Academic literature on the topic 'Réponse immunitaire – Recherche – Analyse'
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Journal articles on the topic "Réponse immunitaire – Recherche – Analyse"
Leclair, Lucie, and Stéphane Depil. "Les lymphocytes T CD4+ jouent un rôle majeur dans la réponse immunitaire antitumorale." médecine/sciences 37, no. 6-7 (June 2021): 671–73. http://dx.doi.org/10.1051/medsci/2021075.
Full textBelzeaux, R. "Comment les gènes s’expriment au cours de la réponse aux antidépresseurs ?" European Psychiatry 29, S3 (November 2014): 555. http://dx.doi.org/10.1016/j.eurpsy.2014.09.359.
Full textHasan, Milena. "Milieu Intérieur." médecine/sciences 35, no. 5 (May 2019): 423–30. http://dx.doi.org/10.1051/medsci/2019077.
Full textClément, Léa, and Barbara Testoni. "Le dysfonctionnement mitochondrial, nouvelle cible thérapeutique pour restaurer les réponses immunitaires épuisées contre le VHB." médecine/sciences 38, no. 2 (February 2022): 223–26. http://dx.doi.org/10.1051/medsci/2022011.
Full textNguyen, Cathy, and Lars Petter Jordheim. "Évaluation de l’immunotoxicité en recherche et dans le cadre du développement biomédical." Biologie Aujourd’hui 216, no. 3-4 (2022): 167–81. http://dx.doi.org/10.1051/jbio/2022020.
Full textCochin, V., M. Gross-Goupil, and A. Ravaud. "Quelle place pour les traitements médicaux avant et après chirurgie es stades localisés ?" Oncologie 20, no. 7-12 (July 2018): 204–10. http://dx.doi.org/10.3166/onco-2019-0024.
Full textAtchessi, Nicole, Megan Striha, Rojiemiahd Edjoc, Christine Abalos, Amanda Lien, Lisa Waddell, Imran Gabrani-Juma, Emily Thompson, and Thomas Dawson. "Réponse immunitaire sérique chez les patients rétablis de la COVID-19 dont le résultat à un test subséquent est positif." Relevé des maladies transmissibles au Canada 47, no. 04 (May 7, 2021): 213–20. http://dx.doi.org/10.14745/ccdr.v47i04a03f.
Full textFusilier, Zoé, and Hermine Ferran. "Allier les capacités anti-tumorales des CAR-T cells aux propriétés des exosomes : une approche innovante pour combattre le cancer." médecine/sciences 36, no. 6-7 (June 2020): 655–58. http://dx.doi.org/10.1051/medsci/2020116.
Full textRiou França, L., and I. Dufaure-Garé. "Le trouble de l’adaptation avec anxiété : recherche de facteurs prédictifs d’une réponse au traitement." European Psychiatry 30, S2 (November 2015): S157—S158. http://dx.doi.org/10.1016/j.eurpsy.2015.09.318.
Full textBenguesmia, Mohamed, Mourad Hamiroune, Aline Chrétien, Françoise Prévot, Christelle Grisez, Jean-Paul Bergeaud, Caroline Lacroux, et al. "Cinétique d’infestation par Haemonchus contortus et réponse d’ovins de races résistante (Martinik Black Belly) et sensible (Lacaune)." Revue d’élevage et de médecine vétérinaire des pays tropicaux 73, no. 2 (June 29, 2020): 123–31. http://dx.doi.org/10.19182/remvt.31874.
Full textDissertations / Theses on the topic "Réponse immunitaire – Recherche – Analyse"
Remot, Aude. "Facteurs immunologiques de la sensibilité néonatale au virus respiratoire syncytial." Electronic Thesis or Diss., Paris, AgroParisTech, 2013. http://www.theses.fr/2013AGPT0022.
Full textThe respiratory syncytial virus (RSV) is the main causative agent of bronchiolitis during infancy. During my thesis, I have characterized the immunological and inflammatory responses in the lung during the neonatal period, at steady-state, during an RSV infection and in response to a vaccine.At steady-state, the lung environment of 6-days-old BALB/c pups is poor in plasmacytoid and conventional dendritic cells (DC), but rich in T lymphocytes expressing GATA-3, suggesting that the Th2 bias of immune responses is an intrinsic feature of the neonatal T lymphocytes. Then, I used a global transcriptomic approach to gain more insight into early events to RSV infection, by comparing pups and adult mice lung responses. I showed that DC recruitment and interferon (IFN) pathways were deficient in infected neonates. Pups treated with the widely used DC growth factor, Flt3-L, prior to RSV infection, have an increased lung DC number and their IFN pathways were partially restored. They were protected against enhanced weight loss and airway inflammation upon reinfection at adult age. Finally, I evaluated a nasal vaccine against RSV (recombinant viral nucleoproteins) in BALB/c pups. I showed that the nature of adjuvants combined with our antigen is a critical component to generate antiviral immune responses that protect against virus replication without exacerbating lung inflammation.Thus, the study of neonatal lung immune responses showed specificities in comparison with those of adults, and allowed me to propose new strategies to prevent RSV disease at this age
Leulier, François. "Analyse génétique de la réponse immunitaire de Drosophila melanogaster." Paris 7, 2003. http://www.theses.fr/2003PA077068.
Full textPerrodou, Emmanuel. "Caractérisation chez la drosophile de molécules de la famille C3 du complément / α2-macroglobuline : Recherche de fonction." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. http://www.theses.fr/2003STR13047.
Full textGirel, Simon. "Modélisation de la réponse Immunitaire T-CD8 : analyse mathématique et modèles multiéchelles." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1250/document.
Full textInfection of an organism by a pathogen triggers the activation of the CD8 T-cells and the initiation of the immune response. The result is a complex program of proliferation and differentiation of the CD8 T-cells, controlled by the evolution of their molecular content. In this manuscript, we present two mathematical models of the CD8 T-cell response. The first one is presented as an impulsive differential equation by which we study the effect of unequal molecular partitioning at cell division on the regulation of molecular heterogeneity. The second one is an agent-based-model that couples the description of a discrete population of CD8 T-cells and that of their molecular content. This model can reproduce the different typical phases of the CD8 T-cell response at both the cellular and the molecular scales. These two studies support the hypothesis that the cell dynamics observed in vivo is a consequence of the molecular heterogeneity structuring the CD8 T-cell population
Levy, Francine. "Analyse de la réponse immunitaire de la drosophile par une approche protéomique." Université Louis Pasteur (Strasbourg) (1971-2008), 2005. https://publication-theses.unistra.fr/public/theses_doctorat/2005/LEVY_Francine_2005.pdf.
Full textSequencing of the genome of the insect model, Drosophila melanogaster, which was completed in 2000, gave a great impetus to post-genomic studies. Investigation of gene and gene product expression can be achieved by transcriptomic and peptidomic/proteomic analyses. These approaches are complementary, however, only the latter allows the study of post-translational modifications, which play an important role in protein functionality, or interactions within protein complexes. Improvements in advanced techniques and bioinformatics provide new tools to characterize proteins involved in physiological processes, such as the immune response of Drosophila. Profiling of the proteins present in the hemolymph of noninfected flies versus flies infected by various microorganisms, was realized by two-dimensional gel electrophoresis and differential isotope labelling of samples. Through this differential analysis, various families of molecules were found to be regulated after the infection. Among them, I identified proteases, protease inhibitors, odorant binding proteins and molecules involved in the binding of lipids, calcium or iron. These molecules are thus new candidates for the further detailed investigation of innate immune mechanisms. In summary, this differential proteomic analysis of the immune response of Drosophila, provides new prospects for the study of proteins regulated during innate immunity
Hauvespre, Caroline. "Analyse des variantes d'épissage de l'Interleukine-4 dans l'étude de la réponse immunitaire." Phd thesis, Université Claude Bernard - Lyon I, 2012. http://tel.archives-ouvertes.fr/tel-00994430.
Full textDefendini, Maria Léria. "Réponse immune à l'apamine : analyse de la restriction génétique, du traitement antigénique et de la spécificité de reconnaissance des anticorps poylclonaux ey monoclonaux." Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX22030.
Full textBain, Christine. "Réponse immunitaire antitumorale dans le modèle de l'adénocarcinome du rein : analyse des mécanismes d'immunosuppression." Lyon 1, 1996. http://www.theses.fr/1996LYO1T275.
Full textChirica, Mircea. "Analyse de la réponse immunitaire anti-tumorale selon les caractéristiques oncogénétiques du cancer colorectal." Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCC082.
Full textColorectal cancers (CRC) develop in the face of an important immune system associated with the intestinal mucosal tissue. Recent advances in tumor immunology have highlighted the role of the immune response in the development, evolution and outcome of cancers. The immune system is thought to actively edit out pre-cancerous tells in tissues as they appear. The quality of the immune response against the tumor has emerged as an important prognostic factor in patients with CRC. Several studies have highlighted the different type of mutations and developmental processes involved in CRC. Some of these mutations are associated with better prognosis (microsatellite instability, MSI) and other with poor outcome (BRAF mutations). Some studies suggest that part of these differential outcomes is driven by the capacity of the tumor to induce a strong immune response. Several other predictive biomarkers have been described including mutations of the KRAS, NRAS, PIK3CA and TP53 genes but their prognostic role remains uncertain. In this study T tells infiltrating the tumor were compared to tells populating the unaffected neighboring mucosal tissue and tells from the peripheral blood. We observed that T tells from the tumor harbor an activated phenotype, with engagement of the NKG2D pathway in CD8 T tells. We show that mucosal and tumor-infiltrating T tells are enriched in NKG2D CD4 T tells, which exhibit cytotoxic functions. Finally, the oncogenic status of the cancer appears to influence the immune response within the tumor as T tell populations differ in MSI compared to MSS tumors and KRAS/NRAS mutated tumors compared to their wild type counterparts
Rutschmann, Sophie. "La Réponse immunitaire humorale de la drosophile : Analyse génétique par mutagenèse systématique à l'EMS." Université Louis Pasteur (Strasbourg) (1971-2008), 2002. http://www.theses.fr/2002STR13042.
Full textInsects are able to mount an efficient host defense to fight against microbial infections. A hallmark of their immune response is the synthesis and release in the hemolymph of a cocktail of antimicrobial peptides. Genetic studies have shown that, in Drosophila, at least two independent pathways control the expression of antimicrobial peptides : the Toll pathway, that regulates the antifungal response, and the imd pathway, that is responsible for the antibacterial response. Nevertheless, some aspects of the regulation of the immune response remained to be elucidated : what are the mechanisms that allow self versus self-non self recognition? What are the components of the activating cascades through hemolymph that signal the presence of pathogens? Which are the members of the imd and Toll pathways that are still unknown? To address these questions, the team in which I accomplished my Ph. D. Thesis realized an EMS (Ethyl Methan Sulfonate) mutagenesis screen of the second chromosome of Drosophila. The aim of this approach is to identify all the genes involved in the regulation of the antimicrobial peptide genes expression. During the mutagenesis screen, we performed more than 27000 crosses and established 7600 fly strains homozygote for mutations carried by the second chromosome. Screening these mutants allowed us to recover several Drosophila lines affected either in the antifungal or the antibacterial response. Analysis of these mutants suggest that the two distinct pathways controlling Drosophila immune response result in the activation of two different Rel proteins : Dif (antifungal pathway) and Relish (antibacterial pathway). The cloning of the genes identified during the screen allowed us to show that the two pathways mediating antimicrobial immune response in Drosophila are largely independant
Book chapters on the topic "Réponse immunitaire – Recherche – Analyse"
SCHÖPFEL, Joachim. "Le paysage des entrepôts de données de recherche en France." In Partage et valorisation des données de la recherche, 39–55. ISTE Group, 2023. http://dx.doi.org/10.51926/iste.9073.ch2.
Full textELIMARI, Nassim, and Gilles LAFARGUE. "Influence du système immunitaire comportemental sur la xénophobie et l’altruisme en temps de pandémie." In Les épidémies au prisme des SHS, 75–82. Editions des archives contemporaines, 2022. http://dx.doi.org/10.17184/eac.5992.
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