Dissertations / Theses on the topic 'Results chain'
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alramadin, manal. "Strategies to Mitigate Negative Results of Supply Chain Disruption." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7909.
Full text郭慈安 and Chi-on Michael Kwok. "Some results on higher order Markov Chain models." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1988. http://hub.hku.hk/bib/B31208654.
Full textKwok, Chi-on Michael. "Some results on higher order Markov Chain models /." [Hong Kong] : University of Hong Kong, 1988. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12432076.
Full textMayer, Peter. "Glassy dynamics and effective temperatures : exact results for spin chain models." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407461.
Full textVidmar, Matija. "Markov chain approximations to, and some fluctuation results for, Lévy processes." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/65625/.
Full textMartineau, Megan, Stephanie Yandow, Stephanie Hines, and Terri Warholak. "Job Satisfaction Among Tucson Area Chain Community Pharmacists: Results from a Pilot Study." The University of Arizona, 2012. http://hdl.handle.net/10150/614488.
Full textSpecific Aims: The purpose of this study was to assess the overall satisfaction of Tucson area pharmacists in the community retail setting and to identify the facets of community practice that have the greatest contribution to job satisfaction and dissatisfaction. Methods: Surveys were sent by facsimile to all community retail pharmacies in the Tucson area. All pharmacists working in these stores were encouraged to respond to the survey by faxing back the paper copy or by responding to the online version of the survey at surveymonkey.com. Respondents were asked to rate their job satisfaction and demographic data were also collected. Main Results: Questionnaires were completed and returned by 32 pharmacists, an estimated response rate of 10%. After reviewing the returned surveys, four questions were chosen from the satisfaction portion to determine their relationship to the job satisfaction ratings. Those four variables were “recognition one receives for good work”, “opportunity to use abilities”, “hours of work”, and “patient contact”. Those four satisfaction variables were then analyzed using the demographic grouping variables “other experience”, “store type” and “degree earned”. Following analysis, only hours of work was found to play a significant role with pharmacy job satisfaction when grouped by other experience. Conclusions: The area of community pharmacy practice that affects job satisfaction the most is hours of work, which is especially true when pharmacists have work experience outside of community practice.
Martineau, Megan, Stephanie Yandow, and Stephanie Hines. "Job Satisfaction Among Tucson Area Chain Community Pharmacists: Results from a Pilot Study." The University of Arizona, 2012. http://hdl.handle.net/10150/623643.
Full textSpecific Aims: The purpose of this study was to assess the overall satisfaction of Tucson area pharmacists in the community retail setting and to identify the facets of community practice that have the greatest contribution to job satisfaction and dissatisfaction. Methods: Surveys were sent by facsimile to all community retail pharmacies in the Tucson area. All pharmacists working in these stores were encouraged to respond to the survey by faxing back the paper copy or by responding to the online version of the survey at surveymonkey.com. Respondents were asked to rate their job satisfaction and demographic data were also collected. Main Results: Questionnaires were completed and returned by 32 pharmacists, an estimated response rate of 10%. After reviewing the returned surveys, four questions were chosen from the satisfaction portion to determine their relationship to the job satisfaction ratings. Those four variables were “recognition one receives for good work”, “opportunity to use abilities”, “hours of work”, and “patient contact”. Those four satisfaction variables were then analyzed using the demographic grouping variables “other experience”, “store type” and “degree earned”. Following analysis, only hours of work was found to play a significant role with pharmacy job satisfaction when grouped by other experience. Conclusions: The area of community pharmacy practice that affects job satisfaction the most is hours of work, which is especially true when pharmacists have work experience outside of community practice.
Vodola, Davide. "Correlations and quantum dynamics of 1D fermionic models : new results for the Kitaev chain with long-range pairing." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF007/document.
Full textIn the first part of the thesis, we propose an exactly-solvable one-dimensional model for fermions with long-range p-wave pairing decaying with distance ℓ as a power law 1/ℓα. We studied the phase diagram by analyzing the critical lines, the decay of correlation functions and the scaling of the von Neumann entropy with the system size. We found two gapped regimes, where correlation functions decay (i) exponentially at short range and algebraically at long range (α > 1), (ii) purely algebraically (α < 1). In the latter the entanglement entropy is found to diverge logarithmically. Most interestingly, along the critical lines, long-range pairing breaks the conformal symmetry for sufficiently small α. This can be detected also via the dynamics of entanglement following a quench. In the second part of the thesis we studied the evolution in time of the entanglement entropy for the Ising model in a transverse field varying linearly in time with different velocities. We found different regimes: an adiabatic one (small velocities) when the system evolves according the instan- taneous ground state; a sudden quench (large velocities) when the system is essentially frozen to its initial state; and an intermediate one, where the entropy starts growing linearly but then displays oscillations (also as a function of the velocity). Finally, we discussed the Kibble-Zurek mechanism for the transition between the paramagnetic and the ordered phase
Vodola, Davide <1986>. "Correlations and Quantum Dynamics of 1D Fermionic Models: New Results for the Kitaev Chain with Long-Range Pairing." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6745/1/vodola_davide_tesi.pdf.
Full textIn the first part of the thesis, we propose an exactly-solvable one-dimensional model for fermions with long-range p-wave pairing decaying with distance as a power law. We studied the phase diagram by analyzing the critical lines, the decay of correlation functions and the scaling of the von Neumann entropy with the system size. We found two gapped regimes, where correlation functions decay (i) exponentially at short range and algebraically at long range, (ii) purely algebraically. In the latter the entanglement entropy is found to diverge logarithmically. Most interestingly, along the critical lines, long-range pairing breaks also the conformal symmetry. This can be detected via the dynamics of entanglement following a quench. In the second part of the thesis we studied the evolution in time of the entanglement entropy for the Ising model in a transverse field varying linearly in time with different velocities. We found different regimes: an adiabatic one (small velocities) when the system evolves according the instantaneous ground state; a sudden quench (large velocities) when the system is essentially frozen to its initial state; and an intermediate one, where the entropy starts growing linearly but then displays oscillations (also as a function of the velocity). Finally, we discussed the Kibble-Zurek mechanism for the transition between the paramagnetic and the ordered phase.
Vodola, Davide <1986>. "Correlations and Quantum Dynamics of 1D Fermionic Models: New Results for the Kitaev Chain with Long-Range Pairing." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6745/.
Full textIn the first part of the thesis, we propose an exactly-solvable one-dimensional model for fermions with long-range p-wave pairing decaying with distance as a power law. We studied the phase diagram by analyzing the critical lines, the decay of correlation functions and the scaling of the von Neumann entropy with the system size. We found two gapped regimes, where correlation functions decay (i) exponentially at short range and algebraically at long range, (ii) purely algebraically. In the latter the entanglement entropy is found to diverge logarithmically. Most interestingly, along the critical lines, long-range pairing breaks also the conformal symmetry. This can be detected via the dynamics of entanglement following a quench. In the second part of the thesis we studied the evolution in time of the entanglement entropy for the Ising model in a transverse field varying linearly in time with different velocities. We found different regimes: an adiabatic one (small velocities) when the system evolves according the instantaneous ground state; a sudden quench (large velocities) when the system is essentially frozen to its initial state; and an intermediate one, where the entropy starts growing linearly but then displays oscillations (also as a function of the velocity). Finally, we discussed the Kibble-Zurek mechanism for the transition between the paramagnetic and the ordered phase.
Karaceper, Maria D. "The Epidemiology and Health System Impact of Medium-Chain Acyl-CoA Dehydrogenase Deficiency Among Affected Children and Those with False Positive Newborn Screening Results in Ontario, Canada." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31509.
Full textBette, Miriam. "Gender Equality Policies: Results for Social Change? : A comparative discourse analysis on gender equality from two ends of the “aid chain”." Thesis, Malmö universitet, Malmö universitetsbibliotek, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-44797.
Full textTavares, Antonio Carlos Sanches. "Influência das iniciativas verdes na cadeia de suprimentos brasileira de embalagens." Universidade Nove de Julho, 2017. http://bibliotecatede.uninove.br/handle/tede/1705.
Full textMade available in DSpace on 2017-08-04T21:46:36Z (GMT). No. of bitstreams: 1 Antonio Carlos Sanches Tavares.pdf: 2287385 bytes, checksum: cf9b93f25f6c9028458bca9468381dda (MD5) Previous issue date: 2017-02-24
The adoption of green initiatives in supply chains is a basic requirement in the relationship between companies, which must take over the principles of environmental management, involving three important focuses: environment, strategy and logistics. Besides, this type of approach also seeks competitive advantages from better integration with the supplier network, greater acceptance of environmentally friendly products and the reduction of costs. The use of packaging is of great importance for society as it plays fundamental roles such as to guarantee the quality of the product and commercialize it. In this set of circumstances, there is also concern about the final destination of the packages and the impacts they cause on the environment. The purpose of this research is to verify if the adoption of green initiatives in the packaging supply chain affects the Environmental, Economic and Operational results of the companies participating in this chain, according to the perception of professionals who work at these companies. The study was conducted through a survey type research for professionals of different hierarchical levels who work at Brazilian industries in the packaging supply chain. It is a quantitative research, the answers were analyzed through statistical techniques. It is important to highlight that this research counts on the institutional support of ABRE - Brazilian Association of Packaging. The results pointed out in general, according to the professionals interviewed, that it is not possible to show that the adoption of green initiatives influence the achievement of Environmental, Economic and Operational results. The only exception found is the Green Purchase Initiative influencing the Environmental Performance of companies in this Supply Chain.
A adoção de iniciativas verdes nas cadeias de suprimentos é requisito básico no relacionamento entre as empresas, as quais devem assumir os princípios da gestão ambiental, envolvendo três focos importantes: meio ambiente, estratégia e logística. Além disso, este tipo de abordagem também visa a vantagens competitivas a partir da melhor integração com a rede de fornecedores, maior aceitação de produtos ecologicamente corretos e redução de custos. O uso das embalagens é de grande importância para a sociedade, pois elas desempenham muitas funções fundamentais tanto para garantir a qualidade do produto quanto para comercializá-lo. Nesse conjunto de circunstâncias, surge também a preocupação com a destinação final das embalagens e com os impactos que elas provocam ao meio ambiente. Por se tratar de um tema com tal relevância e pouco explorado no Brasil, o objetivo desta pesquisa é verificar se, de fato, a adoção das iniciativas verdes na cadeia de suprimentos de embalagens afeta os resultados ambientais, econômicos e operacionais das empresas participantes dessa cadeia, segundo a percepção dos profissionais que nelas atuam. O estudo foi conduzido por meio de uma pesquisa tipo survey, encaminhada para profissionais de diversos níveis hierárquicos que atuam em indústrias brasileiras da cadeia de suprimentos de embalagens. Trata-se de uma pesquisa quantitativa, cujas respostas foram analisadas por meio de técnicas estatísticas. É importante destacar que esta pesquisa conta com o apoio institucional da Associação Brasileira de Embalagens (ABRE). Os resultados apontaram de um modo geral, segundo a visão dos profissionais entrevistados, que não é possível evidenciar que a adoção de iniciativas verdes influencia a obtenção de resultados ambientais, econômicos e operacionais. A única exceção encontrada é a Iniciativa de Compras Verdes influenciando o desempenho ambiental das empresas dessa cadeia de suprimentos.
DE, MARINIS PIETRO. "PARTICIPATORY EVALUATION OF AGRICULTURAL DEVELOPMENT PROGRAMS AS A TOOL FOR IMPROVED SUSTAINABILITY IN DEVELOPMENT COOPERATION." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/703261.
Full textMehdi, Riazi Salman Riazi. "The use of supply chain management to reduce delays as result of pre-construction deficiencies in Malaysian public sector construction projects." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/74750/1/Salman%20Riazi_Mehdi%20Riazi_Thesis.pdf.
Full textFralix, Brian Haskel. "Stability and Non-stationary Characteristics of Queues." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/14569.
Full textJacobsson, Lisa, and Emma Uhrlander. "Mot hållbarhet och cirkuläritet i verksamheter: : En kvalitativ studie om implementering och utveckling av cirkulärekonomiska affärsmodeller i företag." Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-24371.
Full textThis thesis addresses the issue with a consumer society characterized by a linear economy and the negative consequences it entails. In many cases, prosperity is strongly associated to economic growth based on a consumer society. Simultaneously, the economy cannot continue to grow in eternity without harming the environment. In order to solve the paradox, corporations need to be driven in changing to a circular economy. In a circular economy all resources are kept in circulation instead of being consumed and turned into waste. By reusing products, materials and resources the economic value can be maintained. A problem is lack of knowledge in the area, inadequate business models and the fact that corporations do not see the economic benefits of switching to a circular economy. Thus, the purpose with this study is to investigate how corporations within the producing and distributing sector can develop and identify possibilities to improve the transition to a circular economy. This thesis is based on a qualitative method. The literature overview is based on literature in in circular economy and Green Supply Chain Management. Collection of data for the empirical investigation has been collected through in depth interviews together with sales directors and CEOs at three corporations. Further, the collected data has been transcribed and analyzed through a thematic analysis. The relevance of the study has been confirmed by the results. The empirical study clarifies the need demand of distinct directives and guidelines for development and to facilitate the transition towards a circular economy and GSCM. Which is an opinion shared by all respondents who each and every one considers necessary in order to develop and maintain high sustainability standards that permeate the entire value chain. Corporations within the production and distribution sector can improve the conversion process through a break-down-procedure. Through analysis of the implementation process by four smaller phases; drivers, barriers, implementation methods and performances, the transition will be facilitated. Which also enables continuous development and improvements of circular economy models and green supply chains. This study can form the base for future research and development of distinct directives and guidelines for the implementation process and further evolutions of circular economy and GSCM. Identified implementation phases such as drivers, barriers, implementation methods and performance can be used to study further development of the conversion process towards circular economy and GSCM as a part of the business model. An internal perspective on circular economics and GSCM has been the focus for this study, thus proposal for future research could be focused to the subject from an external perspective.
Simmler, Urs. "Mechanism-News in PTC Creo." Universitätsbibliothek Chemnitz, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-141525.
Full textAoulmi, Aïssa. "Contribution à l'étude des propriétés thermodynamiques des hydrocarbures polycycliques, aromatiques et des alcanes à longue chaine." Vandoeuvre-les-Nancy, INPL, 1994. http://www.theses.fr/1994INPL140N.
Full textJonsson, Lovisa, and Linda Larsson. "Framgångsrika logistiska förändringsprinciper i hälso- och sjukvården : En studie över vilka logistiska förändringsmetoder som gett framgångsrikt resultat vid förändringsarbete inom svensk hälso- och sjukvård." Thesis, Linköping University, Department of Management and Engineering, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-9.
Full textHälso- och sjukvården har höga krav som branschen har svårt att uppfylla. Logistik har fått en ökad betydelse inom sektorn och handlar i detta fall om att på kortast tid få en patient färdigbehandlad. Denna rapport tar fram logistiska förändringsprinciper som är framgångsrika i hälso- och sjukvården. En litteraturstudie visar att det finns ett antal logistiska förändringsprinciper och verktyg som med positivt resultat har anpassats till hälso- och sjukvården. Dessa är; Lean production, processorientering, flödesorientering, Time-based competition, Theory of Constraints, Supply chain management, Planering, Mål och mätmetoder, Patienten i fokus, Genombrott och Advanced access. Fallstudier visar att vårdenheter i de flesta fall inte arbetar med specifika förändringsprinciper utan metoder hämtade från flera principer. Många av dessa metoder återkommer i åtskilliga förändringsprinciper och de vanligaste metoderna som identifierats både i litteraturstudien och i fallstudien och därför anses vara framgångsrika är; eliminering av slöseri, standardiseringar, kartläggning av flöde eller process och samverkan inom den egna enheten. Dessa metoder kan härledas till principerna Lean production, processorientering och Genombrott. Viktigt att poängtera är att förändringsprinciperna måste anpassas till den specifika situationen och vårdenheten.
Marchi, Tommaso. "Position and singularity analysis of a class of n-RRR planar parallel robots." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020.
Find full textXavier, Flavia Dias. "Padrão de expressão e significado prognóstico dos genes BCL2, BCL6, CCND2, FN1, LMO2 e SCYA3 pela técnica de PCR em tempo real com linfoma difuso de grandes células B tratado com rituximabe." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5167/tde-24062013-114437/.
Full textIntroduction: Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma; which accounts for almost 50% of the cases at the Hematology Department of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo and Instituto do Câncer do Estado de São Paulo. Its clinical and biological heterogeneity results in more than twenty subtypes according to the World Health Organization classification. Its treatment is based on a combination of anti-CD20 monoclonal antibody and antracycline-based chemotherapy, with a 10-year overall survival of 43.5%. Clinical prognostic determinants such as the International Prognostic Index and the Revised International Prognostic Index lack accuracy, since up to 20% of low-risk patients will die from the disease and up to 60% of high-risk patients will be alive within four years. Such discrepancies can partially be attributed to genetic factors. Diffuse large B-cell lymphoma germinal center gene signature shows superior overall survival compared to activated B-cell signature (76% versus 16%, p=0.01), however microarray gene expression profile is not yet available in clinical practice. Nonetheless, the Mortality Predictor Score for diffuse large B-cell lymphoma based on the prognostic value of BCL2, BCL6, CCND2, FN1, LMO2 and SCYA3 gene expression by quantitative real-time PCR has proved to be independent from the International Prognostic Index in the pre-rituximab era. But it was not significant in high clinical risk patients treated with R-CHOP. The genes BCL2, CCND2 and SCYA3 compose activated B-cell signature, whereas BCL6 and LMO2 compose the germinal center signature and FN1 the lymph-node signature. Objective: Evaluate the impact of BCL2, BCL6, CCND2, FN1, LMO2 and SCYA3 absolute gene expression in Brazilian population diagnosed with diffuse large B-cell lymphoma and treated with R-CHOP, with respect to overall response, disease free survival, progression free survival and overall survival. Methods: Gene expression was analyzed by quantitative real-time PCR of RNA extracted from paraffin-embedded samples of 63 patients, although evaluable in 42. Their values were normalized by endogenous gene ABL and log- transformed on a base 2 scale for subsequent correlation with clinical and outcome variables. Results: With a median follow-up of 29 months, overall survival, disease free survival and progression free survival accounted for 82.8%, 97.14% and 87.53% respectively, while complete response was 82.5%. The expression of LMO2>3logs and BCL6>3.5logs defined a group with higher overall survival (91% versus 64.3%, p=0.040) and progression free survival (95.5% versus 70.7%, p=0.03), independent of International Prognostic Index (p=0.010 and p=0.042) and with significant overexpression of SCYA3 (p=0.046). It was not identified any association between six gene Mortality Predictor Score and prognosis. As a result, we developed the New Genetic Prognostic Score based on the power of concomitant expression of LMO2 and CCND2, defining low-risk (<2.5) and high-risk (>=2.5) groups with distinct overall survival (92.4% versus 57.1%, p=0.011) and progression free survival (96.2% versus 66.7%, p=0.013), independent of International Prognostic Index. Conclusion: In patients with diffuse large B-cell lymphoma treated with R-CHOP, hyperexpression of BCL6, LMO2 and SCYA3 was correlated with a better prognosis. The New Genetic Prognostic Score, defined by LMO2 and CCND2, stratified risk groups with different prognosis, independent of International Prognostic Index
Moreira, Ana Sofia Pereira. "Study of modifications induced by thermal and oxidative treatment in oligo and polysaccharides of coffee by mass spectrometry." Doctoral thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17074.
Full textOs polissacarídeos são os componentes maioritários dos grãos de café verde e torrado e da bebida de café. Os mais abundantes são as galactomananas, seguindo-se as arabinogalactanas. Durante o processo de torra, as galactomananas e arabinogalactanas sofrem modificações estruturais, as quais estão longe de estar completamente elucidadas devido à sua diversidade e à complexidade estrutural dos compostos formados. Durante o processo de torra, as galactomananas e arabinogalactanas reagem com proteínas, ácidos clorogénicos e sacarose, originando compostos castanhos de alto peso molecular contendo nitrogénio, designados de melanoidinas. As melanoidinas do café apresentam diversas atividades biológicas e efeitos benéficos para a saúde. No entanto, a sua estrutura exata e os mecanismos envolvidos na sua formação permanecem desconhecidos, bem como a relação estrutura-atividade biológica. A utilização de sistemas modelo e a análise por espectrometria de massa permitem obter uma visão global e, simultaneamente, detalhada das modificações estruturais nos polissacarídeos do café promovidas pela torra, contribuindo para a elucidação das estruturas e mecanismos de formação das melanoidinas. Com base nesta tese, oligossacarídeos estruturalmente relacionados com a cadeia principal das galactomananas, (β1→4)-Dmanotriose (Man3), e as cadeias laterais das arabinogalactanas, (α1→5)-Larabinotriose (Ara3), isoladamente ou em misturas com ácido 5-Ocafeoilquínico (5-CQA), o ácido clorogénico mais abundante nos grãos de café verde, e péptidos compostos por tirosina e leucina, usados como modelos das proteínas, foram sujeitos a tratamento térmico a seco, mimetizando o processo de torra. A oxidação induzida por radicais hidroxilo (HO•) foi também estudada, uma vez que estes radicais parecem estar envolvidos na modificação dos polissacarídeos durante a torra. A identificação das modificações estruturais induzidas por tratamento térmico e oxidativo dos compostos modelo foi feita por estratégias analíticas baseadas principalmente em espectrometria de massa, mas também em cromatografia líquida. A cromatografia de gás foi usada na análise de açúcares neutros e ligações glicosídicas. Para validar as conclusões obtidas com os compostos modelo, foram também analisadas amostras de polissacarídeos do café obtidas a partir de resíduo de café e café instantâneo. Os resultados obtidos a partir dos oligossacarídeos modelo quando submetidos a tratamento térmico (seco), assim como à oxidação induzida por HO• (em solução), indicam a ocorrência de despolimerização, o que está de acordo com estudos anteriores que reportam a despolimerização das galactomananas e arabinogalactanas do café durante a torra. Foram ainda identificados outros compostos resultantes da quebra do anel de açúcares formados durante o tratamento térmico e oxidativo da Ara3. Por outro lado, o tratamento térmico a seco dos oligossacarídeos modelo (individualmente ou quando misturados) promoveu a formação de oligossacarídeos com um maior grau de polimerização, e também polissacarídeos com novos tipos de ligações glicosídicas, evidenciando a ocorrência de polimerização através reações de transglicosilação não enzimática induzidas por tratamento térmico a seco. As reações de transglicosilação induzidas por tratamento térmico a seco podem ocorrer entre resíduos de açúcares provenientes da mesma origem, mas também de origens diferentes com formação de estruturas híbridas, contendo arabinose e manose como observado nos casos dos compostos modelo usados. Os resultados obtidos a partir de amostras do resíduo de café e de café instantâneo sugerem a presença de polissacarídeos híbridos nestas amostras de café processado, corroborando a ocorrência de transglicosilação durante o processo de torra. Além disso, o estudo de misturas contendo diferentes proporções de cada oligossacarídeo modelo, mimetizando regiões do grão de café com composição distinta em polissacarídeos, sujeitos a diferentes períodos de tratamento térmico, permitiu inferir que diferentes estruturas híbridas e não híbridas podem ser formadas a partir das arabinogalactanas e galactomananas, dependendo da sua distribuição nas paredes celulares do grão e das condições de torra. Estes resultados podem explicar a heterogeneidade de estruturas de melanoidinas formadas durante a torra do café. Os resultados obtidos a partir de misturas modelo contendo um oligossacarídeo (Ara3 ou Man3) e 5-CQA sujeitas a tratamento térmico a seco, assim como de amostras provenientes do resíduo de café, mostraram a formação de compostos híbridos compostos por moléculas de CQA ligadas covalentemente a um número variável de resíduos de açúcar. Além disso, os resultados obtidos a partir da mistura contendo Man3 e 5-CQA mostraram que o CQA atua como catalisador das reações de transglicosilação. Por outro lado, nas misturas modelo contendo um péptido, mesmo contendo também 5-CQA e sujeitas ao mesmo tratamento, observou-se uma diminuição na extensão das reações transglicosilação. Este resultado pode explicar a baixa extensão das reações de transglicosilação não enzimáticas durante a torra nas regiões do grão de café mais ricas em proteínas, apesar dos polissacarídeos serem os componentes maioritários dos grãos de café. A diminuição das reações de transglicosilação na presença de péptidos/proteínas pode dever-se ao facto de os resíduos de açúcares redutores reagirem preferencialmente com os grupos amina de péptidos/proteínas por reação de Maillard, diminuindo o número de resíduos de açúcares redutores disponíveis para as reações de transglicosilação. Além dos compostos já descritos, uma diversidade de outros compostos foram formados a partir dos sistemas modelo, nomeadamente derivados de desidratação formados durante o tratamento térmico a seco. Em conclusão, a tipificação das modificações estruturais promovidas pela torra nos polissacarídeos do café abre o caminho para a compreensão dos mecanismos de formação das melanoidinas e da relação estrutura-atividade destes compostos.
Polysaccharides are the major components of green and roasted coffee beans, and coffee brew. The most abundant ones are galactomannans, followed by arabinogalactans. During the roasting process, galactomannans and arabinogalactans undergo structural modifications that are far to be completely elucidated due to their diversity and complexity of the compounds formed. During the roasting process, galactomannans and arabinogalactans react with proteins, chlorogenic acids, and sucrose, originating high molecular weight brown compounds containing nitrogen, known as melanoidins. Several biological activities and beneficial health effects have been attributed to coffee melanoidins. However, their exact structures and the mechanisms involved in their formation remain unknown, as well as the structure-biological activity relationship. The use of model systems and mass spectrometry analysis allow to obtain an overall view and, simultaneously, detailed, of the structural modifications in coffee polysaccharides promoted by roasting, contributing to the elucidation of the structures and formation mechanisms of melanoidins. Based on this thesis, oligosaccharides structurally related to the backbone of galactomannans, (β1→4)-D-mannotriose, and the side chains of arabinogalactans, (α1→5)-Larabinotriose, alone or in mixtures with 5-O-caffeoylquinic acid, the most abundant chlorogenic acid in green coffee beans, and dipeptides composed by tyrosine and leucine, used as models of proteins, were submitted to dry thermal treatments, mimicking the coffee roasting process. The oxidation induced by hydroxyl radicals (HO•) was also studied, since these radicals seem to be involved in the modification of the polysaccharides during roasting. The identification of the structural modifications induced by thermal and oxidative treatment of the model compounds was performed mostly by mass spectrometry-based analytical strategies, but also using liquid chromatography. Gas chromatography was used in the analysis of neutral sugars and glycosidic linkages. To validate the conclusions achieved with the model compounds, coffee polysaccharide samples obtained from spent coffee grounds and instant coffee were also analysed. The results obtained from the model oligosaccharides when submitted to thermal treatment (dry) or oxidation induced by HO• (in solution) indicate the occurrence of depolymerization, which is in line with previous studies reporting the depolymerization of coffee galactomannans and arabinogalactans during roasting. Compounds resulting from sugar ring cleavage were also formed during thermal treatment and oxidative treatment of Ara3. On the other hand, the dry thermal treatment of the model oligosaccharides (alone or when mixed) promoted the formation of oligosaccharides with a higher degree of polymerization, and also polysaccharides with new type of glycosidic linkages, evidencing the occurrence of polymerization via non-enzymatic transglycosylation reactions induced by dry thermal treatment. The transglycosylation reactions induced by dry thermal treatment can occur between sugar residues from the same origin, but also of different origins, with formation of hybrid structures, containing arabinose and mannose in the case of the model compounds used. The results obtained from spent coffee grounds and instant coffee samples suggest the presence of hybrid polysaccharides in these processed coffee samples, corroborating the occurrence of transglycosylation during the roasting process. Furthermore, the study of mixtures containing different proportions of each model oligosaccharide, mimicking coffee bean regions with distinct polysaccharide composition, subjected to different periods of thermal treatment, allowed to infer that different hybrid and non-hybrid structures may be formed from arabinogalactans and galactomannans, depending on their distribution in the bean cell walls and on roasting conditions. These results may explain the heterogeneity of melanoidins structures formed during coffee roasting. The results obtained from model mixtures containing an oligosaccharide (Ara3 or Man3) and 5-CQA and subjected to dry thermal treatment, as well as samples derived from spent coffee grounds, showed the formation of hybrid compounds composed by CQA molecules covalently linked to a variable number of sugar residues. Moreover, the results obtained from the mixture containing Man3 and 5-CQA showed that CQA acts as catalyst of transglycosylation reactions. On the other hand, in the model mixtures containing a peptide, even if containing 5-CQA and subjected to the same treatment, it was observed a decrease in the extent of transglycosylation reactions. This outcome can explain the low extent of non-enzymatic transglycosylation reactions during roasting in coffee bean regions enriched in proteins, although polysaccharides are the major components of the coffee beans. The decrease of transglycosylation reactions in the presence of peptides/proteins can be related with the preferential reactivity of reducing residues with the amino groups of peptides/proteins by Maillard reaction, decreasing the number of reducing residues available to be directly involved in the transglycosylation reactions. In addition to the compounds already described, a diversity of other compounds were formed from model systems, namely dehydrated derivatives formed during dry thermal treatment. In conclusion, the identification of the structural modifications in coffee polysaccharides promoted by roasting pave the way to the understanding of the mechanisms of formation of melanoidins and structure-activity relationship of these compounds.
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Full text陳玉麒. "SOME RESULTS FOR DELTA-DIFFERENTIAL EQUATIONS ON MEASURE CHAINS." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/18226861776413600932.
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Full textGraduation date: 1995
Hui-chun, Lu, and 呂惠淳. "Research on the Result of Sandwich Teaching Method within the Circulation Management Department in Vocational & Technology Institute – Based on Example of Operations in Living Grocery Stores and Convenience Chain Stores." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/26950627261725153773.
Full text國立彰化師範大學
商業教育學系
92
In spite that the Circulation Industry grows rapidly, this industry is in shortage of human resources and it is difficult to train employees for this industry. Appling the Sandwich-teaching Method suggest a way to solve the lack in human power and develop students' understanding and interests upon the Circulation industry by way of training process. It could also avoid wasting of education resources for later highly staff circulating rate. This research aims to approach the teaching effect of Sandwich-teaching Method in the Circulation Management Departments of Vocational and Technological Colleges and Institutes. The purpose of the research will be stated as follows: 1. To understand the practical models of Sandwich-teaching Method in the Circulation Management Departments 2. To comprehend the necessity, satisfaction degree of implementation and viewpoint of implementation effect toward Sandwich-teaching Method for students, (specialized) teachers and cooperative enterprises in the Circulation Management Departments of Vocational and Technological Colleges and Institutes 3. To recognize the necessity, the satisfaction degree of implementation, and the differences of implementation effects based on the population statistic reference data of three fields (namely: students. Specialized teachers and cooperative enterprises) 4. To realize the necessity, the satisfaction degree of implementation and the differences of implementation effects among the three fields 5. To submit research discoveries and suggestions for schools to improve Sandwich-teaching Method and as a reference data for enterprises to promote human power resources The cooperative objects of the research involve students taking part-time jobs in ordinary grocery stores and convenience chain stores, specialized teachers and enterprises executives. We use questionnaire and face-to-face interviews with the assistance of t test, simple factor variation analysis and IPA as the way for documentary material (data) analysis. The main analytical outcome will be stated as follows: 1. The application models of Sandwich-teaching Method in the Circulation Management Departments of Vocational and Technological Colleges and Institutes will be different due to different schools and different school systems. 2. Students regard the Sandwich-teaching Method highly necessary. Their satisfaction is around medium, while their comments for its effects are between agreeable and normal. Students, with the training period between 1 to 3 years or studying in Fortune Institute of Technology, have higher requirements for the Method. For students, aged under 20, studying, in Fortune Institute of Technology, with the training period under 8 month, or 8 months to 1 year or 1-2 years, have higher satisfaction degree. Male students, aged under 20, with the training period under 8 months, or over 8 months to 1 year or 1-2 years or studying in Jin-Wen Institute of Technology and National Kaohsiung First University of Science and Technology have higher regards to its results. 3. For the necessity of Sandwich-teaching Method, the satisfaction rate of specialized teachers is between satisfied and normal. For the viewpoint of the application effects, it falls between agreeable and normal. While for identification degree of application effects, specialized teachers who have 7-10 year teaching experience or serve in National Kaohsiung First University of Science and Technology have higher identification. 4. The executives of cooperative enterprises consider it (Sandwich-teaching Method) necessary but with normal satisfaction. Executives, aged 31 to 40, have higher requirement while executives with college (or university) diploma feel higher satisfied. 5. The Sandwich-teaching Method which combines the three fields of schools, students and enterprises into one unit enable students to fully learn theory basis and then apply the theories into practical work. 6. For schools, they put their emphasis on learning content and learning outcome. For enterprises, they concern about students' contribution to Sales market. For students, they aim to have higher education. 7. The training and working opportunities after graduation will be the main factors to decide whether Sandwich- teaching Method will succeed to not. 8. Teachers could learn in the chance to visit Circulation Industries, while the enterprises could recommend its experienced executives to lecture in schools so as to fully combine the theory and practical work. We will respectively advance 25 suggestions for the authorities, schools, students and cooperative enterprises according to the outcome of the research in the hope to develop the Sandwich-teaching Method and as a reference data for promoting human resources so as to fulfill the accomplishment of the Sandwich-teaching Method.