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Journal articles on the topic 'Respiratory investigations'

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Author: Grafiati

Published: 10 December 2022

Last updated: 29 January 2023

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1

Qüdrət qızı Orucova, Elza, Lalə İslah qızı Rüstəmova, Adilə Novruz qızı Ələsgərova, Gülnarə Aydın qızı Kərimova, and Fəridə Hafiz qızı Heydərova. "To study of antiviral activity of artemicia L. etheric oil in experimental model." SCIENTIFIC WORK 75, no. 2 (February 18, 2022): 133–38. http://dx.doi.org/10.36719/2663-4619/75/133-138.

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Kəskin respirator virus infeksiyalarında terapevtik məqsədlər üçün bitki mənşəli yeni dərman vasitələrinin aparılması eksperimental təbabətin əsas istiqamətlərindən biridir. Bu tədqiqatın məqsədi eksperimental modeldə Artemicia L. efir yağının antiviral fəaliyyətini öyrənməkdir. Bu məqsədlə immunxromatoqrafiya üsulu ilə kəskin respirator infeksiya şübhəsi olan 202 xəstənin burun və burun-udlağın yaxmalarında bəzi respirator viruslar aşkar edilib. Tədqiqatların nəticələri göstərir ki, 2018-2019-cu illərdə Bakı şəhərində kəskin respirator virus infeksiyalarının törədicilərinin etioloji strukturlarında qopma tezliyindən asılı olaraq respirator sinsisial virus və respirator adenovirus üstünlük təşkil etmişdir (2,3%). Artemicia İssayevi Rzazade efir yağının antiviral aktivliyi 50-75%, Malabalia efir yağının antiviral aktivliyi təxminən 25% təşkil edir. Açar sözlər: kəskin respirator virus infeksiyaları, Artemisia L., Yovşan cinsi, Artemisia issayevi Rzazade, efir yağı,antivirus fəallıq, in vitro, immunxromatoqrafiya Elza Gudrat Orujova Lala Islah Rustamova Adila Novruz Alasgarova Gulnara Aydin Karimova Farida Hafiz Heydarova To study of antiviral activity of artemicia L. etheric oil in experimental model Summary The carrying out the new drug means of plant origin for terapeutical purpose in acute respiratory viral infections is an detual direction of experimental medicine. The aim of present investigation is to study of antiviral activity of Artemicia L. etheric oil in experimental model. For this purpose the nasal and nasopharyngeal smears of 202 patiens with suspicion for acute respiratory infection have been observed for some respiratory viruses by using the immunchromatography method. The results of investigations showes that in the etiological structures of agents of acute respiratory viral infections in Baku city during 2018-2019 years from depending of appedring frequency the respiratory sinsitsial virus and respiratory adenovirus have been dominate (2,3%). The antivirul activity of Artemicia issayevi Rzazade etheric oil was 50-75%, the antiviral activity of Malabalia etheric oil consist about 25%. Key words: the acute respiratory viral infections, Artemisia L., Artemisia issayevi Rzazade, etheric oil, antiviral activity, in vitro, immunochromatography

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Ivanova, L. A., M. N. Gorizontova, Yu V. Statsenko, I. V. Babenko, G. M. Vologzhanina, and O. V. Krupenina. "Complex laboratory investigations in occupational respiratory diseases." PULMONOLOGIYA, no. 4 (August 28, 2008): 26–30. http://dx.doi.org/10.18093/0869-0189-2008-0-4-26-30.

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Results of complex laboratory examination of 103 patients with dust related bronchitis caused by exposure of various industrial dusts, 22 patients with pneumoconiosis and 12 subjects not having respiratory pathology and not exposed to quartz dust or any other occupational hazards are presented in this article. Laboratory examination included morphological investigations of sputum and bronchial brush biopsy specimens, cytochemical characterization of bronchial ciliated epithelium and blood cells, and bacteriological and serological investigations of bronchial mucus. Our results demonstrated that morphological lesions of bronchial epithelium cells leading to their death followed cell dysfunction, disorders of enzyme activity, hypoxemia, predominance of Haemophilus influenzae in microflora, and significant inflammatory and allergic response in blood. These changes were found in different clinical stages of dust related bronchitis and pneumoconiosis. The findings obtained are of great importance for understanding pathogenic mechanisms of dust related lung diseases as well as from clinical point of view such as diagnosis and development of individual treatment strategies.

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LÖFSTRÖM, GUNNAR. "Investigations into Acute Infections of the Respiratory Tract." Acta Medica Scandinavica 130, no. 2 (April 24, 2009): 132–39. http://dx.doi.org/10.1111/j.0954-6820.1948.tb10050.x.

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4

Vries, E. de. "Immunological investigations in children with recurrent respiratory infections." Paediatric Respiratory Reviews 2, no. 1 (March 2001): 32–36. http://dx.doi.org/10.1053/prrv.2000.0099.

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5

Rustin, P., D. Chretien, T. Bourgeron, B. Gérard, A. Rötig, J. M. Saudubray, and A. Munnich. "Biochemical and molecular investigations in respiratory chain deficiencies." Clinica Chimica Acta 228, no. 1 (July 1994): 35–51. http://dx.doi.org/10.1016/0009-8981(94)90055-8.

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6

Ashrafizadeh, Amir, Shreya Mehta, Christopher B. Nahm, Matthew Doane, Jaswinder S. Samra, and Anubhav Mittal. "Preoperative cardiac and respiratory investigations do not predict cardio‐respiratory complications after pancreatectomy." ANZ Journal of Surgery 90, no. 1-2 (October 17, 2019): 97–102. http://dx.doi.org/10.1111/ans.15515.

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7

Sarkar, Shatanik, Chaitali Patra, Shibani Pal, and Arkapriya Pramanik. "Recurrent Respiratory Tract Infection in an infant: Early Diagnosis by Clinical and Radiological Pearls." Journal of Nepal Paediatric Society 41, no. 1 (April 24, 2021): 111–14. http://dx.doi.org/10.3126/jnps.v41i1.30250.

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Recurrent respiratory tract infections, a cause of concern for both parents and paediatricians, can have various etiologies entitled to different organ systems. Diagnosing the exact cause warrants both clinical acumen and timely investigations. Here, we are reporting an infant with recurrent respiratory tract infections, where adequate clinical examination prompted us to diagnose the extra-respiratory cause with simple investigations.

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8

Sharma, C., V. Nehra, D. Lather, Rajesh, A. Kumar, and G. Narang. "Investigations on respiratory affections in adult cattle in Haryana." Indian Journal of Veterinary Pathology 45, no. 2 (2021): 89–97. http://dx.doi.org/10.5958/0973-970x.2021.00017.1.

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9

Gillespie, S. H., C. L. Ling, K. Oravcova, M. Pinheiro, L. Wells, J. M. Bryant, T. D. McHugh, et al. "Genomic Investigations Unmask Mycoplasma amphoriforme, a New Respiratory Pathogen." Clinical Infectious Diseases 60, no. 3 (October 23, 2014): 381–88. http://dx.doi.org/10.1093/cid/ciu820.

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10

Schleihauf, Emily, Sumana Fathima, Janice Pettipas, Jason J. LeBlanc, Todd F. Hatchette, Steven J. Drews, and David Haldane. "Respiratory Outbreak Investigations: How Many Specimens Should Be Tested?" Infection Control & Hospital Epidemiology 36, no. 11 (July 16, 2015): 1344–47. http://dx.doi.org/10.1017/ice.2015.171.

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To determine the optimal number of specimens for virus detection in a respiratory outbreak, laboratory results from 2 Canadian public health laboratories were reviewed. The evidence suggests that 3 specimens are sufficient for detection of a virus in >95% of outbreaks, thereby reducing laboratory costs.Infect. Control Hosp. Epidemiol. 2015;36(11): 1344–1347

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Munnich, Arnold, Agnès Rötig, Dominique Chretien, JeanMarie Saudubray, Valérie Cormier, and Pierre Rustin. "Clinical presentations and laboratory investigations in respiratory chain deficiency." European Journal of Pediatrics 155, no. 4 (April 1996): 262–74. http://dx.doi.org/10.1007/bf02002711.

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12

Hadler, S. C., K. G. Castro, W. Dowdle, L. Hicks, G. Noble, and R. Ridzon. "Epidemic Intelligence Service Investigations of Respiratory Illness, 1946-2005." American Journal of Epidemiology 174, suppl 11 (November 30, 2011): S36—S46. http://dx.doi.org/10.1093/aje/kwr309.

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13

Munnich, A., Agnès Rötig, Dominique Chretien, Jean Marie Saudubray, Valérie Cormier, and Pierre Rustin. "Clinical presentations and laboratory investigations in respiratory chain deficiency." European Journal of Pediatrics 155, no. 4 (March 11, 1996): 262–74. http://dx.doi.org/10.1007/s004310050399.

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TOADER, Corneliu, Mioriţa TOADER, and Iolanda Cristina VIVISENCO. "Rare case of esophageal foreign body with respiratory manifestations." Romanian Journal of Medical Practice 10, no. 1 (March 31, 2015): 79–81. http://dx.doi.org/10.37897/rjmp.2015.1.13.

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The authors present a clinical case of esophageal foreign body with exclusive respiratory symptomatology, which generated significant diagnostic difficulties. Careful and detailed anamnesis, coupled with a broad range of investigations enabled us to establish the correct diagnosis and proper treatment.

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Fedoseev, Gleb Borisovich, B. I. Trofimov, N. N. Rogacheva, T. S. Razumovskaya, G. B. Fedoseev, V. I. Trofimov, N. N. Rogacheva, and N. S. Razumovskaya. "NEUTROPHILS AND RESPIRATORY TRACT BACTERIAL INFECTIONS IN PATIENTS WITH BRONCHIAL ASTHMA AND COPD." Russian Journal of Allergy 8, no. 2 (June 15, 2011): 34–43. http://dx.doi.org/10.36691/rja785.

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The article concerns the role of respiratory tract bacterial infections in development of bronchial asthma and COPD. Analysis is based on current publications and results of clinical investigations. Ability of neutrophils to protect the respiratory system from bacterial agents is underlined. The results obtained during investigation of 132 bronchial asthma and 33 COPD patients showed that in allergic asthma patients high percentage of sputum neutrophils is associated with normal FEV1% and mild course of the disease. In COPD patients high percentage of sputum neutrophils is usually associated with low FEV1%. It is proposed, that in these patients functional activity of neutrophils is associated with predominant injury of respiratory structures.

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Thiboutot, Jeffrey, and Kyle T. Bramley. "Ultrasound-Guided Pleural Investigations." Clinics in Chest Medicine 42, no. 4 (December 2021): 591–97. http://dx.doi.org/10.1016/j.ccm.2021.07.002.

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PECI, A., A. MARCHAND-AUSTIN, A.-J. WINTER, and J. B. GUBBAY. "Optimal number of samples to test for institutional respiratory infection outbreaks in Ontario." Epidemiology and Infection 141, no. 8 (November 12, 2012): 1781–85. http://dx.doi.org/10.1017/s0950268812002531.

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SUMMARYThe objective of this study was to determine the optimal number of respiratory samples per outbreak to be tested for institutional respiratory outbreaks in Ontario. We reviewed respiratory samples tested for respiratory viruses by multiplex PCR as part of outbreak investigations. We documented outbreaks that were positive for any respiratory viruses and for influenza alone. At least one virus was detected in 1454 (85·2%) outbreaks. The ability to detect influenza or any respiratory virus increased as the number of samples tested increased. When analysed by chronological order of when samples were received at the laboratory, percent positivity of outbreaks testing positive for any respiratory virus including influenza increased with the number of samples tested up to the ninth sample, with minimal benefit beyond the fourth sample tested. Testing up to four respiratory samples per outbreak was sufficient to detect viral organisms and resulted in significant savings for outbreak investigations.

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Praneetha, Gadiraju Durga. "A Rare Case of Pulmonary Thromboembolism and Acute Respiratory Distress Syndrome (ARDS) in Scrub Typhus." Journal of Communicable Diseases 54, no. 1 (March 31, 2022): 36–40. http://dx.doi.org/10.24321/0019.5138.202247.

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Orientia tsutsugamushi causes scrub typhus, a zoonotic illness (O tsutsugamushi). The disease is spread to humans through the biting of trombiculid mite larvae (chiggers). The case report adds light to thrombus formation in scrub typhus infection, an often-under-diagnosed entity. We report a 17-year-old female who presented with complaints of breathlessness after 11 days of symptoms of fever. The condition is widespread in India, with cases reported in a number of states. Persons are infected by the larval development (chigger) of trombiculid mites. Chiggers are spread by wild rats, and illness develops when chiggers feed on humans.Laboratory investigations revealed leukocytosis, thrombocytopenia, and radiological investigations showed ARDS and pleural effusion, and the patient was diagnosed to have scrub typhus. Treatment was given for the infection and its complications.

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Periselneris, J., and J. S. Brown. "A clinical approach to respiratory disease in patients with hematological malignancy, with a focus on respiratory infection." Medical Mycology 57, Supplement_3 (June 1, 2019): S318—S327. http://dx.doi.org/10.1093/mmy/myy138.

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AbstractRespiratory complications, in particular infections, are common in the setting of hematological malignancy and after hematopoetic stem cell transplant. The symptoms can be nonspecific; therefore, it can be difficult to identify and treat the cause. However, an understanding of the specific immune defect, clinical parameters such as speed of onset, and radiological findings, allows the logical diagnostic and treatment plan to be made. Radiological findings can include consolidation, nodules, and diffuse changes such as ground glass and tree-in-bud changes. Common infections that induce these symptoms include bacterial pneumonia, invasive fungal disease, Pneumocystis jirovecii and respiratory viruses. These infections must be differentiated from inflammatory complications that often require immune suppressive treatment. The diagnosis can be refined with the aid of investigations such as bronchoscopy, computed tomography (CT) guided lung biopsy, culture, and serological tests. This article gives a schema to approach patients with respiratory symptoms in this patient group; however, in the common scenario of a rapidly deteriorating patient, treatment often has to begin empirically, with the aim to de-escalate treatment subsequently after targeted investigations.

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Cates, Jordan, Lisa Trieu, Douglas Proops, and Shama Desai Ahuja. "Contact Investigations Around Mycobacterium tuberculosis Patients Without Positive Respiratory Culture." Journal of Public Health Management and Practice 22, no. 3 (2016): 275–82. http://dx.doi.org/10.1097/phh.0000000000000261.

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21

LÖFSTRÖM, GUNNAR. "Investigations into the Acute Infections of the Upper Respiratory Tract." Acta Medica Scandinavica 121, no. 2-3 (April 24, 2009): 138–55. http://dx.doi.org/10.1111/j.0954-6820.1945.tb06874.x.

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22

Hummel, Thomas, Tobias Haenel, Elisabeth Pauli, Will West, Thomas Zahnert, and David Hull. "Investigations in subjects with cough following upper respiratory tract infection." Respiratory Physiology & Neurobiology 156, no. 1 (April 2007): 79–84. http://dx.doi.org/10.1016/j.resp.2006.08.003.

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23

KUECHLER, S., C. HOINKIS, C. THIERFELDER, B. BECKER, P. ZAHN, P. GEYER, and D. LEHMANN. "Respiratory motion - first investigations on the optimization of gating parameters." International Journal of Radiation OncologyBiologyPhysics 60 (September 2004): S579. http://dx.doi.org/10.1016/s0360-3016(04)01874-7.

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24

Kuechler, S., C. Hoinkis, C. Thierfelder, B. Becker, P. Zahn, P. Geyer, and D. Lehmann. "Respiratory motion - first investigations on the optimization of gating parameters." International Journal of Radiation Oncology*Biology*Physics 60, no. 1 (September 2004): S579. http://dx.doi.org/10.1016/j.ijrobp.2004.07.570.

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25

Tarro, Giulio, Riccardo Smeraglia, and Ciro Esposito. "Serological and virological investigations of young children with acute respiratory syndrome associated with respiratory syncytial virus." Diagnostic Microbiology and Infectious Disease 3, no. 1 (January 1985): 81–85. http://dx.doi.org/10.1016/0732-8893(85)90072-0.

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26

Cordisco, Marco, Maria Stella Lucente, Alessio Sposato, Roberta Cardone, Francesco Pellegrini, Delia Franchini, Antonio Di Bello, and Stefano Ciccarelli. "Canine Parainfluenza Virus Infection in a Dog with Acute Respiratory Disease." Veterinary Sciences 9, no. 7 (July 9, 2022): 346. http://dx.doi.org/10.3390/vetsci9070346.

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The canine infectious respiratory disease complex (CIRDC) is an endemic respiratory syndrome caused by different bacterial and viral pathogens. This report describes a case of canine parainfluenza virus infection in a vaccinated household dog with an acute respiratory symptom (dry cough), who underwent clinical and endoscopic investigations for a suspected foreign body. Cytological investigations carried out on the broncho-alveolar lavage fluid (BALF) tested negative for the presence of inflammatory or infectious processes and could have been misleading the clinicians. By the molecular analyses (PCR) carried out on the BALF, canine parainfluenza virus was exclusively detected without the simultaneous presence of other respiratory pathogens associated to CIRDC. This case report emphasizes the role of molecular diagnostics in the differential diagnosis of respiratory diseases, in order to avoid underestimating the circulation of the parainfluenza virus in the canine population.

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27

Grossman, Ronald F. "Diagnosis of Respiratory Tract Infection and the Use of the Laboratory." Canadian Journal of Infectious Diseases 5, suppl c (1994): 34C—41C. http://dx.doi.org/10.1155/1994/984530.

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Lower respiratory tract infections continue to be among the most common illnesses requiring medical attention with considerable morbidity and morality. Clinical features, including underlying conditions, presenting signs and symptoms, basic laboratory investigations and chest roentgenograms, are not sufficiently precise to infer an etiological agent. These investigations do permit an assessment of severity of illness and can assist in stratification of patients into high risk groups. Properly performed and interpreted Gram stain of sputum is still useful in the initial assessment of these patients, but sputum cultures are less helpful. Blood cultures should be drawn in patients ill enough to require hospitalization, but the yield is low, Pneumococcal antigen testing and serological studies do not add to the routine management of patients with pneumonia. In patients with nosocomial pneumonia, the diagnosis will be established by a synthesis of clinical, roentgenographic and simple laboratory results such as sputum analysis and blood culture. Invasive investigations should be reserved for critically ill patients.

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Chan, HY, CC Wong, and F. Ng. "Late-Presenting Congenital Diaphragmatic Hernia: A Potentially Life Threatening Case." Hong Kong Journal of Emergency Medicine 16, no. 2 (April 2009): 102–5. http://dx.doi.org/10.1177/102490790901600208.

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Congenital diaphragmatic hernia (CDH) generally presents with respiratory distress in the neonatal period. Late onset CDH is less common and is associated with a wide range of clinical symptoms. We report a case of a 4-year-old child presenting with sudden onset of dizziness, abdominal pain and vomiting after swimming. Radiological investigations showed a left CDH with mediastinal shift. She gradually developed respiratory distress after admission. Urgent operation showed that the contents of the hernia included stomach, spleen, small and large bowels. This case highlights the importance of suspicion of CDH, proper clinical examination and investigation of children with acute non-specific gastrointestinal complaints.

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Khoury, Maroun, Jimena Cuenca, Fernanda F. Cruz, Fernando E. Figueroa, Patricia R. M. Rocco, and Daniel J. Weiss. "Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19." European Respiratory Journal 55, no. 6 (April 7, 2020): 2000858. http://dx.doi.org/10.1183/13993003.00858-2020.

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The severe respiratory consequences of the coronavirus disease 2019 (COVID-19) pandemic have prompted urgent need for novel therapies. Cell-based approaches, primarily using mesenchymal stem (stromal) cells (MSCs), have demonstrated safety and possible efficacy in patients with acute respiratory distress syndrome (ARDS), although they are not yet well studied in respiratory virus-induced ARDS. Limited pre-clinical data suggest that systemic MSC administration can significantly reduce respiratory virus (influenza strains H5N1 and H9N2)-induced lung injury; however, there are no available data in models of coronavirus respiratory infection.There is a rapidly increasing number of clinical investigations of cell-based therapy approaches for COVID-19. These utilise a range of different cell sources, doses, dosing strategies and targeted patient populations. To provide a rational strategy to maximise potential therapeutic use, it is critically important to understand the relevant pre-clinical studies and postulated mechanisms of MSC actions in respiratory virus-induced lung injuries. This review presents these, along with consideration of current clinical investigations.

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30

Begin, R., A. Cantin, and S. Masse. "Recent advances in the pathogenesis and clinical assessment of mineral dust pneumoconioses: asbestosis, silicosis and coal pneumoconiosis." European Respiratory Journal 2, no. 10 (November 1, 1989): 988–1001. http://dx.doi.org/10.1183/09031936.93.02100988.

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Recent investigations of the fundamental mechanisms of the mineral dust diseases have substantially increased our understanding of the pathogenesis of the pneumoconioses. In all the mineral dust pneumoconioses, the initial early lung lesion is a fibrosing macrophagic alveolitis. The additional contribution of other lung cell populations is currently under investigation and may identify specific processes for each of the pneumoconioses. Clinical investigations have also progressed with new tools such as Gallium-67 lung scanning, bronchoalveolar lavage analyses, and CT scanning of the thorax; their established values are reviewed in this paper, and areas where progress is needed are considered. The clinical progress in the mineral dust diseases is clearly linked to the basic understanding of the mechanisms of these diseases.

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Basanets, A. V., O. V. Yermakova, L. B. Kriukova, V. A. Gvozdetsky, and N. V. Zhurahovskaya. "ACUTE RESPIRATORY DISEASE COVID-19 AS OCCUPATIONAL DISEASE." Ukrainian Pulmonology Journal 29, no. 2 (2021): 25–29. http://dx.doi.org/10.31215/2306-4927-2021-29-2-25-29.

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Introduction. Acute respiratory disease COVID-19 is a new condition, which has been included into the list of occupational diseases by the decree of Cabinet of Ministers of Ukrane �About correction of the list of occupational diseases� # 394 on 13 May 2020. Medical staff is a professional group of high risk of SARS-CoV-2 infection. At the same time, the cases of COVID-19 in medical personnel are quite rarely acknowledged as an occupational disease. Aim � to evaluate the reasons of low COVID-19 occupational morbidity in Ukraine. Materials and methods. Statistics data regarding COVID-19 cases in medical personnel, approved as occupational disease as of 23 Mar 2021 in Ukraine were analyzed. Results and discussion. As of 23 Mar 2021 COVID-19 has been diagnosed in 71174 healthcare workers. The investigation confirmed an occupational disease in 4758 workers (6,7 % of all cases or 26 % of investigation completed cases), including 256 (0,3 %) lethal cases. Thus, in majority of cases an occupational character of the disease was not confirmed. The following reasons of such a situation have been identified: 1.The administration of healthcare institutions deliberately hides such the cases; emergency notification about the occurrence of acute occupational disease is often not forwarded to responsible authority. 2. Healthcare providers insufficiently employ occupational diseases specialists, due to lack of funding for occupational diseases service on the second level of healthcare system. 3. Epidemiological investigation of acute disease case is not thorough. It is difficult later to identify the site and source of infection, making it impossible to establish a connection of a disease with work conditions. 4. Ukraine State Epidemiological Service has been liquidated, whereas epidemiological investigations belonged to the competency of this organization. 5. Training of epidemiologists and occupational health specialists has been stopped in Ukraine, complicating timely investigation of COVID-19 occupational infection at the time of pandemic. As an example, there has been presented the case of occupational COVID-19 in current article. Key words: coronavirus disease 2019: healthcare workers, occupational diseases

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32

Bartu, Vaclava. "Importance of TB contact investigations." Respiratory Medicine Case Reports 18 (2016): 87–89. http://dx.doi.org/10.1016/j.rmcr.2016.05.001.

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33

Stout, Susan A., and Hartmut Derendorf. "Local Treatment of Respiratory Infections with Antibiotics." Drug Intelligence & Clinical Pharmacy 21, no. 4 (April 1987): 322–29. http://dx.doi.org/10.1177/106002808702100402.

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Local administration of antibiotics for the treatment of respiratory infections has the potential advantage of reduced systemic toxicity and increased drug concentration at the site of infection. This article reviews the basic principles of pulmonary drug delivery using aerosols and the clinical efficacy of local antibiotic therapy of respiratory infections. Clinical studies have been conducted with locally administered aminoglycosides, penicillins, cephalosporins, and polypeptides. The results of these investigations and the pharmacokinetic aspects of pulmonary antibiotic delivery are summarized.

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34

Rozenblat, V. V., S. N. Malafeeva, and V. M. Povodator. "Distortions of respiratory parameters during muscular work in investigations using masks." Bulletin of Experimental Biology and Medicine 99, no. 1 (January 1985): 142–45. http://dx.doi.org/10.1007/bf00806641.

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35

Ionascu, Dan, Steve B. Jiang, Seiko Nishioka, Hiroki Shirato, and Ross I. Berbeco. "Internal-external correlation investigations of respiratory induced motion of lung tumors." Medical Physics 34, no. 10 (September 19, 2007): 3893–903. http://dx.doi.org/10.1118/1.2779941.

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36

Charton, F., P. L. Conan, H. Le Floch, O. Bylicki, W. Gaspard, C. Soler, J. Margery, and F. Rivière. "Evaluation of pneumococcal urinary antigen testing for respiratory tract infection investigations." Médecine et Maladies Infectieuses 50, no. 1 (February 2020): 57–62. http://dx.doi.org/10.1016/j.medmal.2019.06.009.

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37

Singh, Varinder. "Bronchoscopy and other key investigations in pediatric respiratory disorders: 2nd Edition." Indian Pediatrics 50, no. 10 (October 2013): 982. http://dx.doi.org/10.1007/s13312-013-0253-3.

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38

Strugnell, B. W., M. P. Dagleish, C. W. Bayne, M. Brown, H. L. Ainsworth, R. A. J. Nicholas, A. Wood, and J. C. Hodgson. "Investigations into an outbreak of corvid respiratory disease associated withPasteurella multocida." Avian Pathology 40, no. 3 (June 2011): 329–36. http://dx.doi.org/10.1080/03079457.2011.571659.

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39

Turton, Nadia, Neve Cufflin, Mollie Dewsbury, Olivia Fitzpatrick, Rahida Islam, Lowidka Linares Watler, Cara McPartland, et al. "The Biochemical Assessment of Mitochondrial Respiratory Chain Disorders." International Journal of Molecular Sciences 23, no. 13 (July 5, 2022): 7487. http://dx.doi.org/10.3390/ijms23137487.

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Mitochondrial respiratory chain (MRC) disorders are a complex group of diseases whose diagnosis requires a multidisciplinary approach in which the biochemical investigations play an important role. Initial investigations include metabolite analysis in both blood and urine and the measurement of lactate, pyruvate and amino acid levels, as well as urine organic acids. Recently, hormone-like cytokines, such as fibroblast growth factor-21 (FGF-21), have also been used as a means of assessing evidence of MRC dysfunction, although work is still required to confirm their diagnostic utility and reliability. The assessment of evidence of oxidative stress may also be an important parameter to consider in the diagnosis of MRC function in view of its association with mitochondrial dysfunction. At present, due to the lack of reliable biomarkers available for assessing evidence of MRC dysfunction, the spectrophotometric determination of MRC enzyme activities in skeletal muscle or tissue from the disease-presenting organ is considered the ‘Gold Standard’ biochemical method to provide evidence of MRC dysfunction. The purpose of this review is to outline a number of biochemical methods that may provide diagnostic evidence of MRC dysfunction in patients.

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Monne Rodriguez, Josep Maria, Gail Leeming, Kernt Köhler, and Anja Kipar. "Feline Herpesvirus Pneumonia: Investigations Into the Pathogenesis." Veterinary Pathology 54, no. 6 (August 16, 2017): 922–32. http://dx.doi.org/10.1177/0300985817720982.

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Feline herpesvirus type 1 (FeHV-1) is one of the etiological agents of feline respiratory disease. FeHV-1 is an epitheliotropic and cytopathic virus that mainly causes rhinitis and conjunctivitis, although pneumonia is also occasionally seen. In this study, the authors investigated the pathogenesis of FeHV-1-associated pneumonia, comparing natural cases with viral infection of tracheal ring and cell cultures in vitro, using histology, immunohistology, double immunofluorescence, and transmission electron microscopy as investigative tools. The results confirm that FeHV-1 targets both respiratory epithelial cells and pneumocytes and indicate that FeHV-1 pneumonia is the consequence of continuous cell-to-cell viral spread from the upper airways via the trachea into the lungs. They provide strong evidence that FeHV-1–infected cells die primarily via apoptosis, following loss of cell-to-cell contact, rounding, and detachment. However, virus-induced lesions in vivo are dominated by marked neutrophil infiltration and extensive necrosis with less prominent apoptosis; in the airways, the tissue necrosis can extend into the submucosa. The necrosis appears to result from virus-induced neutrophil influx and release of proteolytic enzymes, such as matrix metalloproteinase-9, from the neutrophils.

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Schmitz, J. E., F. W. Ahnefeld, A. Grunert, J. Kilian, and W. Dick. "Investigations of Vital Functions of Severely Injured Patients in the Early Period after Trauma." Prehospital and Disaster Medicine 1, S1 (1985): 191–94. http://dx.doi.org/10.1017/s1049023x00044435.

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The main aim of the primary treatment of polytraumatized patients at the accident site is the stabilization and maintenance of vital functions, especially the cardiocirculatory and the respiratory systems. The next step in the rescue chain is rapid transport to the nearest hospital with the ability to manage critically injured patients. Because of the difficulty in carrying out measurements in such critical situations, very little reliable data concerning trauma induced changes in respiratory function and metabolism is available. Clinical experience has shown that even after successfully recovering from the acute stress phase, a trauma related progressive respiratory distress syndrome can nevertheless develop during the first few days following injury.Recent studies led to the conclusion that the late development of respiratory distress syndrome is already induced during the early shock phase. Early discovery and adequate treatment of trauma related metabolic and respiratory dysfunctions have a decisive influence on current status and outcome.

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Cuppari, Caterina, Maria Concetta Cutrupi, Annamaria Salpietro, Alessia Sallemi, Monica Fusco, Giuseppe Fabio Parisi, and Carmelo Salpietro. "Genetic Anomalies of the Respiratory Tract." Current Respiratory Medicine Reviews 15, no. 3 (January 1, 2020): 221–30. http://dx.doi.org/10.2174/1573398x15666191022100525.

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Hereditary lung diseases can affect the airways, parenchyma and vasculature of the lung. Such diseases comprehend simple monogenic disorders such as Kartagener syndrome and α1-antitrypsin deficiency, in which mutations of critical genes are sufficient to induce well‐defined disease phenotypes. A major comprehension of the genetic basis of pulmonary diseases has produced new investigations into their underlying pathophysiology and contributed sometimes to clarify on more frequent sporadic forms. The presence of these structural abnormalities of the respiratory tract can be fatal, so that the identification of causative genes has allowed prenatal diagnosis for many diseases giving a greater hope of survival thanks to a more adequate and prompt management.

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Constable, H., F. Wood, and Kevin Jones. "The patient with Acute Muscular Weakness." Acute Medicine Journal 13, no. 1 (January 1, 2014): 36–41. http://dx.doi.org/10.52964/amja.0339.

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Proximal muscle weakness can present acutely or subacutely to the Acute Medical Unit. Early diagnosis of the underlying pathology is essential due to life threatening complications such as respiratory failure and cardiac disturbances as well as causing significant levels of disability. The diagnosis requires thorough history-taking and examination to discern evidence of true weakness, assess its onset, distribution and severity followed by extensive investigations including a CK level, which if high should raise suspicion of rhabdomyolysis. Assessment of respiratory function should be done promptly to identify patients with associated respiratory muscle weakness and treatment should not be delayed waiting for definitive and confirmatory investigations. Poor response to treatment is unusual when diagnosis is correct; this raises the possibility of an alternative diagnosis.

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Coleman, H., J. Sutherland, and N. Calder. "Severe acute respiratory syndrome coronavirus-2 in post-laryngectomy patients: case series of four patients." Journal of Laryngology & Otology 134, no. 8 (June 23, 2020): 747–49. http://dx.doi.org/10.1017/s0022215120001310.

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AbstractObjectiveTo report our experience of diagnosis, investigation and management in patients who had undergone laryngectomy secondary to previous squamous cell carcinoma, who were subsequently infected with severe acute respiratory syndrome coronavirus-2 during the coronavirus disease 2019 pandemic.Case reportsFour post-laryngectomy patients with laboratory-proven severe acute respiratory syndrome coronavirus-2 infection were admitted to our institution from 1 March to 1 May 2020. All patients displayed symptoms of coronavirus disease 2019 and underwent investigations, including swab and serum sampling, and chest X-ray where indicated. All were managed conservatively on dedicated coronavirus disease 2019 wards and were discharged without the requirement of higher level care.ConclusionIt is hypothesised that laryngectomy may offer a protective effect against severe or critical disease in severe acute respiratory syndrome coronavirus-2 infection. We hope sharing our experience will aid all practitioners in the management of this, often intimidating, cohort of patients.

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Li, Moyi, Congyang Zhou, Jian Jiang, Huangjun You, Chongchong Liu, Peng Shen, and Zhen Feng. "Investigations on the Respiratory Function in COVID-19 Patients: A Prospective Cohort Study." BioMed Research International 2021 (December 26, 2021): 1–5. http://dx.doi.org/10.1155/2021/9928276.

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Introduction. Coronavirus disease 2019 (COVID-19) is a global public health crisis. However, whether it can cause respiratory dysfunction or physical and psychological disorders in patients remains unknown. Thus, this study was conducted to investigate the respiratory function, activities of daily living, quality of life, and mental status of patients with COVID-19. Participants and outcomes. Data was collected from the follow-up of eligible patients who attended the fever clinic of three hospitals in Jiangxi Province, from March to May 2020. The outcomes included respiratory muscle function, degree of dyspnea, aerobic capacity, activities of daily living, quality of life, and mental status. Results. A total of 139 patients (72 men and 67 women) were included in this study. The proportions of mild, moderate, severe, and critical cases of COVID-19 were 7.1% (10 cases), 68.3% (95 cases), 20.1% (28 cases), and 4.2% (6 cases), respectively. The rates of abnormal maximal inspiratory pressure were 10.0%, 25.2%, 25.0%, and 16.7%, respectively. There were 50%, 65.3%, 50%, and 66.7% of the patients with abnormal dyspnea in the four clinical classifications, respectively. Patients generally show a decline in quality of life, anxiety, and depression symptoms. Conclusions. Respiratory dysfunction, decreased quality of life, and psychological disorders were present in each clinical classification of COVID-19. Therefore, it is necessary to carry out respiratory rehabilitation and psychological intervention for COVID-19 patients.

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Veeranki, Sreenivas P. "Metformin use and asthma: Further investigations." Respirology 22, no. 1 (October 26, 2016): 203. http://dx.doi.org/10.1111/resp.12923.

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Khawcharoenporn, T., and K. Noisang. "Incomplete contact investigation and risk of developing TB among healthcare professionals." International Journal of Tuberculosis and Lung Disease 26, no. 2 (February 1, 2022): 111–18. http://dx.doi.org/10.5588/ijtld.21.0466.

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BACKGROUND: Data on the impact of incomplete contact investigation on TB incidence among healthcare professionals (HCPs) after TB exposure are limited.METHODS: This was a prospective cohort study with 2-year follow-up among Thai HCPs exposed to TB to determine TB incidences and factors associated with TB development.RESULTS: Of the 398 HCPs with TB exposure, 367 (92%) participated in the study; 342 HCPs were included in the final analysis; 311 participated in contact investigations; 303 underwent chest X-ray; 252 completed baseline TB and latent TB infection screening using tuberculin skin test (TST); 210 had negative baseline TST; and 45 completed follow-up tests at 3 months. Altogether, 20 HCPs developed TB (2.92/100 person-years). TB incidences in HCPs not participating in or not completing the investigation at any step were higher than in those who completed the evaluation (11.29 and 2.90, respectively, vs. 0/100 person-years; P < 0.05). No participation in contact investigation and no baseline chest X-ray were independent factors associated with TB development (adjusted odds ratio [aOR] 6.7; P < 0.001 and aOR 8.9; P = 0.01, respectively).CONCLUSION: Study findings indicate increased risks of TB development among HCPs not undergoing or not completing contact investigations and underscore the need for interventions to improve contact investigation participation and completeness.

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Neuzil, Kathleen M. "Progress toward a Respiratory Syncytial Virus Vaccine." Clinical and Vaccine Immunology 23, no. 3 (January 27, 2016): 186–88. http://dx.doi.org/10.1128/cvi.00037-16.

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ABSTRACTIn accompanying papers (P. L. Acosta, M. T. Caballero, and F. P. Polack, Clin Vaccine Immunol 23:189–195, 2016,http://dx.doi.org/10.1128/CVI.00609-15; M. Vissers, I. M. L. Ahout, M. I. de Jonge, and G. Ferwerda, Clin Vaccine Immunol 23:243–245, 2016,http://dx.doi.org/10.1128/CVI.00590-15) in this issue ofClinical and Vaccine Immunology, the history of and immune mechanisms underlying vaccine-enhanced respiratory syncytial virus (RSV) disease and of investigations of mucosal antibodies and their association with viral load in RSV-infected children, respectively, are described. This commentary discusses RSV vaccine candidates, target populations, and the challenges associated with achieving a safe and effective vaccine.

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Schechter, Michael S. "Snoring: Investigations guidelines." Pediatric Pulmonology 37, S26 (2004): 172–74. http://dx.doi.org/10.1002/ppul.70096.

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Hynes, H. Patricia, Doug Brugge, Neal-Dra Osgood, John Snell, Jose Vallarino, and John Spengler. "Investigations into the Indoor Environment and Respiratory Health in Boston Public Housing." Reviews on Environmental Health 19, no. 3-4 (July 1, 2004): 271–90. http://dx.doi.org/10.1515/reveh-2004-19-3-407.

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Abstract The self-reported prevalence of asthma in the United States increased by 75% from 1980 to 1994, a trend found to be significant and evident in every region of the country. The increase was most marked in children from birth to 14 years of age; and growing evidence indicates that, as with lead poisoning, inner-city and urban populations are most at risk. Attention has turned to the role of indoor environmental risk factors, especially in homes and schools. Such factors include moisture and mold growth, pest infestation, dust mites, the building envelope, heating systems, inadequate Ventilation, nitrogen dioxide, and environmental tobacco smoke. The Healthy Public Housing Initiative (HPHI) is a Boston-based communitycentered research and intervention project designed to engage Boston Housing Authority residents in a collaborative process to improve respiratory health, quality of life, building conditions, and building maintenance in public housing. This article summarizes the significant research findings from four pilot studies in housing developments that laid the foundation for the larger HPHI asthma-related environmental intervention study. The research design for the pilot projects is informed by principles of community-collaborative research. The strengths of this model of research for our work are also discussed.

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