Academic literature on the topic 'Relaxin-like factor'

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Journal articles on the topic "Relaxin-like factor"

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Bamberger, Ana-Maria, Richard Ivell, Marga Balvers, Bianca Kelp, Christoph M. Bamberger, Lutz Riethdorf, and Thomas Löning. "Relaxin-Like Factor (RLF)." International Journal of Gynecological Pathology 18, no. 2 (April 1999): 163–68. http://dx.doi.org/10.1097/00004347-199904000-00011.

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Ivell, R. "Biology of the relaxin-like factor (RLF)." Reviews of Reproduction 2, no. 3 (September 1, 1997): 133–38. http://dx.doi.org/10.1530/revreprod/2.3.133.

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Ivell, R. "Biology of the relaxin-like factor (RLF)." Reviews of Reproduction 2, no. 3 (September 1, 1997): 133–38. http://dx.doi.org/10.1530/ror.0.0020133.

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Büllesbach, Erika E., and Christian Schwabe. "Specific, High Affinity Relaxin-like Factor Receptors." Journal of Biological Chemistry 274, no. 32 (August 6, 1999): 22354–58. http://dx.doi.org/10.1074/jbc.274.32.22354.

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Büllesbach, Erika E., Richard Rhodes, Barbara Rembiesa, and Christian Schwabe. "The Relaxin-Like Factor Is a Hormone." Endocrine 10, no. 2 (1999): 167–70. http://dx.doi.org/10.1385/endo:10:2:167.

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Büllesbach, Erika E., and Christian Schwabe. "LGR8 Signal Activation by the Relaxin-like Factor." Journal of Biological Chemistry 280, no. 15 (February 10, 2005): 14586–90. http://dx.doi.org/10.1074/jbc.m414443200.

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Schwabe, Christian, and Erika E. Büllesbach. "The “Hot Wires” of the Relaxin-Like Factor (Insl3)." Annals of the New York Academy of Sciences 1160, no. 1 (April 2009): 93–98. http://dx.doi.org/10.1111/j.1749-6632.2008.03779.x.

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Tomboc, Marlah, Peter A. Lee, Mohamed F. Mitwally, Francis X. Schneck, Mark Bellinger, and Selma F. Witchel. "Insulin-like 3/Relaxin-Like Factor Gene Mutations Are Associated with Cryptorchidism1." Journal of Clinical Endocrinology & Metabolism 85, no. 11 (November 1, 2000): 4013–18. http://dx.doi.org/10.1210/jcem.85.11.6935.

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Cryptorchidism is a common anomaly of male sexual differentiation. Two phases of testicular descent are recognized, transabdominal and inguinoscrotal. With evidence that androgens and Müllerian inhibitory hormone were not completely responsible for testicular descent, the existence of a third testicular hormone mediating testicular descent was postulated. Insulin-like 3 (INSL3) [also known as relaxin-like factor (RLF) and Leydig insulin-like protein (LEY I-L)] is a member of the insulin/relaxin hormone superfamily that is highly expressed in Leydig cells. The phenotype of transgenic mice with targeted deletion of the Insl3 gene was bilateral cryptorchidism with morphological evidence of abnormal gubernacular development. With this implicit evidence that Insl3 mediates testicular descent in mice, we performed mutation detection analysis of the coding regions of the 2 exon INSL3 gene in genomic DNA samples obtained from 145 formerly cryptorchid patients and 36 adult male controls. Single-strand conformational polymorphism analysis was used for the mutation detection studies. Two mutations, R49X and P69L, and several polymorphisms were identified. Both mutations were located in the connecting peptide region of the protein. The frequency of INSL3/RLF gene mutations as a cause of cryptorchidism is low, because only 2 of 145 (1.4%) formerly cryptorchid patients were found to have mutations.
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Tomboc, M. "Insulin-like 3/Relaxin-Like Factor Gene Mutations Are Associated with Cryptorchidism." Journal of Clinical Endocrinology & Metabolism 85, no. 11 (November 1, 2000): 4013–18. http://dx.doi.org/10.1210/jc.85.11.4013.

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Ivell, Richard, and Ross A. D. Bathgate. "Reproductive Biology of the Relaxin-Like Factor (RLF/INSL3)1." Biology of Reproduction 67, no. 3 (September 1, 2002): 699–705. http://dx.doi.org/10.1095/biolreprod.102.005199.

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Dissertations / Theses on the topic "Relaxin-like factor"

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Nasa, Zeyad, and nasa zeyad@med monash edu au. "Characterization of the Rat Relaxin-like Factor Gene." RMIT University. Medical Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080514.100729.

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Relaxin-like factor (RLF), also known as Leydig insulin-like peptide (Ley-I-L) or Insulin 3 (INSL3), is a newly characterized member of the insulin peptide family. Amino acid sequence homology revealed that RLF is more closely related to relaxin than any other insulin-like hormones. The main aim of this thesis was to sequence the rat RLF (Relaxin-like factor) gene and determine the structure and organisation of the gene. Secondly to compare the structural organisation of the rat RLF/JAK3 genomic region with that of the mouse and human, using bioinformatic databases. Thirdly to further investigate the signalling pathways for the RLF receptor, in particular the NFƒÛB pathway. The homology between rat and mouse in the JAK3/RLF region revealed 84.4 % similarity over 1262 bp of DNA sequence, observing that unlike the mouse, the rat RLF promoter is separated from the JAK3 gene by around 700-1000 bp. Similarly in humans, the RLF gene is located around 4 kb downstre am from JAK3. Also Protein kinase A (PKA) was the only signalling pathway which dispalyed major induction and no inhibitory effects were observed through the NFƒÛB signalling pathway.
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Book chapters on the topic "Relaxin-like factor"

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Schwabe, Christian, and Erika E. Büllesbach. "The Relaxin-Like Factor." In Relaxin and the Fine Structure of Proteins, 133–44. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-662-12909-8_16.

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Klonisch, Thomas, Sabine Hombach-Klonisch, Bernd Fischer, and Cuong Hoang-Vu. "Relaxin-Like Factor in the human thyroid." In Relaxin 2000, 361–62. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-017-2877-5_60.

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Ivell, Richard, M. Rasoul Zarreh-Hoshyari-Khah, Ross A. D. Bathgate, Marga Balvers, Paul J. Baker, and Peter J. O’Shaughnessy. "The Relaxin-Like Factor: from gene to physiology." In Relaxin 2000, 327–35. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-017-2877-5_54.

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Tan, Yean Yeow, Nicola F. Dawson, Andrew R. Kompa, Courtney Bond, Antonia Claasz, John D. Wade, Geoffrey W. Tregear, and Roger J. Summers. "Structure-activity relationships of relaxin and relaxin-like factor/insulin 3." In Relaxin 2000, 255–60. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-017-2877-5_43.

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Roche, Peter J., Zeyad Nasa, and Ganeema Tokhi. "Characterization of the rat Relaxin Like Factor/JAK3 gene region." In Relaxin 2000, 357–58. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-017-2877-5_58.

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Klonisch, Thomas, and Sabine Hombach-Klonisch. "Comparative aspects of relaxin and relaxin-like factor (Insulin 3) in the placental trophoblast." In Relaxin 2000, 115–20. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-017-2877-5_14.

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Bathgate, Ross A. D., Nicole Moniac, Bettina Bartlick, Antonia Claasz, Nicola Dawson, Yean-Yeow Tan, John D. Wade, Geoffrey W. Tregear, and Richard Ivell. "The Relaxin-Like Factor (Insulin 3) is highly expressed in the ruminant ovary: A putative ruminant relaxin?" In Relaxin 2000, 349–56. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-017-2877-5_57.

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Hombach-Klonisch, Sabine, Joerg Buchman, Sukhena Sarun, Bernd Fischer, and Thomas Klonisch. "Relaxin-Like Factor is differentially expressed in the normal and neoplastic human mammary gland." In Relaxin 2000, 359–60. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-017-2877-5_59.

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