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Journal articles on the topic 'Robin Smith'

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Published: 20 February 2023

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1

El-Sharoud, Walid M. "Robin James Rowbury: 30th April 1937 – 11th July 2012." Science Progress 95, no. 3 (September 2012): 233–37. http://dx.doi.org/10.3184/003685012x13454664243724.

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Robin Rowbury, Life Sciences Editor of Science Progress since 1995, died in July 2012 following a long battle with cancer. Despite his illness he continued working right up until May this year both writing and promoting the journal wherever he could. In this issue, we are proud to feature his final article in which he describes the multi-talented character who was Robert Hooke. However, first we are publishing some tributes to Robin whom we remember in the office as a gentle man with a very dry sense of humour, as well as a hard-working author and editor. We shall all certainly miss him. Professor David Phillips CBE, FRSC who worked as Physical Sciences Editor alongside Robin describes him as a real gentleman and an excellent academic. Dr David Smith, his lifelong colleague from University College London remembers Robin as a supportive friend and colleague, a great teacher, and a gifted research scientist. He influenced many lives, and numerous students owe their successful careers to his guidance. These sentiment are reflected in three more tributes from former colleagues.

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Smith, Jeremy. "Freedom is a Point of Departure, Not a Horizon." Identities: Journal for Politics, Gender and Culture 19, no. 1-2 (December 2, 2022): 176–80. http://dx.doi.org/10.51151/identities.v19i1-2.496.

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The following is a review of the recently published translation of Theory of the Solitary Sailor by Gilles Grelet (trans. Amy Ireland and Robin Mackaye, Falmouth: Urbanomic, 2022). It highlights the significance of the work, its major stakes, and asks questions regarding the future of Grelet's methodical anti-philosophical invention. Author(s): Jeremy R. Smith Title (English): Freedom is a Point of Departure, Not a Horizon Journal Reference: Identities: Journal for Politics, Gender and Culture, Vol. 19, No. 1-2 (2022). Publisher: Institute of Social Sciences and Humanities - Skopje Page Range: 176-180 Page Count: 4 Citation (English): Jeremy R. Smith, "Freedom is a Point of Departure, Not a Horizon,” Identities: Journal for Politics, Gender and Culture, Vol. 19, No. 1-2 (2022): 176-80. Author Biography Jeremy R. Smith, Western University Jeremy R. Smith is a PhD Candidate at the Centre for the Study of Theory and Criticism at Western University. He is a co-founder and co-editor of Oraxiom: A Journal of Non-Philosophy.

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Omrani, Bijan. "Robin Brooke-Smith. Storm Warning: Riding the Crosswinds in the Pakistan-Afghan Borderlands." Asian Affairs 45, no. 2 (May 4, 2014): 361–63. http://dx.doi.org/10.1080/03068374.2014.911020.

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Punt, André E., David C. Smith, and Anthony D. M. Smith. "Among-stock comparisons for improving stock assessments of data-poor stocks: the “Robin Hood” approach." ICES Journal of Marine Science 68, no. 5 (May 1, 2011): 972–81. http://dx.doi.org/10.1093/icesjms/fsr039.

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Abstract Punt, A. E., Smith, D. C., and Smith, A. D. M. 2011. Among-stock comparisons for improving stock assessments of data-poor stocks: the “Robin Hood” approach. – ICES Journal of Marine Science, 68: 972–981. An approach is outlined for conducting stock assessments in which parameters are estimated for multiple stocks at the same time. Information from data-rich stock assessments, e.g. trends in fishing mortality, and values for parameters of selectivity functions are provided to data-poor assessments in the form of penalties on the estimated parameters, which leads to stock assessments for the most data-poor stocks being informed by those for the most data-rich stocks. The method is applied for example purposes to data for nine stocks in Australia's southern and eastern scalefish and shark fishery. The results of the application confirm that results for data-rich stocks are little impacted by being assessed in conjunction with data-poor stocks and that the results for data-poor stocks can be qualitatively different when information for data-rich stocks is taken into account.

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Glass, Bryan P. "The Amazing Armadillo: Geography of a Folk Critter. Larry L. Smith , Robin W. Doughty." Quarterly Review of Biology 60, no. 4 (December 1985): 522–23. http://dx.doi.org/10.1086/414644.

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Diwekar, Urmila M. "Chemical process design. By Robin Smith, McGraw-Hill, New York, 1995, 459 pp.,$65.00." AIChE Journal 42, no. 5 (May 1996): 1500. http://dx.doi.org/10.1002/aic.690420533.

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7

Prikazchikova, E. E. "MYTHOLOGICAL DISCOURSE OF THE ENGLISH SERIES ‟ROBIN FROM SHERWOOD” (1984–1986)." Siberian Philological Forum 20, no. 3 (September 30, 2022): 90–108. http://dx.doi.org/10.25146/2587-7844-2022-20-3-127.

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Statement of the problem. The article deals with the main mythological projections of the English series Robin of Sherwood, a cult mystical film of the 1980s dedicated to the legendary English robber Robin Hood. The purpose of the article is to holistically analyze the main mythological images and plots that are recreated over the course of three seasons of the series and form its ideological and compositional basis. The research methodology is determined by the traditions of mythopoetic analysis based on the studies of famous Western European mythologists (M. Oldhouse-Green, S. Knight, D. Campbell, B. Branston, P. Smith, S. Cox). As a result of the study, an interpretation is given to the images of Robin Hood and Herne the hunter, mythologems of human sacrifice, including the image of Kromm Cruach, the Wild Hunt. It is proved that the magical artifacts of the series are the Silver Arrow, the Albion sword, King Arthur’s Round Table, Sefer Yetzirah (Book of Creation), the main treatise of Jewish mysticism of the 2-6th centuries n. e., the “ring of nine maidens”, the genesis of which is associated with mythological ideas about the Celtic goddess Brigid and the Welsh goddess Arianrhod. The conclusions substantiate the reasons that made this series cult for the era of the 1980s. It is noted that many screen versions of the story of the English noble robber in the 21st century are directorial responses to the demands of their time.

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Kudra, Tadcusz. "Review of : “ Chemical Process Design” by Robin Smith McGraw-Hill, Inc. NY. 1995, 460 p." Drying Technology 15, no. 10 (November 1997): 2617–18. http://dx.doi.org/10.1080/07373939708917383.

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9

Andrews, Donald W. K., and Patrik Guggenberger. "ASYMPTOTIC SIZE OF KLEIBERGEN’S LM AND CONDITIONAL LR TESTS FOR MOMENT CONDITION MODELS." Econometric Theory 33, no. 5 (October 3, 2016): 1046–80. http://dx.doi.org/10.1017/s0266466616000347.

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An influential paper by Kleibergen (2005, Econometrica 73, 1103–1123) introduces Lagrange multiplier (LM) and conditional likelihood ratio-like (CLR) tests for nonlinear moment condition models. These procedures aim to have good size performance even when the parameters are unidentified or poorly identified. However, the asymptotic size and similarity (in a uniform sense) of these procedures have not been determined in the literature. This paper does so.This paper shows that the LM test has correct asymptotic size and is asymptotically similar for a suitably chosen parameter space of null distributions. It shows that the CLR tests also have these properties when the dimension p of the unknown parameter θ equals 1. When p ≥ 2, however, the asymptotic size properties are found to depend on how the conditioning statistic, upon which the CLR tests depend, is weighted. Two weighting methods have been suggested in the literature. The paper shows that the CLR tests are guaranteed to have correct asymptotic size when p ≥ 2 when the weighting is based on an estimator of the variance of the sample moments, i.e., moment-variance weighting, combined with the Robin and Smith (2000, Econometric Theory 16, 151–175) rank statistic. The paper also determines a formula for the asymptotic size of the CLR test when the weighting is based on an estimator of the variance of the sample Jacobian. However, the results of the paper do not guarantee correct asymptotic size when p ≥ 2 with the Jacobian-variance weighting, combined with the Robin and Smith (2000, Econometric Theory 16, 151–175) rank statistic, because two key sample quantities are not necessarily asymptotically independent under some identification scenarios.Analogous results for confidence sets are provided. Even for the special case of a linear instrumental variable regression model with two or more right-hand side endogenous variables, the results of the paper are new to the literature.

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Šnircová, Soňa. "Art, Depth and Affect in Winter: Metamodernist Contexts of Ali Smith's Novel." Studia Universitatis Babeș-Bolyai Philologia 66, no. 2 (March 30, 2021): 159–74. http://dx.doi.org/10.24193/subbphilo.2021.2.11.

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"Art, Depth and Affect in Winter: Metamodernist Contexts of Ali Smith's Novel. The paper discusses Ali Smith’s Winter through the prism of the theory of metamodernism. The novel can be related to the works of authors who reject the cynical sophistication of postmodernist art and appropriate its strategies to focus on authenticity, sincerity, and affect. Drawing on Robin van den Akker, Alison Gibbons, and Timotheus Vermeulen, who maintain that the metamodernist structure of feeling manifests through a mix of/or oscillation between pre-modernist, modernist and postmodernist tropes and devices, the author considers Ali Smith’s novel a mixture of postmodernist, modernist and romantic elements and explores how these elements function in the production of the metamodernist effect of her novel. Keywords: metamodernism, Ali Smith, Winter, art, depth, affect "

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11

Clark, Ron. "Conquering the Content: A Step-by-Step Guide to Web-based Course Development - By Robin M. Smith." Teaching Theology & Religion 12, no. 4 (October 2009): 386–87. http://dx.doi.org/10.1111/j.1467-9647.2009.00562.x.

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Hudson, Joanne, and Natalie C. Walker. "Metamotivational State Reversals during Matchplay Golf: An Idiographic Approach." Sport Psychologist 16, no. 2 (June 2002): 200–217. http://dx.doi.org/10.1123/tsp.16.2.200.

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Using a case study approach, this study examined reversals in metamotivational state during golf competition. Five male golfers competed in a round robin tournament. Following each match, golfers were individually interviewed using a modified Metamotivational State Coding Schedule (Potocky, Cook, & O’Connell, 1993). Content analysis techniques were used to identify metamotivational states, reversals in metamotivational state, and the factors affecting them. Individual differences in metamotivational state profiles were evident; for instance, the tournament winner demonstrated the most consistent profile across matches. Overall, however, players’ profiles demonstrated more similarities than differences. Most frequently cited metamotivational states were paratelic and telic conformity, and reversals were attributable to contingent event, satiation, and frustration factors. These results support reversal theory proposals (Smith & Apter, 1975) and its use as a framework for understanding psychological processes during competitive sport (Kerr, 1993).

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13

Milburn, Trudy. "Book review: Robin James Smith, Richard Fitzgerald, and William Housley (eds), On Sacks: Methodology, Materials, and Inspirations." Discourse Studies 23, no. 5 (October 2021): 690–92. http://dx.doi.org/10.1177/14614456211051179.

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14

Phillipson, Chris. "Book reviews : The Development of Welfare Services For Elderly People Robin Means and Randall Smith Croom Helm, 1985, 377pp." Critical Social Policy 5, no. 14 (September 1985): 116–17. http://dx.doi.org/10.1177/026101838500501414.

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15

MCCABE, LOUISE. "Robin Means, Sally Richards and Randall Smith (2008), Community Care. 4th edition. Basingstoke: Palgrave Macmillan. £22.99, pp. 328, pbk." Journal of Social Policy 38, no. 4 (October 2009): 716–17. http://dx.doi.org/10.1017/s0047279409990092.

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16

Arxiu, Revista. "Editorial." Arxiu d'Etnografia de Catalunya, no. 18 (December 18, 2018): 5. http://dx.doi.org/10.17345/aec18.5-6.

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Teniu a les mans el número 18 de la revista Arxiu d’Etnografia de Catalunya. En aquesta ocasió, a l’apartat «Articles» presentem quatre excel·lents treballs producte d’investigacions fetes pels nostres estudiants de màster i doctorat. A l’apartat «Col·laboracions» aquest cop tenim la possibilitat de gaudir dels articles escrits per Ángel Martínez Hernáez (URV), Jaume Franquesa (U. de Buffalo), José Ignacio Muro (URV), Mireia Campanera (URV) i Miquel Fernández (UAB). Finalment, a l’apartat «Ressenyes», el professor Giordano Bruno ressenya l’obra de Hanna Horáková, Andrea Boscoboinik i Robin Smith (eds.) Utopia and Neoliberalism: Ethnographies of Rural Spaces, i Josep Lluís Mateo Dieste ressenya l’obra que coordina el professor Jordi Moreras Palenzuela conjuntament amb Marta Alonso Cabré, Khalid Ghali, Alberto López Bargados i Ariadna Solé Arraràs titulada Diàspores i rituals. El cicle festiu dels musulmans de Catalunya. A «Notes de recerca» Elisa Alegra Agís i Natàlia Carceller Maicas expliquen el projecte Consumo de drogas y vulnerabilidades sociales en adolescentes, i Jordi Roca Girona (explica el projecte Multiculturalitat en el comerç de proximitat.

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17

Shera, Wes. "Book reviews : Means, Robin and Randall Smith (1994) Community Care: Policy and Practice. London: The Macmillan Press Ltd, 277 pp. (pbk." International Social Work 39, no. 1 (January 1996): 104–5. http://dx.doi.org/10.1177/002087289603900110.

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18

KITLV, Redactie. "Book Reviews." New West Indian Guide / Nieuwe West-Indische Gids 63, no. 3-4 (January 1, 1989): 237–55. http://dx.doi.org/10.1163/13822373-90002032.

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-Raymond T. Smith, John Gabriel Stedman, Narrative of a five years expedition against the revolted negroes of Surinam in Guiana on the Wild Coast of South-America from the year 1772 to the year 1777. Edited by Richard Price and Sally Price. Baltimore: The Johns Hopkins University Press, 1988. xcvii + 708 pp.-Richard Price, John Gabriel Stedman, Reize naar Surinamen, door den Capitein John Gabriel Stedman, met platen en kaarten, naar het Engelsch, Jos Fontaine (ed.) Zutphen: De Walburg Pers, 1987. 176 pp.-Robert L. Paquette, David Eltis, Economic growth and the ending of the transatlantic slave trade. New York and Oxford: Oxford University Press, 1987. xiii + 418 pp.-Robert L. Paquette, Robin Blackburn, The overthrow of colonial slavery, 1776-1848. London and New York: Verso, 1988. 560 pp.-Jack P. Greene, Selwyn H.H. Carrington, The British West Indies during the American revolution. The Netherlands: Foris Publications, 1988. 222 pp.-H. Hoetink, Angel G. Quintero Rivera, Patricios y plebeyos: burgueses, hacendados, artesanos y obreros. Las relaciones de clase en el Puerto Rico de cambio de siglo. Rio Piedras, P.R. Ediciones Huracán, 1988. 332 pp.

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19

Gutjahr, Paul. "Book Reviews: Royal Skousen and Robin Scott Jensen, eds., Revelations and Translations, Volume 3, Parts 1 and 2, The Joseph Smith Papers." Mormon Studies Review 4 (January 1, 2017): 163–67. http://dx.doi.org/10.18809/msr.2017.0118.

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20

Savina, Natalia. "A Review of Hana Horáková, Andrea Boscoboinik, Robin Smith (eds.), Utopia and Neoliberalism: Ethnographies of Rural Spaces. Berlin: Lit-Verlag, 2018, 256 pр." Antropologicheskij forum 17, no. 48 (2021): 252–66. http://dx.doi.org/10.31250/1815-8870-2021-17-48-252-266.

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The reviewed collection of articles constitutes an intriguing attempt to understand the modern processes taking place in rural areas in terms of their relationship with utopian ideas and positions of neoliberalism. Using field materials from Central and Eastern Europe and China, researchers demonstrate a wide range of scenarios and practices related to imagining the rural world and rural lifestyles emerging in the context of globalization, industrialization, information technology development, and neoliberal politics. The similarity of the authors' methodological approaches and the general theoretical framework ensure the structural and substantive integrity of the collection, which allows the reader to engage in discussions about economic, social, cultural and other changes that are characteristic of most modern rural areas.

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21

den Hond, Frank. "THE COMMERCIAL IMPACTS OF GREEN PRODUCT DEVELOPMENT by Mark T. Smith, Robin Roy and Stephen Potter, 1996. Open University, ii + 57pp, £20.00 (pbk)." Business Strategy and the Environment 7, no. 1 (February 1998): 51–52. http://dx.doi.org/10.1002/(sici)1099-0836(199802)7:1<51::aid-bse134>3.0.co;2-c.

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22

MacNicol, John. "Robin Means and Randall Smith, The Development of Welfare Services for Elderly People, Croom Helm, London, 1985, 379 pp. £ 17.95, ISBN 0 70993531 5." Ageing and Society 6, no. 2 (June 1986): 249–51. http://dx.doi.org/10.1017/s0144686x00005833.

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23

Belford, Robert E. "Conquering the Content: A Step-by-Step Guide to Online Course Design (Jossey-Bass Guides to Online Teaching and Learning) (by Robin M. Smith)." Journal of Chemical Education 86, no. 8 (August 2009): 926. http://dx.doi.org/10.1021/ed086p926.

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24

Barnes, Jonathan. "The Prior Analytics - Robin Smith (ed., tr.): Aristotle, Prior Analytics (Translated, with Introduction, Commentary, and Notes). Pp. xxxi + 262. Indianapolis: Hackett Publishing Company, 1989. $27.50." Classical Review 40, no. 2 (October 1990): 234–36. http://dx.doi.org/10.1017/s0009840x00253420.

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25

Purvis, Samantha. "English Prize Essay Happiness and Experimentalism: on H(a)ppy and The Lesser Bohemians." English: Journal of the English Association 69, no. 264 (2020): 1–24. http://dx.doi.org/10.1093/english/efz046.

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Abstract This essay contends that happiness offers an alternative point of entry into recent debates about the supposed ‘hybridity’ or ‘dialectic’ of realism and experimentalism in contemporary literature. Sarah Ahmed’s The Promise of Happiness suggests that happiness is a particularly contemporary concern; I will also argue that it has been brought surprisingly to the fore in two recent experimental texts, Eimear McBride’s The Lesser Bohemians1 and Nicola Barker’s H(A)PPY. At first glance, the marriage of experimentalism and happiness may appear odd; as Sianne Ngai observes, the avant-garde ‘is conventionally imagined as sharp and pointy, as hard- or cutting-edge’, and Rachel Greenwald Smith has delineated a supposed tension between affect and postmodernism. However, Claire Colebrook’s theory of a relationship between literature and non-teleological or desubjectivized happiness helps us to see how Barker and McBride mobilize the destabilizing capacities inhering in literary form to return a greater complexity and ambivalence to the concept of happiness. This suggests one way of placing the novels in terms of literary history and contemporary aesthetics, evoking what Timotheus Vermeulen and Robin van den Akker call a ‘metamodernist oscillation’ between postmodern suspicion and modernist hope. However, the erratic behaviour of happiness as narrative telos in the novels also challenges the logic of aesthetic categories by alerting us to the strangeness of literary form, suggesting that qualities normally attributed to experimental writing may be possibilities inhering in literature as such.

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26

Walmsley, J. "Community Care: Policy and Practice, 3rd edn, Robin Means, Sally Richards and Randall Smith, London, Palgrave Macmillan, 2003, pp. 265, ISBN 0 333 69349 3, 17.99." British Journal of Social Work 34, no. 5 (July 1, 2004): 760–61. http://dx.doi.org/10.1093/bjsw/bch097.

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27

Stephen, J. Drew. "Robin Elliott and Gordon E. Smith, eds. 2001. István Anhalt: Pathways and Memory. Montreal: McGill-Queen's University Press, xx, 425 pp. ISBN 0- 7735-2102-X (paperback)." Canadian University Music Review 24, no. 1 (2003): 131. http://dx.doi.org/10.7202/1014678ar.

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Cameron, C. "Alexander (Sandy) Wylie Logie Samuel Geoffrey Bedford Hilary Janet Davies George Gregor Donaldson Kenneth Charles Easton Benjamin Sidney Good Nicholas Hugh Gordon Emanuel Silver Robin Barker Smith." BMJ 322, no. 7290 (April 7, 2001): 867. http://dx.doi.org/10.1136/bmj.322.7290.867.

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Simonson, P. "Community Care, Policy and Practice, 4th edn, Robin Means, Sally Richards and Randall Smith, Basingstoke, Palgrave Macmillan, 2008, pp. vii+263, ISBN 978 0 230 00674 4, 21.99." British Journal of Social Work 38, no. 7 (October 1, 2008): 1454–55. http://dx.doi.org/10.1093/bjsw/bcn128.

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30

STRACHAN, HEW. "THE FIRST WORLD WAR." Historical Journal 43, no. 3 (September 2000): 889–903. http://dx.doi.org/10.1017/s0018246x99001399.

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The arming of Europe and the making of the First World War. By David G. Herrmann. Princeton: Princeton University Press, 1996. Pp. xiii+307. ISBN 0-691-03374-9. £29.50.Armaments and the coming of war: Europe 1904–1914. By David Stevenson. Oxford: Clarendon Press, 1996. Pp. xi+463. ISBN 0-19-820208-3. £48.00.Authority, identity and the social history of the Great War. Edited by Frans Coetzee and Marilyn Shevin-Coetzee. Providence and Oxford: Berghahn Books, 1995. Pp. xxii+362. ISBN 1-57181-017-X. £40.Dismembering the male: men's bodies, Britain and the Great War. By Joanna Bourke. London: Reaktion Books, 1996. Pp. 336. ISBN 0-948462825. £19.95.Passchendaele: the untold story. By Robin Prior and Trevor Wilson. New Haven and London: Yale University Press, 1996. Pp. xv+237. ISBN 0-300-066292-9. £19.95.Battle tactics of the western front: the British army's art of attack, 1916–1918. By Paddy Griffith. New Haven and London: Yale University Press, 1996 (paperback edition). Pp. xvi+286. ISBN 0-300-06663-5. No price given.Government and the armed forces in Britain, 1856–1990. Edited by Paul Smith. London, Hambledon Press, 1996. Pp. xviii+324. ISBN 1-85285-144-9. £35.Whether or not arms races cause wars was a historiographical preoccupation of the Cold War era. The issue was then of more than academic concern. Those opposed to the proliferation of nuclear weapons saw previous arms races as having destabilized the international system at best and as having led ineluctably to war at worst. Their critics countered that arms races possessed the capacity to increase terror and so promote more effective deterrence.

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31

Oliver, Mike. "Book Reviews : Community Care: policy and practice Robin Means and Randall Smith Macmillan, Basingstoke, 1994, £10.99 pbk, ISBN 0 3335 4932 5; £37.50 hbk ISBN 0 3335 4931 7." Critical Social Policy 15, no. 44-45 (October 1995): 240–42. http://dx.doi.org/10.1177/026101839501504420.

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Brown, Michael. "Ireland and the English World in the Late Middle Ages: Essays in Honour of Robin Frame. Edited by Brendan Smith. Pp. xii, 241. ISBN: 9780230542891. Basingstoke: Palgrave Macmillan, 2009. £50.00." Scottish Historical Review 89, no. 1 (April 2010): 101–2. http://dx.doi.org/10.3366/shr.2010.0007.

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33

Askham, Janet. "Randall Smith, Lucy Gaster, Lyn Harrison, Linda Martin, Robin Means and Peter Thistlethwaite, Working Together for Better Community Care, Bristol, School for Advanced Urban Studies, 1993, 242 pp., £11.95 paper." Journal of Social Policy 23, no. 1 (January 1994): 115–16. http://dx.doi.org/10.1017/s0047279400021425.

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34

Glowska, Eliza, Kamila Romanowska, Brian K. Schmidt, and Miroslawa Dabert. "Combined description (morphology with DNA barcode data) of a new quill mite Torotrogla paenae n. sp. (Acariformes: Syringophilidae) parasitising the Kalahari scrub-robin Cercotrichas paena (Smith) (Passeriformes: Muscicapidae) in Namibia." Systematic Parasitology 95, no. 8-9 (September 19, 2018): 863–69. http://dx.doi.org/10.1007/s11230-018-9815-z.

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35

Way, Michael. "Expression of Concern: Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria. Nataly Shulga, Robin Wilson-Smith, John G. Pastorino. J Cell Sci doi: 10.1242/jcs.061846." Journal of Cell Science 129, no. 4 (February 15, 2016): 868. http://dx.doi.org/10.1242/jcs.186999.

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Pauley, Bruce F. "Anton Pelinka. Austria: Out of the Shadow of the Past. Nations of the Modern World: Europe. ed. Smith Rand and Remington Robin. Boulder, Colo.: West-View Press, 1998. Pp. vi, 256, tables." Austrian History Yearbook 30 (January 1999): 316–17. http://dx.doi.org/10.1017/s0067237800016258.

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SCHARF, THOMAS. "Robin Means, Hazel Moreby and Randall Smith (2002), From Community Care to Market Care? The development of welfare services for older people, Bristol: Policy Press, ix + 201 pp., £45.00, £18.99 pbk., ISBN 1861342659." Journal of Social Policy 32, no. 1 (January 2003): 131–55. http://dx.doi.org/10.1017/s004727940232693x.

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Ketcham, John M., David M. Briere, Aaron C. Burns, James G. Christensen, Robin J. Gunn, Jacob Haling, Anthony Ivetac, et al. "Abstract LB505: Design and discovery of MRTX0902, a potent, selective, and orally bioavailable SOS1 inhibitor." Cancer Research 82, no. 12_Supplement (June 15, 2022): LB505. http://dx.doi.org/10.1158/1538-7445.am2022-lb505.

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Abstract KRAS mutations are the most common activating mutations in human cancer that ultimately lead to hyperactivation of the MAPK pathway and uncontrolled growth. KRAS functions as a small GTPase that cycles through its GTP-loaded “on” state and its GDP-loaded “off” state, a highly regulated process that is crucial for normal cell proliferation and survival. The guanine nucleotide exchange factor (GEF) SOS1 plays a critical role in this process by regulating the “on/off” state of KRAS. The protein-protein interaction between SOS1 and KRAS facilitates turnover of KRAS from the GDP-loaded inactive state to its activated and GTP-loaded state, a critical step to enable productive KRAS effector binding and activation of downstream signaling. The KRASG12C inhibitor, adagrasib (MRTX849), irreversibly binds to the GDP-loaded inactive conformation of KRASG12C and has recently shown encouraging clinical activity across several cancer types. As adagrasib binds preferentially to the inactive state of KRAS, blockade of SOS1 is anticipated to shift KRASG12C into the adagrasib-susceptible GDP-loaded state. Furthermore, this combination strategy could be used to target other mutant-driven cancers within the MAPK pathway using the appropriate KRASmut inhibitors and/or inhibitors of other targets within the MAPK pathway including MEK or EGFR. MRTX0902 was identified using iterative structure-based design as a selective inhibitor of SOS1 that demonstrates an IC50 value of 2 nM in a SOS1 HTRF binding assay and 30 nM in an MKN1 cellular assay. In pharmacokinetic evaluation across species, MRTX0902 demonstrated low extraction ratios and moderate to high bioavailability in mice, rats, and dogs. In preclinical models, MRTX0902 augmented the antitumor activity of adagrasib and other selected therapies. The design, discovery, and preclinical characterization of the potential best-in-class candidate MRTX0902 will be described. Citation Format: John M. Ketcham, David M. Briere, Aaron C. Burns, James G. Christensen, Robin J. Gunn, Jacob Haling, Anthony Ivetac, Shilpi Khare, Jon Kuehler, Svitlana Kulyk, Jade Laguer, John D. Lawson, Krystal Moya, Natalie Nguyen, Peter Olson, Lisa Rahbaek, Christopher R. Smith, Niranjan Sudhakar, Nicole C. Thomas, Darin Vanderpool, Xiaolun Wang, Matthew A. Marx. Design and discovery of MRTX0902, a potent, selective, and orally bioavailable SOS1 inhibitor [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB505.

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PENG, PING, DAYOU ZHAI, ROBIN J. SMITH, QIANWEI WANG, YUN GUO, and LIPING ZHU. "Erratum: PING PENG, DAYOU ZHAI, ROBIN J. SMITH, QIANWEI WANG, YUN GUO & LIPING ZHU (2021) On some modern Ostracoda (Crustacea) from the Tibetan Plateau in SW China, with descriptions of three new species. Zootaxa, 4942: 501–542." Zootaxa 4964, no. 3 (April 23, 2021): 599. http://dx.doi.org/10.11646/zootaxa.4964.3.11.

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Ketcham, John M., Shilpi Khare, Niranjan Sudhakar, David M. Briere, Larry Yan, Jade Laguer, Laura Vegar, et al. "Abstract ND02: MRTX0902: A SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers." Cancer Research 82, no. 12_Supplement (June 15, 2022): ND02. http://dx.doi.org/10.1158/1538-7445.am2022-nd02.

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Abstract KRAS is the most frequently mutated oncogene in cancer and drives uncontrolled growth through hyperactivation of the MAPK pathway. Significant progress has been made in the past several years to directly target KRASG12C with the FDA approval of sotorasib and the reported clinical activity of adagrasib (MRTX849). Despite these remarkable breakthroughs, additional therapies that enhance the depth and duration of response to KRASG12C inhibitors provide the opportunity to build upon the initial progress. SOS proteins are guanine nucleotide exchange factors (GEFs) that transduce receptor tyrosine kinase (RTK) signaling from the cell surface and facilitate the activation of RAS family proteins. In addition, SOS1 is a target of negative feedback signaling following RAS-mediated activation of the RAF-MEK-ERK cascade. Thus, SOS proteins represent a significant therapeutic node that maintains RAS pathway equilibrium as well as oncogenic signaling dynamics. Here we highlight the discovery and preclinical evaluation of MRTX0902, a potent, selective, and orally bioavailable inhibitor of SOS1 presently in IND-enabling studies. A structure-based approach was used to identify a novel chemical series that disrupts the protein-protein interaction between SOS1 and KRAS, thereby preventing SOS1-mediated GTP-exchange on GDP-bound KRAS. Considering MRTX849 preferentially binds to inactive GDP-bound KRASG12C, targeting SOS1 in this genetic context increases the ability of MRTX849 to bind and inhibit KRASG12C. The combination of MRTX0902 with MRTX849 enhances the depth and durability of an anti-tumor response when compared to MRTX849 alone in pre-clinical KRASG12C tumor models. MRTX0902 augments additional targeted therapies across a variety of RAS-addicted tumors, indicating that SOS1 inhibition is effective against a broad spectrum of mutations within the MAPK pathway. Furthermore, drug-anchored CRISPR experiments with MRTX0902 and MRTX849 uncovered a previously underappreciated functional role of the SOS1 paralog, SOS2, in KRAS-addicted tumors. In addition to aiding in the understanding of SOS and RAS family signaling dynamics, these studies implicate SOS2 as a potential cancer drug target in the context of SOS1/KRASG12C inhibition. In summary, we have used a structure-based approach to discover a SOS1 inhibitor that augments the anti-tumor activity of MRTX849 and additional targeted MAPK pathway inhibitors. We anticipate our findings to translate into the clinic and make an impact in patients with RAS-addicted tumors. Citation Format: John M. Ketcham, Shilpi Khare, Niranjan Sudhakar, David M. Briere, Larry Yan, Jade Laguer, Laura Vegar, Darin Vanderpool, Jill Hallin, Lauren Hargis, Vickie Bowcut, David Lawson, Robin J. Gunn, Anthony Ivetac, Nicole C. Thomas, Barbara Saechao, Natalie Nguyen, Jeffrey Clarine, Lisa Rahbaek, Christopher R. Smith, Aaron C. Burns, Matthew A. Marx, James G. Christensen, Peter Olson, Jacob R. Haling. MRTX0902: A SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr ND02.

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Bowcut, Vickie, Andrew Calinisan, David M. Briere, Lauren Hargis, Lars D. Engstrom, Jade Laguer, Darin Vanderpool, et al. "Abstract 1131: Pharmacogenomic insight into targetable vulnerabilities and modifiers of response to MRTX1133 in KRASG12D-mutant models." Cancer Research 82, no. 12_Supplement (June 15, 2022): 1131. http://dx.doi.org/10.1158/1538-7445.am2022-1131.

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Abstract The ability to effectively target mutated KRAS has remained elusive despite decades of research. Recently, the identification of selective KRASG12C inhibitors has provided an effective treatment option for patients harboring this particular mutation and has also provided insight toward targeting other KRAS mutants, including KRASG12D. MRTX1133 was identified via a structure-based drug design strategy as a potent, selective, and non-covalent KRASG12D inhibitor directed at the switch II binding pocket. MRTX1133 exhibited dose dependent KRAS pathway and tumor growth inhibition and demonstrated marked anti-tumor activity across a panel of models in vivo, including tumor regression >30% in 8 out of 11 pancreatic ductal adenocarcinoma (PDAC) models. While evaluation of MRTX1133 across a panel of cell and patient-derived xenograft models demonstrated strong single agent activity in the majority of models tested, a subset of models were less responsive. Focused sgRNA libraries targeting ~5,000 genes were tested in MRTX1133-anchored CRISPR/Cas9 screens in vitro and in vivo in PDAC and colorectal KRASG12D-mutant cell lines. Similar to what was seen in a targeted genetic screen with our selective KRASG12C inhibitor MRTX849, several genes that act either upstream or downstream of KRAS were depleted with MRTX1133 treatment which illuminate specific targetable vulnerabilities in the context of KRASG12D inhibition. sgRNAs targeting EGFR, PIK3CA, PTPN11, mTOR, and CDK2/4/6 were depleted in MRTX1133-treated (or vehicle-treated) cell lines or xenograft models, while hallmark tumor suppressor genes RB1, KEAP1, NF1 and PTEN were enriched. The enrichment of KEAP1 sgRNAs in PDAC models parallels findings with MRTX849 in preclinical models and is in line with emerging clinical data suggesting increased capacity to scavenge reactive oxygen species (ROS) may represent a mechanism of partial resistance to a non-covalent, non-electrophilic warhead-containing KRASG12D-selective inhibitor in PDAC. Treatment using small molecules targeting selected vulnerabilities in vitro and in vivo confirmed these genetic findings. Further evaluation of dependencies utilizing an integrated analysis of RNAseq data also revealed KRAS regulates and is critically dependent on pro-survival and cell cycle genes for cancer cell viability. These data lend further insight into tumor response to KRASG12D inhibition and provide key insight into the genes that mediate the mechanism of action of, as well as confer partial resistance to MRTX1133, and identify combination targets that can augment the anti-tumor effect of MRTX1133. Citation Format: Vickie Bowcut, Andrew Calinisan, David M. Briere, Lauren Hargis, Lars D. Engstrom, Jade Laguer, Darin Vanderpool, Xiaolun Wang, J David Lawson, Nicole Thomas, Robin Gunn, Christopher R. Smith, Julio Fernandez-Banet, Leo He, Adam Pavlicek, Lisa Rahbaek, Matthew A. Marx, Peter Olson, James G. Christensen, Jill Hallin. Pharmacogenomic insight into targetable vulnerabilities and modifiers of response to MRTX1133 in KRASG12D-mutant models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1131.

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Омельченко, Г. Ю., and О. М. Осіпов. "ОНТОЛОГІЯ КОМУНІКАТИВНОЇ РЕАЛЬНОСТІ." Humanities journal, no. 2 (October 29, 2018): 13–18. http://dx.doi.org/10.32620/gch.2018.2.02.

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The authors consider the problem of communication as social reality in the context of conceptual representations of non-classical ontology. These views are based on the idea of variability in the interpretation of basic philosophical category of reality. Works of Chris Berry, Jean Baudrillard, Robin Dunbar, Paul Lazarsfeld, Harold Laswell, Andrew Zverintsev, Charles Cooley, Merab Mamardashvili, Alina Panfilova, Alan Pulford, Paul Smith, Arkady Ursuland and others are devoted to this problem.The article aims to clarify the ontological meaning of the concept «communicative reality». It can resolve conceptual representations of non-classical ontology that is based on the idea of variability of interpretation basic to the concept of space is a philosophical category of reality.Non-classical ontology interprets the concept of «reality» as a collection of objects and phenomena that have approximately the same being or exist in the same way. If being is the property of objects, and existence is their procedural characteristics, then reality is the very objects that possess this property and realize this action. Thus, the objects and phenomena of the material world exist in one way and form an objective reality. There is another way and form of artistic reality. Plans, projects, fantasies have a way of existence and form of mental reality. Therefore, there is an idea of coexistence of different realities. Thus, it is possible to consider not only one reality («actually existed»), but also different realities that constitute the «sector of existence». In this case, it is necessary to speak not about reality, but about reality in a particular sector of life (objective, subjective and virtual reality). That is, the communicative reality can be defined as the particular sector being associated with a subjective interpretation of the real world. Is it possible to define a specific combination of objects, existing solely in the communication processes according to the laws that differ from laws of objective and virtual reality?Therefore, social communication is the result of the interaction of objectively existing segments of the social structure, with defined interests and requests. Social communication is based on existing channels of social ties and actually existing social interests and preferences. It is established that the person prefers to obtain information from a limited number of sources, which he/ she considers asthe closest social environment. Information is perceived positively if it meets social needs of individuals. Information influence that does not consider requests and exceeds the threshold of perception is filtered out as information noise. The patterns of perception of information determine certain forms of informational influence.Thus, the communicative reality even when generating a virtual picture of the world relies on objectively existing social relations, patterns of perception of information and the channels of mass communication. To sum up, the authorsgive an ontological definition of communication space– a set of conditions of interaction of social facilities, with a focus on specific layers of links between the communication objects.

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Berg, Ian. "PSYCHIATRY SELECTIONJournal of the American Academy of Child and Adolescent Psychiatry (1998–1999) J. Max, S. Koele, W. Smith, Y. Sato, S. Lindgren, D. Robin, & S. Arndt. Psychiatric disorders in children and adolescents after severe traumatic brain injury: A controlled study. Vol. 37, pp. 832–840." Child Psychology and Psychiatry Review 5, no. 1 (February 2000): 44–45. http://dx.doi.org/10.1017/s1360641799229565.

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Bissell, L. A., D. Furst, S. Johnson, P. Hansen, E. Recalde, D. Khanna, and F. Del Galdo. "POS0868 THE DEVELOPMENT OF THE LINEAR CRISS; A CLINICAL AND PATIENT MEANINGFUL ANCHOR TO THE ACR-CRISS IN SCLERODERMA." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 728. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1896.

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BackgroundThe ACR Composite Response Index in Systemic Sclerosis (ACR-CRISS) is one of the first composite outcome measures in diffuse cutaneous Systemic sclerosis (dcSSc).1 It relies on validated clinical domains selected through a data-driven methodology; however, it only provides a probability of response and is unable to differentiate between patients who do not improve and who worsen respectively.ObjectivesTo improve the clinical interpretation of the ACR-CRISS by creating a continuous ranked score of clinically and patient meaningful changes of its individual measures.MethodsFollowing OmerACT guidelines for outcome measurement development, relevant stakeholders were identified from 5 continents, including 100 physicians with proven experience in managing patients with dcSSc and 100 patients with dcSSc who have participated in at least one clinical trial. An adaptive conjoint analysis survey based on the PAPRIKA method2 and implemented using 1000minds software was administered. Patients and doctors were asked to choose which of two hypothetical patients had a better or worse outcome according to Minimally Clinical Important Differences (MCID) in two domains at a time from FVC, HAQ-DI and mRSS and the presence of organ failure. These pairwise choices were analysed to rank and weight the MCIDs against each other. With patient and public involvement, utilising a ‘think aloud’ approach, a video tutorial was produced explaining the objectives and process of the adaptive survey to the participants.ResultsEighty rheumatologists and 80 patients with dcSSc completed the survey, which ran from June 2020 to January 2021. From the survey, relative weights for the 4 domains, reflecting their relative importance with respect to improving and worsening outcomes, were determined. A continuous composite ranked score reflecting the relative weighting of the individual outcome measures (Ranked Composite Important Difference, RCID) was developed accordingly (Table 1). The score ranges from -1 (worst possible outcome) to 1 (best possible outcome), in patients who experience no organ failure and do not meet any MCID in any of the 3 domains scoring 0.Table 1.The relative median weights of each of the core set measures within the better and worse outcome models, expressed as a score from -1 to 1Worsening weightsImprovement weightsDoctorsPatientsCombinedDoctorsPatientsCombinedOrgan failure-0.355-0.333-0.326N/AN/AN/AFVC-0.324-0.306-0.3160.4630.4520.451mRSS-0.205-0.229-0.2170.3200.3200.324HAQ-DI-0.114-0.115-0.1410.2000.2270.224ConclusionThis collaborative process using a novel, robust methodology and involving both rheumatologists and patients has created a clinically and patient meaningful composite score that can be used as an anchor to the ACR-CRISS, or other clinical outcomes. Performance against the ACR-CRISS and revised CRISS in randomised controlled trials and in observational cohorts will determine the clinical value of the RCID.References[1]Khanna D, et al. A&R 2016;68:299–311[2]Hansen P, Ombler F. Multi-Criteria Decis. Anal 2008;15:87–107AcknowledgementsDK and FDG are recognised as joint senior authors. The authors acknowledge the doctors and patients involved in the Linear Criss working group: Giuseppina Abignano, Paolo Airò, Dina-Marie Aiuto, Yannick Allanore, Shervin Assassi, Jérôme Avouac, Gianluca Bagnato, Alexandra Balbir-Gurman, Silvia Bellando Randone,Lorenzo Beretta, Elana Bernstein, Silvia Laura Bosello, Yolanda Braun Moscovici, Katrina Brown, Maya Buch, Corrado Campochiaro, Patricia Carreira, Lorinda Chung, Julia Coakes, Mary Cox, Giovanna Cuomo, Maurizio Cutolo, Laszlo Czirjak, Lorenzo Dagna, Giacomo De Luca, Nicoletta Del Papa, Christopher Denton, Emma Derrett-Smith, Robyn Domsic, Raluca-Bianca Dumitru, Victoria Flower, Ivan Foeldvari, Armando Gabrielli, Yasir Ghaffar, Roberto Giacomelli, Dilia Giuggioli, Daisy Gonzalez, Jessica Gordon, Yvonne Gouldstone, Marie Hudson, Francesca Ingegnoli, Lorraine Jackson, Sergio Jimenez, Terrance Johnson, Bashar Kahaleh, Robin King, Otylia Kowal-Bielecka, Masataka Kuwana, Maria Lazzaroni, Alain Lescoat, Takashi Matsushita, Marco Matucci Cerinic, Maureen Mayes, Thomas Medsger, Francesca Menegazzi, Tünde Minier, Mandana Nikpour, Chris O’Hora, Emese Paári-Molnár, John Pauling, Jose Antonio Pereira da Silva, Mercè Piñero Vegas, Janet Pope, Susanna Proudman, Ismaila Rafiq, Valeria Riccieri, Tatiana Sofia Rodriguez-Reyna, Tânia Santiago, James Seibold, Richard Silver, Robert Spiera, Tracy Stafford, Virginia Steen, Yossra Atef Suliman. Madelon Vonk, Ian Wright.Disclosure of InterestsLesley-Anne Bissell Speakers bureau: UCB, Abbvie, Galapagos, Daniel Furst: None declared, Sindhu Johnson: None declared, Paul Hansen: None declared, Esmeralda Recalde: None declared, Dinesh Khanna: None declared, Francesco Del Galdo Speakers bureau: Abbvie, AstraZeneca, Boehringer-Ingelheim, Capella Biosciences, Chemomab LTD, Janssen, Kymab LTD, Mitsubishi-Tanabe., Consultant of: Abbvie, AstraZeneca, Boehringer-Ingelheim, Capella Biosciences, Chemomab LTD, Janssen, Kymab LTD, Mitsubishi-Tanabe., Grant/research support from: Abbvie, AstraZeneca, Boehringer-Ingelheim, Capella Biosciences, Chemomab LTD, Janssen, Kymab LTD, Mitsubishi-Tanabe.

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Izadi, Selma, and Abdullah Noman. "Absence of the weekend effect and industry-style portfolios." Journal of Financial Economic Policy 12, no. 4 (November 29, 2019): 463–75. http://dx.doi.org/10.1108/jfep-04-2019-0066.

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Purpose The existence of the weekend effect has been reported from the 1950s to 1970s in the US stock markets. Recently, Robins and Smith (2016, Critical Finance Review, 5: 417-424) have argued that the weekend effect has disappeared after 1975. Using data on the market portfolio, they document existence of structural break before 1975 and absence of any weekend effects after that date. The purpose of this study is to contribute some new empirical evidences on the weekend effect for the industry-style portfolios in the US stock market using data over 90 years. Design/methodology/approach The authors re-examine persistence or reversal of the weekend effect in the industry portfolios consisting of The New York Stock Exchange (NYSE), The American Stock Exchange (AMEX) and The National Association of Securities Dealers Automated Quotations exchange (NASDAQ) stocks using daily returns from 1926 to 2017. Our results confirm varying dates for structural breaks across industrial portfolios. Findings As for the existence of weekend effects, the authors get mixed results for different portfolios. However, the overall findings provide broad support for the absence of weekend effects in most of the industrial portfolios as reported in Robins and Smith (2016). In addition, structural breaks for other weekdays and days of the week effects for other days have also been documented in the paper. Originality/value As far as the authors are aware, this paper is the first research that analyzes weekend effect for the industry-style portfolios in the US stock market using data over 90 years.

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Pelayo, P. "Reply to Comments from P. M. Smith and M. J. Price - Physiological Effects of Variations in Spontaneously Chosen Crank Rate During Submaximal and Supramaximal Upper Body Exercise. Re: Marais G, Weissland T, Robin H, Vanvelcenaher JM, Lavoie JM, Pelayo P. Int J Sports Med 1999; 19: 239 - 245 -." International Journal of Sports Medicine 21, no. 7 (October 2000): 542–43. http://dx.doi.org/10.1055/s-2000-7424.

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Jones, Bill, and Lynton Robins. "For the Guidance of Martians: A Reply to Martin Smith on British Politics Textbooks." Politics 20, no. 2 (May 2000): 105–9. http://dx.doi.org/10.1111/1467-9256.00119.

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A recent review article in the British Journal of Politics and International Relations made a number of criticisms about the supposed lack of innovation and theoretical rigour found in current British politics textbooks. Jones and Robins constructively engage the points made in the article and argue that the criticisms made are only partly valid. They conclude that, within the obvious confines of a basic text, there is more on offer to students than there has ever been and that the success of these textbooks provides publishers with the means to cross-subsidise minority interest scholarship.

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Egan, A., P. Sivasothy, R. Gore, M. Martinez Del-Pero, C. Owen, L. Willcocks, R. Smith, S. Burns, and D. Jayne. "AB0470 EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA) - ONE-YEAR FOLLOW-UP STUDY USING MEPOLIZUMAB ANTI-IL5 THERAPY AS A STEROID SPARING THERAPEUTIC APPROACH." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1533–34. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6555.

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Background:EGPA is a small vessel vasculitis characterised by the presence of tissue eosinophilia, necrotising vasculitis and granulomatous inflammation1. Typically, a prodromal asthmatic phase, leads to an eosinophilic stage, which can evolve to include the presence of vasculitis with renal manifestations. In the recent randomised, placebo-controlled MIRRA trial for relapsing and refractory EGPA, adjuvant therapy with anti-IL5 mAB Mepolizumab [MEPO] at 300mg s/c monthly, accrued longer times in remission, reduced steroid exposure and reduced relapse rates2.Objectives:The aim of our study was to analyse the response and outcome for EGPA patients who received 100mg s/c of MEPO monthly for a minimum of 52 weeks, with particular focus on the steroid minimisation benefits.Methods:This retrospective, descriptive study analysed 13 patients with EGPA, who received 100mg s/m monthly MEPO therapy under the eosinophilic asthma care-pathway. Time points of assessment included MEPO commencement [M0] and 12 [M12] months.Results:Table 1.EGPA patients receiving Mepolizumab therapy for one year [100mg s/c]DemographicsAll [n=13]Gender ratio M/F4M:9FANCA positive/ negativeANCA: 3MPO, 1 PR3 positive/ 9 ANCA negativeAge of diagnosis of asthma35 yrs [IQR 28.5-40]Age of diagnosis of EGPA47 yrs [IQR 43.5-53.5]Median age51 yrs [IQR 47.5- 60.5]EGPA disease characteristicsN=13 [%]Asthma 13 [100]Serum eosinophilia or biopsy evidence [N= 12] 12 [100]Pulmonary infiltrates, non-fixed 8[61.5]Neuropathy, mono/poly 4[30.7]Sino-nasal abnormality 12[92.3]Glomerulonephritis 3[23]Cardiovascular 4[30.7]Prior ImmunosuppressantsN=13 [%]Steroids13[100%]Cyclophosphamide 6[46%]Rituximab6[46%]Azathioprine10[77%]Mycophenolate mofetil8[62%]Methotrexate4[31%]Campath 1[7%]Response to therapyM0 [%] Post M12 [%]Prednisolone dose N= 13Mean ±SD 18.925 mg ±11.44 10.575mg ± 5.85Eosinophil count X109/L N=13Mean ±SD 0.415mg ±0.25 0.035±0.039Asthma Control Questionnaire [ACQ] N=5Mean ±SD 2.92 ±1.27 1.31± 0.79BVAS N= 13Mean ±SD 7.307±6.29 2.2307±1.69Creatinine N=9Mean ±SD 68.44±15.03 69.11±17.84Continuation of anti-IL5 therapy N=13 12/13 [92.3%]Conclusion:The relapsing nature of EGPA places a potential dependency of therapy on steroids for asthmatic and vasculitic flares. This underscores the importance of targeted pathway specific biologic therapy to minimise steroid exposure, prevent tissue damage and ensure early response to therapy. This study demonstrates that anti-IL5 serves as a favourable model with steroid minimisation, improvement in asthma control questionnaire, reduction in BVAS and eosinophil counts at the 100mg s/c dosage. ANCA positive serology normalised in all four patients, independent of subtype. Well tolerated, it demonstrated considerable clinical benefit, with 12 patients [92.3%] continuing anti-IL5 therapy beyond 12 months.Long term plan > 12 monthsN=13 [%] Current Months Adjuvant therapy 12M1 Continue15 Aza2 Switched Benralizumab 26 MMF [+], IVIG [-]3 Continue 184 Switched Benralizumab 145 Discontinued Rituximab 12 MTX6 Continue 147 Continue 24 MMF Reduced8 Continue 18 MTX [+]9 Continue 15 MMF [-]10 Continue 1411 Continue 1312 Continue 13 Aza13 Continue 12References:[1]J.C.Jenette,et alRevised International Chapel Hil Consensus Conference Nomenclature of Vasculitides.65, 1–11 (2013).[2]Wechsler, M. E.et al.Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis.N. Engl. J. Med.376, 1921–1932 (2017).Disclosure of Interests:Allyson Egan: None declared, pasupathy Sivasothy: None declared, Robin Gore: None declared, Marcos Martinez Del-Pero: None declared, Caroline Owen: None declared, Lisa Willcocks: None declared, Rona Smith: None declared, Stella Burns: None declared, David Jayne Grant/research support from: ChemoCentryx, GSK, Roche/Genentech, Sanofi-Genzyme, Consultant of: Astra-Zeneca, ChemoCentryx, GSK, InflaRx, Takeda, Insmed, Chugai, Boehringer-Ingelheim

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Swinnen, T. W., M. Willems, I. Jonkers, F. P. Luyten, J. Vanrenterghem, and S. Verschueren. "AB0602 IMPACT OF SOCIOECONOMIC FACTORS ON PAIN AND FUNCTION IN KNEE OSTEOARTHRITIS: A SYSTEMATIC LITERATURE REVIEW." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1337.2–1337. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3634.

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Background:The personal and societal burden of knee osteoarthritis (KOA) urges the research community to identify factors that predict its onset and progression. A mechanistic understanding of disease is currently lacking but needed to develop targeted interventions. Traditionally, risk factors for KOA are termed ‘local’ to the joint or ‘systemic’ referring to whole-body systems. There are however clear indications in the scientific literature that contextual factors such as socioeconomic position merit further scientific scrutiny, in order to justify a more biopsychosocial view on risk factors in KOA.Objectives:The aims of this systematic literature review were to assess the inclusion of socioeconomic factors in KOA research and to identify the impact of socioeconomic factors on pain and function in KOA.Methods:Major bibliographic databases, namely Medline, Embase, CINAHL, Web of Science and Cochrane, were independently screened by two reviewers (plus one to resolve conflicts) to identify research articles dealing with socioeconomic factors in the KOA population without arthroplasty. Included studies had to quantify the relationship between socioeconomic factors and pain or function. Main exclusion criteria were: a qualitative design, subject age below 16 years and articles not written in English or Dutch. Methodological quality was assessed via the Cochrane risk of bias tools for randomized (ROB-II) and non-randomized intervention studies (ROBIN-I) and the Newcastle-Ottawa Scale for assessing the quality of non-randomised studies. Due to heterogeneity of studies with respect to outcomes assessed and analyses performed, no meta-analysis was performed.Results:Following de-duplication, 7639 articles were available for screening (120 conflicts resolved without a third reader). In 4112 articles, the KOA population was confirmed. 1906 (25%) were excluded because of knee arthroplasty and 1621 (21%) because of other issues related to the population definition. Socioeconomic factors could not be identified in 4058 (53%) papers and were adjusted for in 211 (3%) articles. In the remaining papers covering pain (n=110) and/or function (n=81), education (62%) and race (37%) were most frequently assessed as socioeconomic factors. A huge variety of mainly dichotomous or ordinal socioeconomic outcomes was found without further methodological justification nor sensitivity analysis to unravel the impact of selected categories. Although the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was the most popular instrument to assess pain and function, data pooling was not possible as socioeconomic factors estimates were part of multilevel models in most studies. Overall results showed that lower education and African American race were consistent predictors of pain and poor function, but those effects diminished or disappeared when psychological aspects (e.g. discrimination) or poverty estimates were taken into account. When function was assessed using self-reported outcomes, the impact of socioeconomic factors was more clear versus performance-based instruments. Quality of research was low to moderate and the moderating or mediating impact of socioeconomic factors on intervention effects in KOA is understudied.Conclusion:Research on contextual socioeconomic factors in KOA is insufficiently addressed and their assessment is highly variable methodologically. Following this systematic literature review, we can highlight the importance of implementing a standardised and feasible set of socioeconomic outcomes in KOA trials1, as well as the importance of public availability of research databases including these factors. Future research should prioritise the underlying mechanisms in the effect of especially education and race on pain and function and assess its impact on intervention effects to fuel novel (non-)pharmacological approaches in KOA.References:[1]Smith TO et al. The OMERACT-OARSI Core Domain Set for Measurement in Clinical Trials of Hip and/or Knee Osteoarthritis J Rheumatol 2019. 46:981–9.Disclosure of Interests:None declared.

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Schubel, Laura C., Mandi L. Pratt-Chapman, Teletia Taylor, Robin A. Littlejohn, Andrea J. Lopez, Judith Lee Smith, Susan Sabatino, et al. "Abstract B031: Preferences for social risk factor screening among breast and prostate cancer survivors in the Washington DC region: A qualitative study." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (January 1, 2023): B031. http://dx.doi.org/10.1158/1538-7755.disp22-b031.

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Abstract:

Abstract Despite improvements in cancer outcomes over time, significant disparities remain between Black and White cancer survivors. Medical care is estimated to account for 10-20% of health outcomes, while other modifiable factors explain as much as 80-90% of outcomes. These disparities may thus be driven by multiple factors including social determinants of health, differences in treatment or follow up, or attitudes and behaviors of care teams. As part of a larger project, we conducted a qualitative study to understand cancer survivor preferences for and experiences with social needs screening and referrals. The results of this assessment will inform the delivery of social risk screening for breast and prostate cancer survivors in the multi-site study. Semi-structured interviews were conducted in English between March and April 2022 with breast and prostate cancer survivors from two cancer institutes in Washington DC. Patients were purposively recruited to ensure diversity in age, race, and cancer stage (I-III). Each interview lasted 60 minutes. Transcripts were reviewed for consensus and preferences for social needs screening. Thirteen survivors participated in the interviews. Participants were mostly breast cancer survivors (n=10), African American (n=6), were equal in stages I and II at time of diagnosis (n=5), and ranged in age from 34 to 81 with a median age of 64. Most patients (n=7) did not report social needs screening during their treatment, though all patients welcomed having these conversations with their care team. The majority of patients (n=9) desired face-to-face conversations as opposed to on paper (n=1) or through the patient portal (n=1). Similarly, most patients (n=7) did not mind who on their care team held the conversations. There was difference in opinion on how often social needs should be discussed, with four participants suggesting every appointment to another patient suggesting once at diagnosis. When asked about the needs patients experienced during treatment, food insecurity and nutrition were most cited (n=6), followed by transportation (n=4) and emotional resources (n=4). Only one patient reported not desiring social needs referrals during treatment. Other avenues for seeking out social resources included self-initiated research online or through books (n=2), and another patient described utilizing their local church (n=1). Finally, patients also spoke about challenges in receiving treatment and transitioning to survivorship due to the COVID-19 pandemic, including hospital staff turnover and care team inconsistency (n=1), bringing loved ones to appointments (n=1), and transportation challenges for individuals who relied on public transport to and from the clinic (n=1). This research reveals important insight to the perspective on social needs screening among a group of breast and prostate cancer survivors in the Washington DC region and highlights the ways in which patients have experienced and desire screening for social needs. In future work we will expand the number of interviews and apply these findings into practice. Citation Format: Laura C. Schubel, Mandi L. Pratt-Chapman, Teletia Taylor, Robin A. Littlejohn, Andrea J. Lopez, Judith Lee Smith, Susan Sabatino, Arica White, Joseph Astorino, Bryan O. Buckley, Christopher King, Hannah Arem. Preferences for social risk factor screening among breast and prostate cancer survivors in the Washington DC region: A qualitative study [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B031.

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