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Rombaux, P., and P. W. Hellings. "Rinite cronica non allergica." EMC - Otorinolaringoiatria 13, no. 4 (December 2014): 1–10. http://dx.doi.org/10.1016/s1639-870x(14)68026-0.
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Passali, D., and F. Piragine. "A Comparison of Azelastine Nasal Spray and Cetirizine Tablets in the Treatment of Allergic Rhinitis." Journal of International Medical Research 22, no. 1 (January 1994): 17–23. http://dx.doi.org/10.1177/030006059402200102.
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A total of 40 patients with perennial allergic rhinitis were treated with either azelastine nasal spray 0.14 mg/nostril twice daily (0.56 mg/day) or cetirizine tablets 10 mg once daily. Treatment was for a period of eight weeks. The rhinitis symptoms were evaluated according to a four-point scale (0 = absent, 3 = severe). The Total Rhinitis Symptom Score (TRSS) was derived from the sum of the individual symptom scores. Symptoms were assessed at baseline prior to treatment and at weeks 2, 4 and 8. Compared to baseline, TRSS for both the azelastine and cetirizine groups were less at each assessment during treatment, a slight nonsignificant advantage was seen in the azelastine group. At the end of the study, physicians rated global efficacy as being ‘good’ or ‘excellent’ in 73.7% of azelastine patients and 55.5% of cetirizine patients. Both treatments were well tolerated and no serious adverse events were reported, however, two cetirizine patients withdrew from the study because of somnolence. In conclusion, azelastine has been shown to be at least as effective as cetirizine in the relief of the symptoms of perennial allergic rhinitis. Un campione clinico di 20 + 20 pazienti con rinite allergica è stato trattato con Azelastina spray nasale alla dose di 2 puff da 0.14 mg/narice/die (0.56 mg/die) o con 1 compressa/die di Cetirizina da 10 mg. La durata del trattamento è stata di 8 settimane. I sintomi di rinite sono stati valutati in base ad una scala a 4 punti (in cui 0 = assente o scomparso, 3 = sintomo grave). Il Punteggio Totale dei Sintomi di Rinite (PTSR) è stato ottenuto addizionando i punteggi dei singoli sintomi. I sintomi sono stati rilevati prima dei trattamenti (valore basale) e successivamente ad intervalli di 2, 4 e 8 settimane. Ad ogni rilevamento nel corso del trattamento si è riscontrata una diminuzione del PTSR rispetto al valore basale, in entrambi i gruppi di trattamento. Nel gruppo Azelastina si è manifestata una maggiore diminuzione del punteggio, non statisticamente significativa. Alla conclusione dello studio i ricercatori hanno definita “eccellente” o “buona” l'efficacia nel 73.7% del casi trattati con Azelastina Spray Nasale e nel 55.5% di quelli trattati con Cetirizina. Entrambi i trattamenti sono stati ben tollerati e non si sono rilevati effetti collaterali. In conclusione, Azelastina Spray Nasale, ha dimostrato efficacia comparabile a quella di Cetirizina compresse nell'alleviare i sintomi della rinite allergica.
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Gambardella, R. "A Comparison of the Efficacy of Azelastine Nasal Spray and Loratidine Tablets in the Treatment of Seasonal Allergic Rhinitis." Journal of International Medical Research 21, no. 5 (September 1993): 268–75. http://dx.doi.org/10.1177/030006059302100505.
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A total of 30 patients suffering from seasonal allergic rhinitis were treated in a 6-week randomized, double-blind, double-dummy parallel-group study, comparing azelastine nasal spray (0.14 mg/nostril administered twice daily) and loratidine tablets (10 mg once daily). Symptoms evaluated were sneezing, nose and/or eye itching, lacrimation, rhinorrhoea, photophobia, nasal occlusion, throat irritation, smell loss, nasal mucosa swelling, conjunctivitis, and pharyngeal mucosa reddening. Each symptom was assessed according to severity and given a score on a fourpoint rating scale. Compared with baseline, total symptom scores for both the azelastine and loratidine treatment groups were reduced at each of the assessments during treatment. No significant differences were observed between the two treatment groups. The investigator concluded that azelastine, formulated as a nasal spray, is as effective as loratidine tablets in the relief of the symptoms of seasonal rhinitis and that it has a rapid onset of action. Un gruppo di 30 pazienti affetti da rinite allergica stagionale è stato trattato, in uno studio radomizzato, tra gruppi paralleli, doppio cieco, double dummy della durata di 6 settimane con azelastina spray nasale (0.14 mg/narice 2 volte al giorno) e loratina compresse (10 mg/die). I sintomi controllati sono stati i seguenti: starnuti, prurito nasale e/o oculare, lacrimazione, rinorrea, fotofobia, occlusione nasale, irritazione faringea, perdita dell'olfatto, edema della mucosa nasale, congiuntivite ed arrossamento della mucosa faringea. I sintomi sono stati valutati in base alia loro gravità assegnando un punteggio variabile da 1 a 4. In entrambi i gruppi di trattamento il punteggio totale della sintomatologia è risultato inferiore a quello basale ad ogni controllo nel corso dei trattamenti. Non sono state rilevate differenze significative tra i due trattamenti che si sono dimostrati entrambi efficaci. I ricercatori hanno concluso che azelastina spray nasale ha la stessa efficacia di loratidina compresse nell'alleviare i sintomi della rinite allergica stagionale e possiede una notevole rapidità di azione ed una notevole maneggevolezza clinica.
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ÖZGEN ALPAYDIN, Aylin, Mine BORA, Kıvanç GÜNHAN, Aydın İŞİSAĞ, Onur ÇELİK, Pınar ÇELİK, Fatma TANELİ, and Arzu YORGANCIOĞLU. "Lower Airway Inflammation in Nonasthmatic Allergic Rhinitis Patients." Turkiye Klinikleri Journal of Medical Sciences 31, no. 4 (2011): 837–44. http://dx.doi.org/10.5336/medsci.2010-19523.
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Aryati, Aryati, Dwi Retno Pawarti, Izzuki Muhashonah, and Janti Tri Habsari. "KAITAN IgE SPESIFIK METODE IMUNOBLOT TERHADAP ELISA PADA RINITIS ALERGI." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 21, no. 3 (September 13, 2016): 298. http://dx.doi.org/10.24293/ijcpml.v21i3.744.
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Allergic rhinitis is an allergic disease that is most often found beside bronchial asthma and eczema with the prevalence of is about 33.3%, 9.8% and 11.2% respectively. The main examinations of allergic rhinitis are Skin Prick Test (SPT) and specific IgE, becausethe sensitivity and specificity of specific IgE examination depend on the examination method. To know the diagnostic value of specific IgE immunoblot examination by determination and were compared with ELISA in patients with allergic rhinitis. The cross-sectional design of the study is con-ducted on patients at the Outpatient Clinic Department of ENT-Head and Neck from May until October 2014. Patients were grouped as diagnosis of allergic rhinitis and non-allergic non-infectious rhinitis based on clinical signs and symptoms, physical examina-tion, positive in SPT examination with or without an increase in total serum IgE and/or blood eosinophils. Specific IgE immunoblot was conducted by using Foresight®, Acon Laboratories and the ELISA method using Allercoat™. The sensitivity and specificity of inhalant allergen -specific IgE immunoblot Foresight® method was 73.9% and 42.9%, respectively. The sensitivity and specificity of inhalant allergen -specific IgE ELISA method was 67.4% and 57.1%, respectively. The results of these two methods have a correlation coefficient 0.531 with p=0.000. The sensitivity and specificity of ingestan allergen specific IgE immunoblot Foresight® method was 41.3% and 85.7%, respectively. The sensitivity and specificity of ingestan allergen specific IgE ELISA method was 17.4 and 78.6%, res-pectively. Results of these two methods have a correlation coefficient 0.375 with p=0.003. Based on this study of specific IgE immunoblot and ELISA methods, both have diagnostic sensitivity and specificity, which are almost the same. The sensitivity of immunoblot method inhalant allergens are superior to ELISA. The Immunoblot method ingestan allergen specificity is superior to ELISA.
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Muhashonah, Izzuki, Aryati Aryati, Dwi Reno Pawarti, M. Robi’ul Fuadi, and Janti Trihabsari. "SPECIFIC IGE IMMUNOBLOT METHOD IN ALLERGIC RHINITIS (IgE Spesifik Menurut Metode Imunoblot di Rinitis Alergi)." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 22, no. 3 (April 15, 2018): 246. http://dx.doi.org/10.24293/ijcpml.v22i3.1240.
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Rinitis alergi merupakan penyakit bukan akibat non-infeksi yang ditemukan antara 10−30% penduduk dewasa dunia dan dapatmenyebabkan penurunan mutu kehidupan seseorang. Rinitis alergi merupakan manifestasi alergi tipe 1 atau tipe cepat yang dimediasioleh IgE. Pemeriksaan utama rinitis alergi adalah Skin Prick Test (SPT) dan IgE spesifik. Pemeriksaan IgE spesifik mempunyai kepekaandan kekhasan yang menyerupai SPT, tidak memerlukan tenaga terlatih dan menyebabkan anafilaktik. Penelitian ini untuk mengetahuiadakah kesesuaian nilai diagnostik IgE spesifik menurut metode imunoblot dengan SPT di pasien rinitis alergi dengan mengujinya.Rancangan penelitian adalah potong lintang yang dilakukan terhadap pasien yang datang di Unit Rawat Jalan THT-KL RSUDDr. Soetomo pada bulan Mei sampai dengan Oktober 2014. Pasien dikelompokkan berdasarkan diagnosis rinitis alergi dan yang nonalergidan non-infeksi serta ditetapkan secara klinis, ada riwayat alergi, pemeriksaan fisik, serta tingkat jumlah keseluruhan IgE serumdan atau eosinofil darah. Pemeriksaan SPT dilakukan dengan memakai ekstrak alergen dari Stallergens dan IgE spesifik menurut metodeimunoblot memakai Foresight®. Dalam kajian ini didapatkan empat puluh tiga pasien didiagnosis rinitis akibat alergi. Hasil IgE spesifikmenurut metode imunoblot positif terdapat di 36 (84%) pasien dengan pola alergen terbanyak D1/D2 29 (67%). Kepekaan dan kekhasandiagnostik IgE spesifik menurut metode imunoblot berturut-turut adalah 72,34% dan 46,15%. Kesesuaian nilai diagnostik IgE spesifikmenurut metode imunoblot dengan SPT mempunyai koefisien kappa 0,158. Didasari telitian ini tidak didapatkan kesesuaian antaraIgE spesifik menurut metode imunoblot dengan SPT. Di ketahui pula bahwa IgE spesifik menurut metode imunoblot dapat digunakanbersama-sama dengan SPT dalam mendiagnosis rinitis akibat alergi.
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De Corso, E., G. Bastanza, V. Di Donfrancesco, M. L. Guidi, G. Morelli Sbarra, G. Passali, A. Poscia, C. de Waure, G. Paludetti, and J. Galli. "Riduzione volumetrica dei turbinati inferiori con radiofrequenze: risultati clinici a lungo termine." Acta Otorhinolaryngologica Italica 36, no. 3 (May 2016): 199–205. http://dx.doi.org/10.14639/0392-100x-964.
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Lo scopo del nostro studio è stato quello di valutare i risultati a lungo termine della procedura di riduzione volumetrica dei turbinati inferiori mediante radiofrequenze (RVTR). Abbiamo eseguito una valutazione prospettica longitudinale a lungo termine di 305 pazienti affetti da rinite (114 allergici e 191 non allergici) refrattari alla terapia medica e sottoposti a intervento di RVTR (gennaio 2004 - dicembre 2010). I pazienti sono stati seguiti per un Follow-up medio di 39,70±19,41 mesi (minimo-24, massimo-60 mesi) e sono stati valutati mediante la somministrazione del questionario NOSE-scale prima e dopo l’intervento a distanza di un mese e successivamente ogni anno per 5 anni. I pazienti sono stati considerati affetti da recidiva durante il periodo di follow-up in caso di ricomparsa dei sintomi con un aumento del punteggio totale del NOSE scale di almeno il 75% e necessità di riassumere trattamenti medici. La ricorrenza è stata valutata mediante analisi di sopravvivenza con il metodo di Kaplan-Meyer. Complessivamente abbiamo documentato una buona soddisfazione dei pazienti per quanto riguarda la procedura, con un elevato controllo del dolore e poche complicanze. Nel post-operatorio abbiamo avuto un significativo miglioramento di ostruzione nasale e respirazione orale vicariante (p < 0,05). Dopo 36 mesi abbiamo osservato un peggioramento dei sintomi, in particolare, dopo 36 mesi con un progressivo crescente tasso di recidive significativamente più elevato nei pazienti allergici rispetto a quelli non-allergici (p < 0,05). Abbiamo anche osservato una leggera diminuizione della soddisfazione generale dei pazienti. Il nostro studio conferma la buona tollerabilità da parte dei pazienti della procedura di decongestione dei turbinati inferiori con radiofrequenze con un basso rischio di complicanze. I nostri dati confermano inoltre una buona efficacia a lungo termine nella maggior parte dei pazienti per almeno 36 mesi dopo l’intervento con una probabilità di rimanere liberi da recidiva in questo periodo sempre superiore a 0,8. Nei mesi successivi si assiste a una progressiva riduzione del beneficio clinico in particolare nei pazienti allergici, con una differenza statisticamente significativa rispetto ai pazienti non allergici (p < 0,05).
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Kairavini, Ardyatri, Trisna Ariani, Sukdriani Utami, and Nurman Hikmallah. "HUBUNGAN TUNGAU DEBU RUMAH TERHADAP ANGKA KEJADIAN RINITIS ALERGI YANG BEROBAT DI POLI THT RSUD BANGLI TAHUN 2019." JURNAL KEDOKTERAN 5, no. 2 (June 2, 2020): 57. http://dx.doi.org/10.36679/kedokteran.v5i2.237.
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Background: Rhinitis Allergic is an inflammatory process in the nasal mucosa caused by type I hypersensitivity reactions that are triggered by certain allergens. The prevalence of rhinitis allergic in Indonesia is estimated to range between 10- 20% and is constantly increasing. The average Onset age of Rhinitis Allergic is 8- 11 years old and 80% of rhinitis allergic develops at the age of 20 years old. Usually rhinitis allergic occurs at a young age. Rhinitis Allergic can be triggered by several types of aeroallergens, one of which is house dust mites. Lopo C research mentioned that most allergens cause allergic rhinitis are house dust mites that is equal to (75.6%). Objective: To determine the correlation of house dust mites to the incidence of rhinitis allergic being treated at the ENT Polyclinic in Bangli Regional Hospital in 2019. Method: This study was an observational study with a cross sectional design. Samples were taken based on primary and secondary data using non-probability sampling techniques by purposive sampling. The samples used in this study were 143 samples of rhinitis patients. Data analysis using Chi Square. Results: The results obtained from the Chi Square test did not have a significant correlation of house dust mites and the number of incidence of allergic rhinitis is p-value 0.060 (p> 0.05). Conclusion: There is no significant correlation of household dust mites and the incidence of rhinitis allergic in the ent polyclinic of Bangli hospital in 2019.
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Aryati, Aryati, Dwi Retno Pawarti, Izzuki Muhashonah, and Janti Tri Habsari. "KAITAN IgE SPESIFIK METODE IMUNOBLOT TERHADAP ELISA PADA RINITIS ALERGI (Association Between Specific IgE Immunoblot Method with ELISA on Allergic Rhinitis)." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 21, no. 3 (April 18, 2018): 298. http://dx.doi.org/10.24293/ijcpml.v21i3.1284.
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Allergic rhinitis is an allergic disease that is most often found beside bronchial asthma and eczema with the prevalence of is about33.3%, 9.8% and 11.2% respectively. The main examinations of allergic rhinitis are Skin Prick Test (SPT) and specific IgE, becausethe sensitivity and specificity of specific IgE examination depend on the examination method. To know the diagnostic value of specificIgE immunoblot examination by determination and were compared with ELISA in patients with allergic rhinitis. The cross-sectionaldesign of the study is con-ducted on patients at the Outpatient Clinic Department of ENT-Head and Neck from May until October 2014.Patients were grouped as diagnosis of allergic rhinitis and non-allergic non-infectious rhinitis based on clinical signs and symptoms,physical examina-tion, positive in SPT examination with or without an increase in total serum IgE and/or blood eosinophils. SpecificIgE immunoblot was conducted by using Foresight®, Acon Laboratories and the ELISA method using Allercoat™. The sensitivity andspecificity of inhalant allergen -specific IgE immunoblot Foresight® method was 73.9% and 42.9%, respectively. The sensitivity andspecificity of inhalant allergen -specific IgE ELISA method was 67.4% and 57.1%, respectively. The results of these two methods havea correlation coefficient 0.531 with p=0.000. The sensitivity and specificity of ingestan allergen specific IgE immunoblot Foresight®method was 41.3% and 85.7%, respectively. The sensitivity and specificity of ingestan allergen specific IgE ELISA method was 17.4 and78.6%, res-pectively. Results of these two methods have a correlation coefficient 0.375 with p=0.003. Based on this study of specificIgE immunoblot and ELISA methods, both have diagnostic sensitivity and specificity, which are almost the same. The sensitivity ofimmunoblot method inhalant allergens are superior to ELISA. The Immunoblot method ingestan allergen specificity is superior toELISA.
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Habsari, Janti Tri, Aryati Aryati, and Dwi Reno Pawarti. "PERBANDINGAN NILAI DIAGNOSTIK IGE SPESIFIK TUNGAU DEBU RUMAH, METODE ELISA DAN IMUNOBLOT PADA RINITIS ALERGI." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 22, no. 2 (March 27, 2018): 119. http://dx.doi.org/10.24293/ijcpml.v22i2.1113.
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The detection of allergen types is very helpful in allergic rhinitis (AR) management. Some methods had been performed to examinethe specific IgE due to HDM such as ELISA and immunoblot methods. The aim of this research is to know the difference of specificIgE diagnostic value due to HDM between ELISA and immunoblot in allergic rhinitis method which is expected to be used as in vitroalternative method which is safe, fast, effective, with a high sensitivity and specificity by provement. The samples were allergic rhinitisand non-allergic rhinitis patients at ENT of Head and Neck Out patients Clinic of Dr. Soetomo Hospital Surabaya. The sera was examinedfor specific IgE due to HDM by ELISA and immunoblot methods and then analyzed for its diagnostic value using the 2 x 2 table with a95% confidence interval. The comparation between both methods were analyzed with Wilcoxon test. The diagnostic value of the specificHDM IgE with immunoblot method showed sensitivity of 90% and 80% specificity, positive predictive value 90% and the negative 80%and diagnostic efficiency 86.67%. The positive likelihood ratio 4.5 and the negative one 0.125. The diagnostic value of the specific IgEHDM/D.p with ELISA showed a sensitivity of 75% and specificity 75%, the positive predictive value 85.71% and the negative one 0%and diagnostic efficiency 75%. The positive likelihood ratio was 3 and the negative one 0.33. The diagnostic value of the specific IgEHDM with immunoblot showed a sensitivity of 90% and specificity 80%, the positive predictive value 90% and the negative one 80%and the diagnostic efficiency 86.67%. The positive likelihood ratio was 4.5 and the negative one 0.125. The difference of diagnostic valuein both methods revealed that the p value was 0.013. It can be concluded in this study that there was a significant difference of specificIgE due to HDM between ELISA and immunoblot methods in allergic rhinitis.
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Reksodiputro, Lupita, Thalia Mufida, Niken Poerbonegoro, and Mirta Hediyati Reksodiputro. "Association Between Active or Passive Smoking and Allergic Rhinitis: an Evidence-Based Case Report." eJournal Kedokteran Indonesia 9, no. 1 (May 5, 2021): 56. http://dx.doi.org/10.23886/ejki.9.22.56.
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This evidence-based case report (EBCR) aims to investigate the association between active or passive smoking with allergic rhinitis by summarizing existing studies on the topic. A literature search was done on major databases with keywords related to this study’s research question. The literature was appraised using CEBM University of Oxford for etiology study and systematic review sheets. The search obtained two articles for critical appraisal, includes a meta-analysis and a cohort study. The studies were appraised as valid, important, and applicable to the writer’s setting. Saulyte et al’ s2 article described RR active smoking with allergic rhinitis of 1.02 (95%CI 0.92-1.15), with no significant association. They resolved the heterogeneity by making subgroups. The cross-sectional subgroup with RR 1.09 (95%CI 1.06-1.12) is statistically significant. There was a significant association in passive smoking and obtained RR 1.10 (95%CI 1.06-1.15). In the study by Mlinaric et al4 the RR of active and passive smoking compared to non-smoker are 1.82 and 2.00; both show statistical significance. Both active and passive smoking is associated with a high risk of allergic rhinitis in adults and children. Keywords active smoking, passive smoking, allergic rhinitis. Hubungan Perokok Aktif dan Pasif dengan Rhinitis Alergi: Laporan Kasus Berbasis Bukti Abstrak Pada laporan kasus berbasis bukti ini bertujuan untuk menginvestigasi hubungan antara perokok aktif dan perokok pasif pada pasien dengan rinitis alergi. Dilakukan pencarian literatur menggunakan kata kunci yang berhubungan dengan kasus pada beberapa search engine, kemudian dilakukan penilaian kelayakan dengan lembar appraisal dari CEBM University of Oxford for etiology study and systematic review sheet. Dari pencarian didapatkan dua artikel yang mepresentasikan kasus tersebut, yaitu studi meta analisis dan studi cohort. Studi meta analisis oleh Saulyte et al2 menyatakan RR pada perokok aktif dengan rinitis alergi adalah 1,02 (95%CI 0,92-1,15). Pada subgrup potong lintang didapatkan perbedaan bermakna dengan RR 1,09 (95%CI 1,06-1,12). Pada studi cohort oleh Minaric et al didapatkan RR pada perokok aktif 1,82 dan pada perokok pasif 2,00, keduanya menunjukan angka yang signifikan. Pada perokok aktif dan pasif berhubungan dengan risiko tinggi pada rinitis alergi di pasien dewasa dan anak-anak. Kata kunci: perokok aktif, perokok pasif, rhinitis alergi.
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Susanti, Eva, Dwi Reno Pawarti, and Soeprijadi Soeprijadi. "Hubungan kadar RANTES sekret hidung dengan skor gejala total penderita rinitis alergi." Oto Rhino Laryngologica Indonesiana 46, no. 2 (December 30, 2016): 110. http://dx.doi.org/10.32637/orli.v46i2.158.
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Latar belakang: Rinitis alergi (RA) adalah penyakit inflamasi mukosa hidung yang diperantarai oleh imunoglobulin E (IgE) akibat pajanan alergen. Salah satu tanda penting proses alergi adalah infiltrasi sel-sel inflamasi, utamanya eosinofil ke jaringan, dan melepaskan berbagai protein dasar yang dapat merusak epitel mukosa hidung. Proses tersebut sangat dipengaruhi oleh peran regulated upon activation normal T cell expressed and secreted (RANTES). Pengukuran beratnya gejala RA dilakukan secara subyektif dengan menghitung skor gejala total (SGT), serta obyektif melalui kadar RANTES sekret hidung. Tujuan: Penelitian ini bertujuan untuk membuktikan hubungan antara kadar RANTES sekret hidung dengan SGT pada penderita RA. Metode: Penelitian dilaksanakan pada bulan Juli-Desember 2015 di Unit Rawat Jalan Telinga Hidung Tenggorok - Bedah Kepala Leher Divisi Alergi Imunologi dan Instalasi Patologi Klinik Rumah Sakit Dr. Soetomo Surabaya. Jenis penelitian ini adalah analitik observasional dengan menggunakan rancang bangun cross sectional. Pengambilan sampel dilakukan secara consecutive sampling dan didapatkan sampel sebanyak 49. Kadar RANTES sekret hidung diukur dengan metode ELISA. Skor gejala total diperoleh dari penjumlahan keseluruhan gejala, baik gejala hidung maupun gejala di luar hidung. Uji korelasi yang digunakan adalah uji Pearson. Hasil: Rerata dan standar deviasi (SD) kadar RANTES pada penelitian ini adalah 17,68 pg/ml (8,24) dan rerata (SD) SGT adalah 11,37 (3,15 pg/ml). Diagram scatter plot menunjukkan bahwa data terdistribusi normal. Hasil tes korelasi Pearson kadar RANTES sekret hidung dan SGT pada penderita RA didapatkan koefisien korelasi (r) sebesar 0,426 dan p=0,002. Kesimpulan: Terdapat hubungan positif dengan korelasi sedang antara kadar RANTES sekret hidung dan SGT pada penderita RA. Kata kunci: Rinitis alergi, RANTES, skor gejala total ABSTRACT Background: Allergic rhinitis (AR) is an inflammatory disease of nasal mucosa which is mediated by Imunoglobulin E (IgE) as a response to an allergic exposure. One important sign of an allergic process is the infiltration of inflammatory cells particullary eosinophils into the mucosal tissue, which release a variety of basic proteins that may damage the nasal mucosal epithelium. The process of migration and infiltration of inflammatory cells was strongly influenced by the role of regulated upon activation normal T cell expressed and secreted (RANTES). Evaluation of AR can be done by calculating total symptoms score (TSS) and RANTES levels in nasal secretion. Purpose: This study aimed to prove the relation between the levels of RANTES nasal secretion and TSS in AR patients. Methods: Research was conducted at Allergy–Immunology Division of Otorhinolaryngology–Head and Neck Surgery (ORL-HNS) Outpatient Department of Dr. Soetomo Hospital, Surabaya in July to December 2015. Samples were taken by consecutive sampling and obtained 49 samples. Levels of RANTES in nasal secretion were measured by ELISA method. Total symptoms scores were obtained by accumulating all the symptoms, either nasal symptoms or non nasal symptoms. This study used correlation of Pearson as the statistical analytic test. Results: Mean (SD) RANTES of this study was 17.68 pg/ml (8.24) and mean (SD) of TSS was 11.37 pg/ml (3.15). Scatter plot diagram showed that data were distributed normally. The results of Pearson test showed that there were significant correlation between the levels of RANTES nasal secretion and TSS in AR patients with correlation coefficient (r)=0.426 and p=0.002. Conclusion: There was a positive relationship with moderate correlation between the levels of RANTES nasal secretion and TSS in allergic rhinitis patients.Keywords: Allergic rhinitis, RANTES, total symptom scores
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Wardani, Retno Sulistyo, Azmi Mir’ah Zakiah, Yoan Levia Magdi, Dolly Irfandy, Anna Mailasari Kusuma Dewi, Budi Sutikno, Sarwastuti Hendradewi, Sinta Sari Ratunanda, and Delfitri Munir. "Penggunaan terkini oksimetazolin pada praktik klinik sehari-hari dan rekomendasi Kelompok Studi Rinologi Indonesia." Oto Rhino Laryngologica Indonesiana 46, no. 2 (December 30, 2016): 171. http://dx.doi.org/10.32637/orli.v46i2.165.
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Latar belakang: Oksimetazolin adalah bahan aktif dekongestan topikal yang digunakan untuk rinitis alergi maupun inflamasi mukosa hidung lainnya. Cara pemakaian oksimetazolin yang baik dan benar akan memengaruhi keberhasilan pengobatan. Efek samping rinitis medikamentosa merupakan komplikasi yang sering terjadi dan sebaiknya dapat dicegah. Tujuan: Penulisan tinjauan pustaka ini untuk memberikan pemahaman terkini tentang berbagai indikasi oksimetazolin pada praktik klinik Telinga Hidung Tenggorok sehari-hari, cara pemakaian yang tepat, efek samping dan komplikasi yang terjadi berdasarkan studi kepustakaan yang dipublikasikan di PubMed, Google Scholar, dan Scopus dalam 10 tahun terakhir (2007–2016) oleh tim adhoc anggota Kelompok Studi (KODI) Rinologi Indonesia. Tinjauan pustaka: Oksimetazolin memiliki indikasi yang diperluas jika digunakan bersama dengan bahan aktif lain. Oksimetazolin semprot hidung 0,05% yang digunakan bersama dengan steroid intranasal dilaporkan memberikan manfaat pada penatalaksanaan rinitis alergi, rinitis kronis, dan polip hidung. Oksimetazolin digunakan juga dalam bedah sinus endoskopik untuk mendapatkan visualisasi lapang operasi yang baik karena efek hemostatik vasokonstriktor intranasal. Keuntungan yang dilaporkan juga diiringi dengan kemungkinan efek samping dan komplikasi yang sudah dikenal sampai yang membahayakan hingga kematian akibat koarktasio aorta, infark miokard elevasi non-ST, dan krisis hipertensi. Kesimpulan: Rekomendasi yang dibuat oleh KODI Rinologi berdasarkan analisis secara sistematik dengan telaah kritis, diharapkan dapat meningkatkan pengetahuan dan pemahaman tentang penggunaan oksimetazolin yang bermanfaat dan dapat mencegah efek samping yang berbahaya.Kata kunci: Oksimetazolin, dekongestan intranasal, indikasi, efek samping, komplikasiABSTRACT Background: Oxymetazoline is an active ingredient of topical decongestant in treating allergic rhinitis and other nasal mucosal inflammation. A good and proper usage of oxymetazoline will influence a beneficial outcome. Rhinitis medicamentosa is a common complication that should be avoided. Purpose: Content of the literature review is the indications of oxymetazoline usage in daily ENT clinical practice; the proper usage, side effects and complications are appraised from Pubmed, Scopus and Google Scholar publications within the last 10 years (2011 – 2015). The work was performed by adhoc team consisted of member of Rhinology Study Group Indonesia. Literature Review: Oxymetazoline broader indications obtained when applied together with other active ingredients. Oxymetazoline 0.05% nasal spray with topical intranasal steroid was reported as having efficacy in management of allergic rhinitis, chronic rhinitis and nasal polyps. Oxymetazoline is used as topical vasoconstrictor during endoscopic sinus surgery to get clear endoscopic visualization due to its hemostatic effect. Combination of oxymetazoline with topical intranasal steroid, was reported to be beneficial in the management of allergic rhinitis, chronic rhinitis and nasal polyps. Oxymetazoline is also used as topical vasoconstrictor during endoscopic sinus surgery to get clear endoscopic visualization due to its hemostatic effect. The good result of oxymetazoline was reported along with its side effects, which could be fatal, such as coarctation of the aorta, non-ST elevation myocardial infarction, and critical hypertension. Conclusion: Recommendation from Rhinology Study Group Indonesia based on systematic analysis with critical appraisal that has been made, may widen the knowledge and understanding of oxymetazoline usage and indications, and also avoiding the dangerous side effects and complications.Keywords: Oxymetazoline, topical intranasal decongestant, indication, side effect, complication
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Bondarenko, Tatyana, Viktor Litus, Alexey Kuznetsov, Larisa Kuznetsova, and Oleg Nazar. "STAN IMMUNITETU AND CORRECT REMEDIES IN BORIES ON SEASONAL ALERGIC RINIT ON ONLY DESTRUCTED INTESTINAL MICROBIOCENOSIS THAT KARCHATOUS STATUS." Immunology and Allergy: Science and Practice, no. 4 (December 23, 2019): 26–34. http://dx.doi.org/10.37321/immunology.2019.04-04.
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Introduction. Nutrition is one of the most significant environmental factors that affects the functional state of all organs and systems, determines the state of adaptive capabilities of the body, promotes health, or vice versa, causes the development of diseases, contributes to their chronicity and progress. The functional state of organs and systems by a patient with seasonal allergic rhinitis (ATS) is determined by the reserves of energy, plastic and regulatory support that cells receive with food. Inadequate nutrition is also one of the causes of secondary immunodeficiency, which has a negative effect on the course of ATS.
Materials and methods. We studied 75 patients with ATS with mild and moderate disorders of the pathological process and taking into account disturbances in intercellular cooperation, an increase in IL-4, specific IgE and TNF-α against the background of a nutritional disorder occurring with mild immunological indicators of systemic immunity.
Research results. Three groups of patients were distinguished: 1 group of 25 patients with a lack of body weight; Group 2 – 25 patients whose body weight was within normal limits; Group 3 – 25 overweight patients and Group 4 (control) comparisons (healthy people) – 25 people.
Discussion of research. The data obtained indicate the effectiveness of the developed therapy, which includes dietary correction and a comprehensive differentiated approach in the appointment of pre- and probiotics. The effectiveness of treatment is indicated by the positive dynamics of the clinical manifestations of intestinal dysbiosis.
Conclusions. In addition to positive changes in intestinal symptoms, in patients with ATS, there was a positive dynamics in the gastrointestinal tract, as well as normalization of specific and non-specific indicators of immunity. The effectiveness of the specific treatment of patients with ATS against intestinal dysbiosis is increased by 85%.
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Hutagaol, Ayu Betty, and Indri Adriztina. "The differences in the quality of life of allergic rhinitis and non-symptomatic individuals." Oto Rhino Laryngologica Indonesiana 51, no. 2 (January 1, 2022). http://dx.doi.org/10.32637/orli.v51i2.428.
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ABSTRACTBackground: Allergic rhinitis is a chronic inflammatory disorder of the nose that occurs as an IgE-mediated reaction. Classical symptoms of allergic rhinitis are sneezing, nasal congestion, nasal itching and rhinorrhea. The effects of allergic rhinitis can have an impact on daily activities that affect the quality of life of sufferers. Purpose: To determine the differences between the quality of life of allergic rhinitis sufferers and non-symptomatic subjects in the Faculty of Medicine, University of North Sumatra batch 2017. Methods: This was an observational study with a cross-sectional design. The research sample was obtained by total sampling technique and used two questionnaires, Score for Allergic Rhinitis (SFAR) to assess allergic rhinitis, and 36-Item Short Form Health Survey (SF 36) to assess the quality of life of the research subjects, which were students of the Faculty of Medicine, University of North Sumatra, of the year 2017. Result: Among 213 students from the Faculty of Medicine, University of Sumatera Utara of the year 2017, there were 112 allergic rhinitis sufferers and 101 non-symptomatic students. The median quality of life score for allergic rhinitis sufferers was 74, while the median score of quality of life for non-symptomatic students was 78. Using Man Whitney test, the result obtained p value <0.05 (p = 0.044). Conclusion: There was a significant difference between the quality of life of students with allergic rhinitis and non-symptomatic individuals.Keywords: allergic rhinitis, quality of life, SFAR, SF-36ABSTRAKLatar belakang: Rinitis alergi merupakan inflamasi yang terjadi pada hidung akibat adanya reaksi alergi yang diperantarai oleh IgE. Gejala rinitis alergi berupa bersin-bersin, hidung tersumbat, serta hidung gatal dan rinore. Gejala rinitis alergi dapat berdampak pada aktivitas sehari-hari sehingga mempengaruhi kualitas hidup penderitanya. Tujuan: Mengetahui perbedaan kualitas hidup penderita dan bukan penderita rinitis alergi pada mahasiswa Fakultas Kedokteran Universitas Sumatera Utara, angkatan 2017. Metode: Penelitian ini merupakan jenis penelitian analitik observasional dengan rancangan cross-sectional. Sampel penelitian ditentukan dengan teknik total sampling dan menggunakan dua buah kuesioner yaitu Score for Allergic Rhinitis (SFAR) untuk menilai rinitis alergi dan 36-Item Short Form Health Survey (SF-36) untuk menilai kualitas hidup. Subjek penelitian adalah mahasiswa Fakultas Kedokteran Universitas Sumatera Utara angkatan 2017. Hasil: Dari 213 mahasiswa Fakultas Kedokteran Universitas Sumatera Utara angkatan 2017, didapati 112 penderita rinitis alergi dan 101 bukan penderita rinitis alergi. Skor median kualitas hidup penderita rinitis alergi adalah 74 sedangkan skor median kualitas hidup mahasiswa bukan penderita rinitis alergi adalah 78. Dengan uji Man Whitney diperoleh hasil p value <0,05 (p=0,044). Kesimpulan: Penelitian ini menunjukkan adanya perbedaan signifikan antara kualitas hidup penderita rinitis alergi dan bukan penderita rinitis alergi.Kata kunci: rinitis alergi, kualitas hidup, SFAR, SF 36
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Halvani, Gholam Hossein, Elham Halvani, Fatemeh Kargar, and Mohammad Amrollahi. "Evaluation and comparison the incidence of respiratory diseases in poultry and livestock breeders in yazd." Occupational Medicine, December 26, 2018. http://dx.doi.org/10.18502/tkj.v10i3.229.
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Background and aim:
Farmers that have occupational exposed to the organic dust, bacteria, endotoxin, mites, and fungi, as well as the hazardous gases such as ammonia, sulfides, hydrogen and nitrogen oxides, may be affected by allergic asthma, non-allergic rhinitis, and organic dust toxic syndrome. This study aimed to determine the prevalence of respiratory symptoms and spirometry parameters between the two groups of livestock breeders and ranchers farmers. Material & Method: The cross-sectional descriptive-analytic study was performed in Yazd on a 300 agricultural men. The questionnaire includes demographic information including age, work experience, cigarette smoking, the type of agricultural activity and respiratory symptoms among farmers. Pulmonary function tests of all farmers were performed in a sitting position after the animals were fed. Moreover, indicators of FVC, FEV1, FEV1 / FVC, PEF25-75 were measured. T-test test data for the logistic regression analysis was used. Findings: The results showed that respiratory capacity in the poultry is less than livestock breeder's. Cough, sputum prevalence of respiratory symptoms such as shortness of breath, wheezing and rhinitis in poultry was significantly higher than those in other groups were. The highest prevalence was related to nasal allergies [(OR=5.04 (2.7-9.4)]. Respiratory symptoms increased with age exception of nasal allergies. Comparison the age group showed 3.3 increased times Cough [(OR=3.3 (1.74-6.3)] and 2.5 sputum [(OR=2.5 (1.05-6.21)] in the age group 75 to 55 years age group 34-20 years, respectively. the prevalence of respiratory symptoms was higher in smokers than non-smokers, so that the incidence of cough, sputum, shortness of breath, wheezing and rinite allergic the This group, , 64/1, 5/1, 46/1, 7/1 and 75/1 times more than non-smokers respectively but this association was not statistically significant. Conclusion: Due to the high prevalence of respiratory symptoms in farmers, agricultural mechanization promotion of health knowledge of farmers by implementing appropriate training programs is necessary.
Keywords: Respiratory disorders, Farmers, Poultry, livestock breeders, Spirometry
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"Nasal ipratropium can dry watery rhinorrhoea." Drug and Therapeutics Bulletin 28, no. 14 (July 9, 1990): 54–55. http://dx.doi.org/10.1136/dtb.28.14.54.
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Perennial rhinitis causes nasal obstruction, sneezing and watery rhinorrhoea. Often it is due to an allergy, e.g. house-dust mite, and may then respond to treatment with a topical corticosteroid or sodium cromoglycate, or an oral antihistamine. Perennial non-allergic ‘vasomotor’ rhinitis occurs throughout the year and is usually resistant to such treatment; patients whose main symptom is a blocked nose may be helped by surgery to the turbinates, but for those with watery rhinorrhoea a clean handkerchief often provides the only solace. Ipratropium nasal aerosol spray (Rinatec - Boehringer Ingelheim) is intended for them. Is it helpful?