Dissertations / Theses: 'Risk analysis results'

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Tillquist, Christopher R. "The Moment of Truth: An Analysis of the Physician/Client Interaction and Interpretation of Test Results." University of Arizona, Department of Anthropology, 1998. http://hdl.handle.net/10150/110193.

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The relationships between health, the scientific approach in medicine and concepts of epidemiology underlie theoretical and cultural attitudes of the nature of behavior and health risks. Medical tests that diagnose risk factors are thought to be predictive of disease. Physicians employ these tests to more accurately assess the health of their patients and convince their charges to change their behaviors. Communication of newly described risk factors is challenging for both physicians and patients as each party negotiates modifications of behavior and perceptions of reality.

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Lindgren, Margareta. "Pressure sores : risk assessment and prevention /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med784s.pdf.

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Fiala, Oliver, and Danny Wende. "The impact of trust, risk and disaster exposure on microinsurance demand: Results of a DCE analysis in Cambodia." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-203561.

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Natural disasters are increasing in frequency and intensity and have devastating impacts on individuals, both humanitarian and economic, particularly in developing countries. Microinsurance is seen as one promising instrument of disaster risk management, however the level of demand for respective projects remains low. Using behavioural games and a discrete choice experiment, this paper analyses the demand for hypothetical microinsurance products in rural Cambodia and contributes significant household level evidence to the current research. A general preference for microinsurance can be found, with demand significantly affected by price, provider, requirements for prevention and combinations with credit. Furthermore, financial literacy, risk aversion, levels of trust and previous disaster experience impact the individual demand for flood insurance in rural Cambodia.

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Quan, Yongxin. "Risk perceptions, importance ranking and a contingency valuation analysis: results from a survey of Quebec producers on farm environmental management." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18204.

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This research studied Quebec producers’ environmental attitudes and perceptions on environmentally friendly practices on farm, such as an environmental management system (EMS), using a survey. The contingency valuation method (CVM) was applied to elicit producers’ mean willingness to accept compensation (WTA) of adopting an EMS on farm, in terms of the percentage of direct costs of implementation. Factors affecting the mean WTA were studied to examine their influences. The results show that Quebec producers adopt environmental practices extensively and face many challenges in agro-environmental management. The results also show that producers have mixed perceptions in the benefits and difficulties of environmentally friendly practices and a negative attitude towards environmental regulations. The mean WTA of Quebec producers is estimated at 79.73%. French speaking and English speaking farmers have the mean WTA of 79.91% and 71.75%, respectively. The regression analysis identifies that producers’ knowledge level on EMS, their attitudes towards the benefits and difficulties, internet access and the use of a computer in farm management are significant variables with respect to the mean WTA.
Cette recherche a pour but l’étude de la perception et l’attitude des producteurs agricoles du Québec sur les pratiques culturales respectueuses de l’environnement tel que le système de la gestion environnementale (SGE) à partir d’un sondage. La méthode l’evaluation contingente est utilisée afin de mesurer la volonté d’accepté la compensation (VAC) d’adopter le systeme de gestion environnementale au sein de l’entreprise en terme de pourcentage de coûts directs d’adoption comme compensation. Dans cette recherche, les facteurs influençant la moyenne de la VAC seront étudiés. Les résultats de l’analyse montrent que bon nombre de producteurs québécois adoptent déjà les pratiques respectueuses de l’environnement et font face à de nombreux défis en gestion agro-environnementale. Ces résultats montrent également que les producteurs confondent leur perception concernant les avantages et les difficultés des pratiques culturales respectueuses de l’environnement et une attitude peu négative envers les lois environnementales. La moyenne de la VAC des agriculteurs québécois est estimé à 79,73%. Les agriculteurs francophones démontre une VAC de 79,91% alors que celui des agriculteurs anglophones est de 71,75%, respectivement. D’après cette étude, le niveau de connaissance des agriculteurs sur le SGE, leurs attitudes envers les avantages et difficultés, l’accès à l’internet et l’usage d’un ordinateur dans la gestion de l’entreprise sont des facteurs significatifs qui influencent la moyenne de la VAC. fr

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Kaymaz, N., M. Drukker, Roselind Lieb, Hans-Ulrich Wittchen, N. Werbeloff, M. Weiser, T. Lataster, and Os J. van. "Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-117329.

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Background The base rate of transition from subthreshold psychotic experiences (the exposure) to clinical psychotic disorder (the outcome) in unselected, representative and non-help-seeking population-based samples is unknown. Method A systematic review and meta-analysis was conducted of representative, longitudinal population-based cohorts with baseline assessment of subthreshold psychotic experiences and follow-up assessment of psychotic and non-psychotic clinical outcomes. Results Six cohorts were identified with a 3–24-year follow-up of baseline subthreshold self-reported psychotic experiences. The yearly risk of conversion to a clinical psychotic outcome in exposed individuals (0.56%) was 3.5 times higher than for individuals without psychotic experiences (0.16%) and there was meta-analytic evidence of dose–response with severity/persistence of psychotic experiences. Individual studies also suggest a role for motivational impairment and social dysfunction. The evidence for conversion to non-psychotic outcome was weaker, although findings were similar in direction. Conclusions Subthreshold self-reported psychotic experiences in epidemiological non-help-seeking samples index psychometric risk for psychotic disorder, with strong modifier effects of severity/persistence. These data can serve as the population reference for selected and variable samples of help-seeking individuals at ultra-high risk, for whom much higher transition rates have been indicated.

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Kaymaz, N., M. Drukker, Roselind Lieb, Hans-Ulrich Wittchen, N. Werbeloff, M. Weiser, T. Lataster, and Os J. van. "Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results." Technische Universität Dresden, 2012. https://tud.qucosa.de/id/qucosa%3A27014.

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Background The base rate of transition from subthreshold psychotic experiences (the exposure) to clinical psychotic disorder (the outcome) in unselected, representative and non-help-seeking population-based samples is unknown. Method A systematic review and meta-analysis was conducted of representative, longitudinal population-based cohorts with baseline assessment of subthreshold psychotic experiences and follow-up assessment of psychotic and non-psychotic clinical outcomes. Results Six cohorts were identified with a 3–24-year follow-up of baseline subthreshold self-reported psychotic experiences. The yearly risk of conversion to a clinical psychotic outcome in exposed individuals (0.56%) was 3.5 times higher than for individuals without psychotic experiences (0.16%) and there was meta-analytic evidence of dose–response with severity/persistence of psychotic experiences. Individual studies also suggest a role for motivational impairment and social dysfunction. The evidence for conversion to non-psychotic outcome was weaker, although findings were similar in direction. Conclusions Subthreshold self-reported psychotic experiences in epidemiological non-help-seeking samples index psychometric risk for psychotic disorder, with strong modifier effects of severity/persistence. These data can serve as the population reference for selected and variable samples of help-seeking individuals at ultra-high risk, for whom much higher transition rates have been indicated.

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Blázquez, Navarro Arturo. "Towards personalized medicine in kidney transplantation: Unravelling the results of a large multi-centre clinical study." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21322.

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Trotz Fortschritte in den letzten Dekaden ist das Langzeitüberleben von Nierentransplantaten unzureichend. Die Personalisierung der Behandlung kann dabei zu erheblichen Verbesserungen führen. Vor diesem Hintergrund wurde eine Kohorte von 587 Patienten im ersten Jahr nach der Transplantation untersucht und ein breites Spektrum von Markern zur langfristigen Prognose etabliert. In dieser Dissertation beschreibe ich in vier Manuskripten und zwei Kapiteln meine Arbeit zur personalisierten Transplantationsmedizin. Der klinische Verlauf von Patienten nach Nierentransplantation wurde untersucht. Die wichtigen Komplikationen standen im Vordergrund: Virusreaktivierungen – insbesondere die BK- und Cytomegalieviren – und akute Abstoßung. Folgende Analysen wurden durchgeführt: (i) Systematische Analyse der Assoziationen zwischen Virusreaktivierungen und deren Einfluss auf das Transplantationsergebnis; (ii) Bewertung der Auswirkungen antiviraler Behandlungsstrategien auf die Transplantationsergebnisse; (iii) Entwicklung eines Tools zur Prätransplantations-Risikoeinschätzung der Abstoßung und (iv) Erstellung eines mathematischen Modells für die personalisierte Charakterisierung der Immunantwort gegen das BK-Virus. Zusammengenommen haben die vier Studien das Potenzial, (i) die Patientenversorgung zu verbessern, (ii) die Überwachung von Virusreaktivierungen zu optimieren, (iii) Präventionsstrategien gegen virale Reaktivierungen zu stratifizieren, (iv) die Behandlung der Patienten an das individuelle Risiko akuter Abstoßung anzupassen, und (v) zur Personalisierung der Immuntherapie beizutragen. Die Studien zeigen, wie das große Datenvolumen einer klinischen Studie zur Weiterentwicklung der personalisierten Medizin unter Einsatz effektiver Strategien für Datenmanagement, Analyse und Interpretation genutzt werden kann. Es ist zu erwarten, dass diese Ergebnisse die klinische Praxis beeinflussen und so das langfristige Überleben und die Lebensqualität der Patienten verbessern.
In spite of the developments in the last decades, long-term graft survival rates in kidney transplantation are still poor: Personalization of treatment can thereby lead to a drastic improvement in long-term outcomes. With this goal, a cohort of 587 patients was characterized for a wide range of markers during the first post-transplantation year to assess their long-term prognosis. Here, I describe along four manuscripts and two chapters my work on personalized medicine for renal transplantation. In detail, we have studied the clinical evolution of patients with emphasis on two most relevant complications: viral reactivations – particularly those of BK virus and cytomegalovirus – and acute rejection. We have analysed in depth these phenomena by (i) exhaustively analysing the associations between different viral reactivations and their influence on transplantation outcome, (ii) evaluating the effects of antiviral treatment strategies on viral reactivation and other transplantation outcomes with emphasis on sex-associated differences, (iii) developing a tool for the pre-transplantation risk assessment of acute cellular rejection, and (iv) creating a mathematical model for the personalized characterization of the immune response against the BK virus under immunosuppression. Taken together, these studies have the potential of improving patient care, optimizing monitoring of viral reactivations, stratifying antiviral prevention strategies, tailoring immunosuppression and monitoring to the individual risk of acute rejection, and contributing to personalization of immunotherapy. They demonstrate how the large volume of data obtained within a clinical study can be employed to further the development of personalized medicine, employing effective data management, analysis and interpretation strategies. We expect these results to eventually inform clinical practice, thereby improving long-term survival and quality of life after kidney transplantation.

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Taylor, Jean. "Birth weight and acute childhood leukemia : a meta-analysis of observational studies /." Download the dissertation in PDF, 2005. http://www.lrc.usuhs.mil/dissertations/pdf/Taylor2005.pdf.

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Skinner, Michael A. "Hapsite® gas chromatograph-mass spectrometer (GC/MS) variability assessment /." Download the thesis in PDF, 2005. http://www.lrc.usuhs.mil/dissertations/pdf/Skinner2005.pdf.

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Firmin, Édouard. "Démarches cindyniques en médecine générale : proposition d'une méthode pour élaborer une conduite à tenir pour chaque "résultat de consultation" du "Dictionnaire de la Société française de médecine générale" : test de faisabilité sur "arthopathie-périarthropathie", "dépression", "réaction à situation éprouvante", "rhinite", "toux"." Poitiers, 2016. http://nuxeo.edel.univ-poitiers.fr/nuxeo/site/esupversions/57cba4cf-3fae-45dd-8f10-c6da9623e4f4.

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Introduction : Dans 70% des cas, le médecin généraliste se trouve à la fin de la consultation en situation d'incertitude diagnostique. Il doit rester vigilant face aux deux dangers qui le préoccupe : celui de faire une erreur diagnostique et celui de passer à côté d'une maladie grave. Le concept de résultat de consultation (RC) permet de caractériser les situations cliniques les plus fréquentes, de les nommer précisément et d'ainsi maitriser le premier danger. Notre travail s'est attaché à la gestion du second danger, celui de passer à côté d'une maladie grave. Nous avons tenté de répondre, en créant une méthode de gestion du risque nommée démarche cindynique, à la question suivante : est-il possible de rédiger des démarches cindyniques, adaptées aux situations cliniques les plus fréquentes en médecine générale ? Matériels et méthodes : Le travail a été encadré par un groupe de huit médecins, et s'est déroulé en quatre étapes : une revue de la littérature, l'élaboration d'une méthode de création des démarches cindyniques, son application à 20 RC, puis son évaluation auprès de 785 médecins généralistes, à l'aide d'une échelle de Likert. Résultats : Nous avons dans ce travail, élaboré les démarches cindyniques de 5 des 20 RC : "arthopathie-périarthropathie", "dépression", "réaction à situation éprouvante", "rhinite" et "toux". L'analyse de l'évaluation de ces démarches met en évidence une adhésion des médecins. Les ¾ notent l'intérêt de ces démarches à plus de 7/9 et 84% les trouvent applicables dans la pratique quotidienne avec une note supérieure à 7/9. Les médecins utilisant le Dictionnaire des résultats de consultation® (DRC), donnent globalement de meilleures appréciations. Conclusion : La création de ces démarches cindyniques est faisable et son accueil auprès des médecins généralistes favorable. Les étapes suivantes seront l'élargissement de ce travail à tout le DRC, puis à la gestion de la polypathologie, cœur de notre métier
Introduction: In 70% of cases, the general practitioner ends up in a situation of diagnostic uncertainty at the end of a consultation. He must remain vigilant concerning two dangers: in one hand, making a mistake in the diagnosis, and on the other, failing to detect a serious disease. The “résultat de consultation” (RC) concept helpsdefine the most frequent clinical situations, to designate them precisely and thus control the first danger. We focused our work on managing the second danger; that is to say, failing to detect a serious disease. By creating a risk management method called “démarches cindyniques“, we tried to answer the following question: Is it possible to draft approaches to risk analysis that are adapted to the most frequent clinical situations in general medicine? Materials and methods : The work has been carried out by a group of eight general practitioners, and has been divided into four steps: a thorough review of articles, the development of a method to create approaches to risk analysis, their application to 20 CRs, and lastly, its evaluation done by 785 general practitioners using the Likert scale. Results: Through this work, we developed theapproaches of risk analysis of 5 out of the 20 RC: "arthopathie-périarthropathie", "dépression", "réaction à situation éprouvante", "rhinite" and "toux". The analysis of the approaches' evaluations shows an extensive support from the general practitioners. Three-quarters of them evaluate the interest of these approaches at 7/9 and 84% find them useful in their daily work, rating their interest over 7/9. General practitioners using the Dictionnaire des Résultats de consultation® (DRC) generally give better evaluations. Conclusion: The creation of these approaches to risk analysis is feasible and is widely welcomed by general practitioners. The next steps will be the generalization of this method for the whole DRC and then forpolypathology which represents the core of our profession

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Larabi, Islam Amine. "Nouveaux produits de synthèse : analyse, consommation et métabolisme ; Applications cliniques et médicolégales Rapid and simultaneous screening of new psychoactive substances and conventional drugs of abuse. A comparative study of Biochip Array Technology versus LC-MS/MS in whole blood and urine Development of a sensitive untargeted liquid chromatography– high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances Validation of an UPLC-MS/MS method for the determination of sixteen synthetic cannabinoids in human hair. Application to document chronic use of JWH-122 following a non-fatal overdose Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samples Prevalence and Surveillance of Synthetic Cathinones Use by Hair Analysis: An Update Review Prevalence of New Psychoactive Substances(NPS) and conventional drugs of abuse (DOA) in high risk populations from Paris(France) and its suburbs A cross sectional study by hair testing(2012–2017) Evaluation of drug abuse by hair analysis and self-reported use among MSM under PrEP: Results from a sub-study of the ANRS-IPERGAY trial. Hair testing for 3‑fluorofentanyl, furanylfentanyl, methoxyacetylfentanyl, carfentanil, acetylfentanyl and fentanyl by LC–MS/MS after unintentional overdose Drug‐facilitated sexual assault (DFSA) involving 4‐methylethcathinone (4‐MEC),3,4‐Methylenedioxypyrovalerone (MDPV), and doxylamine highlighted by hair analysis Metabolic Profiling of Deschloro-N-ethyl-ketamine (O-PCE) and identification of new target metabolites in urine and hair using human liver microsomes and high-resolution accurate mass spectrometry." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL029.

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L’objectif de ce travail a été de développer deux approches analytiques dédiées à l’analyse toxicologique des nouveaux produits de synthèse (NPS) dans différentes matrices biologiques (sang, urine et cheveux). La première est basée sur le criblage non ciblé par chimiluminescence sur biopuces et chromatographie liquide couplée à la spectrométrie de masse haute résolution (LC-HRMS) et la deuxième correspond à un criblage ciblé par spectrométrie de masse en tandem (LC-MS/MS). Ces deux approches ont ensuite été appliquées dans des études observationnelles pour évaluer la consommation de NPS dans des populations à risques de surdosage, de pharmacodépendance ou de soumission chimique dans un contexte clinique ou médico-judiciaire.La dernière partie a été consacrée au développement d’un nouvel outil analytique de traitement des données issues de la LC-HRMS qui a permis d’étudier le métabolisme de 9 NPS in vitro sur des cultures de microsomes du foie humain (HLM) et in vivo sur des échantillons biologiques d’usagers de ces drogues. Cette dernière approche a permis la création d’une bibliothèque de spectres de haute résolution composée de 228 métabolites dont certains ont été proposés comme marqueurs pertinents d’exposition aux NPS dont ils sont issus.Ce travail a été concrétisé par la rédaction de 10 publications scientifiques et a permis d’initier plusieurs collaborations pluridisciplinaires
The aim of the present work was to develop two analytical approaches dedicated to the analysis of new psychoactive substances in different biological matrices (blood, urine and hair). The first approach is based on untargeted screening by both biochip array technology chemiluminescence assay and liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) and the second corresponds to a targeted screening by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). These two approaches were then applied in observational studies to assess the consumption of NPS in high risk populations (overdose, drug abuse, drug facilitated crimes) in clinical and forensic settings. The last part of the work was devoted to the development of a new analytical tool for LC-HRMS data processing which made it possible to study the metabolism of 9 NPS In vitro on human liver microsomes (HLM) and In vivo in biological samples from drug users. This approach has enabled the creation of HRMS spectral library containing 228 metabolites, some of which have been proposed as relevant markers of NPS exposure.This work has resulted on 10 scientific publications and allowed to initiate many multidisciplinary collaborations

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Hamy, Anne-Sophie. "Identification of Factors Predicting Sensitivity or Resistance to Neoadjuvant Chemotherapy in Breast Cancer Neoadjuvant treatment : the future of patients with breast cancer Neoadjuvant treatment for intermediate/high-risk HER2-positive and triple-negative breast cancers: no longer an “option” but an ethical obligation Long-term outcome of the REMAGUS 02 trial, a multicenter randomised phase II trial in locally advanced breast cancer patients treated with neoadjuvant chemotherapy with or without celecoxib or trastuzumab according to HER2 status BIRC5 (survivin) : a pejorative prognostic marker in stage II/III breast cancer with no response to neoadjuvant chemotherapy Beyond Axillary Lymph Node Metastasis, BMI and Menopausal Status Are Prognostic Determinants for Triple-Negative Breast Cancer Treated by Neoadjuvant Chemotherapy Pathological complete response and prognosis after neoadjuvant chemotherapy for HER2-positive breast cancers before and after trastuzumab era: results from a real-life cohort The presence of an in situ component on pre-treatment biopsy is not associated with response to neoadjuvant chemotherapy for breast cancer Chemosensitivity, tumor infiltrating lymphocytes (TILs), and survival of postpartum PABC patients treated by neoadjuvant chemotherapy Lymphovascular invasion after neoadjuvant chemotherapy is strongly associated with poor prognosis in breast carcinoma New insight for pharmacogenomics studies from the transcriptional analysis of two large-scale cancer cell line panels Biological network-driven gene selection identifies a stromal immune module as a key determinant of triple-negative breast carcinoma prognosis A Stromal Immune Module Correlated with the Response to Neoadjuvant Chemotherapy, Prognosis and Lymphocyte Infiltration in HER2-Positive Breast Carcinoma Is Inversely Correlated with Hormonal Pathways Stromal lymphocyte infiltration after neoadjuvant chemotherapy is associated with aggressive residual disease and lower disease-free survival in HER2-positive breast cancer Interaction between molecular subtypes, stromal immune infiltration before and after treatment in breast cancer patients treated with neoadjuvant chemotherapy COX2/PTGS2 Expression Is Predictive of Response to Neoadjuvant Celecoxib in HER2-negative Breast Cancer Patients Celecoxib With Neoadjuvant Chemotherapy for Breast Cancer Might Worsen Outcomes Differentially by COX-2 Expression and ER Status: Exploratory Analysis of the REMAGUS02 Trial Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS129.

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La chimiothérapie néoadjuvante (CNA) est utilisée dans les cancers du sein agressifs ou localement avancés (CS). Au delà des bénéfices cliniques, elle représente une opportunité pour monitorer in vivo la sensibilité d’une tumeur à un traitement.A partir de l’analyse de sets de données de patients traités par CNA, nous souhaitons identifier des mécanismes associes à la résistance ou sensibilité au traitement. Dans la première partie, nous avons évalué des paramètres, cliniques, anatomopathologiques et transcriptomiques. Nous avons démontré que des éléments non explorés comme la présence d’embols après CNA revêtaient une information pronostique importante. Dans une 2ème partie, nous avons analysé l’impact de l’infiltrat immunitaire dans le cancer du sein, et avons décrit les changements observés entre des échantillons avant et après CNA. Nous avons montré que l’impact pronostique des TILs était différent avant et après CNA, et était opposé dans les CS triple négatif ou HER2-positif. Finalement, nous avons analysé l’impact des comédications pendant la CNA. Nous avons trouvé des effets positifs – via l’augmentation de l’infiltrat immunitaire et la réponse au traitement – et des effets négatifs avec des effets délétères dans certains sous groupes de patients. En conclusion, la situation néoadjuvante représente une plateforme pour générer et potentiellement valider des hypothèses de recherche. La mise à disposition de jeux de données de patients traités par chimiothérapie néoadjuvante constituerait une ressource majeure pour accélérer la recherche contre le cancer du sein
Neoadjuvant chemotherapy (NAC i.e. chemotherapy before surgery) is increasingly being used for aggressive or locally advanced breast cancer (BCs). Beyond clinical benefits, it represents an opportunity to monitor in vivo sensitivity to treatment. Based on the analysis of datasets of BCs patients treated with NAC, we aimed at identifying mechanisms associated with resistance or sensitivity to treatment.In the first part, we evaluated biological, clinical, pathological and transcriptomic patterns. We demonstrated that unexplored pathological features such as post-NAC lymphovascular invasion may carried an important prognostic information.In a second part, we analyzed impact of imune infiltration in BC and we described extensively the changes of tumor infiltrating lymphocytes (TILs) between pre and post-NAC samples. We showed that the prognostic impact of TILs was different before and after NAC, and was opposite in TNBC and HER2-positive BCs. Finally, we investigated the impact of comedications use during NAC. We found both positive effects - while enhancing immune infiltration and response to treatment - and negative effects with deleterisous oncologic outcomes in specific patients subgroups. In conclusion, the neoadjuvant setting represents a platform to both generate and potentially validate research hypotheses aiming at increasing the efficacy of treatment. The public release of real-life datasets of BC patients treated with NAC would represent a major resource to accelerate BC research

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Bubláková, Petra. "Výběr informačního systému pro firmu." Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-433382.

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Fujdiak, Radek. "Analýza a optimalizace datové komunikace pro telemetrické systémy v energetice." Doctoral thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2017. http://www.nusl.cz/ntk/nusl-358408.

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Telemetry system, Optimisation, Sensoric networks, Smart Grid, Internet of Things, Sensors, Information security, Cryptography, Cryptography algorithms, Cryptosystem, Confidentiality, Integrity, Authentication, Data freshness, Non-Repudiation.

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Jones, Amy C. "What toxicologists and risk assessors think about hormesis: Results of a knowledge and opinion survey." 2010. https://scholarworks.umass.edu/dissertations/AAI3397712.

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Hormesis is a nonlinear dose-response characterized by biological responses at low doses that are opposite to those observed at higher doses. Studies and review articles on hormesis are being published at an increasing rate by researchers from diverse disciplines and debate has emerged over the role hormesis in risk assessment. As a result, a survey was conducted to assess toxicologists and risk assessors knowledge and attitudes about the hormesis dose response. Study goals were to: (1) ascertain attitudes towards hormesis and other dose-response models, (2) identify whether acceptance or rejection of hormesis is based on knowledge of hormesis, predisposing values, or demographic characteristics, and (3) evaluate potential for response bias. The survey consisted of 44 questions pre-tested by 25 toxicologists and risk assessors. The survey was distributed via email to the membership of the Society of Toxicology and the Society for Risk Analysis, 9,500 potential respondents. The overall response rate was 17% (n= 1,463) with a completion rate over 87%. Major findings were that 50% of respondents indicated sufficient data exist to support the view hormesis occurs across a wide range of species and endpoints, 59% indicated evaluating potential benefits due to hormesis should be included in risk assessments, and 65% are in favor of modifying hazard assessment protocols to identify the presence of hormesis. Respondent characteristics such as: years of experience, society membership, education, residence, employment (excluding government and pharmaceutical companies), and political, economic or social views had little influence on opinion. One of the largest positive influences was experience with hormesis based on actual research; 79% of subjects who reported observing hormesis commonly in their studies agreed hormesis is broadly generalizable. The influence of non-response bias was evaluated through several internal and external measures. Despite a lower than hoped for response rate, but because of robust external validity measures, it is concluded that respondents’ opinions are likely a reasonable representation of the societies of which they are members. Because this is a baseline survey, a follow-up survey is in order. Future survey design should separately evaluate the science of dose-response from the regulatory approach to risk assessment.

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Zervos, Andrew Peter. "A Latent Class Analysis of Vaping, Substance Use and Asthma Among U.S. High School Students: Results from the Center for Disease Control's Youth Risk Behavior Survey." Thesis, 2021. http://dx.doi.org/10.7912/C2/36.

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Indiana University-Purdue University Indianapolis (IUPUI)
Rates of vaping among high school students have increased significantly over the past decade. Prior research has found significant associations between youth vaping and substance use. However, little is known about how vaping is associated with various patterns of polysubstance use and asthma in youth. We aimed to identify how youth are best categorized into classes based on co-occurring vaping and polysubstance use behaviors, how these classes are associated with youth background and demographic characteristics, and if these classes significantly predict asthma outcomes. Our sample consisted of nationally representative data from the 2017 and 2019 waves of the Youth Risk Behavior Survey (N = 28,442). We utilized Latent Class Analysis, multinomial logistic regression analyses, and binary logistic regression analyses to examine relationships between youth vaping, polysubstance use, and asthma. Three latent classes of substance use were identified: Polysubstance Users, Lifetime Alcohol and Vape Users, and Abstainers. Age, gender, grade and race were all significantly associated with odds of membership in the Polysubstance Users class, compared to the Abstainers class. Sexual identity was not associated with class membership. Membership in the Polysubstance Users class was significantly associated with higher odds of asthma, as compared to membership in the other two classes. These findings indicate that recent vaping is associated with high probabilities of recent polysubstance use. They also suggest that youth with high probabilities of vaping and polysubstance use are at significantly high risk for asthma compared to other classes vi of youth users and non-users. We recommend that future youth intervention strategies be tailored differently toward different classes of substance use and vaping. Future research should examine how the classes of vaping and substance use that we identify emerge in youth and what social factors (e.g., peer behavior, parental connectedness, etc.) influence their development.

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Aghaei, Omid. "THE EAST PACIFIC RISE CRUSTAL THICKNESS, MOHO TRANSITION ZONE CHARACTER AND OFF-AXIS MAGMA LENS MELT CONTENT FROM 9°37.5’N TO 9°57’N: RESULTS FROM THREE-DIMENSIONAL MULTICHANNEL SEISMIC DATA ANALYSIS." 2013. http://hdl.handle.net/10222/40065.

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This thesis discusses the results from the first multi-source and multi-streamer three-dimensional multichannel seismic experiment conducted over a mid-ocean ridge environment. Prestack time migration was applied to the dataset resulting in the most detailed reflection images of a spreading center and its flanks to date. The key products from this work are maps of crustal velocities, crustal thickness, and Moho transition zone (MTZ) reflection character for a section of the fast-spreading East Pacific Rise (EPR) from 9°37.5’N to 9°57’N, excluding the area from 9°40’N to 9°42’N where no data were collected. Moho reflections were imaged within ~92% of the study area. The derived average crustal thickness and average crustal velocity for the investigated ~880 km2 area are 5920±320 m and 6320±290 m/s, respectively. The average crustal thickness varies little from Pacific to Cocos plate suggesting mostly uniform crustal production in the last ~180 Ka. Detailed analysis of the crustal thickness and MTZ reflection character shows that the third-order segmentation is governed by melt extraction processes within the uppermost mantle while the fourth-order ridge segmentation arises from mid- to upper-crustal processes. This analysis also suggests that both the mechanism of lower-crustal accretion and the volume of melt delivered to the crust vary along the investigated section of the EPR. More efficient mantle melt extraction is inferred at latitudes from 9°42’N to 9°51.5’N, with greater proportion of the lower crust accreted from the AML than for the rest of the study area. Larger volume of melt is delivered to the crust from 9°37.5’N to 9°40’N than to the investigated crust further north. At some locations, the Moho reflections are for the first time unambiguously imaged below the AML away from any ridge discontinuity suggesting that the Moho is formed at zero age at least at some sections of the spreading centers. The first study of the melt content of mid-crustal off-axis magma lenses (OAML), done using amplitude variation with offset technique calibrated for a magmatic plumbing system, shows that these magma bodies contain 0 to 20% melt. This suggests that OAMLs likely contribute little to the overall crustal formation.

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cheng-yang, Chin, and 秦正楊. "A Comparison and Analysis among Investors, Personality Traits, Perception Risk, Hedgig Behavior,and Wealth Result of Investement Linked Insurance Products-A case Study Of Foreign Owned Bank´s and Domestic Bank´s Investors." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/54939174995228600974.

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碩士
大葉大學
國際企業管理學系碩士在職專班
97
This research main purpose is discusses the investment chit to invest everybody Gutt archery target difference whether to penetrate takes refuge from danger the behav-ior to affect the wealth effect, will its consciousness risk, whether there is take refuge from danger between the behavior and the wealth effect the relevance. But investor's consciousness risk whether can affect takes refuge from danger the behavior, as well as personality special characteristic difference whether to have the different wealth effect. This research uses the questionnaire (questionnaires survey) the way, altogether sends out 500 questionnaire, recycling effective questionnaire 305, the effective returns-ratio is 61%. This research discovered after the empirical study result: The personality special characteristic to takes refuge from danger the behavior, the wealth effect to present the remarkable forward influence; Consciousness risk to takes refuge from danger the be-havior to present the remarkable forward influence; However actually not presents the remarkable influence to the wealth effect; Takes refuge from danger the behavior to pre-sent the remarkable forward influence to the wealth effect.

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Roorda, L. D., J. R. Green, A. Houwink, Pamela J. Bagley, J. Smith, I. W. Molenaar, and A. C. Geurts. "Item hierarchy-based analysis of the Rivermead Mobility Index resulted in improved interpretation and enabled faster scoring in patients undergoing rehabilitation after stroke." 2012. http://hdl.handle.net/10454/6163.

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OBJECTIVE: To enable improved interpretation of the total score and faster scoring of the Rivermead Mobility Index (RMI) by studying item ordering or hierarchy and formulating start-and-stop rules in patients after stroke. DESIGN: Cohort study. SETTING: Rehabilitation center in the Netherlands; stroke rehabilitation units and the community in the United Kingdom. PARTICIPANTS: Item hierarchy of the RMI was studied in an initial group of patients (n=620; mean age +/- SD, 69.2+/-12.5y; 297 [48%] men; 304 [49%] left hemisphere lesion, and 269 [43%] right hemisphere lesion), and the adequacy of the item hierarchy-based start-and-stop rules was checked in a second group of patients (n=237; mean age +/- SD, 60.0+/-11.3y; 139 [59%] men; 103 [44%] left hemisphere lesion, and 93 [39%] right hemisphere lesion) undergoing rehabilitation after stroke. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Mokken scale analysis was used to investigate the fit of the double monotonicity model, indicating hierarchical item ordering. The percentages of patients with a difference between the RMI total score and the scores based on the start-and-stop rules were calculated to check the adequacy of these rules. RESULTS: The RMI had good fit of the double monotonicity model (coefficient H(T)=.87). The interpretation of the total score improved. Item hierarchy-based start-and-stop rules were formulated. The percentages of patients with a difference between the RMI total score and the score based on the recommended start-and-stop rules were 3% and 5%, respectively. Ten of the original 15 items had to be scored after applying the start-and-stop rules. CONCLUSIONS: Item hierarchy was established, enabling improved interpretation and faster scoring of the RMI.

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Dissertations / Theses on the topic 'Risk analysis results'

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