Dissertations / Theses on the topic 'Retinopathy'
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Sampedro, Vida Joel. "Desarrollo de un tratamiento tópico en colirio para la retinopatia diabética basado en el efecto neuroprotector de GLP-1." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670819.
Full textLa retinopatía diabética (RD) es la complicación más frecuente de la diabetes y representa la primera causa de ceguera en población en edad laboral en países desarrollados. Se trata de una patología progresiva que afecta a la unidad neurovascular de la retina e implica alteraciones en la microcirculación, la glía y las neuronas de la retina como consecuencia de la propia hiperglucemia y las vías patogénicas que desencadena. Previamente, nuestro grupo demostró que el péptido similar al glucagón (GLP-1) está disminuido en las retinas de donantes diabéticos y es capaz de ejercer efectos neuroprotectores en modelos experimentales de diabetes. El objetivo general de esta tesis es reunir una evidencia preclínica sólida que de soporte científico a ensayos clínicos dirigidos a tratar las etapas iniciales de la RD mediante la administración tópica ocular de fármacos agonistas del receptor del GLP-1 (GLP-1RAs) y fármacos inhibidores de la enzima que metaboliza el GLP-1, la DPP-IV (DPP-IVi), en un modelo de diabetes experimental, el ratón db/db.
Diabetic retinopathy (RD) is the most common complication of diabetes and it is the first cause of blindness in adults of developed countries. RD is a progressive pathology that affects the neurovascular unit of retina in which microvessels, glial cells and neurons are damaged as a consequence of hyperglycemia. In a previous study, our group showed that: 1) The content of glucagon-like peptide 1 (GLP-1) was decreased in diabetic retinas and, 2) GLP-1 exerted neuroprotective effects in DR experimental model. The overarching aim of this thesis is to achieve preclinical evidence which permit us the the design of clinical trials for treating early stages of DR with either agonists of GLP-1 receptor (GLP-1RAs) or inhibitors of the enzyme DPP-IV (DPP-IVi), which increase the life span of GLP-1. For this purpose, we used the experimental animal model of type 2 diabetes, the db/db mouse (BKS.Cg-Dock7m +/+ Leprdb/J).
Mahon, Gerald J. "Studies on chloroquine retinopathy." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388235.
Full textLoukovaara, Sirpa. "Diabetic retinopathy and pregnancy." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/loukovaara/.
Full textDe, la Torre Gallart Jordi. "Diabetic Retinopathy Classification and Interpretation using Deep Learning Techniques." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/667077.
Full textLa retinopatía diabética es una enfermedad crónica y una de las principales causas de ceguera y discapacidad visual en los pacientes diabéticos. El examen ocular a través de imágenes de la retina es utilizado por los médicos para detectar las lesiones relacionadas con esta enfermedad. En esta tesis, exploramos diferentes métodos novedosos para la clasificación automática del grado de enfermedad utilizando imágenes del fondo de la retina. Para este propósito, exploramos métodos basados en la extracción y clasificación automática, basadas en redes neuronales profundas. Además, diseñamos un nuevo método para la interpretación de los resultados. El modelo está concebido de manera modular para que pueda ser utilizado utilizando otras redes y dominios de clasificación. Demostramos experimentalmente que nuestro modelo de interpretación es capaz de detectar lesiones de retina en la imagen únicamente a partir de la información de clasificación. Además, proponemos un método para comprimir la representación interna de la información de la red. El método se basa en un análisis de componentes independientes sobre la información del vector de atributos interno de la red generado por el modelo para cada imagen. Usando nuestro método de interpretación mencionado anteriormente también es posible visualizar dichos componentes en la imagen. Finalmente, presentamos una aplicación experimental de nuestro mejor modelo para clasificar imágenes de retina de una población diferente, concretamente del Hospital de Reus. Los métodos propuestos alcanzan el nivel de rendimiento del oftalmólogo y son capaces de identificar con gran detalle las lesiones presentes en las imágenes, que se deducen solo de la información de clasificación de la imagen.
Diabetic Retinopathy is a chronic disease and one of the main causes of blindness and visual impairment for diabetic patients. Eye screening through retinal images is used by physicians to detect the lesions related with this disease. In this thesis, we explore different novel methods for the automatic diabetic retinopathy disease grade classification using retina fundus images. For this purpose, we explore methods based in automatic feature extraction and classification, based on deep neural networks. Furthermore, as results reported by these models are difficult to interpret, we design a new method for results interpretation. The model is designed in a modular manner in order to generalize its possible application to other networks and classification domains. We experimentally demonstrate that our interpretation model is able to detect retina lesions in the image solely from the classification information. Additionally, we propose a method for compressing model feature-space information. The method is based on a independent component analysis over the disentangled feature space information generated by the model for each image and serves also for identifying the mathematically independent elements causing the disease. Using our previously mentioned interpretation method is also possible to visualize such components on the image. Finally, we present an experimental application of our best model for classifying retina images of a different population, concretely from the Hospital de Reus. The methods proposed, achieve ophthalmologist performance level and are able to identify with great detail lesions present on images, inferred only from image classification information.
Teng, Thomas Bart. "Vessel identification in diabetic retinopathy." Thesis, Bournemouth University, 2003. http://eprints.bournemouth.ac.uk/441/.
Full textHillman, Nicola Jane. "Hypertension and experimental diabetic retinopathy." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241987.
Full textPenishkevich, Ya I. "Pathophysiological mechanisms of diabetic retinopathy." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18637.
Full textMohamed, Shaheeda. "Efficacy of intravitreal triamcinolone in diabetic macular edema." Thesis, View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38479114.
Full textHeintz, Emelie. "Health economic aspects of diabetic retinopathy." Doctoral thesis, Linköpings universitet, Utvärdering och hälsoekonomi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76283.
Full textBrooks, Roger Audley. "Fibroblast growth factor and diabetic retinopathy." Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46684.
Full textvan, Wijngaarden Peter, and petervanwijn@yahoo com au. "Heritable influences in oxygen-induced retinopathy." Flinders University. Medicine, 2006. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20060824.211102.
Full textCox, Orla T. "Vascular cell death in diabetic retinopathy." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343079.
Full textCorraliza, Márquez Lidia. "Neurodegeneration as an early event in the pathogenesis of diabetic retinopathy: therapeutic implications." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/399840.
Full textDiabetic retinopathy (DR) is the most common complication of diabetes and one of the leading causes of preventable blindness. DR has been classically considered to be a microcirculatory disease of the retina. However, before any microcirculatory abnormalities can be detected under ophthalmoscopic examination, retinal neurodegeneration is already present. This is to say that retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy. There is a need to have a good animal model where potentially neuroprotective drugs could be tested on and understand their mechanisms of action. In the first chapter of this thesis the main aim was to characterize the sequential events that take place in retinal neurodegeneration in a murine model of spontaneous type 2 diabetes, the db/db mouse. We found progressively increased levels of the histological markers of neurodegeneration (glial activation and apoptosis) at all stages studied worsening with age. Significant electroretinographic abnormalities were present in diabetic mice at weeks 16 and 24 but not at week 8. Moreover it was observed a progressive accumulation of glutamate in diabetic mice associated with an early downregulation of its transporter GLAST. All this abnormalities were abrogated by lowering blood glucose levels. Finally, a dysregulation of several genes related to neurotransmission and oxidative stress such as UCP2 were found at week 8. All these results suggest that db/db mouse reproduce the features of the neurodegenerative process that occurs in the human diabetic eye. Therefore it is an appropriate model for investigating the underlying mechanisms of diabetes induced retinal neurodegeneration and for testing neuroprotective drugs. In the second chapter the potential effects of fenofibric acid (FA) (the active metabolite of fenofibrate) in preventing retinal neurodegeneration in the db/db mouse are evaluated. Oral treatment for one week resulted in a reduction of glial activation and apoptosis in comparison to vehicle-treated mice. Functional abnormalities were ameliorated and FA treatment also prevented GLAST downregulation induced by diabetes. Our results suggest that neuroprotection is one of the underlying mechanisms by which FA exerts its beneficial actions in diabetic retinopathy. The third chapter is focused on GLP-1 and its neuroprotective effects in the retina. GLP-1 has been demonstrated to have neuroprotective effects in the central nervous system. We sought to examine the expression and content of GLP-1R in human and db/db mice retinas, to determine the retinal neuroprotective effects of systemic and topical administration of GLP-1R agonists in db/db mice and, to examine the underlying neuroprotective mechanisms. We found abundant expression of GLP-1R in the human retina and retinas from db/db mice. Moreover, it has been demonstrated that systemic administration of GLP-1R agonists (liraglutide) prevents retinal neurodegeneration (glial activation, neural apoptosis and electroretinographical abnormalities). This effect can be attributed to a significant reduction of extracellular glutamate and to an increase of prosurvival signalling pathways. We have found a similar neuroprotective effect using topical administration of native GLP-1 and several GLP-1R agonists (liraglutide, lixisenatide and exenatide). Notably, this neuroprotective action was observed without any reduction in blood glucose levels. These results suggest that GLP-1R activation itself prevents diabetes induced retinal neurodegeneration.
Southern, Danielle A. "The measurement of progression of diabetic retinopathy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq65135.pdf.
Full textAriffin, Azrin Esmady. "Visual function in patients with diabetic retinopathy." Thesis, City University London, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283151.
Full textLaughlin, William Edward. "Angiogenesis and vascular leakage in diabetic retinopathy." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10043874/.
Full textLiu, Yiyuan. "Clinical and genetic determinants of diabetic retinopathy." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/5ac68285-0104-489d-9aad-c4b5dc15084f.
Full textLeontidis, Georgios. "Early screening and diagnosis of diabetic retinopathy." Thesis, University of Lincoln, 2016. http://eprints.lincoln.ac.uk/26473/.
Full textTonade, Deoye. "ROLE OF PHOTORECEPTOR CELLS IN DIABETIC RETINOPATHY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1505440070603758.
Full textHenricsson, Marianne. "Hyperglycaemia and diabetic eye complications a clinical and epidemiological study /." Lund : Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39736643.html.
Full textTam, Ka-wae Tammy. "Prevalence, risk factors and progression of diabetic retinopathy in Chinese elderly with type 2 diabetes mellitus : evidence for recommended screening interval /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36434346.
Full textSaleh, Ali Ali Emran. "Development of Machine Learning Techniques for Diabetic Retinopathy Risk Estimation." Doctoral thesis, Universitat Rovira i Virgili, 2020. http://hdl.handle.net/10803/670493.
Full textLa retinopatía diabética (RD) es una enfermedad crónica. Es una de las principales complicaciones de diabetes y una causa esencial de pérdida de visión entre las personas que padecen diabetes. Los pacientes diabéticos deben ser examinados periódicamente para detectar signos de diabetes. desarrollo de retinopatía en una etapa temprana. La detección temprana y frecuente disminuye el riesgo de pérdida de visión y minimiza la carga en los centros de salud. El número de pacientes diabéticos es enorme y está aumentando rápidamente, lo que lo hace difícil y Consume recursos para realizar una evaluación anual para todos ellos. El objetivo principal de esta tesis es construir un sistema de apoyo a la decisión clínica (CDSS) basado en datos de registros de salud electrónicos (EHR). Este CDSS será utilizado para estimar el riesgo de desarrollar RD. En este tesis doctoral se estudian métodos de aprendizaje automático para construir un CDSS basado en reglas lingüísticas difusas. El conocimiento expresado en este tipo de reglas facilita que el médico pueda saber que combinaciones de las condiciones son las que pueden provocar el riesgo de desarrollar RD. En este trabajo propongo un método para reducir la incertidumbre en la clasificación de los pacientes que usan árboles de decisión difusos (FDT). A continuación se combinan diferentes árboles usando la técnica de Fuzzy Random Forest para mejorar la calidad de la predicción. Se proponen también varias políticas para fusionar los resultados de que nos da cada uno de los árboles (FDT). Para mejorar la decisión final propongo tres medidas difusas que se usan con las integrales Choquet y Sugeno. La definición de estas medidas difusas se basa en los valores de confianza de las reglas. En particular, uno de ellos es una medida difusa descomponible en la que se usa la estructura jerárquica del FDT para encontrar los valores de la medida difusa. Como resultado final de la investigación se ha construido un software que puede instalarse en centros de atención médica y hospitales, i que puede ser usado por los médicos de cabecera para hacer la evaluación preventiva y el cribado de la Retinopatía Diabética.
Diabetic retinopathy (DR) is a chronic illness. It is one of the main complications of diabetes, and an essential cause of vision loss among people suffering from diabetes. Diabetic patients must be periodically screened in order to detect signs of diabetic retinopathy development in an early stage. Early and frequent screening decreases the risk of vision loss and minimizes the load on the health care centres. The number of the diabetic patients is huge and rapidly increasing so that makes it hard and resource-consuming to perform a yearly screening to all of them. The main goal of this Ph.D. thesis is to build a clinical decision support system (CDSS) based on electronic health record (EHR) data. This CDSS will be utilised to estimate the risk of developing RD. In this Ph.D. thesis, I focus on developing novel interpretable machine learning systems. Fuzzy based systems with linguistic terms are going to be proposed. The output of such systems makes the physician know what combinations of the features that can cause the risk of developing DR. In this work, I propose a method to reduce the uncertainty in classifying diabetic patients using fuzzy decision trees. A Fuzzy Random forest (FRF) approach is proposed as well to estimate the risk for developing DR. Several policies are going to be proposed to merge the classification results achieved by different Fuzzy Decision Trees (FDT) models to improve the quality of the final decision of our models, I propose three fuzzy measures that are used with Choquet and Sugeno integrals. The definition of these fuzzy measures is based on the confidence values of the rules. In particular, one of them is a decomposable fuzzy measure in which the hierarchical structure of the FDT is exploited to find the values of the fuzzy measure. Out of this Ph.D. work, we have built a CDSS software that may be installed in the health care centres and hospitals in order to evaluate and detect Diabetic Retinopathy at early stages.
Simó, Servat Olga. "Neurodegeneration and inflammation: two crucial pathogenic events in diabetic retinopathy. New experimental insights and clinical perspectives." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/666822.
Full textNeurodegeneration is an early event in the pathogenesis of diabetic retinopathy (DR). In fact, the American Diabetes Association has recently defined DR as a highly tissue-specific neurovascular complication, thus emphasizing the importance of the neurovascular unit in the development of DR. The retina is a brain-derived tissue and there is growing evidence indicating that type 2 diabetic subjects are more prone to develop neurodegenerative processes such as Alzheimer’s disease. Therefore, it seems reasonable to postulate that the mediators of the neurodegenerative process that occurs in the brain could also be present in the diabetic retina. On this basis, the general objective of this thesis is to investigate the relationship between retinal and brain neurodegeneration and its potential clinical and therapeutic implications. The first part of this thesis focuses on experimental studies addressed to identifying mediators of impairment of the neurovascular unit. For this purpose a proteomic “hypothesis-free” study was performed comparing human retinas from non-diabetic and diabetic donors with and without glial activation (one of the hallmarks of retinal neurodegeneration). The Ingenuity Pathway Analysis revealed that several critical pathways related to brain neurodegenerative diseases were differently expressed in retinas from diabetic patients and in particular in those with glial activation. This observation supports the concept that a common soil exists in the neurodegenerative processes that occur in the retina and the brain. In addition, a downregulation of several proteins involved in axonal transport and the cytoskeleton was found in retinas from diabetic donors with glial activation. Furthermore, diabetes-induced glial activation was associated with a dysregulation of the complement system, as well as an upregulation of the proteins that govern the cytoskeleton changes. These results were confirmed by orthogonal methods. These novel findings contribute not only to our understanding of the mechanisms involved in the vascular leakage induced by neurovascular unit impairment, but could also have potential therapeutic implications. The second part of this doctoral thesis is based on a “driven hypothesis” aimed at examining whether endothelin-1 plays a pivotal role in the neurovascular unit impairment that occurs in DR. This is based on the fact that by means of ETA receptors ET-1 leads to vascular damage and through ETB induces neurodegeneration. We first found an overexpression of both ET-1 and its receptors (ETA and ETB) in the retinas from diabetic donors in comparison with nondiabetic donors. Second, we found that topical administration of bosentan (a blocker of ETA and ETB receptors) prevented retinal neurodegeneration induced by diabetes in the db/db mouse model. In addition, the inhibition of diabetes-induced upregulation of PKC-β, TNF-α and VEGF plays an important role in the beneficial vascular action of bosentan. These dual beneficial effects of bosentan (neurotrophic and vasculotropic) and the pharmacokinetic results point to this drug as an excellent candidate to be tested in clinical trials. The third part of the thesis is a clinical study addressed to reinforcing the concept that the assessment of retinal neurodegeneration could be a useful tool to identify those diabetic subjects at risk of developing dementia. Indeed, in a previous study we demonstrated that retinal sensitivity assessed by fundus-driven microperimetry was related to brain neurodegeneration and could be a useful biomarker for identifying patients with T2D who are at risk of developing Alzheimer’s disease. In the present work, we assessed whether gaze fixation, a parameter that can also be assessed by retinal microperimetry, is associated with cognitive impairment. This is based on previous evidence indicating that the capacity to maintain visual gaze on a single location (fixation) is hampered in Alzheimer’s disease. Our results showed that gaze fixation is more unstable as cognitive impairment progresses. Moreover the assessment of fixational parameters significantly improves retinal sensitivity assessment in differentiating those subjects with mild cognitive impairment from normocognitive diabetic subjects. Therefore, the measurement of retinal sensitivity in combination with parameters of fixation by using microperimetry could be a reliable method for detecting prodromal stages of dementia in the T2D population. Hopefully, these findings will be the proof of concept of a large scale-clinical study. Overall, this work contributes to the knowledge of the mediators of neurovascular unit impairment in the early stages of DR and increases our understanding of the link between retinal and brain neurodegeneration in the setting of the type 2 diabetic population. In addition, our findings suggest further candidates as new potential targets for the treatment of DR.
Cheung, Shiu-fai. "Effects of endothelial cell-specific over-expression of endothelin-1 on diabetic and ischemic retinopathy." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36923060.
Full textWatson, Matthew. "Diabetic retinopathy screening in Australia: attitudes in primary care settings and the validation of artificial intelligence approaches." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25084.
Full textGustafsson, Sebastian. "Sight-threatening Diabetic Retinopathy in a Swedish County – : Prevalence and Comparison of Patients with and without Sight-threatening Diabetic Retinopathy." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-66795.
Full textAlexander, Henry George. "Factors associated with diabetic retinopathy requiring treatment on fundal photography in participants of the Cape Town diabetic retinopathy screening programme." University of the Western Cape, 2016. http://hdl.handle.net/11394/5498.
Full textBACKGROUND AND RATIONALE: The Cape Town Metro District Health Service (MDHS) has introduced a Diabetic RetinopathyScreening (DRS) programme incorporating retinal fundal photography in diabetic services at primary health care (PHC) facilities. Hitherto, coverage of the DRS programme has been less than optimal in part due to volumes of diabetic patients attending PHC facilities. The aim of this study was to identify possible sub-groups of patients, attending the Cape Town DRS Programme, who are at most risk of diabetic retinopathy and might be prioritised for early diabetic retinopathy detection and subsequent sight-saving treatment. METHODOLOGY: A case-control study of risk factors for treatment-requiring diabetic retinopathy was conducted. This research sampled participants from the DRS programme provided by the MDHS eye care team to Type II diabetics attending public PHC facilities within the Klipfontein and Mitchells Plain Sub-Districts. Based on fundal images, cases were selected as those requiring ophthalmological treatment; and controls (three matched per case by area of residence) as those judged as not requiring ophthalmological treatment for diabetic retinopathy. Data on possible risk factors (clinical, laboratory) were extracted from the patients' folders. RESULT: The study included 453 participants, of whom 113 (24.9%) were cases and 340 (75.1%) were controls. Three factors were significantly associated with treatment-requiring diabetic retinopathy on multivariate analysis: Insulin dependency (OR of 2.96, 95% CI: 1.75 – 5.00); duration of diabetes of more than 10 years (OR of 3.44, 95% CI: 2.06 – 5.74) and sustained hyperglycaemia over the past six months (OR of 3.73, 95% CI: 1.69 – 8.22). A screening algorithm combining these criteria had a sensitivity of 61.2% (95% CI: 51.9 – 70.5). CONCLUSION: The findings indicate that a sub-set of patients attending the DRS programme in the Klipfontein and Mitchells Plain Sub-Districts have a greater likelihood of presenting with treatment-requiring diabetic retinopathy. Further research is required to develop a tool that is sufficiently sensitive to safely prioritise patients for fundal screening.
National Research Foundation (NRF)
Basu, Ansu. "Diabetic retinopathy screening using advanced digital imaging technology." Thesis, University of Newcastle upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413265.
Full textGibson, Donna Lee. "Retinopathy of prematurity in British Columbia, 1952-1983." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26261.
Full textMedicine, Faculty of
Population and Public Health (SPPH), School of
Graduate
Wendt, Gunvor von. "Screening for diabetic retinopathy : aspects of photographic methods /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-398-1/.
Full textSinthanayothin, Chanjira. "Image analysis for automatic diagnosis of diabetic retinopathy." Thesis, King's College London (University of London), 1999. https://kclpure.kcl.ac.uk/portal/en/theses/image-analysis-for-automatic-diagnosis-of-diabetic-retinopathy(163f8067-329d-4a48-b214-0ea70ba828d4).html.
Full textArun, Chankramath S. "Retinopathy screening : prevention of blindness due to diabetes." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427289.
Full textGoh, Kheng Guan. "Computer assisted photocoagulation for treatment of diabetic retinopathy." Thesis, Teesside University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410911.
Full textUsher, David Benjamin. "Image analysis for the screening of diabetic retinopathy." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404601.
Full textCrosby-Nwaobi, Roxanne. "The relationship between diabetic retinopathy and cognitive impairment." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/the-relationship-between-diabetic-retinopathy-and-cognitive-impairment(762590a4-0446-415e-baec-2a7361757125).html.
Full textLiu, Haitao. "NEUTROPHIL ELASTASE CONTRIBUTES TO THE EARLY DIABETIC RETINOPATHY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1552485945496003.
Full textSabtu, K. "Evaluation of diabetic retinopathy screening in Brunei Darussalam." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2015. http://researchonline.lshtm.ac.uk/2391561/.
Full textDow, Courtney. "Dietary Factors, Type 2 Diabetes and Diabetic Retinopathy." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS380/document.
Full textBackground : Type 2 diabetes (T2D) presents a significant health burden that is associated with many complications, such as diabetic retinopathy (DR), that further burden people with diabetes. Modifiable risk factors, such as the diet, have been identified for both T2D and DR; yet certain aspects of the role of the diet remain unclear. Objectives : The main objectives of this thesis were therefore to examine the role and impact of the diet, and in particular, the consumption of fatty acids (FAs), and other modifiable behaviours on the risk of T2D and to summarize, interpret and analyze the relationship between the diet and DR using data from both the E3N and AusDiab cohort studies. Results : The results suggest that the role of FAs on the risk of T2D and DR may differ between and within subgroups, and by individual polyunsaturated fatty acids (PUFAs). The findings also suggest that strongly adhering to national dietary guidelines is not associated with the development of T2D, but strongly adhering to other recommendations for healthy behaviours (for waist circumference, physical activity and smoking) is strongly inversely associated with T2D. Modifiable behaviour could have prevented more than half of the cases of T2D. Conclusions : This work underlines the importance and the complexity of the role of the diet in the development of T2D and DR. It also illustrates the impact of healthy behaviour in the etiology of T2D and confirms that T2D is largely preventable. Efforts should focus on the modification of multiple healthy behaviours in populations, and promote diets that are moderate and widely varied
Cury, Junior Carlos Eduardo. "Prevalência da retinopatia diabética em unidades básicas de saúde de São José do Rio Preto-SP." Faculdade de Medicina de São José do Rio Preto, 2010. http://bdtd.famerp.br/handle/tede/132.
Full textDiabetic retinopathy (DR) is one of the most frequent causes of legal blindness worldwide and the most common microvascular complication of the disease. During the first two decades, almost all patients of type I and more than 60% of the patients of type II have developed the disease. Studies to determinate the prevalence of DR in a certain population are an important measure to delineate screening programs. Objective: To determine the prevalence of Diabetic Retinopathy in public health care units of São José do Rio Preto-SP-Brazil. Material and methods: Population-based cross-sectional study. The study sample, of 710 patients, was derived from the HIPERDIA (Diabetes and High-blood pressure social health care program) of São José do Rio Preto. Participants were also interviewed and examined to determine their demographic characteristics, medical conditions and the realization of previous fundoscopic eye examination All patients, known to have diabetes, underwent an eye examination by indirect ophthalmoscope to check for any signs of DR through dilated pupils.. Statistical studies were done with t-Student test, Fisher test or chi-square test.. Results: The prevalence of DR were 16,3%. Patients were divided in two groups: Group I, patients with DR 112 (16,3%) and Group II , patients without microvascular complication of diabetes 597 (83,7%) . In Group I 90 (80,4%) demonstrated non-proliferative and (22) 19,6% with proliferative diabetic retinopathy. Only 143 patients (68,7%) had a history of previous fundoscopic eye examination. Conclusions: The prevalence of DR in São José do Rio Preto is 16,3%. The main risk factors associated with DR were time of disease and glicemic control. Type of DM and nephropathy were considered secondary risk factors. The presence of high blood pressure, in this study, was not a risk factor associated with DR.
A retinopatia diabética (RD) é uma das principais causas de cegueira em todo o mundo e a principal complicação microvascular da doença. Durante as duas primeiras décadas da evolução da doença, praticamente todos os pacientes com diabetes do tipo 1 e mais de 60% dos pacientes com diabetes do tipo 2 desenvolvem retinopatia. Estudos para determinar a prevalência da RD em uma determinada população são uma importante medida. Estes facilitam o planejamento de campanhas para a prevenção e a detecção da doença.Objetivo: Determinar a prevalência e o estadiamento da retinopatia diabética (RD) em unidades básicas de saúde de São José do Rio Preto-SP - Brasil.Casuística e métodos: Estudo epidemiológico descritivo transversal, no qual foram examinados 710 pacientes diabéticos, cadastrados no programa HIPERDIA (Hipertensos e Diabéticos) da Secretaria Municipal de Saúde de SJRP. Os pacientes responderam a questionário, que incluía: idade, tempo de duração do diabetes, medicação utilizada para o controle glicêmico, tratamento para hipertensão arterial sistêmica, hiperlipidemia ou nefropatia e realização de exame fundoscópico prévio. Os dados complementares, como o valor da HbA1c e como o tipo do diabetes (tipos 1 ou 2), foram extraídos dos respectivos prontuários. Após a dilatação pupilar, foi realizado o exame de fundo de olho, por oftalmoscopia indireta. Os métodos estatísticos utilizados para a análise foram: teste t-Student, teste de Fisher ou teste qui-quadrado. Em todos os testes estatísticos, o nível de significância adotado foi de 5%.Resultados: A prevalência da RD foi de 16,3%. Os pacientes estudados foram divididos em dois grupos: Grupo I, de pacientes com RD 112 (16,3%) e Grupo II, de pacientes sem a complicação microvascular do diabetes 597 (83,7%). Com relação à classificação da RD, apresentada pelos pacientes do Grupo I, verificou-se que noventa (80,4%) dos pacientes apresentaram a forma não proliferativa da doença (RDNPF). Do total de pacientes, 68,7% foram anteriormente submetidos ao exame de fundoscopia. Conclusões: A prevalência da RD, em São José do Rio Preto, está estimada em 16,3%. Os principais fatores de risco associados à RD foram o tempo de doença e o controle glicêmico. O tipo de DM e a presença de nefropatia foram considerados fatores de risco secundários para o desenvolvimento da RD. Neste estudo, a presença de HAS não foi considerada fator de risco associado a RD.
Lian, Jinxiao, and 連金晓. "An evaluation of systematic screening for diabetic retinopathy in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196489.
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Public Health
Doctoral
Doctor of Philosophy
Navarro, Sanz Miriam. "Proteomic and metabolomic approaches to study diabetic retinopahty." Doctoral thesis, Universitat Rovira i Virgili, 2018. http://hdl.handle.net/10803/670958.
Full textEl objetivo general de esta tesis doctoral fue desarrollar, analizar y validar nuevas herramientas bioinformáticas que conviertan los datos crudos de metabolómica (adquiridos por espectrometría de masas) en conocimiento biológico con el fin de estudiar las alteraciones en el proteoma y metaboloma de células humanas del pigmento retinal expuestas a condiciones de hiperglucemia y / o hipoxia. ⁻ Objetivos metodológicos: (i) Hemos analizado las bases de datos espectrales de masas de metabolómica basada en LC / MS. (ii) Finalmente, hemos generado y mejorado la caracterización de los datos de metabolómica de LC / MS centrándonos en la anotación de MS1 y MS2. ⁻ Objetivos biológicos: (iii) Hemos propuesto un nuevo método que detecta y analiza los cambios en las redes de interacción proteína-proteína (PPI) por condiciones hiperglucemia y / o hipoxia. (iv) Hemos presentado un flujo de trabajo novedoso que es capaz de predecir y validar las alteraciones metabólicas debidas a condiciones hiperglucemia y / o hipoxia integrando a la vez los datos de expresión de proteínas en las redes metabólicas.
The general objective of this doctoral thesis was to develop, analyse and validate new bioinformatic tools for converting raw MS-based metabolomics data into biological knowledge, in order to study alterations in the proteome and metabolome of human retinal pigment epithelium cells exposed to hyperglycemic and/or hypoxic conditions. To reach this general objective, this thesis has been structured in two main blocks: ⁻ Methodological aims: (i) We have analysed mass spectral databases for LC/MS-based untargeted metabolomics. (ii) Finally, we have generated and improved the characterization of LC/MS metabolomics data focusing on MS1 and MS2 annotation. ⁻ Biological aims: (iii) We have proposed a novel method that detects and analyses changes in protein-protein interaction (PPI) networks by hyperglycemic and/or hypoxic conditions. (iv) We have presented a novel workflow which is able to predict and validate metabolite alterations due to hyperglycemic and/or hypoxic conditions integrating protein expression data in metabolic networks.
Dembinska-Knypinski, Olga. "Structural and functionnal [sic] consequences of oxygen induced retinopathy." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36907.
Full textOur results indicate that there is a sigmoidal dose-response correlation between the increasingly longer duration of oxygen exposure, and the decrease in the postreceptoral retinal activity, as revealed by the gradual reduction in the amplitudes of rod and cone dominated b-waves and oscillatory potentials. Furthermore, the cone function appeared to be slightly more affected than that of the rod. Also, of all the ERG components the oscillatory potentials, especially the short latency ones, appeared to be the most sensitive to the hyperoxia. The gradual thinning of the outer plexiform layer (OPL) is also correlated with the duration of oxygen exposure, while the reduction in the number of horizontal cells is not.
Secondly, our experimental approach has allowed us to evidence a period of higher oxygen susceptibility (a window), which takes place during the second week of life of the newborn rats, more specifically around postnatal day 10. Several oxygen exposures of short duration, which included this period, were shown to be more detrimental to the rod and cone function than longer exposures taking place prior to or after this window. This would suggest that during the normal maturation process, the immature retina is not equally sensitive to the hyperoxic insult, presumably because specific retinal structures (synapses in OPL) are targeted by oxygen.
Finally, Trolox C, a potent water-soluble antioxidant, partially prevents the functional and structural consequences of OIR. The prophylactic effect appears to benefit more the rod function than that of the cone.
To conclude, we believe that this new knowledge will help us understand the pathophysiological processes at the origin of oxygen toxicity in the immature retina, thus, significantly increasing our insights on the human form of this disease, namely ROP, which as a result, will be instrumental in devising new therapeutic avenues to help fight this potentially debilitating retinal disorder.
Olson, J. A. "Digital imaging, leucocytes, gamma-linolenic acid and diabetic retinopathy." Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.593242.
Full textGoh, Jonathan. "The reading of diabetic retinopathy images - an evolutionary approach." Thesis, University of Surrey, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543272.
Full textGodfrey, Lynne. "Screening for diabetic retinopathy : a hospital based screening service." Thesis, City University London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287666.
Full textStottrup, Casey. "Cell-cell communication in the pathogenesis of diabetic retinopathy." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12642.
Full textPurpose: The goal of this study is to test the hypothesis that high glucose, a prevalent characteristic of diabetes, induces vascular cell death associated with diabetic retinopathy by compromising gap junction intercellular communication. Methods: Cell culture models of hyperglycemia involving endothelial cells, pericytes, and Muller cells were used in this study. Cells were exposed to high glucose (HG: 30 mM) for 7 days and harvested for analysis of Cx43, ZO-1, rab20, and β-actin by Western blot and subsequent densitometric analyses using imageJ software. Immunoprecipitation was performed to identify rab20 by Western blot analysis. Localization and distribution of the tight junction and gap junction proteins were determined by immunostaining. Cells immunostained for Cx43 and ZO-1 were digitally photographed under immunofluorescence microscopy and assessed for protein localization and distribution. To determine the effect of reduced rab20, cells were transfected with rab20 siRNA in the presence of Lipofectin; scrambled siRNA was used as control. To identify cells undergoing apoptosis, TUNEL assay was performed. Results: Western blot analysis revealed that HG significantly reduced Cx43 protein expression in rMC-1 (64% of N) and cocultures of rMC-1 and BRPs (72% of N). Similarly, Cx43 and ZO-1 immunostaining were significantly reduced in these cells grown in HG condition. Western blot analysis also revealed that HG significantly upregulated rab20 (129% of N) protein expression. Under HG condition, an increased number of TUNEL+ cells was detected using TUNEL assay (7.3 vs. 1.5 TUNEL+ cells per 1000 cells). HG cells transfected with rab20 siRNA significantly reduced the number of apoptotic cells (1.5 vs. 7.3 TUNEL+ cells per 1000 cells). Conclusion: Findings from this study indicate that HG-induced disturbed gap junction intercellular communication may contribute to retinal vascular cell and Muller cell apoptosis. HG-induced overexpression of rab20 may play a significant role in reducing Cx43 expression and compromising cell-cell communication associated with the pathogenesis of diabetic retinopathy.
Welikala, Roshan Alex. "Automated detection of proliferative diabetic retinopathy from retinal images." Thesis, Kingston University, 2014. http://eprints.kingston.ac.uk/30591/.
Full textMacCormick, I. "Malarial retinopathy and neurovascular injury in paediatric cerebral malaria." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/2049100/.
Full textAbedi, Natasha. "Retinopathy of prematurity (ROP) in Örebro : a 10-yearperspective." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-86364.
Full textHamilton, Ross Waring. "The role of erythropoietin in protecting against diabetic retinopathy." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546354.
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