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Walters, Carl J., and Ray Hilborn. "Exploratory assessment of historical recruitment patterns using relative abundance and catch data." Canadian Journal of Fisheries and Aquatic Sciences 62, no. 9 (September 1, 2005): 1985–90. http://dx.doi.org/10.1139/f05-105.
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Historical apparent recruitment rates can be estimated from time series of relative abundance and catch data using a simple difference equation in conjunction with assumed catchability coefficient and natural survival rate. Simple smoothing and optimal linear state estimation procedures can remove much of the variance in such estimates due to measurement error in relative abundance. The apparent patterns can be helpful to reveal important recruitment changes prior to availability of data for more complex stock assessments, provide checks on recruitments estimated by more complex assessment procedures, and provide warnings about biases in other assessment procedures that might result from using the relative abundance data for model tuning.
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Davey, Matthew G., Gerard Feeney, Heidi Annuk, Maxwell Paganga, Emma Holian, Aoife J. Lowery, Michael J. Kerin, and Nicola Miller. "MicroRNA Expression Profiling Predicts Nodal Status and Disease Recurrence in Patients Treated with Curative Intent for Colorectal Cancer." Cancers 14, no. 9 (April 23, 2022): 2109. http://dx.doi.org/10.3390/cancers14092109.
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Background: Approximately one-third of colorectal cancer (CRC) patients will suffer recurrence. MiRNAs are small non-coding RNAs that play important roles in gene expression. We aimed to correlate miRNA expression with aggressive clinicopathological characteristics and survival outcomes in CRC. Methods: Tumour samples were extracted from 74 CRC patients. MiRNAs were quantified using real-time reverse transcriptase polymerase chain reaction. Descriptive statistics and Cox regression analyses were performed to correlate miRNA targets with clinicopathological and outcome data. Results: Aberrant miR-21 and miR-135b expression correlate with increased nodal stage (p = 0.039, p = 0.022). Using univariable Cox regression analyses, reduced miR-135b (β-coefficient −1.126, hazard ratio 0.324, standard error (SE) 0.4698, p = 0.017) and increased miR-195 (β-coefficient 1.442, hazard ratio 4.229, SE 0.446, p = 0.001) predicted time to disease recurrence. Survival regression trees analysis illustrated a relative cut-off of ≤0.488 for miR-195 and a relative cut-off of >−0.218 for miR-135b; both were associated with improved disease recurrence (p < 0.001, p = 0.015). Using multivariable analysis with all targets as predictors, miR-195 (β-coefficient 3.187, SE 1.419, p = 0.025) was the sole significant independent predictor of recurrence. Conclusion: MiR-195 has strong value in predicting time to recurrence in CRC patients. Additionally, miR-21 and miR-135b predict the degree nodal burden. Future studies may include these findings to personalize therapeutic and surgical decision making.
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Gogate, Anagha, Inkyu Kim, Sandip Ranjan, Amit Kumar, Eros Papademetriou, Hitesh Bhandari, and Ravi Potluri. "Abstract P2-12-09: Correlation between pathologic complete response (pCR), event-free survival (EFS)/disease-free survival (DFS) and overall survival (OS) in neoadjuvant and/or adjuvant (NAdj/Adj) hormone receptor positive (HR+) and human epidermal growth factor receptor-2 negative (HER2-) breast cancer (BC)." Cancer Research 82, no. 4_Supplement (February 15, 2022): P2–12–09—P2–12–09. http://dx.doi.org/10.1158/1538-7445.sabcs21-p2-12-09.
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Abstract Background OS, the “gold standard” endpoint in oncology studies, is challenging to measure in earlier stages of BC because of considerably long survival. Further, during extended patient follow-up, treatment effect on OS can become impacted by multiple factors such as non-malignant causes of death, treatment cross-over, and post-progression treatments, making it difficult to isolate the true treatment effect. As an alternative, surrogate endpoints (SE) such as DFS, EFS, and pCR can be used to ascertain meaningful benefit in true endpoint (TE). While studies have previously explored the association of such SEs with OS in different BC populations, there is a dearth in literature of studies reporting on correlation in the NAdj/Adj settings in the HR+/HER2- BC population. The aim of this study is to conduct a correlation analysis between various SE-TE pairs (DFS/EFS vs OS, pCR vs OS and pCR vs DFS/EFS) in this population, from data reported in studies identified from a systematic literature review (SLR). For each pair of endpoints, both absolute and relative treatment effects were evaluated. Methods An SLR was conducted in NAdj/Adj setting for HR+/HER2- BC to identify studies that reported any two of pCR, DFS/EFS and OS. The search was carried out using MEDLINE, Embase, Cochrane Library databases (2000 onward), four BC-related conference proceedings (2018-2020) and clinical trial registries. Relative treatment effect sizes were quantified in terms of HRs for DFS/EFS and OS, and odds ratios (ORs) for pCR. Absolute treatment effects were analyzed in terms of survival probability of EFS/DFS and OS at landmark time points and pCR rates. A weighted least squares regression analysis was carried out to determine the strength of association between the various TE-SE pairs. The regression analysis was carried out on log scale for relative treatment effects and on linear scale for absolute treatment effects. Pearson correlation coefficient (r) was used to quantify the strength of association; coefficient of determination (R2) was also reported to evaluate goodness-of-fit. Sensitivity analyses were performed by considering linear scale (for relative outcomes only), using inverse of variance as weights, and by removing outliers. Results A total of 135 publications were identified in the SLR. Regression analysis showed that there is a statistically significant positive association (r= 0.91; 95%CI, 0.83-0.96, p <0.0001) between log(HROS) and log (HRDFS/EFS), with R2 = 0.83. The correlation between log (HRDFS/EFS) and log(ORpCR) was not strong (r= 0.24; 95% CI, -0.63-0.84; p, 0.603). Correlation of ORpCR with HROS was not conducted due to inadequate data points (n=3). For the absolute outcomes, landmark DFS/EFS at 1 year and 2 years were each found to be moderately correlated with OS at 4 and 5 years. The correlation between pCR rate and landmark DFS/EFS and OS was not strong. The association between the pairs of the endpoints was consistent across all the sensitivity analyses. Conclusions Results of this regression analysis suggest that relative treatment effect on DFS/EFS is strongly associated with relative treatment effect on OS in HR+HER2- BC and could be used as a surrogate for OS. Correlation analysis for HR(DFS/EFS) vs. HR(OS) and OR(pCR) vs. HR(DFS/EFS)Model# studies# observationsPearson coefficient, r (95% CI)p-valueCoefficient of determination, R2 (95% CI)Slope (95% CI)P-valueHRDFS/EFS vs. HROS24320.91 (0.83-0.96)<0.00010.83 (0.69-0.89)0.99 (0.83-1.16)<.0001ORpCR vs. HRDFS/EFS570.24 (-0.63-0.84)0.60.06 (0-0.47)0.23 (-0.86-1.31)0.6099 Citation Format: Anagha Gogate, Inkyu Kim, Sandip Ranjan, Amit Kumar, Eros Papademetriou, Hitesh Bhandari, Ravi Potluri. Correlation between pathologic complete response (pCR), event-free survival (EFS)/disease-free survival (DFS) and overall survival (OS) in neoadjuvant and/or adjuvant (NAdj/Adj) hormone receptor positive (HR+) and human epidermal growth factor receptor-2 negative (HER2-) breast cancer (BC) [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-12-09.
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EI Hasnaoui, A., and J. P. Jais. "Study and Applications of an Informational Measure of Dependence in Survival Models." Methods of Information in Medicine 31, no. 04 (1992): 275–83. http://dx.doi.org/10.1055/s-0038-1634886.
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Abstract:In survival models, when the factor of interest is a continuous variable or is expressed through a group of several variables, the classical measures of risk, i. e. relative risk and odds ratio, are not appropriate and there is no standard measure of dependence between survival and the considered factor. The Information Gain has been proposed by Linfoot (1957) and Kent (1983), giving any parametric model as a generalization of the squared product-moment correlation coefficient of the linear regression model with normal errors. By using simulation methods, we studied the statistical properties of the information gain as a measure of dependence, in the particular case of survival regression models. We suggest several efficient applications of this informational concept to some classical problems of regression analysis and prognostic analysis. Our ideas are illustrated through an example on the prognosis of idiopathic dilated cardiomyopathy.
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Muhammed, Sadik. "Comparison of Some Biological Parameters between Young Grass Carp, Ctenopharyngodon idella (Valenciennes, 1884) fed on Artificial Diet and Alfalfa inEarthen Ponds at Basrah, Iraq." Biological and Applied Environmental Research 6, no. 1 (January 1, 2022): 1–13. http://dx.doi.org/10.51304/baer.2022.6.1.1.
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The current study aims to compare the relationships of some biological parameters of young grass carp, Ctenopharyngodon idella (Valenciennes, 1844) fed on artificial diet and alfalfa in earthen ponds. These parameters included length-weight relationship, relative length and weight of the alimentary canal, condition factor and survival rate. Results of lengthweight relationship showed that no significant differences (P>0.05) were recorded for the t-test for the ideal value of 3 for fishes fed on artificial diet or alfalfa plant. The condition factor of young grass carp fed on artificial diet ranged between 0.021 to 1.074, while for fishes fed on alfalfa plant was 0.023 to 1.270 for allometric and Fulton’s condition factor, respectively. Also, there was no significant difference (P>0.05) for fishes fed on both diets in all biological parameters, the relative length of the alimentary canal for fishes fed on artificial diet (1.65) and on alfalfa plant (1.69), while the relative weight of the alimentary canal were 0.0285 and 0.0218 for fishes fed on both diets, respectively. Results also showed that the Zihler coefficient were 7.43 and 7.62, respectively. The survival rate was 100% for both treatments.
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Oh, Joonmi, Roland G. Henry, Andrea Pirzkall, Ying Lu, Xiaojuan Li, Isabelle Catalaa, Susan Chang, William P. Dillon, and Sarah J. Nelson. "Survival analysis in patients with glioblastoma multiforme: Predictive value of choline-to-n-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume." Journal of Magnetic Resonance Imaging 19, no. 5 (2004): 546–54. http://dx.doi.org/10.1002/jmri.20039.
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Puig, Josep, Carles Biarnés, Pepus Daunis-i-Estadella, Gerard Blasco, Alfredo Gimeno, Marco Essig, Carme Balaña, et al. "Macrovascular Networks on Contrast-Enhanced Magnetic Resonance Imaging Improves Survival Prediction in Newly Diagnosed Glioblastoma." Cancers 11, no. 1 (January 14, 2019): 84. http://dx.doi.org/10.3390/cancers11010084.
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A higher degree of angiogenesis is associated with shortened survival in glioblastoma. Feasible morphometric parameters for analyzing vascular networks in brain tumors in clinical practice are lacking. We investigated whether the macrovascular network classified by the number of vessel-like structures (nVS) visible on three-dimensional T1-weighted contrast–enhanced (3D-T1CE) magnetic resonance imaging (MRI) could improve survival prediction models for newly diagnosed glioblastoma based on clinical and other imaging features. Ninety-seven consecutive patients (62 men; mean age, 58 ± 15 years) with histologically proven glioblastoma underwent 1.5T-MRI, including anatomical, diffusion-weighted, dynamic susceptibility contrast perfusion, and 3D-T1CE sequences after 0.1 mmol/kg gadobutrol. We assessed nVS related to the tumor on 1-mm isovoxel 3D-T1CE images, and relative cerebral blood volume, relative cerebral flow volume (rCBF), delay mean time, and apparent diffusion coefficient in volumes of interest for contrast-enhancing lesion (CEL), non-CEL, and contralateral normal-appearing white matter. We also assessed Visually Accessible Rembrandt Images scoring system features. We used ROC curves to determine the cutoff for nVS and univariate and multivariate cox proportional hazards regression for overall survival. Prognostic factors were evaluated by Kaplan-Meier survival and ROC analyses. Lesions with nVS > 5 were classified as having highly developed macrovascular network; 58 (60.4%) tumors had highly developed macrovascular network. Patients with highly developed macrovascular network were older, had higher volumeCEL, increased rCBFCEL, and poor survival; nVS correlated negatively with survival (r = −0.286; p = 0.008). On multivariate analysis, standard treatment, age at diagnosis, and macrovascular network best predicted survival at 1 year (AUC 0.901, 83.3% sensitivity, 93.3% specificity, 96.2% PPV, 73.7% NPV). Contrast-enhanced MRI macrovascular network improves survival prediction in newly diagnosed glioblastoma.
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Jan, Shyh-Shyan, Dai-Qing Yang, and Rommanee Thammasena. "Effect of Antimicrobial Peptides on the Growth and Immunity of Swamp Eels." Journal of Aquaculture and Fish Health 10, no. 2 (May 28, 2021): 137. http://dx.doi.org/10.20473/jafh.v10i2.22625.
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This study aimed to investigate the effect of different levels of antimicrobial peptides (AMPs) supplementation in the diet feed on growth performance, survival rate, biochemical parameters in swamp eels. Healthy fishes were randomly assigned to five groups feeding with different supplementation of AMPs (0, 200, 400, 600, or 800 mg/kg) in diets for 68 days. Results showed that relative weight gain, feed coefficient and survival rate were significantly (p<0.05) increased by supplementation of AMPs in feed. Level of protein (TP), triglyceride TG, alanine transaminase (ALT), alkaline phosphate (ALP), acid phosphate (ACP), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) in the serum were significantly (p<0.05) improved in all AMPs treatments, while no significant difference was found between the control and AMPs 200 mg/kg. AMPs supplementation significantly enhanced (p<0.05) the survival rate and immune protection in swamp eels after challenged with Aeromonas hydrophila compared to the control group and eels fed with AMPs 800 mg/kg had the highest survival rate and immune protection (32.50 and 85.71%, respectively). The diets containing AMPs enhanced the survival rate, immune ability, and antioxidant capacity in swamp eels, indicate that an appropriate dosage of AMPs can be used as a potential alternative to antibiotics in swamp eels.
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Giannarelli, D., E. Bria, F. Cuppone, M. Ciccarese, C. Nisticò, P. Carlini, M. Milella, V. Lorusso, E. Terzoli, and F. Cognetti. "Three-year disease-free survival (DFS) as surrogate end-point for predicting five-year overall survival (OS) benefit in adjuvant taxane-based chemotherapy for breast cancer (BC): Analysis of 10 randomized clinical trials (RCTs)." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 584. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.584.
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584 Background: The issue regarding the eventual correlation between DFS at earlier follow-up (i.e. 3-yrs) with 5-yrs OS has not actually been explored in trials addressing the role of taxanes in BC. All RCTs in which patients were randomized to receive a standard or a taxane-based regimen for early BC were analyzed to evaluate this topic. Methods: All phase III trials with at least 60 month follow-up were considered eligible. The correlation has been explored according to a linear regression model considering both each single outcome pair (DFS/OS) for all arms (extracted by curves), their differences, and each outcome Hazard Ratio (HR) or calculated Relative Risk (RRs), following 2 steps: 1) correlation between 5-yrs DFS and OS (to confirm the evidence); 2) correlation between 3-yrs DFS and 5-yrs OS (predictive role). The correlation was estimated according to Pearson (r) and R2 coefficients (parametric) and Spearman (Rho) coefficient (non- parametric). A model to calculate the target sample size to determine 5-yrs OS benefit of 3%, 5% and 7%, respectively, was calculated as well. Results: Ten RCTs (17,067 patients) with available data for outcomes were gathered. For 5-yrs DFS/OS, a linear correlation was found between rates (r=0.74, R2=0.55; p<0.0001; Rho=0.83; p<0.0001), and HRs (r=0.90, R2=0.81; p<0.0001; Rho=0.91; p<0.0001). Three-yrs DFS correlates with 5-yrs OS, with both rates (r=0.81, R2=0.66; p<0.0001; Rho=0.92; p<0.0001), and RRs (r=0.84, R2=0.71; p=0.002; Rho=0.85; p=0.002). Three-yrs DFS and 5-yrs OS absolute differences strongly correlate (r=0.86, R2=0.74; p=0.001; Rho=0.84; p=0.002). The sample size model (on the basis of the r-coefficient=0.81), calculates 2,733, 863, and 389 pts to improve 3-yrs DFS of 4%, 7% and 10%, which means to improve 5-yrs OS of 3.2%, 5.7% and 8.1%, respectively. Conclusions: By these data, 3-yrs DFS is a reliable surrogate end-point for OS when testing new drugs in early BC, and is able to predict a late survival benefit. Thanks to the smaller patient sample size, RCTs with this design will provide early results in a shorter time period, allowing a faster data transfer to clinical practice. No significant financial relationships to disclose.
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Turchina, Tatiana A., and Olga A. Bannikova. "Creation of Forest Cultures of Crimean Pine (Pinus pallasiana D. Don) on the Hilly Sands in the Steppe Zone of Russia." Lesnoy Zhurnal (Forestry Journal), no. 3 (August 1, 2023): 76–92. http://dx.doi.org/10.37482/0536-1036-2023-4-76-92.
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Forest crop cultivation of Crimean pine (Pinus pallasiana D. Don) was implemented in 2009–2020 on sandy and sand included soils in the steppe zone of the European part of Russia. During the analysis of the reasons for the low efficiency of reforestation, the authors proposed the hypothesis that the rules of planting recommended for Scots pine relative to the depth of rooting may not be acceptable for Crimean pine. The purpose of the work is to substantiate the necessity and the most optimal value of deepening the root collar of Crimean pine seedlings on hilly sands. Experimental forest cultures were planted in 2017. The depth of the plant collar relative to the soil surface was tested at 0, 2, 4, 6 cm, and until the seedling’s foliated part. The reference group was created by machine cultivation, which required a rooting depth of 6 cm or more. In the case of hand cultivation, the variants with planting depths of 2 and 4 cm had the highest rates of plant survival (94.2–94.6 % in the first year), plant safety (67.0–94.6 % in the fourth year), and their most even distribution over the silvicultural area (variation coefficient (υ) at 6.6–28.8 %). The lack of deepening and very deep planting by 6 cm led to a decrease in plant survival and preservation by 7.6–18.6 % with an increase in the range of the variation coefficient (υ, 10.2–60.6 %). The mechanized planting with a root collar depth over 6 cm gave the lowest number of preserved plants (58.4 % in the first year, 32.7 % in the fourth year), and the greatest range for the variation coefficient (υ, 30.5–70.1 %). An analytical equalization of the density of age dynamics showed that the predicted density would not reach the normative value with low and very deep planting. The established statistically significant differences in the survival rate of forest cultures throughout the observation period (tf = 2.12–4.38> t05 = 2.12–2.45) indicated the expediency of deepening the root collar. The optimal value is 2–4 cm, but until the seedling’s foliated part. For citation: Turchina T.A., Bannikova O.A. Creation of Forest Cultures of Crimean Pine (Pinus pallasiana D. Don) on the Hilly Sands in the Steppe Zone of Russia. Lesnoy Zhurnal = Russian Forestry Journal, 2023, no. 4, pp. 76–92. (In Russ.). https://doi.org/10.37482/0536-1036-2023-4-76-92
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Shlevin, Eli, I. Sam Saguy, Yitzhak Mahrer, and Jaacov Katan. "Modeling the Survival of Two Soilborne Pathogens Under Dry Structural Solarization." Phytopathology® 93, no. 10 (October 2003): 1247–57. http://dx.doi.org/10.1094/phyto.2003.93.10.1247.
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Structural (space) solarization of a closed, empty greenhouse for sanitation involves dry heating to 60°C and higher and low relative humidity (RH), under a fluctuating temperature and RH regime. Survival of inocula of Fusarium oxysporum f. sp. radicis-lycopersici and Sclerotium rolfsii during structural solarization was studied for 4 years (total of 12 experiments) in an attempt to develop a dynamic model for expressing the thermal inactivation of the pathogens. After 20 days of exposure, the populations of F. oxysporum f. sp. radicis-lycopersici and S. rolfsii were reduced by 69 to 95% and by 47.5 to 100%, respectively. The Weibull distribution model was applied to describe pathogen survival. The Weibull rate parameter, b, was found to follow an exponential (for F. oxysporum f. sp. radicis-lycopersici) and the Fermi (for S. rolfsii) functions at constant temperatures. To improve the applicability of the model, fluctuating conditions of both temperature and RH were utilized. The Weibull distribution derivative, expressed as a function of temperature and moisture, was numerically integrated to estimate survival of inocula exposed to structural solarization. Deviations between experimental and calculated values derived from the model were quite small and the coefficient of determination (R 2) values ranged from 0.83 to 0.99 in 9 of 12 experiments, indicating that ambient RH data should be considered. Structural solarization for sanitation could be a viable component in integrated pest management programs.
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Mäntyniemi, Samu, Atso Romakkaniemi, Johan Dannewitz, Stefan Palm, Tapani Pakarinen, Henni Pulkkinen, Anna Gårdmark, and Olle Karlsson. "Both predation and feeding opportunities may explain changes in survival of Baltic salmon post-smolts." ICES Journal of Marine Science 69, no. 9 (May 15, 2012): 1574–79. http://dx.doi.org/10.1093/icesjms/fss088.
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Abstract Mäntyniemi, S., Romakkaniemi, A., Dannewitz, J., Palm, S., Pakarinen, T., Pulkkinen, H., Gårdmark, A., and Karlsson, O. 2012. Both predation and feeding opportunities may explain changes in survival of Baltic salmon post-smolts. – ICES Journal of Marine Science, 69: 1574–1579. The survival of wild and hatchery-reared post-smolts of salmon (Salmo salar) in the Baltic Sea has declined since the 1990s. Direct observations of the processes affecting survival are, however, lacking. Here, the importance of food availability and predation in regulating post-smolt survival is analysed. Based on previous studies, the following explanatory variables were selected: (i) availability of herring (Clupea harengus membras) recruits in the Gulf of Bothnia (Bothnian Sea, Bothnian Bay) in the northern Baltic Sea; (ii) sprat (Sprattus sprattus balticus) and herring abundance in the southern Baltic Sea; and (iii) abundance of grey seal (Halichoerus grypus) along the post-smolt migration route. Bayesian analysis was used to estimate the relative probability of each of the 32 combinations of these variables and revealed that the model including grey seal abundance and herring recruits per post-smolt had the highest posterior probability and a high coefficient of determination. The results suggest that the declining trend in post-smolt survival is explained by the increased number of grey seals, whereas the annual variation in survival coincides with variation in the recruitment of Bothnian Sea herring. However, it remains uncertain whether the observed correlations arise from direct causalities or other mechanisms.
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Рыков, С. А., М. Г. Лысенко, И. В. Шаргородская, Н. С. Лаврик, И. А. Макаренко, Л. П. Новак, and С. В. Выдыборец. "Endothelial Cells Survival in Human Corneal Grafts When Using the Modified Method Treatment of Keratoconus." Офтальмология. Восточная Европа, no. 3 (November 27, 2020): 311–27. http://dx.doi.org/10.34883/pi.2020.10.3.019.
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Проведена лазерная сканирующая конфокальная микроскопия донорских трупных роговиц, предназначенных для кератопластики. С помощью программного обеспечения ImageJ проанализирована рефлективность эндотелия и введено понятие коэффициента рефлективности эндотелиальных клеток роговицы (КРЭКР). В ходе статистической обработки определены морфометрические свойства эндотелиоцитов при конфокальной микроскопии, которые существенно влияют на потерю эндотелиальных клеток на трансплантате и, возможно, являются признаками апоптоза эндотелиоцитов. Разработана методика вископротекции эндотелия кадаверной роговицы на этапе формирования трансплантата. Отмечено, что сочетание качественной отбраковки донорского роговичного материала по разработанным критериям с проведением интраоперационной вископротекции эндотелия сокращает процент потери эндотелиальных клеток на роговичном трансплантате почти в 4 раза в течение первого года после трансплантации, что является профилактикой развития позднего эндотелиального отторжения роговичного трансплантата. Установлено, что общий (абсолютный и относительный) брак донорских роговиц для проведения сквозной аллокератопластики при кератоконусе составляет приблизительно 60%. Keratoconus is a disorder of the eye characterized by thinning and protrusion of the cornea, resulting in an irregular, conical shape and is the cause of persistent decline in vision and disability of young able-bodied people. Despite development of lamellar techniques of corneal surgery, penetrating keratoplasty remains the "gold standard" in the keratoconus treatment. The rapid loss of endothelial cells on the corneal graft at 6 months after keratoplasty is an important early symptom of late graft rejection (Lass J.H. et all, 2010). The aim of this study is to improve the quality of preservation ofendothelial cells on the native corneal grafts. This task can be solved by qualitative preliminary selection of donor tissue and reduction of intraoperative traumatization of endothelium on corneal graft.Methods. In Kyiv ophthalmic city hospital "Eye microsurgery center" (Kyiv, Ukraine) determined preoperative endothelium cells density by Heidelberg Retina Tomograph HRT II Rostock Cornea Module and were archived available endothelium cells images (590 human cadaveric corneas). Endothelial cells reflectivity analyses performed by ImageJ free software. Proposed to introduce the concept of the coefficient of reflectivity of corneal endothelial cells. Also noted the presence of organelles and "swelling" endothelial cells.In 1st clinic group (n=57) all the patients got standard penetrating keratoplasty procedure with standardly graft exams. Investigated the dependence of rapid endothelial cells loss with endothelial morphometric properties. In 2nd clinic group (n=29) all the patients got standard penetrating keratoplasty procedure with qualitative screening of corneas with new morphometric criteria (coefficient of corneal endothelial reflectivity more, than 50; without "swelling" endothelial cells and without organelles in the endothelial cells). In 3rd clinic group (n=43) patients got qualitative screening of corneas (like 2nd group), but viscoprotection during "back table" procedure has been developed.Results. As a result, combination of qualitative rejection of cadaveric corneas with morphometric endothelial factors reduces the percentage of cell loss four times. Tree morphometric factors in any combination were related with rapid loss of endothelial cells in graft: coefficient of corneal endothelial reflectivity lower, than 50; "swelling" endothelial cells and organelles in the endothelial cells. Determined that total (absolute and relative) qualitative rejection make unsuitable for penetrating keratoplasty for keratoconus approximately 60% of cadaveric corneas.Discussion. This study may help to reduce endothelial cells loss and frequency of late endothelial rejection of corneal grafts. Tree morphometric factors in any combination were related with rapid loss of endothelial cells in graft: coefficient of corneal endothelial reflectivity lower, than 50; "swelling" endothelial cells and organelles in the endothelial cells. Perhaps, these factors are markers of endothelial cells apoptosis.Conclusion. Investigated the dependence of rapid endothelial cells loss with endothelial morphometric properties. Proposed to introduce the concept of the coefficient of reflectivity of corneal endothelial cells. Proposed the methodology of endothelial viscoprotection during "back table" procedure before penetrating keratoplasty.
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Milella, M., E. Bria, P. Carlini, F. Cuppone, A. Gelibter, C. Nisticò, E. M. Ruggeri, E. Terzoli, F. Cognetti, and D. Giannarelli. "Surrogate endpoints for overall survival (OS) in advanced pancreatic cancer (APC): Analysis of randomized clinical trials (RCTs) exploring gemcitabine (G)-based combinations." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 4575. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4575.
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4575 Background: G-based combinations often result in an improved overall response rate (ORR) in APC; this improvement in ORR, however, seldom translates into a significant OS advantage. We therefore evaluated the appropriateness of ORR and progression-free survival (PFS) as surrogate endpoints for OS in RCTs comparing single-agent G and G-based combinations as first-line treatment for APC. Methods: Phase III trials reporting ORR or PFS and OS data were considered eligible. Potential correlations were explored according to a linear regression model considering both the actual outcome (ORR or PFS and OS) for each single arm and the calculated relative risk (RR) for each outcome in paired comparisons. Correlation was estimated according to Pearson’s (r) and R2 coefficients (parametric) and Spearman’s (Rho) coefficient (non-parametric). A model to calculate the target sample size to correctly identify 0.4, 0.7, and 1.5 mos benefits in OS was derived as well. Results: Nineteen (6,288 pts) and 17 (4,882 pts) RCTs were identified for the ORR/OS and PFS/OS correlation, respectively. When considering ORR rates and medians, ORR did not significantly correlate with OS (r=0.23, R2=0.06, p=0.14; Rho=0.16, p=0.33), while PFS showed a strong linear correlation (r=0.75, R2=0.56, p<0.0001; Rho=0.90, p<0.0001). Similarly, when considering RRs, ORR did not significantly correlate with OS (r=-0.17, R2=0.03, p=0.46; Rho=-0.18, p=0.44), while PFS showed a strong linear correlation (r=0.91, R2=0.82, p<0.0001; Rho=0.59, p=0.01). Based on these data, we derived a sample size model (beta-coefficient=0.75) to calculate how many patients would be necessary to demonstrate a significant OS advantage of 0.4, 0.7 and 1.5 mos, respectively, using PFS as a surrogate endpoint; according to this model, 0.5, 1, and 2 months improvements in PFS would be necessary to translate into the target OS advantages, requiring 2,370, 678 and 222 pts, respectively. Conclusions: In APC, ORR does not seem to correlate with OS. Conversely, PFS could be a reliable surrogate endpoint for survival in this setting, although the detection of relatively small differences in PFS would require a remarkably large sample size. No significant financial relationships to disclose.
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Imai, Hisao, Takayuki Kishikawa, Hiroyuki Minemura, Yutaka Yamada, Tatsuya Ibe, Keita Mori, Ou Yamaguchi, et al. "Post-Progression Survival Influences Overall Survival among Patients with Advanced Non-Small Cell Lung Cancer Undergoing First-Line Pembrolizumab Monotherapy." Oncology 99, no. 9 (2021): 562–70. http://dx.doi.org/10.1159/000516745.
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<b><i>Background:</i></b> Among patients with non-small cell lung cancer (NSCLC), the impact of first-line treatment on overall survival (OS) may be influenced by subsequent therapies. Thus, using patient-level data, we assessed the relationships of progression-free survival (PFS) and post-progression survival (PPS) with OS among patients with high-programmed death-ligand 1 (PD-L1) expression undergoing first-line pembrolizumab monotherapy for NSCLC. <b><i>Methods:</i></b> We reviewed data from 133 patients with high PD-L1 expression undergoing first-line pembrolizumab monotherapy for NSCLC at 6 Japanese centers between February 2017 and December 2018. The correlations of PFS and PPS with OS were evaluated at the patient level. <b><i>Results:</i></b> Linear regression analyses and Spearman’s rank correlation coefficient revealed that PPS was strongly correlated with OS (<i>r</i> = 0.76, <i>p</i> < 0.05, <i>R</i><sup>2</sup> = 0.65), while PFS was only moderately correlated with OS (<i>r</i> = 0.71, <i>p</i> < 0.05, and <i>R</i><sup>2</sup> = 0.4). Furthermore, PPS was significantly associated with performance status at the end of pembrolizumab monotherapy, as well as the use of platinum-based combination chemotherapy after pembrolizumab monotherapy (both <i>p</i> < 0.05). <b><i>Conclusions:</i></b> Among patients with high PD-L1 expression undergoing first-line pembrolizumab monotherapy for NSCLC, PPS was more strongly correlated with OS, relative to the relationship between PFS and OS. Therefore, subsequent treatment appears to significantly influence OS in patients with disease progression following first-line pembrolizumab monotherapy.
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Hagiwara, Akifumi, Yao Jingwen, Talia Oughourlian, Chencai Wang, Catalina Raymond, Richard Everson, Kunal Patel, et al. "NIMG-45. DIFFUSION MRI AS AN EARLY BIOMARKER OF OVERALL SURVIVAL BENEFIT IN RECURRENT GLIOBLASTOMA TREATED WITH IMMUNE CHECKPOINT INHIBITORS." Neuro-Oncology 23, Supplement_6 (November 2, 2021): vi139. http://dx.doi.org/10.1093/neuonc/noab196.544.
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Abstract Diffusion magnetic resonance imaging (MRI) estimates of the apparent diffusion coefficient (ADC) has been revealed to be useful for predicting treatment response in patients with glioblastoma (GBM), with an increase in ADC indicating tumor cell death. The aim of the current study was to investigate whether quantitative changes in diffusion MRI after treatment with immune checkpoint inhibitors (ICI) could predict OS in patients with recurrent GBM. A total of 61 patients were included in this retrospective study with the following inclusion criteria: (i) diagnosis of recurrent GBM treated either with pembrolizumab or nivolumab and (ii) availability of diffusion data in pre- and post-ICI MRI. Tumor volume and median relative apparent diffusion coefficient (rADC) within enhancing tumor with respect to normal-appearing white matter were calculated. Median OS for all patients was 7.6 months (range, 1.0–30.6 months). Results showed that higher post-treatment rADC was associated with significantly longer OS (median, 372 days for rADC ≧ 1.42 versus 211 days for rADC < 1.42; P = 0.01, log-rank test), whereas tumor volume and pre-treatment rADC were not significantly associated with OS. Cox regression analysis revealed post-treatment rADC significantly influences OS (P = 0.02, univariate analysis), even after controlling for age, sex, and IDH status (P = 0.007, multivariate analysis), and additionally controlling for whether surgery was performed after ICI treatment (P = 0.049, multivariate analysis). In conclusion, a high post-treatment rADC may be an early imaging biomarker for identifying OS benefit in recurrent GBM patients receiving ICI treatment.
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van Dijken, Bart Roelf Jan, Peter Jan van Laar, Chao Li, Jiun-Lin Yan, Natalie Rosella Boonzaier, Stephen John Price, and Anouk van der Hoorn. "Ventricle contact is associated with lower survival and increased peritumoral perfusion in glioblastoma." Journal of Neurosurgery 131, no. 3 (September 2019): 717–23. http://dx.doi.org/10.3171/2018.5.jns18340.
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OBJECTIVEThe purpose of this study was to prospectively investigate outcome and differences in peritumoral MRI characteristics of glioblastomas (GBMs) that were in contact with the ventricles (ventricle-contacting tumors) and those that were not (noncontacting tumors). GBMs are heterogeneous tumors with variable survival. Lower survival is suggested for patients with ventricle-contacting tumors than for those with noncontacting tumors. This might be supported by aggressive peritumoral MRI features. However, differences in MRI characteristics of the peritumoral environment between ventricle-contacting and noncontacting GBMs have not yet been investigated.METHODSPatients with newly diagnosed GBM underwent preoperative MRI with contrast-enhanced T1-weighted, FLAIR, diffusion-weighted, and perfusion-weighted sequences. Tumors were categorized into ventricle-contacting or noncontacting based on contrast enhancement. Survival analysis was performed using log-rank for univariate analysis and Cox regression for multivariate analysis. Normalized perfusion (relative cerebral blood volume [rCBV]) and diffusion (apparent diffusion coefficient [ADC]) values were calculated in 2 regions: the peritumoral nonenhancing FLAIR region overlapping the subventricular zone and the remaining peritumoral nonenhancing FLAIR region.RESULTSOverall survival was significantly lower for patients with contacting tumors than for those with noncontacting tumors (434 vs 747 days, p < 0.001). Progression-free survival showed a comparable trend (260 vs 375 days, p = 0.094). Multivariate analysis confirmed a survival difference for both overall survival (HR 3.930, 95% CI 1.740–8.875, p = 0.001) and progression-free survival (HR 2.506, 95% CI 1.254–5.007, p = 0.009). Peritumoral perfusion was higher in contacting than in noncontacting tumors for both FLAIR regions (p = 0.04). There was no difference in peritumoral ADC values between the 2 groups.CONCLUSIONSPatients with ventricle-contacting tumors had poorer outcomes than patients with noncontacting tumors. This disadvantage of ventricle contact might be explained by higher peritumoral perfusion leading to more aggressive behavior.
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Sita, Timothy, Lisa Hurley, Michael Drumm, Serena Tommasini-Ghelfi, Akanksha Mahajan, Corey Dussold, Kevin Murnan, et al. "EXTH-36. ELECTROCONVULSIVE SEIZURE-INDUCED CHANGES IN THE TUMOR MICROENVIRONMENT PROMOTE SURVIVAL IN GLIOMA-BEARING MICE." Neuro-Oncology 23, Supplement_6 (November 2, 2021): vi171. http://dx.doi.org/10.1093/neuonc/noab196.675.
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Abstract PURPOSE Growing evidence indicates that the neurotransmitters dysregulated in psychiatric disorders are similarly dysregulated in glioblastoma (GBM) biology. GBM cells are dependent on bountiful neuronal glutamate, utilize elevated dopamine receptor expression to augment progression, and catabolize serotonin to drive proliferation and inhibit anti-tumor immunity. The clinical induction of seizure, known as electroconvulsive therapy (ECT), has been used by psychiatrists since the 1930s to correct these dysregulations and can additionally improve medication blood-brain barrier (BBB) penetrance. We hypothesized that seizure-induced changes in the glioma microenvironment occur with ECT, slowing tumor progression, increasing BBB permeability, and prolonging overall survival in glioma-bearing mice. METHODS C57BL6 mice were orthotopically injected with CT-2A-Luc mouse glioma cells. Mice were randomized to receive ECT via ear-clip electrodes or sham treatment daily up to five times per week. Intracranial progression was monitored via bioluminescent signal from CT-2A-Luc xenografts. BBB permeability was assessed by subjecting mice to ECT or sham treatment immediately following intravenous injection of sodium fluorescein. RESULTS Intracranial progression was maximally reduced in ECT-treated mice relative to sham-treated mice after 17 ECT treatments (ECT radiance 2.6 x 109 photons/second versus sham 4.7 x 109 photons/second, p=0.013), which was further confirmed by both decreased tumor weight and tumor size on histologic evaluation. This translated into an improvement in overall survival from median 29 days in sham-treated mice to 38 days in ECT-treated mice (p=0.0018). Mean seizure duration was 41.8 seconds and positively correlated with overall survival (Pearson coefficient r=0.63, p=0.028). Brain parenchymal uptake of sodium fluorescein was significantly higher in ECT-treated mice (mean relative increase in ECS to sham radiance of 1.47, p< 0.05). CONCLUSION Repeated ECT slows tumor progression and prolongs overall survival in C57BL6 mice bearing CT-2A-Luc xenografts. The BBB is compromised immediately following ECT. ECT merits further oncologic investigation as a potential therapeutic in GBM.
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Juneja, Vijay K., Harry M. Marks, and Tim Mohr. "Predictive Thermal Inactivation Model for Effects of Temperature, Sodium Lactate, NaCl, and Sodium Pyrophosphate on Salmonella Serotypes in Ground Beef." Applied and Environmental Microbiology 69, no. 9 (September 2003): 5138–56. http://dx.doi.org/10.1128/aem.69.9.5138-5156.2003.
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ABSTRACT Analyses of survival data of a mixture of Salmonella spp. at fixed temperatures between 55°C (131°F) and 71.1°C (160°F) in ground beef matrices containing concentrations of salt between 0 and 4.5%, concentrations of sodium pyrophosphate (SPP) between 0 and 0.5%, and concentrations of sodium lactate (NaL) between 0 and 4.5% indicated that heat resistance of Salmonella increases with increasing levels of SPP and salt, except that, for salt, for larger lethalities close to 6.5, the effect of salt was evident only at low temperatures (<64°C). NaL did not seem to affect the heat resistance of Salmonella as much as the effects induced by the other variables studied. An omnibus model for predicting the lethality for given times and temperatures for ground beef matrices within the range studied was developed that reflects the convex survival curves that were observed. However, the standard errors of the predicted lethalities from this models are large, so consequently, a model, specific for predicting the times needed to obtained a lethality of 6.5 log10, was developed, using estimated results of times derived from the individual survival curves. For the latter model, the coefficient of variation (CV) of predicted times range from about 6 to 25%. For example, at 60°C, when increasing the concentration of salt from 0 to 4.5%, and assuming that the concentration of SPP is 0%, the time to reach a 6.5-log10 relative reduction is predicted to increase from 20 min (CV = 11%) to 48 min (CV = 15%), a 2.4 factor (CV = 19%). At 71.1°C (160°F) the model predicts that more than 0.5 min is needed to achieve a 6.5-log10 relative reduction.
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Huang, Han Chen. "Using a Multilayer Perceptrons Neural Network and Genetic Algorithm to Predict the NTD/USD Exchange Rate." Advanced Materials Research 542-543 (June 2012): 1347–52. http://dx.doi.org/10.4028/www.scientific.net/amr.542-543.1347.
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In recent years, the global community has experienced economic difficulties, such as the 2008 financial crisis and the ongoing European debt crisis. Consequently, currency values have fluctuated significantly over short periods of time, which increases the difficulty of survival and fear of businesses that rely on import and export trade. Failure to properly and appropriately address the operational risks of exchange rate fluctuations can reduce corporate profit and even lead to operational losses. However, financial markets provide numerous methods for corporations to hedge the risks of exchange rate fluctuations. Nevertheless, a model for predicting exchange rate fluctuations can enable business owners to make more appropriate judgments. This study employs a multilayer perceptions (MLP) neural network with genetic algorithm (GA) to predict the New Taiwan dollar (NTD)/U.S. dollar (USD) exchange rate. The GA is used to determine the optimum number of input and hidden nodes for a feedforward neural network, the optimum slope of the activation function, and the optimum learning rates and momentum coefficients. The empirical results show that the ability of the proposed model to predict the NTD/USD exchange rate is excellent. The absolute relative error between the predicted value and the actual value was 0.2948%, and the correlation coefficient was 0.994802.
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Anand, Seerat, Daniel Tannenbaum, Robert Asa Horn, Van K. Morris, Benny Johnson, Cathy Eng, Scott Kopetz, Michael J. Overman, Kanwal Pratap Singh Raghav, and Arvind Dasari. "A systematic review of surrogate endpoints (SEPs) for overall survival (OS) in metastatic colorectal cancer (mCRC)." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e18206-e18206. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e18206.
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e18206 Background: Although progression free survival (PFS) and overall response rate (ORR) are common endpoints in mCRC trials, validation of these as SEPs for OS across the evolving landscape of systemic treatment in mCRC, with novel therapeutics and expanding lines of treatment, is limited. We aimed to evaluate the potential surrogacy of PFS and RR for OS and explore variations across trial factors. Methods: We identified phase 3 randomized trials of systemic therapy in mCRC between 1986 - 2016 from 4 electronic databases. Data regarding endpoints and trial variables were extracted from published reports. Spearman’s coefficient (r) and linear regression were used to evaluate rank correlations between A) PFS and ORR with OS of both treatment and control arms (arm level analysis); B) net improvement in outcomes using hazard ratio (HR) for PFS and relative risk (RR) for ORR with HR for OS (trial level analysis). Results: A total of 128 trials containing 233 and 230 arms reporting on PFS and ORR, respectively, were identified. Arm level analysis revealed that correlation of PFS and ORR with OS was 0.69 (95%CI: 0.6 – 0.7) and 0.79 (95%CI: 0.7 – 0.8), respectively ( P < 0.001). Of 86 trials with reported HR for OS, PFS and ORR ratios were obtained for 84 and 74 trials, respectively. Trial level analysis revealed that correlation of PFS and ORR treatment effect with OS was 0.71 (95%CI: 0.6 – 0.8) and 0.58 (95%CI: 0.4 – 0.7), respectively ( P < 0.001). Level of correlation for PFS and ORR varied with line of therapy, type of therapy and trial size (Spearman r shown in table). Conclusions: Both ORR and PFS are appropriate SEPs for OS for systemic therapy in mCRC but their relative value varies notably with line/type of therapy and study size. Judicious use of these SEPs in clinical trials accordingly to supplant OS may help improve trial designs and performance.[Table: see text]
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Raskolupova, Valeria I., Meiling Wang, Maya A. Dymova, Gleb O. Petrov, Ivan M. Shchudlo, Sergey Yu Taskaev, Tatyana V. Abramova, Tatyana S. Godovikova, Vladimir N. Silnikov, and Tatyana V. Popova. "Design of the New Closo-Dodecarborate-Containing Gemcitabine Analogue for the Albumin-Based Theranostics Composition." Molecules 28, no. 6 (March 15, 2023): 2672. http://dx.doi.org/10.3390/molecules28062672.
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Combination therapy is becoming an increasingly important treatment strategy because multi-drugs can maximize therapeutic effect and overcome potential mechanisms of drug resistance. A new albumin-based theranostic containing gemcitabine closo-dodecaborate analogue has been developed for combining boron neutron capture therapy (BNCT) and chemotheraphy. An exo-heterocyclic amino group of gemcitabine was used to introduce closo-dodecaborate, and a 5′-hydroxy group was used to tether maleimide moiety through an acid-labile phosphamide linker. The N-trifluoroacylated homocysteine thiolactone was used to attach the gemcitabine analogue to human serum albumin (HSA) bearing Cy5 or Cy7 fluorescent dyes. The half-maximal inhibitory concentration (IC50) of the designed theranostic relative to T98G cells was 0.47 mM with the correlation coefficient R = 0.82. BNCT experiments resulted in a decrease in the viability of T98G cells, and the survival fraction was ≈ 0.4.
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McDaniel, Justin T., Kaamel Nuhu, Juan Ruiz, and Genevieve Alorbi. "Social determinants of cancer incidence and mortality around the world: an ecological study." Global Health Promotion 26, no. 1 (March 16, 2017): 41–49. http://dx.doi.org/10.1177/1757975916686913.
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Cancer continues to be a leading cause of mortality and morbidity the world over. While the incidence of cancer is projected to increase by 70% over the next two decades, some research findings suggest a disproportionate distribution of new cancer cases and attendant fatalities across certain regions of the world, with poor and lower income countries worse affected at a time when advances in cancer research, medical technology, and drug development are giving rise to better cancer survival in developed countries. In this study, the role of selected social determinants of health in gauging cancer outcomes relative to incidence across various countries in different regions of the world was explored. The results indicated that the education index, income index, Gini coefficient, availability of cancer control policies and programs, as well as health system performance have an association with and are good predictors of the mortality to incidence ratio (MIR) of lung, breast, cervical, and colorectal cancers. In other words, populations with better education, higher incomes and lower inequalities, active cancer control policies and programs and high performing health systems have better cancer outcomes as reflected in lower MIRs relative to other populations.
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Li, Chao, Shuo Wang, Jiun-Lin Yan, Turid Torheim, Natalie R. Boonzaier, Rohitashwa Sinha, Tomasz Matys, Florian Markowetz, and Stephen J. Price. "Characterizing tumor invasiveness of glioblastoma using multiparametric magnetic resonance imaging." Journal of Neurosurgery 132, no. 5 (May 2020): 1465–72. http://dx.doi.org/10.3171/2018.12.jns182926.
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OBJECTIVEThe objective of this study was to characterize the abnormalities revealed by diffusion tensor imaging (DTI) using MR spectroscopy (MRS) and perfusion imaging, and to evaluate the prognostic value of a proposed quantitative measure of tumor invasiveness by combining contrast-enhancing (CE) and DTI abnormalities in patients with glioblastoma.METHODSEighty-four patients with glioblastoma were recruited preoperatively. DTI was decomposed into isotropic (p) and anisotropic (q) components. The relative cerebral blood volume (rCBV) was calculated from the dynamic susceptibility contrast imaging. Values of N-acetylaspartate, myoinositol, choline (Cho), lactate (Lac), and glutamate + glutamine (Glx) were measured from multivoxel MRS and normalized as ratios to creatine (Cr). Tumor regions of interest (ROIs) were manually segmented from the CE T1-weighted (CE-ROI) and DTI-q (q-ROI) maps. Perfusion and metabolic characteristics of these ROIs were measured and compared. The relative invasiveness coefficient (RIC) was calculated as a ratio of the characteristic radii of CE-ROI and q-ROI. The prognostic significance of RIC was tested using Kaplan-Meier and multivariate Cox regression analyses.RESULTSThe Cho/Cr, Lac/Cr, and Glx/Cr in q-ROI were significantly higher than CE-ROI (p = 0.004, p = 0.005, and p = 0.007, respectively). CE-ROI had significantly higher rCBV values than q-ROI (p < 0.001). A higher RIC was associated with worse survival in a multivariate overall survival (OS) model (hazard ratio [HR] 1.40, 95% confidence interval [CI] 1.06–1.85, p = 0.016) and progression-free survival (PFS) model (HR 1.55, 95% CI 1.16–2.07, p = 0.003). An RIC cutoff value of 0.89 significantly predicted shorter OS (median 384 vs 605 days, p = 0.002) and PFS (median 244 vs 406 days, p = 0.001).CONCLUSIONSDTI-q abnormalities displayed higher tumor load and hypoxic signatures compared with CE abnormalities, whereas CE regions potentially represented the tumor proliferation edge. Integrating the extents of invasion visualized by DTI-q and CE images into clinical practice may lead to improved treatment efficacy.
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Chao, Xu, Wei Zhang, Jieqiong Wu, Xuesong Feng, Hailong Shi, Luyan Zhao, Haiyu Shen, and Chao Jiang. "Downregulation of LHPP Expression Associated with AFP Acts as a Good Prognostic Factor in Human Hepatocellular Carcinoma." BioMed Research International 2021 (August 25, 2021): 1–9. http://dx.doi.org/10.1155/2021/1971048.
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Background. Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) serves as a tumor suppressor in hepatocellular carcinoma (HCC), but the correlation between the expression of LHPP and the clinical parameters of oncogenic progression is still not well defined. This study is to reveal the correlation between the expression of LHPP in HCC and their clinical parameters. Methods. Immunohistochemical analysis was used to assess the correlation between the expression of LHPP and the clinical parameters of HCC. Expressions of LHPP in HCC tissues and cultured HCC cells were detected by Western blot and quantitative real-time polymerase chain reaction (qRT-PCR). LHPP, gamma-glutamyl transferase (GGT), and α-fetoprotein (AFP) expression levels in blood or HCC tissues were detected by enzyme-linked immunosorbent assay (ELISA). The Spearman rank correlation coefficient was used to evaluate the correlation of the expression of LHPP and the clinical index of HCC. Correlation of survival and expression of LHPP were analyzed using the Kaplan-Meier method and the log-rank test. Results. Expressions of LHPP in HCC tissues were significantly downregulated than their paired adjacent normal tissues. A significant positive correlation was found between the cytoplasm and nuclear expression of LHPP in both HCC and their paired adjacent normal tissues. The expression of LHPP negatively correlated with the levels of GGT in the cytoplasm of adjacent tissues and with the AFP level in the nucleus of HCC cells. Relative levels of LHPP in HCC tissues were markedly lower than those of the paired adjacent normal tissues. Relative levels of LHPP in LO-2 cells were higher than those of HepG2, BEL-7404, and SMMC-7721 cell lines. The overall survival and DSF survival of patients with the high expression of LHPP were much higher than those with the low expression of LHPP in paired adjacent normal tissue. Conclusions. LHPP is associated with the AFP level and acts as a good prognostic factor in HCC.
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Ginwal, H. S., Pradip Kumar, V. K. Sharma, and A. K. Mandal. "Seed Source Variation in Growth Performance of Eucalyptus camaldulensis Dehnh. of Australian Origin in India." Silvae Genetica 53, no. 1-6 (December 1, 2004): 182–86. http://dx.doi.org/10.1515/sg-2004-0033.
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Abstract Results of a provenance trial of Eucalyptus camaldulensis Dehnh. laid out in 2001 at Seothi (30° N Lat., 76° E Long. and 250 m altitude) Haryana, a semi-arid region of India are reported and discussed. Six seed sources from Australia viz. Laura River, Emu Creek, Degrey River, Wiluna, Kennedy River, Morehead River were evaluated from nursery stage (3 months) to field performance (2 year). Two sources viz. E.tereticornis (Helenvele, Qld) and FRI-4 a local seed source were used as control (check material). Significant differences between the seed sources at nursery stage were observed for collar diameter (P < 0.05) and number of leaves (P < 0.01). At age 2 years, significant differences between the seed sources (P < 0.05) were observed for height and field survival. The two seed sources viz. Emu Creek Petford, QLD and Laura river, QLD ranked first and second for height and survival at this age. Results indicate that genetic differences exist between the sources of E. camaldulensis. None of the traits assessed (viz. height, collar diameter, number of leaves, number of branches and survival) was found to correlate with any of the geographical coordinates of the site (latitude, longitude and altitude). There were fair differences between phenotypic and genotypic coefficient of variability. Heritability values were fairly high for height and clear bole length in comparison to collar diameter, number of branches and survival. The relative performance of these provenances was fairly consistent throughout the period of observation. The two sources viz. Laura river, QLD and Emu Creek Petford, QLD are recommended for potential source for plantation programme under semi-arid conditions.
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Ginwal, H. S., and A. K. Mandal. "Variation in Growth Performance of Acacia nilotica Willd. ex Del. Provenances of Wide Geographical Origin : Six Year Results." Silvae Genetica 53, no. 1-6 (December 1, 2004): 264–69. http://dx.doi.org/10.1515/sg-2004-0049.
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Abstract Results of a provenance trial of Acacia nilotica Willd. ex Del. laid out in 1993 at Tropical Forest Research Institute Campus, Jabalpur (23°N lat., 79°E long. and 400 m altitude) Madhya Pradesh, a semi-arid region of India are reported and discussed. Nineteen provenances from India, Pakistan, Sudan, Senegal and Yemen were evaluated in the field at age three and six years. Local source of A. nilotica (S.F.R.I., Jabalpur) was used as check material for comparison. Significant differences between the provenances (P < 0.05) were observed for height, diameter at breast height (DBH), number of branches and field survival. The provenances from Gujrat (Punjab), Pakistan, ranked first for growth traits namely height, DBH and survival. The next superior provenance was from Beihan, Yemen, which scored second highest values of height and DBH and had good survival at age six years. Results indicate that genetic differences exist between the provenances of A.nilotica. None of the traits assessed (viz. height, DBH, number of branches, inter-nodal length and survival) were found to correlate with any of the geographical coordinates of the provenances (latitude, longitude and altitude). Height, DBH and number of branches showed significant and positive correlation with each other. Fair differences between phenotypic and genotypic coefficient of variability were observed. Heritability values were found fairly good for height, DBH and number of branches as compared to inter-nodal length. The relative performance of these provenances was fairly consistent throughout the period of observation at three and six year. The two sources viz. Gujrat (Punjab), Pakistan and Beihan, Yemen, are recommended for plantation programme under semi-arid conditions.
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Vaneeva, E. V., V. A. Rosin, D. A. Dyakonov, and S. V. Samarina. "Association of expression of pSTAT3, pAKT1 with the survival of patients with diffuse large B-cell lymphoma." Kazan medical journal 101, no. 4 (August 12, 2020): 501–6. http://dx.doi.org/10.17816/kmj2020-501.
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Aim. To assess the relationship between isolated and combined expression of pSTAT3, pACT1 in tumor cells with the survival of patients with diffuse large B-cell lymphoma (DLBCL).
Methods. The study included 100 patients with the first diagnosed diffuse large B-cell lymphoma, observed in the institute's clinic between 2010 and 2018 who received standard first-line R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy. The relative number of expressing pSTAT3 and pAKT1 tumor cells was determined by using immunohistochemical and morphometric methods. The optimal cut-off level of expression on tumor cells estimated by using receiver operating characteristic (ROC) curve analysis for pSTAT3 was 68% and for pACT1 70%. Given these values, all patients with DLBCL were divided into groups with a high and low degree of expression of the biomarkers. As a result, 53 patients were enrolled in the pSTAT3 high expression group (68% tumor cells) and 47 patients to the pSTAT3 low expression group (68% tumor cells). Spearmans correlation coefficient was used to examine relationships. Overall survival and event-free survival were estimated by KaplanMeier curves. The log-rank test was used for groups comparison.
Results. The five-year overall survival rate in the pSTAT3 high expression group was 55% versus 87% in the low expression group, p=0.015. A significant difference was found in the assessment of event-free survival: 43% for the group of pSTAT3 high expression, 66% for the group of low expression, p=0.011. A statistically significant value of a high level of pACT1 expression was revealed for 5-year overall and event-free survival (p 0.001 and p=0.003). Overall survival rate was 81% for the pACT1 low expression group and 43% for the high expression group while event-free survival rate was 64 and 41%, respectively. Also, patients with рАКТ1+/рSTAT3+ (high level) co-expression had extremely low rates of overall and event-free survival rates compared with the рАКТ1/рSTAT3 (low level) group (p=0.001; p 0.001).
Conclusion. The pSTAT3 and pAKT1 biomarkers can be used as additional prognosis criteria for diffuse large B-cell lymphoma.
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Liu, Yasong, and Wentao Xu. "Adoption of Diffusion Tensor Imaging under Optimized Fuzzy C-Means Cluster Algorithm in Intracerebral Benign and Malignant Tumor Resection." Scientific Programming 2021 (August 2, 2021): 1–7. http://dx.doi.org/10.1155/2021/3215087.
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The study aimed to analyze the application of diffusion tensor imaging (DTI) in the surgery of benign and malignant intracranial tumors through improved fuzzy C-means (FCM). First, a method of combining the maximum and minimum distances was proposed to improve the FCM algorithm. Then, the optimized FCM was applied to the diffusion tensor imaging (DTI) diagnosis. The patients were rolled into the benign tumor group and the malignant tumor group, and relevant parameters were compared. Finally, the postoperative total resection rate and disability rate of the DTI experimental group and the traditional control (Ctrl) group were evaluated. It was found that the segmentation accuracy of the optimized FCM algorithm was higher than traditional one and the obtained corpus callosum edge contour was clearer. In 63 patients with intracranial space, there were obvious differences in pairwise comparison of meningioma and glioma, metastatic tumor’s apparent diffusion coefficient (ADC) value, relative apparent diffusion coefficient (r ADC) value, and relative anisotropy fraction (r FA) P < 0.05 . In terms of the ADC, r ADC, and r FA values of tumor parenchymal area, those of benign tumors were larger than malignant tumors P < 0.05 . The ADC value (8.21 ± 1.87) and r FA value (1.36 ± 0.41) of the contralateral normal white matter area of malignant tumor were greater than the ADC value (7.23 ± 2.31) and r FA value (0.61 ± 0.24) of the peritumor white matter area, with statistically significant differences P < 0.05 . The total cut rates of the experimental group and the Ctrl were 87.5% and 54.84%, and the disability rates were 6.25% and 34.38%. In conclusion, the optimized FCM has high accuracy. The ADC, r ADC, and r FA values of DTI are important in the diagnosis of intracranial tumors. Besides, DTI can improve the survival rate in guiding intracranial tumor resection.
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Jin, Yuan-Ting, and Nai-Fa Liu. "Altitudinal variation in reproductive strategy of the toad-headed lizard, Phrynocephalus vlangalii in North Tibet Plateau (Qinghai)." Amphibia-Reptilia 28, no. 4 (2007): 509–15. http://dx.doi.org/10.1163/156853807782152507.
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Abstract Phrynocephalus vlangalii, a toad-headed viviparous sand lizard, is endemic in the Northern Tibet (Qinghai) Plateau in China. Lizards were collected from 14 localities along the large altitudinal gradient (2289-4565 m a.s.l) to analyze the variation of reproductive traits among localities. Both litter size and mean offspring (scaled embryo) mass were positively correlated with female snout-vent length (SVL). Females produced fewer and larger offspring with increasing elevation when the effect of body size (SVL) was removed. This strategy may possibly be correlated with early survival and growth of offspring. The decreased litter size cline along altitudinal gradient might be correlated with more anatomical constraints at higher altitudes. The lizard has lower coefficient of variation (CV) of litter size at higher environments. Moreover, females from higher elevations had less reproductive investment (relative litter mass, RLM). Study concluded that P. vlangalii fit into the common pattern of higher elevation animals that have smaller clutches of larger offspring and lower reproductive effort.
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Eliwa, Mohamed S., Rashad M. EL-Sagheer, Samah H. El-Essawy, Bader Almohaimeed, Fahad S. Alshammari, and Mahmoud El-Morshedy. "General Entropy with Bayes Techniques under Lindley and MCMC for Estimating the New Weibull–Pareto Parameters: Theory and Application." Symmetry 14, no. 11 (November 12, 2022): 2395. http://dx.doi.org/10.3390/sym14112395.
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Censored data play a pivotal role in life testing experiments since they significantly reduce cost and testing time. Hence, this paper investigates the problem of statistical inference for a system of progressive first-failure censoring data for a new Weibull–Pareto distribution. Maximum likelihood estimates for the parameters as well as some lifetime indices such as reliability, hazard rate functions, and coefficient of variation are derived. Lindley approximation and the Markov chain Monte Carlo technique are applied to obtain the Bayes estimates relative to two different loss functions: balanced linear exponential and general entropy loss functions. The results of the Bayes estimate are computed under the consideration of informative prior function. A real-life example "the survival times in years of a group of patients given chemotherapy treatment" is presented to illustrate the proposed methods. Finally, a simulation study is carried out to determine the performance of the maximum likelihood and Bayes estimates and compare the performance of different corresponding confidence intervals.
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Wang, Zhiqi, Xiaobo Feng, Zhihong Yao, Zhaolong Ma, and Guodong Ji. "Spatial-Temporal Simulations of Soil Moisture Content in a Large Basin of the Loess Plateau, China." Journal of Sensors 2021 (April 13, 2021): 1–11. http://dx.doi.org/10.1155/2021/6638728.
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Soil moisture is a crucial factor limiting the growth and survival of plants on the Loess Plateau. Its level has a severe impact on plants’ growth and development and the type and distribution characteristics of communities. This study area is the Jihe Basin in the Loess Plateau, China. Multiple linear regression models with different environmental variables (land use, topographic and meteorological factors, etc.) were developed to simulate soil moisture’s spatial and temporal changes by integrating field experiments, indoor analysis, and GIS spatial analysis. The model performances were evaluated in the Jihe Basin, with soil moisture content measurements. The result shows that soil moisture content is positively correlated with soil bulk density, monthly rainfall, topographic wetness index, land use coefficient, and slope aspect coefficient but negatively correlated with the monthly-averaged temperature and the relative elevation coefficient. The selected variables are all related to the soil moisture content and can account for 75% of the variations of soil moisture content, and the remaining 25% of the variations are related to other factors. Comparing the simulated and measured values at all sampling points shows that the average error of all the simulated values is 0.09, indicating that the simulation has high accuracy. The spatial distribution of soil moisture content is significantly affected by land use and topographic factors, and seasonal variation is remarkable in the year. Seasonal variation of soil moisture content is determined by the seasonal variation of rainfall and the air temperature (determining evaporation) and vegetation growth cycle. Therefore, the proposed model can simulate the spatial and temporal variation of soil moisture content and support developing the soil and water loss model on a basin scale.
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Cherny, Nathan I., Elisabeth G. E. de Vries, Urania Dafni, Elizabeth Garrett-Mayer, Shannon E. McKernin, Martine Piccart, Nicola J. Latino, et al. "Comparative Assessment of Clinical Benefit Using the ESMO-Magnitude of Clinical Benefit Scale Version 1.1 and the ASCO Value Framework Net Health Benefit Score." Journal of Clinical Oncology 37, no. 4 (February 1, 2019): 336–49. http://dx.doi.org/10.1200/jco.18.00729.
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PURPOSE To better understand the European Society for Medical Oncology-Magnitude of Clinical Benefit Scale version 1.1 (ESMO-MCBS v1.1) and the ASCO Value Framework Net Health Benefit score version 2 (ASCO-NHB v2), ESMO and ASCO collaborated to evaluate the concordance between the frameworks when used to assess clinical benefit attributable to new therapies. METHODS The 102 randomized controlled trials in the noncurative setting already evaluated in the field testing of ESMO-MCBS v1.1 were scored using ASCO-NHB v2 by its developers. Measures of agreement between the frameworks were calculated and receiver operating characteristic curves used to define thresholds for the ASCO-NHB v2 corresponding to ESMO-MCBS v1.1 categories. Studies with discordant scoring were identified and evaluated to understand the reasons for discordance. RESULTS The correlation of the 102 pairs of scores for studies in the noncurative setting is estimated to be 0.68 (Spearman’s rank correlation coefficient; overall survival, 0.71; progression-free survival, 0.67). Receiver operating characteristic curves identified thresholds for ASCO-NHB v2 for facilitating comparisons with ESMO-MCBS v1.1 categories. After applying pragmatic threshold scores of 40 or less (ASCO-NHB v2) and 2 or less (ESMO-MCBS v1.1) for low benefit and 45 or greater (ASCO-NHB v2) and 4 to 5 (ESMO-MCBS v1.1) for substantial benefit, 37 discordant studies were identified. Major factors that contributed to discordance were different approaches to evaluation of relative and absolute gain for overall survival and progression-free survival, crediting tail of the curve gains, and assessing toxicity. CONCLUSION The agreement between the frameworks was higher than observed in other studies that sought to compare them. The factors that contributed to discordant scores suggest potential approaches to improve convergence between the scales.
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Hameed, Akhtar, Muhammad Atiq, Zaheer Ahmed, Nasir Ahmed Rajput, Muhammad Younas, Abdul Rehman, Muhammad Waqar Alam, et al. "Predicting the impact of environmental factors on citrus canker through multiple regression." PLOS ONE 17, no. 4 (April 5, 2022): e0260746. http://dx.doi.org/10.1371/journal.pone.0260746.
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Climatic conditions play a significant role in the development of citrus canker caused by Xanthomonas citri pv. citri (Xcc). Citrus canker is regarded as one of the major threats being faced by citrus industry in citrus growing countries of the world. Climatic factors exert significant impacts on growth stage, host susceptibility, succulence, vigor, survival, multiplication rate, pathogen dispersion, spore penetration rate, and spore germination. Predicting the impacts of climatic factors on these traits could aid in the development of effective management strategies against the disease. This study predicted the impacts of environmental variables, i.e., temperature, relative humidity, rainfall, and wind speed the development of citrus canker through multiple regression. These environmental variables were correlated with the development of canker on thirty (30) citrus varieties during 2017 to 2020. Significant positive correlations were noted among environment variables and disease development modeled through multiple regression model (Y = +24.02 + 0.5585 X1 + 0.2997 X2 + 0.3534 X3 + 3.590 X4 + 1.639 X5). Goodness of fit of the model was signified by coefficient determination value (97.5%). Results revealed the optimum values of environmental variables, i.e., maximum temperature (37°C), minimum temperature (27°C), relative humidity (55%), rainfall (4.7–7.1 mm) and wind speed (8 Km/h), which were conducive for the development of citrus canker. Current study would help researchers in designing better management strategies against citrus canker disease under changing climatic conditions in the future.
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Robinson, John G., and Timothy G. O'Brien. "Allomaternal Care By Female Wedge-Capped Capuchin Monkeys: Effects of Age, Rank and Relatedness." Behaviour 119, no. 1-2 (1991): 30–50. http://dx.doi.org/10.1163/156853991x00355.
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AbstractWe examined patterns of infant care and the relative importance of female age, rank and relatedness to allomaternal care for a wild population of wedge-capped capuchin monkeys, Cebus olivaceus in Venezuela. Mothers interacted primarily with their own infants throughout the study. Infant age affected the timing and type of allomaternal interaction; investigation occurred primarily in the first 3 months of life, carrying was dominant during the second 3 months, and association occurred primarily in the third 3 months. The onset and level of allomaternal care assured a high level of infant care as maternal care was declining, suggesting that allomaternal care is an important component of infant survival. The relative importance of female age, rank and relatedness varied for different behaviour. Relatedness was the most consistently important effect. Sibling females participated in allomaternal care almost 4 times more often than other females and were especially active in carrying and associating with infants. Female rank was an important effect when the coefficient of relatedness was less than 0.5: high-ranking females participated in allomaternal care more than low-ranking females. Old juveniles and nulliparous adults interacted with infants more than young juveniles and parous adults, but the effect of female age was relatively unimportant. Allomaternal nursing may represent a form of reciprocal altruism. Allomaternal nursing supplemented maternal nursing and was unrelated to kinship or rank of female.
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Vidal, Liath, Irit Ben-Aharon, Shulamith Rizel, Rinat Yerushalmi, Aaron Sulkes, and Salomon M. Stemmer. "Bisphosphonates in the adjuvant setting of breast cancer therapy: Effect on survival—A systematic review and meta-analysis." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 548. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.548.
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548 Background: The role of bisphosphonates (BP) in the adjuvant setting in breast cancer has been evaluated in several studies, yielding inconsistent evidence. We performed a systematic review and meta-analysis of all randomized controlled trials (RCTs) that evaluate the effects of BP treatment on survival in patients with early breast cancer in the adjuvant setting. Methods: RCTs that compared BP therapy in addition to the standard adjuvant therapy (cytotoxic or hormonal) with standard adjuvant therapy only were identified by searching the Cochrane Library, LILACS, MEDLINE databases and conference proceedings (12.2011). Hazard ratios (HRs) of overall survival (OS), disease-free survival (DFS) and relative risks of adverse events were estimated and pooled. All statistical tests were two-sided. Results: Thirteen trials met the inclusion criteria., among which are the two recently published abstracts of large scale RCTs (NSABP-B34, GAIN) evaluating a total of 15,762 patients. Ten trials reported the OS outcome. Meta-analysis revealed no statistically significant benefit for BP (HR 0.89, 95% CI = 0.79 to 1.01). Nine trials reported the DFS outcome. Meta-analysis revealed no statistically significant better DFS for the intervention (HR 0.95 (0.80-1.11)). Six trials reported DFS stratified upon menopausal status. Postmenopausal patients who were treated with BP therapy had statistically significant better DFS than the control group (HR 0.81(0.69-0.95)). In meta-regression, chemotherapy was negatively associated with HR of OS (coefficient, -0.23; standard error, 0.144). BP therapy resulted in less fractures in the intervention arm, but higher incidence of osteonecrosis of the jaw and pyrexia. Conclusions: Our meta-analysis indicates a positive effect for adjuvant BP on survival outcomes only in postmenopausal patients with breast cancer. Meta-regression appraised the effect of confounders such as chemotherapy, showed a negative association between chemotherapy use and the effect of bisphosphonates on survival. Further large scale RCTs are warranted to unravel the specific subgroups and adjuvant treatments that would benefit from the addition of BP in the adjuvant setting.
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Prah, Melissa, Jennifer Connelly, and Kathleen Schmainda. "NIMG-54. LOW FRACTIONAL TUMOR BURDEN VOLUME OBTAINED FROM PERFUSION MRI REVEALS SIGNIFICANT SURVIVAL BENEFIT IN MGMT UNMETHYLATED GLIOBLASTOMA." Neuro-Oncology 24, Supplement_7 (November 1, 2022): vii176. http://dx.doi.org/10.1093/neuonc/noac209.672.
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Abstract INTRODUCTION Standard imaging remains inadequate for the determination of GBM response within the first 3 months following upfront chemoradiation therapy (CRT). Since advanced diffusion and DSC perfusion (pMRI) MRI are currently not included in RANO criteria, greater reliance is placed on MGMT methylation status, with methylated tumors demonstrating survival benefit. While pMRI has demonstrated usefulness following CRT, a newer pMRI biomarker termed Fractional Tumor Burden (FTB) provides both spatial and quantifiable information. The purpose of this study was to evaluate whether advanced MRI including FTB informs a survival benefit beyond MGMT promoter methylation status in newly diagnosed GBM (nGBM). METHODS Consented subjects with nGBM, and known MGMT status who completed standard upfront therapy and had MRI within 6 weeks of CRT completion, were included. Known IDH-mutant tumors were excluded. DSC was collected with the consensus protocol and leakage-corrected relative cerebral blood volume (rCBV) generated. Apparent diffusion coefficient (ADC) was calculated from diffusion MRI (b-value: 0,1000 s/mm2). FTB-defined tumor volumes were calculated from rCBV and delta T1w enhancement. Kaplan-Meier 24-month overall survival (OS) was evaluated for MGMT status and stratified by cohort mean for rCBV (1.3 a.u.) and ADC (1300 x10-6mm2/s), and empirically for FTB (5 ml) (significance: P >.05). RESULTS A total of 43 subjects were included (male/female=21/22; age=57(23-74)). MRI was acquired an average of 29 (12-42) days following CRT. Significant OS differences were confirmed for MGMT methylation (OS=19.08 vs. 10.18 mo; P=.0129). No significant survival differences were found (P >.05) when stratified by rCBV or ADC. While FTB did not provide further OS distinctions in methylated GBM, those with unmethylated MGMT had significant OS benefit when FTB volume was < 5 ml (OS=16.15 vs 8.39 mo; P=.0054). CONCLUSION FTB further informs OS in MGMT promoter unmethylated GBM, where those with lower volume had survival approaching that of methylated subjects.
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Sha, Ou, Yu Wang, Xin Yin, Xiaobing Chen, Li Chen, and Shujun Wang. "Magnetic Solid-Phase Extraction Using Fe3O4@SiO2 Magnetic Nanoparticles Followed by UV-Vis Spectrometry for Determination of Paraquat in Plasma and Urine Samples." Journal of Analytical Methods in Chemistry 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/8704639.
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A rapid and simple method was optimized and validated for the separation and quantification of paraquat, a frequently used herbicide and a leading cause of fatal poisoning worldwide, at trace levels with UV-Vis spectrophotometry in plasma and urine samples by direct magnetic solid-phase extraction. Fe3O4@SiO2 nanoparticles (NPs) were used as the magnetic solid-phase extraction agents and the paraquat absorbed on NPs was eluted using NaOH and ascorbic acid. Upon optimization, paraquat could be extracted and concentrated from various samples by 35-fold. The linear range, limit of detection (LOD), correlation coefficient (R), and relative standard deviation (RSD) could reach 15.0–400.0 μg/L, 12.2 μg/L, 0.9987, and 0.65% (n=5, c = 40.0 μg/L), respectively. The Fe3O4@SiO2 NPs could be reused up to five times. The method was successfully applied to the determination of paraquat in urine and plasma at different hemoperfusion numbers in a local hospital for the patient of paraquat poisoning. The experiment result could not only enable immediate medical intervention but also benefit patients’ survival.
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Llasaca Calizaya, Ehrlich Yam, Wendy del Rosario Vargas Callo, and Elizabeth Norka Llasaca Calizaya. "EVALUATION OF ZOOTECHNICAL PARAMETERS FOR FINGERLINGS OF Brycon cephalus SABALO COLA ROJA, IN THE COASTAL ZONE OF SOUTHERN PERU." REBIOL 42, no. 2 (April 19, 2023): 104–14. http://dx.doi.org/10.17268/rebiol.2022.42.02.05.
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In order to evaluate the zootechnical parameters for red-tailed tarpon Brycon cephalus fingerlings, in a region other than Amazonia, the evaluation of growth parameters in temperate waters was carried out for 60 days in the port of Ilo, Department of Moquegua. 84 fingerlings were used in 70 liters of water and two biometrics were performed, fluctuating in size from 3.5 cm to 9 cm at the end of the trial. Fingerlings were fed commercial trout feed of 45% protein, 8% fat and 25% carbohydrate, a feeding rate of 4.5% of biomass, distributed 3 times per day. The results reported as an average water temperature of 20.6°C, survival rate of 2.4%, growth determined by y=0.0155 X 2.8284 and a coefficient of determination of R²=0.975, average condition factor (K): 0.04393±0.0126 SD, Relative Growth Rate (TCR) of 9.5%, Specific Growth Rate (TCE) of 3.9% and Apparent Feed Conversion (CAA) of 1.4. With which it is observed that the parameters evaluated in the coastal zone of southern Peru are close to the native cultivation conditions.
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Xia, Haibin, Susana B. Adamo, Alex de Sherbinin, and Bryan Jones. "The Influence of Environmental Change (Crops and Water) on Population Redistribution in Mexico and Ethiopia." Applied Sciences 9, no. 23 (November 30, 2019): 5219. http://dx.doi.org/10.3390/app9235219.
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This paper discusses the effects of long-term environmental change (represented by the abundance or scarcity relative to the long-term average level of crop yield/river flow) and short-term environmental shock (represented by the maximum number of consecutive years below the median crop yield/river flow per decade) on population redistribution in Mexico and Ethiopia. Crop production and water resources, which are affected by climate change and influence human survival and activities, were selected as research variables. Two developing countries, namely, Mexico and Ethiopia, were selected as comparison cases. The results showed that short-term environmental shocks had no correlation with population redistribution. Short-term environmental shocks might fail to influence migration decisions or cause only temporary displacements that cannot be detected by demographic statistics. Among the long-term environmental change factors, only crop yield deviation was found to have a significant positive correlation with population redistribution. Based on two different datasets and two different decades, crop yield deviation is positively correlated with population redistribution; the correlation coefficients between crop yield deviation and population redistribution were 0.134 to 0.162 in Mexico and 0.102 to 0.235 in Ethiopia. When urbanization was considered as the control variable, the correlation coefficient between crop yield deviation and population redistribution in Mexico dropped by half, while it was almost the same in Ethiopia. However, Ethiopia’s population redistribution was more clearly influenced by the population itself. Crop yield deviation relative to water flow deviation meant changes in livelihoods. Population redistribution is a possible means of adapting to changes in livelihood. Mexico exhibited high resilience to changes in livelihoods caused by long-term environmental change, especially in its densely populated areas. In contrast, Ethiopia was characterized mainly by high population growth and low population migration. People in some areas of Ethiopia were forced to endure hardship of livelihood deterioration or to stay where they were due to the difficulty of obtaining sufficient resources to afford the cost of migration.
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Farazmand, Farzaneh, and Mahnaz Qomi. "Optimized Trace Analysis of Verapamil in Biological Fluids Using Solvent Bar Micro Extraction Technique Coupled with HPLC-UV Detection." Current Analytical Chemistry 16, no. 6 (August 13, 2020): 753–60. http://dx.doi.org/10.2174/1573411014666180730114456.
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Introduction: Verapamil (Verap) is an antidysrhythmic agent and a calcium channel blocker, indicated for angina, hypertension, supraventricular arrhythmias, and migraine. Objective: Drug monitoring plays a critical role in patient survival. In order to prevent the onset of drug toxicity, trace levels of this drug should be determined. Methods: For this reason, solvent bar microextraction technique coupled with high-performance liquid chromatography was implemented. Results: Under optimum condition, verapamil was micro-extracted from a donor solution (pH=11) to an acceptor solution (pH=3.2). It was transferred through n-octanol as the organic solvent, which was impregnated in the pores of the hollow fiber. Salt addition (30%) had the major effect on the efficiency of the method. Interaction of time (65 min), temperature (25°C), and stirring rate (818 rpm) had a significant effect too. It all resulted in a limit of detection and quantification of 15 ng mL-1 and 50 ng mL-1, respectively. The relative standard deviations of analysis were 4.9% within a day (n=3) and 5.7% between days (n=9). The calibration curves represented good linearity for urine and plasma samples with coefficient estimations higher than 0.99 with a linearity range of 50-5000 ng mL-1. The relative standard deviation for intra- (n=3) and inter-(n=9) day was 4.2% and 5.7%, respectively. Conclusion: It could be concluded that the application of this method for dose monitoring can be done at hospital and healthcare facilities.
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Awal, Md Rabiul, Subrina Nasrin, Md Ashikur Rahman, and Md Nahiduzzaman. "First record of important biological parameters of Badis badis: A small indigenous species in Bangladesh." Archives of Agriculture and Environmental Science 8, no. 2 (June 25, 2023): 228–35. http://dx.doi.org/10.26832/24566632.2023.0802020.
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A total of 286 Badis badis were collected from the Sutiyahali Reservoir in Mymensingh from January to December 2022, and their sex ratios, first sexual maturity, length-weight relationships and condition factors were evaluated. The weight and length of B. badis varied from 0.81 to 1.01g (0.89±0.30) and 4.08 to 4.60cm (4.36±0.31), respectively. Logistic curves depicting a sex ratio and 50% maturity (L50) estimated at 4.5cm for females and 4.05cm for males, as well as males reaching first sexual maturity with a shorter length than females. Regression coefficients in every month differ significantly (p<0.05), according to the regression equations. Each month, the values of the exponent b were less than 3 (b<3), with the highest value of b recorded in August (2.80) and the lowest value recorded in January (2.33). This led to a monthly negative allometric growth being seen. A strong positive relationship is evident from the coefficient of determination (r2) values, which ranged from 0.92-0.98 with an average of 0.961. During the study, the average condition factor (Kn) value for B. badis was found to be 1.02±0.13, which is a positive indicator of the fish's physical well-being. The condition factor values varied between 0.84 to 1.39, making it abundantly clear that B. badis are in good health and the waterbody is an ideal habitat for their survival. Relative condition factor (Kr) values, which varied between studies and ranged from 0.78 to 1.01, also exhibited a noteworthy difference (p<0.05). For its long-term management, the above findings will be very helpful.
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GOLI, SRINIVAS, and ABDUL C. P. JALEEL. "WHAT IS THE CAUSE OF THE DECLINE IN MATERNAL MORTALITY IN INDIA? EVIDENCE FROM TIME SERIES AND CROSS-SECTIONAL ANALYSES." Journal of Biosocial Science 46, no. 3 (October 22, 2013): 351–65. http://dx.doi.org/10.1017/s0021932013000564.
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SummaryStudies on the causes of maternal mortality in India have focused on institutional deliveries, and the association of socioeconomic and demographic factors with the decline in maternal mortality has not been sufficiently investigated. By using both time series and cross-sectional data, this paper examines the factors associated with the decline in maternal mortality in India. Relative effects estimated by OLS regression analysis reveal that per capita state net domestic product (−1.49611, p<0.05), poverty ratio (0.02426, p<0.05), female literacy rate (−0.05905, p<0.10), infant mortality rate and total fertility rate (0.11755, p<0.05) show statistically significant association with the decline in the maternal mortality ratio in India. The Barro-regression estimate reveals that improvements in economic and demographic conditions such as growth in state income (β=0.35020, p<0.05) and reduction in poverty (β=0.01867, p<0.01) and fertility (β=0.02598, p<0.05) have a greater association with the decline in the maternal mortality ratio in India than institutional deliveries (β=0.00305). The negative β-coefficient (β=−0.69578, p<0.05), showing the effect of the initial maternal mortality ratio on change in maternal mortality ratio in the Barro-regression model, indicates a greater decline in maternal mortality ratio in laggard states compared with advanced states. Overall, comparing the estimates of relative effects, the socioeconomic and demographic factors have a stronger statistically significant association with the maternal mortality ratio than institutional deliveries. Interestingly, the weak association between ‘increase in institutional deliveries' and ‘decline in maternal mortality ratio’ suggests that merely increasing deliveries alone will not help in ensuring maternal survival in India. Quality of services provided by the health facility, birth preparedness and avoiding delay in reaching health facility are also important. Deliveries in health facilities will not necessarily translate into increased survival chances of mothers unless women receive full antenatal care services and delays in reaching health facility are avoided.
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Li, Jin, Ruihua Xu, Yuxian Bai, Jianming Xu, Tianshu Liu, Lin Shen, Liwei Wang, et al. "Quality-adjusted time without symptoms or toxicity (Q-TWiST) of patients with metastatic colorectal cancer (mCRC) treated with fruquintinib in a phase II clinical trial." Journal of Clinical Oncology 36, no. 4_suppl (February 1, 2018): 765. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.765.
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765 Background: In a randomized phase II trial of mCRC patients who have failed at least 2 lines of standard therapy, fruquintinib has demonstrated superior progression free survival (PFS) and overall survival (OS) benefits over placebo. We further assessed the between-treatment difference of quality of life (QoL) using a Q-TWiST analysis, to elucidate the trade-off between adverse events and treatment benefits. Methods: Mean PFS and OS were estimated using the Kaplan-Meier method. OS in Q-TWiST analysis was partitioned into 3 health states: TOX (time with toxicity before progression), TWiST (time without symptoms or toxicity) and REL (time from progression until death). The algorism of Q-TWiST is the sum of the mean durations for the 3 health states, with each state weighted by its respective utility coefficient. The 95% confidence intervals of mean are calculated with z method and the standard error is generated by bootstrap method. The relative Q-TWiST gains of > = 10% and > = 15% are considered as a clinically important and clearly clinically important, respectively (Revicki, 2006). Results: A total of 71 patients were included in this post-hoc analysis. The 47 patients of fruquintinib arm had significant longer PFS, compared with the 24 patients in the placebo arm (mean: 5.0 vs. 2.2 months, difference [95% CI]: 2.8 [1.4, 4.3]). The benefit of OS was numerically superior (mean: 8.6 vs. 6.9 months, difference [95% CI]: 1.7 [-0.5, 4.0]). Patients treated with fruquintinib showed numerically longer overall Q-TWiST (mean: 5.8 vs. 4.4 months, difference [95% CI]: 1.4 [-0.1, 2.9] than those received placebo with the relative gain of 20.3% over OS, assuming the utility during TOX/REL period is 0.5 and that during the TWiST is 1.0. Sensitivity analysis demonstrated that the Q-TWiST gain may range from -0.7% to 41.2% at various utility assignments. Conclusions: In this phase II trial, mCRC patients treated with fruquintinib had clearly clinically important QoL benefit. Further studies with larger sample size are needed to confirm this finding. Clinical trial information: NCT02196688.
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Sampson, John, Achal Singh Achrol, Manish Aghi, Krystof Bankiewicz, Steven Brem, Andrew Brenner, Nicholas Butowski, et al. "ATIM-30. COMBATING RECURRENT GLIOBLASTOMA WITH MDNA55, AN INTERLEUKIN-4 RECEPTOR TARGETED IMMUNOTHERAPY, THROUGH MRI-GUIDED CONVECTIVE DELIVERY." Neuro-Oncology 21, Supplement_6 (November 2019): vi8. http://dx.doi.org/10.1093/neuonc/noz175.029.
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Abstract MDNA55, an IL4R-directed toxin, is being studied in a Phase 2b trial in recurrent GBM (rGBM) patients at first or second relapse. MDNA55 is co-infused with Gadolinium-based contrast agent and delivered as a single intratumoral infusion using Convection Enhanced Delivery (CED). Primary endpoint is median Overall Survival (mOS) and secondary endpoint is objective response rate (ORR) assessed by mRANO-based criteria incorporating advanced imaging modalities. Enrollment is complete (n=46). Current safety data show similar profile to previous MDNA55 trials with no systemic toxicities or drug related deaths. Current mOS in subjects treated with low doses of MDNA55 (median 63µg; n=21) is 11.8 months. When stratified by IL4R expression, a biomarker for more aggressive GBM, IL4R+ve subjects (mOS 15.2 months; n=8) show a survival advantage of 7 months compared to IL4R-ve subjects (mOS 8.1 months; n=10). Updated survival and response outcomes including subjects receiving the high dose (median 180µg; n=25) and stratification by IL4R expression will be reported. Review of serial imaging within 90 days following MDNA55 treatment demonstrated tumor shrinkage or stabilization from baseline in 19/42 evaluable subjects (disease control rate of 45%). To account for initial pseudo-progression in some subjects, tumor response was also assessed from nadir: 83% (35/42) showed disease control. Multi-parametric MRI biomarkers including relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC) measurements demonstrated distinct imaging phenotypes among different disease states (pseudo-progression vs true-progression, pseudo-response vs true-response) and improved response staging. This trial is advancing neurosurgical methods for CED, potential of IL4R expression as a biomarker to select GBM patients most likely to benefit from MDNA55 treatment, and optimal use of multi-parametric MRI as an adjunct to clinical decision making. The improved survival and disease control seen after only a single infusion of MDNA55, especially in IL4R+ve subjects, may provide promising clinical benefit for rGBM patients.
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Pronina, G. I., E. V. Bubunets, A. P. Glebov, and R. V. Zhelankin. "Effect of the probiotic “Enzimsporin” on the morphophysiological parameters of the Lena sturgeon and beluga hybrid in aquaculture." Izvestiâ Timirâzevskoj selʹskohozâjstvennoj akademii, no. 2 (2023): 144–53. http://dx.doi.org/10.26897/0021-342x-2023-2-144-153.
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The use of probiotics is recommended for sustainable growth, increased resistance and efficiency of feed assimilation. Currently, there are commercial probiotic products prepared from the bacteria Bacillus sp., Lactobacillus sp., Enterococcus sp., Carnobacterium sp. The use of the probiotic supplement “Enzimsporin” in fish farming is in its infancy. However, information is available on the effectiveness of its use in rainbow trout. In this regard, an urgent task is to study the effect of the probiotic “Enzimsporin” on the morphophysiological parameters of the juvenile hybrid of Lena sturgeon and beluga (Lenbel) under existing cultivation conditions. At the initial stage, the fish were divided into 8 groups of 50 fish each according to the principle of pairs of analogues. Large and small individuals were divided into four groups: control and experimental with a dose of Enzimsporin of 1 g/kg, 1.5 g /kg and 2 g/kg of feed, respectively. The duration of the experiment was 60 days. Total catches were made at the beginning and end of the experiment, and intermediate catches were made every 15 days, individually weighing 25–35% of the total number of fish in the pool. The physiological state and immune status of Lenbel were assessed by hematological and cytochemical parameters. Blood for analysis was collected from the caudal vein of fish in vivo. Leukocyte composition and the proportion of immature cell types were determined in Pappenheim-stained peripheral blood smears under a digital microscope. The phagocytic activity of fish neutrophils was evaluated by a lysosomal cation test using a cytochemical method with bromophenol blue. During the two months of the experiment, the main hydrochemical parameters (pH, nitrites, nitrates, ammonium), water temperature and the dissolved oxygen content were within the technological norms. The best absolute and relative growth rates were obtained in the experimental groups receiving a probiotic at a dose of 1.5 g/kg of feed. These fish had high indicators: absolute and relative growth, absolute and relative growth rate, mass accumulation coefficient. The best survival rate was recorded in the group of small yearlings of Lenbel at a probiotic dose of 2 g/kg of feed. In large fish, the maximum survival rate (80%) was recorded at a dose of 1 g/kg of “Enzimsporin”. There is significantly more lysosomal cationic protein in the blood neutrophils of the experimental groups – activation of cellular immunity.
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Garbajs, Manca, Primoz Strojan, and Katarina Surlan-Popovic. "Prognostic role of diffusion weighted and dynamic contrast-enhanced MRI in loco-regionally advanced head and neck cancer treated with concomitant chemoradiotherapy." Radiology and Oncology 53, no. 1 (March 3, 2019): 39–48. http://dx.doi.org/10.2478/raon-2019-0010.
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Abstract Background In the study, the value of pre-treatment dynamic contrast-enhanced (DCE) and diffusion weighted (DW) MRI-derived parameters as well as their changes early during treatment was evaluated for predicting disease-free survival (DFS) and overall survival (OS) in patients with locoregionally advanced head and neck squamous carcinoma (HNSCC) treated with concomitant chemoradiotherapy (cCRT) with cisplatin. Patients and methods MRI scans were performed in 20 patients with locoregionally advanced HNSCC at baseline and after 10 Grays (Gy) of cCRT. Tumour apparent diffusion coefficient (ADC) and DCE parameters (volume transfer constant [Ktrans], extracellular extravascular volume fraction [ve], and plasma volume fraction [Vp]) were measured. Relative changes in parameters from baseline to 10 Gy were calculated. Univariate and multivariate Cox regression analysis were conducted. Receiver operating characteristic (ROC) curve analysis was employed to identify parameters with the best diagnostic performance. Results None of the parameters was identified to predict for DFS. On univariate analysis of OS, lower pre-treatment ADC (p = 0.012), higher pre-treatment Ktrans (p = 0.026), and higher reduction in Ktrans (p = 0.014) from baseline to 10 Gy were identified as significant predictors. Multivariate analysis identified only higher pre-treatment Ktrans (p = 0.026; 95% CI: 0.000–0.132) as an independent predictor of OS. At ROC curve analysis, pre-treatment Ktrans yielded an excellent diagnostic accuracy (area under curve [AUC] = 0.95, sensitivity 93.3%; specificity 80 %). Conclusions In our group of HNSCC patients treated with cisplatin-based cCRT, pre-treatment Ktrans was found to be a good predictor of OS.
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Ginwal, H. S., P. S. Rawat, and R. L. Srivastava. "Seed Source Variation in Growth Performance and Oil Yield of Jatropha curcas Linn. in Central India." Silvae Genetica 53, no. 1-6 (December 1, 2004): 186–92. http://dx.doi.org/10.1515/sg-2004-0034.
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Abstract Results of a seed source evaluation trial of Jatropha curcas Linn. laid out in 1996 at Jabalpur (M.P), a semi arid region of India are reported and discussed. Seeds collected from ten sources from central India representing the states Madhya Pradesh and Maharashtra viz. Gondia, Bichia, Balaghat, Niwas, Khandwa, Burhanpur, Nasik, Chindwara, Kundam and Jabalpur were evaluated for their growth performance from nursery stage (3 months) to field (two years). Variation in seed oil content of different sources were also studied and reported. Significant differences between the seed sources at age 27 months were observed for height, collar diameter, number of branches leaf area and field survival. Seeds collected from different sources also varied significantly in respect of seed and kernel weight and oil content in seed/kernel. The Chhindwara (M.P.) source performed the best and yielded a maximum oil of 39.12% from whole seed and 58.12% from kernel. The oil content ranged from 33.02 to 39.12% in whole seeds and 47.08 to 58.12% in kernel, across the seed sources. The performance of Kundam (M.P.), Jabalpur (M.P.), Bichia (M.P.), Niwas (M.P.) and Nasik (Maharashtra) sources were also found satisfactory for oil yield. Results indicate that genetic differences exist between the seed sources of J. curcas. The growth traits showed significant positive correlation with each other. Fair differences between phenotypic and genotypic coefficient of variability were observed. Heritability (broad sense) values were fairly good with regard to leaf area, height and collar diameter in comparison to survival percent. The relative performance of these sources was fairly consistent throughout the observation period.
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Zhang, Maomao, Abdulla-Al Kafy, Bing Ren, Yanwei Zhang, Shukui Tan, and Jianxing Li. "Application of the Optimal Parameter Geographic Detector Model in the Identification of Influencing Factors of Ecological Quality in Guangzhou, China." Land 11, no. 8 (August 12, 2022): 1303. http://dx.doi.org/10.3390/land11081303.
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The ecological environment is important for the survival and development of human beings, and objective and accurate monitoring of changes in the ecological environment has received extensive attention. Based on the normalized difference vegetation index (NDVI), wetness (WET), normalized differential build-up and bare soil index (NDBSI), and land surface temperature (LST), the principal component analysis method is used to construct a comprehensive index to evaluate the ecological environment’s quality. The R package “Relainpo” is used to estimate the relative importance and contribution rate of NDVI, WET, NDBSI, and LST to the remote sensing ecological index (RSEI). The optimal parameter geographic detector (OPGD) model is used to quantitatively analyze the influencing factors, degree of influence, and interaction of the RSEI. The results show that from 2001 to 2020, the area with a poor grade quality of the RSEI in Guangzhou decreased from 719.2413 km2 to 660.4146 km2, while the area with an excellent quality grade of the RSEI increased from 1778.8311 km2 to 1978.9390 km2. The NDVI (40%) and WET (35%) contributed significantly to the RSEI, while LST and NDBSI contributed less to the RSEI. The results of single factor analysis revealed that soil type have the greatest impact on the RSEI with a coefficient (Q) of 0.1360, followed by a temperature with a coefficient (Q) of 0.1341. The interaction effect of two factors is greater than that of a single factor on the RSEI, and the interaction effect of different factors on the RSEI is significant, but the degree of influence is not consistent. This research may provide new clues for the stabilization and improvement of ecological environmental quality.
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Yun, Jae-Pil, Cheolwon Suh, Eunkyoung Lee, Jai Won Chang, Won Seok Yang, Jung Sik Park, and Su-Kil Park. "Creatinine Clearance Is More Important Prognostic Factor Than ß2 Microglobulin in Multiple Myeloma." Blood 104, no. 11 (November 16, 2004): 4864. http://dx.doi.org/10.1182/blood.v104.11.4864.4864.
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Abstract In the new staging system of multiple myeloma (MM) by South West Oncology Group (SWOG), the concentration of serum β2 microglobulin (β2m) and serum albumin were focused as the most important prognostic factors for survival. However, serum concentration of β2m has been known as an indicator of glomerular filtration rate. The aim of this study was to compare the prognostic value of the level of β2m with that of creatinine clearance (Ccr) in patients with multiple myeloma. Retrospectively, from January 1, 1996 to November 30, 2003, we reviewed 176 MM patients (M: F 110:66 mean age: 58.5±11.0) whose 24-hour urinary creatinine clearance was available at the time of diagnosis. We collected clinical data such as hemoglobin, serum creatinine, calcium, albumin, β2m, creatinine clearance before chemotherapies, and patients’ survival time. Pretreatment β2m was inversely related to Ccr (Spearman’s correlation coefficient = −0.781, P <0.01). In univariate analysis, relative risk (RR) of death was 1.047 (p< 0.001) for β2m and 0.985 (p< 0.001) for Ccr. But multivariate analysis using Cox’s proportional hazard model showed β2m was not significant prognostic factor in patients’ survival after adjustment for Ccr (RR 1.025, p=0.054) but Ccr was an independent risk factor of death after adjustment for β2m (RR 0.990, p=0.013). And univariate analysis identified that RR for β2m is not significant in 88 MM patients (66 patients with β2m ≥ 2.5mg/l) with relatively normal renal function (Ccr ≥ 50 ml/min) (RR = 1.110, p=0.306) We could propose another new staging system with β2m replaced by Ccr in SWOG staging system. The stages were defined as: stage 1, Ccr ≥ 80ml/min; stage 2, 50< Ccr <80; stage 3, Ccr < 50 and albumin ≥ 3.0g/dl; and stage 4 Ccr < 50 ml/min and albumin< 3.0 g/dl. According to this proposed staging system, median survival time of each stage from 1 to 4 is 1475, 887, 513, and 196 days, respectively. (Log Rank test < 0.0001) In conclusion, Ccr could be more important prognostic factor than the level of β2m in patients of MM and we propose that Ccr should be reassessed as the component of staging system of MM.