Journal articles on the topic 'RNA-Targeted small molecules'
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Costales, Matthew G., Haruo Aikawa, Yue Li, Jessica L. Childs-Disney, Daniel Abegg, Dominic G. Hoch, Sai Pradeep Velagapudi, et al. "Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer." Proceedings of the National Academy of Sciences 117, no. 5 (January 21, 2020): 2406–11. http://dx.doi.org/10.1073/pnas.1914286117.
Full textNagano, Konami, Takashi Kamimura, and Gota Kawai. "Interaction between a fluoroquinolone derivative and RNAs with a single bulge." Journal of Biochemistry 171, no. 2 (November 16, 2021): 239–44. http://dx.doi.org/10.1093/jb/mvab124.
Full textSun, Saisai, Jianyi Yang, and Zhaolei Zhang. "RNALigands: a database and web server for RNA–ligand interactions." RNA 28, no. 2 (November 3, 2021): 115–22. http://dx.doi.org/10.1261/rna.078889.121.
Full textTadesse, Kisanet, and Raphael I. Benhamou. "Targeting MicroRNAs with Small Molecules." Non-Coding RNA 10, no. 2 (March 14, 2024): 17. http://dx.doi.org/10.3390/ncrna10020017.
Full textWu, Liping, Jing Pan, Vala Thoroddsen, Deborah R. Wysong, Ronald K. Blackman, Christine E. Bulawa, Alexandra E. Gould, et al. "Novel Small-Molecule Inhibitors of RNA Polymerase III." Eukaryotic Cell 2, no. 2 (April 2003): 256–64. http://dx.doi.org/10.1128/ec.2.2.256-264.2003.
Full textAngelbello, Alicia J., Suzanne G. Rzuczek, Kendra K. Mckee, Jonathan L. Chen, Hailey Olafson, Michael D. Cameron, Walter N. Moss, Eric T. Wang, and Matthew D. Disney. "Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model." Proceedings of the National Academy of Sciences 116, no. 16 (March 29, 2019): 7799–804. http://dx.doi.org/10.1073/pnas.1901484116.
Full textAlagia, Adele, Jana Tereňová, Ruth F. Ketley, Arianna Di Fazio, Irina Chelysheva, and Monika Gullerova. "Small vault RNA1-2 modulates expression of cell membrane proteins through nascent RNA silencing." Life Science Alliance 6, no. 6 (April 10, 2023): e202302054. http://dx.doi.org/10.26508/lsa.202302054.
Full textFrancois-Moutal, Liberty, David Donald Scott, and May Khanna. "Direct targeting of TDP-43, from small molecules to biologics: the therapeutic landscape." RSC Chemical Biology 2, no. 4 (2021): 1158–66. http://dx.doi.org/10.1039/d1cb00110h.
Full textSmola, Matthew J., Krista Marran, Sarah E. Thompson, Brittani Patterson, Roheeth K. Pavana, Caleb Sutherland, Jessica A. Sorrentino, and Katherine D. Warner. "Abstract 680: Leveraging an RNA-targeting platform for the discovery of cell-active c-MYC mRNA-binding small molecules." Cancer Research 84, no. 6_Supplement (March 22, 2024): 680. http://dx.doi.org/10.1158/1538-7445.am2024-680.
Full textMirón-Barroso, Sofía, Joana S. Correia, Adam E. Frampton, Mark P. Lythgoe, James Clark, Laura Tookman, Silvia Ottaviani, et al. "Polymeric Carriers for Delivery of RNA Cancer Therapeutics." Non-Coding RNA 8, no. 4 (August 2, 2022): 58. http://dx.doi.org/10.3390/ncrna8040058.
Full textMartín-Villamil, María, Isaías Sanmartín, Ángela Moreno, and José Gallego. "Pharmacophore-Based Discovery of Viral RNA Conformational Modulators." Pharmaceuticals 15, no. 6 (June 14, 2022): 748. http://dx.doi.org/10.3390/ph15060748.
Full textHardigan, Andrew A., Brian S. Roberts, Dianna E. Moore, Ryne C. Ramaker, Angela L. Jones, and Richard M. Myers. "CRISPR/Cas9-targeted removal of unwanted sequences from small-RNA sequencing libraries." Nucleic Acids Research 47, no. 14 (June 5, 2019): e84-e84. http://dx.doi.org/10.1093/nar/gkz425.
Full textTran, Anh Thi-Phuong, Duc Huy Vo, Audrey Di Giorgio, and Maria Duca. "ID: 1083 Targeting the production of oncogenic miRNAs using synthetic small molecules." Biomedical Research and Therapy 4, S (September 5, 2017): 170. http://dx.doi.org/10.15419/bmrat.v4is.357.
Full textPalazzotti, Deborah, Martina Sguilla, Giuseppe Manfroni, Violetta Cecchetti, Andrea Astolfi, and Maria Letizia Barreca. "Small Molecule Drugs Targeting Viral Polymerases." Pharmaceuticals 17, no. 5 (May 20, 2024): 661. http://dx.doi.org/10.3390/ph17050661.
Full textLiu, Yuan, Mads B. Larsen, Bo Lin, Jason R. Kennerdell, Irene Alfaras, Daniel P. Camarco, Ferhan Tuncer, Toren Finkel, and Bill B. Chen. "Abstract 1805: Identification of a small molecule that induces targeted protein degradation of ADAR1." Cancer Research 83, no. 7_Supplement (April 4, 2023): 1805. http://dx.doi.org/10.1158/1538-7445.am2023-1805.
Full textAkbar, Sehrish, Yao Wei, and Mu-Qing Zhang. "RNA Interference: Promising Approach to Combat Plant Viruses." International Journal of Molecular Sciences 23, no. 10 (May 10, 2022): 5312. http://dx.doi.org/10.3390/ijms23105312.
Full textCotten, M., G. Schaffner, and M. L. Birnstiel. "Ribozyme, antisense RNA, and antisense DNA inhibition of U7 small nuclear ribonucleoprotein-mediated histone pre-mRNA processing in vitro." Molecular and Cellular Biology 9, no. 10 (October 1989): 4479–87. http://dx.doi.org/10.1128/mcb.9.10.4479-4487.1989.
Full textCotten, M., G. Schaffner, and M. L. Birnstiel. "Ribozyme, antisense RNA, and antisense DNA inhibition of U7 small nuclear ribonucleoprotein-mediated histone pre-mRNA processing in vitro." Molecular and Cellular Biology 9, no. 10 (October 1989): 4479–87. http://dx.doi.org/10.1128/mcb.9.10.4479.
Full textThaper, Daksh L., Ravi Munuganti, Shaghayegh Nouruzi, Sahil Kumar, Soojin Kim, Sepideh Vahid, Olena Sivak, et al. "First-in-field small molecule inhibitors targeting BRN2 as a therapeutic strategy for small cell prostate cancer." Journal of Clinical Oncology 37, no. 7_suppl (March 1, 2019): 260. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.260.
Full textAla, Ugo. "Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story." Cells 9, no. 7 (June 28, 2020): 1574. http://dx.doi.org/10.3390/cells9071574.
Full textRimoldi, O. J., B. Raghu, M. K. Nag, and G. L. Eliceiri. "Three new small nucleolar RNAs that are psoralen cross-linked in vivo to unique regions of pre-rRNA." Molecular and Cellular Biology 13, no. 7 (July 1993): 4382–90. http://dx.doi.org/10.1128/mcb.13.7.4382-4390.1993.
Full textRimoldi, O. J., B. Raghu, M. K. Nag, and G. L. Eliceiri. "Three new small nucleolar RNAs that are psoralen cross-linked in vivo to unique regions of pre-rRNA." Molecular and Cellular Biology 13, no. 7 (July 1993): 4382–90. http://dx.doi.org/10.1128/mcb.13.7.4382.
Full textFei, Yue, Tünde Nyikó, and Attila Molnar. "Non-perfectly matching small RNAs can induce stable and heritable epigenetic modifications and can be used as molecular markers to trace the origin and fate of silencing RNAs." Nucleic Acids Research 49, no. 4 (February 1, 2021): 1900–1913. http://dx.doi.org/10.1093/nar/gkab023.
Full textTao, Wei, Arif Yurdagul, Na Kong, Wenliang Li, Xiaobo Wang, Amanda C. Doran, Chan Feng, et al. "siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice." Science Translational Medicine 12, no. 553 (July 22, 2020): eaay1063. http://dx.doi.org/10.1126/scitranslmed.aay1063.
Full textRojas-Cruz, Alexis Felipe, and Clara Isabel Bermúdez-Santana. "Computational Prediction of RNA–RNA Interactions between Small RNA Tracks from Betacoronavirus Nonstructural Protein 3 and Neurotrophin Genes during Infection of an Epithelial Lung Cancer Cell Line: Potential Role of Novel Small Regulatory RNA." Viruses 15, no. 8 (July 28, 2023): 1647. http://dx.doi.org/10.3390/v15081647.
Full textAlonso-Valenteen, Felix, Sayuri Pacheco, Dustin Srinivas, Altan Rentsendorj, David Chu, Jay Lubow, Jessica Sims, et al. "HER3-targeted protein chimera forms endosomolytic capsomeres and self-assembles into stealth nucleocapsids for systemic tumor homing of RNA interference in vivo." Nucleic Acids Research 47, no. 21 (October 16, 2019): 11020–43. http://dx.doi.org/10.1093/nar/gkz900.
Full textServan de Almeida, Renata, Djénéba Keita, Geneviève Libeau, and Emmanuel Albina. "Control of ruminant morbillivirus replication by small interfering RNA." Journal of General Virology 88, no. 8 (August 1, 2007): 2307–11. http://dx.doi.org/10.1099/vir.0.82981-0.
Full textGoldberg, Zelanna, Christian Maine, Gabrielle P. Dailey, Christine Domingo, Gaelle Picarda, Hunter Little, Annie Chou, et al. "Abstract 6403: A self-replicating RNA precision medicine approach to overcoming resistance to endocrine therapy in ER+BC." Cancer Research 83, no. 7_Supplement (April 4, 2023): 6403. http://dx.doi.org/10.1158/1538-7445.am2023-6403.
Full textLi, Quan, Yanan Wang, Zhihui Sun, Haiyang Li, and Huan Liu. "The Biosynthesis Process of Small RNA and Its Pivotal Roles in Plant Development." International Journal of Molecular Sciences 25, no. 14 (July 12, 2024): 7680. http://dx.doi.org/10.3390/ijms25147680.
Full textAshander, Liam M., Binoy Appukuttan, Yuefang Ma, Dione Gardner-Stephen, and Justine R. Smith. "Targeting Endothelial Adhesion Molecule Transcription for Treatment of Inflammatory Disease: A Proof-of-Concept Study." Mediators of Inflammation 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/7945848.
Full textHassanzadeh, Leila, Suxiang Chen, and Rakesh Veedu. "Radiolabeling of Nucleic Acid Aptamers for Highly Sensitive Disease-Specific Molecular Imaging." Pharmaceuticals 11, no. 4 (October 15, 2018): 106. http://dx.doi.org/10.3390/ph11040106.
Full textLavender, Helen, Kevin Brady, Frances Burden, Oona Delpuech-Adams, Hubert Denise, Amy Palmer, Hannah Perkins, et al. "In VitroCharacterization of the Activity of PF-05095808, a Novel Biological Agent for Hepatitis C Virus Therapy." Antimicrobial Agents and Chemotherapy 56, no. 3 (December 27, 2011): 1364–75. http://dx.doi.org/10.1128/aac.05357-11.
Full textColl-SanMartin, Laia, Veronica Davalos, David Piñeyro, Margalida Rosselló-Tortella, Alberto Bueno-Costa, Fernando Setien, Alberto Villanueva, et al. "Gene Amplification-Associated Overexpression of the Selenoprotein tRNA Enzyme TRIT1 Confers Sensitivity to Arsenic Trioxide in Small-Cell Lung Cancer." Cancers 13, no. 8 (April 14, 2021): 1869. http://dx.doi.org/10.3390/cancers13081869.
Full textHagiwara, Shinji, Aaron McClelland, and Phillip Kantharidis. "MicroRNA in Diabetic Nephropathy: Renin Angiotensin, AGE/RAGE, and Oxidative Stress Pathway." Journal of Diabetes Research 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/173783.
Full textJoshi, Mansi, Pranay Dey, and Abhijit De. "Recent advancements in targeted protein knockdown technologies—emerging paradigms for targeted therapy." Exploration of Targeted Anti-tumor Therapy 4, no. 6 (December 26, 2023): 1227–48. http://dx.doi.org/10.37349/etat.2023.00194.
Full textTidwell, Elizabeth D., Ingrid R. Kilde, Suada Leskaj, and Markos Koutmos. "Fluorescent Ligand Equilibrium Displacement: A High-Throughput Method for Identification of FMN Riboswitch-Binding Small Molecules." International Journal of Molecular Sciences 25, no. 2 (January 6, 2024): 735. http://dx.doi.org/10.3390/ijms25020735.
Full textKalynych, Sergei, Lenka Pálková, and Pavel Plevka. "The Structure of Human Parechovirus 1 Reveals an Association of the RNA Genome with the Capsid." Journal of Virology 90, no. 3 (November 18, 2015): 1377–86. http://dx.doi.org/10.1128/jvi.02346-15.
Full textShen, Linyuan, Zhendong Tan, Mailin Gan, Qiang Li, Lei Chen, Lili Niu, Dongmei Jiang, et al. "tRNA-Derived Small Non-Coding RNAs as Novel Epigenetic Molecules Regulating Adipogenesis." Biomolecules 9, no. 7 (July 11, 2019): 274. http://dx.doi.org/10.3390/biom9070274.
Full textSimba-Lahuasi, Alvaro, Ángel Cantero-Camacho, Romel Rosales, Briana Lynn McGovern, M. Luis Rodríguez, Vicente Marchán, Kris M. White, Adolfo García-Sastre, and José Gallego. "SARS-CoV-2 Inhibitors Identified by Phenotypic Analysis of a Collection of Viral RNA-Binding Molecules." Pharmaceuticals 15, no. 12 (November 22, 2022): 1448. http://dx.doi.org/10.3390/ph15121448.
Full textHarrington, Lucas B., David Burstein, Janice S. Chen, David Paez-Espino, Enbo Ma, Isaac P. Witte, Joshua C. Cofsky, Nikos C. Kyrpides, Jillian F. Banfield, and Jennifer A. Doudna. "Programmed DNA destruction by miniature CRISPR-Cas14 enzymes." Science 362, no. 6416 (October 18, 2018): 839–42. http://dx.doi.org/10.1126/science.aav4294.
Full textMourenza, Álvaro, Blanca Lorente-Torres, Elena Durante, Jesús Llano-Verdeja, Jesús F. Aparicio, Arsenio Fernández-López, José A. Gil, Luis M. Mateos, and Michal Letek. "Understanding microRNAs in the Context of Infection to Find New Treatments against Human Bacterial Pathogens." Antibiotics 11, no. 3 (March 8, 2022): 356. http://dx.doi.org/10.3390/antibiotics11030356.
Full textCrisci, Amitrano, Saggese, Muto, Sarno, Mele, Vitale, Ronga, Berretta, and Di Francia. "Overview of Current Targeted Anti-Cancer Drugs for Therapy in Onco-Hematology." Medicina 55, no. 8 (July 28, 2019): 414. http://dx.doi.org/10.3390/medicina55080414.
Full textCiccone, Giuseppe, Maria Luigia Ibba, Gabriele Coppola, Silvia Catuogno, and Carla Lucia Esposito. "The Small RNA Landscape in NSCLC: Current Therapeutic Applications and Progresses." International Journal of Molecular Sciences 24, no. 7 (March 24, 2023): 6121. http://dx.doi.org/10.3390/ijms24076121.
Full textMorais, Pedro, Rui Zhang, and Yi-Tao Yu. "Therapeutic Nonsense Suppression Modalities: From Small Molecules to Nucleic Acid-Based Approaches." Biomedicines 12, no. 6 (June 10, 2024): 1284. http://dx.doi.org/10.3390/biomedicines12061284.
Full textXiao, Fei, Chenglong Wang, Jianping Peng, Xing Zhou, Ding Ma, Yu Wang, Yanpeng Li, Xiaodong Chen, and Chuandong Wang. "Changes in Small Noncoding RNA Expression during Chondrocyte Senescence." CARTILAGE 13, no. 3 (July 2022): 194760352211181. http://dx.doi.org/10.1177/19476035221118165.
Full textKakumani, Pavan Kumar, Louis-Mathieu Harvey, François Houle, Tanit Guitart, Fátima Gebauer, and Martin J. Simard. "CSDE1 controls gene expression through the miRNA-mediated decay machinery." Life Science Alliance 3, no. 4 (March 11, 2020): e201900632. http://dx.doi.org/10.26508/lsa.201900632.
Full textCunningham, Tyler A., Derek Essegian, Stephan Schürer, and Jonathan H. Schatz. "Identification of Tractable Drug-like eIF4Al Inhibitors with Potent Anti-Tumor Activity." Blood 134, Supplement_1 (November 13, 2019): 5760. http://dx.doi.org/10.1182/blood-2019-130494.
Full textAughton, Karen, Helen Kalirai, and Sarah E. Coupland. "MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators." International Journal of Molecular Sciences 21, no. 16 (August 6, 2020): 5648. http://dx.doi.org/10.3390/ijms21165648.
Full textChauhan, Waseem, Sudharshan SJ, Sweta Kafle, and Rahima Zennadi. "SnoRNAs: Exploring Their Implication in Human Diseases." International Journal of Molecular Sciences 25, no. 13 (June 29, 2024): 7202. http://dx.doi.org/10.3390/ijms25137202.
Full textUyeno, Yutaka, Yuji Sekiguchi, Akiko Sunaga, Hiroki Yoshida, and Yoichi Kamagata. "Sequence-Specific Cleavage of Small-Subunit (SSU) rRNA with Oligonucleotides and RNase H: a Rapid and Simple Approach to SSU rRNA-Based Quantitative Detection of Microorganisms." Applied and Environmental Microbiology 70, no. 6 (June 2004): 3650–63. http://dx.doi.org/10.1128/aem.70.6.3650-3663.2004.
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