Academic literature on the topic 'Release orchestration'
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Journal articles on the topic "Release orchestration"
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Petrenko, Volodymyr, and Charna Dibner. "Circadian orchestration of insulin and glucagon release." Cell Cycle 16, no. 12 (May 24, 2017): 1141–42. http://dx.doi.org/10.1080/15384101.2017.1326768.
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Minns, Danielle, Katie Jane Smith, and Emily Gwyer Findlay. "Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents." Mediators of Inflammation 2019 (March 10, 2019): 1–15. http://dx.doi.org/10.1155/2019/8968943.
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Neutrophils are the most abundant leukocytes in peripheral blood and respond rapidly to danger, infiltrating tissues within minutes of infectious or sterile injury. Neutrophils were long thought of as simple killers, but now we recognise them as responsive cells able to adapt to inflammation and orchestrate subsequent events with some sophistication. Here, we discuss how these rapid responders release mediators which influence later adaptive T cell immunity through influences on DC priming and directly on the T cells themselves. We consider how the release of granule contents by neutrophils—through NETosis or degranulation—is one way in which the innate immune system directs the phenotype of the adaptive immune response.
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Karampini, Ellie, Ruben Bierings, and Jan Voorberg. "Orchestration of Primary Hemostasis by Platelet and Endothelial Lysosome-Related Organelles." Arteriosclerosis, Thrombosis, and Vascular Biology 40, no. 6 (June 2020): 1441–53. http://dx.doi.org/10.1161/atvbaha.120.314245.
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Megakaryocyte-derived platelets and endothelial cells store their hemostatic cargo in α- and δ-granules and Weibel-Palade bodies, respectively. These storage granules belong to the lysosome-related organelles (LROs), a heterogeneous group of organelles that are rapidly released following agonist-induced triggering of intracellular signaling pathways. Following vascular injury, endothelial Weibel-Palade bodies release their content into the vascular lumen and promote the formation of long VWF (von Willebrand factor) strings that form an adhesive platform for platelets. Binding to VWF strings as well as exposed subendothelial collagen activates platelets resulting in the release of α- and δ-granules, which are crucial events in formation of a primary hemostatic plug. Biogenesis and secretion of these LROs are pivotal for the maintenance of proper hemostasis. Several bleeding disorders have been linked to abnormal generation of LROs in megakaryocytes and endothelial cells. Recent reviews have emphasized common pathways in the biogenesis and biological properties of LROs, focusing mainly on melanosomes. Despite many similarities, LROs in platelet and endothelial cells clearly possess distinct properties that allow them to provide a highly coordinated and synergistic contribution to primary hemostasis by sequentially releasing hemostatic cargo. In this brief review, we discuss in depth the known regulators of α- and δ-granules in megakaryocytes/platelets and Weibel-Palade bodies in endothelial cells, starting from transcription factors that have been associated with granule formation to protein complexes that promote granule maturation. In addition, we provide a detailed view on the interplay between platelet and endothelial LROs in controlling hemostasis as well as their dysfunction in LRO related bleeding disorders.
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Wang, Xiaogang, William J. Eagen, and Jean C. Lee. "Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles." Proceedings of the National Academy of Sciences 117, no. 6 (January 27, 2020): 3174–84. http://dx.doi.org/10.1073/pnas.1915829117.
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Release of extracellular vesicles (EVs) is a common feature among eukaryotes, archaea, and bacteria. However, the biogenesis and downstream biological effects of EVs released from gram-positive bacteria remain poorly characterized. Here, we report that EVs purified from a community-associated methicillin-resistant Staphylococcus aureus strain were internalized into human macrophages in vitro and that this process was blocked by inhibition of the dynamin-dependent endocytic pathway. Human macrophages responded to S. aureus EVs by TLR2 signaling and activation of NLRP3 inflammasomes through K+ efflux, leading to the recruitment of ASC and activation of caspase-1. Cleavage of pro–interleukin (IL)-1β, pro-IL-18, and gasdermin-D by activated caspase-1 resulted in the cellular release of the mature cytokines IL-1β and IL-18 and induction of pyroptosis. Consistent with this result, a dose-dependent cytokine response was detected in the extracellular fluids of mice challenged intraperitoneally with S. aureus EVs. Pore-forming toxins associated with S. aureus EVs were critical for NLRP3-dependent caspase-1 activation of human macrophages, but not for TLR2 signaling. In contrast, EV-associated lipoproteins not only mediated TLR2 signaling to initiate the priming step of NLRP3 activation but also modulated EV biogenesis and the toxin content of EVs, resulting in alterations in IL-1β, IL-18, and caspase-1 activity. Collectively, our study describes mechanisms by which S. aureus EVs induce inflammasome activation and reveals an unexpected role of staphylococcal lipoproteins in EV biogenesis. EVs may serve as a novel secretory pathway for S. aureus to transport protected cargo in a concentrated form to host cells during infections to modulate cellular functions.
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Almutairi, Jaber, and Mohammad Aldossary. "Modeling and Analyzing Offloading Strategies of IoT Applications over Edge Computing and Joint Clouds." Symmetry 13, no. 3 (March 1, 2021): 402. http://dx.doi.org/10.3390/sym13030402.
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Internet of Things (IoT) is swiftly evolving into a disruptive technology in recent years. For enhancing customer experience and accelerating job execution, IoT task offloading enables mobile end devices to release heavy computation and storage to the resource-rich nodes in collaborative Edges or Clouds. However, how different service architecture and offloading strategies quantitatively impact the end-to-end performance of IoT applications is still far from known particularly given a dynamic and unpredictable assortment of interconnected virtual and physical devices. This paper exploits potential network performance that manifests within the edge-cloud environment, then investigates and compares the impacts of two types of architectures: Loosely-Coupled (LC) and Orchestrator-Enabled (OE). Further, it introduces three customized offloading strategies in order to handle various requirements for IoT latency-sensitive applications. Through comparative experiments, we observed that the computational requirements exerts more influence on the IoT application’s performance compared to the communication requirement. However, when the system scales up to accommodate more IoT devices, communication bandwidth will turn to be the dominant resource and becomes the essential factor that will directly impact the overall performance. Thus, orchestration is a necessary procedure to encompass optimized solutions under different constraints for optimal offloading placement.
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Oliveira, Douglas Souza, Jean Gabriel de Souza, Miryam Paola Alvarez-Flores, Priscila S. Cunegundes, Carlos DeOcesano-Pereira, Aline Maia Lobba, Renata N. Gomes, and Ana Marisa Chudzinski-Tavassi. "Lonomia obliqua Venom Induces NF-κB Activation and a Pro-Inflammatory Profile in THP-1-Derived Macrophage." Toxins 13, no. 7 (June 30, 2021): 462. http://dx.doi.org/10.3390/toxins13070462.
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Envenomation caused by contact with Lonomia obliqua bristles is characterized by pain, an intense systemic proinflammatory reaction and disturbances in the coagulation cascade that can cause severe clinical manifestations and death. However, the role of immune system components in these effects is still poorly understood. In this study, we evaluated the cytotoxic effect of L. obliqua venom on THP-1-derived macrophages and its ability to modulate inflammatory markers, as well as the cytokine and chemokine release profile. Our results show that L. obliqua venom is able to directly exert a potent pro-inflammatory reaction in macrophages, characterized by the activation of the NF-κB transcription factor pathway, the expression of CD80 and CD83, and the release of pro-inflammatory mediators such as TNF-α, IL-1β, IL-6, IL-8 and CXCL10. These results suggest that macrophages can play an important role during the orchestration of the inflammatory response present in envenomation caused by Lonomia obliqua caterpillars.
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Yu, Bin, Yizhe Tang, and Dongsheng Cai. "Brain is an endocrine organ through secretion and nuclear transfer of parathymosin." Life Science Alliance 3, no. 12 (October 21, 2020): e202000917. http://dx.doi.org/10.26508/lsa.202000917.
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This study reports that parathymosin (PTMS) is secreted by hypothalamic stem/progenitor cells (htNSC) to inhibit senescence of recipient cells such as fibroblasts. Upon release, PTMS is rapidly transferred into the nuclei of various cell types, including neuronal GT1-7 cells and different peripheral cells, and it is effectively transferred into neuronal nuclei in various brain regions in vivo. Notably, brain neurons also produce and release PTMS, and because neuronal populations are large, they are important for maintaining PTMS in the cerebrospinal fluid which is further transferable into the blood. Compared with several other brain regions, the hypothalamus is stronger for long-distance PTMS transfer, supporting a key hypothalamic role in this function. In physiology, aging is associated with declines in PTMS production and transfer in the brain, and ptms knockdown in the hypothalamus versus hippocampus were studied showing different contributions to neurobehavioral physiology. In conclusion, the brain is an endocrine organ through secretion and nuclear transfer of PTMS, and the hypothalamus–brain orchestration of this function is protective in physiology and counteractive against aging-related disorders.
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Sharma, Mayank, Maarten Litmaath, Eraldo Silva Junior, and Renato Santana. "Lightweight WLCG Sites." EPJ Web of Conferences 214 (2019): 07019. http://dx.doi.org/10.1051/epjconf/201921407019.
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This article describes a new framework, called SIMPLE, for settingup and maintaining classic WLCG sites with minimal operational efforts and insights needed into the WLCG middleware. The framework provides a single common interface to install and configure any of its supported grid services, such as Compute Elements, Batch Systems, Worker Nodes and miscellaneous middleware packages. It leverages modern container orchestration tools like Kubernetes, Docker Swarm, and confiuration management tools like Puppet, Ansible, to automate deployment of the WLCG services on behalf of a site admin. The framework is modular and extensible by design. Therefore, it is easy to add support for more grid services as well as infrastructure automation tools to accommodate diverse scenarios at different sites. We provide insight into the design of the framework and our efforts towards development, release and deployment of its first implementation featuring CREAM E, TORQUE Batch System and TORQUE based Worker Nodes.
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Sackmann, Erich, and Motomu Tanaka. "Critical role of lipid membranes in polarization and migration of cells: a biophysical view." Biophysical Reviews 13, no. 1 (January 11, 2021): 123–38. http://dx.doi.org/10.1007/s12551-021-00781-1.
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AbstractCell migration plays vital roles in many biologically relevant processes such as tissue morphogenesis and cancer metastasis, and it has fascinated biophysicists over the past several decades. However, despite an increasing number of studies highlighting the orchestration of proteins involved in different signaling pathways, the functional roles of lipid membranes have been essentially overlooked. Lipid membranes are generally considered to be a functionless two-dimensional matrix of proteins, although many proteins regulating cell migration gain functions only after they are recruited to the membrane surface and self-organize their functional domains. In this review, we summarize how the logistical recruitment and release of proteins to and from lipid membranes coordinates complex spatiotemporal molecular processes. As predicted from the classical framework of the Smoluchowski equation of diffusion, lipid/protein membranes serve as a 2D reaction hub that contributes to the effective and robust regulation of polarization and migration of cells involving several competing pathways.
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Ozga, Aleksandra J., Federica Moalli, Jun Abe, Jim Swoger, James Sharpe, Dietmar Zehn, Mario Kreutzfeldt, Doron Merkler, Jorge Ripoll, and Jens V. Stein. "pMHC affinity controls duration of CD8+ T cell–DC interactions and imprints timing of effector differentiation versus expansion." Journal of Experimental Medicine 213, no. 12 (October 31, 2016): 2811–29. http://dx.doi.org/10.1084/jem.20160206.
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During adaptive immune responses, CD8+ T cells with low TCR affinities are released early into the circulation before high-affinity clones become dominant at later time points. How functional avidity maturation is orchestrated in lymphoid tissue and how low-affinity cells contribute to host protection remains unclear. In this study, we used intravital imaging of reactive lymph nodes (LNs) to show that T cells rapidly attached to dendritic cells irrespective of TCR affinity, whereas one day later, the duration of these stable interactions ceased progressively with lowering peptide major histocompatibility complex (pMHC) affinity. This correlated inversely BATF (basic leucine zipper transcription factor, ATF-like) and IRF4 (interferon-regulated factor 4) induction and timing of effector differentiation, as low affinity–primed T cells acquired cytotoxic activity earlier than high affinity–primed ones. After activation, low-affinity effector CD8+ T cells accumulated at efferent lymphatic vessels for egress, whereas high affinity–stimulated CD8+ T cells moved to interfollicular regions in a CXCR3-dependent manner for sustained pMHC stimulation and prolonged expansion. The early release of low-affinity effector T cells led to rapid target cell elimination outside reactive LNs. Our data provide a model for affinity-dependent spatiotemporal orchestration of CD8+ T cell activation inside LNs leading to functional avidity maturation and uncover a role for low-affinity effector T cells during early microbial containment.
Dissertations / Theses on the topic "Release orchestration"
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Víšek, Jakub. "Hromadná orchestrácia v multirepo CI/CD prostrediach." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2021. http://www.nusl.cz/ntk/nusl-445562.
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Multirepo model přístupu ke správě a verzování zdrojového kódu, jež zahrnuje použití mnoha oddělených repozitářů verzovacích systémů, je poslední dobou často zmiňován v odborné literatuře. Jednou z jeho nevýhod je množství zdlouhavých, nezajímavých a repetitivních úkonů, které je nutno provádět při hromadných operacích tvořících transakce napříč těmito repozitáři. Multirepo repozitáře navíc umožňují využití široké škály technologií, což jen umocňuje riziko lidské chyby, ke které při ručně prováděných hromadných operacích může dojít. V rámci této práce je navrženo, implementováno a otestováno řešení pro automatizaci operací prováděných napříč množstvím repozitářů uspořádaných v multirepo modelu, což s nimi uživatelům zlepšuje zkušenost.
Books on the topic "Release orchestration"
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Cohen, Hagit, and Joseph Zohar. The Role of Glucocorticoids in the (Mal)adaptive Response to Traumatic Experience. Edited by Charles B. Nemeroff and Charles R. Marmar. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190259440.003.0038.
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Glucocorticoids (GCs) play a major role in orchestrating the complex physiological and behavioral reactions essential for the maintenance of homeostasis. These compounds enable the organism to prepare for, respond to, and cope with the acute demands of physical and emotional stressors and enable a faster recovery with passage of the threat. A timely and an appropriate GC release commensurate with stressor severity enables the body to properly contain stress responses so as to promote recovery by rapidly restoring homeostasis. Inadequate GC release following stress not only delays recovery by disrupting biological homeostasis but can also interfere with the processing or interpretation of stressful information that results in long-term disruptions in memory integration. A salient example of such an impaired post-traumatic process is post-traumatic stress disorder (PTSD). The findings from recent animal models and translational and clinical neuroendocrine studies summarized in this chapter provide insights shedding light on the apparently contradictory studies of the HPA-axis response to stress. Also included is a review of the basic facts about PTSD and biological data.
Book chapters on the topic "Release orchestration"
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Broadhurst, Laura Lynn. "“Arlen and Harburg and More, Oh My!”." In Adapting The Wizard of Oz, 53–78. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190663179.003.0004.
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The extant sources for the songs in MGM’s The Wizard of Oz— draft lyrics, studio piano-vocal manuscripts, early screenplays, production records, etc.—afford fascinating insight into their creation. Drawing from such largely untapped archival materials, this chapter reveals that each song within the completed film—as an individual, fixed “work”—was created via cumulative authorship along a figurative assembly line. To demonstrate this phenomenon, the evolution of the songs is traced through their successive developmental stages over the course of the film’s three production phases: Pre-Production (genesis of the songs by Harold Arlen and Yip Harburg, arrangement by MGM staff, orchestration by yet different studio personnel, prerecording with orchestra); Production (shoot-to-playback); Post-Production (underscoring by MGM music director Herbert Stothart and staff, continued development of the songs by Stothart and staff, previews and musical editing, final cut released).
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Langston, Nancy. "Endocrine Disruptors in the Environment." In Controversies in Science and Technology. Oxford University Press, 2014. http://dx.doi.org/10.1093/oso/9780199383771.003.0016.
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Since World War II, the production of synthetic chemicals has increased more than 30-fold due to the post-war boom in petrochemical exploration, manufacture, and marketing. The modern chemical industry, now a global enterprise of $2 trillion annually, is central to the world economy, as it generates millions of jobs and consumes vast quantities of energy and raw materials. Today, more than 70,000 different industrial chemicals are synthesized and sold each year (Chandler 2005; McCoy et al. 2006). New technologies and methods for the detection of these synthetic chemicals have drawn increasing attention to the pervasive and persistent presence of hormone-disrupting chemicals in our lives. Hormones—the chemicals that deliver messages throughout the body in order to coordinate physical processes—are deeply sensitive to external interference, and the consequences of such interference are becoming ever more apparent. In July 2005, the Centers for Disease Control (2005) released its Third National Report on Human Exposure to Environmental Chemicals, revealing that industrial chemicals now permeate bodies and ecosystems. Many of these chemicals can interfere with the body’s hormonal signaling system (called the endocrine system), and many persistently resist the metabolic processes that bind and break down natural hormones. More than 358 industrial chemicals and pesticides have been detected in the cord blood of minority American infants (Environmental Working Group 2009). Accumulating data suggests that reproductive problems are also increasing across a broad range of animals, from Great Lakes fish to people. Many researchers suspect that the culprits are environmental exposures to synthetic chemicals that disrupt hormonal signals, particularly in the developing fetus. Endocrine-disrupting chemicals are not rare; they include the most common synthetic chemicals in production, such as many pesticides, plastics, and pharmaceutical drugs. Since World War II, synthetic endocrine-disrupting chemicals have permeated bodies and ecosystems throughout the globe, potentially with profound health and ecological effects (Krimsky 2000). Hormones are chemical signals that regulate communication among cells and organs, thus orchestrating a complex process of fetal development that relies on precise dosage and timing.