Academic literature on the topic 'RNAi pathway'
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Journal articles on the topic "RNAi pathway"
Dzianott, Aleksandra, Joanna Sztuba-Solińska, and Jozef J. Bujarski. "Mutations in the Antiviral RNAi Defense Pathway Modify Brome mosaic virus RNA Recombinant Profiles." Molecular Plant-Microbe Interactions® 25, no. 1 (January 2012): 97–106. http://dx.doi.org/10.1094/mpmi-05-11-0137.
Full textYang, Li, Yuan Tian, Yuan-Yuan Peng, Jinzhi Niu, and Jin-Jun Wang. "Expression Dynamics of Core RNAi Machinery Genes in Pea Aphids Upon Exposure to Artificially Synthesized dsRNA and miRNAs." Insects 11, no. 2 (January 21, 2020): 70. http://dx.doi.org/10.3390/insects11020070.
Full textSoleimani, Saeed, Zahra Valizadeh Arshad, Sharif Moradi, Ali Ahmadi, Seyed Javad Davarpanah, and Sadegh Azimzadeh Jamalkandi. "Small regulatory noncoding RNAs in Drosophila melanogaster: biogenesis and biological functions." Briefings in Functional Genomics 19, no. 4 (March 27, 2020): 309–23. http://dx.doi.org/10.1093/bfgp/elaa005.
Full textLew, A. E., L. A. Jackson, and M. I. Bellgard. "Comparative genomic analysis of non-coding sequences and the application of RNA interference tools for bovine functional genomics." Australian Journal of Experimental Agriculture 45, no. 8 (2005): 995. http://dx.doi.org/10.1071/ea05057.
Full textZhuang, Jimmy J., and Craig P. Hunter. "The Influence of Competition Among C. elegans Small RNA Pathways on Development." Genes 3, no. 4 (October 19, 2012): 671–85. http://dx.doi.org/10.3390/genes3040671.
Full textSzachnowski, Ugo, Sara Andus, Dominika Foretek, Antonin Morillon, and Maxime Wery. "Endogenous RNAi pathway evolutionarily shapes the destiny of the antisense lncRNAs transcriptome." Life Science Alliance 2, no. 5 (August 28, 2019): e201900407. http://dx.doi.org/10.26508/lsa.201900407.
Full textMondal, Mosharrof, Judith K. Brown, and Alex Flynt. "Exploiting somatic piRNAs in Bemisia tabaci enables novel gene silencing through RNA feeding." Life Science Alliance 3, no. 10 (August 6, 2020): e202000731. http://dx.doi.org/10.26508/lsa.202000731.
Full textCánovas-Márquez, José Tomás, Sebastian Falk, Francisco E. Nicolás, Subramanian Padmanabhan, Rubén Zapata-Pérez, Álvaro Sánchez-Ferrer, Eusebio Navarro, and Victoriano Garre. "A ribonuclease III involved in virulence of Mucorales fungi has evolved to cut exclusively single-stranded RNA." Nucleic Acids Research 49, no. 9 (April 20, 2021): 5294–307. http://dx.doi.org/10.1093/nar/gkab238.
Full textHolding, Cathy. "RNAi dissects signal pathway." Genome Biology 5 (2004): spotlight—20040624–01. http://dx.doi.org/10.1186/gb-spotlight-20040624-01.
Full textLucentini, Jack. "Second RNAi pathway emerges." Genome Biology 5 (2004): spotlight—20040517–01. http://dx.doi.org/10.1186/gb-spotlight-20040817-01.
Full textDissertations / Theses on the topic "RNAi pathway"
Yu, Yi-Hsin Biotechnology & Biomolecular Sciences Faculty of Science UNSW. "Role of the RNAi pathway in influenza a virus infected mammalian cells." Publisher:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/41545.
Full textAitken, Amelia. "Blocking the RNA Interference Pathway Improves Oncolytic Virus Therapy." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36821.
Full textAlagia, Adele. "Modulation of the RNAi pathway by chemically modified siRNA molecules." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/379307.
Full textPara dirigir el silenciamiento génico post-transcripcional, la maquinaria de RNAi explota la formación de pares de bases entre la hebra guía cargado y el ARNm complementario. La proteína Ago2 (Argonauta 2) es la "máquina de cortar" del complejo RISC y dirige la rotura endonucleolítica sólo cuando la hebra guía del siRNA está completamente apareada con su homóloga de ARN. Ago2 es capaz de incorporar una molécula de dúplex de siRNA, desenrolla la doble hélice y mantiene una hebra mientras se descarta la otra cadena. Ago2 cargada con la hebra guía se define "activa" y puede guiar múltiples reacciones de escisión contra los ARNm complementarios. El análisis estructural del proceso de ensamblaje de Ago2 ha llevado a la conclusión de que las primeras interacciones entre el siRNA y la proteina Ago2 se basa en el reconocimiento específico por el dominio PAZ. Por lo tanto, el correcto reconocimiento de dominio PAZ contribuye a la incorporación específica y productiva de los siRNAs en el Ago2. La hebra guía con su extremo 3' protuberante que tiene 2-nt está implicada en la mayoría de los contactos entre la cavidad presente en el dominio PAZ. En principio, las modificaciones en los extremos protuberantes se introdujeron para proteger la integridad del dúplex de ARN. Sólo después de la comprensión de la arquitectura de Ago2, se pensó en la utilización de las modificaciones en los extremos protuberantes para mejorar la potencia y especificidad de los siRNAs. Para explorar las características estructurales críticas para la interacción entre la cavidad PAZ, modificamos los extremos protuberantes de los siRNA con varias modificaciones. Específicamente, 2 unidades de un beta-L-nucleósido como la L-timidina (imagen especular de la timidina), de 2'-desoxiribitol, de GNA (glycerol nucleic acids)- timina y del derivado acíclico L-treoninol se introdujeron a los extremos protuberantes y se midió la potencia de silenciamiento (IC50). Tales modificaciones pueden proporcionar pistas fundamentales sobre el requisito estructural necesario para el reconocimiento y carga de la cadena del dominio PAZ de Ago2.
Nord, Dianna M. "Knockdown of the Yes-associated Protein 1 pathway provides a basis for targeted therapy to treat infantile hemangioma." Thesis, Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/53736.
Full textRoy, Matthew Stephen. "Development and application of a high-throughput RNAi screen to reveal novel components of the DNA sensing pathway." Thesis, Harvard University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3567049.
Full textThe mammalian immune system has evolved a complex and diverse set of mechanisms to detect and respond to pathogens by recognizing conserved molecular structures and inducing protective immune responses. While many of these mechanisms are capable of sensing diverse molecular structures, a large fraction of pathogen sensors recognize nucleic acids. Pathogen-derived nucleic acids trigger nucleic acid sensors that typically induce anti-viral or anti-microbial immunity, however host-derived nucleic acids may also activate these sensors and lead to increased risk of inflammatory or autoimmune disease. Animal models and humans lacking key DNA nucleases, such as Trex1/Dnase3, accumulate intracellular DNA and develop progressive autoimmunity marked by increased Type-I Interferon (IFN) expression and inflammatory signatures.
Double-stranded DNA (dsDNA) is a potent inducer of the Type-I IFN response. Many of the sensors and signaling components that drive the IFN signature following simulation with transfected dsDNA (also called 'Interferon Stimulatory DNA' or 'ISD') remain unknown. We set out to identify novel components of the ISD pathway by developing a large-scale loss-of-function genetic perturbation screen of 1003 candidate genes. We interrogated multiple human and murine primary and immortalized cells, tested several Type-I IFN reporters, and considered multiple loss-of-function strategies before proceeding with an RNAi screen whereby mouse embryonic fibroblasts were stimulated with ISD and Type-IFN pathway activation was assessed by measuring Cxcl10 protein by ELISA.
Candidate genes for testing in the RNAi screen were curated from quantitative proteomic screens, IFN-beta and ISD stimulated mRNA expression profiles, and a selection of domain-based proteins including helicases, cytoplasmically located DNA-binding proteins and a set of potential negative regulators including phosphatases, deubiquitinases and known signaling proteins.
We identified a number of novel ISD pathway components including Abcf1, Ptpn1 and Hells. We validated hits through siRNA-resistant cDNA rescue, chemical inhibition or targeted knockout. Additionally, we evaluated protein-protein interactions of our strongest validated hits to develop a network model of the ISD pathway. In addition to the identification of novel ISD pathway components, our enriched screening data set may provide a useful resource of candidate genes involved in the response to cytosolic DNA.
Kingham, Guy L. "Screening for inhibitors of and novel proteins within the homologous recombination DNA repair pathway." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e2988d0b-c6d4-42a8-aef9-f320a13d6391.
Full textLaxman, Navya. "miRNA and Asymmetric siRNA : Small RNAs with Large Effects on Bone Metabolism." Doctoral thesis, Uppsala universitet, Endokrinologi och mineralmetabolism, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-264451.
Full textZwirek, Monika. "Improving barley for biofuel production : investigating the role of 4CL and CCR in the lignin biosynthesis pathway." Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/6785dbbb-f8a4-46f1-b7c4-0c3d0d4dcdd4.
Full textKaimoyo, Evans. "Study of the (+)-Pisatin Biosynthetic Pathway by RNAi and Development of a Novel Method to Elicit the Production of Plant Secondary Metabolites." Tucson, Arizona : University of Arizona, 2006. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1434%5F1%5Fm.pdf&type=application/pdf.
Full textKaimoyo, Evans. "Study of the (+)-Pisatin Biosynthetic Pathway by RNAi and Development of a Novel Method to Elicit the Production of Plant Secondary Metabolites." Diss., The University of Arizona, 2005. http://hdl.handle.net/10150/193608.
Full textBooks on the topic "RNAi pathway"
Muise, Brandon. Examining caspase mediated apoptotic pathways through RNAi as a means of procaspase downregulation. Sudbury, Ont: Laurentian University, 2006.
Find full textservice), ScienceDirect (Online, ed. RNA turnover in eukaryotes: Nucleases, pathways and analysis of mRNA decay. San Diego, Calif: Academic, 2008.
Find full textKekkonen, Viktoria. Characterization of bacterial RNA and DNA signalling pathways that induce cellular dysfunction. Sudbury, Ont: Laurentian University, 2006.
Find full textViral Interactions with Host RNA Decay Pathways. MDPI, 2017. http://dx.doi.org/10.3390/books978-3-03842-503-8.
Full textRna Turnover In Eukaryotes Analysis Of Specialized And Quality Control Rna Decay Pathways. Academic Press, 2008.
Find full textRNA Turnover in Eukaryotes: Analysis of Specialized and Quality Control RNA Decay Pathways. Elsevier, 2008. http://dx.doi.org/10.1016/s0076-6879(08)x0013-8.
Full textRNA Turnover in Eukaryotes: Nucleases, Pathways and Analysis of mRNA Decay. Elsevier, 2008. http://dx.doi.org/10.1016/s0076-6879(08)x0014-x.
Full textD, Smolke Christina, ed. The metabolic pathway engineering handbook: Tools and applications. Boca Raton: CRC Press/Taylor & Francis, 2009.
Find full textSignal Transduction: Pathways, Mechanisms and Diseases. Springer, 2009.
Find full textGluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Vitamin B9 (folate) in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0012.
Full textBook chapters on the topic "RNAi pathway"
Boisvert, Marie-Eve L., and Martin J. Simard. "RNAi Pathway in C. elegans: The Argonautes and Collaborators." In RNA Interference, 21–36. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-75157-1_2.
Full textFisher, Katherine H., Stephen Brown, and Martin P. Zeidler. "Designing RNAi Screens to Identify JAK/STAT Pathway Components." In Methods in Molecular Biology, 81–97. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-242-1_6.
Full textMarois, Eric, and Suzanne Eaton. "RNAi in the Hedgehog Signaling Pathway: pFRiPE, a Vector for Temporally and Spatially Controlled RNAi in Drosophila." In Methods in Molecular Biology, 115–28. Totowa, NJ: Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-516-9_10.
Full textChen, Xiaochu, and Lan Xu. "Genome-Wide RNAi Screening to Dissect the TGF-β Signal Transduction Pathway." In Methods in Molecular Biology, 365–77. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-2966-5_24.
Full textTrombly, Melanie I., and Xiaozhong Wang. "A Recessive Genetic Screen for Components of the RNA Interference Pathway in Mouse Embryonic Stem Cells." In RNAi and microRNA-Mediated Gene Regulation in Stem Cells, 45–63. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-769-3_4.
Full textTanaka, Yoshikazu, Noriko Nakamura, and Junichi Togami. "Altering Flower Color in Transgenic Plants by RNAi-Mediated Engineering of Flavonoid Biosynthetic Pathway." In Methods in Molecular Biology™, 245–57. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-191-8_17.
Full textYang, Jianguo, Jing Shi, Raghavan Venkat, and Kripa Ram. "Functional Analysis of ER Stress Pathway Genes for Apoptosis of NS/0 Cell Line Using RNAi Methods." In Cells and Culture, 447–51. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-3419-9_78.
Full textNejepinska, Jana, Matyas Flemr, and Petr Svoboda. "The Canonical RNA Interference Pathway in Animals." In Regulatory RNAs, 111–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-662-45801-3_5.
Full textArpaia, Salvatore, Olivier Christiaens, Paul Henning Krogh, and Kimberly M. Parker. "Environmental safety assessment of plants expressing RNAi for pest control." In RNAi for plant improvement and protection, 117–30. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789248890.0117.
Full textArpaia, Salvatore, Olivier Christiaens, Paul Henning Krogh, and Kimberly M. Parker. "Environmental safety assessment of plants expressing RNAi for pest control." In RNAi for plant improvement and protection, 117–30. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789248890.0012.
Full textConference papers on the topic "RNAi pathway"
Sánchez-Rivera, Francisco J., David M. Feldser, John Doench, Arjun Bhutkar, Corbin E. Meacham, David E. Root, Michael T. Hemann, and Tyler Jacks. "Abstract 2957: Uncovering tumor-specific components of the p53 pathway using mouse models and RNAi." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2957.
Full textPapageorgiou, Angela, and Joseph Avruch. "Abstract 292: Identification of new components of the mTOR signaling pathway in pancreatic cancer cells by a genome-wide RNAi screen." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-292.
Full textJeon, Jun W., Anthony D. Saleh, Shaleeka Cornelius, Sophie Carlson, Scott Martin, Pinar Ormanoglu, Hui Cheng, et al. "Abstract 605: Linkage of NF-κB pathway and mitosis-related molecules using integrated RNAi screening and transcriptomic analysis of head and neck squamous cell carcinoma." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-605.
Full textFox, EM, TW Miller, F. Ye, Y. Shyr, and CL Arteaga. "Abstract S3-8: RNAi Screening Identifies the Insulin/Insulin-Like Growth Factor-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Estrogen Receptor-Positive Breast Cancer." In Abstracts: Thirty-Third Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 8‐12, 2010; San Antonio, TX. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/0008-5472.sabcs10-s3-8.
Full textAyaz, E. Serdar, and Tolga Can. "Constructing signaling pathways from RNAI data using genetic algorithms." In 2011 6th International Symposium on Health Informatics and Bioinformatics (HIBIT). IEEE, 2011. http://dx.doi.org/10.1109/hibit.2011.6450816.
Full textLi, Huarong. "Systemic RNAi in western corn rootworm does not involve transitive pathways." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.112159.
Full textTanikawa, Chizu, Koji Ueda, Yusuke Nakamura, and Koichi Matsuda. "Abstract 2051: Regulation of RNA processing by PADI4 pathway." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2051.
Full textLi, Yuan, and Shaojie Zhang. "Predicting folding pathways between RNA conformational structures guided by RNA stacks." In the 2nd ACM Conference. New York, New York, USA: ACM Press, 2011. http://dx.doi.org/10.1145/2147805.2147832.
Full textGuo, Sujuan, Kevin Pridham, and Zhi Sheng. "Abstract A04: LINC00467 regulates the autophagy signaling pathway STK11/AMPK." In Abstracts: AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines; December 4-7, 2015; Boston, MA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.nonrna15-a04.
Full textEl-fadl, Rihab, Nasser Rizk, Amena Fadel, and Abdelrahman El Gamal. "The Profile of Hepatic Gene Expression of Glucose Metabolism in Mice on High Fat Diet." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0213.
Full textReports on the topic "RNAi pathway"
Guney, Isil. Dissecting Androgen-Dependent and Independent Signaling Pathways Using RNA Interference-Based Functional Genomics in Human Cells. Fort Belvoir, VA: Defense Technical Information Center, June 2008. http://dx.doi.org/10.21236/ada495676.
Full textGuney, Isil. Dissecting Androgen-Dependent and Independent Signaling Pathways Using RNA Interference-Based Functional Genomics in Human Cells. Fort Belvoir, VA: Defense Technical Information Center, June 2009. http://dx.doi.org/10.21236/ada505263.
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