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Journal articles on the topic 'Rel01'

Author: Grafiati

Published: 29 July 2024

Last updated: 30 July 2024

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1

Ferreira, Denilson, and Peterson Gandolfi. "O planejamento financeiro familiar como estratégia de empoderamento de uma comunidade economicamente vulnerável." Revista Em Extensão 17, no. 1 (August 14, 2018): 93–104. http://dx.doi.org/10.14393/ree-v17n12018-rel01.

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Sttocco, Eduardo, Emyr Bellaver, and Vilmair Zancanaro. "Infecções sexualmente transmissíveis e gravidez: conscientização dos jovens do ensino médio de uma escola pública estadual em Caçador, Santa Catarina." Revista Em Extensão 17, no. 2 (December 31, 2018): 110–22. http://dx.doi.org/10.14393/ree-v17n22018-rel01.

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3

Carvalho, Márcio. "A POPULAÇÃO GOIANAENSE COMO GUARDIÃ DO PATRIMÔNIO CULTURAL." Revista de Educação Popular 12, no. 1 (June 30, 2013): 113–22. http://dx.doi.org/10.14393/rep-v12n12013-rel01.

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Paim, Bruno, and Milena Sousa. "Coletivo (RE)Ação: um projeto popular na zona leste de Uberlândia, Minas Gerais." Revista de Educação Popular 12, no. 2 (December 31, 2013): 115–22. http://dx.doi.org/10.14393/rep-v12n22013-rel01.

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5

Florentino, Bruno, and Angra Florentino. "CRAS ITINERANTE: UMA PROPOSTA DE BUSCA ATIVA, TERRITORIAL, DESCENTRALIZADA E INTERDISCIPLINAR." Revista de Educação Popular 13, no. 1 (June 30, 2014): 111–24. http://dx.doi.org/10.14393/rep-v13n12014-rel01.

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6

Lima, Eduardo, Daniel Pinheiro, and Patrícia Lima. "Implantação de experimentos ligados à ciência do solo em áreas de produtores rurais: um diálogo contínuo entre comunidade e universidade." Revista de Educação Popular 13, no. 2 (December 31, 2014): 187–97. http://dx.doi.org/10.14393/rep-v13n22014-rel01.

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Geniake, Luiz, Josiane Lima, Geovane Lourenço, and Lidia Zarpellon. "Oficinas educativas com gestantes: uma intervenção na Unidade de Saúde da Família." Revista de Educação Popular 14, no. 1 (July 18, 2015): 136–44. http://dx.doi.org/10.14393/rep-v14n12015-rel01.

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Bérgamo Florentino, Bruno Ricardo, and Angra dos Reis Florentino. "“Plantando sonhos”: serviço de convivência e inclusão produtiva do CRAS." Revista de Educação Popular 14, no. 2 (March 7, 2016): 165–79. http://dx.doi.org/10.14393/rep-v14n22015-rel01.

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González, Nicolás, and Jorge Martínez. "Asalariados rurales y acceso a la tierra: contradicciones y desafíos de una experiencia dialógica." Revista de Educação Popular 15, no. 1 (August 30, 2016): 128–40. http://dx.doi.org/10.14393/rep-v15n12016-rel01.

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Sousa-Lopes, Bruno. "A história de vida profissional de uma professora da educação básica: relatos de sua prática docente e do ambiente escolar." Revista de Educação Popular 15, no. 2 (December 2016): 128–36. http://dx.doi.org/10.14393/rep-v15n22016-rel01.

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11

Groppo, Luís, Evandro Rocha, Isabella Silveir, Maria Damasceno, Lívia Borges, Junior Trevisan, and Enzo Goussain. "A universidade, os jovens e o poder público na construção do Plano Municipal de Juventude de Alfenas, Minas Gerais." Revista de Educação Popular 16, no. 3 (January 9, 2018): 167–80. http://dx.doi.org/10.14393/rep-v16n32017-rel01.

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12

Costa, Fábio, Rosa Rigo, Maria Vitória, and Andreia Santos. "Oralidades em anotações de cordel: a produção de diários poéticos em aulas de escritura acadêmica." Revista de Educação Popular 17, no. 1 (June 18, 2018): 127–35. http://dx.doi.org/10.14393/rep-v17n12018-rel01.

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13

Grupioni, Christina, and Willer Barbosa. "GRAMADO-ESCOLA NA "TROCA DE SABERES/UFV": ALDEIA DE BAMBU E RESSURGÊNCIA PURI." Revista de Educação Popular 17, no. 2 (October 4, 2018): 181–92. http://dx.doi.org/10.14393/rep-v17n22018-rel01.

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De Aguiar Campos, Gustavo, and Mariana Cunha Pereira. "Cursinho Prepara Trans: possibilidade de articulação entre gênero e educação popular." Revista de Educação Popular 17, no. 3 (January 15, 2019): 183–94. http://dx.doi.org/10.14393/rep-v17n32018-rel01.

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A partir da experiência vivida no projeto denominado "Cursinho Prepara Transâ€, este texto tem como objetivo discutir a questão da diversidade sexual e de gênero no âmbito da educação popular. O projeto tem como objetivo preparar transexuais, travestis, lésbicas, bissexuais e gays (LGBT) para o Exame Nacional para Certificação de Competências de Jovens e Adultos (ENCCEJA), Exame Nacional do Ensino Médio (ENEM) e outros vestibulares. Com a experiência vivenciada em tal projeto foi possível discutir como, na prática popular, se faz necessário ter como norte as questões da diversidade e do preconceito além da conscientização e da transformação da realidade. Discutem-se, aqui, as perspectivas do diálogo, bem como da educação antirracista e da pedagogia feminista. Conclui-se que a inclusão e permanência de LGBT nos espaços educativos formais e informais se torna fundamental nos mais variados espaços.

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15

Nascimento, Marcelo. "Uma perspectiva em extensão universitária: programa de educação tutorial Pet-Biomecânica." Revista Em Extensão 14, no. 1 (July 18, 2015): 91–105. http://dx.doi.org/10.14393/ree-v14n12015-rel01.

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16

Zhang, Qiuxin, Dan He, Jingjing Zhang, Hui He, Guohua Guan, Tingting Xu, Weiyan Li, Yan He, and Zemin Zhang. "RIP5 Interacts with REL1 and Negatively Regulates Drought Tolerance in Rice." Cells 13, no. 11 (May 21, 2024): 887. http://dx.doi.org/10.3390/cells13110887.

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Improving the drought resistance of rice is of great significance for expanding the planting area and improving the stable yield of rice. In our previous work, we found that ROLLED AND ERECT LEAF1 (REL1) protein promoted enhanced tolerance to drought stress by eliminating reactive oxygen species (ROS) levels and triggering the abscisic acid (ABA) response. However, the mechanism through which REL1 regulates drought tolerance by removing ROS is unclear. In this study, we identified REL1 interacting protein 5 (RIP5) and found that it directly combines with REL1 in the chloroplast. We found that RIP5 was strongly expressed in ZH11 under drought-stress conditions, and that the rip5-ko mutants significantly improved the tolerance of rice plants to drought, whereas overexpression of RIP5 resulted in greater susceptibility to drought. Further investigation suggested that RIP5 negatively regulated drought tolerance in rice by decreasing the content of ascorbic acid (AsA), thereby reducing ROS clearance. RNA sequencing showed that the knockout of RIP5 caused differential gene expression that is chiefly associated with ascorbate and aldarate metabolism. Furthermore, multiple experimental results suggest that REL1 is involved in regulating drought tolerance by inhibiting RIP5. Collectively, our findings reveal the importance of the inhibition of RIP5 by REL1 in affecting the rice’s response to drought stress. This work not only explains the drought tolerance mechanism of rice, but will also help to improve the drought tolerance of rice.

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17

Dokoupil, Jakub, and Jiri Stary. "Effect of Temperature Cycling on IMC Growth and Solder Joint Strength of SAC305 Solder Alloy and Low Silver Alloy REL61." ECS Transactions 105, no. 1 (November 30, 2021): 391–400. http://dx.doi.org/10.1149/10501.0391ecst.

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This work deals with the comparison of the standard SAC305 (Sn 96.5 %; Ag 3 %; Cu 0.5 %) solder alloy with melting temperature between 217 - 220 °C and an alternative alloy REL61 (SnBiAgCu) with lower silver content and melting temperature in the range of 208 - 215 °C in terms of IMC layer growth during thermal cycling and its effect on the shear strength of the solder joints. The test PCBs were soldered using two different temperature profiles and the temperature cycling was performed under two different conditions. No negative effect of REL61 solder alloy on the growth of the IMC layer under thermal stress and on the subsequent shear strength of the solder joint was found. From this point of view, the REL61 solder alloy can be used as a replacement for the SAC305 solder alloy.

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18

Pornvipavee, Rachanid, Walter K. Kremers, Rachel A. Pedersen, Michelle Elliott, William J. Hogan, Ayalew Tefferi, and Mark Robert Litzow. "Allogeneic Stem Cell Transplantation (SCT) in Untreated First Relapse or Following Re-Induction Chemotherapy for Patients with Acute Myeloid Leukemia (AML)." Blood 104, no. 11 (November 16, 2004): 5143. http://dx.doi.org/10.1182/blood.v104.11.5143.5143.

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Abstract Background The timing of SCT for treatment of AML after first relapse is controversial, i.e.,whether to proceed to SCT at the time of relapse or to proceed to chemotherapy re-induction first in an attempt to reach a second remission. The purpose of this study is to determine the optimal time of allogeneic SCT in AML patients in first relapse by comparing outcomes of allogeneic SCT between patients untreated and patients post re-induction chemotherapy. Method This retrospective study was approved by the Mayo Foundation IRB. Between February 1983 and March 2003, 60 patients with AML in untreated first relapse (REL1) or post re-induction chemotherapy (CT) underwent allogeneic SCT in Mayo Clinic, Rochester. Study outcome included overall survival (OS), disease free survival (DFS), and transplant related mortality (TRM). The outcome was compared between the patients who underwent allogeneic SCT at REL1 and CT. Survival was analyzed using Kaplan-Meier (KM) and groups were compared statistically with the log-rank test. Result Of the 60 patients receiving allogeneic SCT , 25 patients and 35 patients underwent SCT at REL1 and CT, respectively. In the group of CT, 23 patients (66%) achieved CR2 while 12 patients (34%) had refractory disease. Forty-nine of 60 patients received cyclophosphamide and total body irradiation (Cy/TBI) as a conditioning regimen and the remainder received busulfan and cyclophosphamide( Bu/Cy). Patients in REL1 were older at SCT (median age 38 vs 31 years p= 0.024 ) and had lower percentage blast cells in bone marrow at first relapse (median 15% vs 50% p=0.00095) than in CT group. Difference in other baseline characteristics were not significant. KM analysis showed that the two groups did not show statistically differences in OS (p=0.43), DFS (p=0.68), and TRM (p=0.25). However, there were trends toward longer median OS (26.2 vs 5.4 months) and DFS (11.9 vs 3.3 months) with REL1 versus CT. OS at 1 year was 56 % for REL1 and 34.3 % for CT and at 5 year 32.1 % and 28.6 %, respectively. DFS at 1 year was 48 % for REL1 and 31.4 % for CT and at 5 years 22.9 % and 24.5 % respectively. TRM at 1 year was 25% for REL1 and 40 % for CT. A univariate Cox Proportional Hazard analysis for survival showed that unfavorable cytogenetics at diagnosis and relapse, antecedent MDS, and shorter duration of CR1 were significantly associated with a higher risk of death. Higher percentage of blast cells in bone marrow at first relapse was not significantly associated with a higher risk of death. In a multivariate model, unfavorable cytogenetics at first relapse and shorter duration of CR1 were both significantly associated with an increased risk of death. In this study, even after adjusting for other factors in a multivariate model, the difference between REL1 and CT groups was not statistically significant. Conclusion This study suggests that outcome of allogeneic SCT was comparable between REL1 and CT. Patients with AML in first relapse may proceed to allogeneic SCT because there appear to be no statistical differences in REL1 versus re-induction chemotherapy before SCT. REL1 patients tended to have a better outcome than CT patients.

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19

Petersen, F. B., M. H. Lynch, R. A. Clift, F. R. Appelbaum, J. E. Sanders, W. I. Bensinger, M. C. Benyunes, K. Doney, A. Fefer, and P. Martin. "Autologous marrow transplantation for patients with acute myeloid leukemia in untreated first relapse or in second complete remission." Journal of Clinical Oncology 11, no. 7 (July 1993): 1353–60. http://dx.doi.org/10.1200/jco.1993.11.7.1353.

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PURPOSE This study compares outcomes of autologous bone marrow transplantation (ABMT) in patients with acute myeloid leukemia (AML) in untreated first relapse (REL1) or in second complete remission (REM2). PATIENTS AND METHODS Forty-seven patients with AML in REL1 (n = 21) or in REM2 (n = 26) were treated with busulfan (BU) and cyclophosphamide (CY) with or without total-body irradiation (TBI) followed by ABMT. All REL1 patients and four REM2 patients had marrow stored during first remission (REM1). Twenty-seven had marrow stored with and 20 without treatment in vitro with 4-hydroperoxycyclophosphamide (4-HC). Eighteen patients received BU and CY and 29 received BU, CY, and TBI. REL1 patients relapsed within a median of 9 months (range, 2 to 26) after marrow harvest and were transplanted a median of 30 days (range, 9 to 87) from detection of relapse. RESULTS With a median follow-up of 2.1 years (range, 0.4 to 5.3), 19 patients survive in remission (10 of 21 in REL1; nine of 26 in REM2). The actuarial probabilities of relapse-free survival at 2 years for patients transplanted in REL1 and REM2 were 45% +/- 22% and 32% +/- 18%, respectively (P = .33). The corresponding probabilities of relapse were 30% +/- 26% and 44% +/- 23%, respectively (P = .45). No conclusions could be drawn about the benefits of adding TBI to BU plus CY. There were no significant differences in neutrophil or platelet recovery or in posttransplant probabilities of relapse and nonrelapse mortality between patients who received marrow treated or not treated with 4-HC. CONCLUSION These results suggest that ABMT may produce long-term leukemia-free survival in approximately one third of patients with AML in REL1 or in REM2. There is no apparent clinical advantage in attempting to obtain second remissions in relapsed patients before ABMT if marrow has been cryopreserved during REM1. Although a strategy of transplantation in REL1 has advantages for the patient, such an approach involves the storage of marrow, which may not be used, and is impractical without the coordinated support of the treating physician, the patient, and the marrow transplant center.

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20

Cusick, John K., Pachai Moua, George Talbott, Cara Sumida, and Aaron Jacobs. "RELT binds HIC and induces apoptosis by a mechanism distinct from TNFR1." Journal of Immunology 198, no. 1_Supplement (May 1, 2017): 201.21. http://dx.doi.org/10.4049/jimmunol.198.supp.201.21.

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Abstract Receptor Expressed in Lymphoid Tissues (RELT) is a human Tumor Necrosis Factor Receptor (TNFR) that is expressed most prominently in cells and tissues of the hematopoietic system. RELT has two identified homologous binding partners RELL1 and RELL2. This study sought to further elucidate the function of RELT by identifying novel protein interactions with RELT family members. Human I-mfa domain-containing protein (HIC), also known as MDFIC, was identified in a yeast two-hybrid genetic screen using RELL1 as bait. HIC is a transcription factor that was initially identified to differentially regulate HTLV and HIV gene expression. HIC is now known to regulate many other cellular processes and the hic gene is located proximally to regions of chromosome 7 (7q31.1) frequently lost in Acute Myeloid Leukemia (AML) patients. HIC physically interacts with both RELT and RELL1, as determined by in vitro co-immunoprecipitations. HIC co-localizes with RELL1 at the plasma membrane and co-localizes with RELT in intracellular compartments. Deletion mutants of RELT were utilized to determine regions of RELT required for both the activation of p38 and the induction of apoptosis in HEK-293 cells, two previously described functions of RELT. Co-immunoprecipitation experiments utilizing the deletion mutants indicate that regions of RELT proximal to the plasma membrane are sufficient for physical interaction with HIC. Overexpression of RELT induces cleavage of PARP and Caspase-3 as determined by western blotting. Interestingly, induction of apoptotic morphology by RELT overexpression was not prevented if signaling by FADD or Caspase-8 was blocked, indicating RELT induces apoptosis by a pathway distinct from death-domain containing TNFRs such as TNFR1.

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Metzger, S., G. Schreiber, E. Aizenman, M. Cashel, and G. Glaser. "Characterization of the relA1 mutation and a comparison of relA1 with new relA null alleles in Escherichia coli." Journal of Biological Chemistry 264, no. 35 (December 1989): 21146–52. http://dx.doi.org/10.1016/s0021-9258(19)30059-6.

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22

Tsai, Chia-Jung, and Joseph W. Saunders. "Somatic Embryos from Callus of Sugarbeet Biotechnology Clone REL1." Journal of Sugarbeet Research 32, no. 4 (October 1, 1995): 215–27. http://dx.doi.org/10.5274/jsbr.32.4.215.

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23

Feng, Lili, Jingping Hu, Wei Zhang, Yushu Dong, Sidong Xiong, and Chunsheng Dong. "RELL1 inhibits autophagy pathway and regulates Mycobacterium tuberculosis survival in macrophages." Tuberculosis 120 (January 2020): 101900. http://dx.doi.org/10.1016/j.tube.2020.101900.

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24

Cusick, John K., Anusri Yanumula, Yasmeen Alhomsy, Shymaa Bilasy, Dino Aghaians, Brittany Gillespie, Michelle Senderovich, et al. "Hematopoietic protein RELT stains prominently in breast cancer and binds the cytoskeletal protein Filamin A." Journal of Immunology 206, no. 1_Supplement (May 1, 2021): 56.02. http://dx.doi.org/10.4049/jimmunol.206.supp.56.02.

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Abstract Receptor Expressed in Lymphoid Tissues (RELT) is a human TNFR superfamily member expressed most prominently in cells and tissues of the hematopoietic system. Mouse knockout studies indicate that RELT functions in part by negatively regulating T-cell activation. RELT has two homologous binding partners, RELL1 and RELL2, and collectively, these proteins are described as RELT family members. This study sought to identify novel protein interactions with RELT family members and to compare the expression of RELT in normal and diseased tissues. A yeast two-hybrid screen utilizing RELL1 as bait identified the cytoskeletal protein Filamin A (FlnA); physical interaction between FlnA and RELT family members was confirmed by in vitro co-immunoprecipitation. A truncated mutant of FlnA disrupts the ability of RELT family members to activate the p38 pathway. Previous reports indicate that autoantibodies against RELT are associated with breast cancer and that RELL2 prevents migration and invasion of the metastatic breast cancer cell line MDA-MB-231 (231), while multiple studies suggest a link between FlnA and breast cancer. We therefore sought to examine the association of RELT family members with breast cancer. Western blotting revealed significant expression of endogenous RELT family members in the breast cancer cell lines 231 and MCF-7. Immunohistochemistry (IHC) revealed a higher intensity of RELT staining in breast cancer tissues versus normal mammary tissue. Additionally, overexpression of RELT family members enhanced apoptosis in 231 cells. Collectively, these results further our understanding of signal transduction pathways associated with RELT family members and provide evidence that RELT is upregulated in breast cancer.

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Cusick, John K., Yasmeen Alhomsy, George Talbott, Cara Sumida, Dino Aghaians, Nazila Hejazi, and Aaron Jacobs. "RELT stains prominently in B cell lymphomas and binds proteins associated with leukemia." Journal of Immunology 202, no. 1_Supplement (May 1, 2019): 194.12. http://dx.doi.org/10.4049/jimmunol.202.supp.194.12.

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Abstract Receptor Expressed in Lymphoid Tissues (RELT) is a human TNFR that is expressed prominently in the hematopoietic system and negatively regulates T-cell activation in mice. RELT has two identified homologous binding partners, RELL1 and RELL2. This study sought to further elucidate the function of RELT by identifying novel protein interactions with RELT family members and to study the localization of RELT in both normal and diseased tissues. A yeast two-hybrid screen identifed Phospholipid Scramblase 1 (PLSCR1) and MyoD family inhibitor domain-containing protein (MDFIC) as potential RELT-family member binding proteins that were confirmed by in vitro co-immunoprecipitations. PLSCR1 has been demonstrated to possess anti-leukemic properties, and RELT expression results in an altered cellular localization of PLSCR1 as determined by immunofluorescence (IF). The MDFIC gene encodes for a transcription factor and is located proximally to regions of chromosome 7 (7q31.1) frequently lost in AML patients. MDFIC was observed to co-localize with RELL1 at the plasma membrane and co-localize with RELT in intracellular compartments as determined by IF. Since RELT, PLSCR1 and MDFIC are prominently expressed in the hematopoietic system, we sought to characterize the expression of RELT in both normal lymph nodes and B cell lymphomas. Immunohistochemistry revealed a higher intensity of RELT staining in germinal centers in comparison to surrounding lymph node regions. Interestingly, the level of RELT staining increased progressively in low and high-grade B cell lymphomas versus normal lymph nodes. Collectively, these results further our understanding of proteins that interact with RELT and identify an association of RELT with B cell lymphomas.

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Jin, Xiaohong, Huiwen Xie, Xiaoman Liu, Qiuyan Shen, Ziheng Wang, Haiyan Hao, and Yan Gu. "RELL1, a novel oncogene, accelerates tumor progression and regulates immune infiltrates in glioma." International Immunopharmacology 87 (October 2020): 106707. http://dx.doi.org/10.1016/j.intimp.2020.106707.

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27

Cabral, Sara, Adriano de Paula, Richard Samuels, Rodrigo da Fonseca, Simone Gomes, José Roberto Silva, and Flávia Mury. "Aedes aegypti (Diptera: Culicidae) Immune Responses with Different Feeding Regimes Following Infection by the Entomopathogenic Fungus Metarhizium anisopliae." Insects 11, no. 2 (February 1, 2020): 95. http://dx.doi.org/10.3390/insects11020095.

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The mosquito Aedes aegypti is the most notorious vector of illness-causing viruses. The use of entomopathogenic fungi as bioinsecticides is a promising alternative for the development of novel mosquito control strategies. We investigate whether differences in immune responses could be responsible for modifications in survival rates of insects following different feeding regimes. Sucrose and blood-fed adult A. aegypti females were sprayed with M. anisopliae 1 × 106 conidia mL−1, and after 48 h, the midgut and fat body were dissected. We used RT-qPCR to monitor the expression of Cactus and REL1 (Toll pathway), IMD, REL2, and Caspar (IMD pathway), STAT and PIAS (JAK-STAT pathway), as well as the expression of antimicrobial peptides (Defensin A, Attacin and Cecropin G). REL1 and REL2 expression in both the midgut and fat body were higher in blood-fed fungus-challenged A. aegypti than in sucrose-fed counterparts. Interestingly, infection of sucrose-fed insects induced Cactus expression in the fat body, a negative regulator of the Toll pathway. The IMD gene was upregulated in the fat body in response to fungal infection after a blood meal. Additionally, we observed the induction of antimicrobial peptides in the blood-fed fungus-challenged insects. This study suggests that blood-fed A. aegypti are less susceptible to fungal infection due to the rapid induction of Toll and IMD immune pathways.

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Dziurdzia, Barbara, Maciej Sobolewski, Janusz Mikołajek, and Sebastian Wroński. "Low-voiding solder pastes in LED assembly." Soldering & Surface Mount Technology 32, no. 4 (May 1, 2020): 201–17. http://dx.doi.org/10.1108/ssmt-11-2019-0041.

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Purpose This paper aims to investigate voiding phenomena in solder joints under thermal pads of light-emitting diodes (LEDs) assembled in mass production environment by reflow soldering by using seven low-voiding lead-free solder pastes. Design/methodology/approach The solder pastes investigated are of SAC305 type, Innolot type or they are especially formulated by the manufacturers on the base of (SnAgCu) alloys with addition of some alloying elements such as Bi, In, Sb and Ti to provide low-void contents. The SnPb solder paste – OM5100 – was used as a benchmark. The solder paste coverage of LED solder pads was chosen as a measure of void contents in solder joints because of common usage of this parameter in industry practice. Findings It was found that the highest coverage and, related to it, the least void contents are in solder joints formed with the pastes LMPA-Q and REL61, which are characterized by the coverage of mean value 93.13% [standard deviation (SD) = 2.72%] and 92.93% (SD = 2.77%), respectively. The void diameters reach the mean value equal to 0.061 mm (SD = 0.044 mm) for LMPA-Q and 0.074 mm (SD = 0.052 mm) for REL61. The results are presented in the form of histograms, plot boxes and X-ray images. Some selected solder joints were observed with 3D computer tomography. Originality/value The statistical analyses are carried out on the basis of 2D X-ray images with using Origin software. They enable to compare features of various solder pastes recommended by manufacturers as low voiding. The results might be useful for solder paste manufacturers or electronic manufacturing services.

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Cusick, John K., Anusri Yanumula, Yennie Shyu, Wenjia Wang, Alyssa Abram, Jessa Alcaide, James Zhou, et al. "Hematopoietic protein RELT is upregulated in human breast and lung cancers and binds the cytoskeletal protein Filamin A." Journal of Immunology 208, no. 1_Supplement (May 1, 2022): 178.06. http://dx.doi.org/10.4049/jimmunol.208.supp.178.06.

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Abstract Receptor Expressed in Lymphoid Tissues (RELT), is a human TNFR superfamily member (TNFRSF19L) expressed most prominently in the hematopoietic system. Previous reports using RELT knockout mice indicate that RELT functions in part by inhibiting the proliferation and activation of T lymphocytes. RELT is an orphan receptor that has two homologous binding partners, RELL1 and RELL2, and collectively, these three proteins are referred to as RELT family members. This study sought to identify novel protein interactions with RELT family members and to compare the expression of RELT in normal and diseased human tissues. A yeast two-hybrid screen utilizing RELL1 as bait identified the cytoskeletal protein Filamin A (FLNA) as a prospective binding partner and physical interaction between FLNA and RELT family members was confirmed by in vitro co-immunoprecipitation. A truncated mutant of FLNA disrupts the ability of RELT family members to activate the p38 pathway and blocks the ability of RELT to induce death in human epithelial cells. Western blotting revealed endogenous RELT family members are most significantly upregulated in the breast cancer cell lines MDA-MB-231 and MCF-7, as well as the lung cancer cell line H358. Preliminary immunohistochemistry results reveal a higher intensity of RELT staining in both breast cancer and lung cancer human biopsies versus non-malignant tissue. Additionally, overexpression of RELT family members enhanced apoptosis in MDA-MB-231 and H358 cells as measured by X-gal morphology and luciferase assays. Collectively, these results further our understanding of signal transduction pathways associated with RELT family members and report the novel finding that RELT is upregulated in human breast and lung cancers. Supported by California Northstate University, College of Medicine, Seed Grant.

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Khanjani, Shirin, Vasso Terzidou, Yun S. Lee, Steve Thornton, Mark R. Johnson, and Phillip R. Bennett. "Synergistic Regulation of Human Oxytocin Receptor Promoter by CCAAT/ Enhancer-Binding Protein and RELA1." Biology of Reproduction 85, no. 5 (November 1, 2011): 1083–88. http://dx.doi.org/10.1095/biolreprod.111.092304.

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31

Goulard, Céline, Sophie Langrand, Elisabeth Carniel, and Sylvie Chauvaux. "The Yersinia pestis Chromosome Encodes Active Addiction Toxins." Journal of Bacteriology 192, no. 14 (May 14, 2010): 3669–77. http://dx.doi.org/10.1128/jb.00336-10.

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ABSTRACT Toxin-antitoxin (TA) loci consist of two genes in an operon, encoding a stable toxin and an unstable antitoxin. The expression of toxin leads to cell growth arrest and sometimes bacterial death, while the antitoxin prevents the cytotoxic activity of the toxin. In this study, we show that the chromosome of Yersinia pestis, the causative agent of plague, carries 10 putative TA modules and two solitary antitoxins that belong to five different TA families (HigBA, HicAB, RelEB, Phd/Doc, and MqsRA). Two of these toxin genes (higB2 and hicA1) could not be cloned in Escherichia coli unless they were coexpressed with their cognate antitoxin gene, indicating that they are highly toxic for this species. One of these toxin genes (higB2) could, however, be cloned directly and expressed in Y. pestis, where it was highly toxic, while the other one (hicA1) could not, probably because of its extreme toxicity. All eight other toxin genes were successfully cloned into the expression vector pBAD-TOPO. For five of them (higB1, higB3, higB5, hicA2, and tox), no toxic activity was detected in either E. coli or Y. pestis despite their overexpression. The three remaining toxin genes (relE1, higB4, and doc) were toxic for E. coli, and this toxic activity was abolished when the cognate antitoxin was coexpressed, showing that these three TA modules are functional in E. coli. Curiously, only one of these three toxins (RelE1) was active in Y. pestis. Cross-interaction between modules of the same family was observed but occurred only when the antitoxins were almost identical. Therefore, our study demonstrates that of the 10 predicted TA modules encoded by the Y. pestis chromosome, at least 5 are functional in E. coli and/or in Y. pestis. This is the first demonstration of active addiction toxins produced by the plague agent.

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Nagler, Arnon, Myriam Labopin, Johanna Tischer, Anna Maria Raiola, Desiree Kunadt, Jan Vydra, Didier Blaise, et al. "Non-T-Depleted Haploidentical Transplantation with Post-Transplant Cyclophosphamide in Patients with Relapsed/Refractory Secondary Versus De Novo AML: A Study from the ALWP/EBMT." Blood 142, Supplement 1 (November 28, 2023): 1049. http://dx.doi.org/10.1182/blood-2023-173636.

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Background: Secondary acute myeloid leukemia (sAML) is a distinct type of AML. Transplantation, a potentially curative therapy, outcomes are inferior compared to de novo AML. We recently demonstrated (J Hematol Oncol 2023) that results of non-T-cell depleted haploidentical stem cell transplantation (HaploSCT) with post-transplant cyclophosphamide (PTCy) in sAML in complete remission are not significantly different from those in denovo AML. However, the challenge in relapse (Rel)/primary refractory (PR) AML is much higher. Methods:The study aim was to compare the outcomes of HaploSCT with PTCy, performed between 2010 and 2022, in first Rel(Rel1)/PR sAML versus those in Rel1/PR de novo AML. Statistical tests included a multivariate analysis (MVA) adjusting for potential confounding factors using a Cox proportional-hazards regression model for main outcomes. Results: A total of 719 patients (pts) met the inclusion criteria, 129 with sAML and 590 with de novo AML. Median follow-up was 45.6 (IQR] 39.1-57.9) and 43.5 (IQR, 37.5-48.0) months for pts with sAML and de novo AML, respectively (p=0.20). Pts with de novo AML were younger, with a median age of 55.4 (range 18-77.8) versus 61.3 (21-78.8) years, (p<0.0001). The median year of the transplant was 2018 (2010-2011) in pts with sAML and 2017 (2010-2022) in those with de novo AML (p=0.62) and 65.1% and 57.6%, were male (p=0.11). In 81.4% of sAML pts, the antecedent hematological disorder was myelodysplastic syndrome. The cytogenetic risk was categorized as intermediate (58.6% vs 59.4%), adverse (37.4% vs 34.7%), and favorable (4% vs 5.9%) for pts with sAML and de novo AML, respectively (p=0.75) (data missing for 145 pts). A higher percentage of pts with sAML vs de novo AML had PR disease (73.6% vs 58.6%) (p=0.002). HCT-CI was higher in the sAML vs the de novo AML group, with HCT-CI >3 in 40.3% vs 21.9%, respectively (p<0.0001), while the Karnofsky performance status (KPS) did not differ. There was no difference in the frequency of cytomegalovirus (CMV) seropositivity and female donor to male pt combination between the two pt groups. Reduced intensity conditioning was received by 60.2% and 52.2% of the sAML and de novo AML pts, respectively (p=0.1), with thiotepa/busulfan/fludarabine being the most frequent regimen for both groups (38.8% vs 42%, respectively). Graft source was mainly peripheral blood stem cells (PB) in both sAML (69.8.5%) and de novo (66.8%) groups. All pts received PTCy as graft- versus-host disease (GVHD) prophylaxis in combination with immunosuppression, which was cyclosporine A (CSA)/ mycophenolate mofetil in 41.1% vs 52.9% and CSA/tacrolimus in 41.1% vs 33.6% respectively. Cumulative incidence of absolute neutrophil count (ANC) >0.5 x 10 9/L at day 60 was 83.5% vs 88.4% (p=0.13), respectively. Day 180 incidence of acute (a) GVHD II-IV and III-IV was 20% vs 26.9% (p=0.12) and 8.9% vs 10.4%, (p=0.21), respectively. The 2-year (y) total and extensive chronic (c) GVHD were 25.3% vs 20.7% (p=0.27) and 12.5 % vs 10.3% (p=0.46), respectively. In MVA HaploSCT outcomes did not differ significantly between the Rel1 /PR sAML and de novo groups; 2-y non-relapse mortality (NRM) hazard ratio (HR)=1.38 (95% CI 0.96-1.98, p=0.083). Infections and GVHD were the cause of death in 20.8% and 9.3% of pts who died. The HR for 2-y relapse incidence (RI) was 0.68 (95% CI 0.4.7.-1.00, p=0.051) and RI was the main cause of death in 40.9% and 59.3% of pts who died, respectively. The 2-y leukemia-free survival (LFS), overall survival (OS), and GVHD-free, relapse-free survival (GRFS) did not differ between the two groups with HR=0.99 (95% CI 0.76-1.28, p<0.94), HR=0.99 (95% CI 0.77-1.29, p=0.973) and HR=0.99 (95% CI 0.77-1.27, p=0.94), respectively. Adverse-risk cytogenetics was a poor prognostic factor for RI and both higher age (per 10y) and lower KPS were poor prognostic factors for NRM. Adverse-risk cytogenetics and lower KPS were poor prognostic factors for LFS, OS, and GRFS. In addition, pt CMV seropositivity was a poor prognostic factor for OS. Finally, PB grafts were associated with increased risk of all grades and severe aGVHD. Conclusions: In this registry-based retrospective analysis, we observed similar outcomes, of HaploSCT with PTCy for Rel1/PR sAML compared to Rel1/PR de novo AML, with HaploSCT being able to rescue about one-third of the pts. However, relapse is still 43%. The recently approved novel agents for sAML will hopefully further improve sAML outcomes.

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Shin, Sang Woon, Vladimir Kokoza, Guowu Bian, Hyang-Mi Cheon, Yu Jung Kim, and Alexander S. Raikhel. "REL1, a Homologue ofDrosophilaDorsal, Regulates Toll Antifungal Immune Pathway in the Female MosquitoAedes aegypti." Journal of Biological Chemistry 280, no. 16 (February 18, 2005): 16499–507. http://dx.doi.org/10.1074/jbc.m500711200.

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Signaling byDrosophilaToll pathway activates two Rel/NF-κB transcription factors, Dorsal (Dl) and Dorsal-related immune factor (Dif). Dl plays a central role in the establishment of dorsoventral polarity during early embryogenesis, whereas Dif mediates the Toll receptor-dependent antifungal immune response in adultDrosophila. The absence of a Dif ortholog in mosquito genomes suggests that Dl may play its functional role in the mosquito Toll-mediated innate immune responses. We have cloned and molecularly characterized the gene homologous toDrosophila Dland toAnopheles gambiae REL1(Gambif1) from the yellow fever mosquitoAedes aegypti, namedAaREL1.AaREL1alternative transcripts encode two isoforms,AaREL1-AandAaREL1-B. Both transcripts are enriched during embryogenesis and are inducible by septic injury in larval and female mosquitoes. AaREL1 and AaREL2 (AedesRelish) selectively bind to different κB motifs from insect immune gene promoters. Ectopic expression of AaREL1-A in bothDrosophilambn-2 cells and transgenic flies specifically activates Drosomycin and results in increased resistance against the fungusBeauveria bassiana. AaREL1-B acted cooperatively with AaREL1-A to enhance the immune gene activation in Aag-2 cells. The RNA interference knock-outs revealed that AaREL1 affected the expression ofAedeshomologue ofDrosophila Serpin-27Aand mediated specific antifungal immune response againstB. bassiana. These results indicate that the homologue of Dl, but not that of Dif, is a key regulator of the Toll antifungal immune pathway inA. aegyptifemale mosquitoes.

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Shokri, Atefeh, Andres Veide, and Gen Larsson. "RelA1 gene control of Escherichia coli lipid structure and cell performance during glucose limited fed-batch conditions." Applied Microbiology and Biotechnology 73, no. 2 (May 23, 2006): 464–73. http://dx.doi.org/10.1007/s00253-006-0480-9.

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Zimmermann, Stephan, Laurence Hall, Sean Riley, Jesper Sørensen, Rommie E. Amaro, and Achim Schnaufer. "A novel high-throughput activity assay for theTrypanosoma bruceieditosome enzyme REL1 and other RNA ligases." Nucleic Acids Research 44, no. 3 (September 22, 2015): e24-e24. http://dx.doi.org/10.1093/nar/gkv938.

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Nagamura-Inoue, Tokiko, Hideki Kodo, Tsuneo A. Takahashi, Hideo Mugishima, Arinobu Tojo, and Shigetaka Asano. "Four Cases of Donor Cell-Derived Acute Myeloid Leukemia Following Unrelated Cord Blood Transplantation for Adult Patients; Tokyo Cord Blood Bank Experiences." Blood 108, no. 11 (November 16, 2006): 3131. http://dx.doi.org/10.1182/blood.v108.11.3131.3131.

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Abstract Donor cell leukemia (DCL) is considered as a rare complication following allogeneic bone marrow transplantation (BMT), whereas the actual frequency of DCL has not yet been specified. Cord blood (CB) is now recognized as an alternative source for stem cell transplantation (SCT), with more than 6000 cord blood transplants (CBTs) performed worldwide, and a few cases of DCL following CBT have also been reported. Here we report four cases of DCL developed after unrelated CBTs using 490 shipped units from Tokyo cord blood bank (TCBB). Development of DCL was informed to TCBB by attending physicians of the recipients in CBT centers as soon as definite diagnosis was made. The feed-back from CBT centers on four DCL cases is summarized in Table 1. All the donors were well at the follow-up questionnaire 6–12 months after birth, but further information of their health conditions has not yet been obtained. Table 1. Four cases of DCL following CBT Case 1 2 3 4 Recipient 32F 32F 56F 30M Disease AML in REL1 AML-M0 in REL1 ATL Hodgkin’s disease SCT 1st 2nd 2nd 2nd Regimen Myeloablative Myeloablative Non-myeloablative Non-myeloablative TBI 12Gy 12Gy (−) 2Gy G-CSF (+) (+) (+) (+) GVHD prophylaxis CsA+sMTX CsA+sMTX FK506+PSL CsA+sMTX aGVHD II II 0 III cGVHD (−) (−) (−) limited DCL AML AML-M2 AML AML-M5 Latent period 15 Mm after CBT 11 Mm after CBT 7 Mm after CBT 16 Mm after CBT Diagnosis FISH STR FISH STR The etiology of DCL is unclear and a common mechanism is unlikely according to the reported literature. There exist several possibilities including occult leukemia or preleukemic state in the donor, defect in immune surveillance, therapy-related stromal abnormalities, excess of cytokine stimulation, and DNA replication and/or repair errors associated with post-transplant expansion of stem/progenitor cells. The possibility of occult leukemia in the donor raises serious problems regarding to the ethical responsibilities of the CBB to the donor.

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Huang, Hua-shan, Xiao-yan Huang, Hui-zhen Yu, Yan Xue, and Peng-li Zhu. "Circular RNA circ-RELL1 regulates inflammatory response by miR-6873-3p/MyD88/NF-κB axis in endothelial cells." Biochemical and Biophysical Research Communications 525, no. 2 (April 2020): 512–19. http://dx.doi.org/10.1016/j.bbrc.2020.02.109.

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38

Redruello-Guerrero, P. "Royal Colleges of Surgery of Barcelona and Madrid in the 18th century." ACTUALIDAD MEDICA 105, no. 105(811) (December 30, 2020): 202–8. http://dx.doi.org/10.15568/am.2020.811.rev01.

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On the occasion of the anniversary of the foundation of the Royal Colleges of Surgery of Barcelona and Madrid, this review presents the life and activity of both colleges, as well as the illustrious people who were in charge of them. The decline of surgery in the early 18th century prompted the creation of Royal Colleges of Surgery by the Bourbon Monarchy. The Royal College of Surgery of Barcelona, promoted by Pedro Virgili, with the previous experience he acquired at the Royal College of Surgery in Cádiz, was created with the intention of supplying the Royal Army of Spain with well-trained surgeons. The Royal College of Surgery of San Carlos in Madrid was inaugurated to use the training it offered to treat not only the military and sailors, but also the rest of the population. One of the most important figures in these institutions was Antonio Gimbernat, among others, whose life and academic career were linked to the evolution of the three Royal Colleges founded in Spain.

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Sanz-Serrulla, F. Javier. "Anastasio Chinchilla, Historian of Medicine, on the 150th Anniversary of his death." ANALES RANM 135, no. 01 (September 3, 2018): 8–12. http://dx.doi.org/10.32440/ar.2018.135.01.rev01.

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Díaz-Rubio, Manuel. "Professor Carlos Jiménez Díaz and the Spanish Royal Academy of Medicine." ANALES RANM 135, no. 02 (December 30, 2018): 119–24. http://dx.doi.org/10.32440/ar.2018.135.02.rev01.

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Marco, F., M. Galán-Olleros, and J. Mora-Fernández. "Hip fracture: A 21st century socio-sanitary epidemic in the first world." ANALES RANM 135, no. 03 (January 2, 2019): 203–10. http://dx.doi.org/10.32440/ar.2018.135.03.rev01.

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Fernández-Tresguerres Hernández, Jesús A., Emilce Insua-Nipoti, Paloma Castaño-Cambara, and Paloma Tejero-García. "Aesthetic and antiaging medicine." ANALES RANM 136, no. 01 (May 15, 2019): 7–8. http://dx.doi.org/10.32440/ar.2019.136.01.rev01.

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Ros, Pablo. "Integrated diagnosis (radiology, pathology and genetics): early experience." ANALES RANM 136, no. 02 (September 25, 2019): 99–102. http://dx.doi.org/10.32440/ar.2019.136.02.rev01.

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Maroto-Vela, María del Carmen, and Gonzalo Piédrola-Angulo. "Coronaviruses." ANALES RANM 136, no. 03 (March 5, 2020): 235–38. http://dx.doi.org/10.32440/ar.2019.136.03.rev01.

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Téllez-de-Peralta, Gabriel. "Mechanical respiratory support. ECMO. Liquid ventilation." ANALES RANM 137, no. 01 (May 4, 2020): 10–21. http://dx.doi.org/10.32440/ar.2020.137.01.rev01.

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Maroto Vela, María del Carmen. "SARS-CoV-2: Problems and uncertainties." ANALES RANM 137, no. 137(02) (September 30, 2020): 98–103. http://dx.doi.org/10.32440/ar.2020.137.02.rev01.

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Clavero Núñez, José Antonio. "COVID-19 infection in pregnancy. Assistance Care." ANALES RANM 137, no. 137(03) (December 30, 2020): 265–69. http://dx.doi.org/10.32440/ar.2020.137.03.rev01.

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In this work, we reviewed the care measures to wards pregnant women who are infected by SARS-CoV-2, in order to provide asistence during the pregnancy, the delivery and to the new born. The protocols proposed by the Ministry of Health, the Spanish Society of Obstetrics and Gynecology and others Cientific Societies in relation to the symptoms of COVID-19 are collected.

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Witt, Andrew C. "A Commentary on the PsalmsAllen P. Ross.A Commentary on the Psalms, volume 2 (42–89). Kregel Exegetical Library. Grand Rapids, MI: Kregel, 2013. Pp. 841,us$45.99.isbn9780825425639." Toronto Journal of Theology 31, no. 1 (January 2015): 137–38. http://dx.doi.org/10.3138/tjt.31.1.rev01.

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Gámez Millán, Sebastián. "Cosmopolitismo y pandemia. Reseña de: Adela Cortina, Ética cosmopolita. Una apuesta por la cordura en tiempos de pandemia, Barcelona; Paidós, 2021." Isegoría, no. 66 (July 13, 2022): r01. http://dx.doi.org/10.3989/isegoria.2022.66.res01.

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Revueltas-Jiménez, F., A. Pleguezuelos-Ventura, F. J. Martínez-Montoya, C. Delgado-Barrios, and P. Redruello-Guerrero. "Does ischemic cardiomyopathy behave differently in women? A holistic approach." ACTUALIDAD MEDICA 106, no. 106(814) (January 2022): 271–79. http://dx.doi.org/10.15568/am.2021.814.rev01.

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Ischemic heart disease is a clinically relevant entity in both men and women. However, differences have been observed in the pathophysiological mechanism in women, which determine a clinical presentation, risk factors and therapeutic treatments that may vary with respect to men. A narrative review has been carried out that reveals these differences in order to carry out a more optimal approach to ischemic cardiomyopathy in women.

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