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1
Genth, E. "Rheumatoide Arthritis. Rheumatoid Arthritis." Laboratoriums Medizin 26, no. 3-4 (April 2002): 130–36. http://dx.doi.org/10.1046/j.1439-0477.2002.02025.x.
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Genth, E. "Rheumatoide Arthritis/Rheumatoid Arthritis." LaboratoriumsMedizin 26, no. 3/4 (January 1, 2002): 130–36. http://dx.doi.org/10.1515/labmed.2002.018.
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Septiani, Febi, Indri Heri Susanti, Silvi Yuanita, Nurun Nabila, Putri Aziizah Thurfah, Putri Sella Adelia, Riang Gumanti, Rifmawati Widya Pratami, Salsabila Saputri, and Satria Tegar Baratha Yuda. "Pendidikan Kesehatan tentang Rhematoid Arthritis dan Senam Rematik Pada Lansia di Posyandu Lansia Mugi Sehat." Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) 7, no. 3 (March 1, 2024): 1401–7. http://dx.doi.org/10.33024/jkpm.v7i3.14032.
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ABSTRAK Prevalensi rheumatoid arthritis berdasarkan diagnosis tenaga kesehatan di Indonesia adalah 11,9% berdasarkan diagnosis atau gejala adalah 24,7%. Prevalensi berdasarkan usia penderita rheumatoid arthritis 45-54 tahun mencapai 37,2%, usia 55-64 tahun sebanyak 45,0%, usia 65-74 tahun sebanyak 51,9% dan usia lebih dari 75 tahun mencapai 54,8%. Rheumatoid arthritis penyakit yang menyerang pada bagian sendi sehingga mengakibatkan struktur ataupun jaringan terganggu sehingga mengganggu aktifitas sehari-hari. Untuk mengurangi nyeri sendi yang dialami penderita dapat dilakukan dengan non farmakologi yaitu dengan senam rematik. Kegiatan pengabdian masyarakat bertujuan untuk memberikan pemahaman dan pencegahan penyakit Rheumatoid arthritis pada lansia di Posyandu Mugi Sehat. Metode yang digunakan dalam kegiatan ini yaitu penyuluhan kesehatan dengan metode ceramah, diskusi, tanya jawab, dan praktik senam rematik. Pasca pengabdian masyarakat diketahui bahwa peserta mengalami peningkatan pengetahuan terkait dengan Rheumatoid arthritis. Kegiatan pengabdian masyarakat penting dilakukan untuk meningkatkan pengetahuan masyarakat terkait berbagai penyakit dan meningkatkan kesadaran masyarakat akan pentingnya pencegahan penyakit rheumatoid arthritis sehingga dapat mengurangi tingkat kesakitan dan menurunkan prevalensi rheumatoid arthritis di Indonesia sendiri. Kata Kunci: Pencegahan, Rheumatoid Arthritis, Senam Rematik ABSTRACT The prevalence of rheumatoid arthritis based on diagnosis by health workers in Indonesia is 11.9% based on diagnosis or symptoms is 24.7%. The prevalence based on rheumatoid arthritis sufferers aged 45-54 years reached 37.2%, aged 55-64 years was 45.0%, aged 65-74 years was 51.9% and aged over 75 years reached 54.8%. Rheumatoid arthritis, also known as rheumatic disease, is inflammation of the joints which causes the structure or tissue around it to become disturbed, which causes daily activities to be disrupted. To reduce joint pain experienced by sufferers, it can be done non-pharmacological, namely rheumatic exercises. Community service activities aim to provide an understanding and prevention of rheumatoid arthritis in the elderly at Posyandu Mugi Sehat.The method used in this activity is health education using lecture, discussion, question and answer methods, and rheumatic exercise practice. After community service, it was discovered that participants experienced increased knowledge related to Rheumatoid arthritis. It is important to carry out community service activities to increase public knowledge regarding various diseases and increase public awareness of the importance of preventing rheumatoid arthritis so that it can reduce the level of morbidity and reduce the prevalence of rheumatoid arthritis in Indonesia itself. Keywords: Prevention, Rheumatoid Arthritis, Rheumatic Exercise
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Kazmi, Zehra. "The Influence of Early Menopause in Women with Rheumatoid Arthritis; A Systematic Review." Healer Journal of Physiotherapy and Rehabilitation Sciences 1, no. 1 (June 30, 2021): 27–37. http://dx.doi.org/10.55735/thjprs.v1i1.22.
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Background: Rheumatoid arthritis is a chronic disease affecting the immune system and it particularly targets synovial joints, bringing about inflammation and causing functional limitations. Objective: To explore the evidence showing the influence of early menopause in women with rheumatoid arthritis. Methods: In this systematic review, all the literature from 2010 to 2019 was searched with specific keywords “menopause, premature menopause, early menopause, rheumatoid arthritis, rheumatic diseases” with the use of Boolean operators. Databases that were thoroughly searched included Google Scholar, PubMed and HEC digital library. After careful screening, 10 studies that met the inclusion criteria were included in the review. The quality of these articles was assessed using the AXIS tool for that cross-sectional studies. Results: These studies indicated that post-menopausal women are at higher risk of developing rheumatoid arthritis and they are more likely to have early or premature menopause (in ≤45 years). At baseline, the post-menopausal women had high health assessment questionnaire scores than pre-menopausal women. Conclusion: This review states that menopausal women are highly at risk of developing rheumatoid arthritis, especially those experiencing this at an early age and this condition can also worsen arthritic symptoms. Hormonal changes may influence pathways that are distinct from those leading to severe and progressive rheumatoid arthritis.
*Corresponding author: Zehra Kazmi, University Institute of Physical Therapy, University of Lahore, Lahore, Pakistan; Email: zaza.kazmi110@gmail.com
Citation: Kazmi Z. 2021. The influence of early menopause in women with rheumatoid arthritis; a systematic review. The Healer Journal of Physiotherapy and Rehabilitation Sciences, 1(1):27-37.
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Wekoadi, Galih Mahendra, and Budi Widiyanto. "Management of Non Pharmacological Pain in Clients With Rheumathoid Arthritis : A Literature Review." Journal of Applied Health Management and Technology 2, no. 3 (July 31, 2020): 104–15. http://dx.doi.org/10.31983/jahmt.v2i3.5725.
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Rheumathoid Arthritis is a disease that occurs due to abnormalities in the joints, causing pain and stiffness in the musculoskeletal system such as skeletal muscles, joints, ligaments and bones and generally attacks clients over the age of 40 years (Syapitri, 2018). Rheumatoid Arthritis has typical symptoms in sufferers, one of which is pain. If not handled properly, pain in rheumathoid arthritis can disrupt the activities of sufferers, paralysis and impaired balance. Therefore, pain in reumathoid arthritis must be treated. The aim of writing this literature review is to provide information about the non-pharmacological management of pain in clients with rheumatoid arthritis. The method used in this study is to use the Literature review method. Literature review is carried out by analyzing articles relevant to the title taken, namely the management of non-pharmacological pain in clients with Rheumathoid arthritis. The stages in conducting a Literature review are based on 5 stages of literature review that cover the eligibility criteria, information sources, selection of literature, data collection and selection of data items. With pain rheumatic arthritis include: back massage, cupping, benson relaxation and warm compresses, cinnamon compresses, giving of the gnome, ginger compresses, lemongrass compresses, Swedish massases, giving keroncong music, grated ginger grater, tai chi exercise, and yoga interventions.
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Tri Novana, Vanesa, Firman Faradisi, and Nuniek Nizmah Fajriyah. "Pengaruh Senam Rematik Terhadap Penurunan Nyeri Pada Pasien Rheumatoid Arthritis." Prosiding Seminar Nasional Kesehatan 1 (December 23, 2021): 2084–89. http://dx.doi.org/10.48144/prosiding.v1i.977.
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Abstract Rheumatoid arthritis is an autoimmune disease when a person’s immune system attacks the body’s cells. Signs and symptoms of rheumatoid arthritis include joint inflammation and joint deformity. In most cases, patients with rheumatoid arthritis experience joint pain. Rheumatic Gymnastics is an alternative therapy that has been proven to reduce joint pain in rheumatic patients. The purpose of this case study is to describe the use of rheumatic exercise therapy in arthritic patients. The purpose of this case study is to examine therapeutic gymnastic in reducing pain among patients with rheumatoid arthritis. Two patients were taught to exercise therapeutic gymnastic. The research instrument is a pain scale observation sheet (Numerical Rating Scale). Two patients reported that there was a decreasing intensity of joint pain after doing exercise. This study concludes this particular exercise may reduce joint pain. Nurses are suggested to implement therapeutic gymnastics exercise in reducing pain among patients with Rheumatoid arthritis.Keywords : rheumatoid arthritis; pain; therapeutic gymnastics exercise
Abstrak Rematik merupakan penyakit auto imun ketika sistem imun pada tubuh seseorang menyerang sel-sel tubuhnya sendiri. Gejala rematik yaitu inflamasi, deformitas, dan nyeri sendi yang paling dirasakan oleh penderita rematik. Senam Rematik merupakan terapi alternative yang sudah terbukti dapat menurunkan nyeri sendi pada pasien rematik. Tujuan studi kasus ini adalah untuk menggambarkan penggunaan terapi senam rematik pada pasien rematik. Metode yang digunakan adalah asuhan keperawatan dengan menerapkan terapi senam rematik. Instrumen penelitian berupa lembar observasi skala nyeri (Numerical Rating Scale). Hasil yang didapatkan pada klien 1 maupun 2 yaitu mengalami penurunan nyeri. Kesimpulan pada studi kasus ini bahwa senam rematik dapat menurunkan skala nyeri. Saran bagi perawat diharapkan dapat menerapkan tindakan senam rematik untuk menurunkan skala nyeri pada pasien rematik.Kata kunci : Rematik, nyeri, senam rematik
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Wulandari, Sri, Warda Anil Masyayih, Rista Dian Anggraini, and Hany Puspita Aryani. "Hubungan Rheumatoid Arthritis dengan Kejadian Insomnia pada Usia Lanjut." Journal of Holistics and Health Science 5, no. 1 (March 9, 2023): 45–54. http://dx.doi.org/10.35473/jhhs.v5i1.256.
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One of the health problems often experienced by the elderly is rheumatoid arthritis. Joint disorders experienced by people with rheumatoid arthritis will have an impact on physical problems such as insomnia and will later affect sleep quality. Design correlational analytical research with a cross-sectional approach. The sample was all elderly people with rheumatoid arthritis as many as 30 respondents using the smapling purposive sampling technique. Data collection using KSPBJ insomnia rating scale questionnaires. Analyse data with Spearman’s Rho test with 0.05 significance. The results of the study were known that in respondents who experienced rheumatoid arthritis with severe pain all experienced severe insomnia, which was 13.3%. Meanwhile, in respondents who experienced rheumatoid arthritis with mild pain, all experienced mild insomnia, which was 36.7%. The results of the data analysis with the Spearman Rho test found that there was a relationship between rheumatoid arthritis and insomnia in old age in Kreteranggon Village, Sambeng District, Lamongan Regency (ρ =0,000, α=0.05, r=0.699). Based on the description above, it can be concluded that there is a relationship in the strong category between rheumathoid arthritis and the incidence of insomnia. ABSTRAK Salah satu masalah kesehatan yang sering dialami oleh lansia adalah rheumatoid arthritis. Gangguan sendi yang dialami penderita rheumatoid arthritis akan berdampak pada masalah fisik seperti insomnia dan nantinya akan berpengaruh pada kualitas tidur. Rancangan penelitian analitik korelasional dengan pendekatan cross sectional. Sampelnya semua lansia penderita penyakit rheumatoid arthritis sebanyak 30 responden dengan menggunakan teknik sampling purposive sampling. Pengumpulan data menggunakan kuesioner KSPBJ insomnia rating scale. Analisa data dengan uji Spearman’s Rho dengan signifikasi 0,05. Hasil Penelitian diketahui bahwa pada responden yang mengalami rheumatoid arthritis dengan nyeri berat seluruhnya mengalami insomnia berat yaitu sebanyak 13,3%. Sedangkan pada responden yang mengalami rheumatoid arthritis dengan nyeri ringan seluruhnya mengalami insomnia ringan yaitu sebanyak 36,7%. Hasil analisa data dengan uji Spearman Rho didapatkan ada hubungan rheumatoid arthritis dengan kejadian insomnia pada usia lanjut di Desa Kreteranggon Kecamatan Sambeng Kabupaten Lamongan ( ρ =0,000, α=0,05, r=0,699). Berdasarkan uraian diatas dapat disimpulkan bahwa Ada hubungan dalam kategori kuat antara rheumathoid Arthritis dengan kejadian insomnia.
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Chaudhary, Archana, and Pandit Vinay. "Rheumatoid Arthritis: Etiology, Treatment and Animal Models." Journal of Drug Delivery and Therapeutics 10, no. 5-s (October 15, 2020): 290–98. http://dx.doi.org/10.22270/jddt.v10i5-s.4357.
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Rheumatoid arthritis is an autoimmune disease that can cause joint pain and damage throughout your body. About 75% of Rheumatoid arthritis patients are women. In fact, 1 – 3% of women may get rheumatoid arthritis in their lifetime. The disease most often begins between the ages of 30 and 50. Rheumatoid arthritis occurs when your immune system attacks the synovium, the lining of the membranes that surround your joints. The resulting inflammation thickens the synovium, which can eventually destroy the cartilage and bone within the joint. The tendons and ligaments that hold the joint together weaken and stretch. Gradually, the joint loses its shape and alignment. It also affects other organs of body like: skin, eyes, heart, kidneys, and lungs. The main risk factors that cause Rheumatoid arthritis are Age, Gender, Genetics, weight, smoking, diet, etc. Three main ways to treat rheumatoid arthritis are Drugs, physical therapies and surgery. There are four main groups of drugs that are used to treat rheumatoid arthritis are non-steroidal anti-inflammatory drugs , disease-modifying anti-rheumatic drugs and steroids (also known as corticosteroids). Collagen induced arthritis and Adjuvant arthritis are the most commonly used standard animal models in Rheumatoid arthritis. This literature review assessed the sign & symptoms, risk factors, etiology, treatment and standard animal models for Rheumatoid arthritis.
Keywords: Rheumatoid arthritis, Inflammation, Antirheumatic drugs, Adjuvants, Rat, Mice.
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Konyshevskaya, A. A., N. V. Vaizer, and L. P. Shelestova. "Clinical characteristic of juvenile rheumatoid arthritis debut and course." Likarska sprava, no. 5-6 (September 30, 2017): 143–49. http://dx.doi.org/10.31640/ls-2017(5-6)26.
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The article is devoted to juvenile rheumatoid arthritis – one of the most common rheumatic diseases with children. High activity and aggressive course of juvenile rheumatoid arthritis are common with children with systemic and polyarticular disease variants debut. The article presents case studies of children with systemic and polyarticular variants debut of juvenile rheumatoid arthritis.
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Nurfatimah, Nurfatimah, Audina Audina, and Kadar Ramadhan. "PENERAPAN TEKNIK KOMPRES HANGAT JAHE TERHADAP PENGENDALIAN LEVEL NYERI DENGAN KASUS RHEUMATOID ARTRITIS." Jurnal Kesehatan 12, no. 1 (May 14, 2024): 34–42. http://dx.doi.org/10.32763/kqhk9r97.
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Rheumatoid arthritis merupakan salah satu penyakit autoimun yang berupa inflamasi arthritis pada pasien dewasa, seseorang yang menderita penyakit Rheumatoid Arthritis akan mengalami gejala berupa rasa nyeri pada bagian sinovial sendi. Berdasarkan data dari Puskesmas Mapane penderita rheumatoid arthritis tahun 2016 sebanyak 422 orang dan meningkat pada tahun 2017 menjadi 613 pasien. Penelitian ini bertujuan untuk menerapkan teknik kompres hangat terhadap pengendalian level nyeri pada asuhan keperawatan gerontik dengan kasus rheumatoid arthritis. Metode dalam penelitian ini yaitu studi kasus pada penderita rheumatoid arthritis dengan tindakan penerapan teknik kompres hangat jahe untuk mengendalikan level nyeri. Hasil terdapat pengaruh kompres hangat jahe dalam menurunkan nyeri rheumathoid arthritis dari skala 6 menjadi skala 3. Terapi kompres hangat jahe dengan 3 kali pemberian pada pagi hari selama 1 minggu dalam waktu 20 menit dapat menurunkan nyeri lutut. Kesimpulan pemberian terapi kompres hangat jahe dengan 3 kali pemberian selama 1 minggu dalam waktu 20 menit dapat menurunkan nyeri lutut.
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Dariushnejad, Hassan, Leila Chodari, Mehrnoosh Sedighi, Soheila Akbari, and Vajihe Ghorbanzadeh. "Rheumatoid arthritis: current therapeutics compendium." Endocrine Regulations 56, no. 2 (April 1, 2022): 148–62. http://dx.doi.org/10.2478/enr-2022-0016.
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Abstract Rheumatoid arthritis is a common chronic inflammatory disease with substantial economic, social, and personal costs. Its pathogenesis is multifactorial and complex. The ultimate goal of rheumatoid arthritis treatment is stopping or slowing down the disease progression. In the past two decades, invention of new medicines, especially biologic agents, revolutionized the management of this disease. These agents have been associated with an improved prognosis and clinical remission, especially in patients who did not respond to traditional disease-modifying anti-rheumatic drugs (DMARDs). Improvement in the understanding of the rheumatoid arthritis pathogenesis leads to the development of novel biologic therapeutic approaches. In the present paper, we summarized the current therapeutics, especially biologic agents, available for the treatment of rheumatoid arthritis.
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Tkachenko, L. A., U. A. Kostrikova, T. I. Yarmola, G. L. Pustovoit, and V. V. Talash. "KIDNEY DAMAGE IN PATIENTS WITH RHEUMATOID ARTHRITIS." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 19, no. 2 (July 19, 2019): 246–50. http://dx.doi.org/10.31718/2077-1096.19.2.246.
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The purpose of this work is to perform a general analysis of relevant literature on the issue of kidney damage in patients with rheumatoid arthritis. Kidney damage in patients with rheumatic diseases is potentially dangerous, as it can lead to the development of terminal renal failure that may require replacement renal therapy. Amyloidosis often leads to kidney failure in patients with rheumatoid arthritis. Renal amyloidosis more often develops in patients with acute course of rheumatoid arthritis and under maximal immunological disorders. In patients with renal amyloidosis against the background of rheumatoid arthritis, manifestations of joint affection decrease, while the renal-uremic syndrome takes a predominant role. Signs of nephrotic syndrome and chronic renal failure develop gradually. Kidney damage can be caused by medications for rheumatoid arthritis. The choice of the optimal scheme of individual-centred therapy is vitally important for patients, since every aggravation of both rheumatic disease and secondary renal damage leads to the progression of chronic renal failure.
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Isrofah, Isrofah, and Irine Dwitasari Wulandari. "Empowerment of Rheumatoid arthritis sufferers through anti-rheumatism geriatric classes." Community Empowerment 8, no. 7 (July 31, 2023): 1011–16. http://dx.doi.org/10.31603/ce.8877.
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The elderly is at risk of experiencing degenerative diseases compared to young people, one of which is Rheumatoid Arthritis. Rheumatoid Arthritis is a degenerative disease of the joints that can cause pain and stiffness and is still a major health problem in the world today. The aim of implementing this program is to educate the public about the correct management of Rheumatoid Arthritis so that they can avoid the adverse effects of joint pain and swelling, relieve stiffness and prevent joint damage. This program is carried out in the form of education and anti-rheumatic gymnastics. The results of this community service show an increase in partners' knowledge about efforts to prevent Rheumatoid Arthritis after education and practice of anti-rheumatic gymnastics.
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Meenu, Mishra, Sharma Chetan, and Sharma Shraddha. "Vivid Action of Simhanada Guggulu in the Management of Amavata (Rheumatoid Arthritis): A Review." International Journal of Health Sciences and Research 11, no. 6 (June 10, 2021): 126–29. http://dx.doi.org/10.52403/ijhsr.20210617.
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Introduction: Rheumatoid Arthritis is a common form of inflammatory arthritis, occurring throughout the world and in all ethnic groups and affects approximately 1% of the population worldwide. In Ayurveda Amavata has a high resemblance to Rheumatoid Arthritis. Acharya Madhavakar was the first to give a detailed description of Amavata. Modern treatment of Rheumatoid Arthritis is not satisfactory therefore Ayurvedic medicines are the need of the hour. Aim & Objectives: To explore the mode of action of Simhanada Guggulu and to aware about medicinal properties and encourage the use of Simhanada Guggulu in the management of Amavata (Rheumatoid Arthritis). Materials and Methods: For this study Ayurveda Samhitas, authentic publications, internet and modern medical literature have been reviewed. Conclusion: The Simhanada Guggulu is Kaphavatahara, Pittavardhaka, Agnideepaka and Amapachaka. Thecontents of Simhanada Guggulu may act as Disease Modifying Anti Rheumatic Drugs (DMARDS). So it is concluded that Simhanada Guggulu can be used as an effective Ayurvedic medicine for Amavata (Rheumatoid Arthritis). Key words: Simhanada Guggulu, Rheumatoid Arthritis, Amavata.
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Iordache, Cristina, Bogdan Vascu, Eugen Ancuta, Rodica Chirieac, Cristina Pomirleanu, and Codrina Ancuta. "Immuno-biological Assessments of Temporomandibular Joint Disease in Patients with Immune-mediated Rheumatic Conditions. A cross sectional study of 273 cases." Revista de Chimie 68, no. 12 (January 15, 2018): 2987–91. http://dx.doi.org/10.37358/rc.17.12.6023.
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Temporomandibular joint (TMJ) is commonly involved in various immune-mediated rheumatic disorders accounting for significant disability and impaired quality of life. The aim of our study was to assess inflammatory and immune parameters in patients with TMJ arthritis related to rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) and to identify potential relation with severity and dysfunction of TMJ pathology. We performed a cross-sectional study in a cohort of 433 consecutive RA, 32 JIA, 258 AS, and 103 PsA. Only patients presenting with clinically significant TMJ involvement (273) related to their rheumatic condition were included in the final analysis. TMJ involvement is traditionally described in chronic inflammatory rheumatic disorders, particularly in patients with higher levels of inflammation as detected in rheumatoid arthritis and psoriatic arthritis. Disease activity and severity, as well as biological and positive serological assessments (rheumatoid factor, anti-cyclic citrullinated peptide, IL-1) remain significant determinants of the severity of TMJ arthritis.
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Riccio, A., and G. Tarantino. "Hepatitis C Virus-Related Arthtitis and Rheumatoid Arthritis: Could They Be Different Aspects of the Same Disease?" International Journal of Immunopathology and Pharmacology 25, no. 1 (January 2012): 293–96. http://dx.doi.org/10.1177/039463201202500134.
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The role played by HCV in the genesis of many autoimmune disorders has been reported in several studies. In particular, the onset of arthritis has been described in about 2–3% of HCV infection cases. At present, this HCV-related arthritis is classified as a reactive arthritis, but a real distinction of this form from classical rheumatoid arthritis is often difficult. In this presentation, the Authors distinguish two arthritic forms observed in HCV-related arthritis patients: one, characterized by asymmetrical oligoarticular-involvement, and another, with poly-articular symmetrical involvement. The Authors suggest that the latter can be considered as a form of rheumatoid arthritis, because of the similarity of the main clinical aspects and laboratory findings (rheumatoid factor, anti-cyclic citrullinated peptide antibodies) to those of classical rheumatoid arthritis, which make the two forms indistinguishable. Therefore, HCV could be considered the etiologic agent of a limited number of cases of rheumatoid arthritis.
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Ciofoaia, Elena I., Anjani Pillarisetty, and Florina Constantinescu. "Health disparities in rheumatoid arthritis." Therapeutic Advances in Musculoskeletal Disease 14 (January 2022): 1759720X2211371. http://dx.doi.org/10.1177/1759720x221137127.
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Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation that involves symmetric polyarthritis of small and large joints. Autoimmune rheumatic diseases represent a significant socioeconomic burden as they are among the leading causes of death and morbidity due to increased risk of cardiovascular disease. Health disparities in patients with rheumatoid arthritis affect outcomes, prognosis, and management of the disease.
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Djunarko, Ipang, Nanang Fakhrudin, Arief Nurrochmad, and Subagus Wahyuono. "Identification Bioactive Compound of Ethanol-Water Fraction of Coleus atropurpureus for Anti-rheumatic Rheumatism in CFA-induced Rats." Journal of Pharmaceutical Sciences and Community 19, no. 2 (November 30, 2022): 93–102. http://dx.doi.org/10.24071/jpsc.004746.
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Nonsteroidal anti-inflammatory drugs are used for pain and to slow the progression of rheumatoid arthritis. Accordingly, the discovery of rheumatoid arthritis active compounds from the ethanol-water fraction Coleus atropurpureus (EWC) was conducted to characterize the isolated compounds as well as the anti-rheumatic effects of the EWC induced Complete Freund's Adjuvant (CFA). We conducted in vivo study in rats which were randomly divided into 5 groups. Group 1 was only given CFA as a negative control. Group 2 as positive control was orally exposed to diclofenac potassium (9 mg/BW). Three groups were given different EWCs orally as follows: 11.25 mg/BW, 22.5 mg/BW, and 45 mg/BW, respectively. Rheumatism rates were then compared with positive controls using a visual arthritic scoring system. The compounds identified by isolation of the EWC of Coleus atropurpureus predicted forskolin. The ethanol-water fraction Coleus atropurpureus did not act as an anti-rheumatic arthritis agent in CFA-induced rats.
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Pehlivan, Yavuz, İbrahim Halil Türkbeyler, Özhan Uygun, Gazi Çömez, and Ahmet Mesut Onat. "Septic Arthritis Case Presented with Oligoarthritis in a Rheumatoid Arthritis." European Journal of Therapeutics 16, no. 3 (May 1, 2010): 31–33. http://dx.doi.org/10.58600/eurjther.2010-16-3-1222-arch.
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Rheumatoid arthritis is a chronic, systemic autoimmune disease that can affect many joints simultaneously and whose etiology is unknown. Septic arthritis is suppurative inflammation caused frequently by bacteria and rarely by mycetes. In the event that diagnosis is late and treatment is inadequate, it can cause joint and bone damage that can affect a person for lifetime. For this reason, it should be always considered as an emergency. Septic arthritis is commonly notified in rheumatoid arthritis patients. In this presentation a case that is followed with rheumatois arthritis diagnosis for 2 years and having septic arthritis in oligoarthritis etiology developed during the treatment is presented.
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Chang, Jia-Ming, Chun-Ming Cheng, Le-Mei Hung, Yuh-Shan Chung, and Rey-Yuh Wu. "Potential Use ofPlectranthus amboinicusin the Treatment of Rheumatoid Arthritis." Evidence-Based Complementary and Alternative Medicine 7, no. 1 (2010): 115–20. http://dx.doi.org/10.1093/ecam/nem168.
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Plectranthus amboinicus(P. amboinicus) is a folk herb that is used to treat inflammatory diseases or swelling symptoms in Taiwan. We investigated therapeutic efficacy ofP. amboinicusin treating Rheumatoid Arthritis (RA) using collagen-induced arthritis animal model. Arthritis was induced in Lewis rats by immunization with bovine type II collagen. Serum anti-collagen IgG, IgM and C-reactive protein (CRP) were analyzed. To understand the inflammation condition of treated animals, production of TNF-α, IL-6 and IL-1β from peritoneal exudates cells (PEC) were also analyzed.P. amboinicussignificantly inhibited the footpad swelling and arthritic symptoms in collagen-induced arthritic rats, while the serum anti-collagen IgM and CRP levels were consistently decreased. The production of pro-inflammatory cytokines TNF-α, IL-6 and IL-1β were also decreased in the high dosage ofP. amboinicusgroup. Here, we demonstrate the potential anti-arthritic effect ofP. amboinicusfor treating RA, which might confer its anti-rheumatic activity. This differs the pharmacological action mode of indomethacin.
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Mella, Lucas Francisco Botequio, Manoel Barros Bértolo, and Paulo Dalgalarrondo. "Depressive symptoms in rheumatoid arthritis." Revista Brasileira de Psiquiatria 32, no. 3 (August 13, 2010): 257–63. http://dx.doi.org/10.1590/s1516-44462010005000021.
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OBJECTIVE: To determine the prevalence of depressive and anxiety symptoms in patients with rheumatoid arthritis (a chronic inflammatory disease) in comparison to a control group with osteoarthritis (a chronic non-inflammatory degenerative disease) and to identify the sociodemographic and clinical variables associated with depressive symptoms in these patients. METHOD: Sixty-two rheumatoid arthritis patients and 60 osteoarthritis patients participated in the study. Sociodemographic and clinical data were collected and the Hospital Anxiety and Depression Scale and the Disability Index of the Health Assessment Questionnaire were applied. RESULTS: The prevalence of depressive symptoms was of 53.2% in rheumatoid arthritis and 28.3% in osteoarthritis (p = 0.005). The prevalence of anxiety symptoms was of 48.4% in rheumatoid arthritis and 50.0% in osteoarthritis (p = 0.859). The mean (and standard deviation) scores in the Disability Index of the Health Assessment Questionnaire were 1.4 (0.8) in rheumatoid arthritis and 1.4 (0.6) in osteoarthritis (p = 0.864). Rheumatoid arthritis patients with depressive symptoms had lower education and higher disease activity and functional disability. CONCLUSION: Although these two rheumatic diseases are similar in terms of the pain and functional disability that they cause, a significantly higher prevalence of depressive symptoms was found in rheumatoid arthritis patients. This difference might be explained by the hypothesis of a neuroimmunobiological mechanism related to cytokines in inflammatory diseases, which has been considered as a candidate to the development of depressive symptoms.
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Sahu, Lukeshwari, S. Prakash Rao, Mahendra Verma, Akhilesh Kumar, Rajendra Sahu, Dhanesh Kumar, and Chandrakant Yadav. "Cell Biology in Rheumatoid Arthritis." Journal of Drug Delivery and Therapeutics 10, no. 3-s (June 15, 2020): 348–57. http://dx.doi.org/10.22270/jddt.v10i3-s.4113.
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Rheumatoid arthritis (RA) is a systemic autoimmune disease, which affects about 0.33 to 2.65% of the population. In RA Synovium contain various type of immune cell. In which only one cell population cannot cause rheumatoid arthritis that requires more than one cell population. In normal condition, they act as a switch (active or inactive the cell signaling). It controls cell growth, proliferation or metastasizes. In an autoimmune disorder such as rheumatoid arthritis, the immune system mistakenly attacks and destroys the body's cells and tissues. Mostly cells are present in limited numbers in normal human synovium, but in rheumatoid arthritis and other inflammatory joint diseases, this population can expand to constitute 5-20% or more of all synovial cells. Recent investigations in a murine model have demonstrated that cells can have a critical role in the generation of inflammation within the joint.
Keyword: Cell Biology in rheumatic arthritis; Dendrite cell; T-cell; Mast cell; Fibroblastic cell; Macrophages cell.
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Greenblatt, H. Karl, Hyoun-Ah Kim, Leah F. Bettner, and Kevin D. Deane. "Preclinical rheumatoid arthritis and rheumatoid arthritis prevention." Current Opinion in Rheumatology 32, no. 3 (May 2020): 289–96. http://dx.doi.org/10.1097/bor.0000000000000708.
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Tarigan, Sri Wahyuni, Jumadiah Wardati Br Saragih, and Meyana Marbun. "Factors That Influence the Occurring of Rematoid Atritis (RA) in the Elderly in the Region of Puskesmas Raya Pematang Siantar 2021." Science Midwifery 9, no. 2 (April 10, 2021): 561–66. http://dx.doi.org/10.35335/midwifery.v9i2.744.
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This type of research is cross sectional, this study aims to determine the factors that influence the occurrence of rheumatoid arthritis in the elderly at Pematangsiantar Public Health Center. The subjects of this study were the elderly with a sample of 99 respondents. Data collection tools are questionnaires to answer questions and observation sheets. Rheumatoid arthritis is a disorder in the form of stiffness, swelling, pain and redness in the joints and surrounding tissues. Joint sufferers around the world have reached the number, especially in Indonesia, rheumatoid arthritis reaches 23.6% to 31.3%. This figure shows that the incidence of rheumatoid arthritis is high. There are several factors that influence the occurrence of rheumatoid arthritis in the elderly, namely, genetics, obesity, food and activity/work. This genetic factor influences the occurrence of rheumatoid arthritis in the elderly at Pematangsiantar Public Health Center. The highest frequency which has the highest genetic factor is 12 respondents (12.1%) and the lowest frequency is 87 respondents (87.9%). Obesity factors affect the occurrence of rheumatoid arthritis in the elderly at Pematangsiantar Public Health Center 29 respondents (29%) and the lowest is 70 respondents (70.0%) but affects the incidence of rheumatic arthritis in the elderly. Food factors that influence the occurrence of rheumatoid arthritis have the highest frequency with 86 respondents (86.3%) and the lowest frequency is 13 respondents (13.1%). Activity/occupation factors influence the occurrence of rheumatoid arthritis in the elderly with the highest frequency 76 respondents (76.8%) and the lowest 23 respondents (23 respondents)
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Gouze, Jean-Noel, Steven C. Ghivizzani, Elvire Gouze, Glyn D. Palmer, Oliver B. Betz, Paul D. Robbins, Christopher H. Evans, and James H. Herndon. "GENE THERAPY FOR RHEUMATOID ARTHRITIS." Hand Surgery 06, no. 02 (December 2001): 211–19. http://dx.doi.org/10.1142/s0218810401000709.
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Advances in understanding the biology of rheumatoid arthritis (RA) have opened new therapeutic avenues. One of these, gene therapy, involves the delivery to patients of genes encoding anti-arthritic proteins. This approach has shown efficacy in animal models of RA, and the first human, phase I trial has just been successfully completed. Hand surgery featured prominently in this pioneering study, as a potentially anti-arthritic gene encoding the interleukin-1 receptor antagonist was transferred to the metacarpophalangeal joints of subjects with RA one week before total joint arthroplasty. This study has confirmed that it is possible to transfer genes safely to human joints. It should pave the way for additional application of gene therapy to arthritis and other orthopaedic conditions.
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Ashiq, Kanwal, Sana Ashiq, Naureen Shehzadi, Khalid Hussain, and Muhammad Tanveer Khan. "PREVALENCE AND CONTROL OF THE HYPERTENSION IN PATIENTS SUFFERING FROM RHEUMATOID ARTHRITIS." Pakistan Heart Journal 55, no. 4 (December 31, 2022): 421–22. http://dx.doi.org/10.47144/phj.v55i4.2352.
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Hypertension or high blood pressure (BP) is a long-term ailment in which blood pressure in the arteries raises persistently. Blood pressure can be determined using two methods, systolic pressure which is the uppermost pressure and diastolic pressure which is the lowermost blood pressure in the arterial system. It is estimated that worldwide around 1.13 billion persons are suffering from hypertension. In addition, the World Health Organization (WHO) has reported that 13% of all deaths in the world are caused by hypertension. Furthermore, they set a target to reduce its frequency by 25% from the year 2010 to 2025.1,2 Rheumatoid arthritis (RA) is a systemic autoimmune disease that leads to inflammation of the joints and pain. Approximately 1% of the global population is diagnosed with this disease. Rheumatoid arthritis can be associated with multiple comorbidities that can reduce a patient's quality of life (QoL), upturn the economic burden of the disease, and may increase the rate of mortality. Cardiovascular comorbidities are quite common in patients with rheumatoid arthritis. Cardiovascular comorbidity is estimated to be about 1.5 times more frequent in patients with rheumatoid arthritis than in healthy people. Many studies have suggested that of all cardiovascular disorders, hypertension is the most important and changeable risk factor in subjects suffering from rheumatoid arthritis. Based on a pool of 115,867 insurance claims, about 76% of rheumatoid arthritis patients in America were diagnosed with hypertension. These results are similar to studies conducted in Europe and Canada that have shown a higher incidence of hypertension in patients with rheumatoid arthritis compared to the normal group. It is unknown why patients with rheumatoid arthritis pose such a high risk for hypertension. Reduced physical activity, obesity, systemic inflammation, and medications used to treat rheumatoid arthritis can increase the risk of high blood pressure.3 Around 0.55% of the urban population in northern Pakistan suffers from rheumatoid arthritis, while the incidence rate is close to 0.14% in southern Pakistan.4 There are many reasons why people with rheumatoid arthritis have high blood pressure. Chronic inflammation in rheumatoid arthritis results in increased rigidity of arteries leading to increase systolic blood pressure. The first presumed link between low-grade systemic inflammation and hypertension has been identified in previous studies conducted on the general population. In rheumatoid arthritis, elevated levels of C-reactive protein (CRP) increase the likelihood of developing high blood pressure. Several mechanisms may be implicated in the development of hypertension with a high concentration of C-reactive protein. For example, nitric oxide synthesis may be reduced because of the increased concentration of the C-reactive protein that will cause vasoconstriction, platelet activation and thrombosis. Additionally, increased expression of the type 1 angiotensin receptor and stimulation of the plasminogen activator inhibitor-1 (PAI-1) may contribute to the progression of hypertension. Occasionally, restriction on exercise due to the fear of worsening disease condition is recommended (unwarranted) by healthcare professionals, and it could be a reason for the inactive and sedentary lifestyle of patients with rheumatoid arthritis. In turn, physical idleness can lead to obesity, which may be linked independently to high blood pressure in rheumatoid arthritis. Obesity and familial history of hypertension are significant predictors of premature death. A study has also demonstrated that an increase in sodium (Na) intake and a decrease in potassium (K) intake can play a significant role in the pathogenesis of rheumatoid arthritis and high blood pressure. The urinary Na/K quotient may be useful as an important parameter of hypertension in patients suffering from rheumatoid arthritis and in normal subjects. Optimal cardiovascular risk management continues to be a major challenge. In this regard, increased awareness and management are needed to reduce the high risk of cardiovascular disorders in patients with rheumatoid arthritis. To date, only a few studies have investigated the potential relationship between high blood pressure and these factors in patients with rheumatoid arthritis. A lifestyle shift (i.e. exercise, smoking cessation, eating a balanced diet, reducing the use of ethanol and salt) is needed in patients suffering from rheumatoid arthritis to manage their high blood pressure and improve their quality of life (QoL). To treat rheumatoid arthritis, many medications are routinely prescribed, including cyclooxygenase, non-steroidal anti-inflammatory drugs (NSAIDs), steroids, and disease-modifying anti-rheumatic drugs (DMARDs). The use of these drugs in rheumatoid arthritis should always be considered in conjunction with comorbid hypertension. Clinicians should closely monitor such patients for prior diagnosis and, where appropriate, aggressive management of hypertension. Systems for diagnosis, proper treatment, and continuous surveillance of these patients need to be in place in primary and secondary healthcare setups. Furthermore, specially designed clinical trials are required to determine the finest approaches to treat hypertension in patients of rheumatoid arthritis.5-8 References Baharvand-Ahmadi B, Bahmani M, Tajeddini P, Rafieian-Kopaei M, Naghdi N. An ethnobotanical study of medicinal plants administered for the treatment of hypertension. J Ren Inj Prev. 2016;5(3):123. Ashiq K, Ashiq S, Shehzadi N. Hyperuricemia and its association with hypertension: risk factors and management. Pak Heart J. 2022;55(2):200-1. Hadwen B, Stranges S, Barra L. Risk factors for hypertension in rheumatoid arthritis patients–A systematic review. Autoimmun Rev. 2021;20(4):102786. Ehsan A, Mushtaq S, Salim B, Samreen S, Gul H, Nasim A. Translation and validation of Modified Health Assessment Questionnaire score in local language Urdu in patients with rheumatoid arthritis presenting in a tertiary care center of Pakistan. J Pak Med Assoc. 2022;72(4):674-8. Panoulas VF, Douglas KM, Milionis HJ, Stavropoulos-Kalinglou A, Nightingale P, Kita MD, et al. Prevalence and associations of hypertension and its control in patients with rheumatoid arthritis. Rheumatol. 2007;46(9):1477-82. Panoulas VF, Metsios GS, Pace A, John H, Treharne G, Banks M, et al. Hypertension in rheumatoid arthritis. Rheumatol. 2008;47(9):1286-98. Minamino H, Katsushima M, Hashimoto M, Fujita Y, Yoshida T, Ikeda K, et al. Urinary sodium-to-potassium ratio associates with hypertension and current disease activity in patients with rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther. 2021;23(1):1-10. Ashiq K, Ashiq S. COVID-19 pandemic and management of hypertension. Pak Heart J. 2021;54(3):275-6.
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Plakhova, A. O., V. N. Sorotskaya, and R. M. Balabanova. "The frequency of Helicobacter pylori infection in patients with rheumatoid arthritis and adult residents of the city of Tula." Rheumatology Science and Practice 60, no. 4 (September 7, 2022): 481–86. http://dx.doi.org/10.47360/1995-4484-2022-481-486.
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Currently, the list of microorganisms that have a possible connection with the development of rheumatoid arthritis continues to be updated. The role of not only traditional pathogens, but also representatives of conditionally pathogenic microflora is being actively studied. A number of domestic and foreign works demonstrate a high degree of Helicobacter pylori infection in patients with rheumatic diseases, including rheumatoid arthritis.The aim of the present study is to identify the frequency of detection of Helicobacter pylori infection in patients with rheumatoid arthritis and in adult residents of the city of Tula.Material and methods. The study included 3288 residents of Tula who do not have rheumatic diseases, and 119 patients with rheumatoid arthritis. To detect the infection, FEGDS was performed according to the generally accepted method with the taking of biopsies of the mucous membrane of the antrum and the stomach body, followed by verification of Helicobacter pylori using the Helpil-test test system.Results. According to the results of the data on the infection rate of residents of Tula without rheumatic diseases (n=3288), the largest percentage of infected (78.8%) was detected by an invasive method – express diagnosis of urease activity of the biopsy. The detection rate using a respiratory ammonia test and serological method was lower and amounted to 51.1 and 49.3%, respectively. In total, H. pylori was detected in 1692 people, which was 51.46%. Among patients with rheumatoid arthritis, Helicobacter pylori infection was 81.5%. Signs of damage to the mucous membrane of the upper gastrointestinal tract were often detected: superficial and subatrophic gastritis, single erosions.Conclusions. 1. Based on the study, it was found that the infection rate of Helicobacter pylori in patients with rheumatoid arthritis is at a fairly high level, not significantly different from that in residents without rheumatic diseases, when examined by an invasive method – express diagnosis of urease activity of the biopsy (81.5% and 78.8%, respectively). 2. Among patients with rheumatoid arthritis, there was a tendency to increase the frequency of infection with age and peak values in older age groups (r=0.37; p<0.05). 3. The frequency of detection of erosive and ulcerative lesions of the gastrointestinal tract in infected and uninfected Helicobacter pylori patients with rheumatoid arthritis significantly differed (42.2 and 13.6%) (p=0.03). Key words: Tula population, rheumatoid arthritis, Helicobacter pylori infection>˂ 0.05). 3. The frequency of detection of erosive and ulcerative lesions of the gastrointestinal tract in infected and uninfected Helicobacter pylori patients with rheumatoid arthritis significantly differed (42.2 and 13.6%) (p=0.03).
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Al-Rubaye, Mahmood R. "Anti-neutrophlic cytoplasmic antibody Elastase, Lactoferrin, Cathapsin G,and Lysozyme in a sample of Iraqi patients with Rheumatoid Arthritis." Journal of the Faculty of Medicine Baghdad 57, no. 1 (April 1, 2015): 68–74. http://dx.doi.org/10.32007/jfacmedbagdad.571312.
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mucosal secretions as well as in secondary granules of polymorphonuclear leukocytes. Anti-Elastase antibodies, anti-Lactoferrin antibodies,anti-Cathapsin G antibodies and anti-Lysozyme antibodies, which belong to Perinuclear Anti-Neutrophil Cytoplasmic Antibodies(pANCA) have been described in several immunomediated diseases, including Rheumatoid Arthritis .Objectives: Investigate the prevalence of anti-Elastase antibodies, anti-Lactoferrin antibodies,anti-Cathapsin G antibodies , anti- Lysozyme antibodies and rheumatoid factor in patients with rheumatoid arthritis in comparison to healthy control.Patients &Methods: The study involved 40 Rheumatoid Arthritis patients who were referred to Immunological Department in Teaching laboratory \ Medical City during period of (1st of January – 31st of June) 2011 and 25 apparently healthy individual used as a control group were investeged to rheumatic factor IgG, IgM ,IgA isotypes and Elastase antibodies, Lactoferrin antibodies, Cathapsin G antibodies , and lysozyme antibodies were measured by using enzyme immunoassay technique.Results : Anti- Elastase, Abs anti-Cathapsin G Abs ,and anti-lysozyme Abs showed significant correlation with RF screen, and the mean concentration for these antibodies in rheumatoid arthritis patients with significant difference if compare it with the healthy control group. While anti-Lactoferrin Abs showed no significant correlation with RF screen. This study showed a association between the positive results of anti- Cathapsin G Abs with RF IgG and RF IgM only .Anti- Elastase Abs, Anti-Lactoferrin Abs and Antilysozyme Abs showed neither a significant correlation with RF IgG, RF IgM nor with RF IgA.Conclusion:A significant correlation was found between Elastase antibodies, Cathapsin G antibodies , lysozyme antibodies and patients with rheumatiod arthritis Cathapsin G antibodies has a significant association with RF IgG and RF IgM
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Muliyani, Muliyani, Nazhipah Isnani, and Enny Fauziah. "GAMBARAN KARAKTERISTIK RESPONDEN RHEUMATOID ARTHRITIS PRE TREATMENT GINGER OIL (Zingiber Officinale Rosc) DAN TERAPI RESISTED ACTIVE MOVEMENT." Jurnal Insan Farmasi Indonesia 3, no. 2 (December 28, 2020): 337–43. http://dx.doi.org/10.36387/jifi.v3i2.589.
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Rheumatoid arthritis (RA) is the most common autoimmune inflammatory arthritis in adults. Pharmacological treatment is quite effective to overcome it, but in some cases, especially in elderly RA sufferers, pharmacological treatment such as non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids and DMARD (Disease Modifying Antirheumatic Drugs) have an impact on drug side effects, namely gastrointestinal disorders that cause toxic effects on liver and kidney. The developed natural medicine treatment has been supported by several previous studies that provide anti-inflammatory benefits, namely, ginger (Zingiber Officinale Rosc.). Ginger (Zingiber Officinale Rosc.) The method used is descriptive. The purpose of this study was to determine the characteristics of respondents who suffer from rheumathoid arthritic therapy with essential ginger oil and resisted active movement. The results of the study showed that as many as 20 respondents who suffered from rheumatoid arthritis, based on their characteristics, the most were female, namely 16 people (80%, ages 60-75 years, as many as 15 people (75%), the most part of the joints experiencing rheumathoid arthritis. occurred in the knee as many as 9 people (45%), work history, at most not working as many as 8 people (40%), history of injury, there were most injuries as many as 12 people (60%)
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Бестаев, D. Bestaev, Божьева, and L. Bozheva. "Clinical, laboratory and instrumental characteristics in patients with rheumatoid arthritis with "ground glass opacity" computed tomographic symptom of interstitial lung disease." Journal of New Medical Technologies. eJournal 9, no. 1 (April 17, 2015): 0. http://dx.doi.org/10.12737/10474.
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Rheumatoid arthritis is an inflammatory rheumatic disease with unknown etiology characterized by symmetric, chronic and erosive arthritis (synovitis) of the peripheral joints and systemic inflammatory involvement of the viscera. Lung pathology, including interstitial lung disease, is one of the common extra-articular manifestations at the гheumatoid arthritis. The leading diagnosis method of interstitial lung disease is a computed tomography high resolution, which allows to identifying interstitial lung changes in 70% of the cases. The study of prognosis in patients with rheumatoid arthritis interstitial lung disease has been the subject of several studies in the past decade. In most studies it was stated that the average life expectancy from diagnosis is around 3 years. This work is devoted to study of interstitial lung disease as one of the most frequent extra-articular ma-nifestations of rheumatoid arthritis. The authors defined the significance of computed tomography high resolu-tion for the diagnosis of pulmonary interstitial lung changes at rheumatoid arthritis. They give comparative clini-cal and immunological, instrumental characteristics of rheumatoid arthritis patients with interstitial lung disease and without it. The role of smoking and positivity of anti-cyclic citrullinated peptide (anti-CCP) according to antibodies are determined as risk factors of interstitial lung disease development in patients with rheumatoid arthritis. The interrelation of the X-ray tomography symptom of interstitial lung disease "ground glass opacity" with the activity and duration of rheumatoid arthritis is revealed. "Ground glass opacity" symptom is associated with high index of DAS28 in patients with rheumatoid arthritis with interstitial lung disease.
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Curyło, Mateusz, Marlena Rynkiewicz-Andryśkiewicz, Agnieszka Ciukszo, Damian Szubski, Ewa Kucharska, Jan Czernicki, and Jan W. Raczkowski. "Rheumatoid arthritis and rheumatoid foot in physiotherapy." Fizjoterapia Polska 21, no. 2 (June 30, 2021): 172–83. http://dx.doi.org/10.56984/8zg0dd753.
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Rheumatic diseases are not fatal, but they result in shorter life expectancy of the patients suffering from them. This applies to all inflammatory rheumatic diseases, especially rheumatoid arthritis (RA). Rheumatic diseases, in which most of all the joint inflammatory process develops with progressive joint damage, are the cause of patients’ disability, prevent patients from working and everyday functioning, also at home, and affect all aspects of social life. The objective of rehabilitation in RA is to relieve pain, reduce or inhibit inflammation, and maintain the proper functioning of the locomotor system while slowing down or ceasing structural lesions in the joints.
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Lafyatis, R., N. L. Thompson, E. F. Remmers, K. C. Flanders, N. S. Roche, S. J. Kim, J. P. Case, M. B. Sporn, A. B. Roberts, and R. L. Wilder. "Transforming growth factor-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats. Studies on secretion by synovial fibroblast-like cells and immunohistologic localization." Journal of Immunology 143, no. 4 (August 15, 1989): 1142–48. http://dx.doi.org/10.4049/jimmunol.143.4.1142.
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Abstract The growth of synovial fibroblast-like cells from patients with rheumatoid arthritis and rats with streptococcal cell wall (SCW)-induced arthritis in vitro under anchorage-independent conditions is inhibited by transforming growth factor-beta (TGF-beta). Because this growth factor is present in rheumatoid synovial fluids, we studied whether this cytokine might be secreted by cells in rheumatoid synovial tissue. We show that synovial tissues from patients with rheumatoid arthritis and osteoarthritis, and rats with SCW-induced arthritis, contain TGF-beta-1 mRNA. TGF-beta, predominantly type 1, was spontaneously secreted in vitro by synovial tissue explants and synovial fibroblast-like cells. In addition, TGF-beta could be detected immunohistochemically in cells throughout rheumatoid and SCW-induced arthritic rat synovial tissues. Finally, exogenous TGF-beta induced collagen and inhibited collagenase mRNA levels by cultured synoviocytes. These data support an autocrine role for TGF-beta in the regulation of synoviocytes in rheumatoid arthritis and, in light of its demonstrated effects on the immune system, suggest that TGF-beta might also have important paracrine effects on infiltrating inflammatory cells.
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Puri, Kamal D., Bart H. Steiner, Adam S. Kashishian, Hao Chen, W. Michael Gallatin, and Neill A. Giese. "IC87114, a Selective Inhibitor of PI3Kδ Suppresses Joint Inflammation and Bone Erosion in Collagen-Induced Arthritis in Rat (50.14)." Journal of Immunology 182, no. 1_Supplement (April 1, 2009): 50.14. http://dx.doi.org/10.4049/jimmunol.182.supp.50.14.
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Abstract PI3Kδ plays an essential role in antigen-receptor signaling, proliferation, activation and function of lymphocytes. Mice deficient in PI3Kδ activity show substantial reduction in immunoglobulin levels, partial impairment in chemoattractant-induced neutrophil migration as well as defects in signaling and function of macrophages. Collagen-induced arthritis (CIA), a commonly used model for studying antirheumatic drugs, requires participation of both B and T cells to initiate disease and reproduces many of the pathogenic mechanisms detected in human rheumatoid arthritis. In this study, we have investigated the ability of IC87114, a selective PI3Kδ inhibitor, to reverse the rheumatoid arthritic like state in the CIA model of arthritis. Clinical arthritis was initiated by immunizing animals with collagen followed by a booster dose on day 7. IC87114 or control treatment was initiated when at least one hind paw was significantly inflamed and continued for an 18-day treatment course. IC87114-treatment of arthritic rats reduced the progression and severity of clinical arthritis that was evident within 6 days after initiation of therapy. IC87114-treatment significantly reduced the level of anti-collagen antibodies. Arthritic rats treated with IC87114 had significantly lower radiographic scores compared with control, indicating that treatment with IC87114 was effective in protecting bone integrity. Histopathological evaluation demonstrated that IC87114 was effective in reducing the histological changes induced by rheumatoid arthritis. The effect of IC87114-treatment on these parameters together suggests a therapeutic potential for PI3Kδ-selective compounds to ameliorate rheumatoid arthritis.
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Berardi, S., A. Corrado, N. Maruotti, D. Cici, and F. P. Cantatore. "Osteoblast role in the pathogenesis of rheumatoid arthritis." Molecular Biology Reports 48, no. 3 (March 2021): 2843–52. http://dx.doi.org/10.1007/s11033-021-06288-y.
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AbstractIn the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritis, osteoarthritis, osteoporosis, alterations in osteoblast growth, differentiation and activity play a role. In particular, in rheumatoid arthritis bone homeostasis is perturbed: in addition to stimulating the pathologic bone resorption process performed by osteoclasts in course of rheumatoid arthritis, proinflammatory cytokines (such as Tumor Necrosis factor-α, Interleukin-1) can also inhibit osteoblast differentiation and function, resulting in net bone loss. Mouse models of rheumatoid arthritis showed that complete resolution of inflammation (with maximal reduction in the expression of pro-inflammatory factors) is crucial for bone healing, performed by osteoblasts activity. In fact, abnormal activity of factors and systems involved in osteoblast function in these patients has been described. A better understanding of the pathogenic mechanisms involved in osteoblast dysregulation could contribute to explain the generalized and focal articular bone loss found in rheumatoid arthritis. Nevertheless, these aspects have not been frequently and directly evaluated in studies. This review article is focused on analysis of the current knowledge about the role of osteoblast dysregulation occurring in rheumatoid arthritis: a better knowledge of these mechanisms could contribute to the realization of new therapeutic strategies.
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Teaha, Diana Ioana Manuela, Nicoleta Anamaria Pascalau, Florin Mihai Marcu, and Liviu Lazar. "Comparative Study on the Extent of Damage to Life Quality in Rheumatoid Arthritis Patients with Different Therapeutic Strategies." Revista de Chimie 70, no. 8 (September 15, 2019): 2908–11. http://dx.doi.org/10.37358/rc.19.8.7454.
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Rheumathoid Arthritis affects more that 17.6 million of people worldwide [1]. Along with the diagnosis of Rheumatoid Arthrits (RA) comes a big change in patients life. The aim of this study was to evaluate the impact of disease stage or evolution on the patients quality of life, comparing 4 different therapeutic strategies, pursuing HAQ score and VAS (visual analogue pain scale).
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Acar, M., E. Tonga, A. Daskapan, M. Karataş, and A. Tekindal. "Comparison of Physical Activity Levels in Rheumatic Diseases." Aktuelle Rheumatologie 42, no. 04 (June 29, 2016): 329–35. http://dx.doi.org/10.1055/s-0042-100614.
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Abstract Objectives: The aim of this study was to evaluate levels of physical activity in patients with rheumatoid arthritis, osteoarthritis and fibromyalgia and to compare the results with both healthy subjects and each other. Methods: A group of 50 rheumatoid arthritis patients, 95 osteoarthritis patients, 82 fibromyalgia patients and 110 healthy subjects were included in this study. Physical activity levels were assessed by the International Physical Activity Questionnaire (IPAQ). Results: There were significant differences in walking and total physical activity scores in IPAQ between the rheumatoid arthritis (RA), osteoarthritis (OA), fibromyalgia (FMS) patients and the control group (p<0.05). 36.6% of the fibromyalgia group, 28.4% of the osteoarthritis group, 38% of the rheumatoid arthritis group and 22.7% of the healthy subjects were found to be inactive. 45.1% of the fibromyalgia group, 42.1% of the osteoarthritis group, 46% of the rheumatoid arthritis group and 36.4% of the healthy subjects were found to be insufficiently active. Conclusion: As a result, when compared to healthy people, physical activity levels were significantly decreased in patients with rheumatoid arthritis, osteoarthritis, fibromyalgia. The decreases in the physical activity levels were clearer in patients with rheumatoid arthritis than in patients with osteoarthritis and fibromyalgia. Recommending regular physical activity should be integral to rheumatic disease management and walking offers a potentially accessible, inexpensive, and acceptable physical activity intervention.
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Rajashekar Perusomula, Shruthi Thamannagari, Gayathri Paturi, and Ramesh Alluri. "Evaluation of anti-arthritic activity of Hyptis suaveolens seeds in rats." GSC Biological and Pharmaceutical Sciences 27, no. 3 (June 30, 2024): 077–98. http://dx.doi.org/10.30574/gscbps.2024.27.3.0225.
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Rheumatoid arthritis has been treated with Hyptis suaveolens (L) poit. seeds. There has been no pharmaceutical assessment for rheumatoid arthritis. A study aims to assess the anti-arthritic properties of aqueous extract of Hyptis suaveolens (L) poit… seeds (AEHS). Standard techniques were used for phytochemical analysis. Tested anti-arthritic potential in-vitro (25-800µg/ml egg albumin) and in vivo (200 and 400 mg/kg egg albumin induced arthritic model). Chemicals such alkaloids, sugars, flavonoids, phenols, and terpenoids were found. Results showed 75% reduction of protein denaturation at 800µg/ml in-vitro. According to the Egg albumin model, AEHS considerably (P < 0.0001) inhibits changes in paw volume, joint diameter, and body weight. It also improves hematological, biochemical, and histopathological levels. The findings confirm the traditional usage of Hyptis suaveolens(L)poit. seeds to treat rheumatoid arthritis.
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Baillet, Athan, Candice Trocmé, Xavier Romand, Chuong M. V. Nguyen, Anais Courtier, Bertrand Toussaint, Philippe Gaudin, and Olivier Epaulard. "Calprotectin discriminates septic arthritis from pseudogout and rheumatoid arthritis." Rheumatology 58, no. 9 (March 28, 2019): 1644–48. http://dx.doi.org/10.1093/rheumatology/kez098.
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Abstract Objective We aimed to determine whether calprotectin and α-defensins could discriminate septic from other inflammatory arthritides. Methods Synovial fluids with a predominance of neutrophils from patients with septic arthritis, pseudogout and RA were prospectively collected. Neutrophil-related proteins calprotectin and human neutrophil α-defensins levels were assessed in synovial fluids. Demographic parameters and biomarkers with P-value ⩽0.05 for differentiating septic from non-septic arthritis were included in a multivariable model. Multivariable logistic regression with stepwise selection was performed to build the final combined model. Results A total of 74 patients were included: septic arthritis (n = 26), pseudogout (n = 28) and RA (n = 20). Patients with septic arthritis were more likely to be male and young, and to display higher synovial neutrophil count. Calprotectin was significantly increased in patients with septic arthritis. The multivariable model included calprotectin, synovial fluid neutrophil count and gender. Calprotectin was the only biomarker that discriminated septic arthritis from non-septic inflammatory arthritides, with 76% sensitivity, 94% specificity and a positive likelihood ratio = 12.2 at the threshold for calprotectin of 150 mg/l. Conclusion Synovial fluid calprotectin is a relevant biomarker to discriminate septic arthritis from other inflammatory arthritides. This biomarker should be tested in an independent cohort.
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Gómez-SanMiguel, Ana Belén, Ana Isabel Martín, Maria Paz Nieto-Bona, Carmen Fernández-Galaz, María López-Menduiña, María Ángeles Villanúa, and Asunción López-Calderón. "Systemic α-melanocyte-stimulating hormone administration decreases arthritis-induced anorexia and muscle wasting." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 304, no. 10 (May 15, 2013): R877—R886. http://dx.doi.org/10.1152/ajpregu.00447.2012.
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Rheumatoid cachexia is associated with rheumatoid arthritis and it increases mortality and morbidity. Adjuvant-induced arthritis is an experimental model of rheumatoid arthritis that causes anorexia and muscle wasting. α-Melanocyte-stimulating hormone (α-MSH) has anti-inflammatory actions, and it is able to decrease inflammation in several inflammatory diseases including experimental arthritis. In this study we tested whether systemic α-MSH treatment is able to ameliorate cachexia in arthritic rats. On day 8 after adjuvant injection control and arthritic rats were treated with α-MSH (50 μg/rat ip) twice a day, until day 16 when all rats were euthanized. Arthritis decreased food intake, but it increased hypothalamic expression of neuropeptide Y (NPY) and Agouti-related peptides (AgRP) as well as interleukin-1β (IL-1β) and cyclooxygenase-2 (COX-2) mRNA. In arthritic rats, α-MSH decreased the external signs of arthritis and increased food intake ( P < 0.01). In addition, α-MSH decreased hypothalamic expression of IL-1β, COX-2, proopiomelanocortin, and prohormone-converting (PC) enzymes PC1/3 and PC2 mRNA in arthritic rats. In control rats, α-MSH did not modify food intake or hypothalamic expression of aforementioned mRNA. α-MSH prevented arthritis-induced increase in gastrocnemius COX-2, muscle-specific RING-finger protein-1 (MuRF1), and atrogin-1 expression, and it increased fast myofiber size. In conclusion our data show that in arthritic rats peripheral α-MSH treatment has an anti-cachectic action increasing food intake and decreasing muscle wasting.
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Feiskhanova, L. I., and D. I. Abdulganieva. "Early signs of myocardial dysfunction in patients with rheumatoid arthritis and ankylosing spondylitis." Clinician 14, no. 3-4 (January 26, 2021): 36–42. http://dx.doi.org/10.17650/1818-8338-2020-14-3-4-k632.
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The objective of the study – identify early preclinical signs of myocardial dysfunction in patients with rheumatoid arthritis and ankylosing spondylitis.Material and methods. We examined 142 people with verified rheumatic diseases. All patients were divided into 2 groups. The first group consisted of patients with rheumatoid arthritis – 95 people. The second group – patients with ankylosing spondylitis – 47 people. The control group included 70 practically healthy individuals. In addition to standard diagnostic tests, all patients underwent tissue dopplerography of the heart using the GE Vivid E9 ultrasound device using the two-dimensional deformation technique (speckle tracking) to assess the deformation and rate of myocardial deformation, as well as determining the level of matrix metalloproteinase-9 in the blood serum.Results. Among patients with rheumatoid arthritis, diastolic dysfunction of both the left ventricle and both ventricles was more common than in the control group. The same pattern was observed in the group with ankylosing spondylitis. The calculation of the relative risk showed that the presence of rheumatoid arthritis in 4,42 times increases the risk of diastolic dysfunction of the left ventricle in comparison with practically healthy people (CI 1,6–12,2). In individuals with rheumatoid arthritis also results in a deterioration of systolic function of both ventricles. The level of matrix metalloproteinase metalloproteinase-9 was highest and most often increased in patients with ankylosing spondylitis. Among patients with rheumatoid arthritis, the average level of metalloproteinase-9 was low, but the incidence was higher than in the control group. The obtained results indicate that in these rheumatic diseases there is a marked degradation of the extracellular matrix components.Conclusion. Patients with rheumatoid arthritis and ankylosing spondylitis are characterized by a deterioration in the diastolic function of the left ventricle or both ventricles simultaneously, which is accompanied by an increase in the level of metalloproteinase-9.
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Seidner, Pya. "Painful Rheumatoid Arthritis." Pain Physician 5;14, no. 5;9 (September 14, 2011): E427—E458. http://dx.doi.org/10.36076/ppj.2011/14/e427.
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Rheumatoid arthritis is a crippling disease that is often associated with severe pain, suffering, and diminished function, thereby detracting from an optimal quality of life. Over the past decade a greater appreciation of the pathophysiology of rheumatoid arthritis has been gained. In the past “decade of pain research,” biologic agents which may modify rheumatoid arthritis have emerged as potent therapeutic antirheumatic drugs. Biologic agents include 5 tumor necrosis factor alpha inhibitors (etanercept, infliximab, adalimumab, golimumab, certolizumab pegol), interleukin-1 blockers (anakinra), monocloncal antibodies against B cells (rituximab), T cell costimulation blocker (abatacept), and interleukin-6 inhibitors (tocilizumab). Currently, utilizing therapy aimed at targeting various abnormalities of rheumatoid arthritis may be possible. It appears that the combined use of etanercept and methotrexate may improve the imbalance of Th1/Th2 and Th17/regulatory T cells (Treg) (and related cytokines) often seen in rheumatoid arthritis. Furthermore, this improvement in Tcell ratios/cytokines is also associated with improvement in clinical indicators of rheumatoid arthritis severity. Although rheumatologists are generally the specialists “called on” to manage complex patients with rheumatoid arthritis, pain specialists may be asked to join interdisciplinary teams managing patients with advanced refractory rheumatoid arthritis with severe pain since one of the most common and debilitating symptoms of rheumatoid arthritis is pain. Thus, pain specialists should have some appreciation of the current thoughts regarding rheumatoid arthritis pathophysiology and treatment. This narrative review of rheumatoid arthritis is intended to familiarize the interventional pain specialist with current concepts surrounding rheumatoid arthritis. Key words: Rheumatoid Arthritis, Pain, DMARDs, biological agengs, TNF inhibitors
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Wasan Nazhan Hussein, Sayran Sattar Saleh, and Wissam Sbhan Khalf. "Determination of Homocysteine and Vitamin B12 level in blood Patients Rheumatoid Arthritis in KirKuk Governorate." Tikrit Journal of Pure Science 21, no. 5 (February 6, 2023): 104–9. http://dx.doi.org/10.25130/tjps.v21i5.1036.
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Many of the clinical studies have clearly demonstrated the direct link between the high levels of homocystien in serum and Rheumatoid Arthritis and homocystien shows its impact by imbalance self- oxidized when high concentration in blood, which leads to a group of deeply rooted Free radicals and Rheumatoid Arthritis RA of Disease Fades inflammatory caused by free roots which cause injury to the damage or the total deficit circumstantial there are some features may occur to the formation of a contract of rheumatic smal
Objective:. The aim of this study to assess the level of homocystien and vitamin B12patients suffering from Rheumatoid Arthritis compared with healthy people and operate in order relationship with vitamin B12 and its impact causing high levels of homocystien disease Rheumatoid Arthritis
The way:- collecting blood samples (25) people healthy people (Control) (15) of the males and 10 females aged from (25-65) and (50) people of the patients (25) of the males and (25) of the females aged from (25-65) and those suffering from Rheumatoid Arthritis and measurement of the level of homocystien and vitamin B12.
The findings and conclusions:- found that there is a moral rise in the level of homocystien when a group of patients suffering from Rheumatoid Arthritis compared with healthy group at the level of contingent liabilities (P≤0001) found moral decline in the level of vitamin B12 when a group of patients suffering from Rheumatoid Arthritis compared to a healthy and at the level of contingent liabilities (P≤0.0005).
Word: homocystien , vitamin B12 , Rheumatoid Arthritis
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Rennebohm, Robert M. "Rheumatic Diseases of Childhood." Pediatrics In Review 10, no. 6 (December 1, 1988): 183–90. http://dx.doi.org/10.1542/pir.10.6.183.
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The pediatrician frequently encounters children and adolescents with musculoskeletal complaints that raise the possibility of rheumatic disease. The purposes of this article are: to review an approach to the evaluation of "joint" symptoms and to review the pharmacology, use, and adverse effects of nonsteroidal anti-inflammatory drugs. RHEUMATOLOGIC HISTORY Systematic collection of the historical details is fundamental in the evaluation of "joint" complaints (Table 1). Age and Sex The child's age and sex provide initial clues. For example, suspicion that a young girl (less than 5 years of age) with knee swelling might have monoarticular juvenile rheumatoid arthritis is heightened simply because of her age and sex. (At onset of their disease, almost 20% of all patients with juvenile rheumatoid arthritis are young girls with pauciarthritis, most commonly involving the knee.) Suspicion that an older boy (10 years of age or older) with axioskeletal complaints might have an enthesopathy syndrome is increased, in part, because of his age and sex. of the age and sex predilections of various rheumatic conditions is, therefore, helpful. Chief Complaint The chief complaint is often directive. For example, the complaint "his knees hurt every night" or "his legs hurt at night" is not characteristic of children who have juvenile rheumatoid arthritis or other well-defined inflammatory arthritides.
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Gorbunova, Yu N., L. V. Kondratyeva, T. V. Popkova, N. V. Demin, A. V. Smirnov, and E. L. Nasonov. "Body composition in patients with early rheumatoid arthritis." Rheumatology Science and Practice 59, no. 1 (March 3, 2021): 70–74. http://dx.doi.org/10.47360/1995-4484-2021-70-74.
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Aim of the study was to clarify the body composition in patients with early rheumatoid arthritis before starting therapy with synthetic basic anti-inflammatory drugs, genetically engineered biological drugs and glucocorticoids using dual-energy X-ray absorptiometry and to assess the effect of inflammation and metabolic syndrome on body composition.Material and methods. The study included 37 patients (31 women and 6 men) with early rheumatoid arthritis. The control group consisted of 19 healthy donors without rheumatic diseases. Patients with rheumatoid arthritis and the control group were measured by waist size, height and weight, and body mass index was calculated. Body composition was determined by means of dual-energy X-ray absorptiometry using the “Whole Body” program on the HOLOGIC device (USA). The presence of metabolic syndrome was assessed according to the criteria of the International Diabetes Federation (IDF).Results. Patients with early rheumatoid arthritis had less lean tissue mass, which was negatively correlated with inflammatory markers (ESR and C-reactive protein levels). Overweight and obesity were diagnosed in 24% and 27% of patients with early rheumatoid arthritis, respectively. Patients with rheumatoid arthritis and metabolic syndrome had a higher body weight, body mass index, waist size, and adipose tissue mass than patients without metabolic syndrome. With the help of instrumental methods, it is shown that in rheumatoid arthritis there is a redistribution of fat mass in the body, its predominant accumulation in the trunk area and a parallel decrease in the volume of muscle tissue.Conclusion. Rheumatoid inflammation and metabolic syndrome affect body composition of patients with early rheumatoid arthritis before the start of antirheumatic therapy.
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Šenolt, Ladislav. "Rheumatoid arthritis." Vnitřní lékařství 64, no. 2 (February 1, 2018): 98–106. http://dx.doi.org/10.36290/vnl.2018.017.
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Cush, John J. "Rheumatoid Arthritis." Medical Clinics of North America 105, no. 2 (March 2021): 355–65. http://dx.doi.org/10.1016/j.mcna.2020.10.006.
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Ramsburg, Karen L. "Rheumatoid Arthritis." American Journal of Nursing 100, no. 11 (November 2000): 40. http://dx.doi.org/10.2307/3522259.
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Tugwell, Peter, Zulma Ortiz, and Bridget Griffiths. "Rheumatoid Arthritis." Disease Management & Health Outcomes 1, no. 3 (March 1997): 141–53. http://dx.doi.org/10.2165/00115677-199701030-00004.
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Leeb, Burkhard F., Katharina Weber, and Josef S. Smolen. "Rheumatoid Arthritis." Disease Management and Health Outcomes 4, no. 6 (1998): 315–24. http://dx.doi.org/10.2165/00115677-199804060-00002.
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Davis, John M. "Rheumatoid Arthritis." Mayo Clinic Proceedings 85, no. 8 (August 2010): e59. http://dx.doi.org/10.4065/mcp.2010.0227.
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