Academic literature on the topic 'RNA-Targeted small molecules'
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Journal articles on the topic "RNA-Targeted small molecules"
Costales, Matthew G., Haruo Aikawa, Yue Li, Jessica L. Childs-Disney, Daniel Abegg, Dominic G. Hoch, Sai Pradeep Velagapudi, et al. "Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer." Proceedings of the National Academy of Sciences 117, no. 5 (January 21, 2020): 2406–11. http://dx.doi.org/10.1073/pnas.1914286117.
Full textNagano, Konami, Takashi Kamimura, and Gota Kawai. "Interaction between a fluoroquinolone derivative and RNAs with a single bulge." Journal of Biochemistry 171, no. 2 (November 16, 2021): 239–44. http://dx.doi.org/10.1093/jb/mvab124.
Full textSun, Saisai, Jianyi Yang, and Zhaolei Zhang. "RNALigands: a database and web server for RNA–ligand interactions." RNA 28, no. 2 (November 3, 2021): 115–22. http://dx.doi.org/10.1261/rna.078889.121.
Full textTadesse, Kisanet, and Raphael I. Benhamou. "Targeting MicroRNAs with Small Molecules." Non-Coding RNA 10, no. 2 (March 14, 2024): 17. http://dx.doi.org/10.3390/ncrna10020017.
Full textWu, Liping, Jing Pan, Vala Thoroddsen, Deborah R. Wysong, Ronald K. Blackman, Christine E. Bulawa, Alexandra E. Gould, et al. "Novel Small-Molecule Inhibitors of RNA Polymerase III." Eukaryotic Cell 2, no. 2 (April 2003): 256–64. http://dx.doi.org/10.1128/ec.2.2.256-264.2003.
Full textAngelbello, Alicia J., Suzanne G. Rzuczek, Kendra K. Mckee, Jonathan L. Chen, Hailey Olafson, Michael D. Cameron, Walter N. Moss, Eric T. Wang, and Matthew D. Disney. "Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model." Proceedings of the National Academy of Sciences 116, no. 16 (March 29, 2019): 7799–804. http://dx.doi.org/10.1073/pnas.1901484116.
Full textAlagia, Adele, Jana Tereňová, Ruth F. Ketley, Arianna Di Fazio, Irina Chelysheva, and Monika Gullerova. "Small vault RNA1-2 modulates expression of cell membrane proteins through nascent RNA silencing." Life Science Alliance 6, no. 6 (April 10, 2023): e202302054. http://dx.doi.org/10.26508/lsa.202302054.
Full textFrancois-Moutal, Liberty, David Donald Scott, and May Khanna. "Direct targeting of TDP-43, from small molecules to biologics: the therapeutic landscape." RSC Chemical Biology 2, no. 4 (2021): 1158–66. http://dx.doi.org/10.1039/d1cb00110h.
Full textSmola, Matthew J., Krista Marran, Sarah E. Thompson, Brittani Patterson, Roheeth K. Pavana, Caleb Sutherland, Jessica A. Sorrentino, and Katherine D. Warner. "Abstract 680: Leveraging an RNA-targeting platform for the discovery of cell-active c-MYC mRNA-binding small molecules." Cancer Research 84, no. 6_Supplement (March 22, 2024): 680. http://dx.doi.org/10.1158/1538-7445.am2024-680.
Full textMirón-Barroso, Sofía, Joana S. Correia, Adam E. Frampton, Mark P. Lythgoe, James Clark, Laura Tookman, Silvia Ottaviani, et al. "Polymeric Carriers for Delivery of RNA Cancer Therapeutics." Non-Coding RNA 8, no. 4 (August 2, 2022): 58. http://dx.doi.org/10.3390/ncrna8040058.
Full textDissertations / Theses on the topic "RNA-Targeted small molecules"
Panei, Francesco Paolo. "Advanced computational techniques to aid the rational design of small molecules targeting RNA." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS106.
Full textRNA molecules have recently gained huge relevance as therapeutic targets. The direct targeting of RNA with small molecule drugs emerges for its wide applicability to different classes of RNAs. Despite this potential, the field is still in its infancy and the number of available RNA-targeted drugs remains limited. A major challenge is constituted by the highly flexible and elusive nature of the RNA targets. Nonetheless, RNA flexibility also presents unique opportunities that could be leveraged to enhance the efficacy and selectivity of newly designed therapeutic agents. To this end, computer-aided drug design techniques emerge as a natural and comprehensive approach. However, existing tools do not fully account for the flexibility of the RNA. The project of this PhD work aims to build a computational framework toward the rational design of compounds targeting RNA. The first essential step for any structure-based approach is the analysis of the available structural knowledge. However, a comprehensive, curated, and regularly updated repository for the scientific community was lacking. To fill this gap, I curated the creation of HARIBOSS ("Harnessing RIBOnucleic acid - Small molecule Structures"), a database of all the experimentally-determined structures of RNA-small molecule complexes retrieved from the PDB database. HARIBOSS is available via a dedicated web interface (https://hariboss.pasteur.cloud), and is regularly updated with all the structures resolved by X-ray, NMR, and cryo-EM, in which ligands with drug-like properties interact with RNA molecules. Each HARIBOSS entry is annotated with physico-chemical properties of ligands and RNA pockets. HARIBOSS repository, constantly updated, will facilitate the exploration of drug-like compounds known to bind RNA, the analysis of ligands and pockets properties and, ultimately, the development of in silico strategies to identify RNA-targeting small molecules. In coincidence of its release, it was possible to highlight that the majority of RNA binding pockets are unsuitable for interactions with drug-like molecules, attributed to the lower hydrophobicity and increased solvent exposure compared to protein binding sites. However, this emerges from a static depiction of RNA, which may not fully capture their interaction mechanisms with small molecules. In a broader perspective, it was necessary to introduce more advanced computational techniques for an effective accounting of RNA flexibility in the characterization of potential binding sites. In this direction, I implemented SHAMAN, a computational technique to identify potential small-molecule binding sites in RNA structural ensembles. SHAMAN enables the exploration of the target RNA conformational landscape through atomistic molecular dynamics. Simultaneously, it efficiently identifies RNA pockets using small probe compounds whose exploration of the RNA surface is accelerated by enhanced-sampling techniques. In a benchmark encompassing diverse large, structured riboswitches as well as small, flexible viral RNAs, SHAMAN accurately located experimentally resolved pockets, ranking them as preferred probe hotspots. Notably, SHAMAN accuracy was superior to other tools working on static RNA structures in the realistic drug discovery scenario where only apo structures of the target are available. This establishes SHAMAN as a robust platform for future drug design endeavors targeting RNA with small molecules, especially considering its potential applicability in virtual screening campaigns. Overall, my research contributed to enhance our understanding and utilization of RNA as a target for small molecule drugs, paving the way for more effective drug design strategies in this evolving field
Chung, Janet. "Investigation of small molecule - SL1 RNA interactions and implications in drug design targeted at HIV-1 genomic dimer maturation." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390040.
Full textBooks on the topic "RNA-Targeted small molecules"
Slabý, Ondřej. MicroRNAs in solid cancer: From biomarkers to therapeutic targets. Hauppauge, N.Y: Nova Science, 2011.
Find full textBook chapters on the topic "RNA-Targeted small molecules"
Fladung, Matthias, Hely Häggman, and Suvi Sutela. "Application of RNAi technology in forest trees." In RNAi for plant improvement and protection, 54–71. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789248890.0007.
Full textFladung, Matthias, Hely Häggman, and Suvi Sutela. "Application of RNAi technology in forest trees." In RNAi for plant improvement and protection, 54–71. Wallingford: CABI, 2021. http://dx.doi.org/10.1079/9781789248890.0054.
Full textUrsu, Andrei, Matthew G. Costales, Jessica L. Childs-Disney, and Matthew D. Disney. "Chapter 15. Small-molecule Targeted Degradation of RNA." In Protein Degradation with New Chemical Modalities, 317–36. Cambridge: Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781839160691-00317.
Full textDamski, Caio, and Kevin V. Morris. "Targeted Small Noncoding RNA-Directed Gene Activation in Human Cells." In Methods in Molecular Biology, 1–10. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0931-5_1.
Full textWilson, W. David, and Ananya Paul. "Reversible Small Molecule–Nucleic Acid Interactions." In Nucleic Acids in Chemistry and Biology, 477–521. The Royal Society of Chemistry, 2022. http://dx.doi.org/10.1039/9781837671328-00477.
Full textOktay, Yavuz. "Metabolomiks ve Uygulamaları." In Moleküler Biyoloji ve Genetik, 311–28. Türkiye Bilimler Akademisi, 2023. http://dx.doi.org/10.53478/tuba.978-625-8352-48-1.ch12.
Full textHampson, Ian, Gavin Batman, and Thomas Walker. "RNA interference technology." In Tools and Techniques in Biomolecular Science. Oxford University Press, 2013. http://dx.doi.org/10.1093/hesc/9780199695560.003.0006.
Full textIqbal, Nashra, Priyanka Vishwakarma, and Vidya Meenakshi. "NEXT GENERATION SEQUENCING FOR CANCER DIAGNOSIS." In Futuristic Trends in Biotechnology Volume 3 Book 21, 137–51. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bkbt21p1ch11.
Full textScarpino, Stefania, and Umberto Malapelle. "Liquid Biopsy: A New Diagnostic Strategy and Not Only for Lung Cancer?" In Histopathology and Liquid Biopsy [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.94838.
Full textConference papers on the topic "RNA-Targeted small molecules"
Kahen, Elliot J., Darcy Welch, Jamie Teer, Andrew S. Brohl, Sean J. Yoder, Yonghong Zhang, Ling Cen, and Damon Reed. "Abstract 3010: Osteosarcoma cell lines display both shared and unique vulnerabilities to 140 targeted small molecules with RNA-seq revealing putative mechanisms." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3010.
Full textKahen, Elliot J., Darcy Welch, Jamie Teer, Andrew S. Brohl, Sean J. Yoder, Yonghong Zhang, Ling Cen, and Damon Reed. "Abstract 3010: Osteosarcoma cell lines display both shared and unique vulnerabilities to 140 targeted small molecules with RNA-seq revealing putative mechanisms." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3010.
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