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Academic literature on the topic 'Registro Tumori'

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Published: 10 March 2023

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Journal articles on the topic "Registro Tumori"

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Fortunato, Nicola, and Paolo Sbraccia. "Neoplasie emergenti tra i giovani adulti negli Stati Uniti: analisi dei dati provenienti dal registro tumori del Nord America." L'Endocrinologo 20, no. 5 (September 17, 2019): 313–14. http://dx.doi.org/10.1007/s40619-019-00623-z.

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Ragusa, Rosalia, Antonina Torrisi, Alessia Anna Di Prima, Antonietta A. Torrisi, Antonella Ippolito, Margherita Ferrante, Anselmo Madeddu, and Vincenzo Guardabasso. "Cancer Prevention for Survivors: Incidence of Second Primary Cancers and Sex Differences—A Population-Based Study from an Italian Cancer Registry." International Journal of Environmental Research and Public Health 19, no. 19 (September 26, 2022): 12201. http://dx.doi.org/10.3390/ijerph191912201.

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Background: The number of cancer survivors continues to increase, thanks to advances in cancer diagnosis and treatment. Unfortunately, the incidence of a second primary cancer (SPC) is also increasing, but limited studies reporting incidence data are available regarding multiple cancers. This study presents our observations on multiple primary malignant cancers, the associations between sites, and the inherent sex differences. Patients and methods: We report the data, disaggregated by sex, concerning the SPCs that were recorded in the “Registro Tumori Integrato” (RTI) a population-based cancer registry in Sicily, Italy, as observed in the period from 2003 to 2017, in a total population of approximately 2,300,000. SPCs were divided into synchronous and metachronous cancers. The International Classification of Diseases for Oncology, third edition (ICD-O-3), was used for topographical and morphological classifications. Multiple primary cancers with multi-organ primitiveness were selected from the database of the RTI by extracting patients with more than one diagnosis. SPCs had different histology or morphology from the particular cancer that was considered to be the index cancer case. Multicenter or multifocal cancers, or metastases, were excluded. The percentages of cancer by sex and topography, the average age of incidence, and a breakdown by age were computed. Results: Differences were observed between sexes in terms of incidence and site for SPCs. The most frequent SPC was skin cancer (20% of the SPCs observed). The associations among sites of multiple cancers are reported. Conclusion: There are many gaps in our knowledge of sex differences in cancer. The study of multiple primary cancers could bring more likely opportunities for evaluation of the cancer burden and trends that can be used to identify new research areas by population health programs, as well as for clinical researchers.
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Vukić, Tea, Nikolina Bašić-Jukić, Vesna Furić-Čunko, Ivana Jurić, and Željko Kaštelan. "Tumori nakon transplantacije bubrega." Medicina Fluminensis 56, no. 4 (December 1, 2020): 358–67. http://dx.doi.org/10.21860/medflum2020_245218.

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Završni stadij kronične bubrežne bolesti zahtijeva liječenje nadomještanjem bubrežne funkcije različitim metodama, od kojih je najbolja transplantacija bubrega, zbog značajno više stope preživljavanja i kvalitete života u usporedbi s dijalizom. U početcima transplantacijske medicine, kada su transplantacije izvođene samo u mlađih pacijenata, a preživljenje presatka bilo relativno kratko zbog visoke stope akutnih odbacivanja, zloćudni tumori predstavljali su manje važan problem. Vodeći uzrok gubitka presatka u vrijeme suvremene imunosupresije je smrt pacijenata s funkcionirajućim presatkom, a upravo su zloćudni tumori, nakon srčanožilnih bolesti i infekcija, na trećem mjestu uzročnika smrti u populaciji pacijenata s transplantacijom koja je sve starija i pod sve dužim kumulativnim djelovanjem imunosupresiva. Prema podatcima Registra za transplantaciju Australije i Novog Zelanda 10 % pacijenata razvije tumor nakon 10 godina, 25 % nakon 20 godina, a nakon 30 godina čak 40 % primatelja bubrega pod imunosupresivnom terapijom razvije tumor. U kohorti od 175 000 primatelja u Sjedinjenim Američkim Državama je identificirano 10 656 tumora, što je 2,1 puta više nego u općoj populaciji. Uočen je značajan porast rizika za više od 30 različitih primarnih tumora te snižena incidencija tumora dojke i prostate u odnosu na opću populaciju.
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Meel, Mukta, Nikita Choudhary, Mukesh Kumar, and Kusum Mathur. "Epidemiological Profiling and Trends of Primary Intracranial Tumors: A Hospital-Based Brain Tumor Registry from a Tertiary Care Center." Journal of Neurosciences in Rural Practice 12, no. 01 (January 2021): 145–52. http://dx.doi.org/10.1055/s-0040-1721622.

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Abstract Background and Objectives Hospital-based cancer registry is an essential tool for augmentation of the standard of care, administration motive, and resource for population-based cancer registries. Here, we presented hospital-based brain tumor registry (HBBTR) to outline a comprehensive epidemiological data, both clinical and histopathological, as well as trends of central nervous system tumors. In addition, we compare this data with national brain tumor data as well as an international brain tumor registry. Materials and Methods For the generation of this 7-year HBBTR data of all primary intracranial tumors operated, diagnosed, and registered at the Department of Pathology, Sawai ManSingh, between January 1, 2013 and December 31, 2019, was collected, analyzed, and compared with Tata Memorial Hospital, National Institute of Mental Health and Neurosciences, and Central Brain Tumor Registry of the United States. Results A total of 3,526 patients were of primary intracranial tumors. Out of which, male patients were 1,982 (56.2%), while 1,544 (43.8%) were female patients. Maximum proportion of tumors was in fifth decade. Overall, pediatric and adult patients constituted of 15.5 and 84.5% of the cases, respectively. Among all primary intracranial tumors, meningiomas (20%) were most common followed by glioblastoma multiformat (18%) and least common were germ cell tumors (0.1%) followed by pineal tumors (0.3%). In pediatric cohort astrocytic tumors (30.1%) are most common followed by embryonal tumors (20.8%), while in adults meningiomas (23.1%) were most common followed by glioblastomas (20.3%). Our registry showed similar trends of tumors with national data as compared with international data in median age of presentation. Conclusion This HBBTRs provide prevalence of primary intracranial tumors at a tertiary care center and could be a part of population-based registry.
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De Oliveira, Andrea Santos, Marcela Maria Nassar De Vasconcellos, Marcella de Brito Abath, Isabella Martins Barbosa da Silva Paes, and Emmanuelly Correia De Lemos. "Registros Hospitalares de Câncer em Pernambuco: da Gestão ao Registro." Revista Brasileira de Cancerologia 63, no. 1 (January 30, 2019): 21–28. http://dx.doi.org/10.32635/2176-9745.rbc.2017v63n1.152.

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Introdução: As neoplasias vêm ganhando destaque no perfil epidemiológico das doenças nas populações do mundo, inclusive no Brasil. Assim, a vigilância do câncer precisou adotar novas estratégias para se adequar à realidade. Uma delas, o Registro Hospitalar de Câncer (RHC), coleta dados de pacientes diagnosticados e/ou tratados para câncer, sendo importante para qualificar a assistência a eles prestada e para reconhecimento e disseminação de informações sobre morbimortalidade e fatores de risco para o câncer, visando à implementação de medidas para prevenção e controle. Objetivo: Descrever as estratégias utilizadas pela gestão estadual de Pernambuco para a qualificação do RHC e seus resultados. Métodos: Estudo transversal, descritivo, de abordagem mista. Para análise qualitativa, foram utilizados documentos da gestão estadual, de 2012 a 2015, relacionados aos RHC de Pernambuco. Para análise quantitativa, foram utilizadas algumas variáveis da ficha de tumor disponíveis ao público no Integrador RHC, do ano de 2012. Os resultados foram apresentados por meio de linha do tempo e tabela. Resultados: A análise documental revelou a adoção de várias estratégias para melhoria do RHC entre 2012 e 2015, foram elas: reuniões com as equipes das unidades hospitalares, implantação do projeto de diagnóstico e intervenção, capacitações e participações em eventos de âmbito nacional. O envio dos bancos de dados apresentou melhora no mesmo período. Quanto à incompletude das informações, apenas uma variável atingiu o patamar de qualidade desejado. Conclusão: As estratégias adotadas pela gestão estadual em conjunto com as equipes das unidades hospitalares parecem ter melhorado a qualidade dos RHC.
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Mercier, Kelly A., and Darragh M. Walsh. "The initiation, design, and establishment of the Desmoid Tumor Research Foundation Patient Registry and Natural History Study." Rare Tumors 11 (January 2019): 203636131988097. http://dx.doi.org/10.1177/2036361319880978.

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Desmoid tumors are locally invasive sarcoma, affecting 5–6 individuals out of 1,000,000 per year. The desmoid tumors have high rates of recurrence after resection and can lead to significant deterioration of the quality of life of patients. There is a need for a better understanding of the desmoid tumors’ patient experience from first symptoms through diagnosis, disease monitoring, and clinical treatment options. With the National Organization of Rare Disorders, the Desmoid Tumor Research Foundation Natural History Study was designed to be collected through the registry. This article describes the protocol for the Desmoid Tumor Research Foundation Natural History Study and some initial findings. The Desmoid Tumor Research Foundation Natural History Study Advisory Committee developed a series of questionnaires and longitudinal surveys, in addition to those from the National Organization of Rare Disorders for all of the rare diseases. These 13 surveys are designed to uncover initial symptoms, diagnosis process, disease monitoring, quality of life, treatments, as well as socioeconomic information. Since launching the Desmoid Tumor Research Foundation Registry and Natural History Study ( https://dtrf.iamrare.org ), more than 300 desmoid tumor patients have consented to the Desmoid Tumor Research Foundation Natural History Study and completed the Participant Profile. The majority of the respondents are between the ages of 21 and 50 years (76%), female (81.2%), White (91.5%), and live in the United States (47.1%). The majority of tumors are in the lower or upper extremity, (22.9%) followed closely by abdominal desmoid tumors (21.5%). Most are willing to donate specimens (89.9%) and participate in trials (97.2%). Ongoing efforts are addressing the demographic differences between the respondents and non-respondents and any selection bias based on access to the registry and study. The Desmoid Tumor Research Foundation Natural History Study is built on the largest desmoid tumors registry and has recruited more desmoid tumors participants since launching in September 2017. It will serve to fill desmoid tumors knowledge gaps and assist other researchers in their recruitment efforts for additional studies.
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Szövérfi, Zsolt, Áron Lazáry, and Péter Pál Varga. "Primary Spinal Tumor Registry in the National Centre for Spinal Disorders." Orvosi Hetilap 155, no. 19 (May 2014): 745–49. http://dx.doi.org/10.1556/oh.2014.29920.

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Primary spinal tumors are rare diseases. Primary spinal tumor registry would be useful to help decision making in this complex field of spine surgery. In this article the authors present the latest findings from the Primary Spinal Tumor Registry at the National Centre for Spinal Disorders, Hungary. The registry is based on a novel database management software, the REDCap electronic data capture system. It contains data of 323 patients treated surgically during an 18-year period. Among the 126 malignant tumors, the most frequent was chordoma (61 cases). In the case of benign tumors schwannoma showed the largest prevalence (45 cases). The authors conclude that due to the rarity of the disease and the complexity of the management, multicenter, prospective registries are required to provide high level of evidence. The structure of the Primary Spinal Tumor Registry in the National Centre for Spinal Disorders in Hungary is optimal for user-friendly, fast and secure data collection providing a prospective database for scientific researches and clinical follow-up. Orv. Hetil., 2014, 155(19), 745–749.
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Manasanch, Elisabet E., Jillian K. Smith, Andreea Bodnari, Jeannine McKinney, Catherine Gray, Theodore P. McDade, and Jennifer F. Tseng. "Tumor Registry Versus Physician Medical Record Review: A Direct Comparison of Patients With Pancreatic Neuroendocrine Tumors." Journal of Oncology Practice 7, no. 2 (March 2011): 111–16. http://dx.doi.org/10.1200/jop.2010.000097.

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Academic tumor registry analysis indicates many patients with pancreatic neuroendocrine tumors are not identified when compared with physician medical record review. Reasons include registry time lag and case-finding methodologies.
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Thorstenson, Andreas, Ulrika Harmenberg, Per Lindblad, Benny Holmström, Sven Lundstam, and Börje Ljungberg. "Cancer Characteristics and Current Treatments of Patients with Renal Cell Carcinoma in Sweden." BioMed Research International 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/456040.

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Methodology. Since the start in 2005 virtually all patients with newly diagnosed renal cell carcinoma (RCC) in Sweden are reported to the National Swedish Kidney Cancer Register (NSKCR). The register contains information on histopathology, nuclear grade, clinical stage, preoperative work-up, treatment, recurrence, and survival.Results. A total of 8556 patients with newly diagnosed RCC were registered in the NSKCR from 2005 to 2013 resulting in a coverage of 99% as compared to the Swedish Cancer Registry. The mean tumor size at detection decreased from 70 mm in 2005 to 64 mm in 2010. The proportion of patients who were incidentally detected increased. The proportion of patients with tumor stage T1a who underwent partial nephrectomy increased from 22% in 2005 to 56% in 2012. Similarly, the proportion of laparoscopically performed radical nephrectomies increased from 6% in 2005 to 17% in 2010. During the five years of follow-up 20% of the patients had a recurrence.Conclusion. Over the last decade there has been a trend of earlier detection and less advanced tumors at detection in patients with RCC. An increasing proportion of the patients undergo laparoscopic and nephron-sparing procedures.
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Kaplan, George W., William C. Cromie, Panayotis P. Kelalis, Igal Silber, and Edward S. Tank. "Prepubertal Yolk Sac Testicular Tumors - Report of the Testicular Tumor Registry." Journal of Urology 140, no. 5 Part 2 (November 1988): 1109–12. http://dx.doi.org/10.1016/s0022-5347(17)41974-4.

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Dissertations / Theses on the topic "Registro Tumori"

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SAVERIANO, FRANCESCO. "Incidenza dei tumori primitivi del Sistema Nervoso Centrale in una popolazione ospedalizzata nella provincia di Foggia nel quinquennio 2005-2009." Doctoral thesis, Università di Foggia, 2014. http://hdl.handle.net/11369/331739.

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ABSTRACT Background Studi epidemiologici, recenti e non, hanno ipotizzato un’eziologia multifattoriale (genetica, ambientale, immunitaria) nella genesi dei tumori cerebrali. A causa della relativa rarità dei tumori cerebrali, la maggior parte degli studi analitici sono di caso-controllo, viceversa sono molti i dati descrittivi raccolti nei vari registri esistenti. Scopo del lavoro Lo studio si è proposto lo scopo di valutare l’incidenza dei tumori primitivi del Sistema Nervoso Centrale nella popolazione ospedalizzata della provincia di Foggia, nel periodo dal 2005 al 2009. Inoltre, ha valutato la presenza di eventuali correlazioni esistenti con la distribuzione territoriale della popolazione (ad es. quelle rurali e quelle industrializzate), le fasce d’età, il sesso, la localizzazione anatomica della neoplasia ed il tipo istologico. I dati raccolti in questo studio forniranno la base metodologica per l’implementazione di un Registro Regionale della Puglia per i tumori primitivi del S.N.C. Materiali e Metodi La raccolta dei dati è stata effettuata nella Azienda Ospedaliero-Universitaria “Ospedali Riuniti di Foggia e nell’IRCCS “Casa Sollievo della Sofferenza” di San Giovanni Rotondo, unici nosocomi in cui sono presenti reparti di Neurologia e Neurochirurgia. Sono stati rilevati i dati dei pazienti ricoverati per diagnostica e/o trattamento nel periodo dal 2005 al 2009. I pazienti sono stati ricercati tramite le Schede di Dimissione Ospedaliera (SDO) secondo l’ICD9-CM. Sono stati individuati 531 pazienti con diagnosi di neoplasia cerebrale primitiva. In 373 pazienti si trattava di nuova diagnosi di neoplasia cerebrale primitiva. Per ogni paziente è stata compilata una scheda raccolta dati ed è stata eseguita un’analisi descrittiva dei dati raccolti. La definizione istologica e radiologica della neoplasia del sistema nervoso centrale è stata effettuata secondo l’ultima revisione della classificazione proposta dall’Organizzazione Mondiale della Sanità introdotta nel 2007. Risultati Il tasso di incidenza di tutte le neoplasie primitive del Sistema Nervoso Centrale totale è risultato di 10.9 nuovi casi ogni 100.000 abitanti residenti. Nel corso degli anni oggetto dello studio il trend dell’incidenza è risultato essere in diminuzione dal 2005 al 2008 per poi rimanere costante negli ultimi due anni dell’osservazione. Al netto dei meningiomi, invece, il tasso di incidenza è risultato essere di 6.47 nuovi casi ogni 100,000 abitanti residenti. Il picco dell’incidenza (per fasce d’età) al netto dei meningiomi è risultato 65-69 per il genere maschile e 70-74 per il genere femminile. I tumori cerebrali primitivi più frequenti sono, sia se si tiene conto dei referti neuro-radiologici sia di quelli istologici, quelli della serie astrocitaria, con i subordine i tumori della serie meningea. L’età media alla diagnosi delle neoplasie ovviamente dipende strettamente dal tipo istologico, risultando essere più elevata per meningiomi e, viceversa, minore per tumori quali l’astrocitoma pilocitico e il medulloblastoma. Riguardo infine l’incidenza ed il rischio cumulativo divisi per comune non sono emerse differenze rilevanti tra i vari comuni appartenenti alla provincia di Foggia. Conclusioni Quanto emerso dal nostro studio conferma l’eziologia multifattoriale delle neoplasie primitive del Sistema Nervoso Centrale. Per quanto riguarda, invece, i restanti dati raccolti nel nostro studio, in parte essi risultano sovrapponibili a quanto già emerso nel registro AIRTUM, in parte, invece, non vi sono, a tutt’oggi e in Italia, altri metri di paragone essendo, gli altri registri, non specificamente dedicati ai tumori del SNC ed in particolar modo alle forme primitive.
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Bordini, L. "LA RICERCA SISTEMATICA DEI TUMORI PROFESSIONALI: ATTIVAZIONE E PRIMI RISULTATI DEL REGISTRO TUMORI DEI SENI NASALI E PARANASALI DELLA LOMBARDIA." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/152896.

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We present the findings of the first years of activity of the Lombardy registry of sinonasal cancers (SNC), which was started at the end of 2007. The registry collects all potential cases of primary malignant epithelial neoplasm of the nasal cavity and accessory sinuses, verifies clinical records, and interviews the patients or their next-of-kin to investigate exposures to known SNC carcinogens. Case ascertainment is complete for the year 2008: we recorded 31 verified cases among men and 24 among women. The age-standardized regional incidence rates were 0.8 and 0.5  100,000 in men and women, respectively. For 87 cases diagnosed in 2008-2010 period we obtained an interview. In 34 cases (32 M and 2 F), we documented occupational exposure to wood dust (61.8%), leather dust (29.4%), bitumen fumes (5.9%), and hexavalent chromium compounds (2.9%). For these subjects compensation claims were undertaken. In 4 cases we found leisure-time exposures. In 49 cases (56.3%) no evidence of exposure to known SNC carcinogens was found.
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Santos, Marceli de Oliveira. "Indicadores de cobertura em registros de cancer : proposta metodologica para avaliação dos registros de cancer de base populacional." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313496.

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Orientador: Djalma de Carvalho Moreira Filho
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-14T09:34:37Z (GMT). No. of bitstreams: 1 Santos_MarcelideOliveira_D.pdf: 636134 bytes, checksum: 78b53a7902f3e2cfd099088e331c0646 (MD5) Previous issue date: 2009
Resumo: A informação sobre incidência de câncer, obtida através dos registros de câncer de base populacional - RCBP é um componente essencial de qualquer estratégia de controle de câncer. Nos últimos vinte anos o papel dos registros de câncer tem se ampliado, incorporando o planejamento e avaliação das atividades de controle de câncer. Neste cenário, torna-se de fundamental importância a qualidade das informações fornecidas pelos registros. Uma breve revisão das metodologias para realizar o controle de qualidade dos dados nos registros de câncer, das mais tradicionalmente utilizadas às alternativas propostas torna claro que tais processos não são de fácil aplicação. O RCBP de Porto Alegre foi escolhido para verificar a aplicabilidade desta metodologia à realidade dos registros de câncer brasileiros. O Método de Fluxos apresenta-se neste contexto como adaptável a registros de câncer de diferentes padrões, de rápida execução e sem custos financeiros adicionais. O método proposto permite que o registro de câncer estabeleça uma rotina de vigilância de cobertura, segundo variáveis, tais como, localização primária, idade, sexo e área geográfica.
Abstract: Population-based cancer registries are essential to public health and research. The cancer registries provide information on the surveillance of cancer incidence and survival. At the last 20 years, because of the emerging importance of cancer as a health problem, the cancer registries play a important role to evaluate and to frame public health policy to cancer control. A high-quality cancer registration is fundamental to monitoring cancer burden and identifies patterns and trends in various population groups, in different geographic areas, and over time. Cancer registries try to achieve maximum completeness in case-findings procedures in order to ensure that comparative studies are not distorted by variations on efficacy of registry procedures. A brief review about available methods used to estimate completeness of cancer registrations shows that these methodologies are not easy to use, especially in developing countries. The PBCR Porto Alegre was chosen to verify if the method could be applied to Brazilian cancer registries reality. In this context the Flow Method claims to be adaptable to cancer registries with different patterns of registration and can be executed rapidly and inexpensively. The proposed method allows to a cancer registry to provide a routine surveillance of completeness by variables such as tumor site, age, sex and geographic area.
Doutorado
Saude Coletiva
Doutor em Saude Coletiva
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Bin, Ishaq Saeed A. "Epidemiology of cancer as a tool to develop a population based cancer registry in the United Arab Emirates." Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/6197/.

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The purpose of this study was to assess the possibility of developing a population based cancer registry in the United Arab Emirates. As this was retrospective and explorative in nature, the study was performed in two stages, the initial stage where the researcher examined critically routinely collected data that is needed to support a cancer registry as well as assessed data on cancer that were obtained from Al Mafraq Hospital records. The final stage took place in Al Ain Medical District where detailed study of the existing practice with respect to cancer registration were undertaken in respond to a request form Ministry of Health, data on cancer were obtained from health care services and cancer registry records. Other information was obtained from key officials and health professionals in the district using qualitative methods. The initial stage showed that this was the first study of this kind in the United Arab Emirates and that cancer data production and recording is a complex intervention, where health and health related professionals and patients are involved. It also revealed that the key professionals were supportive to the study and showed positive attitude. The initial study indicated that there was deficiency in the data collected routinely as well as there was no cancer registry in Al-Mafraq Hospital. Furthermore, the data collected from medical record witnessed deficiency in their completeness and quality. Lack of education and training related to cancer data handling were observed during the fieldwork. The assessment of the population data sources indicated that there was no single data source that might provide a comprehensive and accurate data regarding Al Ain population. This condition was mainly created due to unique demographic pattern of a highly mobile population dominated by expatriates. The final stage showed that health facilities in Al Ain Medical District are capable of producing cancer data especially clinical data. However deficiencies in item definition, complete recording and storing of data by health professionals within the health facilities were identified.
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GALLI, GIULIA. "THE EUDRACT 2017-004494-13 TRIAL ON THYMIC EPITHELIAL TUMORS: THE PARADIGM OF A COMPREHENSIVE STUDY FOR A RARE DISEASE." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/931345.

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Lyth, Johan. "Clinical-epidemiological studies on cutaneous malignant melanoma : A register approach." Doctoral thesis, Linköpings universitet, Avdelningen för kliniska vetenskaper, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-113145.

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The incidence of cutaneous malignant melanoma (CMM) is steadily increasing. Most of the patients have thin CMM with a good prognosis and a 5-year survival of about 90%. The prognosis is highly related to tumour thickness and clinical stage at diagnosis. Effective systemic treatment for patients with metastatic disease has only recently been available. This thesis aims to increase knowledge of trends in tumour thickness, prognostic factors, socioeconomic differences and medical costs in patients with CMM. The population-based Swedish melanoma register is the main source of data in all papers in the thesis. Papers I-III include patients from all of Sweden while paper IV is delimited to the County of Östergötland. Cox regression and logistic regression are the main multivariable methods used. Paper IV is focused on stage-specific costs of CMM by comparing direct healthcare costs to a general population. For men, there has been a shift over time towards thinner tumours at diagnosis accompanied by an improved survival. Women are still diagnosed with considerably thinner tumours and they experience a better survival than men. Tumour ulceration, tumour thickness and Clark’s level of invasion all showed significant independent long-term prognostic information in T1 CMMs. By combining these factors, three distinct prognostic subgroups were identified. Lower level of education was associated with reduced CMM-specific survival, which may at least partially be attributed to a more advanced stage at diagnosis. The direct healthcare costs for CMM patients were significantly higher than for the general population, independent of clinical stage. CMM patients diagnosed in clinical stage III-IV were associated with particularly high costs. Even though the survival among Swedish patients with CMM is among the highest in the world and still seems to improve, the results of this thesis emphasise the need of improved early detection strategies. This may be of particular concern in men, older women, and groups with a low level of education. The results also imply that the costs for the management of CMM patients may be reduced if early detection efforts are successful and lead to a more favourable stage distribution. The finding of a better risk stratification of thin CMMs may help to improve the management of this large patient group.
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Desing, Lena Katrin [Verfasser], Ines [Akademischer Betreuer] Brecht, and Ines [Gutachter] Brecht. "Detaillierte Datenerhebung des Registers für Seltene Tumoren (STEP) im Analysezeitraum November 2012 bis November 2015 / Lena Katrin Desing ; Gutachter: Ines Brecht ; Betreuer: Ines Brecht." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2021. http://d-nb.info/1232496944/34.

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Lyth, Johan, J. Hansson, C. Ingvar, E. Mansson-Brahme, P. Naredi, U. Stierner, G. Wagenius, and C. Lindholm. "Prognostic subclassifications of T1 cutaneous melanomas based on ulceration, tumour thickness and Clark’s level of invasion : results of a population-based study from the Swedish Melanoma Register." Linköpings universitet, Onkologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-92611.

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Background  Survival and prognostic factors for thin melanomas have been studied relatively little in population-based settings. This patient group accounts for the majority of melanomas diagnosed in western countries today, and better prognostic information is needed. Objectives  The aim of this study was to use established prognostic factors such as ulceration, tumour thickness and Clark’s level of invasion for risk stratification of T1 cutaneous melanoma. Methods  From 1990 to 2008, the Swedish Melanoma Register included 97% of all melanomas diagnosed in Sweden. Altogether, 13 026 patients with T1 melanomas in clinical stage I were used for estimating melanoma-specific 10- and 15-year mortality rates. The Cox regression model was used for further survival analysis on 11 165 patients with complete data. Results  Ulceration, tumour thickness and Clark’s level of invasion all showed significant, independent, long-term prognostic information. By combining these factors the patients could be subdivided into three risk groups: a low-risk group (67·9% of T1 cases) with a 10-year melanoma-specific mortality rate of 1·5% (1·2–1·9%); an intermediate-risk group (28·6% of T1 cases) with a 10-year mortality rate of 6·1% (5·0–7·3%); and a high-risk group (3·5% of T1 cases) with a 10-year mortality rate of 15·6% (11·2–21·4%). The high- and intermediate-risk groups accounted for 66% of melanoma deaths within T1. Conclusions  Using a population-based melanoma register, and combining ulceration, tumour thickness and Clark’s level of invasion, three distinct prognostic subgroups were identified.

Funding Agencies|regional cancer centre Southeast in Linkoping||

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Hamann, Philip. "An investigation into the predictors and frequency of sustained remission in patients with rheumatoid arthritis undergoing treatment with anti-tumour necrosis factor therapy using the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis." Thesis, University of Bath, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760961.

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Background. Response to anti-tumour necrosis factor (anti-TNF) therapy in patients with rheumatoid arthritis (RA) varies between patients. Incidence of sustained remission in the UK is not known, and factors contributing to its achievement are poorly understood. Prior knowledge of response would enable better targeting of anti-TNF therapy, leading to better outcomes and reduced morbidity. Aims. This thesis aims to identify incidence of sustained remission and low disease activity (LDA) in patients with rheumatoid arthritis (RA) taking anti-TNF therapy. Clinical and demographic factors associated with sustained remission and LDA were identified. Methods. I undertook a systematic literature review of the incidence of, and factors associated with, sustained remission in patients with RA taking anti-TNF therapy. Results informed a subsequent analysis of data extracted from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR-RA). I used two approaches to examine sustained remission and LDA. Firstly, pre-defined DAS28 thresholds were used to identify individuals in sustained remission and LDA. Secondly, a data-driven approach used latent class mixed modelling (LCMM) to identify independent trajectories of response within the data. Results. Sustained remission and LDA occurred infrequently in the literature review (range 4.2 – 38.1% sustained remission) and was uncommon in the BSRBR-RA (14.9% and 26.3% respectively), but had improved significantly over time. Significant associations were identified between the candidate variables and sustained remission and LDA, both using pre-defined thresholds and LCMM analyses. LCMM analyses identified response at six months to be a good indicator of long-term outcomes. Conclusions. Sustained remission and LDA remains uncommon, although outcomes are improving. Clinical and demographic features are associated with achieving these outcomes, suggesting it may be possible to use phenotypic features to guide therapy. Additionally, the clear response trajectories identified at six months, suggest it may be possible to identify non-responders to anti-TNF therapy earlier than six months.
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Kroll, Mary Eileen. "Time trends in childhood cancer : Britain 1966-2005." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:8be887be-36e7-4b77-a7af-5887f3a1df8c.

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Increasing time trends in the recorded incidence of childhood cancer have been reported in many different settings. The extent to which these trends reflect real changes in incidence, rather than improvements in methods for diagnosis and registration, is controversial. Using data from the National Registry of Childhood Tumours (NRCT), this thesis investigates time trends in cancer diagnosed under age 15 in residents of Britain during 1966-2005 (54650 cases), and considers potential sources of artefact in detail. Several different methods are used to estimate completeness of NRCT registration. The history of methods for diagnosis and registration of childhood cancers in Britain is described, and predictions are made for effects on recorded incidence. For each of the 12 main diagnostic groups, Poisson regression is used to fit continuous time trends and ‘step’ models to the annual age-sex-standardised rates by year of birth and year of diagnosis. Age-specific rates by period, and quinquennial standardised rates for diagnostic subgroups, are shown graphically. For three broad groups (leukaemia, CNS tumours and other cancer), geographical variation is compared by period of diagnosis. The results of these analyses are discussed in relation to the predicted artefacts. The evidence for a positive association between affluence and recorded incidence of childhood leukaemia is briefly reviewed. A special form of diagnostic artefact, the ‘fatal infection’ hypothesis, is proposed as an explanation of both this association and the leukaemia time trend. This hypothesis is examined in a novel test based on clinical data. The recorded incidence of childhood cancer in Britain increased in each of 12 diagnostic groups during 1966-2005 (from 0.5% per year for bone cancer to 2.5% for hepatic cancer, with 0.7% for leukaemia). Evidence presented here suggests that these increases are probably artefacts of diagnosis and registration. The potential implications for epidemiological studies of childhood cancer should be considered.
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Books on the topic "Registro Tumori"

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Registry, Connecticut Tumor. Connecticut Tumor Registry. Hartford, CT (410 Capitol Ave., Hartford 06134-0308): State of Connecticut, Dept. of Public Health, Connecticut Tumor Registry, 1999.

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Registry, Montana Central Tumor. The Montana Central Tumor Registry newsletter. Helena, Mont: Montana Central Tumor Registry, 2008.

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Laura, Eduardo Alberto. Registro regional de tumores del sur de la provincia de Buenos Aires, resultados entre 1989 y 1992: Hacia un análisis racional para el control del cancer. 2nd ed. [Bahía Blanca]: LALCEC Filial Bahía Blanca, Asociación Argentina de Educación y Prevención del Cancer, 1994.

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Ontario Cancer Treatment and Research Foundation. Ontario Cancer Registry, ed. Twenty years of cancer incidence: 1964-1983 Ontario Cancer Registry. Toronto: OCTRF, 1987.

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Ch, Witting, ed. Möglichkeiten für den Aufbau eines berufsbezogenen Tumor-Registers: Theoretische Ansätze und erste Erfahrungen. Dortmund: Bundesanstalt für Arbeitsschutz, 1985.

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Ballew, Carol. Cancer among American Indian residents of Montana 2002-2006: A special report of the Montana Central Tumor Registry. Helena, Mont: Montana Dept. of Public Health and Human Services, 2008.

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Ballew, Carol. Cancer among American Indian residents of Montana 2002-2006: A special report of the Montana Central Tumor Registry. Helena, Mont: Montana Dept. of Public Health and Human Services, 2008.

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Cancer Registry. Springer, 2012.

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Pedersen, E., and E. Grundmann. Cancer Registry. Springer, 2012.

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Tijssen, C. C. Familial Brain Tumours: A Commented Register. Springer, 2011.

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Book chapters on the topic "Registro Tumori"

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Taylor, Sarah H. "History of MD Anderson’s Tumor Registry." In 60 Years of Survival Outcomes at The University of Texas MD Anderson Cancer Center, 5–11. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5197-6_2.

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Shibui, Soichiro, and Kazuhiro Nomura. "Statistical Analysis of Pineal Tumors Based on the Data of Brain Tumor Registry of Japan." In Progress in Neurological Surgery, 1–11. Basel: KARGER, 2009. http://dx.doi.org/10.1159/000210049.

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Harms, D. "Soft Tissue Sarcomas in the Kiel Pediatric Tumor Registry." In Current Topics in Pathology, 31–45. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-77289-4_3.

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Ruzevick, Jacob, Eric T. Wong, and Maciej M. Mrugala. "Tumor Treating Fields in Clinical Practice with Emphasis on PRiDe Registry." In Alternating Electric Fields Therapy in Oncology, 79–92. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30576-9_7.

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Grüger, Joscha, Tobias Geyer, Martin Kuhn, StephanA Braun, and Ralph Bergmann. "Verifying Guideline Compliance in Clinical Treatment Using Multi-perspective Conformance Checking: A Case Study." In Lecture Notes in Business Information Processing, 301–13. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-98581-3_22.

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AbstractClinical guidelines support physicians in the evidence-based treatment of patients. The technical verification of guideline compliance is not trivial, since guideline knowledge is usually represented textually and none of the approaches to computer-interpretable guideline representation has yet been able to establish itself. Due to the procedural nature of treatment sequences, this case study examines the applicability of a guideline process model to real hospital data for verification of guideline compliance. For this purpose, the limitations and challenges in the transformation of clinical data into an event log and in the application of conformance checking to align the data with the guideline reference model are investigated. As a data set, we use treatment data of skin tumor patients from a cancer registry enriched by hospital information system data. The results show the difficulty of applying process mining to medically complex and heterogeneous data and the need for complex preprocessing. The variability of clinical processes makes the application of global conformance checking algorithms challenging. In addition, the work shows the semantic weakness of the alignments and the need for new semantically sensitive approaches.
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Birch, Jillian M., and Valerie Blair. "The Epidemiology of Leukemia: Results from the Manchester Children’s Tumour Registry." In Childhood Leukemia: Present Problems and Future Prospects, 97–106. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3898-1_10.

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Qureshi, S., and R. A. Ettlin. "Tumor Registry Data Base: Systematized Nomenclature of Preneoplastic and Neoplastic Lesions in Rat Gonads." In Archives of Toxicology, 55–57. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-74936-0_10.

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Hörsch, Dieter, Samer Ezziddin, Alexander Haug, Klaus Friedrich Gratz, Simone Dunkelmann, Bernd Joachim Krause, Carl Schümichen, et al. "Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors in Germany: First Results of a Multi-institutional Cancer Registry." In Recent Results in Cancer Research, 457–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27994-2_25.

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Maki, Hussein AwadElkarim Hussein. "General Oncology Care in Sudan." In Cancer in the Arab World, 251–64. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7945-2_16.

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AbstractThe Sudanese healthcare system has two main branches to solve the country’s health problems, preventive medicine and therapeutic medicine. In other words, it mainly works with communicable and non-communicable diseases and the services are divided into primary level (for the primary health centers), secondary level (general hospitals), and tertiary level (specialized centers such as oncology and neurosurgery). However, the main factors that are drawbacks to the healthcare system are overall economic instability, low health expenditure, and civil wars. Data about cancer in Sudan is scarce. There is a lack of prospective whole country studies about cancer in Sudan. The instability of the population, inadequate trained personnel, and the inefficient cancer registry system contributed to the lack of accurate figures about the true incidence of cancer in Sudan. Therefore, the frequency ratios of tumors are mostly represented in different publications. Cancer in Sudanese patients is usually present lately or in advanced stages and many cases are reported at younger ages. Cancer treatment centers in Sudan are few with inadequate resources for the variety of treatment methods. While huge efforts are being made to improve cancer medical care in the country, there are still many obstacles that need to be solved to ensure that cancer patients have a high standard of services in both public and private sectors. There are limited early detection and screening programs, especially in rural areas. More diagnostic and treatment centers are now being established in many cities in Sudan. This chapter addresses the general view of the cancer situation in Sudan, reviewing the different aspects of the cancer burden and different associated conditions related to oncology.
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Morawietz, G., and S. Rittinghausen. "Variations in Prevalence of Endocrine Tumors Among Different Colonies of Rats? A Retrospective Study in the Hannover Registry Data Base." In Archives of Toxicology, 205–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-77260-3_28.

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Conference papers on the topic "Registro Tumori"

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Lima, Amanda Cristina Barreiros de Souza, and Evelyn de Souza Palmeira. "Leiomioma cotiledonoide do útero: um relato de caso." In 44° Congresso da SGORJ - XXIII Trocando Ideias. Zeppelini Editorial e Comunicação, 2020. http://dx.doi.org/10.5327/jbg-0368-1416-2020130224.

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Objetivo: Relatar um caso de leiomioma cotiledonoide, que é um tumor de fibras musculares lisas do útero e tem esse nome pela sua semelhança com a placenta. É um tumor raro, que pode facilmente ser confundido com patologia maligna, pela sua aparência. Métodos: Revisão de prontuário, revisão de laudo histopatológico, registro fotográfico da peça cirúrgica e revisão da literatura. Resultados: G.N.X., 36 anos, com história de aumento progressivo do volume abdominal, há alguns meses, sem queixa de dor pélvica, alteração do ciclo menstrual ou perda ponderal, foi encaminhada para o Ambulatório de Ginecologia do Hospital Universitário Clementino Fraga Filho, da Universidade Federal do Rio de Janeiro (UFRJ), para investigação do caso. Não apresentava patologias prévias. Sua paridade era gesta III para III (três partos vaginais). Seus ciclos menstruais eram regulares e tinha vida sexual ativa, sem uso de método contraceptivo. Ao exame do abdômen, era palpada tumoração heterogênea e de consistência firme, ocupando hipogástrio, mesogástrio, fossa ilíaca direita e flanco direito. O exame da vulva e o especular eram normais. Ao toque bimanual, o colo era irregular e havia presença de tumoração pélvica, de consistência endurecida, pouco móvel e indolor, ocupando todo o hipogástrio, parte do mesogástrio e estendendo-se para fossa ilíaca direita e parte do flanco direito. Já havia realizado duas ultrassonografias. A primeira delas visualizou imagem sugestiva de Mola Hidatiforme, enquanto a segunda sugeriu tumoração de provável origem anexial. Foi então solicitada ressonância magnética de pelve, com visualização de formação nodular ovalada, medindo 19,0×15,7×10,6 cm, indicativo de leiomioma subseroso pediculado, com degeneração cística/mixoide. Dosagem de marcadores tumorais: CA 19,9‒4,3 U/mL; CA 125‒567 U/mL; antígeno carcinoembrionário (CEA) 1,05 ng/mL. Indicada abordagem cirúrgica. Realizada laparotomia exploradora, com observação de tumor de aproximadamente 15 cm, com base séssil em região cornual esquerda do útero, friável, de aspecto irregular e com aparência de placenta, com parte aderida em alça intestinal. Realizadas ressecção do tumor, histerectomia total, salpingectomia bilateral e anexectomia à esquerda, pois esse ovário estava aderido à alça intestinal. O exame histopatológico da peça cirúrgica revelou leiomioma cotiledonoide dissecante. Conclusão: O leiomioma cotiledonoide é uma rara variante do leiomioma uterino, que pode ser confundido com outras patologias, tais como tumor ovariano e sarcoma uterino. Por isso, é importante que o ginecologista e o patologista saibam da existência dessa variante para assim evitar um tratamento excessivo.
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Call, Jerry W., P. D. Josephy, Jens Eickhoff, Roberto Pazmino, Magda Sarnas, and Norman J. Scherzer. "Abstract 1835: Life Raft Group registry: An observational registry of gastrointestinal stromal tumor (GIST) patients." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1835.

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Albuquerque, Lucas Vieira de, João Victor Queiroz Moraes, Lucas Andrade Brito, Samuel Sales Bezerra, and Diego Menezes De Oliveira. "PERFIL EPIDEMIOLÓGICO DOS PACIENTES INTERNADOS POR CÂNCER DE PRÓSTATA NA REGIÃO NORDESTE DO BRASIL NO PERÍODO DE 2011 A 2020." In I Congresso Nacional Multidisciplinar de Oncologia On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1563.

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Introdução: Câncer de próstata é a multiplicação descontrolada das células da próstata, originando um tumor maligno. Trata-se do segundo tipo de neoplasia mais frequente nos homens. Alguns desses tumores podem crescer rapidamente, espalhando-se para outros órgãos e podendo levar a óbito. Objetivos: Identificar o perfil epidemiológico dos pacientes internados por câncer de próstata na região Nordeste do Brasil, no período de 2011 a 2020. Materiais e Métodos: Trata-se de um estudo ecológico cujos dados foram coletados no Sistema de Informação Hospitalar (SIH/DATASUS), em morbidade hospitalar por local de internação, filtrados por divisão região, ano processamento, faixa etária, lista Morb CID-10 (neoplasia maligna de próstata), e analisados por Excel. Resultados: No período analisado, ocorreram 66.301 internações por câncer de próstata na região Nordeste (média anual 6.630,1±1.207,4). Em 2011 registrou-se a menor quantidade de internações, 4.577, em 2019, a maior quantidade, 8.182. Houve crescimento de 2011 até 2019, seguido de decréscimo de 13,37% em 2020 (N=7.088), em relação ao ano anterior. O estado com maior número de internações foi a Bahia (36,8%, N=24.414), enquanto Sergipe (1,89%, F=1.254) registrou o menor número. Na distribuição por raça/cor, a população parda foi a mais acometida (62.75%, N=41.605), e a indígena (0,0001%, N= 9) a menos afetada. A faixa etária mais acometida foi de 60 a 69 anos (37,62%, N=24.943) e a menos afetada foi de 10 a 19 anos (0.0006%, N=44). Conclusão: As internações por câncer de próstata no Nordeste brasileiro ocorrem, majoritariamente, na população parda, na faixa etária de 60 a 69 anos, residentes na Bahia. Dessa forma, a identificação dos grupos mais vulneráveis possibilita o direcionamento de ações e projetos para prevenção, diagnóstico e tratamento.
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Gollnick, Sandra, and Kristen Anton. "Development of a registry for patients treated with photodynamic therapy (Conference Presentation)." In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVII, edited by David H. Kessel and Tayyaba Hasan. SPIE, 2018. http://dx.doi.org/10.1117/12.2297194.

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Elsayed, Omar M., Samar M. Ismail, and Mohamed A. Abd El Ghany. "Register Transfer Level Model For CNN Tumor Detection on FPGA." In 2021 International Conference on Microelectronics (ICM). IEEE, 2021. http://dx.doi.org/10.1109/icm52667.2021.9664940.

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Colby, Samantha, Jaes Jones, Ghaith Habboub, Alex Witek, Shahed Tish, Josephine Volovetz, Paramita Das, et al. "Esthesioneuroblastoma: Descriptive Epidemiology from the Central Brain Tumor Registry of the United States." In 29th Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1679801.

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Almeida, Raissa Janine de, Arthur Felipe Decker, Carolina Terra de Moraes Luizaga, and Cristiane Murta Nascimento. "BREAST CANCER IN WOMEN: CHARACTERIZATION OF CASES INCLUDED IN THE HOSPITAL-BASED CANCER REGISTRY OF THE STATE OF SÃO PAULO AND FACTORS ASSOCIATED WITH ADVANCED STAGES." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1030.

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Introduction: Breast cancer is a public health problem worldwide, being the most common malignancy in the female population. It is a potentially curable disease with an early diagnosis. The advanced stage at the time of diagnosis is associated with increased morbidity and low survival for the patients. Objectives: To describe the sociodemographic, clinical, and anatomopathological characteristics of breast cancer cases in women included in the hospital-based cancer registry (RHC) of Fundação Oncocentro de São Paulo (FOSP), and to investigate factors associated with the clinical stage at diagnosis. Methods: The study design was a case series. The sample consisted of women with breast cancer diagnosed between 2000 and 2014 and included in the RHC-FOSP. The outcome variable was a clinical-stage (stage 0–II versus III–IV). The explanatory variables were age at diagnosis and educational level. This study was approved by the Human Research Ethics Committee of the Botucatu Medical School, São Paulo State University, Brazil. Results: The study included 84,987 women with in situ and invasive breast cancer diagnosed between 2000 and 2014. The average age of women at diagnosis was 56.7 years (95%CI 56.6–56.8 years). Sixty-five percent of cases completed elementary school or less and the most frequent histological type was ductal carcinoma (77.2%). During the study period, there was a slight decrease in the proportion of tumors in more advanced stages, from 39.8% in 2000 to 32.6% in 2014. There was a statistically significant association between age at diagnosis and educational level with the women’s grouped clinical stage. Women of older age and those with a higher education level had reduced odds ratios of having tumors in more advanced stages at the time of diagnosis. Conclusions: These findings may contribute to the development of policies for the identification of breast tumors at earlier stages.
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Sköld, C., T. Bjørge, A. Ekbom, A. Engeland, M. Gissler, T. Grotmol, L. Madanat-Harjuoja, et al. "P149 Pregnancy-related risk factors for sex cord-stromal tumors and germ cell tumors in parous women: a registry-based study." In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.210.

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Guerrero-Zotano, Angel, Carlos Jara, Sara López-Tarruella, César A. Rodríguez, Encarna Adrover, Catalina Falo, Purificación Martínez, et al. "Abstract PS5-22: Mutational profile from circulating tumor DNA in triple negative breast cancer: Results from the prospective registry of unresectable locally advanced or metastatic breast cancer GEICAM/2014-03 (RegistEM)." In Abstracts: 2020 San Antonio Breast Cancer Virtual Symposium; December 8-11, 2020; San Antonio, Texas. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.sabcs20-ps5-22.

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Wu, Hui-Chen, Hanina Hibshoosh, Regina Santella, and Mary Beth Terry. "Abstract 2555: Promoter DNA methylation patterns in breast tumor and matched adjacent non-tumor tissues in the breast cancer family registry." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2555.

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Reports on the topic "Registro Tumori"

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Leonard, Talayna, Robert Lemme, Cati Kral, Briana Santiago, Chris Elberts, Stephanie Dewald, Patrick McGonagill, et al. High-Percentage of Early Resectable Pancreatic Ductal Adenocarcinoma is Unidentified on Abdominal CT Obtained for Unrelated Diagnosis. Science Repository, December 2021. http://dx.doi.org/10.31487/j.aco.2021.02.03.

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Objective: Pancreatic ductal adenocarcinoma (PDAC) has the best survival when detected early with 5-year survival near 40% for small, resectable PDAC. We evaluate the undiagnosed PDAC imaging features on routine CT and their impact on resectability. Methods: 76 of the screened 134 CTs from 1/1/2012 to 12/31/2018 using our tumor registry were obtained prior to PDAC diagnosis for other indications at least one month before presentation. Each cross-sectional study was reviewed for features of early PDAC: pancreatic mass, pancreatic ductal dilatation, perivascular/peripancreatic soft-tissue infiltration, omental lesions/ascites, and lymphadenopathy. When such features were detectible by the reviewing radiologists, the original CT readings were classified as concordant/discrepant. Descriptive statistics are reported for discrepant reads, tumor resectability, and tumor size. Results: Of the 76 cases from 46 unique subjects (30 male/16 female), 25 CTs (33%) had undetected PDAC imaging features: masses (15/19 unreported), ductal dilatation (16/20 unreported), and peripancreatic/perivascular soft-tissue infiltration (20/36 unreported). 63% of early PDAC features were not identified initially. One year before clinical diagnosis, 75-80% of the PDAC cases were resectable; at < 6 months before clinical diagnosis, only 29% were resectable. Conclusion: Improving early detection of key PDAC features on routine CT examinations can potentially improve patient outcomes.
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Blanken, Annelies, Bafrin Abdulmajid, Eva van Geel, Joost Daams, Martin van der Esch, and Michael Nurmohamed. Effect of tumor necrosis factor inhibiting treatment on arterial stiffness and arterial wall thickness in rheumatoid arthritis patients: protocol for a systematic review and planned meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2022. http://dx.doi.org/10.37766/inplasy2022.1.0131.

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Review question / Objective: The aim of this systematic review is to evaluate the effect of TNF inhibiting treatment on arterial stiffness (as measured with pulse wave velocity and augmentation index) and arterial wall thickness (as measured with carotid intima media thickness) in rheumatoid arthritis patients. Condition being studied: Rheumatoid arthritis is a chronic autoimmune disorder, which affects approximately 1% of the population worldwide. Information sources: The following electronic databases will be searched for potentially eligible studies: EMBASE, MEDLINE, ClinicalTrials.gov and WHO International Clinical Trials Registry Platform. For the studies identified as eligible for inclusion, similarity tracking will be used to identify more potentially relevant articles with the ‘related article’ feature in PubMed. In addition, a citation search will be performed for included studies to identify articles that have cited them. Reference lists of the included studies and previous reviews on the subject will be searched for potentially relevant studies. ResearchGate profiles of top authors on the subject will be investigated to identify potentially relevant data points. For ongoing or finished studies that are potentially eligible, but without a publication, study authors will be contacted for information. When additional information is needed, study authors will be contacted as well.
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Shumway, Dean A., Kimberly S. Corbin, Magdoleen H. Farah, Kelly E. Viola, Tarek Nayfeh, Samer Saadi, Vishal Shah, et al. Partial Breast Irradiation for Breast Cancer. Agency for Healthcare Research and Quality (AHRQ), January 2023. http://dx.doi.org/10.23970/ahrqepccer259.

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Objectives. To evaluate the comparative effectiveness and harms of partial breast irradiation (PBI) compared with whole breast irradiation (WBI) for early-stage breast cancer, and how differences in effectiveness and harms may be influenced by patient, tumor, and treatment factors, including treatment modality, target volume, dose, and fractionation. We also evaluated the relative financial toxicity of PBI versus WBI. Data sources. MEDLINE®, Embase®, Cochrane Central Registrar of Controlled Trials, Cochrane Database of Systematic Reviews, Scopus, and various grey literature sources from database inception to June 30, 2022. Review methods. We included randomized clinical trials (RCTs) and observational studies that enrolled adult women with early-stage breast cancer who received one of six PBI modalities: multi-catheter interstitial brachytherapy, single-entry catheter brachytherapy (also known as intracavitary brachytherapy), 3-dimensional conformal external beam radiation therapy (3DCRT), intensity-modulated radiation therapy (IMRT), proton radiation therapy, intraoperative radiotherapy (IORT). Pairs of independent reviewers screened and appraised studies. Results. Twenty-three original studies with 17,510 patients evaluated the comparative effectiveness of PBI, including 14 RCTs, 6 comparative observational studies, and 3 single-arm observational studies. PBI was not significantly different from WBI in terms of ipsilateral breast recurrence (IBR), overall survival, or cancer-free survival at 5 and 10 years (high strength of evidence [SOE]). Evidence for cosmetic outcomes was insufficient. Results were generally consistent when PBI modalities were compared with WBI, whether compared individually or combined. These PBI approaches included 3DCRT, IMRT, and multi-catheter interstitial brachytherapy. Compared with WBI, 3DCRT showed no difference in IBR, overall survival, or cancer-free survival at 5 and 10 years (moderate to high SOE); IMRT showed no difference in IBR or overall survival at 5 and 10 years (low SOE); multi-catheter interstitial brachytherapy showed no difference in IBR, overall survival, or cancer-free survival at 5 years (low SOE). Compared with WBI, IORT was associated with a higher IBR rate at 5, 10, and over 10 years (high SOE), with no difference in overall survival, cancer-free survival, or mastectomy-free survival (low to high SOE). There were significantly fewer acute adverse events (AEs) with PBI compared with WBI, with no apparent difference in late AEs (moderate SOE). Data about quality of life were limited. Head-to-head comparisons between the different PBI modalities showed insufficient evidence to estimate an effect on main outcomes. There were no significant differences in IBR or other outcomes according to patient, tumor, and treatment characteristics; however, data for subgroups were insufficient to draw conclusions. Eight studies addressed concepts closely related to financial toxicity. Compared with conventionally fractionated WBI, accelerated PBI was associated with lower transportation costs and days away from work. PBI was also associated with less subjective financial difficulty at various time points after radiotherapy. Conclusions. Clinical trials that compared PBI with WBI demonstrate no significant difference in the risk of IBR. PBI is associated with fewer acute AEs and may be associated with less financial toxicity. The current evidence supports the use of PBI in appropriately selected patients with early-stage breast cancer. Further investigation is needed to evaluate the outcomes of PBI in patients with various clinical and tumor characteristics, and to define optimal radiation treatment dose and technique for PBI.
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