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Relevant bibliographies by topics / Retroviruses; Tax

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Academic literature on the topic 'Retroviruses; Tax'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Retroviruses; Tax"

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Lin, Jennifer, and Bryan R. Cullen. "Analysis of the Interaction of Primate Retroviruses with the Human RNA Interference Machinery." Journal of Virology 81, no. 22 (2007): 12218–26. http://dx.doi.org/10.1128/jvi.01390-07.

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ABSTRACT The question of whether retroviruses, including human immunodeficiency virus type 1 (HIV-1), interact with the cellular RNA interference machinery has been controversial. Here, we present data showing that neither HIV-1 nor human T-cell leukemia virus type 1 (HTLV-1) expresses significant levels of either small interfering RNAs or microRNAs in persistently infected T cells. We also demonstrate that the retroviral nuclear transcription factors HIV-1 Tat and HTLV-1 Tax, as well as the Tas transactivator encoded by primate foamy virus, fail to inhibit RNA interference in human cells. Mor

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Cleveland, Susan M., and Utpal P. Dave. "Insertional Activation of GLI2 in Adult T-Cell Leukemia/Lymphoma." Blood 110, no. 11 (2007): 4149. http://dx.doi.org/10.1182/blood.v110.11.4149.4149.

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Abstract Retroviruses induce cancer by integrating into the cellular genome and activating oncogenes or inactivating tumor suppressor genes. Human T-cell Leukemia Virus type 1 (HTLV-1), a complex retrovirus, induces Adult T-cell Leukemia/Lymphoma (ATLL) after a latency of over 30 years and in only 5% of carriers. The long latency and incomplete penetrance is similar to how slow transforming retroviruses induce cancer in mice and imply multiple oncogenic “hits” need to accumulate for clinically apparent disease. Insertional mutagenesis may be one mechanism by which ATLL develops. We used splink

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Lemasson, Isabelle, Nicholas J. Polakowski, Paul J. Laybourn, and Jennifer K. Nyborg. "Transcription Regulatory Complexes Bind the Human T-Cell Leukemia Virus 5′ and 3′ Long Terminal Repeats To Control Gene Expression." Molecular and Cellular Biology 24, no. 14 (2004): 6117–26. http://dx.doi.org/10.1128/mcb.24.14.6117-6126.2004.

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ABSTRACT The human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that integrates randomly into the T-cell genome. Two long terminal repeats (LTRs) flank the integrated provirus. The upstream and downstream LTRs carry identical promoter sequences. Studies with other retroviruses suggest that the downstream promoter is silent and that RNA polymerases initiating at the upstream promoter proceed through the 3′ LTR. In this study, we used the chromatin immunoprecipitation assay to compare the binding of transcription regulatory proteins at both the upstream and downstream promoters in HTLV-

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Ghosh, SK, JT Abrams, H. Terunuma, EC Vonderheid, and E. DeFreitas. "Human T-cell leukemia virus type I tax/rex DNA and RNA in cutaneous T- cell lymphoma." Blood 84, no. 8 (1994): 2663–71. http://dx.doi.org/10.1182/blood.v84.8.2663.2663.

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Abstract Peripheral blood mononuclear cells (PBMCs) and T-cell lines from patients with Sezary syndrome (SS) and skin lesions from patients with mycosis fungoides (MF) were examined by polymerase chain reaction (PCR) for DNA sequences homologous to the human retroviruses human T- lymphotropic virus (HTLV)-I and -II. Results obtained using primers and probes from the tax/rex region of HTLV-I indicate that 72% (18/25) of SS patients PBMCs, 80% (20/25) of T-cell lines established from SS- PBMC, and 30% (3/10) of skin lesions from MF patients were positive for HTLV-I tax/rex region DNA. Sequence a

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Ghosh, SK, JT Abrams, H. Terunuma, EC Vonderheid, and E. DeFreitas. "Human T-cell leukemia virus type I tax/rex DNA and RNA in cutaneous T- cell lymphoma." Blood 84, no. 8 (1994): 2663–71. http://dx.doi.org/10.1182/blood.v84.8.2663.bloodjournal8482663.

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Peripheral blood mononuclear cells (PBMCs) and T-cell lines from patients with Sezary syndrome (SS) and skin lesions from patients with mycosis fungoides (MF) were examined by polymerase chain reaction (PCR) for DNA sequences homologous to the human retroviruses human T- lymphotropic virus (HTLV)-I and -II. Results obtained using primers and probes from the tax/rex region of HTLV-I indicate that 72% (18/25) of SS patients PBMCs, 80% (20/25) of T-cell lines established from SS- PBMC, and 30% (3/10) of skin lesions from MF patients were positive for HTLV-I tax/rex region DNA. Sequence analysis o

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Younis, Ihab, Lyne Khair, Miroslav Dundr, Michael D. Lairmore, Genoveffa Franchini, and Patrick L. Green. "Repression of Human T-Cell Leukemia Virus Type 1 and Type 2 Replication by a Viral mRNA-Encoded Posttranscriptional Regulator." Journal of Virology 78, no. 20 (2004): 11077–83. http://dx.doi.org/10.1128/jvi.78.20.11077-11083.2004.

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ABSTRACT Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 are complex retroviruses that persist in the host, eventually causing leukemia and neurological disease in a small percentage of infected individuals. In addition to structural and enzymatic proteins, HTLV encodes regulatory (Tax and Rex) and accessory (open reading frame I and II) proteins. The viral Tax and Rex proteins positively regulate virus production. Tax activates viral and cellular transcription to promote T-cell growth and, ultimately, malignant transformation. Rex acts posttranscriptionally to facilitate cytoplasmic ex

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Endo, Keiichi, Akira Hirata, Kousuke Iwai, et al. "Human T-Cell Leukemia Virus Type 2 (HTLV-2) Tax Protein Transforms a Rat Fibroblast Cell Line but Less Efficiently than HTLV-1 Tax." Journal of Virology 76, no. 6 (2002): 2648–53. http://dx.doi.org/10.1128/jvi.76.6.2648-2653.2002.

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ABSTRACT Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 are retroviruses with similar biological properties. Whereas HTLV-1 is the causative agent of an aggressive T-cell leukemia, HTLV-2 has been associated with only a few cases of lymphoproliferative disorders. Tax1 and Tax2 are the transcriptional activators of HTLV-1 and HTLV-2, respectively. Here we show that Tax2 transformed a Rat-1 fibroblast cell line to form colonies in soft agar, but the size and number of the colonies were lower than those of Tax1. Use of a chimeric Tax protein showed that the C-terminal amino acids 300 to 3

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Kucerova, Lucia, Veronika Altanerova, Cestmir Altaner, and Kathleen Boris-Lawrie. "Bovine Leukemia Virus Structural Gene Vectors Are Immunogenic and Lack Pathogenicity in a Rabbit Model." Journal of Virology 73, no. 10 (1999): 8160–66. http://dx.doi.org/10.1128/jvi.73.10.8160-8166.1999.

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ABSTRACT Infection with a replication-competent bovine leukemia virus structural gene vector (BLV SGV) is an innovative vaccination approach to prevent disease by complex retroviruses. Previously we developed BLV SGV that constitutively expresses BLV gag, pol, and env and related cis-acting sequences but lacks tax, rex, RIII, andGIV and most of the BLV long terminal repeat sequences, including the cis-acting Tax and Rex response elements. The novel SGV virus is replication competent and replicates a selectable vector to a titer similar to that of the parental BLV in cell culture. The overall g

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Arnold, Joshua, Brenda Yamamoto, Min Li, et al. "Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1." Blood 107, no. 10 (2006): 3976–82. http://dx.doi.org/10.1182/blood-2005-11-4551.

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Natural antisense viral transcripts have been recognized in retroviruses, including human T-cell leukemia virus type 1 (HTLV-1), HIV-1, and feline immunodeficiency virus (FIV), and have been postulated to encode proteins important for the infection cycle and/or pathogenesis of the virus. The antisense strand of the HTLV-1 genome encodes HBZ, a novel nuclear basic region leucine zipper (b-ZIP) protein that in overexpression assays down-regulates Tax oncoprotein-induced viral transcription. Herein, we investigated the contribution of HBZ to HTLV-1–mediated immortalization of primary T lymphocyte

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Goldberg, Tony L., David M. Sintasath, Colin A. Chapman, et al. "Coinfection of Ugandan Red Colobus (Procolobus [Piliocolobus] rufomitratus tephrosceles) with Novel, Divergent Delta-, Lenti-, and Spumaretroviruses." Journal of Virology 83, no. 21 (2009): 11318–29. http://dx.doi.org/10.1128/jvi.02616-08.

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ABSTRACT Nonhuman primates host a plethora of potentially zoonotic microbes, with simian retroviruses receiving heightened attention due to their roles in the origins of human immunodeficiency viruses type 1 (HIV-1) and HIV-2. However, incomplete taxonomic and geographic sampling of potential hosts, especially the African colobines, has left the full range of primate retrovirus diversity unexplored. Blood samples collected from 31 wild-living red colobus monkeys (Procolobus [Piliocolobus] rufomitratus tephrosceles) from Kibale National Park, Uganda, were tested for antibodies to simian immunod

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Dissertations / Theses on the topic "Retroviruses; Tax"

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Smith, Richard E. T. "The functional analysis of naturally occurring Rex mutants in human T-cell lymphotropic virus type I (HTLV-I) infected patients." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362109.

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Folio, Christelle. "Études fonctionnelle et structurale de deux protéines rétrovirales d’intérêt thérapeutique : la protéine Tax du virus HTLV et la protéine de capside du FIV." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1245/document.

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Les rétrovirus sont un enjeu de santé publique, aussi bien humaine qu'animale. La compréhension des déterminants structuraux sous-jacents à la fonction de leurs protéines constitue une étape essentielle dans le développement de stratégies antirétrovirales efficaces.Ce manuscrit porte sur l'étude des bases structurales des mécanismes moléculaires impliqués dans les fonctions clés des rétrovirus que sont i) la régulation de l'expression des protéines de rétrovirus complexes et ii) l'assemblage des particules virales, à travers l'étude de deux protéines rétrovirales d'intérêt thérapeutique : la p

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Lanigan, Lisa Gooding. "Effects of Two Cancer Genes, HTLV-1 Tax and E-Cadherin, on Cancer Development and Progression." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1339177362.

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Rahimi, Khameneh Shabnam. "Assessment of Retroviruses as Potential Vectors for the Cell Delivery of Prions." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23472.

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Transmissible spongiform encephalopathies (TSEs) or prion diseases are a class of fatal brain disorders better known as Creutzfeldt-Jacob Disease (CJD) in humans, bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep, and chronic wasting disease (CWD) in deer and elk. The infectious agent responsible for these diseases is a misfolded prion protein capable of catalyzing a conformational change in normal cellular prion proteins (PrPC) into aberrant disease-causing structural isoforms (PrPSc). Although the etiological agent for TSEs has clearly been defined as PrPSc, there are import

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El, Dassouki Zeina. "Ciblage thérapeutique de l'oncoprotéine virale Tax dans les Leucémies/Lymphomes T de l'adulte (ATL) associées au retrovirus HTLV-I." Paris 7, 2014. http://www.theses.fr/2014PA077093.

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L'ATL est une prolifération tumorale de cellules lymphoïdes T matures activées ; cette maladie est caractérisée par un mauvais pronostic, du fait d'une resistance importante à la chimiothérapie conventionnelle. L'oncoprotéine TAX joue un rôle primordial dans la prolifération et la transformation des lymphocytes infectées par HTLV-1. Notre équipe a montré que l'arsenic synergise avec l'interferon pour induire dans les cellules leucémiques infectées, un arrêt du cycle cellulaire, une apoptose massive ainsi qu'une dégradation proteosomique spécifique de TAX. Cette dégradation semble être à la bas

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ROUSSET, RAPHAEL. "Caracterisation des interactions entre l'oncoproteine tax1 du retrovirus htlv-i et differents facteurs cellulaires impliques dans le controle de la transcription et de la proliferation." Lyon, École normale supérieure (sciences), 1997. http://www.theses.fr/1997ENSL0069.

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L'infection par le retrovirus htlv-i entraine divers syndromes proliferatifs et degeneratifs chez l'homme. La proteine tax1, produite par le virus, possede des activites transactivatrices et oncogeniques qui sont en grande partie responsables des pathologies associees a htlv-i. Les etudes que nous avons engagees ont permis de caracteriser plusieurs proteines qui interagissent avec tax1 dans la cellule. Des etudes effectuees in vivo et in vitro montrent que tax1 favorise la premiere etape de la mise en place du complexe d'initiation de la transcription, en recrutant directement tfiid. Par aille

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Serriere, Jennifer. "Études fonctionnelles et structurales de protéines rétrovirales, Gag du FIV et Tat du VIH-1, à des fins thérapeutiques et vaccinales." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10167.

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Depuis sa découverte il y a plus de 30 ans, le Virus de l’Immunodéficience Humaine est à l’origine d’une importante mortalité dans le monde. De par la difficulté de tester l’efficacité de formulations thérapeutiques et/ou vaccinales directement chez l’homme, des études d’infections modèles du VIH, comme celle du Virus de l’Immunodéficience Féline (FIV), ont été entreprises ces dernières années. Au-delà de son intérêt vétérinaire, l’étude du FIV représente un avantage important pour trouver un moyen de contrôler les infections par les lentivirus tel que le VIH. Elle peut permettre de développer

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Larocque, Émilie. "Caractérisation des transcrits antisens chez les rétrovirus HTLV et étude comparative des fonctions des protéines traduites à partir de ces transcrits antisens." Thèse, 2015. http://hdl.handle.net/1866/13038.

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Le premier membre de la famille des rétrovirus humains HTLV (Virus T-lymphotropique Humain), HTLV-1, a été découvert en 1980 et l’on estime aujourd’hui à plus de 10 millions le nombre d’individus infectés à travers le monde. Après une période de latence d’environ 40 ans, 5% des individus infectés développent des leucémies, des lymphomes adultes de lymphocytes T (ATLL) ou encore une myélopathie associée à HTLV-1/ paraparésie spastique tropicale (HAM/TSP). L’apparition de la maladie serait en grande partie orchestrée par deux protéines virales, soit Tax et HTLV-1 bZIP factor (HBZ). L’expression

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Book chapters on the topic "Retroviruses; Tax"

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Yoshida, M., T. Suzuki, J. Fujisawa, and H. Hirai. "HTLV-1 Oncoprotein Tax and Cellular transcription Factors." In Transacting Functions of Human Retroviruses. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-78929-8_4.

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Gaynor, R. B. "Regulation of HIV-1 Gene Expression by the Transactivator Protein Tat." In Transacting Functions of Human Retroviruses. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-78929-8_3.

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Forlani, Greta, Roberto S. Accolla, and Giovanna Tosi. "Investigating Human T Cell Lymphotropic Retrovirus (HTLV) Tax Function with Molecular and Immunophenotypic Techniques." In Methods in Molecular Biology. Humana Press, 2014. http://dx.doi.org/10.1007/978-1-62703-670-2_24.

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Conference papers on the topic "Retroviruses; Tax"

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Safonov, A., G. Bianchini, T. Jiang, L. Pusztai, and C. Hatzis. "Abstract P4-04-20: Subtype specific differential expression and immunogenicity of endogenous retrovirus elements in breast cancer." In Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-p4-04-20.

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