Journal articles: 'Rlnn1'

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Williams, K., S. Taylor, P. Bogacki, M. Pallotta, H. Bariana, and H. Wallwork. "Mapping of the root lesion nematode (Pratylenchus neglectus) resistance gene Rlnn1 in wheat." Theoretical and Applied Genetics 104, no. 5 (April 2002): 874–79. http://dx.doi.org/10.1007/s00122-001-0839-3.

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Marshall, Sarah A., Jonathan T. McGuane, Yu May Soh, Helen M. Gehring, Emma Simpson, and Laura J. Parry. "Abnormal extracellular matrix remodelling in the cervix of pregnant relaxin-deficient mice is not associated with reduced matrix metalloproteinase expression or activity." Reproduction, Fertility and Development 30, no. 9 (2018): 1214. http://dx.doi.org/10.1071/rd17544.

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Relaxin regulates cervical extracellular matrix (ECM) remodelling during pregnancy by modifying collagen and other ECM molecules by unknown mechanisms. We hypothesised that abnormal collagen remodelling in the cervix of pregnant relaxin-deficient (Rln1−/−) mice is due to excessive collagen (Col1a1 and Col3a1) and decreased matrix metalloproteinases (Mmp2, Mmp9, Mmp13 and Mmp7) and oestrogen receptors (Esr1 and Esr2). Quantitative polymerase chain reaction, gelatinase zymography, MMP activity assays and histological staining evaluated changes in ECM in pregnant wildtype (Rln1+/+) and Rln1−/− mice. Cervical Col1a1, Col3a1 and total collagen increased in Rln1−/− mice and were higher at term compared with Rln1+/+ mice. This was not correlated with a decrease in gelatinase (Mmp2, Mmp9) expression or activity, Mmp7 or Mmp13 expression, which were all significantly higher in Rln1−/− mice. In late pregnancy, circulating MMP2 and MMP9 were unchanged. Esr1 expression was highest in Rln1+/+ and Rln1−/− mice in late pregnancy, coinciding with a decrease in Esr2 in Rln1+/+ but not Rln1−/− mice. The relaxin receptor (Rxfp1) decreased slightly in late-pregnant Rln1+/+ mice, but was significantly higher in Rln1−/− mice. In summary, relaxin deficiency results in increased cervical collagen in late pregnancy, which is not explained by a reduction in Mmp expression or activity or decreased Rxfp1. However, an imbalance between Esr1 and Esr2 may be involved.

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Brandsen, Sarah, Kevin D. Stubbs, and Henry D. Pfister. "Reinforcement Learning with Neural Networks for Quantum Multiple Hypothesis Testing." Quantum 6 (January 26, 2022): 633. http://dx.doi.org/10.22331/q-2022-01-26-633.

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Reinforcement learning with neural networks (RLNN) has recently demonstrated great promise for many problems, including some problems in quantum information theory. In this work, we apply RLNN to quantum hypothesis testing and determine the optimal measurement strategy for distinguishing between multiple quantum states {ρj} while minimizing the error probability. In the case where the candidate states correspond to a quantum system with many qubit subsystems, implementing the optimal measurement on the entire system is experimentally infeasible. We use RLNN to find locally-adaptive measurement strategies that are experimentally feasible, where only one quantum subsystem is measured in each round. We provide numerical results which demonstrate that RLNN successfully finds the optimal local approach, even for candidate states up to 20 subsystems. We additionally demonstrate that the RLNN strategy meets or exceeds the success probability for a modified locally greedy approach in each random trial.While the use of RLNN is highly successful for designing adaptive local measurement strategies, in general a significant gap can exist between the success probability of the optimal locally-adaptive measurement strategy and the optimal collective measurement. We build on previous work to provide a set of necessary and sufficient conditions for collective protocols to strictly outperform locally adaptive protocols. We also provide a new example which, to our knowledge, is the simplest known state set exhibiting a significant gap between local and collective protocols. This result raises interesting new questions about the gap between theoretically optimal measurement strategies and practically implementable measurement strategies.

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Feng, Shu, Natalia V. Bogatcheva, Aparna A. Kamat, Anne Truong, and Alexander I. Agoulnik. "Endocrine Effects of Relaxin Overexpression in Mice." Endocrinology 147, no. 1 (January 1, 2006): 407–14. http://dx.doi.org/10.1210/en.2005-0626.

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Relaxin is a small peptide hormone with a variety of biological functions. To investigate the systemic endocrine effects of relaxin, we produced mice with transgenic overexpression of the Rln1 gene, Tg(Rln1), driven by rat insulin 2 promoter. The expression of relaxin was detected in the pancreas of the transgenic animals. An analysis of the sera from the transgenic animals revealed at least 20-fold elevation of the level of bioactive relaxin. Transgenic animals had normal viability and fertility in both sexes. Transgenic overexpression of Rln1 did not rescue the undescended testis phenotype in Insl3-deficient males, suggesting that in vivo relaxin does not interact with the insulin-like 3 factor receptor, leucine-rich repeats-containing G protein-coupled receptor 8, Lgr8. Phenotypically, the excess of relaxin resulted in hypertrophic nipple development in virgin female mice. Deletion of the relaxin receptor, leucine-rich repeats-containing G protein-coupled receptor 7, Lgr7, in Tg(Rln1) animals abrogated the development of enlarged nipples in females, indicating that relaxin exerts its effect through Lgr7 alone. The levels of previously defined targets of relaxin signaling, such as matrix metalloproteinases 2 and 9, vascular endothelial growth factor, or nitric oxide, were similar in the sera of the transgenic and wild-type mice. However, the total plasma protein concentration in male Tg(Rln1) mice was lower than that in control animals. The livers of male Tg(Rln1) mice exhibited significantly higher hydroxyproline content, indicative of increased collagen deposition. Our results indicate that relaxin overexpression causes gender-specific changes in liver collagen metabolism.

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Quang Huy, Đặng, Nguyen Minh Ngoc, and Le Ngoc Thanh. "RỐI LOẠN NHỊP NHĨ Ở BỆNH NHÂN THÔNG LIÊN NHĨ: TỈ LỆ MẮC BỆNH, DIỄN BIẾN, TIÊN LƯỢNG VÀ CHỈ ĐỊNH ĐIỀU TRỊ." Tạp chí Phẫu thuật và Tim mạch và Lồng ngực Việt Nam 27 (October 26, 2020): 37–48. http://dx.doi.org/10.47972/vjcts.27.2019.147.

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RLNN trong bệnh TLN bao gồm: rung nhĩ, cuồng nhĩ và nhịp nhanh nhĩ. Tỉ lệ mắc bệnh tăng theo tuổi, sự khác biệt có ý nghĩa thống kê ở độ tuổi 40. Đường kính nhĩ trái, mức độ hở van hai lá và mức độ hở van ba lá là những yếu tố tiên lượng của RLNN. Mặc dù RLNN giảm đi sau khi đóng TLN bằng can thiệp hoặc phẫu thuật, có thể xuất hiện rối loạn nhịp mới với thời gian theo dõi lâu dài.Phẫu thuật Maze với mục đích điều trị hoặc dự phòng rối loạn nhịp giúp làm giảm nguy cơ nhồi máu não và biến chứng chảy máu do thuốc chống đông. Các bằng chứng khoa học cho thấy RLNN nên được chẩn đoán xác định trước mổ. Phẫu thuật Maze nên được kết hợp với đóng TLN đem lại hiệu quả điều trị toàn diện cho bệnh nhân.

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Huy, Đặng Quang, Nguyen Minh Ngoc, and Le Ngoc Thanh. "RỐI LOẠN NHỊP NHĨ Ở BỆNH NHÂN THÔNG LIÊN NHĨ: TỈ LỆ MẮC BỆNH, DIỄN BIẾN, TIÊN LƯỢNG VÀ CHỈ ĐỊNH ĐIỀU TRỊ." Tạp chí Phẫu thuật Tim mạch và Lồng ngực Việt Nam 27 (November 3, 2020): 37–48. http://dx.doi.org/10.47972/vjcts.v27i.147.

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RLNN trong bệnh TLN bao gồm: rung nhĩ, cuồng nhĩ và nhịp nhanh nhĩ. Tỉ lệ mắc bệnh tăng theo tuổi, sự khác biệt có ý nghĩa thống kê ở độ tuổi 40. Đường kính nhĩ trái, mức độ hở van hai lá và mức độ hở van ba lá là những yếu tố tiên lượng của RLNN. Mặc dù RLNN giảm đi sau khi đóng TLN bằng can thiệp hoặc phẫu thuật, có thể xuất hiện rối loạn nhịp mới với thời gian theo dõi lâu dài.Phẫu thuật Maze với mục đích điều trị hoặc dự phòng rối loạn nhịp giúp làm giảm nguy cơ nhồi máu não và biến chứng chảy máu do thuốc chống đông. Các bằng chứng khoa học cho thấy RLNN nên được chẩn đoán xác định trước mổ. Phẫu thuật Maze nên được kết hợp với đóng TLN đem lại hiệu quả điều trị toàn diện cho bệnh nhân.

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Yamasato, Kelly, Pai-Jong Stacy Tsai, James Davis, Sandra Y. Yamamoto, and Gillian D. Bryant-Greenwood. "Human relaxins (RLNH1, RLNH2), their receptor (RXFP1) and fetoplacental growth." Reproduction 154, no. 1 (July 2017): 67–77. http://dx.doi.org/10.1530/rep-17-0039.

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Relaxin, a systemic and placental hormone, has potential roles in fetoplacental growth. Human placenta expresses two RLN genes, RLNH1 and RLNH2. Maternal obesity is common and is associated with abnormal fetal growth. Our aims were to relate systemic and cord blood RLNH2, placental RLNs and their receptor (RXFP1) with fetoplacental growth in context of maternal body mass index, and associations with insulin-like growth factor 2 (IGF2) and vascular endothelial growth factor A (VEGFA) in the same placentas. Systemic, cord blood and placental samples were collected prior to term labor, divided by prepregnancy body mass index: underweight/normal (N = 25) and overweight/obese (N = 44). Blood RLNH2 was measured by ELISA; placental RLNH2, RLNH1, RXFP1, IGF2 and VEGFA were measured by quantitative immunohistochemistry and mRNAs were measured by quantitative reverse transcription PCR. Birthweight increased with systemic RLNH2 only in underweight/normal women (P = 0.036). Syncytiotrophoblast RLNH2 was increased in overweight/obese patients (P = 0.017) and was associated with placental weight in all subjects (P = 0.038). RLNH1 had no associations with birthweight or placental weight, but was associated with increased trophoblast and endothelial IGF2 and VEGFA, due to female fetal sex. Thus, while systemic RLNH2 may be involved in birthweight regulation in underweight/normal women, placental RLNH2 in all subjects may be involved in placental weight. A strong association of trophoblast IGF2 with birthweight and placental weight in overweight/obese women suggests its importance. However, an association of only RLNH1 with placental IGF2 and VEGFA was dependent upon female fetal sex. These results suggest that both systemic and placental RLNs may be associated with fetoplacental growth.

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Kamat, Aparna A., Shu Feng, Natalia V. Bogatcheva, Anne Truong, Colin E. Bishop, and Alexander I. Agoulnik. "Genetic Targeting of Relaxin and Insulin-Like Factor 3 Receptors in Mice." Endocrinology 145, no. 10 (October 1, 2004): 4712–20. http://dx.doi.org/10.1210/en.2004-0515.

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Abstract Relaxin (RLN) is a small peptide hormone that affects a variety of biological processes. Rln1 knockout mice exhibit abnormal nipple development, prolonged parturition, agerelated pulmonary fibrosis, and abnormalities in the testes and prostate. We describe here RLN receptor Lgr7-deficient mice. Mutant females have grossly underdeveloped nipples and are unable to feed their progeny. Some Lgr7−/− females were unable to deliver their pups. Histological analysis of Lgr7 mutant lung tissues demonstrates increased collagen accumulation and fibrosis surrounding the bronchioles and the vascular bundles, absent in wild-type animals. However, Lgr7-deficient males do not exhibit abnormalities in the testes or prostate as seen in Rln1 knockout mice. Lgr7-deficient females with additional deletion of Lgr8 (Great), another putative receptor for RLN, are fertile and have normal-sized litters. Double mutant males have normal-sized prostate and testes, suggesting that Lgr8 does not account for differences in Rln1−/− and Lgr7−/− phenotypes. Transgenic overexpression of Insl3, the cognate ligand for Lgr8, does not rescue the mutant phenotype of Lgr7-deficient female mice indicating nonoverlapping functions of the two receptors. Our data indicate that neither Insl3 nor Lgr8 contribute to the RLN signaling pathway. We conclude that the Insl3/Lgr8 and Rln1/Lgr7 actions do not overlap in vivo.

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Xu, Qi, Edna D. Lekgabe, Xiao-Ming Gao, Ziqiu Ming, Geoffrey W. Tregear, Anthony M. Dart, Ross A. D. Bathgate, Chrishan S. Samuel, and Xiao-Jun Du. "Endogenous Relaxin Does Not Affect Chronic Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis." Endocrinology 149, no. 2 (November 8, 2007): 476–82. http://dx.doi.org/10.1210/en.2007-1220.

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The effect of endogenous relaxin on the development of cardiac hypertrophy, dysfunction, and fibrosis remains completely unknown. We addressed this question by subjecting relaxin-1 deficient (Rln1−/−) and littermate control (Rln1+/+) mice of both genders to chronic transverse aortic constriction (TAC). The extent of left ventricular (LV) remodeling and dysfunction were studied by serial echocardiography over an 8-wk period and by micromanometry. The degree of hypertrophy was estimated by LV weight, cardiomyocyte size, and expression of relevant genes. Cardiac fibrosis was determined by hydroxyproline assay and quantitative histology. Expression of endogenous relaxin during the course of TAC was also examined. In response to an 8-wk period of pressure overload, TAC mice of both genotypes developed significant LV hypertrophy, fibrosis, hypertrophy related gene profile, and signs indicating congestive heart failure when compared with respective sham controls. The severity of these alterations was not statistically different between the two genotypes of either gender. Relaxin mRNA expression was up-regulated, whereas that of its receptor was unchanged in the hypertrophic myocardium of wild-type mice. Collectively, the extent of pressure overload-induced LV hypertrophy, fibrosis, and dysfunction were comparable between Rln1+/+ and Rln1−/− mice. Thus, although up-regulated in its expression, endogenous relaxin had no significant effect on the progression of cardiac maladaptation and dysfunction in the setting of chronic pressure overload.

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Bennasar García, Miguel Israel, Vilma Del Valle Lanza Castillo, and Rainier Vicente Sánchez Camacho. "Formación docente universitaria, desde una mirada diversa y crítica de sus actores." Educación Superior, no. 30 (December 4, 2020): 11–28. http://dx.doi.org/10.56918/es.2020.i30.pp11-28.

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En el presente artículo se presentan los resultados del estudio sobre la formación docente universitaria, desde una perspectiva crítica de sus actores, cuyo objetivo fue comparar los programas de formación docente en el Recinto Luis Napoleón Núñez Molina (RLNNM), de República Dominicana y a la Universidad Pedagógica Experimental Libertador- Instituto Pedagógico de Maturín (UPEL-IPM), Venezuela. Su pertinencia e importancia se justifica, porque son los protagonistas quienes precisan las evidencias a partir de las cuales se basan los resultados. La metodología empleada fue la fenomenología, para ello se eligieron al azar 5 docentes de manera intencional, 3 del RLNNM, y 2 de la UPEL-IPM, a quienes se les aplicó un cuestionario indagatorio sobre el proceso de formación. Los principales resultados fueron: la mayoría opina que los programas, en ambas instituciones, es adecuado; existe una marcada vinculación, entre los programas de formación docente, y el entorno social. La calidad de los programas de formación, en las dos instituciones, están en una relación estrecha con los aprendizajes de los estudiantes; los discursos evidencian el predominio de una práctica pedagógica que enfatiza los resultados, en lugar de los procesos de formación y adquisición de conocimientos.

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Yu, Yongxian, and Luyong Zhang. "Adaptive Modulation Scheme for Satellite Communication Channel Based on RLNN." Journal of Physics: Conference Series 1856, no. 1 (April 1, 2021): 012053. http://dx.doi.org/10.1088/1742-6596/1856/1/012053.

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Sun, Changhui, Linchuan Liu, Jiuyou Tang, Aihong Lin, Fantao Zhang, Jun Fang, Genfa Zhang, and Chengcai Chu. "RLIN1, encoding a putative coproporphyrinogen III oxidase, is involved in lesion initiation in rice." Journal of Genetics and Genomics 38, no. 1 (January 2011): 29–37. http://dx.doi.org/10.1016/j.jcg.2010.12.001.

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Vieira, Paulo, Amy Peetz, Benjamin Mimee, Kanan Saikai, Dimitre Mollov, Ann MacGuidwin, Inga Zasada, and Lev G. Nemchinov. "Prevalence of the root lesion nematode virus (RLNV1) in populations of Pratylenchus penetrans from North America." Journal of Nematology 52 (2020): 1–10. http://dx.doi.org/10.21307/jofnem-2020-045.

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Ganguly, Koustav, Tobias Stoeger, Scott C. Wesselkamper, Claudia Reinhard, Maureen A. Sartor, Mario Medvedovic, Craig R. Tomlinson, et al. "Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein structure." Physiological Genomics 31, no. 3 (November 2007): 410–21. http://dx.doi.org/10.1152/physiolgenomics.00260.2006.

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Impaired development and reduced lung capacity are risk factors of asthma and chronic obstructive pulmonary disease. Previously, our genomewide linkage analysis of C3H/HeJ (C3H) and JF1/Msf (JF1) mouse strains identified quantitative trait loci (QTLs) associated with the complex traits of dead space volume (Vd), total lung capacity (TLC), lung compliance (Cl), and diffusing capacity for CO (DCO). We assessed positional candidate genes by comparing C3H with JF1 lung transcript levels by microarray and by comparing C3H, BALB/cByJ, C57BL/6J, A/J, PWD/PhJ, and JF1 strains, using exon sequencing to predict protein structure. Microarray identified >900 transcripts differing in C3H and JF1 lungs related to lung development, function, and remodeling. Of these, three genes localized to QTLs associated with differences in lung function. C3H and JF1 strains differed in transcript and protein levels of superoxide dismutase 3, extracellular [SOD3; mouse chromosome (mCh) 5: Vd] and transcript of trefoil factor 2 (TFF2; mCh 17: TLC and DCO), and ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2; mCh 15: TLC and Cl). Nucleotide sequencing of Sod3, Tff2, and previously identified Relaxin 1 ( Rln1; mCh 19: Cl) uncovered polymorphisms that could lead to nonsynonymous amino acid changes and altered predicted protein structure. Gene-targeted Sod3−/− mice had increased conducting airway volume (Vd/TLC) compared with strain-matched control Sod3+/+ mice, consistent with the QTL on mCh 5. Two novel genes ( Tff2 and Enpp2) have been identified and two suspected genes ( Sod3 and Rln1) have been supported as determinants of lung function in mice. Findings with gene-targeted mice suggest that SOD3 is a contributing factor defining the complex trait of conducting airway volume.

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Das, M. K., P. Bera, and P. P. Sarkar. "Oppositional Krill Herd Algorithm-Based RLNN Controller for Discrete-Mode AGC in Deregulated Hydrothermal Power System Using SMES." Iranian Journal of Science and Technology, Transactions of Electrical Engineering 42, no. 3 (June 27, 2018): 309–25. http://dx.doi.org/10.1007/s40998-018-0062-8.

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Tevz, Gregor, Sean McGrath, Ryan Demeter, Vincent Magrini, Varinder Jeet, Anja Rockstroh, Stephen McPherson, et al. "Identification of a novel fusion transcript between human relaxin-1 (RLN1) and human relaxin-2 (RLN2) in prostate cancer." Molecular and Cellular Endocrinology 420 (January 2016): 159–68. http://dx.doi.org/10.1016/j.mce.2015.10.011.

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Wu, Bo, Xinzhou Huang, Mu Zhang, and Wei Chu. "Significance of Immune-Related Genes in the Diagnosis and Classification of Intervertebral Disc Degeneration." Journal of Immunology Research 2022 (August 30, 2022): 1–15. http://dx.doi.org/10.1155/2022/2616260.

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Background. With the extensive development of intervertebral disc degeneration (IDD) research, IDD has been found to be a complex disease associated with immune-related gene (IRGs) changes. Nonetheless, the roles of IRGs in IDD are unclear. Methods. In our study, 11 IRGs were chosen using differential analysis between nondisc degeneration and degenerative patients from the GEO database. Then, we utilized a random forest (RF) model to screen six candidate IRGs to predict the risk of IDD. A nomogram was developed on the basis of six candidate IRGs, and DCA showed that patients could benefit from the nomogram. Based on the selected significant IRGs, a consensus clustering approach was used to differentiate disc degeneration patients into two immune patterns (immune cluster A and B). The PCA algorithm was constructed to compute immune scores for every sample, to quantify immune patterns. The immune scores of immune cluster B patients were higher than those of immune cluster A. Results. Through differential expression analysis between healthy and IDD samples, 11 significant IRGs (CTSS, S100Z, STAT3, KLRK1, FPR1, C5AR2, RLN1, IFGR2, IL2RB, IL17RA, and IL6R) were recognized through significant IRGs. The “Reverse Cumulative Distribution of Residual” and “Boxplots of Residual” indicate that the RF model has minimal residuals. The majority of samples in the model have relatively small residuals, demonstrating that the model is better. Besides, the nomogram model was constructed based on importance and the IRGs with importance scores greater than 2 (FPR1, RLN1, S100Z, IFNGR2, KLRK1, and CTSS). The nomogram model revealed that decision-making based on an established model might be beneficial for IDD patients, and the predictive power of the nomogram model was significant. In addition, we identified two different immune cluster patterns (immune cluster A and immune cluster B) based on the 11 IRGs. We found that immune cluster A had significantly higher levels of MDSC, neutrophil, plasmacytoid dendritic cell, and type 17 T helper cell expression than immune cluster B. And we calculated the score for each sample to quantify the gene patterns. The patients in immune cluster B or gene cluster B had higher immune scores than those in immune cluster A or gene cluster A. Conclusion. In conclusion, IRGs play an extremely significant role in the occurrence of IDD. Our study of immune patterns may guide the strategies of prevention and treatment for IDD in the future.

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Southey, Bruce R., and Sandra L. Rodriguez-Zas. "Changes in Neuropeptide Prohormone Genes among Cetartiodactyla Livestock and Wild Species Associated with Evolution and Domestication." Veterinary Sciences 9, no. 5 (May 23, 2022): 247. http://dx.doi.org/10.3390/vetsci9050247.

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The impact of evolution and domestication processes on the sequences of neuropeptide prohormone genes that participate in cell–cell signaling influences multiple biological process that involve neuropeptide signaling. This information is important to understand the physiological differences between Cetartiodactyla domesticated species such as cow, pig, and llama and wild species such as hippopotamus, giraffes, and whales. Systematic analysis of changes associated with evolutionary and domestication forces in neuropeptide prohormone protein sequences that are processed into neuropeptides was undertaken. The genomes from 118 Cetartiodactyla genomes representing 22 families were mined for 98 neuropeptide prohormone genes. Compared to other Cetartiodactyla suborders, Ruminantia preserved PYY2 and lost RLN1. Changes in GNRH2, IAPP, INSL6, POMC, PRLH, and TAC4 protein sequences could result in the loss of some bioactive neuropeptides in some families. An evolutionary model suggested that most neuropeptide prohormone genes disfavor sequence changes that incorporate large and hydrophobic amino acids. A compelling finding was that differences between domestic and wild species are associated with the molecular system underlying ‘fight or flight’ responses. Overall, the results demonstrate the importance of simultaneously comparing the neuropeptide prohormone gene complement from close and distant-related species. These findings broaden the foundation for empirical studies about the function of the neuropeptidome associated with health, behavior, and food production.

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Zhang, Jingyun, Lingyu Xu, and Baogang Jin. "SWAR: A Deep Multi-Model Ensemble Forecast Method with Spatial Grid and 2-D Time Structure Adaptability for Sea Level Pressure." Information 13, no. 12 (December 12, 2022): 577. http://dx.doi.org/10.3390/info13120577.

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The multi-model ensemble (MME) forecast for meteorological elements has been proved many times to be more skillful than the single model. It improves the forecast quality by integrating multiple sets of numerical forecast results with different spatial-temporal characteristics. Currently, the main numerical forecast results present a grid structure formed by longitude and latitude lines in space and a special two-dimensional time structure in time, namely the initial time and the lead time, compared with the traditional one-dimensional time. These characteristics mean that many MME methods have limitations in further improving forecast quality. Focusing on this problem, we propose a deep MME forecast method that suits the special structure. At spatial level, our model uses window self-attention and shifted window attention to aggregate information. At temporal level, we propose a recurrent like neural network with rolling structure (Roll-RLNN) which is more suitable for two-dimensional time structure that widely exists in the institutions of numerical weather prediction (NWP) with running service. In this paper, we test the MME forecast for sea level pressure as the forecast characteristics of the essential meteorological element vary clearly across institutions, and the results show that our model structure is effective and can make significant forecast improvements.

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Edsgärd, D., M. Scheel, N. T. Hansen, U. Ralfkiaer, T. S. Jensen, N. E. Skakkebaek, S. Brunak, R. Gupta, E. Rajpert-De Meyts, and A. M. Ottesen. "Heterozygous deletion at the RLN1 locus in a family with testicular germ cell cancer identified by integrating copy number variation data with phenome and interactome information." International Journal of Andrology 34, no. 4pt2 (June 22, 2011): e122-e132. http://dx.doi.org/10.1111/j.1365-2605.2011.01188.x.

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Gu, Hui-Ping, Sen Lin, Ming Xu, Hai-Yi Yu, Xiao-Jun Du, You-Yi Zhang, Gu Yuan, and Wei Gao. "Up-Regulating Relaxin Expression by G-Quadruplex Interactive Ligand to Achieve Antifibrotic Action." Endocrinology 153, no. 8 (June 6, 2012): 3692–700. http://dx.doi.org/10.1210/en.2012-1114.

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Myocardial fibrosis is a key pathological change in a variety of heart diseases contributing to the development of heart failure, arrhythmias, and sudden death. Recent studies have shown that relaxin prevents and reverses cardiac fibrosis. Endogenous expression of relaxin was elevated in the setting of heart disease; the extent of such up-regulation, however, is insufficient to exert compensatory actions, and the mechanism regulating relaxin expression is poorly defined. In the rat relaxin-1 (RLN1, Chr1) gene promoter region we found presence of repeated guanine (G)-rich sequences, which allowed formation and stabilization of G-quadruplexes with the addition of a G-quadruplex interactive ligand berberine. The G-rich sequences and the G-quadruplexes were localized adjacent to the binding motif of signal transducer and activator of transcription (STAT)3, which negatively regulates relaxin expression. Thus, we hypothesized that the formation and stabilization of G-quadruplexes by berberine could influence relaxin expression. We found that berberine-induced formation of G-quadruplexes did increase relaxin gene expression measured at mRNA and protein levels. Formation of G-quadruplexes significantly reduced STAT3 binding to the promoter of relaxin gene. This was associated with consequent increase in the binding of RNA polymerase II and STAT5a to relaxin gene promoter. In cardiac fibroblasts and rats treated with angiotensin II, berberine was found to suppress fibroblast activation, collagen synthesis, and extent of cardiac fibrosis through up-regulating relaxin. The antifibrotic action of berberine in vitro and in vivo was similar to that by exogenous relaxin. Our findings document a novel therapeutic strategy for fibrosis through up-regulating expression of endogenous relaxin.

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Wang, Jasmine Jiemei, Na Sun, Yi-Te Lee, Minhyung Kim, Sungyong You, Hsian-Rong Tseng, Yazhen Zhu, and Edwin Melencio Posadas. "Extracellular vesicle-based assay for detecting metastases and dynamic monitoring of prostate cancer." Journal of Clinical Oncology 40, no. 6_suppl (February 20, 2022): 182. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.182.

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182 Background: There is an unmet need to develop a noninvasive assay to detect the metastatic progression of prostate cancer (PCa) patients for timely treatment. We aim to optimize an extracellular vesicle (EV)-based Digital Scoring Assay to reflect the disease status of PCa. Methods: PCa EV Digital Scoring Assay integrated a PCa-derived EV purification device (i.e., EV Click Chip) and downstream reverse-transcription droplet digital PCR for transcriptomic profiling of PCa-derived EVs. The performance of the Assay for purifying PCa-derived EVs was assessed using artificial plasma samples with spiked EVs. In parallel, a panel of 11 PCa-relevant mRNA markers were selected and validated. PCa EV Digital Scoring Assay in conjugation with the 11-gene panel was tested using plasma from 20 localized, 20 metastatic PCa patients, and serial plasma from three PCa patients. mRNA expressions were computed using weighted Z score method. ROC analysis was utilized to distinguish localized from metastatic PCa. Results: After optimization, the capability of purifying PCa-derived EVs from artificial plasma samples by EV Click Chips (92.5 ± 5.4%) outperformed ultracentrifugation or precipitation methods (41.0 ± 3.2%; 34.9± 2.2%; P < 0.001). Eleven genes, i.e., ACP3, FOLH1, HOXB13, KLK2, KLK3, KLK4, MSMB, RLN1, SLC45A3, STEAP2, and TMPRSS, were selected using The Tissue Atlas and a gene set from a blood-based study as our panel. Strong signals of the panel were detected from three PCa cells (LNCaP, C4-2B, and 22Rv1) and their derived EVs, while rare signals were detected in either WBCs or EVs purified from male healthy donor. In the clinical study, the Z scores calculated from the selected 11-gene panel, were significantly higher in 20 metastatic PCa than 20 localized PCa with an area under the ROC curve of 0.88 (95% CI = 0.78-0.98). Lastly, longitudinal analyses of three PCa patients showed that the Z scores can reflect the clinical progression, response, and stable status, even when disease is undetectable by imaging. Conclusions: We develop a sensitive PCa EV Digital Scoring Assay to distinguish metastatic PCa and reveal the dynamic disease states in a noninvasive manner. This assay holds the potential to augment current imaging tools and tests for timely detection of PCa progression and improve care for patients.

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Quỳnh Huê, Hoàng, Trần Song Giang, and Đặng Đức Minh. "NGHIÊN CỨU CÁC RỐI LOẠN NHỊP NHĨ NHANH Ở BỆNH NHÂN MANG MÁY TẠO NHỊP VĨNH VIỄN HAI BUỒNG TRÊN 1 NĂM." Tạp chí Y học Việt Nam 504, no. 2 (August 10, 2021). http://dx.doi.org/10.51298/vmj.v504i2.907.

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Mục tiêu: Tìm hiểu đặc điểm các rối loạn nhịp nhĩ nhanh ở bệnh nhân mang máy tạo nhịp vĩnh viễn hai buồng trên 1 năm. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang 122 bệnh nhân (BN) mang máy tạo nhịp vĩnh viễn hai buồng trên 1 năm được theo dõi định kì tại Viện Tim Mạch– Bệnh viện Bạch Mai từ tháng 08/2020 đến tháng 8/2021. Kết quả: Tuổi trung bình là 62 ± 16 tuổi, nữ giới 63%, 71/ 122 bệnh nhân mang máy tạo nhịp vĩnh viễn hai buồng trên 1 năm có rối loạn nhịp nhĩ nhanh chiếm tỉ lệ 58,2% (AHRE 32,8%, rung nhĩ 25,4%). Thời gian mang máy tạo nhịp vĩnh viễn hai buồng trên 1 năm trung bình 3 ± 2 năm. Nguy cơ rối loạn nhịp nhĩ nhanh (RLNNN) tăng gấp 2,6 lần nếu bệnh nhân có suy nút xoang, và tăng gấp 0,4 lần ở bệnh nhân có phương thức tạo nhịp lúc khám DDD, với p < 0.05. Thời điểm xuất hiện AHRE , rung nhĩ trên 6 giờ đến 12 giờ sáng chiếm tỉ lệ cao nhất lần lượt là 85%, 74,2%, với p < 0.05. RLNNN thường không có triệu chứng lâm sàng 75%. Nguy cơ đột quị, TIA của nhóm AHRE > 5.5 giờ cao gấp 0,05 lần so với nhóm AHRE ≤ 5.5 giờ. Kết luận: Rối loạn nhịp nhĩ nhanh thường không có triệu chứng trên lâm sàng, biến cố tắc mạch nguy cơ xảy ra thời lượng cơn AHRE trên 5, 5 giờ với CI 95%( 0,006-0,4), p < 0,05.

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Haney, Jamie L., David S. Schwartzman, and Sanjeev G. Shroff. "Abstract 194: Relaxin Receptor-Ligand Expression in a Fibrotic Environment." Circulation Research 115, suppl_1 (July 18, 2014). http://dx.doi.org/10.1161/res.115.suppl_1.194.

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The renin-overproducing transgenic rat (mREN2) has recently been proposed as a model of left ventricular (LV) hypertension and fibrosis. Comparing mREN2 (n=7) to sex- and age-matched Wistar-Han control rats (WHAN, n=11), we have confirmed hypertension (mean blood pressure: 174±9 vs. 107±3 mmHg, P<0.001), hypertrophy (LV weight:body weight: 4.0±0.1 vs. 2.7±0.1 mg/g, P<0.001), and cardiac fibrosis. At the protein level, LV from mREN2 exhibited significantly higher percentage of interstitial collagen per total protein area versus WHAN (5.95±1.01% vs. 1.96±0.06%, P=0.02). At the level of LV function, mREN2 hearts demonstrated significant diastolic dysfunction (increased stiffness coefficient from stress-strain relationship: 198±30 vs. 78±10, P=0.01, and reduced magnitude of dP/dtmin: 1254±125 vs. 2000±110 mmHg/s, P<0.001), and impaired relaxation (increased relaxation time constant: 0.048±0.001 vs. 0.043±0.001 s, P=0.002). The naturally occurring hormone relaxin is known to have antifibrotic properties in multiple organ systems and it affects both synthesis and degradation aspects of collagen homeostasis. It is known that relaxin (RLN1) and receptor (RXFP1) are expressed locally in LV tissue, yet the biological function of the endogenous relaxin message-receptor system is not fully understood. Interestingly, the relative mRNA expressions of relaxin and relaxin receptor were increased in this model of LV fibrosis (2-ΔΔCT by qRT-PCR for RLN1: 3.04±0.56 (mREN2) vs. 1.0±0.18 (WHAN), P=0.001; and RFXP1: 7.06±1.57 (mREN2) vs. 1.00±0.20 (WHAN), P=0.003). Thus, the unregulated endogenous relaxin-receptor system in the mREN2 fibrosis model seems to be an adaptive response which is trying to keep the fibrosis in check. However, this endogenous adaptive response is insufficient to completely block collagen accumulation and prevent LV diastolic dysfunction. We are currently conducting experiments to examine whether exogenous administration of relaxin can assist the endogenous adaptive response and reverse LV fibrosis and normalize diastolic function in this model.

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Das, Milton Kumar, Parthasarathi Bera, and Partha Pratim Sarkar. "PID‐RLNN controllers for discrete mode LFC of a three‐area hydrothermal hybrid distributed generation deregulated power system." International Transactions on Electrical Energy Systems 31, no. 5 (March 16, 2021). http://dx.doi.org/10.1002/2050-7038.12837.

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Jin, Xin, Jun Wang, Lina Ge, and Qing Hu. "Identification of Immune-Related Biomarkers for Sciatica in Peripheral Blood." Frontiers in Genetics 12 (December 2, 2021). http://dx.doi.org/10.3389/fgene.2021.781945.

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Objective: Sciatica pertains to neuropathic pain that has been associated with inflammatory response. We aimed to identify significant immune-related biomarkers for sciatica in peripheral blood.Methods: We utilized the GSE150408 expression profiling data from the Gene Expression Omnibus (GEO) database as the training dataset and extracted immune-related genes for further analysis. Differentially expressed immune-related genes (DEIRGs) between healthy controls and patients with sciatica were selected using the “limma” package and verified in clinical specimens by quantitative reverse transcription PCR (RT-qPCR). A diagnostic immune-related gene signature was established using the training model and random forest (RF), generalized linear model (GLM), and support vector machine (SVM) models. Sciatica patient subtypes were identified using the consensus clustering method.Results: Thirteen significant DEIRGs were acquired, of which five (CRP, EREG, FAM19A4, RLN1, and WFIKKN1) were selected to establish a diagnostic immune-related gene signature according to the most appropriate training model, namely, the RF model. A clinical application nomogram model was established based on the expression level of the five DEIRGs. The sciatica patients were divided into two subtypes (C1 and C2) according to the consensus clustering method.Conclusions: Our research established a diagnostic five immune-related gene signature to discriminate sciatica and identified two sciatica subtypes, which may be beneficial to the clinical diagnosis and treatment of sciatica.

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Journal articles on the topic 'Rlnn1'

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