Academic literature on the topic 'RhoA'
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Journal articles on the topic "RhoA"
Saracaloglu, Ahmet, Seniz Demiryürek, Sabit Kimyon, Alper Mete, Ebru Temiz, Gülper Nacarkahya, Oguzhan Saygili, Kıvanc Güngör, and Abdullah Tuncay Demiryürek. "RHO Gene Polymorphisms in Patients with Pterygium." Proceedings 2, no. 25 (December 6, 2018): 1572. http://dx.doi.org/10.3390/proceedings2251572.
Full textGuasch, Rosa M., Peter Scambler, Gareth E. Jones, and Anne J. Ridley. "RhoE Regulates Actin Cytoskeleton Organization and Cell Migration." Molecular and Cellular Biology 18, no. 8 (August 1, 1998): 4761–71. http://dx.doi.org/10.1128/mcb.18.8.4761.
Full textKönigs, Volker, Richard Jennings, Thomas Vogl, Markus Horsthemke, Anne C. Bachg, Yan Xu, Kay Grobe, et al. "Mouse Macrophages Completely Lacking Rho Subfamily GTPases (RhoA, RhoB, and RhoC) Have Severe Lamellipodial Retraction Defects, but Robust Chemotactic Navigation and Altered Motility." Journal of Biological Chemistry 289, no. 44 (September 11, 2014): 30772–84. http://dx.doi.org/10.1074/jbc.m114.563270.
Full textHan, Jian, Li Li, Jiongyu Hu, Lili Yu, Yingru Zheng, Jianxin Guo, Xiuhui Zheng, Ping Yi, and Yuanguo Zhou. "Epidermal Growth Factor Stimulates Human Trophoblast Cell Migration through Rho A and Rho C Activation." Endocrinology 151, no. 4 (February 11, 2010): 1732–42. http://dx.doi.org/10.1210/en.2009-0845.
Full textTsubaki, Masanobu, Shuuji Genno, Tomoya Takeda, Takuya Matsuda, Naoto Kimura, Yuuma Yamashita, Yuusuke Morii, Kazunori Shimomura, and Shozo Nishida. "Rhosin Suppressed Tumor Cell Metastasis through Inhibition of Rho/YAP Pathway and Expression of RHAMM and CXCR4 in Melanoma and Breast Cancer Cells." Biomedicines 9, no. 1 (January 4, 2021): 35. http://dx.doi.org/10.3390/biomedicines9010035.
Full textTseliou, Melpomeni, Ahmed Al-Qahtani, Saud Alarifi, Saad H. Alkahtani, Christos Stournaras, and George Sourvinos. "The Role of RhoA, RhoB and RhoC GTPases in Cell Morphology, Proliferation and Migration in Human Cytomegalovirus (HCMV) Infected Glioblastoma Cells." Cellular Physiology and Biochemistry 38, no. 1 (2016): 94–109. http://dx.doi.org/10.1159/000438612.
Full textSaracaloglu, Ahmet, Seniz Demiryürek, Sabit Kimyon, Alper Mete, Ebru Temiz, Gülper Nacarkahya, Betül Düzen, Oguzhan Saygili, Kıvanc Güngör, and Abdullah Tuncay Demiryürek. "Protein Expressions of the Small GTPase Rho Proteins in Pterygial Tissue and Leukocytes of Patients with Pterygium." Proceedings 2, no. 25 (December 6, 2018): 1571. http://dx.doi.org/10.3390/proceedings2251571.
Full textJackson, Ben, Karine Peyrollier, Esben Pedersen, Astrid Basse, Richard Karlsson, Zhipeng Wang, Tine Lefever, et al. "RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes." Molecular Biology of the Cell 22, no. 5 (March 2011): 593–605. http://dx.doi.org/10.1091/mbc.e09-10-0859.
Full textRiento, Kirsi, Rosa M. Guasch, Ritu Garg, Boquan Jin, and Anne J. Ridley. "RhoE Binds to ROCK I and Inhibits Downstream Signaling." Molecular and Cellular Biology 23, no. 12 (June 15, 2003): 4219–29. http://dx.doi.org/10.1128/mcb.23.12.4219-4229.2003.
Full textPronk, Manon C. A., Jan S. M. van Bezu, Geerten P. van Nieuw Amerongen, Victor W. M. van Hinsbergh, and Peter L. Hordijk. "RhoA, RhoB and RhoC differentially regulate endothelial barrier function." Small GTPases 10, no. 6 (September 26, 2017): 466–84. http://dx.doi.org/10.1080/21541248.2017.1339767.
Full textDissertations / Theses on the topic "RhoA"
Chinestra, Patrick. "Conception de biosenseurs des protéines RhoA, RhoB, RhoC." Toulouse 3, 2012. http://thesesups.ups-tlse.fr/1715/.
Full textOur team is interested in understanding the mechanisms of deregulation of cell signaling pathways in the development and maintenance of tumor processes and their consequences in response to anti-tumor therapies. We focuse on Rho proteins as well as on their regulators. They are involved in signaling pathways of cell receptors leading to changes in adhesion, proliferation, motility and balance survival / cellular death. RhoA, RhoB and RhoC are small GTPases switching from an active state (GTP-bound) to an inactive state (GDP-bound) and the homology of which is close to 85%. Overexpression of RhoA and RhoC protein has been described in many tumors; in contrast, there was a decreased expression of RhoB in melanoma and lung cancer. Engineering antibody fragment specific of Rho active conformations, namely biosensors, would allow in situ assessment of these proteins activation in healthy or tumour samples. These tools could be further developed towards diagnosis or prognosis usage, or could even define novel therapeutics markers and be used to answer more fundamental question as their cellular localization, their role in cell migration, or their spatio-temporal activation. Starting from the scFvC1 previously isolated in the group and which is selective for RhoA, RhoB and RhoC active conformations, we have created by random mutagenesis a second library and performed a phage display selection with two aims: 1°) increase the C1 scFv affinity to enhance its interaction potential with active native Rho proteins in order to improve its performance in immuno-histology or to use it as an intracellular antibody. 2°) select variants with a selectivity towards strictly only one of the three Rho excluding the others despite their strong homology. We show that our strategy allowed an affinity increase of scFv and also a selectivity modulation as one variant preferentially binds RhoA and C. Moreover, in contrast to scFvC1 these scFvs immuno-precipitate active endogenous Rho Proteins in eukaryotic cells. In parallel, we have established a method allowing the labelling of an anti-RhoB scFv from the lab, by fusing it to an intein that induce covalent binding of a biotin fluorescent analogue. This approach will improve immuno-histological techniques using fluorescent biosensors
Huppertz, Tilman [Verfasser]. "Charakterisierung der Rekrutierungsdomäne der kleinen Rho-GTPasen RhoA und RhoC / Tilman Huppertz." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023697491/34.
Full textZandvakili, Inuk. "RhoA as a Potential Target in Lung Cancer." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1445342196.
Full textWill, Laura Christine [Verfasser]. "Charakterisierung der Interaktion von p120ctn mit den Rho-GTPasen RhoA und RhoC / Laura Christine Will." Gießen : Universitätsbibliothek, 2019. http://d-nb.info/1178320073/34.
Full textWill, Laura [Verfasser]. "Charakterisierung der Interaktion von p120ctn mit den Rho-GTPasen RhoA und RhoC / Laura Christine Will." Gießen : Universitätsbibliothek, 2019. http://d-nb.info/1178320073/34.
Full textSoliman, Hesham. "The RhoA/Rho kinase pathway in diabetic cardiomyopathy." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43439.
Full textSrivastava, Kirtiman. "Pathophysiological role of RhoA/Rho-kinase under oxygen-glucose deprivation/reperfusion and hyperglycaemia." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13533/.
Full textArd, Ryan. "Regulation of RhoA Activation and Actin Reorganization by Diacylglycerol Kinase." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22669.
Full textBendris, Nawal. "Nouvelles fonctions de la Cycline A2 : régulation de l’invasion cellulaire et de la transition épithéliomésenchymateuse." Thesis, Montpellier 2, 2011. http://www.theses.fr/2011MON20079.
Full textCancer aggressiveness is often associated with metastases occurrence and their dissemination can arise following an epithelial to mesenchymal transition (EMT). Cyclin A2 expression is lower in metastases relative to primary colon adenocarcinoma of matched human tumors. This manuscript describes new links between Cyclin A2 and Actin cytoskeleton remodeling in fibroblasts. This regulation requires a cytoplasmic localization of the protein and its N-terminal domain, which is unable to bind CDKs. This new Cyclin A2 activity appears to be mediated by its binding to RhoA. Accordingly, the activity of its GEF is potentiated when Cyclin A2 is present, in vitro. Furthermore, we used a normal mammary epithelial cell line and identified another Cyclin A2 partner, RhoC. Cyclin A2 depletion in this context leads to a reciprocal RhoGTPase activation where RhoA activation is impaired and that of RhoC is increased. Moreover, cell invasiveness is increased in a collagen matrix following Cyclin A2 knockdown in these cells. In addition, the epithelial cells acquire mesenchymal properties, which are exarcerbated by the expression of RasV12 and are characteristic of an EMT. Our work completes the network involving cell cycle proteins in motility. These novel functions of Cyclin A2 will hopefully help to understand the impact of its deregulation in cancer
Keller, Laura. "Conception de nano-anticorps conformationnels comme nouveaux outils d'étude de l'activité des GTPases de la sous-famille RHOA." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30005/document.
Full textRHOA small GTPase belongs to a subfamily acting as a molecular switch activating major signaling pathways that regulate cytoskeletal dynamics and a variety of cellular responses such as cell cycle progression, cytokinesis, migration and polarity. RHOA activity resides in a few percent of GTP loaded protein, which is finely tuned by a crosstalk between regulators of the GTPase cycle. Manipulating a single RHO at the expression level often induces imbalance in the activity of other RHO GTPases, suggesting that more specific tools targeting these active pools are needed to decipher RHOA functions in time and space. We decided to use single domain antibodies, also known as VHH or nanobodies, as a new tool for studying RHOA activation. We produced and screened a novel fully synthetic phage display library of humanized nanobodies (NaLi-H1) to develop conformational sensors of the GTP loaded active conformation of RHO subfamily. We obtained several high affinity nanobodies against RHOA's active form which we characterized as RHO active antibodies in vitro and RHO signaling blocking intrabodies in cellulo. These new tools will facilitate and improve our current knowledge of this peculiar protein subfamily and will be a paradigm for the study of other RHO related small GTPases
Books on the topic "RhoA"
Krepinsky, Joan Caroline. Nitric oxide inhibits stretch-induced MAPK activation in mesangial cells through RhoA inactivation. Ottawa: National Library of Canada, 2003.
Find full textSiegert, Peter. Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gaq/11 - p63RhoGEF - RhoA axis. Freiburg: Universität, 2013.
Find full textRempel, Byron. No limits: The amazing life story of Rhona and Rhoda Wurtele : Canada's olympian skiing pioneers. [Westmount, QC?]: Twinski Publications, 2007.
Find full textSociété d'histoire et de généalogie des Pays-d'en-Haut, ed. No limits: The amazing life story of Rhona and Rhoda Wurtele, Canada's olympian skiing pioneers. 2nd ed. [Montréal]: Éditions Histoire Québec, 2009.
Find full textJohnson, Clifford. What is a rhea? Wisconsin Rapids, WI (3824 St. John's Rd., Wisconsin Rapids 54494): Design Wise Graphics, 1991.
Find full textClifford, Johnson. What is a rhea? 2nd ed. Stevens Point, WI (330 W. Cedar St., Stevens Point 54481): Design Works Graphics, 1994.
Find full textLittle, Jean. Stanley & Rhoda. London: Picture Lions, 1992.
Find full textSociété d'histoire et de généalogie des Pays-d'en-Haut, ed. Sans limites: La vie exceptionnelle des jumelles Rhona et Rhoda Wurtele, olympiennes et pionnières du ski au Canada. 2nd ed. [Montréal]: Éditions Histoire Québec, 2009.
Find full textAskevold, David. Rhea ; Jumped out. Toronto: Trinity Square Video, 1986.
Find full textLittle, Jean. Stanley and Rhoda. London: Collins, 1991.
Find full textBook chapters on the topic "RhoA"
Orgaz, Jose L., and Victoria Sanz-Moreno. "RhoA." In Encyclopedia of Signaling Molecules, 4681–91. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101793.
Full textOrgaz, Jose L., and Victoria Sanz-Moreno. "RhoA." In Encyclopedia of Signaling Molecules, 1–11. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101793-1.
Full textHair, Joseph F., G. Tomas M. Hult, Christian M. Ringle, Marko Sarstedt, Nicholas P. Danks, and Soumya Ray. "Evaluation of Reflective Measurement Models." In Classroom Companion: Business, 75–90. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80519-7_4.
Full textTabit, Corey E., Qing Mei Wang, Robert Y. L. Zee, and James K. Liao. "RhoA/Rho-Associated Kinase as Marker of Cardiovascular Health." In Biomarkers in Cardiovascular Disease, 739–69. Dordrecht: Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-007-7678-4_17.
Full textLiao, James K., Qing Mei Wang, Robert Y. L. Zee, and Corey E. Tabit. "RhoA/Rho-Associated Kinase as Marker of Cardiovascular Health." In Biomarkers in Cardiovascular Disease, 1–31. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-007-7741-5_17-1.
Full textSajib, Md S., Fatema T. Zahra, Racheal G. Akwii, and Constantinos M. Mikelis. "Identification of Rho GEF and RhoA Activation by Pull-Down Assays." In Methods in Molecular Biology, 97–109. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0845-6_10.
Full textLiu, Yianzhu, Jacek Z. Kubiak, Xian C. Li, Rafik M. Ghobrial, and Malgorzata Kloc. "Macrophages and RhoA Pathway in Transplanted Organs." In Results and Problems in Cell Differentiation, 365–76. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-54090-0_15.
Full textSantiago-Lopez, Angel J., Claire-Anne Gutekunst, and Robert E. Gross. "C3 Transferase Gene Therapy for Continuous RhoA Inhibition." In Methods in Molecular Biology, 267–81. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8612-5_19.
Full textIto, Satoru. "Role of RhoA/Rho-kinase and Calcium Sensitivity in Airway Smooth Muscle Functions." In Calcium Signaling In Airway Smooth Muscle Cells, 285–307. Cham: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-01312-1_15.
Full textKloc, Malgorzata, Ahmed Uosef, Jarek Wosik, Jacek Z. Kubiak, and Rafik Mark Ghobrial. "RhoA Pathway and Actin Regulation of the Golgi/Centriole Complex." In Results and Problems in Cell Differentiation, 81–93. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-23173-6_5.
Full textConference papers on the topic "RhoA"
Na, Sungsoo. "Engineering Tools for Studying Coordination Between Biochemical and Biomechanical Activities in Cell Migration." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53709.
Full textDuong-Quy, Sy, Thong Hua-Huy, Pierre Dao, Nhat-Nam Le-Dong, and Anh Tuan Dinh-Xuan. "Downregulation Of ENOS Expression And Activity by RhoA/Rho-kinase Pathway In Moderate COPD Patients." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5247.
Full textOsterziel, Richard, Michael Döbrönti, Anja Schulz-Kuhnt, Cord Brakebusch, Rocío López-Posadas, Stefan Wirtz, Markus Neurath, and Imke Atreya. "ILC2s in der mukosalen Entzündung: Fehlender Einfluss der kleinen Rho GTPasen Rac1, RhoA und Cdc42." In 50. Jahrestagung der Gesellschaft für Gastroenterologie in Bayern e.V. Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1764098.
Full textRyu, Byung-Kyu, Min-Goo Lee, Min-Ju Kang, Tae-Kyu Ha, Jikhyon Han, Nam-Gu Her, Seong-In Chung, and Sung-Gil Chi. "Abstract 5068: Identification of RASSF1A as a novel RhoA antagonist: direct interaction with and Smurf1-mediated ubiquitination of RhoA." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-5068.
Full textMillar, Fraser, Robert Hynds, Kate Gowers, Colin Butler, Laura Succony, Krishna Kolluri, Samuel Janes, and Adam Giangreco. "LSC Abstract – Human bronchial epithelial cell migration is dependent on the RhoA effector protein Rho-associated kinase." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pp217.
Full textBelaid, Amine, Papa Diogop N'diaye, Michaël Cerezo, Patrick Brest, Daniel J. Klionsky, Georges F. Carle, Paul Hofman, and Baharia Mograbi. "Abstract A224: Autophagy and SQSTM1 on the RHOA(d) again." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-a224.
Full textSchaafsma, Dedmer, Sarah A. Maltby, Behzad Yeganeh, Sujata Basu, Karol D. McNeill, Gerald L. Stelmack, Helmut Unruh, and Andrew J. Halayko. "The RhoA-Rho Kinase Axis Contributes To Hyperreactivity Of Airway Smooth Muscle From Allergen Naive Caveolin-1 Knockout Mice." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4127.
Full textRodrigues, Paulo, Irati Macaya, Sarah Bazzocco, Elena Andretta, Rocco Mazzolini, Higinio Dopeso, Silvia Mateo-Lozano, et al. "Abstract 2058: RHOA inactivation enhances Wnt signaling and promotes colorectal cancer." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2058.
Full textMisek, Sean A., Kathleen A. Gallo, and Richard R. Neubig. "Abstract 5895: Targeting RhoA-regulated gene transcription in drug-resistant melanoma." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-5895.
Full textRackow, A. R., G. Zapas, R. Clough, and R. M. Kottmann. "Activation of TDAG8 Prevents Myofibroblast Differentiation via Inhibition of RhoA Signaling." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4413.
Full textReports on the topic "RhoA"
Falk, A. Comment on Extracting alpha from B to rho rho. Office of Scientific and Technical Information (OSTI), October 2003. http://dx.doi.org/10.2172/826521.
Full textBevan, A. Measurements of sin2 alpha phi_2 from B to pi pi, rho pi and rho rho Modes. Office of Scientific and Technical Information (OSTI), November 2004. http://dx.doi.org/10.2172/839802.
Full textAubert, B. Observation of e+e- Annihilations into the C=+1 Hadronic Final States \rho^0\rho^0 and \phi\rho^0. Office of Scientific and Technical Information (OSTI), June 2006. http://dx.doi.org/10.2172/885278.
Full textLi, H. Constraints on the CKM Angle alpha in the B to rho rho Decays. Office of Scientific and Technical Information (OSTI), November 2004. http://dx.doi.org/10.2172/839589.
Full textAubert, B. Improved Measurement of the CKM Angle alpha Using B0 to rho+rho- Decays. Office of Scientific and Technical Information (OSTI), March 2005. http://dx.doi.org/10.2172/839874.
Full textAubert, B. Search for the Decay B{sup 0} --> {rho}{sup 0} {rho}{sup 0}. Office of Scientific and Technical Information (OSTI), August 2004. http://dx.doi.org/10.2172/829731.
Full textKamasani, Uma R., and George Prendergast. Mechanism of RhoB/FTI Action in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, May 2004. http://dx.doi.org/10.21236/ada446332.
Full textRane, Neena S., and George C. Prendergast. Mechanism of RhoB/FTI Action in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, May 2002. http://dx.doi.org/10.21236/ada412302.
Full textCorbin, D. R., M. M. Eddy, L. Abrams, G. A. Jones, and G. D. Stucky. Flexibility of the Zeolite RHO Framework. Neutron Powder Structural Characterization of Ca-Exchanged Zeolite RHO. Fort Belvoir, VA: Defense Technical Information Center, July 1988. http://dx.doi.org/10.21236/ada197195.
Full textJessop, Colin P. Study of B -> psi rho. Office of Scientific and Technical Information (OSTI), June 2003. http://dx.doi.org/10.2172/813223.
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