Journal articles on the topic 'Rejection antibody-mediated'

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1

Karaveli, Guner, Ebru Gok Oguz, Tolga Yildirim, Zafer Ercan, Ozgur Merhametsiz, Ayhan Haspulat, and Deniz Ayli. "Plasmapheresis in Chronic Active Antibody-Mediated Rejection." Turkish Nephrology Dialysis Transplantation 24, no. 01 (January 26, 2015): 123–25. http://dx.doi.org/10.5262/tndt.2015.1001.20.

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2

Amore, Alessandro. "Antibody-mediated rejection." Current Opinion in Organ Transplantation 20, no. 5 (October 2015): 536–42. http://dx.doi.org/10.1097/mot.0000000000000230.

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3

Westall, Glen P., Miranda A. Paraskeva, and Greg I. Snell. "Antibody-mediated rejection." Current Opinion in Organ Transplantation 20, no. 5 (October 2015): 492–97. http://dx.doi.org/10.1097/mot.0000000000000235.

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4

Hogen, Rachel, Joseph DiNorcia, and Kiran Dhanireddy. "Antibody-mediated rejection." Current Opinion in Organ Transplantation 22, no. 2 (April 2017): 97–104. http://dx.doi.org/10.1097/mot.0000000000000391.

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5

Kittleson, Michelle M., and Jon A. Kobashigawa. "Antibody-mediated rejection." Current Opinion in Organ Transplantation 17, no. 5 (October 2012): 551–57. http://dx.doi.org/10.1097/mot.0b013e3283577fef.

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6

Arias, Manuel, David N. Rush, Chris Wiebe, Ian W. Gibson, Tom D. Blydt-Hansen, Peter W. Nickerson, Joana Sellarés, et al. "Antibody-Mediated Rejection." Transplantation 98 (August 2014): S3—S21. http://dx.doi.org/10.1097/tp.0000000000000218.

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7

Knechtle, Stuart. "Antibody‐Mediated Rejection." American Journal of Transplantation 20, S4 (June 2020): 1. http://dx.doi.org/10.1111/ajt.16063.

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8

Akalin, Enver, and Bruno Watschinger. "Antibody-Mediated Rejection." Seminars in Nephrology 27, no. 4 (July 2007): 393–407. http://dx.doi.org/10.1016/j.semnephrol.2007.05.001.

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9

Halverson, Laura P., and Ramsey R. Hachem. "Antibody-Mediated Rejection." Clinics in Chest Medicine 44, no. 1 (March 2023): 95–103. http://dx.doi.org/10.1016/j.ccm.2022.10.008.

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10

Papadimitriou, John C., Cinthia B. Drachenberg, Emilio Ramos, Debra Kukuruga, David K. Klassen, Richard Ugarte, Joseph Nogueira, Charles Cangro, Matthew R. Weir, and Abdolreza Haririan. "Antibody-Mediated Allograft Rejection." Transplantation Journal 95, no. 1 (January 2013): 128–36. http://dx.doi.org/10.1097/tp.0b013e3182777f28.

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11

Chin, Clifford. "Cardiac antibody-mediated rejection." Pediatric Transplantation 16, no. 5 (April 15, 2012): 404–12. http://dx.doi.org/10.1111/j.1399-3046.2012.01690.x.

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12

Arias, Manuel, Daniel Serón, Ignacio Herrero, David N. Rush, Chris Wiebe, Peter W. Nickerson, Piedad Ussetti, Emilio Rodrigo, and Maria-Angeles de Cos. "Subclinical Antibody-Mediated Rejection." Transplantation 101 (June 2017): S1—S18. http://dx.doi.org/10.1097/tp.0000000000001735.

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13

&NA;. "Antibody-Mediated Allograft Rejection." Transplantation Journal 95, no. 5 (March 2013): e30. http://dx.doi.org/10.1097/01.tp.0000427950.24640.c6.

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14

Zhang, Rubin. "Donor-Specific Antibodies in Kidney Transplant Recipients." Clinical Journal of the American Society of Nephrology 13, no. 1 (April 26, 2017): 182–92. http://dx.doi.org/10.2215/cjn.00700117.

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Donor-specific antibodies have become an established biomarker predicting antibody-mediated rejection. Antibody-mediated rejection is the leading cause of graft loss after kidney transplant. There are several phenotypes of antibody-mediated rejection along post-transplant course that are determined by the timing and extent of humoral response and the various characteristics of donor-specific antibodies, such as antigen classes, specificity, antibody strength, IgG subclasses, and complement binding capacity. Preformed donor-specific antibodies in sensitized patients can trigger hyperacute rejection, accelerated acute rejection, and early acute antibody-mediated rejection. De novo donor-specific antibodies are associated with late acute antibody-mediated rejection, chronic antibody-mediated rejection, and transplant glomerulopathy. The pathogeneses of antibody-mediated rejection include not only complement-dependent cytotoxicity, but also complement-independent pathways of antibody-mediated cellular cytotoxicity and direct endothelial activation and proliferation. The novel assay for complement binding capacity has improved our ability to predict antibody-mediated rejection phenotypes. C1q binding donor-specific antibodies are closely associated with acute antibody-mediated rejection, more severe graft injuries, and early graft failure, whereas C1q nonbinding donor-specific antibodies correlate with subclinical or chronic antibody-mediated rejection and late graft loss. IgG subclasses have various abilities to activate complement and recruit effector cells through the Fc receptor. Complement binding IgG3 donor-specific antibodies are frequently associated with acute antibody-mediated rejection and severe graft injury, whereas noncomplement binding IgG4 donor-specific antibodies are more correlated with subclinical or chronic antibody-mediated rejection and transplant glomerulopathy. Our in-depth knowledge of complex characteristics of donor-specific antibodies can stratify the patient’s immunologic risk, can predict distinct phenotypes of antibody-mediated rejection, and hopefully, will guide our clinical practice to improve the transplant outcomes.
15

Rascio, Federica, Paola Pontrelli, Giuseppe Stefano Netti, Elisabetta Manno, Barbara Infante, Simona Simone, Giuseppe Castellano, et al. "IgE-Mediated Immune Response and Antibody-Mediated Rejection." Clinical Journal of the American Society of Nephrology 15, no. 10 (September 9, 2020): 1474–83. http://dx.doi.org/10.2215/cjn.02870320.

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Background and objectivesActive antibody-mediated rejection is the main cause of kidney transplant loss, sharing with SLE the alloimmune response and the systemic activation of the IFN-α pathway. IgE-mediated immune response plays a key role in the development of SLE nephritis and is associated with IFN-α secretion. The aim of our study was to investigate IgE-mediated immune response in antibody-mediated rejection.Design, setting, participants, & measurementsThis was a cross-sectional study of 56 biopsy-proven antibody-mediated rejection study participants, 80 recipients with normal graft function/histology (control), 16 study participants with interstitial fibrosis/tubular atrophy, and six participants with SLE. We evaluated graft IgE deposition, tryptase (a mast cell marker), and CD203 (a specific marker of activated basophils) by immunofluorescence/confocal microscopy. In addition, we measured serum concentration of human myxovirus resistance protein 1, an IFN-α–induced protein, and anti-HLA IgE.ResultsWe observed a significantly higher IgE deposition in tubules and glomeruli in antibody-mediated rejection (1766±79 pixels) and SLE (1495±43 pixels) compared with interstitial fibrosis/tubular atrophy (582±122 pixels) and control (253±50 pixels). Patients with antibody-mediated rejection, but not control patients and patients with interstitial fibrosis/tubular atrophy, presented circulating anti-HLA IgE antibodies, although with a low mean fluorescence intensity. In addition, immunofluorescence revealed the presence of both mast cells and activated basophils in antibody-mediated rejection but not in control and interstitial fibrosis/tubular atrophy. The concentration of circulating basophils was significantly higher in antibody-mediated rejection compared with control and interstitial fibrosis/tubular atrophy. MxA serum levels were significantly higher in antibody-mediated rejection compared with control and correlated with the extent of IgE deposition.ConclusionsOur data suggest that IgE deposition and the subsequent recruitment of basophils and mast cells within the kidney transplant might play a role in antibody-mediated rejection.
16

Terasaki, Paul, and Kazuo Mizutani. "Antibody Mediated Rejection: Update 2006." Clinical Journal of the American Society of Nephrology 1, no. 3 (April 12, 2006): 400–403. http://dx.doi.org/10.2215/cjn.02311205.

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17

Adam, Benjamin A., and Howard M. Gebel. "IgE in Antibody-Mediated Rejection." Clinical Journal of the American Society of Nephrology 15, no. 10 (September 9, 2020): 1392–93. http://dx.doi.org/10.2215/cjn.13000820.

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18

Colvin, R. B. "Dimensions of Antibody-Mediated Rejection." American Journal of Transplantation 10, no. 7 (April 23, 2010): 1509–10. http://dx.doi.org/10.1111/j.1600-6143.2010.03172.x.

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19

Colvin, Robert B., and R. Neal Smith. "Antibody-mediated organ-allograft rejection." Nature Reviews Immunology 5, no. 10 (September 20, 2005): 807–17. http://dx.doi.org/10.1038/nri1702.

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20

Baldwin, William, and Anna Valujskikh. "Mechanisms Underlying Antibody-Mediated Rejection." Circulation 141, no. 6 (February 11, 2020): 479–81. http://dx.doi.org/10.1161/circulationaha.119.044541.

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21

Suhas, Bavikar, Oswal Ajay, and Swarnalata Gowrishankar. "Antibody mediated rejection in KT." Indian Journal of Transplantation 8, no. 4 (October 2014): 132. http://dx.doi.org/10.1016/j.ijt.2014.12.020.

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22

Hachem, Ramsey. "Antibody-mediated lung transplant rejection." Current Respiratory Care Reports 1, no. 3 (June 27, 2012): 157–61. http://dx.doi.org/10.1007/s13665-012-0019-8.

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23

Vella, John P., and Alexander C. Wiseman. "Rejection: T Cell-Mediated and Antibody-Mediated." Nephrology Self-Assessment Program 18, no. 5 (November 2019): 297–302. http://dx.doi.org/10.1681/nsap.2019.18.5.8.

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24

Kvan, V. S., N. N. Koloskova, Yu A. Kachanova, N. N. Sayfullina, A. Yu Goncharova, L. B. Krugly, and A. O. Shevchenko. "Antibody-mediated rejection in heart transplantation." Russian Journal of Transplantology and Artificial Organs 23, no. 4 (November 12, 2021): 47–61. http://dx.doi.org/10.15825/1995-1191-2021-4-47-61.

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The role of antibody-mediated rejection in predicting survival among heart recipients has been studied in clinical transplantology for over 20 years. This condition is a significant risk factor for heart failure and graft vasculopathy. Antibody-mediated rejection results from activation of the humoral immune system and production of donorspecific antibodies that cause myocardial injury through the complement system. The presence of donor-specific antibodies is associated with lower allograft survival. Treatment of antibody-mediated rejection should take into account the rejection category and the presence or absence of graft dysfunction. The main principle of treatment is to suppress humoral immunity at different levels. World clinical practice has made significant inroads into the study of this issue. However, further research is required to identify and develop optimal treatment regimens for patients with humoral rejection in cardiac transplantation.
25

van Agteren, Madelon, Willem Weimar, Annelies E. de Weerd, Peter A. W. te Boekhorst, Jan N. M. Ijzermans, Jaqueline van de Wetering, and Michiel G. H. Betjes. "The First Fifty ABO Blood Group Incompatible Kidney Transplantations: The Rotterdam Experience." Journal of Transplantation 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/913902.

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This study describes the single center experience and long-term results of ABOi kidney transplantation using a pretransplantation protocol involving immunoadsorption combined with rituximab, intravenous immunoglobulins, and triple immune suppression. Fifty patients received an ABOi kidney transplant in the period from 2006 to 2012 with a follow-up of at least one year. Eleven antibody mediated rejections were noted of which 5 were mixed antibody and cellular mediated rejections. Nine cellular mediated rejections were recorded. Two grafts were lost due to rejection in the first year. One-year graft survival of the ABOi grafts was comparable to 100 matched ABO compatible renal grafts, 96% versus 99%. At 5-year follow-up, the graft survival was 90% in the ABOi versus 97% in the control group. Posttransplantation immunoadsorption was not an essential part of the protocol and no association was found between antibody titers and subsequent graft rejection. Steroids could be withdrawn safely 3 months after transplantation. Adverse events specifically related to the ABOi protocol were not observed. The currently used ABOi protocol shows good short and midterm results despite a high rate of antibody mediated rejections in the first years after the start of the program.
26

Rozentâls, Rafails, and Ieva Ziediņa. "Antibody-Mediated Rejection in Kidney Transplant Recipients." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences 67, no. 1 (April 1, 2013): 2–8. http://dx.doi.org/10.2478/prolas-2013-0001.

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This paper provides a review of the significant problem of humoral, or antibody-mediated rejection, in kidney transplantation. The main cause of antibody-mediated rejection is donor-specific anti-HLA antibodies. Patients with anti-HLA antibodies are called sensitised patients. The outcome of humoral rejection is unfavourable: graft dysfunction and failure have been frequent from the early post-transplant period and are continuing. International laboratories and clinics offer sensitive and accurate methods to determine antibodies before and after kidney transplantation, but the methods are not always successful in recognition of sensitised patients. For diagnostics of humoral rejection the important issue is detecting complement breakdown deposition (C4d) in peritubular capillaries during immunohistological examination. On the one hand, their presence is characteristic for humoral rejection, but on the other hand, they can occur without any clinical changes or can remain undetected during severe humoral rejection. Current methods of prevention, diagnostics and treatment of humoral rejection are discussed. Difficulties of evaluation of chronic antibody-mediated injury are particularly highlighted.
27

Halverson, Laura P., and Ramsey R. Hachem. "Antibody-Mediated Rejection and Lung Transplantation." Seminars in Respiratory and Critical Care Medicine 42, no. 03 (May 24, 2021): 428–35. http://dx.doi.org/10.1055/s-0041-1728796.

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AbstractAntibody-mediated rejection (AMR) is now a widely recognized form of lung allograft rejection, with mounting evidence for AMR as an important risk factor for the development of chronic lung allograft dysfunction and markedly decreased long-term survival. Despite the recent development of the consensus diagnostic criteria, it remains a challenging diagnosis of exclusion. Furthermore, even after diagnosis, treatment directed at pulmonary AMR has been nearly exclusively derived from practices with other solid-organ transplants and other areas of medicine, such that there is a significant lack of data regarding the efficacy for these in pulmonary AMR. Lastly, outcomes after AMR remain quite poor despite aggressive treatment. In this review, we revisit the history of AMR in lung transplantation, describe our current understanding of its pathophysiology, discuss the use and limitations of the consensus diagnostic criteria, review current treatment strategies, and summarize long-term outcomes. We conclude with a synopsis of our most pressing gaps in knowledge, introduce recommendations for future directions, and highlight promising areas of active research.
28

Gosset, Clément, Carmen Lefaucheur, and Denis Glotz. "New insights in antibody-mediated rejection." Current Opinion in Nephrology and Hypertension 23, no. 6 (November 2014): 597–604. http://dx.doi.org/10.1097/mnh.0000000000000069.

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29

Manfredini, Valentina, Ornella Leone, Valentina Agostini, and Luciano Potena. "Antibody-mediated rejection in heart transplantation." Current Opinion in Organ Transplantation 22, no. 3 (June 2017): 207–14. http://dx.doi.org/10.1097/mot.0000000000000407.

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30

Everly, Jason J., R. Carlin Walsh, Rita R. Alloway, and E. Steve Woodle. "Proteasome inhibition for antibody-mediated rejection." Current Opinion in Organ Transplantation 14, no. 6 (December 2009): 662–66. http://dx.doi.org/10.1097/mot.0b013e328330f304.

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31

Dick, André A. S., and Simon Horslen. "Antibody-mediated rejection after intestinal transplantation." Current Opinion in Organ Transplantation 17, no. 3 (June 2012): 250–57. http://dx.doi.org/10.1097/mot.0b013e3283533847.

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32

Shimizu, Akira, and Robert Colvin. "Pathological Features of Antibody-Mediated Rejection." Current Drug Target -Cardiovascular & Hematological Disorders 5, no. 3 (June 1, 2005): 199–214. http://dx.doi.org/10.2174/1568006054064744.

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33

Weissenbacher, Annemarie, Theresa Hautz, Bernhard Zelger, Bettina G. Zelger, Verena Mayr, Gerald Brandacher, Johann Pratschke, and Stefan Schneeberger. "Antibody-mediated rejection in hand transplantation." Transplant International 27, no. 2 (November 25, 2013): e13-e17. http://dx.doi.org/10.1111/tri.12233.

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34

Westall, Glen P., and Greg I. Snell. "Antibody-Mediated Rejection in Lung Transplantation." Transplantation 98, no. 9 (November 2014): 927–30. http://dx.doi.org/10.1097/tp.0000000000000392.

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35

Sage, Peter T. "Preventing Antibody-mediated Rejection During Transplantation." Transplantation 102, no. 10 (October 2018): 1597–98. http://dx.doi.org/10.1097/tp.0000000000002225.

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36

Sureshkumar, Kalathil K., Sabiha M. Hussain, Barbara J. Carpenter, Stephen E. Sandroni, and Richard J. Marcus. "Antibody-mediated rejection following renal transplantation." Expert Opinion on Pharmacotherapy 8, no. 7 (May 2007): 913–21. http://dx.doi.org/10.1517/14656566.8.7.913.

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37

Racusen, L. C. "Antibody-Mediated rejection in the kidney." Transplantation Proceedings 36, no. 3 (April 2004): 768–69. http://dx.doi.org/10.1016/j.transproceed.2004.03.032.

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38

Rose, Marlene L. "Antibody-mediated rejection following cardiac transplantation." Transplantation Reviews 7, no. 3 (July 1993): 140–52. http://dx.doi.org/10.1016/s0955-470x(05)80013-8.

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39

Kfoury, Abdallah G., Deborah Budge, Jose Nativi-Nicolau, Rami A. Alharethi, M. Elizabeth H. Hammond, and Dylan V. Miller. "Antibody-mediated Rejection in Heart Transplantation." Current Transplantation Reports 1, no. 4 (September 13, 2014): 246–56. http://dx.doi.org/10.1007/s40472-014-0029-2.

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40

Kulkarni, H. S., B. C. Bemiss, and R. R. Hachem. "Antibody-Mediated Rejection in Lung Transplantation." Current Transplantation Reports 2, no. 4 (September 30, 2015): 316–23. http://dx.doi.org/10.1007/s40472-015-0074-5.

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41

Lee, Michael. "Antibody-Mediated Rejection After Liver Transplant." Gastroenterology Clinics of North America 46, no. 2 (June 2017): 297–309. http://dx.doi.org/10.1016/j.gtc.2017.01.005.

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42

Bery, Amit I., and Ramsey R. Hachem. "Antibody-mediated rejection after lung transplantation." Annals of Translational Medicine 8, no. 6 (March 2020): 411. http://dx.doi.org/10.21037/atm.2019.11.86.

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43

Hachem, Ramsey R. "Acute Rejection and Antibody-Mediated Rejection in Lung Transplantation." Clinics in Chest Medicine 38, no. 4 (December 2017): 667–75. http://dx.doi.org/10.1016/j.ccm.2017.07.008.

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44

Puttarajappa, Chethan, Ron Shapiro, and Henkie P. Tan. "Antibody-Mediated Rejection in Kidney Transplantation: A Review." Journal of Transplantation 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/193724.

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Antibody mediated rejection (AMR) poses a significant and continued challenge for long term graft survival in kidney transplantation. However, in the recent years, there has emerged an increased understanding of the varied manifestations of the antibody mediated processes in kidney transplantation. In this article, we briefly discuss the various histopathological and clinical manifestations of AMRs, along with describing the techniques and methods which have made it easier to define and diagnose these rejections. We also review the emerging issues of C4d negative AMR, its significance in long term allograft survival and provide a brief summary of the current management strategies for managing AMRs in kidney transplantation.
45

Petty, Michael. "Antibody-Mediated Rejection in Solid Organ Transplant." AACN Advanced Critical Care 27, no. 3 (July 1, 2016): 316–23. http://dx.doi.org/10.4037/aacnacc2016366.

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Within a little more than a decade, the transplant of human organs for end-stage organ disease became a reality. The early barriers to successful long-term graft and patient survival were related to the inability to effectively control the immune system such that it would not attack the donor tissue but would still recognize and destroy invading organisms and cells. As immunosuppressive therapy has been refined and proper matching of donors and recipients has been improved, hyperacute rejection has become a rare occurrence and acute rejection has been markedly controlled. However, antibody-mediated rejection remains an important impediment to increased survival of transplanted organs. This article provides readers with a broad overview of the immune system, discusses mechanisms of transplant rejection, and details prevention, detection, and treatment of antibody-mediated rejection in solid organ transplant.
46

Arjuna, Ashwini, Michael T. Olson, Sofya Tokman, Rajat Walia, Thalachallour Mohanakumar, A. Samad Hashimi, Michael A. Smith, Ross M. Bremner, and Ashraf Omar. "Antibody-Mediated Rejection and Sponge Effect in a Redo Lung Transplant Recipient." Case Reports in Transplantation 2021 (June 10, 2021): 1–4. http://dx.doi.org/10.1155/2021/6637154.

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Long-term survival after lung transplant remains severely limited by chronic lung allograft dysfunction. Antibody-mediated rejection of lung transplant allografts is usually caused by donor-specific antibodies (DSAs) directed toward donor human leukocyte antigens (HLAs). Typically, patients with antibody-mediated rejection have significantly higher circulating DSAs and increased mean fluorescence intensity than those without antibody-mediated rejection. However, some patients with antibody-mediated rejection have low mean fluorescence intensities, partly due to the “sponge effect” related to DSAs binding to HLA molecules within the lung. Herein, we report the case of an 18-year-old, female lung transplant recipient who required retransplantation and developed circulating DSAs directed toward the first allograft but detected in circulation only after retransplantation. The present case draws attention to a rare finding of sponge effect in a patient with antibody-mediated rejection leading to allograft failure.
47

Aguilera Agudo, Cristina, Manuel Gómez Bueno, and Isabel Krsnik Castello. "Daratumumab for Antibody-mediated Rejection in Heart Transplant—A Novel Therapy: Successful Treatment of Antibody-mediated Rejection." Transplantation 105, no. 3 (February 22, 2021): e30-e31. http://dx.doi.org/10.1097/tp.0000000000003505.

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48

Tatar, Erhan, Adam Uslu, Cenk Simsek, and Enver Vardar. "Evaluation of Late Antibody-Mediated Rejection (C4d-Mediated Rejection): A Single-Center Experience." Experimental and Clinical Transplantation 13, Supplement 1 (April 1, 2015): 259–62. http://dx.doi.org/10.6002/ect.mesot2014.p67.

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49

Fekete, A. A., S. W. Yau, J. G. Youssef, A. Goodarzi, and H. J. Huang. "Antibody Mediated Rejection of Unrelated Donor Lung." Journal of Heart and Lung Transplantation 40, no. 4 (April 2021): S509. http://dx.doi.org/10.1016/j.healun.2021.01.2056.

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50

Bansal, SB. "Rituximab use in late antibody-mediated rejection." Indian Journal of Nephrology 26, no. 5 (2016): 315. http://dx.doi.org/10.4103/0971-4065.179305.

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