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Relevant bibliographies by topics / “Ring-opened” derivatives

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Academic literature on the topic '“Ring-opened” derivatives'

Author: Grafiati

Published: 10 September 2021

Last updated: 12 February 2022

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Journal articles on the topic "“Ring-opened” derivatives"

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Andreani, Aldo, Alberto Leoni, Alessandra Locatelli, Rita Morigi, Mirella Rambaldi, Jean-Claude Gehret, Serena Traniello, Alessio Cariani, and Susanna Spisani. "Ring-Opened Analogs of Indomethacin Affecting Human Neutrophil Functions." Collection of Czechoslovak Chemical Communications 64, no. 2 (1999): 299–312. http://dx.doi.org/10.1135/cccc19990299.

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A series of ring-opened analogs of indomethacin was synthesized and tested in vitro (at concentrations ranging from 10-9 to 10-5 mol/l) on human neutrophil functions. Two compounds lacking the carboxylic group were subjected to the same tests and one of these showed unexpected activity. Among the acidic derivatives, compound 12 bearing the same substituents as indomethacin 10 (methoxy and 4-chlorobenzoyl groups) was the most active: it significantly lowered neutrophil responses in all five bioassays and at the three concentrations considered.

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2

Hiromi, Sano, Mio Shigeru, Kumagawa Yuko, Kitagawa Junko, Shindou Masahiro, Honma Toyokuni, and Sugai Soji. "Synthesis and Herbicidal Activity of Opened Hydantoin-ring Derivatives of Hydantocidin." Bioscience, Biotechnology, and Biochemistry 60, no. 7 (January 1996): 1198–200. http://dx.doi.org/10.1271/bbb.60.1198.

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3

Angell, E. Charles, David St C. Black, and Naresh Kumar. "13C NMR study ofN-acyl- andN-sulphonyl-isatins and their ring-opened derivatives." Magnetic Resonance in Chemistry 30, no. 1 (January 1992): 1–5. http://dx.doi.org/10.1002/mrc.1260300102.

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Ramaswamy, Sowmianarayanan, and Allan C. Oehlschlager. "Efficient synthesis of exo- and endo-brevicomin from a single precursor." Canadian Journal of Chemistry 67, no. 5 (May 1, 1989): 794–96. http://dx.doi.org/10.1139/v89-120.

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Diastereoselective reduction of 2-propionyl-6-methyl-3,4-dihydropyran and its ring opened derivatives, followed by acidic work-up, gives mixtures rich (>9:1) of either exo- or endo-brevicomin. Keywords: exo- and endo-brevicomin, diastereoselective ketone reduction.

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5

HE, Huaizhen, Yingzhuan ZHAN, Jie ZHANG, and Tao WANG. "Synthesis and Anti-tumor Activities of Lactone Ring-Opened Taspine Coumarin Ester Fluorescent Derivatives." Acta Agronomica Sinica 29, no. 1 (2012): 75. http://dx.doi.org/10.3724/sp.j.1095.2011.00054.

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6

Song, Ming-Xia, Yu-Shan Huang, Qiu-Gui Zhou, Xian-Qing Deng, and Xiao-Dong Yao. "Synthesis of ring-opened derivatives of triazole-containing quinolinones and their antidepressant and anticonvulsant activities." Bioorganic Chemistry 106 (January 2021): 104505. http://dx.doi.org/10.1016/j.bioorg.2020.104505.

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7

Barak, Ruth, Adam Vincze, Peter Bel, S. P. Dutta, and Girish B. Chedda. "Mass spectrometric investigation of the presence of 7-methyl ring-opened guanine derivatives in urine." Chemico-Biological Interactions 86, no. 1 (January 1993): 29–40. http://dx.doi.org/10.1016/0009-2797(93)90109-c.

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8

Wagner, Gabriele, Uwe Verfürth, Rudolf Herrmann, and Carl Krüger. "Ring-Opening of (-)-Camphorsulfonimide Derivatives and (+)-Fenchonesulfonimide by Nitronium Tetrafluoroborate." Zeitschrift für Naturforschung B 49, no. 8 (August 1, 1994): 1150–58. http://dx.doi.org/10.1515/znb-1994-0822.

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Treating a derivative of (-)-camphorsulfonimide (CA name: (3aS)-8,8-dimethyl-4,5,6,7- tetrahydro-3H-3a.6-methano-2,1-benzisothiazole 2,2-dioxide) or the isomeric (+)-fenchonesulfonimide with nitronium tetrafluoroborate in acetonitrile does not lead to the expected products of cationic reactions, e.g. of the Ritter reaction for halogenated compounds, but provokes a cleavage of the sulfonimide group with the formation of a ring-opened product containing a sulfonyl fluoride and a nitroimine group. The reaction does occur only in the presence of solid nitronium tetrafluoroborate. but not after prior dissolution of the reagent. An X-ray structure of the product from (1 S)-3-endo-bromocamphorsulfonimide confirms this unusual reaction.

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9

Tudek, B., M. Graziewicz, O. Kazanova, T. H. Zastawny, T. Obtułowicz, and J. Laval. "Mutagenic specificity of imidazole ring-opened 7-methylpurines in M13mp18 phage DNA." Acta Biochimica Polonica 46, no. 3 (September 30, 1999): 785–99. http://dx.doi.org/10.18388/abp.1999_4151.

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The most abundant lesion formed in DNA upon modification with methylating agents 7-methylguanine, under alkaline conditions is converted into 2,6-diamino-4-hydroxy-5N-methyl-formamidopyrimidine (Fapy-7MeGua). We have previously shown that treatment of dimethylsulfate methylated DNA with NaOH creates mutagenic base derivatives leading to a 60-fold increase in the frequency of A-->G transitions and a 2-3-fold increase of G-->T and G-->C transversions. We have analyzed which lesions lead to these mutations. We compared mutagenic spectra in the lacZ gene of M13mp18 phage DNA modified with dimethylsulfate and NaOH after selective elimination of damaged bases from molecules used for transfection into SOS-induced E. coli. Partial elimination of Fapy-7MeGua from phage DNA performed by its digestion with formamidopyrimidine-DNA glycosylase resulted in a 2-3-fold decrease of G-->T and G-->C transversions. Selective depurination of methylated bases (9 h, 37 degrees C, pH 7.0) resulting in almost complete loss of 7MeAde as demonstrated by HPLC analysis of [3H]MNU alkylated phage DNA used as a probe, caused a dramatic, 9-fold decrease of A-->G transitions. Alkali-catalysed rearrangement of 7MeAde was followed by HPLC analysis of [3H]MNU alkylated poly(A) and poly(dA). After incubation of these oligonucleotides in NaOH, 7MeAde disappeared from both chromatograms, but only in polyA, 2 new peaks migrating with retention time different from that of 1MeAde, 3MeAde or 7MeAde were detected, suggesting formation of two rotameric forms of Fapy-7MeAde as observed for Fapy-7MeGua. Thus the miscoding lesion, giving rise to A-->G transitions derived from 7MeAde was Fapy-7MeAde. Fapy-7MeGua was at least an order of magnitude less mutagenic, but in SOS-induced cells it gave rise to G-->T and G-->C transversions.

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10

Beckett, Kirsten S., Justin G. Bendall, Richard C. Cambie, Peter S. Rutledge, Michael F. Walker, and Paul D. Woodgate. "Oxidation Products of Totara-8,11,13-trien-13-ol Derivatives." Australian Journal of Chemistry 50, no. 9 (1997): 933. http://dx.doi.org/10.1071/c96209.

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Reaction of 7-oxototara-8,11,13-trien-13-yl acetate (3) with acetic anhydride-perchloric acid affords the γ-pyrone (8) in addition to the previously reported acetyl derivative (4). Baeyer–Villiger oxidations of the ketones (3) or (5) have given starting material or complex mixtures, but the ε-lactone (9) and the rearranged product (11) were isolated from two experiments with (3). Oxidation of 13-methoxytotara-8,11,13-triene (2) with Jones reagent gives the 7-oxo derivative (5) and a low yield of a ring B opened substituted p-benzoquinone (13). Pathways to (11) and (13) are proposed.

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Dissertations / Theses on the topic "“Ring-opened” derivatives"

1

Mills, Judith Frances. "Kinetics and mechanism of the hydrolysis of benzoxazines and their ring opened derivatives." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267701.

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Silva, Maria José dos Santos Alves da. "Trypanothione Reductase: design of a potential new class of inhibitors." Master's thesis, 2016. http://hdl.handle.net/10451/35875.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016
Doenças tropicais como a doença de Chagas, doença do sono e leishmanioses são ainda importantes problemas de saúde pública a nível mundial. Nas últimas décadas tem-se assistido a um aperfeiçoamento do design e desenvolvimento de fármacos antiparasitários. O seu principal objetivo é ultrapassar as abordagens terapêuticas que são inadequadas face às populações alvo. Entre uma série de vias metabólicas específicas destes parasitas, o sistema Tripanotiona Reductase tem ganho uma crescente popularidade por ser o alvo mais conhecido e caracterizado até agora. Desde a descoberta da atividade antiparasitária de fármacos neuroléticos tricíclicos ao design dos protótipos “ring-opened” 2-aminodifenilsulfidos têm havido melhorias significativas no que diz respeito a aumento de atividade e de especificidade destas novas moléculas. Neste contexto, alguns derivados de 2-(feniltio)pirimidin-4--amina foram propostos como possíveis inibidores desta enzima crucial para a sobrevivência dos parasitas. Assim, estes derivados foram sintetisados e iniciaram-se algumas tentativas de melhorias nestas moléculas para serem depois testadas em ensaios enzimáticos e nos parasitas in vitro.
Tropical diseases like Chagas’ disease, sleeping sickness and leishmaniasis are still important public health issues worldwide. In the past few decades, there has been an improvement in design and development of antiparasitic drugs. With the main goal of overcoming the cubersome therapeutic approaches that are now applied in the field to the afflicted populations. Among the plethora of metabolic pathways unique to these parasites, Trypanothione-disulfide Reductase system has gained huge popularity as being the better characterized target available. From the discovery of antiparasitic activity of tricyclic neuroleptic drug to design of “ring-opened” 2-aminodiphenyl sulfide-based scaffolds there have been significant improvements concerning the increased activities and specificity of these novel scaffolds. In this field of interest, some 2-(phenylthio)pyrimidin-4-amine derivatives have been proposed to target this crucial enzyme to the parasites survival. That way, these derivatives have been synthesised and initial improvements were performed to be tested in vitro upon the Trypanothione Reductase enzyme and parasites.

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Book chapters on the topic "“Ring-opened” derivatives"

1

Taber, Douglass. "Alkene Metathesis: Synthesis of Panaxytriol (Lee), Isofagomine (Imahori and Takahata), Elatol (Stoltz), 5-F2t -Isoprostane (Snapper), and Ottelione B (Clive)." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0030.

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Alkene metathesis has been used to prepare more and more challenging natural products. The ﬁrst and second generation Grubbs catalysts 1 and 2 and the Hoveyda catalyst 3 are the most widely used. Daesung Lee of the University of Illinois at Chicago designed (Organic Lett. 2008, 10, 257) a clever chain-walking cross metathesis, combining 4 and 5 to make 6. The diyne 3 was carried on (3R, 9R, 10R )-Panaxytriol 7. Tatsushi Imahori and Hiroki Takahata of Tohoku Pharmaceutical University found (Tetrahedron Lett. 2008, 49, 265) that of the several derivatives investigated, the unprotected alcohol 8 cyclized most efficiently. Selective cleavage of the monosubstituted alkene followed by hydroboration delivered the alkaloid Isofagomine 10. Brian M. Stoltz of Caltech established (J. Am. Chem. Soc. 2008 , 130 , 810) the absolute configuration of the halogenated chamigrene Elatol 14 using the enantioselective enolate allylation that he had previously devised. A key feature of this synthesis was the stereocontrolled preparation of the cis bromohydrin. Marc L. Snapper of Boston College opened (J. Org. Chem. 2008, 73, 3754) the strained cyclobutene 15 with ethylene to give the diene 16. Remarkably, cross metathesis with 17 delivered 18 with high regioselectivity, setting the stage for the preparation of the 5-F2t - Isoprostane 19. Derrick L. J. Clive of the University of Alberta assembled (J. Org. Chem. 2008, 73, 3078) Ottelione B 26 from the enantiomerically-pure aldehyde 20. Conjugate addition of the Grignard reagent 21 derived from chloroprene gave the kinetic product 22, that was equilibrated to the more stable 23. Addition of vinyl Grignard followed by selective ring-closing metathesis then led to 26.

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