the bias in regression coefficients due to measurement error using path analysis may exceed 16% on average. Therefore, studying congruence under the frame of SEM in turn increases the accuracy and the significance of the congruence-related studies. The study was conducted in an Egyptian medium-sized textile organisation (N = 223). The results of the study supported the hypotheses that there would be positive relationships between affective organisational commitment and both perceived person-organisation values fit and psychological climate. Moreover, perceived person-organisation values fit demonstrated a positive impact on psychological climate. Importantly, psychological climate mediated the relationship between perceived person-organisation values fit and affective organisational commitment. The implications of these findings and directions for future research are discussed.
41
Dose, Jennifer J. "The role of diversity in group processes and outcomes : values and sex composition /." Connect to resource, 1995. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1250530325.
Full text
42
Cormack, Edith. "Values in psychotherapy : an exploration of their role and function in professional practice." Thesis, Abertay University, 2010. https://rke.abertay.ac.uk/en/studentTheses/e547d17b-02e4-4dd3-b982-e707a0101a45.
Full textAbstract:
This thesis explores the values of a group of practicing psychotherapists and examines the function these values have for their personal and professional lives with a view to both clarifying and deepening an understanding of the role of values in professional life and practice. The study is situated within a constructivist framework and also draws on social constructionist perspectives consistent with a sociohistorical approach to values within psychotherapy practice in a post modern era. The study is historically contextualised in relation to the place of values in the practice of care, and in respect of a critical review of the role of values in the profession of psychotherapy. Two studies were carried out. The first consisted of indepth interviews with eleven experienced, practicing psychotherapists, analysed using grounded theory methodology. A second study analysed a therapy session between a counsellor and her client in order to identify the values occurring in the interaction and to explore how these were managed. The results of these studies demonstrate that while the therapists acknowledged the value-laden nature of their practice, they were not aware of how these values impacted on the client, nor were they clear on the extent to which values influence was acceptable and ethical. While they rejected an authoritarian imposed morality, they were committed to the care of others and to their own development which they considered to be moral imperatives. Study two demonstrated that the therapist validated her client’s values when these were part of her own personal value system, but that the therapist’s values superseded those of the client when there was conflict between the client’s values and those of the therapist’s theoretical orientation. The implications of these findings for the practice of psychotherapy within a pluralistic culture are examined, and their relevance to the training and development of practitioners is discussed. Suggestions are made as to how the clarification and deeper understanding of values can improve therapist’s self knowledge and enhance an understanding of a client’s perspective. This thesis provides evidence that values are significantly important in both human life and therapeutic practice and highlights the need to create a coherent conceptual framework of values which is consistent with the prevailing cultural conditions. The thesis concludes that values give meaning and purpose to human life and are essential to human well being so are of significant importance in the profession of psychotherapy.
43
Meyer, Jonette. "The role of values, beliefs and norms in female consumers' clothing disposal behaviour." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/41121.
Full textAbstract:
In previous
years,
the
importance
of
sustainable
consumption
has
been
neglected,
and
as
a
result,
so
has
the
disposal
process.
This
has
lead
to
consumers
being
uneducated
about
environmental
issues
associated
with
waste
problems.
The
textile
industry
greatly
contributes
to
waste
problems;
however,
very
little
information
is
available
in
South
Africa
concerning
the
waste
management
of
the
textile
industry.
Furthermore,
very
little
research
has
been
done
in
this
country
regarding
consumer’s
clothing
disposal
behaviour.
South
Africa
is
a
country
with
various
cultures,
and
research
conducted
in
this
country
necessitates
consideration
of
consumers’
values,
beliefs
and
norms.
This
study
acknowledges
the
lack
of
sustainable
lifestyle
literature
in
a
country
such
as
South
Africa
that
has
an
emerging
economy
and
diverse
cultures,
and
therefore
provides
a
framework
that
emphasises theories
and
models
based
on
pro-‐environmental
behaviour.
The
framework
for
this
study
focuses
on
the
concepts
of
the
Value-‐Belief-‐Norm
Theory
and
the
New
Ecological
Paradigm
Scale
as
influencing
factors
for
clothing
disposal
behaviour.
For
this
study
the
clothing
disposal
methods
included
re-‐using,
recycling,
donation,
reselling
and
discarding.
© University of Pretoria
v
Furthermore,
both
the
Value-‐Belief-‐Norm
Theory
and
the
New
Ecological
Paradigm
Scale
are
new
to
the
consumer
behaviour
research
field
in
South
Africa.
The
study
was
conducted
in
the
City
of
Tshwane
and
a
sample
of
306
female
consumers
was
included.
Female
consumers
were
selected
as
it
has
been
found
that
females
tend
to
be
more
environmentally
concerned
than
men.
Respondents
were
reached
through
non-‐
probability,
purposive
and
snowball
sampling
methods.
A
quantitative
research
approach
that
included
a
cross-‐sectional
survey
design
was
used
for
descriptive
and
exploratory
purposes.
Respondents
completed
a
questionnaire
that
was
based
on
objectives
compiled
according
to
the
research
statement.
Data
was
coded
by
the
researcher
herself,
and
was
further
descriptively
and
statistically
analysed
by
statisticians
of
the
University
of
Pretoria.
The
results
for
the
study
indicated
that
the
majority
of
the
consumers
included
in
the
study
mainly
indicated
compassionate
value
orientations;
however,
they
showed
only
moderate
concern
towards
the
environment.
Nevertheless,
results
showed
that
the
majority
of
the
sample
predominantly
disposes
of
their
clothing
by
means
of
pro-‐environmental
clothing
disposal
methods
such
as
recycling,
re-‐using
and
donation.
It
was
however
found
that
different
value
orientations,
beliefs
and
norms
had
varied
influences
on
the
clothing
disposal
behaviour.
Ultimately,
the
findings
indicated
that
it
is
relevant
to
explore
consumer
behaviour
in
a
country
with
a
growing
economy
and
with
various
cultures,
since
values,
beliefs
and
norms
had
a
noteworthy
influence
on
consumers’
clothing
disposal
behaviour.Dissertation (MConsumer Science)--University of Pretoria, 2013.
gm2014
Consumer Science
unrestricted
44
McAllister, Margaret. "Enriching values : an educational criticism approach role of assessment in teaching mental health." Thesis, Queensland University of Technology, 1997.
Find full textAbstract:
This study focused on exploring student assessment approaches utilised by various teachers of mental health. Classrooms of three (3) teachers were selected to become
the subject of case studies that were described and analysed using an educational criticism method. The following evolved as major research questions:
What are the teacher's assessment values?
What effect does assessment have on enriching the learning process?
A qualitative approach was considered appropriate to address these questions because the nature of the enquiry was understanding rather than proof. Methods of
inquiry used for the study were
a) observation,
b) interviews with teachers and their
students, and
c) educational criticism as a medium for describing, analysing and presenting findings.
The case studies, each focussing in some way on mental health, produced rich descriptions of particular situations and prompted detailed analytical criticism from the researcher. Different themes about assessment of students in
psychiatric/mental health courses were uncovered and included:
• When assessment is reframed to mean pedagogy, instead of the more familiar notion as technique, it becomes part of teaching rather than an addition to it. In this way, the role of the teacher in promoting learning is enhanced and revalued. In relation to assessment, a teacher needs to have
technical expertise but more important are the creative ways a teacher invites students to think about and share approaches to assessment and practise the particular learning being assessed.
• Students who are learning the knowledge and practice of a discipline need guidance and support from their teachers. Furthermore, teachers have a commitment to the profession and to the community to graduate safe, effective practitioners. Therefore, assessment performs a dual role: in guiding and in judging.
Teachers are pressed with a fundamental tension between a desire to do justice to the content of a curriculum and to provide activities and pace that make it possible for students to engage with the subject matter, feel compassion for the people with whom they aim to work and develop
commitment to the profession. Some teachers recognise the inequalities that exist between teachers and students, and take effective action to reduce these inequalities without
surrendering the teacher's responsibility to assess students.
Some students prefer a passive role within the classroom but teachers can help overcome this resistance to active participation by easing students into the new role, by modelling approaches to learning and assessment, and by
providing regular, consistent, constructive formative assessment throughout the everyday classroom experience.
These themes were subsequently distilled into metaphors of teaching that reclaim the craft of teaching and assessment, remind teachers of the holistic role assessment can play within the classroom and may be used to guide future teacher action. These metaphors were teaching as a dance, a choir, and a journey. Woven into all of these images, is an understanding of assessment that appreciates assessment as a way of judging student progress: as a well performed dance and choir, or a successful journey. In order to diagnose specific areas in need of improvement, each these
events may be reduced to their component parts. Students may be assisted to achieve proficiency in component parts by listening to teacher's feedback.
However, a dance, choir, or journey can never be understood completely by examining one of their parts. So too, one cannot assess mastery of the subject matter simply by adding the sum of each assessment part. Mastery is decided when the dancer completes the dance, the singer performs in the choir, and the journey is complete. Metaphors such as these offer teachers insight into concepts like assessment by illuminating complexities and suggesting improved approaches to education.
45
Lane, Alyssa Caroline, and Alyssa Caroline Lane. "The Pathophysiology of Autosomal Dominant Adult-Onset Neuronal Ceroid Lipofuscinosis and the Role of Cysteine-String Protein Alpha." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625031.
Full textAbstract:
This thesis serves as a review of the current literature and knowledge surrounding
autosomal dominant Adult-Onset Neuronal Ceroid Lipofuscinosis, its underlying
mutations, and disease pathophysiology. ANCL has been extensively researched in the
past two decades and the major breakthroughs regarding this neurodegenerative disease
are highlighted in the following pages.
The mutations L115R and L116Δ in the DNAJC5 gene encoding cysteine-string
protein alpha have been identified as the underlying source of ANCL. Impaired
functioning of CSPα somehow leads to neurodegeneration, however its pathogenic
pathways remain unclear. Recognizing the mechanisms by which mutant CSPα may lead
to disease-onset is the key to understanding ANCL and, therefore, the focus of this
literature review.
First, a general introduction to various physiological pathways essential for
understanding ANCL is provided. This sets the stage for part II, in which the current
literature on NCL is consolidated, allowing the pieces of the ANCL puzzle to fall
together. This synopsis is given as persuasion for an overarching process of ANCL
disease pathology involving many complex mechanistic pathways combined.
46
Beedles, Monique Therese Frances. "The uncertain role of alliances in the strategic armoury of the dominant firms in the global pharmaceutical industry." Thesis, Queensland University of Technology, 2002.
Find full textAbstract:
This thesis aimed to address a gap in the strategic management literature whereby theories about the significance of alliances have been forwarded and accepted without adequate empirical evidence being provided to support their central thesis. The alliance activity of the dominant firms in the global pharmaceutical industry was studied and no consistent link was found between the involvement of these firms in research and development alliances and their performance over a range of indicators. This finding is not compatible with much of the current strategic management literature, which asserts that alliances are an essential part of the strategy of successful firms and that without these collaborative agreements, firm failure is inevitable. Further to this fmding, four of the firms were examined through detailed archival analysis over a longitudinal historical timeframe to determine the role of alliances in the overall
strategy of each firm. The strategic perspective taken in the research gives a holistic view of each firm through consideration of their alliance activity as well as a range of other important factors such as their acquisitions and divestments, executive changes, patents and marketing approvals, stock offerings, buy backs and legal proceedings. The results of this analysis show that successful firms may use one or more of a range of strategic
tools to ensure their continued profitability and ultimate survival. As an alternative to alliances, mergers or acquisitions may be used or as a third alternative, firms can choose to develop their internal resources. These fmdings support the concept, espoused by core management theorists, that strategy is unique. To address the lack of evidence in the literature, this research sought to gather evidence that would elucidate the nature of the connection between alliance activity and performance. For the dominant firms in the pharmaceutical industry the evidence has
shown that the role of alliances in the performance of these firms is uncertain and that there is no empirical basis for claims that alliances are essential to firm success.While further research may show that alliances are indeed imperative for small firms without the necessary capabilities, particularly those related to their human capital, to develop internally or the resources to grow through acquisition, there is no certainty that
the dominant firms in this industry are forced into such imperatives. The smaller and newer biotechnology firms gain their competitive advantage through their innovative
capacity to produce potentially valuable new molecules. However, these firms do not possess within their human capital the complete range of skills, nor do they posses within their infrastructure the physical capabilities required to materialize from the promising molecule a marketable pharmaceutical product. In order for the promise of their innovations to be realized they must seek external inputs. This could come in the form of venture capital, but the investments required are so large and the risk for the investors so great that this path is rarely followed. Instead these firms enter into a dependency relationship with a larger, more resource rich firm. In this way the large numbers of firms potentially involved in the industry are dominated by a small number of firms who have the means to maintain for their own benefit the established dependency
relationships. These dominant firms retain their strategic choice and may select from a range of options.
Indeed it is the very dominance of these firms that creates the dependence of the smaller firms upon them. These conclusions should force a rethinking of the approach to theory development in this area, and for business decision makers, the findings should encourage revision of their strategy using a holistic, firm based perspective, through a
recognition that the outcome of strategic decision making is always contingent upon the context in which the decisions must be made.
47
Morcom, Veronica Elizabeth. "Mediating classroom culture based on democratic values : an exploration of a teacher's facilitative role /." Access via Murdoch University Digital Theses Project, 2005. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20060502.153604.
Full text
48
Razavi, Tiffani D. B. "Values and occupational stress : the role of individual-organizational value congruence in the workplace." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342619.
Full text
49
Morcom, Veronica. "Mediating classrooom culture based on democratic values: an exploration of a teacher's facilitative role." Thesis, Morcom, Veronica ORCID: 0000-0002-0944-1705 (2005) Mediating classrooom culture based on democratic values: an exploration of a teacher's facilitative role. Masters by Research thesis, Murdoch University, 2005. https://researchrepository.murdoch.edu.au/id/eprint/207/.
Full textAbstract:
The aim of this research was to examine the teacher's facilitative role to engage students in Values Education (Curriculum Council, 1998) based on a cooperative and collaborative learning pedagogy. The study was conducted in a primary school classroom with thirty-one year 4/5 students aged 9-10 years of age.
During the research process the core shared values underpinning the Western Australian Curriculum Framework (Curriculum Council, 1998) provided the foundation to negotiate agreements for behaviour based on The Tribes process (Gibbs, 2001), which included mutual respect, in order to foster a safe, supportive and democratic classroom culture. The Tribes process was used to operationalise the teaching of values, social skills, cooperation and collaboration. Hart's (1992) collaborative framework informed the organisation of the classroom to create the conditions that supported collaboration amongst peers and the teacher.
An action research approach was used to reflect on the classroom context and provide a focus for a range of qualitative research methods. Multiple data sources such as teacher observations, interviews, student and teacher reflection logs and sociograms were used to triangulate findings from parents, students and teachers. A sociocultural perspective (Vygotsky, 1978) provided the conceptual framework for this study as the underlying assumption is that students learn from each other, mediated by the teacher or more capable peers. The focus on the action within the social context during the development of interpersonal relationships is a key feature of peer mediated learning, which complemented the processes chosen by the teacher researcher to elucidate how a safe, supportive and democratic classroom was created. Class meetings, group work and reflective practices were used to scaffold students' understandings of interpersonal relationships to promote a culture that was consistent with Australia's democratic traditions. Reflective practices in the classroom provided opportunities for new perspectives to be developed, as new knowledge and experiences were integrated with existing personal practical knowledge.
The major findings reflected the foci of student and teacher conversations about students' interpersonal skills and their ability to get along with each other. In the first phase of the study establishing positive 'relationships' based on trust, through teambuilding activities provided the impetus for the next phase of the study about 'leadership'. This phase continued for most of the study, and provided authentic opportunities for students to develop leadership skills, which permeated the last phase of the study about 'friendships'. Students established mutually beneficial relationships that broadened their views about discriminatory behaviours, friendship and leadership.
The major conclusions drawn from the study is that teachers play a significant role in mediating positive relationships amongst peers. Further, it was evident that the explicit teaching of core shared values (Curriculum Council, 1998) provided the foundations of productive and active citizenship during the process of creating the conditions for a safe, supportive and democratic classroom.
50
Morcom, Veronica. "Mediating classrooom culture based on democratic values: an exploration of a teacher's facilitative role." Morcom, Veronica (2005) Mediating classrooom culture based on democratic values: an exploration of a teacher's facilitative role. Masters by Research thesis, Murdoch University, 2005. http://researchrepository.murdoch.edu.au/207/.
Full textAbstract:
The aim of this research was to examine the teacher's facilitative role to engage students in Values Education (Curriculum Council, 1998) based on a cooperative and collaborative learning pedagogy. The study was conducted in a primary school classroom with thirty-one year 4/5 students aged 9-10 years of age.
During the research process the core shared values underpinning the Western Australian Curriculum Framework (Curriculum Council, 1998) provided the foundation to negotiate agreements for behaviour based on The Tribes process (Gibbs, 2001), which included mutual respect, in order to foster a safe, supportive and democratic classroom culture. The Tribes process was used to operationalise the teaching of values, social skills, cooperation and collaboration. Hart's (1992) collaborative framework informed the organisation of the classroom to create the conditions that supported collaboration amongst peers and the teacher.
An action research approach was used to reflect on the classroom context and provide a focus for a range of qualitative research methods. Multiple data sources such as teacher observations, interviews, student and teacher reflection logs and sociograms were used to triangulate findings from parents, students and teachers. A sociocultural perspective (Vygotsky, 1978) provided the conceptual framework for this study as the underlying assumption is that students learn from each other, mediated by the teacher or more capable peers. The focus on the action within the social context during the development of interpersonal relationships is a key feature of peer mediated learning, which complemented the processes chosen by the teacher researcher to elucidate how a safe, supportive and democratic classroom was created. Class meetings, group work and reflective practices were used to scaffold students' understandings of interpersonal relationships to promote a culture that was consistent with Australia's democratic traditions. Reflective practices in the classroom provided opportunities for new perspectives to be developed, as new knowledge and experiences were integrated with existing personal practical knowledge.
The major findings reflected the foci of student and teacher conversations about students' interpersonal skills and their ability to get along with each other. In the first phase of the study establishing positive 'relationships' based on trust, through teambuilding activities provided the impetus for the next phase of the study about 'leadership'. This phase continued for most of the study, and provided authentic opportunities for students to develop leadership skills, which permeated the last phase of the study about 'friendships'. Students established mutually beneficial relationships that broadened their views about discriminatory behaviours, friendship and leadership.
The major conclusions drawn from the study is that teachers play a significant role in mediating positive relationships amongst peers. Further, it was evident that the explicit teaching of core shared values (Curriculum Council, 1998) provided the foundations of productive and active citizenship during the process of creating the conditions for a safe, supportive and democratic classroom.