Journal articles on the topic 'Remote Control for Personalized Medicine'
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Ivanova, Liliya G., Raisa Y. Tatarintseva, and Dmitry V. Migachev. "Mobile medicine (m-health) a potential reserve of the health care system in crisis situations as exemplified by the coronavirus epidemic COVID-19." Glavvrač (Chief Medical Officer), no. 8 (June 21, 2021): 58–69. http://dx.doi.org/10.33920/med-03-2108-05.
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The article discusses new opportunities to improve the quality of medical care, including for older citizens, when organizing a system of remote dynamic monitoring using methods of preventive, predictive and personalized medicine, including during the epidemic and quarantine events. Objective: to study the benefits of using mobile medicine technologies (m-health) during the fight against coronavirus infection COVID-19. The research method is the analysis and meta-analysis of publications on this topic. The results of the study show the importance of using mobile medicine technologies (m-health) in the structure of medical care for patients at risk and the particular relevance of using these technologies in the development of organizational measures to prevent and control the epidemic, caused, inter alia, by unknown infectious agents.
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Kamath, Sowmya, Karthik Kappaganthu, Stefanie Painter, and Anmol Madan. "Improving Outcomes Through Personalized Recommendations in a Remote Diabetes Monitoring Program: Observational Study." JMIR Formative Research 6, no. 3 (March 21, 2022): e33329. http://dx.doi.org/10.2196/33329.
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Background Diabetes management is complex, and program personalization has been identified to enhance engagement and clinical outcomes in diabetes management programs. However, 50% of individuals living with diabetes are unable to achieve glycemic control, presenting a gap in the delivery of self-management education and behavior change. Machine learning and recommender systems, which have been used within the health care setting, could be a feasible application for diabetes management programs to provide a personalized user experience and improve user engagement and outcomes. Objective This study aims to evaluate machine learning models using member-level engagements to predict improvement in estimated A1c and develop personalized action recommendations within a remote diabetes monitoring program to improve clinical outcomes. Methods A retrospective study of Livongo for Diabetes member engagement data was analyzed within five action categories (interacting with a coach, reading education content, self-monitoring blood glucose level, tracking physical activity, and monitoring nutrition) to build a member-level model to predict if a specific type and level of engagement could lead to improved estimated A1c for members with type 2 diabetes. Engagement and improvement in estimated A1c can be correlated; therefore, the doubly robust learning method was used to model the heterogeneous treatment effect of action engagement on improvements in estimated A1c. Results The treatment effect was successfully computed within the five action categories on estimated A1c reduction for each member. Results show interaction with coaches and self-monitoring blood glucose levels were the actions that resulted in the highest average decrease in estimated A1c (1.7% and 1.4%, respectively) and were the most recommended actions for 54% of the population. However, these were found to not be the optimal interventions for all members; 46% of members were predicted to have better outcomes with one of the other three interventions. Members who engaged with their recommended actions had on average a 0.8% larger reduction in estimated A1c than those who did not engage in recommended actions within the first 3 months of the program. Conclusions Personalized action recommendations using heterogeneous treatment effects to compute the impact of member actions can reduce estimated A1c and be a valuable tool for diabetes management programs in encouraging members toward actions to improve clinical outcomes.
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Zheng, Yuanyuan, Xiaoyu Niu, Qian Wei, Yijing Li, Lifeng Li, and Jie Zhao. "Familial Esophageal Cancer in Taihang Mountain, China: An Era of Personalized Medicine Based on Family and Population Perspective." Cell Transplantation 31 (January 2022): 096368972211291. http://dx.doi.org/10.1177/09636897221129174.
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In the Taihang Mountain areas, known as the “esophageal cancer zone” in China, the incidence of esophageal cancer (ESCA) ranks the first in the country and shows a familial and regional clustering trend. Taihang Mountain areas are located in a mountainous area, with inconvenient transportation, limited living conditions, unbalanced diet, and poor nutrition. Ninety percent of the pathological types of ESCA in Taihang Mountain areas are squamous cell carcinoma, among which the risk factors have not been well understood. These areas are usually remote villages and mountains with low population mobility, large family members, similar environmental factors, and a clear and stable genetic background. Therefore, according to the current situation, second-generation sequencing and multigroup analysis technology are used to analyze the familial ESCA patients; disease-related genetic variation are located; and then disease-related susceptibility genes associated with ESCA are screened and analyzed. Health education, tobacco control, endoscopic screening, and other health management projects for suspected and high-risk patients in areas with a high incidence of ESCA can be carried out for screening and early diagnosis, and the incidence of ESCA in Taihang Mountain areas can be reduced. A comprehensive continuous care pattern based on traditional medical nursing to track, monitor, evaluate, and intervene with patients diagnosed with ESCA to facilitate them with medications guidance, dietary guidance, and timely health problem-solving is established. Furthermore, statistical analysis of epidemiology, gene sequencing, and family genetics information can be performed on patients with ESCA in the Taihang Mountains areas to clarify the relationship between genetic phenotype and genotype during the occurrence of ESCA.
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Fanning, Jason, Amber K. Brooks, Katherine L. Hsieh, Kyle Kershner, Joy Furlipa, Barbara J. Nicklas, and W. Jack Rejeski. "Building on Lessons Learned in a Mobile Intervention to Reduce Pain and Improve Health (MORPH): Protocol for the MORPH-II Trial." JMIR Research Protocols 10, no. 7 (July 19, 2021): e29013. http://dx.doi.org/10.2196/29013.
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Background Engaging in sufficient levels of physical activity, guarding against sustained sitting, and maintaining a healthy body weight represent important lifestyle strategies for managing older adults’ chronic pain. Our first Mobile Health Intervention to Reduce Pain and Improve Health (MORPH) randomized pilot study demonstrated that a partially remote group-mediated diet and daylong activity intervention (ie, a focus on moving often throughout the day) can lead to improved physical function, weight loss, less pain intensity, and fewer minutes of sedentary time. We also identified unique delivery challenges that limited the program’s scalability and potential efficacy. Objective The purpose of the MORPH-II randomized pilot study is to refine the MORPH intervention package based on feedback from MORPH and evaluate the feasibility, acceptability, and preliminary efficacy of this revised package prior to conducting a larger clinical trial. Methods The MORPH-II study is an iteration on MORPH designed to pilot a refined framework, enhance scalability through fully remote delivery, and increase uptake of the daylong movement protocol through revised education content and additional personalized remote coaching. Older, obese, and low-active adults with chronic multisite pain (n=30) will be randomly assigned to receive a 12-week remote group-mediated physical activity and dietary weight loss intervention followed by a 12-week maintenance period or a control condition. Those in the intervention condition will partake in weekly social cognitive theory–based group meetings via teleconference software plus one-on-one support calls on a tapered schedule. They will also engage with a tablet application paired with a wearable activity monitor and smart scale designed to provide ongoing social and behavioral support throughout the week. Those in the control group will receive only the self-monitoring tools. Results Recruitment is ongoing as of January 2021. Conclusions Findings from MORPH-II will help guide other researchers working to intervene on sedentary behavior through frequent movement in older adults with chronic pain. Trial Registration ClinicalTrials.gov NCT04655001; https://clinicaltrials.gov/ct2/show/NCT04655001 International Registered Report Identifier (IRRID) PRR1-10.2196/29013
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Clark, Kevin B. "Smart Device-Driven Corticolimbic Plasticity in Cognitive-Emotional Restructuring of Space-Related Neuropsychiatric Disease and Injury." Life 12, no. 2 (February 4, 2022): 236. http://dx.doi.org/10.3390/life12020236.
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Escalating government and commercial efforts to plan and deploy viable manned near-to-deep solar system exploration and habitation over the coming decades now drives next-generation space medicine innovations. The application of cutting-edge precision medicine, such as brain stimulation techniques, provides powerful clinical and field/flight situation methods to selectively control vagal tone and neuroendocrine-modulated corticolimbic plasticity, which is affected by prolonged cosmic radiation exposure, social isolation or crowding, and weightlessness in constricted operational non-terran locales. Earth-based clinical research demonstrates that brain stimulation approaches may be combined with novel psychotherapeutic integrated memory structure rationales for the corrective reconsolidation of arousing or emotional experiences, autobiographical memories, semantic schema, and other cognitive structures to enhance neuropsychiatric patient outcomes. Such smart cotherapies or countermeasures, which exploit natural, pharmaceutical, and minimally invasive neuroprosthesis-driven nervous system activity, may optimize the cognitive-emotional restructuring of astronauts suffering from space-related neuropsychiatric disease and injury, including mood, affect, and anxiety symptoms of any potential severity and pathophysiology. An appreciation of improved neuropsychiatric healthcare through the merging of new or rediscovered smart theragnostic medical technologies, capable of rendering personalized neuroplasticity training and managed psychotherapeutic treatment protocols, will reveal deeper insights into the illness states experienced by astronauts. Future work in this area should emphasize the ethical role of telemedicine and/or digital clinicians to advance the (semi)autonomous, technology-assisted medical prophylaxis, diagnosis, treatment, monitoring, and compliance of astronauts for elevated health, safety, and performance in remote extreme space and extraterrestrial environments.
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Farris, Alton Brad, Cynthia Cohen, Thomas E. Rogers, and Geoffrey H. Smith. "Whole Slide Imaging for Analytical Anatomic Pathology and Telepathology: Practical Applications Today, Promises, and Perils." Archives of Pathology & Laboratory Medicine 141, no. 4 (February 12, 2017): 542–50. http://dx.doi.org/10.5858/arpa.2016-0265-sa.
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Whole slide imaging (WSI) offers a convenient, tractable platform for measuring features of routine and special-stain histology or in immunohistochemistry staining by using digital image analysis (IA). We now routinely use IA for quantitative and qualitative analysis of theranostic markers such as human epidermal growth factor 2 (HER2/neu), estrogen and progesterone receptors, and Ki-67. Quantitative IA requires extensive validation, however, and may not always be the best approach, with pancreatic neuroendocrine tumors being one example in which a semiautomated approach may be preferable for patient care. We find that IA has great utility for objective assessment of gastrointestinal tract dysplasia, microvessel density in hepatocellular carcinoma, hepatic fibrosis and steatosis, renal fibrosis, and general quality analysis/quality control, although the applications of these to daily practice are still in development. Collaborations with bioinformatics specialists have explored novel applications to gliomas, including in silico approaches for mining histologic data and correlating with molecular and radiologic findings. We and many others are using WSI for rapid, remote-access slide reviews (telepathology), though technical factors currently limit its utility for routine, high-volume diagnostics. In our experience, the greatest current practical impact of WSI lies in facilitating long-term storage and retrieval of images while obviating the need to keep slides on site. Once the existing barriers of capital cost, validation, operator training, software design, and storage/back-up concerns are overcome, these technologies appear destined to be a cornerstone of precision medicine and personalized patient care, and to become a routine part of pathology practice.
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Sokolova, Larisa Vladimirovna, and Alla Vladimirovna Molchanova. "Testing as an Effective Method for Assessing the Quality of Students' Training Achievements." Development of education 4, no. 4 (December 24, 2021): 27–33. http://dx.doi.org/10.31483/r-100655.
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Electronic educational resources including testing, which simplify the process of searching and structuring educational information have been used more often in educational organizations recently. They have made learning more accessible and interesting for students of higher and vocational education institutions, especially in the context of a pandemic. The article provides a brief theoretical justification of the advantages of testing students' academic achievements. The emphasis is placed on the importance of testing as a tool for remote control of students' knowledge, the advantages and disadvantages of using tests both in the educational process of higher and secondary vocational education and in order to control the acquired knowledge are revealed. The study was carried out by the authors on the basis of a comprehensive use of theoretical and empirical methods. The leading theoretical methods were: analysis, generalization, concretization, forecasting, modeling. The work used such empirical methods as conversations, pedagogical observation, questionnaires, expert evaluation, testing, analysis of performance, generalization of pedagogical experience, methods of statistical processing of experimental data. The results presented in the article of the study of testing of students of MPSU at the initial (entrance test), current and final stage of measuring the level of educational achievements of students demonstrated an increase in the values of the effectiveness of testing at all stages of its implementation, an increase in the effectiveness of test control at the intermediate and final stages of the study. The results of the study made it possible to formulate promising directions for the development of problems of testing the quality of education of students of higher and professional education organizations: improving the forms and methods of analysis and interpretation of test results based on the invariant application of test models: improving the psychological and pedagogical orientation of the use of the testing algorithm for personalized learning trajectories in the practice of mass education, etc.
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Schwendicke, F. "Tailored Dentistry: From “One Size Fits All” to Precision Dental Medicine?" Operative Dentistry 43, no. 5 (September 1, 2018): 451–59. http://dx.doi.org/10.2341/18-076-l.
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SUMMARY Over the past 30 years and fueled by both a rapidly evolving understanding of dental diseases and technological advances in diagnostics and therapy, dentistry has been changing dramatically. Managing dental caries and carious lesions had, for nearly a century, encompassed only a small number of basic concepts that were applied to virtually all patients and lesions, namely, invasive removal of any carious tissue regardless of its activity or depth and its replacement with restorative materials (amalgams or crowns for most of the past) or tooth removal and prosthetic replacement. Grounded in a deeper understanding of the disease “caries,” its management—aiming to control the causes of the disease, to slow down or alleviate existing disease, and, only as a last resort, to remove its symptoms using a bur or forceps—has become more complex and diverse. In parallel and at nearly unprecedented speed, our patients are changing, as mirrored by ongoing debates as to the demographic and, with it, the social future of most high-income countries. This article describes how these changes will have a profound future impact on how we practice dental medicine in the future. It will deduce, from both demographic and epidemiologic trends, why there is the need to apply not one but rather the whole range of existing evidence-based concepts in an individualized (personalized) manner, hence increasing the effectiveness and efficiency of dental management strategies, and also describe how these strategies should be tailored according not only to our patients (their age and risk profiles) but also to the specific tooth (or site or lesion).
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Viglianisi, Gaia, Gianluca Martino Tartaglia, Simona Santonocito, Mariacristina Amato, Alessandro Polizzi, Marco Mascitti, and Gaetano Isola. "The Emerging Role of Salivary Oxidative Stress Biomarkers as Prognostic Markers of Periodontitis: New Insights for a Personalized Approach in Dentistry." Journal of Personalized Medicine 13, no. 2 (January 17, 2023): 166. http://dx.doi.org/10.3390/jpm13020166.
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Periodontitis is a multifactorial and infective oral disease that leads to the destruction of periodontal tissues and tooth loss. Although the treatment of periodontitis has improved recently, the effective treatment of periodontitis and the periodontitis-affected periodontal tissues is still a challenge. Therefore, exploring new therapeutic strategies for a personalized approach is urgent. For this reason, the aim of this study is to summarize recent advances and the potential of oxidative stress biomarkers in the early diagnosis and personalized therapeutic approaches in periodontitis. Recently, ROS metabolisms (ROMs) have been studied in the physiopathology of periodontitis. Different studies show that ROS plays a crucial role in periodontitis. In this regard, the reactive oxygen metabolites (ROMs) started to be searched for the measures of the oxidizing capacity of the plasma understood as the total content of oxygen free radicals (ROS). The oxidizing capacity of plasma is a significant indicator of the body’s oxidant state as well as homocysteine (Hcy), sulfur amino acid, which has pro-oxidant effects as it favors the production of superoxide anion. More specifically, the thioredoxin (TRX) and peroxiredoxin (PRX) systems control reactive oxygen species (ROS), such as superoxide and hydroxyl species, to transduce redox signals and change the activities of antioxidant enzymes to remove free radicals. Superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx), among other antioxidant enzymes, change their activity when ROS are produced in order to neutralize free radicals. The TRX system is triggered and transduces redox signals to do this.
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Liu, Yue, and Xia Wang. "Application of Smart Mobile Medical Services in Maternal Health Care Management." Contrast Media & Molecular Imaging 2021 (December 8, 2021): 1–6. http://dx.doi.org/10.1155/2021/6249736.
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In order to standardize the health management of pregnant women, improve the health level of pregnant women, and improve the outcome of pregnancy with the help of the smartphone mobile terminal app, the 100 pregnant women who gave birth in the hospital and participated in the management of the health assistant app were selected as the observation group, and the 100 hospitalized pregnant women who did not participate in the management of the app were selected as the control group. The two groups of pregnant women were compared in their knowledge of health care, compliance of prenatal examination, delivery mode, and follow-up rate. The results showed that the observation group was significantly higher than the control group in the knowledge of health care during pregnancy and perinatal period, the rate of natural childbirth, the compliance rate of prenatal examination, and the follow-up rate. After the system was launched, the number of registered pregnant women reached more than 60% of the total number of pregnant women in the hospital, the number of clicks reached more than 2 million times, the number of clinic settlement accounted for more than 30%, and the interpretation rate of fetal heart rate in outpatient and remote clinics reached more than 20%. The diagnosis and treatment process has been significantly improved, and the implementation effect has reached the expectation. O2O maternal and child service mode has been realized through mobile internet technology. It has been proved that the use of smart mobile terminals in the out-of-hospital health care management of pregnant women not only facilitates medical staff to provide timely personalized medical services for pregnant women but also is convenient for pregnant women to obtain health care knowledge through multiple channels, improve the quality of home health management for pregnant women, and effectively improve the pregnancy outcome.
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van der Kamp, Mattienne, Pamela Reimering Hartgerink, Jean Driessen, Bernard Thio, Hermie Hermens, and Monique Tabak. "Feasibility, Efficacy, and Efficiency of eHealth-Supported Pediatric Asthma Care: Six-Month Quasi-Experimental Single-Arm Pretest-Posttest Study." JMIR Formative Research 5, no. 7 (July 26, 2021): e24634. http://dx.doi.org/10.2196/24634.
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Background Early detection of loss of asthma control can effectively reduce the burden of the disease. However, broad implementation in clinical practice has not been accomplished so far. We are in need of research investigating the operationalization of eHealth pediatric asthma care in practice, which can provide the most potential benefits in terms of adoption, efficiency, and effectiveness. Objective The aim of this study was to investigate the technical and clinical feasibility, including an exploration of the efficacy and cost-efficiency, of an eHealth program implemented in daily clinical pediatric asthma practice. Methods We designed an eHealth-supported pediatric asthma program facilitating early detection of loss of asthma control while increasing symptom awareness and self-management. In the 6-month program, asthma control was monitored by 4 health care professionals (HCPs) by using objective home measurements and the web-based Puffer app to allow timely medical anticipation and prevent treatment delay. Technical feasibility was assessed by technology use, system usability, and technology acceptance. Clinical feasibility was assessed by participation and patient-reported health and care outcomes and via a focus group with HCPs regarding their experiences of implementing eHealth in daily practice. The efficacy and cost-efficiency were explored by comparing pretest-posttest program differences in asthma outcomes (asthma control, lung function, and therapy adherence) and medical consumption. Results Of 41 children, 35 children with moderate-to-severe asthma volunteered for participation. With regard to technical feasibility, the Puffer app scored a good usability score of 78 on the System Usability Scale and a score of 70 for technology acceptance on a scale of 1 to 100. Approximately 75% (18/24) of the children indicated that eHealth helped them to control their asthma during the program. HCPs indicated that home measurements and real time communication enabled them to make safe and substantiated medical decisions during symptom manifestations. With an average time commitment of 15 minutes by patients, eHealth care led to a 80% gross reduction (from €71,784 to €14,018, US $1=€0.85) in health care utilization, 8.6% increase (from 18.6 to 20.2, P=.40) in asthma control, 25.0% increase (from 2.8 to 3.5, P=.04) in the self-management level, and 20.4% improved (from 71.2 to 76.8, P=.02) therapy adherence. Conclusions eHealth asthma care seems to be technically and clinically feasible, enables safe remote care, and seems to be beneficial for pediatric asthma care in terms of health outcomes and health care utilization. Follow-up research should focus on targeted effectiveness studies with the lessons learned, while also enabling individualization of eHealth for personalized health care.
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Usova, E. I., M. V. Ionov, A. S. Alieva, N. G. Avdonina, N. V. Orbeladze, А. A. Khodyreva, A. N. Yakovlev, and N. E. Zvartau. "An integrated approach for very high cardiovascular risk patients. Intermediate results." Russian Journal of Cardiology 27, no. 1 (February 8, 2022): 4839. http://dx.doi.org/10.15829/1560-4071-2022-4839.
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The main objective of secondary prevention measures is to modify key risk factors such as hypertension (HTN) and dyslipidemia in patients with established cardiovascular diseases. Its proper implementation improves both short- and long-term outcomes. Telehealth technologies contributes to faster achievement of target levels and better control of key risk factors.Aim. To establish a comprehensive personalized follow-up framework for patients recovered from an acute coronary syndrome (ACS) that integrates telehealth software and to test its clinical and patient-centered efficacy.Material and methods. The three-month follow-up data of 50 patients (50% of planned enrollees; median age, 57 years [53; 61]; males, 84%) who suffered ACS with myocardial revascularization and low-density lipoprotein cholesterol (LDL-C) at least 2,5 mmol/L at admission. We introduced the simple and save telehealth software for home BP monitoring and lipid profiling. The basic demographic, clinical and laboratory characteristics of patients were described, as well as the changes lipid profile, office and home BP over this period was analyzed. The primary endpoint was a change in LDL-C after 3 months. In addition, we also focused on pharmacological therapy and its dynamics, as well as on remote counseling and patient’ experience with the mobile application.Results. Three months after inclusion, we have noted significant decrease of total cholesterol (-1,67 mmol/L, p<0,0001) and triglycerides (-0,48 mmol/L, p<0,0001). LDL-C changes were also significant (-1,49 mmol/L, adjusted for age, sex and lipid-lowering therapy; p<0,0001) and was associated only with the baseline LDL-C levels (R2=-0,521, p<0,0001). Thirty-nine (78%) patients achieved at least 1 mmol/L drop of LDL-C. Nine of them reached target LDL-C <1,4 mmol/L (and/or a decrease of 50% from baseline). Both high-density lipoprotein cholesterol (-0,48 mmol/l, p=0,348), office and home BP remained mostly unchanged. The proportion of patients with target office BP levels was almost the same (χ2=3,06, p=0,08). Patients who were recommended combined lipid-lowering therapy with cholesterol absorption inhibitor (ezetimibe) were more likely to achieve target LDL-C (χ2=10,95; p=0,003) than those with single agent (67% versus 17%, p=0,003). No differences were found in subgroups of patients in LDL-C reduction. In each patient an average of 15 remote consultations have been performed (from 1 to 54 per patient per 3 moths). Investigators have had to send reminders to 22 patients regarding the need for regular home BP monitoring. The majority of patients treated telehealth software as easy-to-use and user-friendly.Conclusion. According to the 3-month follow-up of patients after ACS who used the framework integrated with telemonitoring and remote counseling, a positive trend in reducing atherogenic lipid levels was demonstrated, but not in office BP. Only a fifth of patients reached the target LDL-C, but the vast majority had target BP. Despite the fact that the program is convenient to use, almost half of participants require additional reminders from physician on self-monitoring.
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Demers, K., A. Rezazadeh Ardabili, B. C. Bongers, M. J. L. Romberg-Camps, A. A. van Bodegraven, D. M. A. E. Jonkers, M. J. Pierik, and L. P. S. Stassen. "P211 Factors associated with estimated cardiorespiratory fitness in patients with Inflammatory Bowel Disease: an exploratory analysis of real-world data." Journal of Crohn's and Colitis 17, Supplement_1 (January 30, 2023): i362—i364. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0341.
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Abstract Background Cardiorespiratory fitness (CRF) as a potential predictor of disease outcome in Inflammatory Bowel Disease (IBD) is understudied, as are risk factors for impaired CRF. Lifestyle interventions focusing on improving CRF may aid in enhancing subjective health, decreasing disability, or even controlling inflammation. The aim of this exploratory study was to investigate risk factors for low estimated CRF (eCRF), as well as the association between eCRF and patient-reported outcomes of IBD in a real-world cohort. Methods A cross-sectional multicenter study was performed between 26 Oct 2021 and 19 Oct 2022, enrolling IBD patients using the remote monitor platform myIBDcoach. Patients reported on disease activity, lifestyle factors, and psychosocial functioning. The four-question Modified Duke Activity Status Index (M-DASI-4Q) was used to assess eCRF, which is a simple screening tool for detecting the risk of impaired CRF as objectively measured with physical exercise tests. The number of positive responses to each of the four questions determines the final score, ranging from 0 to 4. To date, no accepted cut-off for (e)CRF has been identified for patients with IBD. Therefore, an M-DASI-4Q score below the 25th percentile of the study population was exploratively used to define low eCRF. Multivariable logistic regression analysis was performed to identify factors associated with eCRF. Results In total, 410 patients were included, of which 91 (22.2%) had low eCRF. The median M-DASI-4Q score was 3 (IQR 2-4). Low eCRF was characterized by higher age, female sex, higher BMI, and more comorbidities compared to patients with adequate eCRF (Table 1). Patients with low eCRF reported statistically significant higher levels of fatigue and stress, lower subjective disease control, and, remarkably, higher physical activity levels (Table 2). Multivariable logistic regression showed that female sex (adjusted Odds Ratio [aOR] 3.09), higher BMI (aOR 1.06), more comorbidities (aOR 3.77, aOR 8.52), fatigue (aOR 2.26), lower subjective disease control (aOR 0.90), and higher physical activity levels (aOR 2.29) were associated with low eCRF (Table 3). Conclusion In this exploratory study, we described an association between eCRF and patient- and clinical characteristics (sex, BMI, and comorbidities), as well as patient-reported outcomes of IBD (fatigue, and subjective disease control). Future research should investigate the validity of the M-DASI-4Q and determine thresholds for referral for further objective assessment for patients that might benefit from personalized interventions. Furthermore, future studies should further elucidate the interaction between physical activity and (e)CRF in patients with IBD to define recommendations.
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Canaud, Bernard, Charles Chazot, Jeroen Koomans, and Allan Collins. "Fluid and hemodynamic management in hemodialysis patients: challenges and opportunities." Brazilian Journal of Nephrology 41, no. 4 (December 2019): 550–59. http://dx.doi.org/10.1590/2175-8239-jbn-2019-0135.
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Abstract Fluid volume and hemodynamic management in hemodialysis patients is an essential component of dialysis adequacy. Restoring salt and water homeostasis in hemodialysis patients has been a permanent quest by nephrologists summarized by the ‘dry weight’ probing approach. Although this clinical approach has been associated with benefits on cardiovascular outcome, it is now challenged by recent studies showing that intensity or aggressiveness to remove fluid during intermittent dialysis is associated with cardiovascular stress and potential organ damage. A more precise approach is required to improve cardiovascular outcome in this high-risk population. Fluid status assessment and monitoring rely on four components: clinical assessment, non-invasive instrumental tools (e.g., US, bioimpedance, blood volume monitoring), cardiac biomarkers (e.g. natriuretic peptides), and algorithm and sodium modeling to estimate mass transfer. Optimal management of fluid and sodium imbalance in dialysis patients consist in adjusting salt and fluid removal by dialysis (ultrafiltration, dialysate sodium) and by restricting salt intake and fluid gain between dialysis sessions. Modern technology using biosensors and feedback control tools embarked on dialysis machine, with sophisticated analytics will provide direct handling of sodium and water in a more precise and personalized way. It is envisaged in the near future that these tools will support physician decision making with high potential of improving cardiovascular outcome.
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North American Philips Corporation. "Remote control television system using supplementary unit for simplified personalized control." Displays 14, no. 1 (January 1993): 60. http://dx.doi.org/10.1016/0141-9382(93)90025-z.
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Bour, Charline, Adrian Ahne, Gloria Aguayo, Aurélie Fischer, David Marcic, Philippe Kayser, and Guy Fagherazzi. "Global diabetes burden: analysis of regional differences to improve diabetes care." BMJ Open Diabetes Research & Care 10, no. 5 (October 2022): e003040. http://dx.doi.org/10.1136/bmjdrc-2022-003040.
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IntroductionThe current evaluation processes of the burden of diabetes are incomplete and subject to bias. This study aimed to identify regional differences in the diabetes burden on a universal level from the perspective of people with diabetes.Research design and methodsWe developed a worldwide online diabetes observatory based on 34 million diabetes-related tweets from 172 countries covering 41 languages, spanning from 2017 to 2021. After translating all tweets to English, we used machine learning algorithms to remove institutional tweets and jokes, geolocate users, identify topics of interest and quantify associated sentiments and emotions across the seven World Bank regions.ResultsWe identified four topics of interest for people with diabetes (PWD) in the Middle East and North Africa and another 18 topics in North America. Topics related to glycemic control and food are shared among six regions of the world. These topics were mainly associated with sadness (35% and 39% on average compared with levels of sadness in other topics). We also revealed several region-specific concerns (eg, insulin pricing in North America or the burden of daily diabetes management in Europe and Central Asia).ConclusionsThe needs and concerns of PWD vary significantly worldwide, and the burden of diabetes is perceived differently. Our results will support better integration of these regional differences into diabetes programs to improve patient-centric diabetes research and care, focused on the most relevant concerns to enhance personalized medicine and self-management of PWD.
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R, Geethanjali. "Survey on Health Monitoring of Elderly Using IoT." APTIKOM Journal on Computer Science and Information Technologies 2, no. 3 (November 1, 2017): 131–36. http://dx.doi.org/10.11591/aptikom.j.csit.72.
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Most of the elderly citizens are either living by themselves or locked up at home when the family members go to work. Health of the elderly deteriorate gradually with age, but we fail to notice these changes in everyday life. The elderly are at a risk of not being attended immediately in case of emergencies. Internet of Things can be used to alert the family members and health personnel immediately when an abnormality in their health is sensed to prevent such emergencies. It can be used to detect abnormalities in the health condition by monitoring the parameters like heart pulse rate, body temperature, body movement and position, location and raise an alert to take immediate preventive actions. This approach has led to an evolution in the world of medicine. It allows for prognosis of diseases at a much earlier stage using this proactive paradigm compared to the existing retroactive diagnose-and-treat reactive paradigm. It also helps to personalize the treatment options available to meet the specific needs of the person. The early detection of abnormalities in the health condition can help in slowing down the progression of the condition and have everything under control. This article highlights the opportunities and challenges in utilizing the power of Internet of Things for remote healthcare of elderly and chronic patients.
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Alavi, Nazanin, Callum Stephenson, Shadé Miller, Payam Khalafi, Israa Sinan, Danielle Kain, Maggie McDougall, et al. "Developing and Implementing a Web-Based Psychotherapy Program to Address Mental Health Challenges Among Patients Receiving Oncologic and Palliative Care: Protocol for an Open-Label Randomized Controlled Trial." JMIR Research Protocols 10, no. 7 (July 14, 2021): e30735. http://dx.doi.org/10.2196/30735.
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Background The demand for mental health care, particularly for depression and anxiety, is 3-fold greater among patients receiving oncologic and palliative care than for the general population. This population faces unique barriers, making them more susceptible to mental health challenges. Various forms of psychotherapy have been deemed effective in addressing mental health challenges in this population, including supportive psychotherapy, cognitive behavioral therapy, problem-based therapy, and mindfulness; however, their access to traditional face-to-face psychotherapy resources is limited owing to their immunocompromised status, making frequent hospital visits dangerous. Additionally, patients can face hospital fatigue from numerous appointments and investigations or may live in remote areas, which makes commutes both physically and financially challenging. Web-based psychotherapy is a promising solution to address these accessibility barriers. Moreover, web-based psychotherapy has been proven effective in addressing depression and anxiety in other populations and may be implementable among patients receiving oncologic and palliative care. Objective The study will investigate the feasibility and effectiveness of web-based psychotherapy among patients receiving oncologic and palliative care, who have comorbid depression or anxiety. We hypothesized that this program will be a viable and efficacious treatment modality compared to current treatment modalities in addressing depression and anxiety symptoms in this population. Methods Participants (n=60) with depression or anxiety will be recruited from oncology and palliative care settings in Kingston (Ontario, Canada). Participants will be randomly allocated to receive either 8 weeks of web-based psychotherapy plus treatment as usual (treatment arm) or treatment as usual exclusively (control arm). The web-based psychotherapy program will incorporate cognitive behavioral therapy, mindfulness, and problem-solving skills, and homework assignments with personalized feedback from a therapist. All web-based programs will be delivered through a secure platform specifically designed for web-based psychotherapy delivery. To evaluate treatment efficacy, all participants will complete standardized symptomology questionnaires at baseline, midpoint (week 4), and posttreatment. Results The study received ethics approval in February 2021 and began recruiting participants in April 2021. Participant recruitment has been conducted through social media advertisements, physical advertisements, and physician referrals. To date, 11 participants (treatment, n=5; control, n=4; dropout, n=2) have been recruited. Data collection and analysis are expected to conclude by December 2021 and January 2022, respectively. Linear regression (for continuous outcomes) will be conducted with interpretive qualitative methods. Conclusions Our findings can be incorporated into clinical policy and help develop more accessible mental health treatment options for patients receiving oncologic and palliative care. Asynchronous and web-based psychotherapy delivery is a more accessible, scalable, and financially feasible treatment that could have major implications on the health care system. Trial Registration ClinicalTrials.gov NCT04664270; https://clinicaltrials.gov/ct2/show/NCT04664270 International Registered Report Identifier (IRRID) DERR1-10.2196/30735
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van Bakel, B. M. A., S. H. Kroesen, A. Günal, A. Scheepmaker, W. R. M. Aengevaeren, F. F. Willems, R. Wondergem, et al. "Sedentary Behaviour Intervention as a Personalised Secondary Prevention Strategy (SIT LESS) for patients with coronary artery disease participating in cardiac rehabilitation: rationale and design of the SIT LESS randomised clinical trial." BMJ Open Sport & Exercise Medicine 8, no. 2 (May 2022): e001364. http://dx.doi.org/10.1136/bmjsem-2022-001364.
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Patients with coronary artery disease (CAD) are more sedentary compared with the general population, but contemporary cardiac rehabilitation (CR) programmes do not specifically target sedentary behaviour (SB). We developed a 12-week, hybrid (centre-based+home-based) Sedentary behaviour IntervenTion as a personaLisEd Secondary prevention Strategy (SIT LESS). The SIT LESS programme is tailored to the needs of patients with CAD, using evidence-based behavioural change methods and an activity tracker connected to an online dashboard to enable self-monitoring and remote coaching. Following the intervention mapping principles, we first identified determinants of SB from literature to adapt theory-based methods and practical applications to target SB and then evaluated the intervention in advisory board meetings with patients and nurse specialists. This resulted in four core components of SIT LESS: (1) patient education, (2) goal setting, (3) motivational interviewing with coping planning, and (4) (tele)monitoring using a pocket-worn activity tracker connected to a smartphone application and providing vibrotactile feedback after prolonged sedentary bouts. We hypothesise that adding SIT LESS to contemporary CR will reduce SB in patients with CAD to a greater extent compared with usual care. Therefore, 212 patients with CAD will be recruited from two Dutch hospitals and randomised to CR (control) or CR+SIT LESS (intervention). Patients will be assessed prior to, immediately after and 3 months after CR. The primary comparison relates to the pre-CR versus post-CR difference in SB (objectively assessed in min/day) between the control and intervention groups. Secondary outcomes include between-group differences in SB characteristics (eg, number of sedentary bouts); change in SB 3 months after CR; changes in light-intensity and moderate-to-vigorous-intensity physical activity; quality of life; and patients’ competencies for self-management. Outcomes of the SIT LESS randomised clinical trial will provide novel insight into the effectiveness of a structured, hybrid and personalised behaviour change intervention to attenuate SB in patients with CAD participating in CR. Trial registration number NL9263.
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Wei-Po Lee and Jian-Hsin Wang. "A user-centered remote control system for personalized multimedia channel selection." IEEE Transactions on Consumer Electronics 50, no. 4 (November 2004): 1009–15. http://dx.doi.org/10.1109/tce.2004.1362492.
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Costantino, A., M. Vecchi, D. Stocco, D. Noviello, F. S. Conforti, M. Maregatti, and F. Caprioli. "P528 Feasibility, satisfaction and machine learning analysis of factors influencing IBD patients’ trust in the mobile application Care4today IBD." Journal of Crohn's and Colitis 16, Supplement_1 (January 1, 2022): i481—i482. http://dx.doi.org/10.1093/ecco-jcc/jjab232.655.
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Abstract Background The use of telemedicine for the management of patients with Inflammatory Bowel Disease (IBD) has developed quickly over the past few years. In our tertiary referral Centre for IBD we have provided our patients an asynchronous telemedicine service, the App Care4today® IBD (Bepatient, Paris, France). Its main function is the remote monitoring of patients’ symptoms and disease activity (abdominal pain and bowel movements). In addition, it evaluates the quality of life through the EQ-5D-5L questionnaire, it provides information on topics to implement patient education (e.g., smoking), and it allows patients to insert reminders for the therapy. Decision trees (DT) and random forests (RF) are two machine learning (ML) techniques which have been increasingly utilized in the last few years due to their ability to uncover non-linear relationships between covariates and outputs. Methods The aims of our study were to evaluate the app use, satisfaction and trust of IBD patients, and to identify the possible determinants influencing its trust through a ML analysis. From April 26th to May 21st 2021, we have consecutively proposed to all IBD patients (familiar with smartphones and mobile Apps) on biological therapy to download Care4today® IBD. Ease of use, patients’ satisfaction and trust were assessed through a 5 points Likert scale questionnaire adapted on the SUTAQ (Service User Technology Acceptability Questionnaire). ML tools, DT and RF, were used to identify the determinants of patients’ trust. Results Out of 135 enrolled patients (among 151 patients), 87 (64.4%) used the app. Among the patients who compiled the questionnaire (39/87, 44.8%), 92.4% trusted to use the App, 94.9% showed confidence in the monitoring system. On contrast, disagreement (92.4% giving a score <3/5) was expressed for the statement “the Apps can replace my regular health care”. The DT showed that the variable which has influenced the most patients’ trust is the conviction that the App is a tool useful for a better monitoring of their disease by physicians, since it represented the root of the tree which explains the final decision. The RF confirmed that this variable influenced the most patients’ trust with a 15% increase in mean squared error (IncMSE) and 7.10 IncNodePurity. Conclusion More than half of our patients actively used the Care4today IBD App, and more than four of every five of those who responded to the survey proved to be well disposed to its usage, showing a good level of confidence and trust in it. The knowledge of patients’ trust determinants (App utility is the most relevant) is the key point in order to implement the use of these new digital monitoring options, which may help to better manage the disease, through tight control and personalized medicine
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Xu, De Cheng. "Research on the Technology of Intelligent Control Terminal Personalized Heating Heating System." Advanced Materials Research 860-863 (December 2013): 720–23. http://dx.doi.org/10.4028/www.scientific.net/amr.860-863.720.
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This design develop the equipment of centralized heat supply system heating according to need, energy-saving emission reduction technology in the end of indoor.The intelligent control, remote control technology that applied to the indoor heating system, developed with the realization of wireless remote control by mobile phone short message; along with the change of environment temperature and sunshine environment and intelligent control of heat supply; intelligent temperature control, real-time temperature storage, query and other functions of the controller.By controlling the switch on the intelligent control valve, which can be heating, reducing waste according to the actual situation of different users, to achieve the purpose of energy saving.
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Hoptman, Laura. "Remote control." Afterimage 14, no. 8 (March 1, 1987): 20–21. http://dx.doi.org/10.1525/aft.1987.14.8.20.
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Hoptman, Laura. "Remote control." Afterimage 14, no. 8 (March 1, 1987): 20–21. http://dx.doi.org/10.1525/aft.1987.14.8.20.
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Eremenko, A. A., N. V. Rostunova, S. A. Budagyan, and A. V. Kurnosov. "The personalized telemedical system of Obereg for remote patient's monitoring." Messenger of ANESTHESIOLOGY AND RESUSCITATION 17, no. 5 (November 2, 2020): 87–94. http://dx.doi.org/10.21292/2078-5658-2020-17-5-87-94.
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The objective: to assess the potential use of the personalized telemedical system (PTS) of Obereg to ensure monitoring and constant medical control over the state of vital systems of the patient's body in the hospital, during transportation, and in out-of-hospital conditions.Subjects and methods. The Obereg system was tested in leading Russian clinics through simultaneous measurement of vital activity parameters with other standard patient monitoring systems. Comparative evaluation criteria were the following: functionality, measurement accuracy in comparison with stationary systems, reliability of operation, the impact on the operation of PTS of other equipment in the intensive care unit and possible interference, user friendliness for personnel and patients, and verification of communication capabilities based on field experiments. Additional parameters of the system were also evaluated. The need for it by medical units of the Ministry of Health of Russia was estimated.Results. The operability of the system has been confirmed in clinical conditions for patients of various profiles, including the most severe cases; it was found that the functionality of the system and accuracy of measurement met relevant requirements. It was estimated that the total demand for such systems in Russia might amount to 4,250,000 units.Conclusion. The device can be used for individual and group monitoring in intensive care units, in in-patient settings after transfer from intensive care, during rehabilitation for remote monitoring at home, and during patients' transportation to monitor their condition in case of emergency.
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MERCANDO, ANTHONY D. "Remote Control Software." Pacing and Clinical Electrophysiology 16, no. 5 (May 1993): 1060–63. http://dx.doi.org/10.1111/j.1540-8159.1993.tb04580.x.
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Rocchi, Laura, Andrea Faenza, Laura Rambelli, Viviana Guadagnuolo, Giovanni Marconi, Giorgia Simonetti, Cristina Papayannidis, et al. "Ex-Vivo Drug Response Profiling for Precision Medicine Approaches in Acute Myeloid Leukemia with the Open Microwell Microfluidic Platform." Blood 128, no. 22 (December 2, 2016): 1675. http://dx.doi.org/10.1182/blood.v128.22.1675.1675.
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Abstract Background: Patient stratification to match individual patients with the most effective drug treatment is still a major open challenge in cancer care. For instance, cytarabine is the main drug used for AML treatment but 30% of patients fail to respond to this agent. Laboratory developed tests determining ex-vivo cellular response to cytotoxic anticancer drugs have demonstrated good correlations with clinical response, sometimes surpassing the predictive power of molecular and genetic profiling. Standardizing sample processing to remove operator-dependent biases and maintaining live cells in a functional status that closely resembles in-vivo function are major challenges affecting these tests. Here we present the open microwell (OMW) platform, a microfluidic-based system that integrates the entire process of ex-vivo testing of anticancer drug efficacy and enables drug testing in the clinical setting prior to therapy administration. The concept was validated for the first time on 13 AML patients at Sant'Orsola hospital, Italy, showing the possibility to initiate the analysis readily after sample collection, thus minimizing drifts in cell function that typically start occurring within hours from sampling, and provide results in about 24 hours, with a fully-automated system. Methods: 13 refractory, relapsed or newly diagnosed AML patients were enrolled in the study. 2 ml of fresh bone marrow in EDTA and 1 ml of serum blood were collected from each patient. White blood cells (WBC) were separated from bone marrow by standard Ficoll-Paque, suspended in medium additioned with 2% autologous serum and loaded in microfluidic chips featuring 16 microchannels and 1200 microwells/channel (70 μm diameter), open at the bottom end (Fig. 1A-B). After settling down in microwells, cells were stained with CMAC cell tracker, anti-human-CD34/CD45 fluorescently-labeled antibodies and Propidium Iodide (PI) by injecting the reagents in the microchannels. Cytarabine or combination therapies (FLAI-3, FLAI-5, FLA, MEC-4) were then injected in the microchannels and cells were incubated for 24 hours in the system (Fig. 1C). Four channels were used per therapeutic condition, including reference (ref), high (ref x 10) and low (ref/10) dosages plus a non-treated channel as reaction control. Finally, a custom software was used to detect cells in images, classify AML blasts and analyze cell death (Fig. 1D). Drug efficacy was determined by evaluation of both cell depletion and apoptosis induction. Results: We first validated the OMW platform against gold standard (FacsAria flow cytometer) for the detection of tumor cells and measurement of cell viability and apoptosis. Count of blast frequency was carried out on 5 patient samples using anti-CD34/CD45 staining. Results (Fig. 2B) show a correlation between the gold standard and OMW (n=5, R2=0.99, p<0.0001). AML blast viability was carried out on 4 patient samples after 24h drug stimulation and in control situations (vehicle only). OMW and the gold standard (incubation in 96-well plates followed by flow cytometry analysis) showed a correlation (n=4, R2=0.86, p<0.0001, Fig. 2C). We tested the predictive power of the OMW system by comparing ex-vivo drug response analysis with clinical outcomes. The outcome was predicted correctly in 4 out of 4 (100%) patients enrolled in this arm of the study (Fig. 2D). CellPly test score was set as the ratio between the number of dead cells treated at high dosage and control. Equivalent results were obtained using the ref dosage. The test was performed as a blind prospective study for 2 patients and in a retrospective way on residual AML blasts after therapy for 2 patients. In prospective cohort, we assessed therapy response with a bone marrow biopsy performed at day +28 ± 7 from induction/re-induction course. Conclusion: The OMW platform was able to count AML blasts and analyze viability and apoptosis showing high concordance with conventional diagnostics represented by flow cytometry. The assay requires 30 μl of bone marrow sample and simple manual pre-processing. Profiling of patient response to specific drugs or combination is provided within 24h. These features make the OMW platform suitable for bedside analysis, to evaluate drug activity on tumor cells within a heterogeneous sample and promptly guide personalized treatment in hematologic malignancies, with a first proof achieved on AML patients. LRo and AF equally contributed. Disclosures Rocchi: CellPly S.r.l.: Employment. Faenza:CellPly S.r.l.: Employment. Rambelli:CellPly S.r.l.: Employment. Guadagnuolo:CellPly S.r.l.: Employment. Pecorari:CellPly S.r.l.: Employment. Giulianelli:CellPly S.r.l.: Employment. Biscarini:CellPly S.r.l.: Employment. Martinelli:Novartis: Speakers Bureau; Roche: Consultancy, Speakers Bureau; Ariad: Consultancy, Speakers Bureau; BMS: Speakers Bureau; Pfizer: Consultancy, Speakers Bureau; Amgen: Consultancy, Speakers Bureau; MSD: Consultancy; Celgene: Consultancy, Speakers Bureau; Genentech: Consultancy. Guerrieri:CellPly S.r.l.: Equity Ownership. Bocchi:CellPly S.r.l.: Equity Ownership, Membership on an entity's Board of Directors or advisory committees.
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Cullington, Helen, Padraig Kitterick, Lisa DeBold, Mark Weal, Nicholas Clarke, Eva Newberry, and Lisa Aubert. "Have Cochlear Implant, Won't Have to Travel: Introducing Telemedicine to People Using Cochlear Implants." American Journal of Audiology 25, no. 3S (October 2016): 299–302. http://dx.doi.org/10.1044/2016_aja-16-0018.
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Purpose This research note describes a planned project to design, implement, and evaluate remote care for adults using cochlear implants and compare their outcomes with those of individuals following the standard care pathway. Method Sixty people with cochlear implants will be recruited and randomized to either the remote care group or a control group. The remote care group will use new tools for 6 months: remote and self-monitoring, self-adjustment of device, and a personalized online support tool. The main outcome measure is patient empowerment, with secondary outcomes of stability in hearing and quality of life, patient and clinician preference, and use of clinic resources. Conclusion The clinical trial ends in summer 2016. Remote care may offer a viable method of follow-up for some adults with cochlear implants.
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Aharon, Keren B., Avital Gershfeld-Litvin, On Amir, Irene Nabutovsky, and Robert Klempfner. "Improving cardiac rehabilitation patient adherence via personalized interventions." PLOS ONE 17, no. 8 (August 29, 2022): e0273815. http://dx.doi.org/10.1371/journal.pone.0273815.
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Objectives Despite documented benefits and physicians’ recommendations to participate in cardiac rehabilitation (CR) programs, the average dropout rate remains between 12–56%. This study’s goal was to demonstrate that using personalized interventions can significantly increase patient adherence. Method Ninety-five patients (ages 18–90) eligible for the CR program were randomly recruited and received personalized interventions using the Well-Beat system. Adherence levels were compared to those of a historical control group. The Well-Beat system provided Sheba CR Health Care Provider (HCP) guidelines for personalized patient-therapist dialogue. The system also generated ongoing personalized text messages for each patient sent twice a week and related each patient’s dynamic profile to their daily behavior, creating continuity, and reinforcing the desired behavior. Results A significant increase in patient adherence to the CR program: Three months after initiation, 76% remained active compared to the historical average of 24% in the matched control group (log-rank p-value = 0.001). Conclusions Using an Artificial Intelligence (AI)-based engine that generated recommendations and messages made it possible to improve patient adherence without increasing HCP load, benefiting all. Presenting customized patient insights to the HCP and generating personalized communications along with action motivating text messages can also be useful for remote care.
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Preiser, Jean-Charles, Olivier Lheureux, and Danielle Prevedello. "A Step Toward Personalized Glycemic Control*." Critical Care Medicine 46, no. 6 (June 2018): 1019–20. http://dx.doi.org/10.1097/ccm.0000000000003107.
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Agusti, Alvar, Joaquim Gea, and Rosa Faner. "Biomarkers, the control panel and personalized COPD medicine." Respirology 21, no. 1 (July 14, 2015): 24–33. http://dx.doi.org/10.1111/resp.12585.
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Kachmar, Oleh, Anna Kushnir, Bohdana Fedchyshyn, Julián Cristiano, John O’Flaherty, Kjetil Helland, Gordon Johnson, and Domenec Puig. "Personalized balance games for children with cerebral palsy: A pilot study." Journal of Pediatric Rehabilitation Medicine 14, no. 2 (June 25, 2021): 237–45. http://dx.doi.org/10.3233/prm-190666.
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PURPOSE: To assess the changes in balance function in children with cerebral palsy (CP) after two weeks of daily training with personalized balance games. METHODS: Twenty-five children with CP, aged 5 to 18 years were randomly selected for experimental or control groups. Over a period of two weeks, all participants received 8–9 game sessions for 15–20 minutes, totaling 150–160 minutes. The experimental group used personalized balance games available from the GAmification for Better LifE (GABLE) online serious gaming platform. Children from the control group played Nintendo Wii games using a handheld Wii Remote. Both groups received the same background treatment. Recorded outcome measures were from a Trunk Control Measurement Scale (TCMS), Timed Up & Go Test (TUG), Center of Pressure Path Length (COP-PL), and Dynamic Balance Test (DBT). RESULTS: After two weeks of training in the experimental group TCMS scores increased by 4.5 points (SD = 3.5, p< 0.05) and DBT results increased by 0.88 points (IQR = 1.03, p< 0.05) while these scores did not change significantly in the control group. Overall, TUG and COP-PL scores were not affected in either group. CONCLUSION: This study demonstrates improvement of balancing function in children with CP after a two-week course of training with personalized rehabilitation computer games.
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Shi, Chun Yang. "Application of Wireless Communication Technology Based on Visual C + + in Smart Home." Applied Mechanics and Materials 651-653 (September 2014): 2008–12. http://dx.doi.org/10.4028/www.scientific.net/amm.651-653.2008.
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The smart home is a kind of brand-new life concept, with the development of science and technology, people’s pursuit of quality of life is more and more high. The living concept "Safe and comfort, health and environmental protection, natural and harmony, people-oriented, efficient and convenient, personalized" has been received by most. With the rapid development of 4G networks, the Internet access technology based on mobile terminal and the family high-speed broadband network connectivity built a high-speed communication platform for the control and application of intelligent household life, and the high-speed platform created the condition for developing the richer remote intelligent household control application. Smart phones carry-on become bonds connecting smart home system and high-speed mobile communications platform, and remote control for smart phone will bring our life into a new field.
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Flamant, Mathurin, and Xavier Roblin. "Inflammatory bowel disease: towards a personalized medicine." Therapeutic Advances in Gastroenterology 11 (January 1, 2018): 1756283X1774502. http://dx.doi.org/10.1177/1756283x17745029.
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The management of inflammatory bowel disease (IBD) has been transformed over the last two decades by the arrival of tumor necrosis factor (TNF) antagonist agents. Recently, alternative drugs have been approved, directed at leukocyte-trafficking molecules (vedolizumab) or other inflammatory cytokines (ustekinumab). New therapeutics are currently being developed in IBD and represent promising targets as they involve other mechanisms of action (JAK molecules, Smad 7 antisense oligonucleotide etc.). Beyond TNF antagonist agents, these alternative drugs are needed for early-stage treatment of patients with aggressive IBD or when the disease is resistant to conventional therapy. Personalized medicine involves the determination of patients with a high risk of progression and complications, and better characterization of patients who may respond preferentially to specific therapies. Indeed, more and more studies aim to identify factors predictive of drug response (corresponding to a specific signaling pathway) that could better manage treatment for patients with IBD. Once treatment has started, disease monitoring is essential and remote patient care could in some circumstances be an attractive option. Telemedicine improves medical adherence and quality of life, and has a positive impact on health outcomes of patients with IBD. This review discusses the current application of personalized medicine to the management of patients with IBD and the advantages and limits of telemedicine in IBD.
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Lengauer, Thomas, Nico Pfeifer, and Rolf Kaiser. "Personalized HIV therapy to control drug resistance." Drug Discovery Today: Technologies 11 (March 2014): 57–64. http://dx.doi.org/10.1016/j.ddtec.2014.02.004.
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Jacobi, Judith. "Another Stepping Stone Toward Personalized Glycemic Control*." Critical Care Medicine 48, no. 12 (November 20, 2020): 1893–96. http://dx.doi.org/10.1097/ccm.0000000000004657.
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Ohta, Shoichi, Hideaki Kuzuoka, Mariko Noda, Hirokazu Sasaki, Shiro Mishima, Tadashi Fujikawa, and Tetsuo Yukioka. "Remote support for emergency medicine using a remote-control laser pointer." Journal of Telemedicine and Telecare 12, no. 1 (January 2006): 44–48. http://dx.doi.org/10.1258/135763306775321362.
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Beyar, Rafael, Luis Gruberg, Dan Deleanu, Ariel Roguin, Yaron Almagor, Silviu Cohen, Ganesh Kumar, and Tal Wenderow. "Remote-Control Percutaneous Coronary Interventions." Journal of the American College of Cardiology 47, no. 2 (January 2006): 296–300. http://dx.doi.org/10.1016/j.jacc.2005.09.024.
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Gamboa, Lena, Ali H. Zamat, and Gabriel A. Kwong. "Synthetic immunity by remote control." Theranostics 10, no. 8 (2020): 3652–67. http://dx.doi.org/10.7150/thno.41305.
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West, Adam G., and Peter Fraser. "Remote control of gene transcription." Human Molecular Genetics 14, suppl_1 (April 15, 2005): R101—R111. http://dx.doi.org/10.1093/hmg/ddi104.
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Fainsinger, Robin, Cheryl Nekolaichuk, Lara Fainsinger, Viki Muller, Lisa Fainsinger, Pablo Amigo, Amanda Brisebois, et al. "What is stable pain control? A prospective longitudinal study to assess the clinical value of a personalized pain goal." Palliative Medicine 31, no. 10 (April 24, 2017): 913–20. http://dx.doi.org/10.1177/0269216317701891.
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Background: A universal consensus regarding standardized pain outcomes does not exist. The personalized pain goal has been suggested as a clinically relevant outcome measure. Aim: To assess the feasibility of obtaining a personalized pain goal and to compare a clinically based personalized pain goal definition versus a research-based study definition for stable pain. Design: Prospective longitudinal descriptive study. Measures: The attending physician completed routine assessments, including a personalized pain goal and the Edmonton Classification System for Cancer Pain, and followed patients daily until stable pain control, death, or discharge. Stable pain for cognitively intact patients was defined as pain intensity less than or equal to desired pain intensity goal (personalized pain goal definition) or pain intensity ⩽3 (Edmonton Classification System for Cancer Pain study definition) for three consecutive days with <3 breakthroughs per day. Setting/participants: A total of 300 consecutive advanced cancer patients were recruited from two acute care hospitals and a tertiary palliative care unit. Results: In all, 231/300 patients (77%) had a pain syndrome; 169/231 (73%) provided a personalized pain goal, with 113/169 (67%) reporting a personalized pain goal ⩽3 (median = 3, range = 0–10). Using the personalized pain goal definition as the gold standard, sensitivity and specificity of the Edmonton Classification System for Cancer Pain definition were 71.3% and 98.5%, respectively. For mild (0–3), moderate (4–6), and severe (7–10) pain, the highest sensitivity was for moderate pain (90.5%), with high specificity across all three categories (95%–100%). Conclusion: The personalized pain goal is a feasible outcome measure for cognitively intact patients. The Edmonton Classification System for Cancer Pain definition closely resembles patient-reported personalized pain goals for stable pain and would be appropriate for research purposes. For clinical pain management, it would be important to include the personalized pain goal as standard practice.
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Corno, Antonio. "Remote Control of Pulmonary Blood Flow." Current Cardiology Reviews 3, no. 1 (February 1, 2007): 75–80. http://dx.doi.org/10.2174/157340307779939998.
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Yang, Yuan, Lei Zhang, Ligang Qiang, Jinbing Wang, Yong Zhang, and Xudong Yang. "Research on Palletizing Robot System of Multi - axis Synchronous Control Technology." MATEC Web of Conferences 363 (2022): 01006. http://dx.doi.org/10.1051/matecconf/202236301006.
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Due to the increasing demand for personalized objects, the palletizing packaging of personalized objects has attracted people’s attention. To improve the efficiency of the palletizing system, a palletizing robot based on multi-axis synchronous control technology is proposed in this paper. The robot takes SIMATIC S7 - 1200 PLC as the control core, uses the master command synchronization method to achieve multi-axis synchronization control, and realizes human-computer interaction through PROFINET communication with the touch screen. The multi-sensor is connected with the input and output modules of the PLC, and the review of the grasping object is realized. After the robot is put into use, the flexibility of the palletizing system is improved, the multi-axis synchronous control technology is improved, and the palletizing efficiency of personalized objects is greatly increased.
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Murthy, Rupa. ""Personalized Medicine" : An Innovative Concept." International Journal of Health and Medicine 3, no. 1 (March 30, 2018): 1. http://dx.doi.org/10.24178/ijhm.2018.3.1.01.
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"Personalized Medicine" is about empowering patients to have access to their health information at all times.[1] Empowering implies patient participation through the ongoing process of diagnosis, treatment, and rehabilitation.[1] More importantly, "Personalized Medicine" is about having insights into one's health by being able to visualize, recognize, and take timely corrective action when necessary.[1] As important time may be wasted when looking for information during emergencies resulting in delays and potential medical errors, "Personalized Medicine" offers a way for medical and emergency personnel to immediately obtain accurate, adequate patient information which can be useful, especially if the patient is unable to communicate verbally.[1] By drawing insights from one's health data "Personalized Medicine" enables patients to seek medical care early on and helps them to make the right treatment choices.[1] Storing, retrieving and having access to one's health information, being able to edit and update it when necessary, the ability to draw valuable insight's from one's health data, and the availability of personal health information for quick and easy access by medical personnel and first responders encompasses the concept of “Personalized Medicine”.[1] Microchip technology can make patient information more accessible especially in rural and remote areas.[1] It improves productivity and quality of patient care by providing patients with the relevant information for making better treatment choices and reduces the cost of health care through early diagnosis and treatment.[1] A micro-chipped Personalized Medical Card is a convenient medium to store and retrieve up-to-date health information.[1] By conforming to the standards of privacy and security patient's can have access to their health data without compromising their personal information.[1] A subcutaneous gold-plated microchip insert designed to store vital life saving patient information can be accessed via a smartphone, tablet, or other electronic device from anywhere, anytime.[1] The gold-plated microchip implant is inserted underneath the patient's skin and contained in the subcutaneous layer.[1] The gold-plated microchip has a wireless connection with the device using the state-of-the-art technology and can be paired with a software application that can be readily edited and updated.[1] Therefore, the device saves not only extensive amount of time and effort but also eliminates the need for unnecessary medical tests and treatment.[1] In addition, timely access to updated information can prevent written or spoken patient information which might be lost in transition or translation thereby leading to medication error or wrong treatment.[1] A gold-plated microchip inserted inside the patient's body as a medical device or tagged to a medical device allows patient self-monitoring of vital statistics of specific conditions such as heart disease, diabetes, kidney functions and other metrics associated with different aspects of body function.[1] It acts as a sensor which enables patients to monitor vital parameters of their condition precisely in real time and allows them to lead independent and more productive lives without the need for continuous monitoring or medical supervision.[1] It could potentially be used for investigating structural and functional abnormalities of the heart, liver, kidney, etc.[1] The gold-plated microchip can prove useful in the treatment of conductive disorders such as dysaarythmias and to mitigate symptoms and dysfunction due to myocardial infarction, neurodegenerative disorders, chronic renal disorders, etc.[1] With soaring health care costs the patient's ability to manage their health condition with ease and convenience in the absence of their health care providers empowers patients to enhance their productivity and quality of life, and reduce the cost of care.[1] In addition to patient participation, leveraging technology drives better outcomes and empowers patients to lead a better quality of life which essentially is the true objective of "Personalized Medicine".[1]
"Personalized Medicine" is a patented concept.[1] If you are interested as an investor or partner for "Personalized Medicine" please contact me at dr.rupamurthy@yahoo.com
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Balbay, R., O. F. Aydemir, I. Ozturk, and C. Yesilyaprak. "DAG-MAM AND REMOTE CONTROL SYSTEM (UKEP)." Revista Mexicana de Astronomía y Astrofísica Serie de Conferencias 53 (September 1, 2021): 59–60. http://dx.doi.org/10.22201/ia.14052059p.2021.53.15.
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One of the problems that arise during the DAG-MAM project is the problem of access to the devices. A prototype has been produced for the idea of UKEP which designed to eliminate the deficiency in the DAG-MAM system. It has performed suffciently compared to the devices that can be considered as equivalent in the market.
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Sujana, Ahmad, Ninik Sri Lestari, Rosmalina, Hendi Suhendi, and Mohamad Abduh. "Android Remote Control System using wireless connection." Journal of Physics: Conference Series 2394, no. 1 (December 1, 2022): 012027. http://dx.doi.org/10.1088/1742-6596/2394/1/012027.
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Abstract Remote door lock control using an android based Arduino. where homeowners can lock and unlock by controlling the door lock via a cellphone that is often carried everywhere. So it is hoped that a remote door locking system can be via a smartphone (smartphone) to assist in locking without having to go to the door. In addition to that, the software created is expected to make it easier for homeowners to lock the door without having to go to the door by controlling the door lock using a cellphone to make it easier to open and lock the doors. The method used is the method of data collection and system development methods. The method of data collection is the method of observation and literature study. While the system development method used is the waterfall method. Application control door locks remotely using Arduino based on android were modeled using UML diagrams (Unified Modeling Language). The conclusion of the application made can be used to lock and unlock the door of the house using a cellphone. The creation of an Android-based home door lock application can make it easier for homeowners to open the lock and homeowners are not afraid to lose their house keys. It is expected that the addition of features in the door lock control applications remotely using Arduino based on android not only controls the door lock.
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&NA;. "Remote Control to a Brain Implant Stolen." Journal of Clinical Engineering 30, no. 2 (April 2005): 70. http://dx.doi.org/10.1097/00004669-200504000-00019.
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Busnatu, Ștefan Sebastian, Adelina-Gabriela Niculescu, Alexandra Bolocan, Octavian Andronic, Anca Mihaela Pantea Stoian, Alexandru Scafa-Udriște, Ana Maria Alexandra Stănescu, et al. "A Review of Digital Health and Biotelemetry: Modern Approaches towards Personalized Medicine and Remote Health Assessment." Journal of Personalized Medicine 12, no. 10 (October 5, 2022): 1656. http://dx.doi.org/10.3390/jpm12101656.
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With the prevalence of digitalization in all aspects of modern society, health assessment is becoming digital too. Taking advantage of the most recent technological advances and approaching medicine from an interdisciplinary perspective has allowed for important progress in healthcare services. Digital health technologies and biotelemetry devices have been more extensively employed for preventing, detecting, diagnosing, monitoring, and predicting the evolution of various diseases, without requiring wires, invasive procedures, or face-to-face interaction with medical personnel. This paper aims to review the concepts correlated to digital health, classify and describe biotelemetry devices, and present the potential of digitalization for remote health assessment, the transition to personalized medicine, and the streamlining of clinical trials.
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Livingstone, Katherine, Carlos Celis-Morales, Santiago Navas-Carretero, Rodrigo San-Cristobal, Hannah Forster, Clara Woolhead, Clare O'Donovan, et al. "Personalized Nutrition Advice Reduces Intake of Discretionary Foods and Beverages: Findings From the Food4Me Randomized Controlled Trial." Current Developments in Nutrition 5, Supplement_2 (June 2021): 152. http://dx.doi.org/10.1093/cdn/nzab035_060.
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Abstract Objectives This study aimed to examine changes in intake of discretionary foods and beverages following a personalized nutrition intervention using two national classifications for discretionary foods. Methods Participants were recruited into a 6-month RCT across seven European countries (Food4Me) and were randomized to receive generalized dietary advice (Control) or one of three levels of personalized nutrition advice (based on dietary, phenotypic and genotypic information). Dietary intake from a FFQ was used to determine change between baseline and month 6 in (i) % energy, % contribution to total fat, SFA, total sugars and salt and (ii) contribution (%) made by sweets and snacks to intake of total fat, SFA, sugars and salt from discretionary foods and beverages, defined by Food Standards Scotland (FSS) and the Australian Dietary Guidelines (ADG). Results A total of 1270 adults (40.9 (SD 13.0) years; 57% female) completed the intervention. At month 6, percentage sugars from FSS discretionary items was lower in personalized nutrition vs control (19.0 ± 0.37 vs 21.1 ± 0.65; P = 0.005). Percentage energy (31.2 ± 0.59 vs 32.7 ± 0.59; P = 0.031), % total fat (31.5 ± 0.37 vs 33.3 ± 0.65; P = 0.021), SFA (36.0 ± 0.43 vs 37.8 ± 0.75; P = 0.034) and sugars (31.7 ± 0.44 vs 34.7 ± 0.78; P < 0.001) from ADG discretionary items were lower in personalized nutrition vs control. The % contribution of sugars from sweets and snacks was lower in personalized nutrition vs control (19.1 ± 0.36 vs 21.5 ± 0.63; P < 0.001). At 3 months, effects were consistent for ADG discretionary items, while there was no significant differences in personalized nutrition vs control for FSS discretionary items. Conclusions Compared with generalized dietary advice, personalized nutrition advice achieved greater reductions in intake of discretionary foods and beverages when the classification included all foods high in fat, added sugars and salt. Future personalized nutrition strategies may be used to target intake of discretionary foods and beverages. Funding Sources European Commission Food, Agriculture, Fisheries and Biotechnology Theme of the Seventh Framework Programme for Research and Technological Development [265494]. KML is supported by a NHMRC Emerging Leadership Fellowship (APP1173803).
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De Jager, Elzerie, Justin McCarty, Sarah O’Sullivan, Fatima Rahim, Chibuike Ezeibe, Edward J. Caterson, Adil Haider, Nomi Levy-Carrick, and Eric Goralnick. "Remote Highschool Hemorrhage Control (RHHECON) - Methods of a Randomized Control Trial." Prehospital and Disaster Medicine 34, s1 (May 2019): s92. http://dx.doi.org/10.1017/s1049023x19001912.
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Introduction:Uncontrolled bleeding is a leading cause of preventable death in trauma. The “Stop the Bleed” campaign has trained over 130,000 lay people in the US to act to control bleeding. Current hemorrhage control courses, the most well-known being the American College of Surgeon’s Basic Bleeding Control (ACS B-con) course, require in-person training. Scaling this course nationwide is time and resource intensive. Furthermore, groups have advocated that young people, who are disproportionately affected by physical trauma, be universally trained in hemorrhage control.Aim:Compare the effectiveness of teaching the ACS B-con course to high school (HS) students utilizing three different delivery mechanisms: in-person live, video-recorded, and virtual-live training.Methods:432 students (aged 15-18) will be recruited from two HS settings: 300 from a local HS and 132 from a national online HS platform. Local HS students will be randomized into two arms: a control arm (in-person live training) and virtual training through a pre-recorded lecture. Online HS students will undergo virtual-live training. The primary outcome is correct tourniquet application following training. Secondary outcomes are the acquisition of personal resilience-associated traits using a validated instrument, motivation for further training, and perception of the importance of live training. Tourniquet application data will be assessed using a non-inferiority design using two pairwise comparisons of the intervention arms to the control (in-person). Pre- to post-training survey data will be assessed using paired univariates tests. Sub-analysis of the impact of demographic variables on these relationships will be assessed.Discussion:In addition to integration of cardiopulmonary resuscitation courses into HS curricula, there is momentum to develop effective programs to educate HS students to provide care for the injured and control bleeding before first responders arrive. This trial will help determine the most effective delivery mechanism to teach a hemorrhage control course to HS students at scale.