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Journal articles on the topic 'Regenerative medicine (incl. stem cells)'

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Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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1

Sykova, Eva, and Serhiy Forostyak. "Stem Cells in Regenerative Medicine." LASER THERAPY 22, no. 2 (2013): 87–92. http://dx.doi.org/10.5978/islsm.13-re-01.

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2

Casado-Díaz, Antonio. "Stem Cells in Regenerative Medicine." Journal of Clinical Medicine 11, no. 18 (September 16, 2022): 5460. http://dx.doi.org/10.3390/jcm11185460.

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3

Rao, Mahendra. "Stem cells and regenerative medicine." Stem Cell Research & Therapy 3, no. 4 (2012): 27. http://dx.doi.org/10.1186/scrt118.

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4

HIRAI, Hisamaru. "Stem Cells and Regenerative Medicine." Human Cell 15, no. 4 (November 2002): 190–98. http://dx.doi.org/10.1111/j.1749-0774.2002.tb00115.x.

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5

BOHILTEA, Roxana Elena, Erick George NESTIANU, Vlad DIMA, Bianca Margareta MIHAI, Teodor SALMEN, Tiberiu Augustin GEORGESCU, Simona-Gabriela TUDORACHE, Cristina-Daniela ENACHE, and Radu VLADAREANU. "Stem cells role in regenerative medicine." Romanian Journal of Medical Practice 16, no. 4 (December 31, 2021): 428–33. http://dx.doi.org/10.37897/rjmp.2021.4.4.

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Stem cells are precursor cells capable of self-renew and of generating numerous mature cell types. As the field of human embryonic stem cells harvesting has been put under questionable ethic issues, other sources are under investigation and present tremendous potential: tissue specific progenitor stem cells, mesenchymal stem cells, umbilical cord cells, bone marrow stem cells, and induced pluripotent stem cells. Stem cells interest different departments of regenerative medicine as well as conservative wildlife. Stem cells might be a viable option for the treatment of pathologies such as spinal injuries, cardiovascular disease, diabetes, liver injuries or even osteoarthritis. Scientists are looking forward to developing molecules that can activate tissue specific stem cells, promote stem cells to migrate to the side of tissue injury, and promote their differentiation to tissue specific cells, so that many health issues could have an alternative and efficient treatment and or even be cured.
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6

Han, Yu, Xuezhou Li, Yanbo Zhang, Yuping Han, Fei Chang, and Jianxun Ding. "Mesenchymal Stem Cells for Regenerative Medicine." Cells 8, no. 8 (August 13, 2019): 886. http://dx.doi.org/10.3390/cells8080886.

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In recent decades, the biomedical applications of mesenchymal stem cells (MSCs) have attracted increasing attention. MSCs are easily extracted from the bone marrow, fat, and synovium, and differentiate into various cell lineages according to the requirements of specific biomedical applications. As MSCs do not express significant histocompatibility complexes and immune stimulating molecules, they are not detected by immune surveillance and do not lead to graft rejection after transplantation. These properties make them competent biomedical candidates, especially in tissue engineering. We present a brief overview of MSC extraction methods and subsequent potential for differentiation, and a comprehensive overview of their preclinical and clinical applications in regenerative medicine, and discuss future challenges.
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7

EMA, Hideo, and Hiromitsu NAKAUCHI. "Hematopoietic Stem Cells for Regenerative Medicine." TRENDS IN THE SCIENCES 14, no. 8 (2009): 16–23. http://dx.doi.org/10.5363/tits.14.8_16.

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8

Verdi, Javad, Aaron Tan, Alireza Shoae-Hassani, and Alexander M. Seifalian. "Endometrial stem cells in regenerative medicine." Journal of Biological Engineering 8, no. 1 (2014): 20. http://dx.doi.org/10.1186/1754-1611-8-20.

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9

Sumer, Huseyin, Jun Liu, and Sangho Roh. "Mesenchymal Stem Cells and Regenerative Medicine." Stem Cells International 2018 (October 29, 2018): 1–3. http://dx.doi.org/10.1155/2018/9810972.

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10

Ilic, D., and J. M. Polak. "Stem cells in regenerative medicine: introduction." British Medical Bulletin 98, no. 1 (May 11, 2011): 117–26. http://dx.doi.org/10.1093/bmb/ldr012.

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11

The Lancet. "Stem cells, regenerative medicine, and Prometheus." Lancet 391, no. 10123 (March 2018): 814. http://dx.doi.org/10.1016/s0140-6736(18)30548-8.

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12

Sugiura, Risa, Sayuri Hamano, Atsushi Tomokiyo, Daigaku Hasegawa, Shinichiro Yoshida, Hideki Sugii, Shoko Fujino, et al. "PAX9 Is Involved in Periodontal Ligament Stem Cell-like Differentiation of Human-Induced Pluripotent Stem Cells by Regulating Extracellular Matrix." Biomedicines 10, no. 10 (September 22, 2022): 2366. http://dx.doi.org/10.3390/biomedicines10102366.

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Periodontal ligament stem cells (PDLSCs) play central roles in periodontal ligament (PDL) tissue homeostasis, repair, and regeneration. Previously, we established a protocol to differentiate human-induced pluripotent stem cell-derived neural crest-like cells (iNCs) into PDLSC-like cells (iPDLSCs) using human PDL cell-derived extracellular matrix (ECM). However, it remained unclear what factors principally regulate the differentiation of iNCs into iPDLSCs. In this study, we aimed to identify the transcription factor regulating production of human PDL cell-derived ECM, which is responsible for the generation of iPDLSCs. We cultured iNCs on ECMs of two human PDL cell lines (HPDLC-3S and HPDLC-3U) and of human dermal fibroblasts (HDF). iNCs cultured on HPDLC-3U demonstrated higher iPDLSC-associated gene expression and mesenchymal differentiation capacity than cells cultured on HDF or HPDLC-3S. The transcription factor PAX9 was highly expressed in HPDLC-3U compared with HDF and HPDLC-3S. iNCs cultured on siPAX9-transfected HPDLC-3U displayed downregulation of iPDLSC-associated marker expression and adipocytic differentiation capacity relative to controls. Our findings suggest that PAX9 is one of the transcription factors regulating ECM production in human PDL cells, which is responsible for the differentiation of iNCs into iPDLSCs.
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13

Tayal, Erika. "Dental Stem Cells: Part of Regenerative Medicine." International Journal of Preventive and Clinical Dental Research 3, no. 4 (2016): 277–81. http://dx.doi.org/10.5005/jp-journals-10052-0061.

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14

Li, Jin, Gehua Zhen, Shin-Yi Tsai, and Xiaofeng Jia. "Epidermal Stem Cells in Orthopaedic Regenerative Medicine." International Journal of Molecular Sciences 14, no. 6 (May 31, 2013): 11626–42. http://dx.doi.org/10.3390/ijms140611626.

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15

Suemori, Hirofumi, and Norio Nakatsuji. "Regenerative medicine using primate embryonic stem cells." Drug Delivery System 16, no. 1 (2001): 17–22. http://dx.doi.org/10.2745/dds.16.17.

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16

Brunt, Keith R., Richard D. Weisel, and Ren-Ke Li. "Stem cells and regenerative medicine — future perspectives." Canadian Journal of Physiology and Pharmacology 90, no. 3 (March 2012): 327–35. http://dx.doi.org/10.1139/y2012-007.

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Stem cell research has expanded at an exponential rate, but its therapeutic applications have progressed much more slowly. Currently, the research focuses on understanding embryonic, adult, and inducible pluripotent stem cells. Translation of adult stem cell research has established a definitive benefit that is greater than that of the current standard of care in the field of cardiovascular medicine. The future of stem cell research and therapy will continue to provide novel avenues of diagnostics, therapeutics, and tissue regeneration. Here we discuss a brief history of stem cell research as it transitioned from the 20th to the 21st century. We address lessons learned in the first decade of the new millennium that could help guide others to translate research into therapy across disciplines. Finally, we highlight future goals and challenges that must be overcome and offer some perspective on the bright future of stem cell research and therapy.
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17

Hirschi, Karen K., Song Li, and Krishnendu Roy. "Induced Pluripotent Stem Cells for Regenerative Medicine." Annual Review of Biomedical Engineering 16, no. 1 (July 11, 2014): 277–94. http://dx.doi.org/10.1146/annurev-bioeng-071813-105108.

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18

Kolios, George, and Yuben Moodley. "Introduction to Stem Cells and Regenerative Medicine." Respiration 85, no. 1 (2013): 3–10. http://dx.doi.org/10.1159/000345615.

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19

Bouros, Demosthenes, and Geoff Laurent. "Regenerative Medicine and Stem Cells: Prometheus Revisited." Respiration 85, no. 1 (2013): 1–2. http://dx.doi.org/10.1159/000345622.

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20

Hollands, P., D. Aboyeji, and M. Orcharton. "Dental pulp stem cells in regenerative medicine." British Dental Journal 224, no. 9 (May 2018): 747–50. http://dx.doi.org/10.1038/sj.bdj.2018.348.

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21

STOCUM, DAVID L. "Stem cells in regenerative biology and medicine." Wound Repair and Regeneration 9, no. 6 (November 2001): 429–42. http://dx.doi.org/10.1046/j.1524-475x.2001.00429.x.

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22

Ricard-Blum, S. "“Regenerative medicine: Stem cells and extracellular matrix”." Pathologie Biologie 57, no. 4 (June 2009): 281. http://dx.doi.org/10.1016/j.patbio.2008.09.008.

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23

Cossu, Giulio, Martin Birchall, Tracey Brown, Paolo De Coppi, Emily Culme-Seymour, Sahra Gibbon, Julian Hitchcock, et al. "Lancet Commission: Stem cells and regenerative medicine." Lancet 391, no. 10123 (March 2018): 883–910. http://dx.doi.org/10.1016/s0140-6736(17)31366-1.

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24

Hipp, Jennifer, and Anthony Atala. "Sources of Stem Cells for Regenerative Medicine." Stem Cell Reviews 4, no. 1 (February 20, 2008): 3–11. http://dx.doi.org/10.1007/s12015-008-9010-8.

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25

Bani-Yaghoub, Mahmud, Patricia Wilson, Markus Hengstschläger, Toshio Nikaido, and Duanqing Pei. "Amniotic Stem Cells: Potential in Regenerative Medicine." Stem Cells International 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/530674.

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26

Gimble, Jeffrey M., Adam J. Katz, and Bruce A. Bunnell. "Adipose-Derived Stem Cells for Regenerative Medicine." Circulation Research 100, no. 9 (May 11, 2007): 1249–60. http://dx.doi.org/10.1161/01.res.0000265074.83288.09.

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27

Alison, MR. "Stem cells in pathobiology and regenerative medicine." Journal of Pathology 217, no. 2 (December 16, 2008): 141–43. http://dx.doi.org/10.1002/path.2497.

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28

Chen, Yuh-Chi, Kung-Lin Tsai, Chia-Wei Hung, Dah-Ching Ding, Lih-Hsin Chen, Yuh-Lih Chang, Liang-Kung Chen, and Shih-Hwa Chiou. "Induced pluripotent stem cells and regenerative medicine." Journal of Clinical Gerontology and Geriatrics 2, no. 1 (March 2011): 1–6. http://dx.doi.org/10.1016/j.jcgg.2010.12.003.

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29

Park, Dong-Hyuk, David J. Eve, Yong-Gu Chung, and Paul R. Sanberg. "Regenerative Medicine for Neurological Disorders." Scientific World JOURNAL 10 (2010): 470–89. http://dx.doi.org/10.1100/tsw.2010.39.

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The annual meeting of the American Society for Neural Therapy and Repair (ASNTR) has always introduced us to top-notch and up-to-date approaches for regenerative medicine related to neuroscience, ranging from stem cell–based therapy to novel drugs. The 16th ASNTR meeting focused on a variety of different topics, including the unknown pathogenesis or mechanisms of specific neurodegenerative diseases, stem cell biology, and development of novel alternative medicines or devices. Newly developed stem cells, such as amniotic epithelial stem cells and induced pluripotent stem cells, as well as well-known traditional stem cells, such as neural, embryonic, bone marrow mesenchymal, and human umbilical cord blood–derived stem cells, were reported. A number of commercialized stem cells were also covered at this meeting. Fetal neural tissues, such as ventral mesencephalon, striatum, and Schwann cells, were investigated for neurodegenerative diseases or spinal cord injury. A number of studies focused on novel methods for drug monitoring or graft tracking, and combination therapy with stem cells and medicine, such as cytokines or trophic factors. Finally, the National Institutes of Health guidelines for human stem cell research, clinical trials of commercialized stem cells without larger animal testing, and prohibition of medical tourism were big controversial issues that led to heated discussion.
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30

Alshoubaki, Yasmin K., Bhavana Nayer, Surojeet Das, and Mikaël M. Martino. "Modulation of the Activity of Stem and Progenitor Cells by Immune Cells." Stem Cells Translational Medicine 11, no. 3 (March 1, 2022): 248–58. http://dx.doi.org/10.1093/stcltm/szab022.

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Abstract Numerous components of the immune system, including inflammatory mediators, immune cells and cytokines, have a profound modulatory effect on the homeostatic regulation and regenerative activity of endogenous stem cells and progenitor cells. Thus, understanding how the immune system interacts with stem/progenitor cells could build the foundation to design novel and more effective regenerative therapies. Indeed, utilizing and controlling immune system components may be one of the most effective approaches to promote tissue regeneration. In this review, we first summarize the effects of various immune cell types on endogenous stem/progenitor cells, focusing on the tissue healing context. Then, we present interesting regenerative strategies that control or mimic the effect of immune components on stem/progenitor cells, in order to enhance the regenerative capacity of endogenous and transplanted stem cells. We highlight the potential clinical translation of such approaches for multiple tissues and organ systems, as these novel regenerative strategies could considerably improve or eventually substitute stem cell-based therapies. Overall, harnessing the power of the cross-talk between the immune system and stem/progenitor cells holds great potential for the development of novel and effective regenerative therapies.
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31

Mahla, Ranjeet Singh. "Stem Cells Applications in Regenerative Medicine and Disease Therapeutics." International Journal of Cell Biology 2016 (2016): 1–24. http://dx.doi.org/10.1155/2016/6940283.

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Regenerative medicine, the most recent and emerging branch of medical science, deals with functional restoration of tissues or organs for the patient suffering from severe injuries or chronic disease. The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by conventional medicines. The indefinite self-renewal and potential to differentiate into other types of cells represent stem cells as frontiers of regenerative medicine. The transdifferentiating potential of stem cells varies with source and according to that regenerative applications also change. Advancements in gene editing and tissue engineering technology have endorsed the ex vivo remodelling of stem cells grown into 3D organoids and tissue structures for personalized applications. This review outlines the most recent advancement in transplantation and tissue engineering technologies of ESCs, TSPSCs, MSCs, UCSCs, BMSCs, and iPSCs in regenerative medicine. Additionally, this review also discusses stem cells regenerative application in wildlife conservation.
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32

Finkel, Elizabeth. "Stem cells in brain have regenerative potential." Lancet 347, no. 9003 (March 1996): 751. http://dx.doi.org/10.1016/s0140-6736(96)90093-8.

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33

Ulery, Bret D. "Stem cells flex their muscle regenerative potential." Science Translational Medicine 8, no. 342 (June 8, 2016): 342ec93. http://dx.doi.org/10.1126/scitranslmed.aag1872.

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34

Dokshin, P. M., and A. B. Malashicheva. "Heart stem cells: hope or myth?" Russian Journal of Cardiology 26, no. 10 (November 22, 2021): 4749. http://dx.doi.org/10.15829/1560-4071-2021-4749.

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The search and study of endogenous heart repair remains an urgent issue in modern regenerative medicine. It is generally accepted that the human heart has a limited regenerative potential, but recent studies show that functionally significant regeneration is possible. However, the mechanisms underlying these processes remain poorly understood. In the heart, there are populations of resident mesenchymal cells that have some properties of stem cells that carry certain markers, such as c-kit+, Sca-1, etc. The ability of these cells to differentiate directly into cardiomyocytes remains controversial, but their use in clinical trials has shown improved cardiac function in patients with myocardial infarction. Currently, approaches are being developed to use, mainly, induced pluripotent stem cells as a promising regenerative therapy, but the cardioprotective role of cardiac mesenchymal cells remains the subject of active study due to their paracrine signaling.
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35

Lyzikov, A. N., B. B. Osipov, A. G. Skuratov, and A. A. Prizentsov. "STEM CELLS IN REGENERATIVE MEDICINE: ACHIEVEMENTS AND PROSPECTS." Health and Ecology Issues, no. 3 (September 28, 2015): 4–8. http://dx.doi.org/10.51523/2708-6011.2015-12-3-1.

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Purpose: to analyze achievements and prospects of the application of stem cells in regenerative medicine. Material and methods. We performed analytical review of national and foreign literature, Internet resources in PubMed and others dealing with the apоplication of stem cells in regenerative medicine. Results. Rich experience of experimental and clinical application of stem cells in the treatment of cardiovascular, neurological, endocrine, hematological, autoimmune, traumatological, and other diseases has been gained by now. Conclusion. Notwithstanding the success and achievements in regenerative medicine during the recent years, a lot of problems and questions remain unsolved. The application of both embryonic stem cells and postnatal stem cells has its pros and cons. The exact mechanism of the effect of transplanted stem cells remains unclear. It is necessary to study long-term effects of stem cell therapy (in particular, the risk of oncogenesis).
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36

Bhartiya, Deepa. "Stem cells, progenitors & regenerative medicine: A retrospection." Indian Journal of Medical Research 141, no. 2 (2015): 154. http://dx.doi.org/10.4103/0971-5916.155543.

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37

Zehravi, Mehwish, Osama Shahid, Ayesha Kashmala, Fareeha Faizan, and Mohsin Wahid. "Stem Cells in Regenerative Medicine: Prospects and Pitfalls." National Journal of Health Sciences 2, no. 3 (August 31, 2017): 116–22. http://dx.doi.org/10.21089/njhs.23.0116.

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38

Talwar, Pankaj. "Human embryonic stem cells - role in regenerative medicine." Journal of Marine Medical Society 14, no. 1 (2012): 36. http://dx.doi.org/10.4103/0975-3605.203228.

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39

Deogade, SuryakantC, Sonalika Ghate, Gunjan Dube, SumathiK Nitin, Prashant Dube, Utkarsh Katare, Divya Katare, and Shreyansh Damade. "Application of dental stem cells in regenerative medicine." Annals of Nigerian Medicine 9, no. 2 (2015): 41. http://dx.doi.org/10.4103/0331-3131.177944.

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40

Massasa, Efi E., and Hugh S. Taylor. "Use of endometrial stem cells in regenerative medicine." Regenerative Medicine 7, no. 2 (March 2012): 133–35. http://dx.doi.org/10.2217/rme.11.123.

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41

Zippel, Nina, Margit Schulze, and Edda Tobiasch. "Biomaterials and Mesenchymal Stem Cells for Regenerative Medicine." Recent Patents on Biotechnology 4, no. 1 (January 1, 2010): 1–22. http://dx.doi.org/10.2174/187220810790069497.

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42

Prentice, David A. "Current Science of Regenerative Medicine with Stem Cells." Journal of Investigative Medicine 54, no. 1 (January 1, 2006): 33–37. http://dx.doi.org/10.2310/6650.2005.05043.

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43

Kariminekoo, Saber, Aliakbar Movassaghpour, Amirbahman Rahimzadeh, Mehdi Talebi, Karim Shamsasenjan, and Abolfazl Akbarzadeh. "Implications of mesenchymal stem cells in regenerative medicine." Artificial Cells, Nanomedicine, and Biotechnology 44, no. 3 (January 13, 2016): 749–57. http://dx.doi.org/10.3109/21691401.2015.1129620.

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44

Bhartiya, Deepa. "Clinical Translation of Stem Cells for Regenerative Medicine." Circulation Research 124, no. 6 (March 15, 2019): 840–42. http://dx.doi.org/10.1161/circresaha.118.313823.

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45

Hoffmann, Werner, and Shree Ram Singh. "Editorial (Stem Cells in Regenerative Medicine and Cancer)." Current Medicinal Chemistry 19, no. 35 (December 1, 2012): 5964. http://dx.doi.org/10.2174/092986712804485908.

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46

Forbes, S. J. "Recent advances in stem cells and regenerative medicine." QJM 107, no. 4 (February 6, 2014): 251–52. http://dx.doi.org/10.1093/qjmed/hcu032.

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47

Huard, Johnny, Burhan Gharaibeh, and Arvydas Usas. "Regenerative Medicine Based on Muscle-Derived Stem Cells." Operative Techniques in Orthopaedics 20, no. 2 (June 2010): 119–26. http://dx.doi.org/10.1053/j.oto.2009.10.013.

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48

Eaves, Connie. "Stem Cells and the Future of Regenerative Medicine." Nature Medicine 8, no. 4 (April 2002): 326. http://dx.doi.org/10.1038/nm0402-326.

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49

Frese, Laura, Petra E. Dijkman, and Simon P. Hoerstrup. "Adipose Tissue-Derived Stem Cells in Regenerative Medicine." Transfusion Medicine and Hemotherapy 43, no. 4 (2016): 268–74. http://dx.doi.org/10.1159/000448180.

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50

Ishizaka, Yukihito, and Tomoki Takashina. "Induced Pluripotent Stem Cells for Novel Regenerative Medicine." Global Journal of Human Genetics & Gene Therapy 1, no. 2 (February 2014): 57–66. http://dx.doi.org/10.14205/2311-0309.2013.01.02.2.

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