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Journal articles on the topic 'Resistance paradigm'

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Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Desoize, B. "Multicellular resistance: a paradigm for clinical resistance?" Critical Reviews in Oncology/Hematology 36, no. 2-3 (November 2000): 193–207. http://dx.doi.org/10.1016/s1040-8428(00)00086-x.

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2

Ruiz, Autumn, and Stephen J. Russell. "A new paradigm in viral resistance." Cell Research 22, no. 11 (October 2, 2012): 1515–17. http://dx.doi.org/10.1038/cr.2012.139.

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3

Ho, Wing-Chung. "James Scott's resistance/hegemony paradigm reconsidered." Acta Politica 46, no. 1 (January 2011): 43–59. http://dx.doi.org/10.1057/ap.2010.5.

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4

Holohan, Caitriona, Sandra Van Schaeybroeck, Daniel B. Longley, and Patrick G. Johnston. "Cancer drug resistance: an evolving paradigm." Nature Reviews Cancer 13, no. 10 (September 24, 2013): 714–26. http://dx.doi.org/10.1038/nrc3599.

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5

Seppälä, Tiina. "Biopolitics, Resistance and the Neoliberal Development Paradigm." Journal für Entwicklungspolitik 30, no. 1 (2014): 88–103. http://dx.doi.org/10.20446/jep-2414-3197-30-1-88.

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6

Bowman, Richard. "Slip Resistance – Adjusting to a New Paradigm." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 44, no. 28 (July 2000): 490–93. http://dx.doi.org/10.1177/154193120004402820.

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7

Lautt, W. Wayne. "A Proposed New Paradigm for Insulin Resistance." Metabolic Syndrome and Related Disorders 1, no. 4 (December 2003): 261–70. http://dx.doi.org/10.1089/1540419031361417.

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8

Mathews, Brandon, and Christopher M. Linski. "Shifting the paradigm: reevaluating resistance to organizational change." Journal of Organizational Change Management 29, no. 6 (October 3, 2016): 963–72. http://dx.doi.org/10.1108/jocm-03-2016-0058.

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Purpose The purpose of this paper is to challenge the existing paradigm of resistance to organizational change by offering a novel, interdisciplinary perspective. More specifically, this paper seeks to detach from traditional formulations of resistance to change and introduce a new paradigm, reevaluating resistance through the Good Lives Model (GLM) and the concept of Primary Human Goods (PHG). Design/methodology/approach This conceptual paper uses contemporary literature on resistance to organizational change to make the case that the existing paradigm is one of negativity and deficiency. The authors define resistance, as currently formulated, subsequently offering a new perspective through the GLM. The etiological underpinnings of the model are provided and the concept of PHG is defined to illustrate relevance in reevaluating resistance to change. Findings The paper illustrates that resistance behaviors are not individual problems of employees, which must be overcome for successful change. Rather, resistance behaviors are the manifestation of disruptions to the achievement of PHG. Moreover, the paper demonstrates the pursuit of PHG is an innately positive, human activity that change strategies should take into account. The Dialogic Organization Development approach is also integrated as a means to uncover priority goods and disruptions that may impact them. Originality/value The paper provides a novel reevaluation of resistance to change through the interdisciplinary application of the GLM and PHG. Further, the paper uses the model to integrate several fundamental theories of human motivation into one cohesive, consistent framework.

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9

Bangsberg, David R. "A Paradigm Shift to Prevent HIV Drug Resistance." PLoS Medicine 5, no. 5 (May 20, 2008): e111. http://dx.doi.org/10.1371/journal.pmed.0050111.

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10

Raoult, Didier, and Jean-Marc Rolain. "The Paradigm of the Shadoks and Antibiotic Resistance." Clinical Infectious Diseases 69, no. 9 (March 6, 2019): 1641. http://dx.doi.org/10.1093/cid/ciz183.

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11

Brown, James K. M. "A cost of disease resistance: paradigm or peculiarity?" Trends in Genetics 19, no. 12 (December 2003): 667–71. http://dx.doi.org/10.1016/j.tig.2003.10.008.

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12

Munck, Ronaldo. "Social Movements in Latin America: Paradigms, People, and Politics." Latin American Perspectives 47, no. 4 (June 12, 2020): 20–39. http://dx.doi.org/10.1177/0094582x20927007.

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Social movements in Latin America have always attracted attention, but there is no agreed-upon paradigm, certainly not one accepted in Latin America. A review from a Latin American perspective of the strengths and weaknesses of the theoretical paradigms used to understand these movements suggests a revitalized paradigm that foregrounds the agency of people and, above all, brings politics back in. A proposed new, poststructuralist Marxist frame for research on both theory and practice puts a Foucauldian emphasis on the dissoluble links between power and resistance and a Laclau-inspired emphasis on the national-popular. Aunque los movimientos sociales en América Latina siempre han llamado la atención, no hay un paradigma acordado; ciertamente, no uno que se acepte en la región. Un análisis desde una perspectiva latinoamericana de las fortalezas y debilidades de los paradigmas teóricos utilizados para entender estos movimientos sugiere un marco revitalizado que pone en primer plano la agencia de las personas y, sobre todo, recupera el tema de la política. El nuevo paradigma marxista postestructuralista aquí propuesto para la investigación tanto teórica como práctica pone un énfasis foucauldiano en los vínculos disolubles entre el poder y la resistencia, así como un énfasis en lo nacional y popular inspirado por Laclau.

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13

Eley, Elizabeth, and Mere Berryman. "Paradigm lost." New Zealand Annual Review of Education 25 (August 5, 2021): 95–114. http://dx.doi.org/10.26686/nzaroe.v25.6962.

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The term paradigm lost (with apologies to Milton) references the lost opportunities arising from a discrepancy in both what the New Zealand education context promises and what is implemented in many schools. Honouring the Treaty of Waitangi inherently promises an education system that draws on the worldviews of both Māori and Pākehā. We argue that the schooling model, adopted in 1877 and substantively unchallenged since, does not reflect the views of the uniqueness of every child as contained in the heritages of both Treaty signatory partners. More concerning is that the accompanying assimilatory practices within schooling have perpetuated their disastrous impact on Māori. This article explores the impacts of the ‘lost paradigm’ on students’ sense of self and therefore on their sense of belonging at school. The potential and hope for paradigm regained is also presented, drawing from the responses of educators who have participated in a professional learning and development course, where participants engage in a process of conscientisation, resistance and transformative praxis, that changes both their personal educational practice and that of their school. Through this course, participants experience what Freire (1996) refers to as ‘radical hope’ – the belief that we can make life better for others and change the paradigms that lead to oppression and despair.

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14

Minakshi, Prasad, Mayukh Ghosh, Basanti Brar, Rajesh Kumar, Upendra P. Lambe, Koushlesh Ranjan, Jinu Manoj, and Gaya Prasad. "Nano-antimicrobials: A New Paradigm for Combating Mycobacterial Resistance." Current Pharmaceutical Design 25, no. 13 (August 16, 2019): 1554–79. http://dx.doi.org/10.2174/1381612825666190620094041.

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Background:Mycobacterium group contains several pathogenic bacteria including M. tuberculosis where the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) is alarming for human and animal health around the world. The condition has further aggravated due to the speed of discovery of the newer drugs has been outpaced by the rate of resistance developed in microorganisms, thus requiring alternative combat strategies. For this purpose, nano-antimicrobials have emerged as a potential option.Objective:The current review is focused on providing a detailed account of nanocarriers like liposome, micelles, dendrimers, solid lipid NPs, niosomes, polymeric nanoparticles, nano-suspensions, nano-emulsion, mesoporous silica and alginate-based drug delivery systems along with the recent updates on developments regarding nanoparticle-based therapeutics, vaccines and diagnostic methods developed or under pipeline with their potential benefits and limitations to combat mycobacterial diseases for their successful eradication from the world in future.Results:Distinct morphology and the underlying mechanism of pathogenesis and resistance development in this group of organisms urge improved and novel methods for the early and efficient diagnosis, treatment and vaccination to eradicate the disease. Recent developments in nanotechnology have the potential to meet both the aspects: nano-materials are proven components of several efficient targeted drug delivery systems and the typical physicochemical properties of several nano-formulations have shown to possess distinct bacteriocidal properties. Along with the therapeutic aspects, nano-vaccines and theranostic applications of nano-formulations have grown in popularity in recent times as an effective alternative means to combat different microbial superbugs.Conclusion:Nanomedicine holds a bright prospect to perform a key role in global tuberculosis elimination program.

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15

Rolain, J. M., R. Canton, and G. Cornaglia. "Emergence of antibiotic resistance: need for a new paradigm." Clinical Microbiology and Infection 18, no. 7 (July 2012): 615–16. http://dx.doi.org/10.1111/j.1469-0691.2012.03902.x.

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16

Courtwright, David T. "The NIDA brain disease paradigm: History, resistance and spinoffs." BioSocieties 5, no. 1 (March 2010): 137–47. http://dx.doi.org/10.1057/biosoc.2009.3.

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17

Kuzmenkov, A. Yu, A. G. Vinogradova, I. V. Trushin, A. A. Avramenko, M. V. Edelstein, A. V. Dekhnich, and R. S. Kozlov. "AMRcloud: a new paradigm in monitoring of antibiotic resistance." Clinical Microbiology and Antimicrobial Chemotherapy 21, no. 2 (2019): 119–24. http://dx.doi.org/10.36488/cmac.2019.2.119-124.

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18

Stabile, Carol A. "Resistance, recuperation, and reflexivity: The limits of a paradigm." Critical Studies in Mass Communication 12, no. 4 (December 1995): 403–22. http://dx.doi.org/10.1080/15295039509366948.

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19

Granier, S. "Colistin resistance and public health: A change of paradigm?" International Journal of Infectious Diseases 53 (December 2016): 30. http://dx.doi.org/10.1016/j.ijid.2016.11.082.

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20

Chae, Lee-Ann. "Pacific Resistance." Social Theory and Practice 44, no. 1 (2018): 1–20. http://dx.doi.org/10.5840/soctheorpract201811929.

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It is widely believed that some wars are just, and that the paradigm case of a just war is a defensive war. A familiar strategy used to justify defensive war is to infer its permissibility from the case of self-defensive killing. I show, however, that the permission to defend oneself does not justify killing, but instead calls for nonviolent resistance. I conclude that on the account of self-defense I develop, the appropriate way to respond to a war of aggression is not by prosecuting a defensive war, but by engaging in a form of nonviolence I call pacific resistance.

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21

Khamoshina, Marina B., Yulia S. Artemenko, Ayshan A. Bayramova, Valentina A. Ryabova, and Mekan R. Orazov. "Polycystic ovary syndrome and obesity: a modern paradigm." RUDN Journal of Medicine 26, no. 4 (December 23, 2022): 382–95. http://dx.doi.org/10.22363/2313-0245-2022-26-4-382-395.

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Polycystic ovary syndrome is a heterogeneous endocrine disease that affects women of childbearing age. The pathogenesis of polycystic ovary syndrome has not been fully studied to date, its paradigm considers the genetic determinism of the manifestation of hormonal and metabolic disorders, which are considered to be criteria for the verification of the disease (hyperandrogenism, oligo/anovulation and/or polycystic ovarian transformation during ultrasound examination (ultrasound). This review discusses the main ways of interaction between hyperandrogenism, insulin resistance and obesity and their role in the pathogenesis of polycystic ovary syndrome, as well as possible methods of treatment for this category of patients. The review analyzes the role of hyperandrogenism and insulin resistance in the implementation of the genetic scenario of polycystic ovary syndrome and finds out the reasons why women with polycystic ovary syndrome often demonstrate the presence of a «metabolic trio» - hyperinsulinemia, insulin resistance and type 2 diabetes mellitus. It is noted that obesity is not included in the criteria for the diagnosis of polycystic ovary syndrome, but epidemiological data confirm the existence of a relationship between these diseases. Obesity, especially visceral, which is often found in women with polycystic ovary syndrome, enhances and worsens metabolic and reproductive outcomes with polycystic ovary syndrome, as well as increases insulin resistance and compensatory hyperinsulinemia, which, in turn, stimulates adipogenesis and suppresses lipolysis. Obesity increases the sensitivity of tech cells to luteinizing hormone stimulation and enhances functional hyperandrogenism of the ovaries, increasing the production of androgens by the ovaries. Excess body weight is associated with a large number of inflammatory adipokines, which, in turn, contribute to the growth of insulin resistance and adipogenesis. Obesity and insulin resistance exacerbate the symptoms of hyperandrogenism, forming a vicious circle that contributes to the development of polycystic ovary syndrome. These data allow us to conclude that bariatric surgery can become an alternative to drugs (metformin, thiazolidinedione analogs of glucagon-like peptide-1), which has shown positive results in the treatment of patients with polycystic ovary syndrome and obesity.

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22

Dewangan, Jayant, Sonal Srivastava, and Srikanta Kumar Rath. "Salinomycin: A new paradigm in cancer therapy." Tumor Biology 39, no. 3 (March 2017): 101042831769503. http://dx.doi.org/10.1177/1010428317695035.

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The primary hurdle in the treatment of cancer is acquisition of resistance by the tumor cells toward multiple drugs and selectively targeting the cancer stem cells. This problem was overcome by the chemotherapeutic property of recently discovered drug salinomycin. Exact mechanism of action of salinomycin is not yet known, but there are multiple pathways by which salinomycin inhibits tumor growth. Salinomycin decreases the expression of adenosine triphosphate–binding cassette transporter in multidrug resistance cells and interferes with Akt signaling pathway, Wnt/β-catenin, Hedgehog, and Notch pathways of cancer progression. Salinomycin selectively targets cancer stem cells. The potential of salinomycin to eliminate both cancer stem cells and therapy-resistant cancer cells may characterize the compound as a novel and an efficient chemotherapeutic drug.

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23

Escaja, Tina. "MATERNIDADES DISIDENTES Y PARADIGMAS FEMINISTAS EMANCIPADORES: DE LA RESISTENCIA AL DESTRUCTIVISM/O DE UNA CAÍDA (EN) LIBRE." ConSecuencias 3, no. 1 (November 19, 2022): 71–85. http://dx.doi.org/10.6017/cs.v3i1.15933.

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Dissident motherhood-s appear directly or indirectly in many of my literary and digital productions, always from the perspective of resistance to the patriarchal paradigm. Somehow, these works illustrate a certain evolution in theoretical approaches, from Adrienne Rich's distinction between “motherhood” (institutional, patriarchal, oppressive) and “mothering” (potential empowerment of the mother), to more recent activist and feminist theories, including questionings from an intersectional and decolonial feminism that also reflects on allegedly emancipatory principles of neoliberal base by the third wave of feminism. The poems and projects 13 lunas 13 (2011), and Caída libre (2004), not only resist and redefine the patriarchal paradigm and its Judeo-Christian misogynist-based approach, but also propose a new emancipatory feminist paradigm, a paradigm taken to oppositional resistance as a feminist counter-narrative with the instigation of the Destructivist/a movement in 2014. Finally, the “Feminist Manifesto in Times of Coronoavirus” (2020), intends to bring dissident maternities to a space of eco-Queer, inclusionist, empowerment. Resumen: El tema de la maternidad-maternidades disidentes aparece abordado de forma soslayada o directa en varias de mis publicaciones tanto literarias como digitales, siempre desde la perspectiva de resistencia al paradigma patriarcal. De algún modo, dichas obras ilustran cierta evolución en planteamientos teóricos, desde la diferenciación de Adrienne Rich entre motherhood (institucional, patriarcal, opresor) y mothering (potencial empoderamiento de la madre), a propuestas activistas y feministas en el nuevo milenio, pasando por cuestionamientos desde un feminismo interseccional y descolonial que también reflexiona sobre principios presuntamente emancipadores de base neoliberal auspiciados por la tercera ola del feminismo. El poemario y proyecto 13 lunas 13 (2011), y Caída libre (2004), no sólo resisten y redefinen el paradigma patriarcal y su planteamiento de base misógina judeocristiana, sino que proponen un nuevo paradigma emancipador desde el feminismo, paradigma llevado a nivel de resistencia oposicional a modo de contra-narrativa feminista con la instigación del movimiento Destructivist/a (2014). El “Feminist Manifesto in Times of Coronoavirus” (2020), pretende, por último, llevar el postulado de las maternidades disidentes a un espacio de empoderamiento inclusivo y eco-Queer.

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24

Ma’u, Jean Antunes Rudolf Zico, Syarief Fajaruddin, Clara Bianrethny Monolga Lamahala, Choirul Fuadi, Satya Perdana, and Ardi Ariyanto. "Submissiveness and resistance: Different paradigm between Indonesian language and English." LingTera 6, no. 1 (May 19, 2019): 83–90. http://dx.doi.org/10.21831/lt.v6i1.23966.

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Translation plays greater role in recent time. This phenomenon especially occurs in efforts of bridging meanings and expressions across two different languages or more. In such effort, certainly there should be good understanding toward both the source language and the target language. Unfortunately, the bridge often cannot be constructed well due to the problems of non-equivalence. Therefore, throughout the study the researchers would like to elaborate the techniques that might be used for constructing the bridge between the two languages and the problems that occur during the translation project. In conducting the study, the researchers would strive to translate a copy of presidential decree by applying the selected techniques and by analysing the problems that might appear. The copy of presidential decree had been selected because the copy might not have been available in other languages especially in English. In addition, foreign people and institutions need to learn the decree since they might be doing business that has been associated to the energy in Indonesia. During the study, the researchers applied three techniques and found four problems during the translation project. As conclusion, the researchers found that the three translation techniques have been supporting one to another and the translation problems have been related to the Indonesian culture since the language and culture are inseparable.

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25

Ishchenco, D. A., V. A. Kyryliuk, S. D. Ishchenco, and L. M. Maryshchuk. "PARADIGM OF RESISTANCE TO INTELLIGENCE AND IMPACT UNLIMITED AIRCRAFT COMPLEXES." Проблеми створення, випробування, застосування та експлуатації складних інформаційних систем, no. 18 (December 30, 2020): 73–90. http://dx.doi.org/10.46972/2076-1546.2020.18.08.

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The work shows the relevance of the problem of countering reconnaissance and strike unmanned aircraft systems and the need to improve the scientific and methodological support of its solution according to a certain corresponding paradigm. In the work as a paradigm of countering unmanned aerial systems, it is proposed to consider a conceptual theoretical and methodological model of combating unmanned aerial vehicles, which currently provides opportunities for identifying the problems of developing forces and means of countering unmanned aerial systems. The developed paradigm of counteraction can be an element of scientific and methodological support, contributes to the solution of the problem of the complex use of forces and means of counteraction to reconnaissance and strike unmanned aircraft systems in order to acquire the capabilities of troops (forces) to perform tasks as intended in the conditions of the use of unmanned vehicles. The recognition of such a paradigm by specialists determines that their activities are based on the accepted model of countering unmanned aircraft systems, using the same rules and standards established in the industry. The generality and consistency of approaches that they provide are prerequisites for ensuring the required scientific level of a certain direction of research. The proposed approach outlines the tasks, content, components, principles of assessment of means of counteraction to unmanned aerial vehicles by contributing to the effectiveness of the system of protection of the object from reconnaissance and strike (shock) systems of the enemy, which systematizes knowledge in the subject area. problems of modern armed struggle. The prospect of further research is to clarify the mathematical calculations in accordance with the characteristics of troops (forces), military facility, protection system against reconnaissance and strike (strike) unmanned aerial vehicles of the enemy and samples of military equipment that are part of it.

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26

Alinia, Minoo. "OnBlack Feminist Thought: thinking oppression and resistance through intersectional paradigm." Ethnic and Racial Studies 38, no. 13 (August 24, 2015): 2334–40. http://dx.doi.org/10.1080/01419870.2015.1058492.

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27

Sommer, Morten O. A., Christian Munck, Rasmus Vendler Toft-Kehler, and Dan I. Andersson. "Prediction of antibiotic resistance: time for a new preclinical paradigm?" Nature Reviews Microbiology 15, no. 11 (July 31, 2017): 689–96. http://dx.doi.org/10.1038/nrmicro.2017.75.

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28

Josell, D. "A paradigm for interconnect geometry to reduce grain boundary resistance." Journal of Applied Physics 100, no. 12 (December 15, 2006): 123705. http://dx.doi.org/10.1063/1.2401309.

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29

Nguyen, Liem, and Charles J. Thompson. "Foundations of antibiotic resistance in bacterial physiology: the mycobacterial paradigm." Trends in Microbiology 14, no. 7 (July 2006): 304–12. http://dx.doi.org/10.1016/j.tim.2006.05.005.

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30

Adams, Jenny, Matthew J. Cline, Matt Hubbard, Tiffany McCullough, and Julie Hartman. "A New Paradigm for Post-Cardiac Event Resistance Exercise Guidelines." American Journal of Cardiology 97, no. 2 (January 2006): 281–86. http://dx.doi.org/10.1016/j.amjcard.2005.08.035.

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31

Fu, Yue, Ho-Ching Tiffany Tsui, Kevin E. Bruce, Lok-To Sham, Khadine A. Higgins, John P. Lisher, Krystyna M. Kazmierczak, et al. "A new structural paradigm in copper resistance in Streptococcus pneumoniae." Nature Chemical Biology 9, no. 3 (January 27, 2013): 177–83. http://dx.doi.org/10.1038/nchembio.1168.

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32

Hong, Jun Hwa, Hyun Jin Kim, Kang Seo Park, and Bon Jeong Ku. "Paradigm shift in the management of type B insulin resistance." Annals of Translational Medicine 6, S2 (December 2018): S98. http://dx.doi.org/10.21037/atm.2018.11.21.

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33

Kebaneilwe, Mmapula Diana. "The Vashti Paradigm Resistance as a Strategy for Combating HIV." Ecumenical Review 63, no. 4 (December 2011): 378–83. http://dx.doi.org/10.1111/j.1758-6623.2011.00130.x.

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34

Gill, J. M., and N. Sattar. "Ceramides: a new player in the inflammation-insulin resistance paradigm?" Obesity and metabolism 7, no. 4 (December 15, 2010): 51. http://dx.doi.org/10.14341/2071-8713-5090.

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Gill, J. M. R., and N. Sattar. "Ceramides: A new player in the inflammation–insulin resistance paradigm?" Diabetologia 52, no. 12 (October 3, 2009): 2475–77. http://dx.doi.org/10.1007/s00125-009-1546-x.

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36

Kerbel, R. S., J. Rak, H. Kobayashi, M. S. Man, B. St. Croix, and C. H. Graham. "Multicellular Resistance: A New Paradigm to Explain Aspects of Acquired Drug Resistance of Solid Tumors." Cold Spring Harbor Symposia on Quantitative Biology 59 (January 1, 1994): 661–72. http://dx.doi.org/10.1101/sqb.1994.059.01.076.

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37

Holahan, Charles J., and Rudolf H. Moos. "Life stressors, resistance factors, and improved psychological functioning: An extension of the stress resistance paradigm." Journal of Personality and Social Psychology 58, no. 5 (1990): 909–17. http://dx.doi.org/10.1037/0022-3514.58.5.909.

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38

Moody, Michelle, Ronney B. Panerai, Penelope J. Eames, and John F. Potter. "Cerebral and systemic hemodynamic changes during cognitive and motor activation paradigms." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, no. 6 (June 2005): R1581—R1588. http://dx.doi.org/10.1152/ajpregu.00837.2004.

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Cognitive and/or sensorimotor stimulations of the brain induce increases in cerebral blood flow that are usually associated with increased metabolic demand. We tested the hypothesis that changes in arterial blood pressure (ABP) and arterial Pco2 also take place during brain activation protocols designed to induce hemispheric lateralization, leading to a pressure-autoregulatory response in addition to the metabolic-driven changes usually assumed by brain stimulation paradigms. Continuous recordings of cerebral blood flow velocity [CBFV; bilateral, middle cerebral artery (MCA)], ABP, ECG, and end-tidal Pco2 (PetCO2) were performed in 15 right-handed healthy subjects (aged 21–43 yr), in the seated position, at rest and during 10 repeated presentations of a word generation and a constructional puzzle paradigm that are known to induce differential cortical activation. Derived variables included heart rate, cerebrovascular resistance, critical closing pressure, resistance area product, and the difference between the right and left MCA recordings (CBFVR-L). No adaptation of the CBFVR-L difference was detected for the repeated presentation of 10 activation tasks, for either paradigm. During activation with the word generation tasks, CBFV changed by (mean ± SD) 9.0 ± 3.7% (right MCA, P = 0.0007) and by 12.3 ± 7.6% (left MCA, P = 0.0007), ABP by 7.7 ± 6.0 mmHg ( P = 0.0007), heart rate by 7.1 ± 5.3 beats/min ( P = 0.0008), and PetCO2 by −2.32 ± 2.23 Torr ( P = 0.002). For the puzzle paradigm, CBFV changed by 13.9 ± 6.6% (right MCA, P = 0.0007) and by 11.5 ± 6.2% (left MCA, P = 0.0007), ABP by 7.1 ± 8.4 mmHg ( P = 0.0054), heart rate by 7.9 ± 4.6 beats/min ( P = 0.0008), and PetCO2 by −2.42 ± 2.59 Torr ( P = 0.001). The word paradigm led to greater left hemispheric dominance than the right hemispheric dominance observed with the puzzle paradigm ( P = 0.004). We concluded that significant changes in ABP and PetCO2 levels occur during brain activation protocols, and these contribute to the evoked change in CBFV. A pressure-autoregulatory response can be observed in addition to the hemodynamic changes induced by increases in metabolic demand. Simultaneous changes in Pco2 and heart rate add to the complexity of the response, indicating the need for more detailed modeling and better understanding of brain activation paradigms.

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39

Ferguson, Iain, and Michael Lavalette. "Globalization and global justice." International Social Work 49, no. 3 (May 2006): 309–18. http://dx.doi.org/10.1177/0020872806063401.

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English The transformation of the social work role through the imposition of neo-liberal policies is creating widespread dissatisfaction. This article identifies some bases for resistance to these policies and discusses their potential for informing a new paradigm, based on a rejection of neoliberalism in social work. French L'application des politiques néo-libérales transforme le rôle du travail social, ce qui suscite une insatisfaction généralisée. Cet article identifie certains fondements de la à ces politiques et il en évalue le potentiel pour créer un nouveau paradigme fondé sur le rejet du néo-libéralisme en travail social. Spanish El papel del trabajo social está cambiando como consecuencia de la imposición de políticas neoliberales. Esto crea una insatisfacción general. Se identifican las bases para resistir estas políticas y se explora la posibilidad de que esas bases informen un nuevo paradigma, basado en el rechazo del neoliberalismo en el trabajo social.

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GILLEARD, JOHN S. "Haemonchus contortus as a paradigm and model to study anthelmintic drug resistance." Parasitology 140, no. 12 (September 2, 2013): 1506–22. http://dx.doi.org/10.1017/s0031182013001145.

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SUMMARYAnthelmintic resistance is a major problem for the control livestock parasites and a potential threat to the sustainability of community-wide treatment programmes being used to control human parasites in the developing world. Anthelmintic resistance is essentially a complex quantitative trait in which multiple mutations contribute to the resistance phenotype in an additive manner. Consequently, a combination of forward genetic and genomic approaches are needed to identify the causal mutations and quantify their contribution to the resistance phenotype. Therefore, there is a need to develop genetic and genomic approaches for key parasite species identified as relevant models. Haemonchus contortus, a gastro-intestinal parasite of sheep, has shown a remarkable propensity to develop resistance to all the drugs used in its control. Partly because of this, and partly because of its experimental amenability, research on this parasite has contributed more than any other to our understanding of anthelmintic resistance. H. contortus offers a variety of advantages as an experimental system including the ability to undertake genetic crosses; a prerequisite for genetic mapping. This review will discuss the current progress on developing H. contortus as a model system in which to study anthelmintic resistance.

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SULEIMENOV, Ibragim, Oleg GABRIELYAN, and Yelizaveta VITULYOVA. "Dialectics of Scientific Revolutions from the Point of View of Innovations Theory." WISDOM 24, no. 4 (December 25, 2022): 25–35. http://dx.doi.org/10.24234/wisdom.v24i4.913.

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It is shown that the difficulties that appear during attempts to uncover the mechanisms of changing of scientific paradigms can be overcome by consistent application of the apparatus of dialectics and by the interpretation of science as a social institution that produces intangible assets. This interpretation demonstrates analogy between T. Kuhn’s theory of changing scientific paradigms and the theory of innovation cycles, which goes back to the works of J. Schumpeter. The fact allows one to consider the production of intangible assets by the methods of institutional economics. The basic dialectical contradiction in this interpretation is the contradiction between the innovativeness of a set of ideas that form a new paradigm and ensure the systematic generation of intangible assets, and its liquidity. The liquidity of intangible assets is primarily determined by the extent to which society is ready to accept new ideas and views. The resolution of the identified contradiction is carried out through a cyclical change in resistance to innovation. The period of dominance of a certain paradigm ends when it exhausts the potential of its development, which determines the finiteness of the life cycle of any scientific paradigm, just as the life cycle of any innovation is finite.

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Lahiry, Sandeep, Rajesh Ramalingam, Krunal Dalal, Ashwini Pawar, Yashpal Chugh, Alap Gandhi, and Bhavesh Kotak. "Tackling AMR crisis in India: Changing paradigm." Asian Journal of Medical Sciences 11, no. 6 (November 1, 2020): 129–37. http://dx.doi.org/10.3126/ajms.v11i6.29427.

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Antimicrobial resistance (AMR) is an important public health concern globally. For India, undoubtedly, AMR has had profound impact on its health & socioeconomic parameters. Several hospital and community-based surveys have indicated alarming rise in incidence of multidrug resistant microbes, especially ‘superbugs’, having direct links with antibiotic use/misuse. Additionally, paucity in data with regards to quantification of AMR crisis & its determinants has been concerning. However, the national commitment to address AMR has steadily increased of late, with an oft-restated realization – it is time to act. Recent initiatives like National Policy for Containment of AMR (2011), Chennai Declaration (2012), Anti-microbial Resistance Surveillance and Research Network (2013), The Red Line Campaign (2016), National Action Plan (NAP) for AMR (2017), ICMR Treatment Guidelines for Antimicrobial Use in Common Syndromes (2019) are promising measures expected to have positive impact on both clinical and economic outcome in India. This paper provides a snapshot of major strategies proposed in recent years, including educational and awareness initiatives, infection control guidelines, audit and feedback, antimicrobial stewardship, surveillance projects etc. It also identifies technical challenges & opportunities for improved AMR mitigation in India.

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Saha, Suranjit Kumar. "IN SEARCH OF A THEORY FOR SUPPORTING RESISTANCE TO PREDATORY NEOLIBERALISM IN THE 21ST CENTURY." Revista Políticas Públicas 18 (August 5, 2014): 115. http://dx.doi.org/10.18764/2178-2865.v18nep115-137.

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This text deals with the search of fundamentals to the south-south research about the key-problems of the emerging configurations of a new and multipolar world order. Highlights two main questions: if the neoliberal orthodox in its various forms is to be effectively challenged and if the predatory policies resulting from it should be reverted. It starts ofthe perspective that is necessary an alternative paradigm of development, clearly enounced, which reinforces the national identity in Latin America, India and the rest of the world in development. Such paradigm should favour the construction of mix and inclusives cultures able to create the sense of solidarity among great masses located in extensive areas with the objective to unblock, free and mobilize resistance against the predatory neoliberalism in the 21st centuryKeywords: Neoliberalismo, resistance, national identityEM BUSCA DE UMA TEORIA PARA AJUDAR A RESISTÊNCIA AO NEOLIBERALISMO PREDATÓRIO NO SÉCULO XXIResumo: O texto trata da busca de fundamentos para a pesquisa sul-sul sobre os problemas- chave das configurações emergentes de uma nova e multipolar ordem mundial. Destaca duas questões centrais : se o neoliberal ortodoxo em suas formas variadas é para ser efetivamente desafiado e se as políticas predatórias daí resultantes devem ser revertidas. Parte da perspectiva de que é necessário um paradigma alternativo de desenvolvimento, claramente enunciado, que reforce aidentidade nacional na América Latina, Índia e o resto do mundo em desenvolvimento. Tal paradigma deve favorecer a construção de culturas mistas e inclusivas capazes de criar senso de solidariedade entre grandes massas situadas em extensas áreas com vista a desbloquear, libertar e mobilizar resistência contra o neoliberalismo predatório no século XXIPalavras-chave: Neoliberalismo, resistência, identidade nacional

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Vukotic, Veselin. "Economic freedom and new economic paradigm." Panoeconomicus 55, no. 1 (2008): 115–28. http://dx.doi.org/10.2298/pan0801115v.

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Are economic freedoms going to clear our way to prosperity? Is the growth of economic freedoms our path to prosperity? Is it in the base of the new understanding of development? If yes, what will necessarily have to be changed in the economic practice of every country and whole world in general? What will be changed in economic theory? What are potential consequences of an attempt to offer resistance to the new concept of development? These are just some of the questions discussed in this paper, whereas the starting point is the economy and economic development of Montenegro.

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Tolmasky, Marcelo, E. "Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm." Frontiers in Bioscience 5, no. 1 (1999): d20. http://dx.doi.org/10.2741/tolmasky.

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De Santis, Sara, Cecilia Monaldi, Manuela Mancini, Samantha Bruno, Michele Cavo, and Simona Soverini. "Overcoming Resistance to Kinase Inhibitors: The Paradigm of Chronic Myeloid Leukemia." OncoTargets and Therapy Volume 15 (January 2022): 103–16. http://dx.doi.org/10.2147/ott.s289306.

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Haugaard, Christoffer, and Kristian Sandberg. "Resistance in cognitive therapy: An analysis of paradigm and contemporary practice." Nordic Psychology 60, no. 1 (January 2008): 24–42. http://dx.doi.org/10.1027/1901-2276.60.1.24.

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Sharma, Surinder K., and Sham S. Goyal. "Progress in Plant Salinity Resistance Research: Need for an Integrative Paradigm." Journal of Crop Production 7, no. 1-2 (January 20, 2003): 387–407. http://dx.doi.org/10.1300/j144v07n01_15.

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Qayyum, Shariq, and Asad U. Khan. "Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance." MedChemComm 7, no. 8 (2016): 1479–98. http://dx.doi.org/10.1039/c6md00124f.

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Rotter, V. "42: The mutant p53-cancer stem cells and drug resistance paradigm." European Journal of Cancer 50 (July 2014): S11. http://dx.doi.org/10.1016/s0959-8049(14)50042-1.

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