Dissertations / Theses on the topic 'Restores human'

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1

Ettabaghi, Achraf. "The importance of medical profession in modern world." Thesis, НТУ "ХПІ", 2016. http://repository.kpi.kharkov.ua/handle/KhPI-Press/22104.

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Christiansen-Weber, Trudy A. "Thymic expression of human wild-type p53 in transgenic mice alters normal thymocyte development and in p53-deficient mice restores radiation-induced apoptosis but fails to prevent thymic lymphoma /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9904824.

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Harkness, Christopher. "Partnerships : an opportunity to restore meaning to the 'human' in human services." University of Western Australia. Social Work and Social Policy Discipline Group, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0069.

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This research study is about partnership working in the human services using community mental health as a context. The purpose of this type of research has relevance today as governments at all levels in Australia are adopting partnerships as social policy tools to address social problems. The rationale for these policies appears to be based on recognition that large social problems require holistic responses through the working together of multiple agencies. However despite the volumes of material about the programmatic means for enacting partnerships I found little which attended to the micro practices of partnership. The lack of guidelines on how to engage in partnership becomes problematic as partnerships in social service contexts have complexities and can be difficult to enact. Moreover actors may feel undermined when it is taken for granted that they have the necessary knowledge and skills to enact partnerships. A case study is conducted on how partnerships are enacted within Bethany Outreach Services, a pseudonym used to represent a psychosocial support service in the Perth metropolitan area. Semi-structured in-depth interviews are conducted with seven participants engaged in a partnership within community mental health. The literature is analysed for its contribution to the critical question of how to “do” partnership. Case examples are utilised to contextualise key principles of partnership. Key elements of theoretical perspectives are applied as a way to better understand how partnerships might work better. Narratives from the literature and the experiences of people as seen through this case study are examined to arrive at some key elements of partnership. Despite their complexities partnerships provide an opportunity for actors to engage their humanity and build relationships based on human qualities such as respect, communication and the sharing of resources. These qualities build social capital, which can be developed in new partnership contexts to address new problem domains. It is through these qualities that partnerships might give meaning to the 'Human' in Human Services.
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O'Callaghan, Katherine Mary. "Incident management: Human factors and minimising mean time to restore service." Thesis, Australian Catholic University, 2010. https://acuresearchbank.acu.edu.au/download/fb06c081cc24ef821d7598da1a07170c4edb5bede27720805c86d7ccc3a073d8/2040776/65038_downloaded_stream_263.pdf.

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Unplanned IT outages can cost businesses money, as well as lost customer satisfaction, and a variety of additional hidden costs. Incident managers are employed by organisations to restore service from unplanned IT outages as expeditiously as possible. This research focused on two components employed by incident managers in doing their job to determine if particular components, or combinations of these components, result in a shorter amount of time to restore service than do others. The components are the characteristics displayed by incident managers and the problem-solving approaches used by incident managers when working to restore service from unplanned IT outages. The characteristics studied were being authoritative, being communicative, being decisive, being demanding, being entrepreneurial, being facilitative and being pragmatic. The two problem-solving approaches used by incident managers and investigated were a solution-focused approach to solving problems and a problem-focused approach to solving problems. The research further determined whether the particular characteristics or problem-solving approaches or combinations of these in a reduction in the amount of time to restore service compared to others.
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Meredith, Neil. "An in-vitro analysis of the stresses in natural and restored human teeth." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286166.

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Mavuso, Thabiso Caesar. "The African Union's right of intervention to restore legitimate order : human protection or regime entrenchment?" Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/37372.

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Nishioka, Hisae. "BMS-708163 and Nilotinib restore synaptic dysfunction in human embryonic stem cell-derived Alzheimer’s disease models." Kyoto University, 2018. http://hdl.handle.net/2433/231014.

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Silva, Márcia Teixeira Desidério da. "Avaliação de metodologias para análise de DNA de amostras de restos mortais e construção de banco de dados de DNA mitocondrial da população do Estado do Rio de Janeiro." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1667.

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A análise do mtDNA vem sendo empregada, recentemente, em Ciência Forense, para identificação de indivíduos e resolução de casos criminais. Também vem sendo utilizada em estudos de genética de populações contribuindo com processos relacionados com o grau de miscigenação dos povos e com a ocupação dos diferentes continentes por populações humanas. O DNA mitocondrial está presente em inúmeras cópias por célula, é de origem materna e não sofre processos de recombinação, o que faz com que essa molécula seja uma poderosa ferramenta nesta área. A análise por mtDNA só é recomendada quando não existe mais fonte de DNA nuclear, ou quando este se encontra altamente degradado, como em amostras forenses. Um dos problemas encontrados é a interferência de artefatos durante as etapas pré e pós sequenciamento, na qual pode se obter uma seqüência de má qualidade. O presente estudo comparou e otimizou dez métodos de purificação de DNA mitocondrial, para amostras de restos mortais e in vivo, nas etapas pré e pós sequenciamento. A metodologia empregada consistiu em extrair o DNA da amostra biológica, amplificar por PCR, seqüenciar as referidas regiões do mtDNA das amostras selecionadas e analisar após eletroforese capilar. A enzima colagenase foi testada com o objetivo de avaliar sua eficiência na etapa de extração do DNA. Interligado a esta etapa, outro objetivo foi avaliar o grau de polimorfismo das regiões HVS-I e HVS-II do mtDNA em amostras da população do estado do Rio de Janeiro como forma de entender o fluxo gênico associado à formação da nossa população. Como conclusão, os melhores métodos de purificação utilizados foram o Centricon, seguido da purificação dos produtos amplificados pela resina da Amershan e dos produtos da reação de sequenciamento pela resina Sephadex. Houve baixa eficiência da enzima colagenase, indicando a presença de possíveis inibidores. Em relação ao banco de dados, foram encontrados 95 polimorfismos distintos na região HVS-I e 52 na região HVS-II. O polimorfismo mais freqüente na região HVS-I foi 16223 (74,5%), enquanto que na região HVS-II foi o 263 (60%). Foram encontrados 92 diferentes haplótipos na região HVS-I e 42 na região HVS-II. Podemos dizer que a população do Estado do Rio de Janeiro, via herança materna, é constituída, em maior parte, pelos africanos (50%), seguidos dos ameríndios (30%) com uma pequena participação dos europeus (21%), demonstrando a grande miscigenação do nosso estado.
Analysis of mtDNA has been employed, recently, in Forensic Science, for identification of peoples and solves criminal cases. So has been used in genetic populations studies and had contributed for understand of process related with degree of mixture people and with occupation of different continents by populations humans. Mitochondrial DNA is present in many copies by cell. It is maternal inheritance and not suffer recombination. So, this cell is powerful tool in this area. Analysis of mitochondrial DNA is recommend when not exist more nuclear DNA or it be degraded as in forensic samples. One of problems find are the artifact encountered during the phases before and after sequencing where can obtained the bad quality sequence. The present study compared and optimized methods of mitochondrial DNA purification to samples human remains and in vivo in phases before and after sequencing. The methodology of analysis by mitochondrial DNA consist in extract it of biological sample, amplify the regions HVS-I and HVS-II of control region, sequence the products amplified and analysis after electroforesis capilar. The colagenase was tested with objective of value its efficiency in phase DNA extraction. In relation that fase, other objective was value the degree polymorphisms in regions HVS-I and HVS-II of mtDNA in samples of population of Rio de Janeiro to contribute for understand of flow genetics associated to formation of our population. As conclusion, the best methods of purification used was Centricon, follow by purification of amplifications products by Amershan and purification od products sequencing by Sephadex. It had fall efficiency of colagenase indicate the presence of probable inhibitors. In relation of data base, was encountered 95 polymorfisms distincts in region HVS-I and 52 in region HVS-II. The polimorfism more often in region HVS-I was 16223 (74,5%), while in region HVS-II was 263 (60%). It was encountered 92 differents haplotypes in region HVS-I and 42 in region HVS-II. It had lower rates of heteroplasmy. We can said that the population of Rio de Janeiro state, by maternal inheritance, was determined, in more portion, by Africans (50%), follow by Amerindians (30%) with small portion of Europeans (21%), showing the bigger miscegenation of our state.
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Briceño, Jesús, and Mario Millones. "Los restos humanos más tempranos del norte del Perú: balance y proyecciones." Pontificia Universidad Católica del Perú, 2012. http://repositorio.pucp.edu.pe/index/handle/123456789/113454.

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The Earliest Human Remains of Northern Perú: Balances and PerspectivesGenerally in American prehistory the very first protagonists have been kept outside of the main discourse. This absence of information is evident if we review the construction of this history and accept that there has been a preconceived pact of indifference towards skeletal remains. The north of Peru is a good example and choice for the objectives of this paper. Given this lack of information, we present our findings about these "lost" bodies in order to finally integrate these data into the study of the earliest people of the Americas.
De manera genérica, la prehistoria americana ha mantenido fuera de su discurso a los restos de sus propios protagonistas. Semejante afirmación adquiere sentido si observamos la confección de esta historia pasada y aceptamos una cierta indiferencia pactada hacia los restos óseos. El norte peruano resulta un buen ejemplo y compromiso de intereses encontrados. Con este trabajo se busca cómo entender esta ausencia, encontrar los cuerpos "ausentes" y finalmente integrarlos al acervo de los materiales de estos primeros grupos humanos.
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10

Carvalho, Fernanda Lourenzo de. "A coleção colonial de restos humanos no MUHNAC: missão antropológica de Moçambique." Master's thesis, Instituto Superior de Ciências Sociais e Políticas, 2019. http://hdl.handle.net/10400.5/19393.

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Dissertação de Mestrado em Antropologia
Baseado na Teoria Crítica e em uma Antropologia de arquivo, este trabalho objetiva (re)apresentar e contextualizar a coleção colonial de restos humanos recolhida pela equipa chefiada por Santos Júnior, Chefe da Missão Antropológica de Moçambique (MAM), que está armazenada no Museu Nacional de História Natural e de Ciência (MUHNAC). Esta investigação desdobra-se, ainda, na identificação do Outro, raça e ciência na Antropologia física realizada na ex-colónia portuguesa, Moçambique, entre os anos de 1936 e 1956; apresenta, também as discussões atuais sobre os museus universais ocidentais que detém coleções coloniais, além de mostrar os argumentos da Nova Museologia e as questões de repatriamento em voga na atualidade. Adiante, contextualiza histórico-socialmente a Antropologia portuguesa no século XX e evidencia o papel da Escola do Porto e de António Mendes Correia na produção e influência da disciplina nas políticas coloniais do Estado. Para finalizar, apresenta o arquivo colonial de Santos Júnior, a coleção colonial de restos humanos, o percurso institucional material e simbólico do espólio e inicia um debate sobre os contextos científico e ético da referida coleção
Based on the Critical Theory and on an archival anthropology, this paper aims to (re) introduce and contextualize the colonial collection of human remains collected by the team headed by Santos Junior, Head of the Anthropological Mission of Mozambique (MAM), which is stored at the National Museum. of Natural History and Science (MUHNAC). This investigation also unfolds in the identification of the Other, race and science in physical anthropology carried out in the former Portuguese colony, Mozambique, between 1936 and 1956; It also presents the current discussions on Western universal museums that hold colonial collections, as well as showing the arguments of the New Museology and the current repatriation issues. Ahead, it contextualizes historically and socially Portuguese anthropology in the twentieth century and highlights the role of the School of Porto and António Mendes Correia in the production and influence of the discipline in the colonial policies of the state. Finally, it presents Santos Júnior's colonial archive, the colonial collection of human remains, the material and symbolic institutional trajectory of the estate and initiates a debate about the ethical and scientific contexts of the collection.
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11

Guimarães, Ana Lucia Nogueira. "Projeto Restaurar: uma forma de inclusão social da criança e do adolescente através da valorização da educação." Faculdades EST, 2013. http://tede.est.edu.br/tede/tde_busca/arquivo.php?codArquivo=475.

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Este trabalho tem como objetivo principal analisar os impactos sociais das ações realizadas pelo Projeto Restaurar Criança Alegre, um dos projetos da Fundação Evangélica Restaurar, mantido pelo Instituto Educacional da Bahia - IEB, e as transformações apresentadas pelas crianças e adolescentes que participam do projeto. Trata-se de um estudo de caso, pesquisa qualitativa, que busca a compreensão de como a educação pode influenciar na formação do sujeito crítico, autônomo, solidário e na mudança de comportamentos e de atitudes. Apresenta o processo educacional e a ação educativa como práticas libertadoras, na compreensão do ser e na busca de alternativas pedagógicas, focadas em processos que vão além de formas acabadas e burocráticas de ensino predefinido, mas que despertem o desejo e o prazer de aprender para ser mais feliz e ter uma vida mais digna. Há décadas a educação vem chamando atenção de debates políticos e sociais na sociedade. Diante das dificuldades vividas pelas crianças do Projeto Restaurar Criança Alegre, como a precarização do ensino, contato com o mundo do crime, uso abusivo de drogas, moradias subdesenvolvidas, mundo globalizado que valoriza o ter e não o ser, falta de emprego, valores e posturas que se modificam e se confrontam com as diferenças de gênero, raça, etnia, desigualdade social, conflitos de gerações, as quais se refletem diretamente no âmbito familiar, escolar e social. A Instituição, no contexto de sua prática transformadora, concebe que todos somos educadores/as e educandos/as, ao mesmo tempo que ensinamos e somos ensinados/as, que a essência fundamental do educador é constituída através de seus atos e de suas interações com o mundo e com os outros. Nesta Instituição, o/a educador/a desenvolve atividades que fomentam o desenvolvimento humano, a participação e a transformação social e que sejam voltadas para uma educação problematizadora, por meio da qual o/a educando/a se desenvolva de forma criativa, crítica, sensível, participando ativamente do processo de construção dos conhecimentos. Os resultados da pesquisa mostram que o desenvolvimento intelectual satisfatório, somado à crença na capacidade do ser e um trabalho com afetividade e compromisso, apontam para a construção do sujeito autônomo, criativo, moral e ético, e estes são valores que poderão ser ensinados e aprendidos.
This paper aims to analyze the social impacts of the actions performed by the Projeto Restaurar Criança Alegre, one of the projects of the Fundação Evangélica Restaurar, supported by the Instituto Educacional da Bahia IEB, and the transformations presented by the children and adolescents that participated of the Project. This is a study case, qualitative research, which seeks to understand how education can influence on the formation of the critical, supportive and autonomous character as well as on the changing of behaviors and attitudes. It presents the educational process and the educative action as liberating practices, on the understanding of the being and in the search of pedagogical alternatives, focused on processes that go beyond the finished and bureaucratic forms of predetermined teaching, but awake the desire and the pleasure of learning to be happier and have a better life. For decades the education has been calling the attention of political and social debates in society. Given the difficulties experienced by children and adolescents of the Projeto Restaurar Criança Alegre, as the precariousness of teaching, contact with the world of crime, drug abuse, underdeveloped homes, globalized world that values the possessions and not the human being, lack of employment, values and attitudes that are changing and confront with the differences of gender, race, ethnicity, social inequality, the generation gap, which directly reflect on the family, school and social ambit. The institution, in the context of its transformative practice, conceives that we are all educators and learners, while we teach and are taught, that the fundamental essence of the educators is constituted through their actions and their interactions with the world and with others. In this institution, the educator develops activities that foster human development, participation and social transformation and that are designed for a problem-based education, through which the educators can develop themselves in a creative, critical and sensitive way, actively participating in the process of construction of knowledge. The results of the research show that the satisfactory intellectual development, coupled with the belief in the capacity of the subject and a work with affectionateness and commitment, point to the construction of an autonomous, creative, moral and ethical subject and these are values that could be taught and learned.
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López-Polín, D'Olhaberriague Lucía. "Metodología y criterios de restauración de restos óseos pleistocenos. El tratamiento de los fósiles humanos de TD6 (Gran Dolina, Sierra de Atapuerca)." Doctoral thesis, Universitat Rovira i Virgili, 2016. http://hdl.handle.net/10803/386402.

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Aquesta tesi doctoral pretén proporcionar criteris per a realitzar intervencions de conservació-restauració (o preparació) en restes òssies plistocenes, sobre les quals es realitzen estudis des d'una doble perspectiva: l'arqueològica i la paleontològica. Dins d'aquests dos camps, hi ha diversos estudis que poden veure's beneficiats en major o menor mesura en funció del tipus i el nivell de restauració que s'apliqui als fòssils (grau de neteja, de reconstrucció, etc). El treball es basa en la restauració de fòssils d’Homo antecessor procedents del nivell TD6 de Gran Dolina (Sierra de Atapuerca, Burgos). Aquests fòssils presenten problemes comuns a molts altres jaciments, especialment de mitjà càrstic: el sediment amb freqüència és compacte i està fortament adherit a la superfície òssia. En conseqüència, part del treball consisteix a esmenar fractures d'excavació i a “acabar d'excavar” els fòssils al laboratori. La Conservació i Restauració té els seus propis principis i mètodes. Les intervencions es basen en el coneixement tant dels fòssils com de les tècniques i productes de restauració. A més, sempre es dissenyen a partir del diagnòstic de les alteracions i dels objectius fixats abans de la intervenció. En aquesta tesi, es proposa que els requeriments dels diferents estudis realitzats sobre fòssils han de servir com a pautes per a fixar els objectius i els graus d'intervenció. Queda molt treball de recerca per desenvolupar, ja que encara cal incrementar el encara insuficient corpus sobre restauració de restes òssies, sobre les tècniques i els criteris específics d'actuació. En aquesta tesi s'inclouen algunes publicacions les quals tenen per objectiu començar a cobrir aquest buit.
Esta tesis doctoral pretende proporcionar criterios para realizar intervenciones de conservación-restauración (o preparación) en restos óseos pleistocenos, sobre los cuales se realizan estudios desde una doble perspectiva, la arqueológica y la paleontológica. Dentro de estos dos campos, hay diversos estudios que pueden verse beneficiados en mayor o menor medida en función del tipo y del nivel de restauración que se aplique a los fósiles (grado de limpieza, de reconstrucción, etc). El trabajo se basa en la restauración de fósiles de Homo antecessor procedentes del nivel TD6 de Gran Dolina (Sierra de Atapuerca, Burgos). Estos fósiles presentan problemas comunes a otros muchos yacimientos, especialmente de medio kárstico: el sedimento con frecuencia es compacto y está fuertemente adherido a la superficie ósea. En consecuencia, parte del trabajo consiste en subsanar fracturas de excavación y en “terminar de excavar” los fósiles en el laboratorio. La Conservación y Restauración tiene sus propios principios y métodos. Las intervenciones se basan en el conocimiento tanto de los fósiles como de las técnicas y productos de restauración. Además, siempre se diseñan a partir del diagnóstico de las alteraciones y de unos los objetivos fijados antes de la intervención. En esta tesis se propone que los requerimientos de los distintos estudios realizados sobre fósiles, pueden servir como como pautas para fijar los objetivos y los grados de intervención. Queda mucho trabajo de investigación por desarrollar, ya que aún hay que incrementar el aún insuficiente el corpus sobre restauración de restos óseos, sobre las técnicas y los criterios específicos de actuación. En esta tesis se incluyen algunas publicaciones cuyo objetivo es empezar a cubrir este hueco.
This doctoral thesis aims to provide criteria for conservation-restoration interventions (or preparation) of Pleistocene bones, which may be studied from either archaeological or paleontological perspective. Within these two fields, there are several studies that can benefit to a greater or lesser extent depending on the type and level of treatment of the fossil (degree of cleaning, reconstruction, etc.). The work is based on the preparation of Homo antecessor fossils from TD6 unit of Gran Dolina (Atapuerca, Burgos). These fossils have common problems to many other sites, particularly other karstic sites: the sediment is frequently compact and strongly adhered to the bone surface. Consequently, part of the preparation work involves adheriing fragments and `finishing digging´ in the laboratory. Conservation is a discipline that has its own principles and methods. Treatments are based on knowledge of either the fossils and the products and techniques for conservation. Treatments are always designed after the diagnosis of alterations and considering the objectives before the intervention. This thesis proposes that the requirements of the different studies of fossils can serve as guidelines for setting objectives and degrees of intervention. There is much research to develop in order to increase the still insufficient corpus on conservation or preparation of bones, both on the techniques and also on specific criteria. This thesis it includes some publications aimed to start to cover this gap.
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Ribeiro, Alexandre Caiafa. "Utilização de sistema multiplex de marcadores do tipo INDELs em identificação humana por DNA." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4660.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Os INDELs são polimorfismos de comprimento, gerados a partir de inserções e/ou deleções de um ou mais nucleotídeos. Os marcadores INDELs, que estão amplamente distribuídos pelo genoma e se caracterizam pela alta estabilidade devido à baixa taxa mutacional (10-9), podem ser analisados a partir da amplificação por PCR (Reação em Cadeia da Polimerase). A facilidade de análise e a possibilidade de construção de sistemas multiplex capazes de gerar amplicons curtos (menores que 100 pb) tornam os INDELs uma importante ferramenta para identificação humana por DNA. Para avaliar a eficiência e validar a metodologia que emprega os polimorfismos de inserção/deleção na identificação humana, utilizamos o sistema Indel-plex ID, capaz de amplificar simultaneamente 38 loci INDELs bialélicos de cromossomos autossomos. Diferentes amostras biológicas (cabelo, saliva, sangue, sêmen e urina) foram genotipadas apresentando reprodutibilidade entre todas as tipagens. A concentração mínima de DNA necessária para amplificação dos 38 loci INDELs foi de 0,5 ng. Artefatos do tipo split peaks foram observados em algumas amostras. Os produtos da PCR foram purificados em resina Sephadex proporcionando melhores condições de análise, redução de artefatos e aumento na intensidade média de fluorescência dos alelos amplificados. A eficiência do sistema Indel-plex ID na amplificação de DNA degradado foi verificada durante as análises das amostras de DNA extraídas de restos mortais (ossos e dentes). Comparativamente ao sistema Identifiler, o Indel-plex ID, se mostrou mais eficiente em termos de número de loci genotipados e qualidade de amplificação. Nas investigações de vínculos genéticos realizadas com o sistema Indel-plex ID foi possível corroborar resultados anteriores obtidos pela análise de marcadores STR. Nas análises com amostras in vivo foram obtidos valores máximos de Probabilidades de Paternidade de 99,99998%. Para casos envolvendo supostos pais falecidos, o sistema Indel-plex ID reforçou resultados obtidos com o sistema Identifiler e Minifiler. A Probabilidade de Paternidade de 99,953%, obtida com o sistema Indel-plex ID, conjugada com a Probabilidade de Paternidade de 99,957%, obtida como o sistema Minifiler, possibilitou um índice final de 99,99998%. Os resultados evidenciaram que os loci INDELs do sistema Indel-plex ID são altamente informativos, constituindo uma ferramenta importante em estudos de identificação humana e de relações de parentesco
INDELs are length polymorphisms, generated from insertions and/or deletions of one or more nucleotides. The INDEL markers, which are widely distributed throughout the genome and characterized by high stability due to their low mutational rate (10-9), can be analyzed based on amplification by PCR (Polimerase Chain Reaction). This ease in being analyzed and the possibility of building multiplex systems capable of generating short amplicons (smaller than 100 pb), render INDELs an important tool for DNA-based human identification. So as to evaluate the efficiency and validate the methodology which makes use of insertion/deletion polymorphisms in human identification, we have employed the Indel-plex ID system, capable of simultaneously amplifying 38 INDEL loci of biallelic autosome chromosomes. Different biological samples (hair, saliva, blood, semen and urine) were genotyped showing reproducibility of all typing. The minimum DNA concentration for the amplification of the 38 INDEL loci is 0,5 ng. Artifacts of the split peaks type were observed in some samples. The purification of the PCRs products in Sephadex resin provided better conditions for analysis, reduction of artifacts and increased the average intensity of allele fluorescence. The efficiency of the Indel-plex ID system in the amplification of degraded DNA was verified in analysis of DNA samples extracted from mortal remains (bones and teeth). In comparison with the Identifiler system, the Indel-plex ID has proven more efficient in terms of the number of genotyped loci and amplification quality. During the investigation of genetic relations, carried out with the Indel-plex ID system, it was possible to corroborate previous results obtained through the analysis of STR markers. In investigations based on in vitro samples, maximum values of 99,99998% in Paternity Probabilities were obtained. In genetic investigations related to deceased supposed parents, the Indel-plex ID system corroborated results obtained with the Identifiler and Minifiler systems. The Paternity Probability of 99,953% obtained with the Indel-plex ID system, allied with the Paternity Probability of 99,957% obtained with the Minifiler rendered possible the final indicator of 99,99998%. The results have made evident that the INDEL loci of the Indel-plex ID system are highly informative and constitute an important tool for studies in both human identification and parenthood relations identification
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Martínez, Pérez-Pérez Alejandro. "Evolución de la dieta en Cataluña y Baleares desde el Paleolítico hasta la Edad Media a partir de restos esqueléticos." Doctoral thesis, Universitat de Barcelona, 1990. http://hdl.handle.net/10803/810.

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El estudio de las poblaciones humanas pretéritas no se limita actualmente a una descripción morfológica y tipológica clásicas. El desarrollo de nuevas técnicas de análisis nos permite abordar cuestiones sobre adaptación y calidad de vida. Las sociedades humanas se caracterizan especialmente por su capacidad de moldear el ambiente explotándolo según las necesidades y amortiguando su efecto selectivo. En ese contexto la Cultura aparece como un sistema adaptativo, frente a condiciones adversas, que se desarrolla de forma paralela al cambio morfológico que acompaña al proceso evolutivo humano. El grado de adaptación frente al ambiente, tanto biológico como cultural, va asociado a la evolución morfológica y nos informa sobre las condiciones de vida de las poblaciones humanas en los diferentes momentos de su evolución.

El objetivo de la presente Memoria Doctoral es estudiar la dieta con el fin de profundizar en un aspecto adaptativo concreto de las poblaciones humanas que nos informe sobre su interacción con el medio. Al hablar de dieta nos referimos a la caracterización de los alimentos que son ingeridos por una persona o un colectivo. De entre todos los alimentos susceptibles de ser utilizados, el ser humano selecciona para su dieta aquellos que por su capacidad nutritiva sean más adecuados desde el punto de vista adaptativo.

Son muy variadas, sin embargo, las causas que llevan a seleccionar un determinado alimento. De ese conjunto de factores depende el que la dieta ingerida esté asociada a una nutrición adecuada, aunque la asimilación y aprovechamiento de los alimentos ingeridos depende no sólo de la dieta sino también de otros aspectos (patológicos, adaptativos, etc.)

Desde el origen de la cultura humana y a medida que esta adquiere una mayor complejidad, la dieta determina de forma creciente el patrón económico de las sociedades humanas. Una gran parte de su estructura social está definida por los mecanismos de obtención y procesamiento de los aumentos. Dieta y patrón económico serán, pues, conceptos muy próximos que nos permitirán establecer una relación directa entre adaptación biológica y cultura humana.

Al enfocar el estudio de las poblaciones humanas desde un punto de vista paleonutricional tenemos que tener en cuenta tres aspectos: 1) la estrategia alimentaria, 2) el grado de adaptación paleoambiental mediante el estudio de indicadores paleonutrientes y 3) la explotación de recursos alimentarios. Son factores no necesariamente correlacionados pero sí complementarios. No existen sistemas de organización social o de explotación de recursos que sean por definición más o menos adaptatívos. Su eficacia viene dada por la presión selectiva del ambiente y el grado de respuesta adaptativa, tanto biológica como cultural de las poblaciones.

Nuestro objetivo es doble. Por un lado, plantearemos la utilización de nuevas técnicas de estudio paleonutricional señalando sus ventajas y advirtiendo de las precauciones necesarias al enfocar un estudio como el que nos ocupa. Y por otro, intentaremos caracterizar la dieta de las poblaciones humanas que estudiaremos, a través del tiempo. Por ello, de los tres aspectos señalados anteriormente nos interesa principalmente la caracterización de la dieta en función de la preponderancia de la explotación de uno u otro tipo de recurso alimentario.
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15

Almeida, Thaís Vaz Sampaio de. "A respeito dos mortos: remanescentes humanos do Max e suas implicações éticas." Pós-Graduação em Arqueologia, 2018. http://ri.ufs.br/jspui/handle/riufs/9483.

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Human bone remnants have always aroused a great deal of interest from the academic community and the community at large, above all by the possibility of access to the information inherent to the already extinct populations. Such information brings great enrichment to several areas of knowledge, especially Archeology, since they allow the systematic study of biological, social and cultural factors, among other aspects of these human groups. However, for the most part, this type of vestige is still regarded as a mere object in the service of science. This dissertation seeks to explore this theme, presenting ethical reflections in the proceeding with osteological collections of archaeological origin and brings our attention to the proposed case study: the collection of burials from the Museu de Arqueologia de Xingó, Canindé de São Francisco, SE. In addition to the ethical analysis that permeates the treatment of these traces, we propose a new approach for a sample of this collection, composed of 88 individuals buried that were under surveillance of the Bioarchaeology Laboratory of the Federal University of Sergipe, in Laranjeiras, always seeking to arouse respect for the individuals worked and guided by the notions of conservation and documentation inherent in the area of Museology, the work throws new glances for the conditions of these collections and proposes an interdisciplinarity between this and Archeology. Such interaction will bring great benefits in respect to the memory of human groups, while it will contribute to the sedimentation of reflections about the notions of belonging to these individuals, contributing to the legal delineations of the theme.
Os remanescentes ósseos humanos sempre suscitaram um grande interesse da comunidade acadêmica e da comunidade em geral, sobretudo pela possibilidade de acesso às informações inerentes às populações já extintas. Tais informações trazem grande enriquecimento para diversas áreas do conhecimento, com destaque para a Arqueologia, uma vez que permitem o estudo sistemático acerca dos fatores biológicos, sociais, culturais, dentre outros aspectos destes grupos humanos. Entretanto, em sua maioria, este tipo de vestígio é encarado ainda como mero objeto a serviço da ciência. Esta dissertação busca explorar esta temática, apresentando reflexões de cunho ético no proceder com coleções osteológicas de origem arqueológica e traz nossas atenções ao estudo de caso proposto: a coleção de sepultamentos do Museu de Arqueologia de Xingó, em Canindé de São Francisco, SE. Além da análise ética que permeia o tratamento destes vestígios, propomos uma nova abordagem para uma amostra desta coleção, composta de 88 indivíduos sepultados e que estavam sob a guarda do Laboratório de Bioarqueologia da Universidade Federal de Sergipe, em Laranjeiras, sempre buscando suscitar o respeito pelos indivíduos trabalhados e balizado pelas noções de conservação e documentação inerentes à área da Museologia, o trabalho lança novos olhares para as condições destes acervos e propõe uma interdisciplinaridade entre esta e a Arqueologia. Tal interação trará grandes benefícios no que tange o respeito à memória dos grupos humanos, ao passo que contribuirá para a sedimentação das reflexões acerca das noções de pertencimento para com estes indivíduos, contribuindo para os delineamentos legais da temática.
Laranjeiras
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16

Kaulicke, Peter, Lars Fehren-Schmitz, María Kolp-Godoy, Patricia Landa, Óscar Loyola, Martha Palma, Elsa Tomasto, Cindy Vergel, and Burkhard Vogt. "Relevance of a Burial Area from the Late Formative in the Ica Department, Southern Perú." Pontificia Universidad Católica del Perú, 2012. http://repositorio.pucp.edu.pe/index/handle/123456789/113401.

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The burial area BRiG 3117 (Coyungo) was investigated during the PABRiG (Proyecto Arqueológico Bajo Río Grande). It consists of four burial contexts with about 25 individuals (MNI) and a considerable amount of pottery, textiles and gourd fragments among others. One of the textiles is part of a famous piece housed at Dumbarton Oaks. It is the most significant and complex compound known from the south coast during Late Formative times despite its heavy previous looting. In this paper the material evidence is presented in a preliminary form and some concerning interpretations are offered.
El área funeraria BRiG 3117 (Coyungo) fue investigada en el marco del Proyecto Arqueológico Bajo Río Grande de Nazca. Se trata de un conjunto de cuatro contextos funerarios con unos 25 individuos (NMI) y una cantidad elevada de restos de cerámica, textiles, mates y otros. Uno de los fragmentos pertenece a una famosa pieza de la colección de Dumbarton Oaks. Es el conjunto más complejo y significativo del Periodo Formativo Tardío de la costa sur conocido hasta la fecha, pese a que estaba saqueado. En este trabajo se presentan las evidencias en forma preliminar y se ofrecen algunas interpretaciones al respecto.
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17

Witthuhn, Lucille. "Reconnect, restore, regenerate : creating restorative environments by regenerating the human-nature connection." Diss., 2013. http://hdl.handle.net/2263/32790.

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The dissertation investigates how non-profit organisations (NPOs) can function more efficiently by sharing resources and services. The design responds with the strategy of service integration, by transforming the facilities of POPUP, a single NPO, into a shared services hub for multiple NPOs. POPUP is a People Upliftment Programme in Salvokop, Pretoria, and serves the under-privileged communities of Pretoria with skills development courses. The dissertation aims to create restorative environments for these students and explores the theoretical approaches of regenerative design, biophilic design and restorative environmental design. The premise of the investigation is that humanity has an inherent inclination towards nature and that a healthy human-nature connection enables the healing process. Furthermore, the dissertation follows a contextual approach that responds to the railway heritage significance of Salvokop, the urban condition of disconnection from the Central Business District, as well as the self-restoration of the natural landscape. The study seeks to regenerate the human-nature connection, a manifestation of the connection between the current natural landscape and the urban condition. In this way, restorative environments are created that contribute to the regeneration of people.
Dissertation MArch(Prof)--University of Pretoria, 2014
Architecture
MArch(Prof)
Unrestricted
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18

Castellano-Pellicena, Irene, N. E. Uzunbajakava, Charles Mignon, B. Raafs, Vladimir A. Botchkarev, and M. Julie Thornton. "Does blue light restore human epidermal barrier function via activation of Opsin during cutaneous wound healing?" 2018. http://hdl.handle.net/10454/16624.

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Yes
Background and Objective Visible light has beneficial effects on cutaneous wound healing, but the role of potential photoreceptors in human skin is unknown. In addition, inconsistency in the parameters of blue and red light‐based therapies for skin conditions makes interpretation difficult. Red light can activate cytochrome c oxidase and has been proposed as a wound healing therapy. UV‐blue light can activate Opsin 1‐SW, Opsin 2, Opsin 3, Opsin 4, and Opsin 5 receptors, triggering biological responses, but their role in human skin physiology is unclear. Materials and Methods Localization of Opsins was analyzed in situ in human skin derived from face and abdomen by immunohistochemistry. An ex vivo human skin wound healing model was established and expression of Opsins confirmed by immunohistochemistry. The rate of wound closure was quantitated after irradiation with blue and red light and mRNA was extracted from the regenerating epithelial tongue by laser micro‐dissection to detect changes in Opsin 3 (OPN3) expression. Retention of the expression of Opsins in primary cultures of human epidermal keratinocytes and dermal fibroblasts was confirmed by qRT‐PCR and immunocytochemistry. Modulation of metabolic activity by visible light was studied. Furthermore, migration in a scratch‐wound assay, DNA synthesis and differentiation of epidermal keratinocytes was established following irradiation with blue light. A role for OPN3 in keratinocytes was investigated by gene silencing. Results Opsin receptors (OPN1‐SW, 3 and 5) were similarly localized in the epidermis of human facial and abdominal skin in situ. Corresponding expression was confirmed in the regenerating epithelial tongue of ex vivo wounds after 2 days in culture, and irradiation with blue light stimulated wound closure, with a corresponding increase in OPN3 expression. Expression of Opsins was retained in primary cultures of epidermal keratinocytes and dermal fibroblasts. Both blue and red light stimulated the metabolic activity of cultured keratinocytes. Low levels of blue light reduced DNA synthesis and stimulated differentiation of keratinocytes. While low levels of blue light did not alter keratinocyte migration in a scratch wound assay, higher levels inhibited migration. Gene silencing of OPN3 in keratinocytes was effective (87% reduction). The rate of DNA synthesis in OPN3 knockdown keratinocytes did not change following irradiation with blue light, however, the level of differentiation was decreased. Conclusions Opsins are expressed in the epidermis and dermis of human skin and in the newly regenerating epidermis following wounding. An increase in OPN3 expression in the epithelial tongue may be a potential mechanism for the stimulation of wound closure by blue light. Since keratinocytes and fibroblasts retain their expression of Opsins in culture, they provide a good model to investigate the mechanism of blue light in wound healing responses. Knockdown of OPN3 led to a reduction in early differentiation of keratinocytes following irradiation with blue light, suggesting OPN3 is required for restoration of the barrier function. Understanding the function and relationship of different photoreceptors and their response to specific light parameters will lead to the development of reliable light‐based therapies for cutaneous wound healing.
European Commission 7th Framework Programme for Research and Technical Development - Marie Curie Innovative Training Networks (ITN), Grant agreement no.: 607886
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19

Garino, Tamara. "Complexities and responsibilities in the management and exhibition of human remains in Western museums. The Italian case." Master's thesis, 2019. http://hdl.handle.net/10316/93398.

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Dissertação de Mestrado em Património Cultural e Museologia apresentada à Faculdade de Letras
Nas últimas décadas o tema da retenção, do estudo e da exposição de restos humanos junto do público tem vindo a adquirir uma importância cada vez maior nas instituições museológicas ocidentais. A origem humana dos restos humanos impõe hoje em dia um tratamento mais sensível e respeitoso desses materiais, que não podem ser considerados meramente objetos ou artefatos, mas como vestígios de pessoas que um dia viveram e que, como tal, merecem uma atenção ética específica nos seus tratamento e exposição.Este trabalho investiga as principais complexidades levantadas pela gestão e pela exposição de restos antropológicos nas instituições curatoriais ocidentais e explora os principais elementos de controvérsia que os tornaram hoje objetos de luta política. À luz das complexidades associadas a esses achados, são apresentadas, também, as responsabilidades dos profissionais do museu, investigadores e decisores políticos que precisam lidar com seus estudos, conservação e exibição.Através de uma análise bibliográfica, da participação em conferências e do diálogo direto com conservadores, curadores e trabalhadores de museus tem sido possível destacar as principais dificuldades teóricas e práticas em trabalhar com esse património, tão importante do ponto de vista histórico, científico e cultural, mas também extremamente sensível e difícil de gerir.Partindo de uma contextualização internacional do problema, este trabalho foca principalmente o caso italiano, onde a falta de uma estrutura legislativa que defina e regule o tratamento desse património e uma falta generalizada de recursos económicos dificulta muito a obtenção de uma gestão e promoção correta do mesmo.Através da apresentação do caso de estudo do Museu Egípcio de Turim, demonstramos a importância de uma mudança de atitude do museu contemporâneo: não apenas em relação ao património que ele preserva, mas também no sentido das comunidades que o museu representa bem como daqueles que o visitam. Com esse objetivo, foi elaborado um estudo para visitantes do museu, para avaliar a percepção pública perante a exibição de restos humanos antigos no Museu Egípcio de Turim.A análise apresentada neste trabalho mostrou ainda a impossibilidade de criar uma solução universalmente válida aplicável às diferentes situações do museu e aos diferentes tipos de artefatos humanos preservados. Surgiu claramente, no entanto, a necessidade de repensar a atitude do museu em relação a restos humanos, às comunidades de origem destes e ao público em geral.
The issue related to the retention, study and exhibition of human remains acquired in the last decades an increasingly importance within the Western museum institutions. The human nature of human remains imposes nowadays a more sensitive and respectful treatment of these materials, which cannot be merely considered as objects or artifacts, but rather as once living people who, as such, deserve a particular ethical attention to their treatment and exhibition.This research investigates the main complexities raised by the management and the public display of anthropological finds within Western curatorial institutions and explores the main elements of controversy that have made them today objects of political struggle. In the light of the complexities associated with these finds, are presented, then, also the responsibilities of the museum professionals, scholars, and policy-makers who have to deal with their study, conservation and exhibition.Through a careful bibliographic analysis, participation in conferences and direct dialogue with conservators, curators and museum workers has been possible to highlight the main theoretical and practical difficulties of working with this heritage, so important from an historical, scientific and cultural point of view, but also extremely sensitive and difficult to manage.Starting from an international contextualization of the problem, this work finally focuses on the Italian case, where the lack of a legislative framework that defines and regulates the treatment of this heritage and a widespread lack of economic resources, makes very difficult to achieve a correct management and promotion of it.Through the presentation of the case study of the Egyptian Museum of Turin, we have demonstrated the importance of a change in the attitude of the contemporary museum: not only towards the heritage it preserves, but also toward the communities that it represents within it and those that visit it. With this purpose has been draft a museum visitor study aimed at evaluating the public perception of ancient human remains exhibited within the Egyptian Museum of Turin.The analysis carried out in this work has finally shown the impossibility of having a universally valid solution applicable to the different museum situations and to the different types of human artifacts preserved. Nevertheless, has clearly emerged the need for a rethinking of the museum's attitude towards the finds themselves, the communities of origin and the general public.
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