Dissertations / Theses on the topic 'Regenerative medicine (incl. stem cells)'
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Prasongchean, W. "Somatic stem cells : properties and potential for regenerative medicine." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1336076/.
Full textWong, J. W. "Centrifugal recovery of embryonic stem cells for regenerative medicine bioprocessing." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/16358/.
Full textChu, Pui Kei Carol. "The bioprocessing of stem cells for use in regenerative medicine." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/17422/.
Full textPerruisseau-Carrier, Claire. "Neuronal commitment of Umbilical Cord Mesenchymal Stem Cells for brain regenerative medicine." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10192.
Full textNowadays, no effective prevention or cure of human brain diseases is available. Stem cells hold great promise for the repair and regeneration of damaged neural tissues. This thesis aims to evaluate the potency of human umbilical cord mesenchymal stem cells (hUC MSCs) to be committed to the neuronal lineage, for brain cell-based therapy. To achieve this goal, naive hUC MSCs were isolated, expanded, and characterized at the gene and protein level, while particularly focusing on the neuronal lineage and clinical-grade culture conditions. Then, several parameters were investigated for hUC MSCs proliferation and neuronal commitment, including media, coatings, 3D culture, hypoxia, chemicals and molecules. Growth curves drawings, qPCRs, and immunostainings were used among other methods for identifying the best conditions for hUC MSCs expansion, differentiation, culture in 3D, and microRNAs delivery. The results indicate that hUC MSCs better proliferate in serum-free media and brain's normoxia condition (1-5 % O2). Naive hUC MSCs appear primed for neuronal fate at gene and protein level, but not su_ciently to support their neuronal di_erentiation. microRNAs delivery requires further improvement to efficiently promote neuronal signaling pathways in hUC MSCs. Along this study we identified the best parameters for hUC MSCs expansion in clinical-grade conditions. However, a question still remains: are hUC MSCs capable of full transdifferentiation towards functional neurons despite all controversies? Additional work is needed, but this study is a first step towards answering this question, bringing more clues to make transplantation of hUC MSCs for brain regenerative medicine closer
Sutha, Ken. "Osteoinductive material derived from differentiating embryonic stem cells." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/51722.
Full textSrivastava, Sapna. "The potential of human adipose derived stem cells for myocardial regenerative therapy." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95088.
Full textLa thérapie cellulaire à l'aide de cellules souches humaines de la moelle osseuses (CSHMOs) a été démontré d'améliorer la fonction cardiaque après un infarctus du myocarde. La technique de récolte des CSHMOs est pourtant invasive et donne un nombre de cellules viables faible. Il y a maintenant un intérêt croissant dans les cellules souches humaines dérivés du tissu adipeux (CSHTAs), car elles sont abondantes et facilement accessibles à partir des amas de graisses provenant des chirurgies de liposuccion. La présente étude a été menée pour vérifier si les CSHTAs sont supérieures aux CSHMOs dans la thérapie régénératrice du myocarde. Résultats: Les CSHTAs ainsi que les CSHMOs ont proliféré dans une manière temps dépendante, cependant, la capacité proliférative des CSHTAs était supérieure à celle des CSHMOs. De plus, les deux types de cellules souches ce sont différenciées en lignée ostéoblastique, affirmant leur capacité multipotent lorsqu'elles sont traitées avec le milieu d'induction. En outre, le traitement des deux types de cellules souches avec le 5-AC a entraîné l'immunomarquage positif de troponin I et de connexine 43, marqueurs cardiaques, cependant l'expression de ces marqueurs était plus robuste dans les CSHTAs. Cela a été confirmé par analyse d'immunobuvardage de type Western, cependant les cellules traité au 5-AC ne présentait pas de contraction des cellules ou le développement de plusieurs noyaux. En plus, ces résultats ont été confirmés par nos études in vivo. Les deux types de cellules ont été injectées dans le cur d'un modèle de rat d'infarctus du myocarde et a été suivie pour la fraction d'éjection (FE) et la fraction de raccourcissement (FR) pour 24 heures, 3 semaines et 6 semaines post-chirurgie. La fonction cardiaque des rats traités avec les cellules souches a été améliorée, fait démontré par l'augmentation de l'FE et le FR, cependant, une plus grande amélioration de ce
Yasin, Mohammed. "Non-regenerative benefits of adult bone marrow derived stem cells for myocardial protection." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8701.
Full textWilliams, Kaylyn Renee. "In Vitro Models of Cellular Dedifferentiation for Regenerative Medicine." Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/83715.
Full textMaster of Science
Mohrman, Ashley E. "Regenerative Medicine Approaches to Spinal Cord Injury." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1491495476427594.
Full textSingh, Pawanbir. "Enabling late-stage translation of regenerative medicine based products." Thesis, Loughborough University, 2010. https://dspace.lboro.ac.uk/2134/6060.
Full textWang, Yinxiang, and 王胤祥. "Induction of cells with osteo-chondrogenic potential by transcription factor-mediated reprogramming process." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/207993.
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Biochemistry
Doctoral
Doctor of Philosophy
TAKEI, YOSHIFUMI, KENJI KADOMATSU, KAORI YASUDA, and NAOSHI KOIDE. "ESTABLISHMENT AND OPTIMAL CULTURE CONDITIONS OF MICRORNA-INDUCED PLURIPOTENT STEM CELLS GENERATED FROM HEK293 CELLS VIA TRANSFECTION OF MICRORNA-302S EXPRESSION VECTOR." Nagoya University School of Medicine, 2012. http://hdl.handle.net/2237/16033.
Full textSunohara, Tadashi. "MicroRNA-based separation of cortico-fugal projection neuron-like cells derived from embryonic stem cells." Kyoto University, 2020. http://hdl.handle.net/2433/253176.
Full textYoungstrom, Daniel W. "Mesenchymal Stem Cell Mechanobiology and Tendon Regeneration." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/64422.
Full textPh. D.
Hoover, Brett A. "Smart Cellector: A Proposal for the Development and Commercialization of a Cellular Imaging, Analysis and Processing Technology for Application in Regenerative Medicine." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1295655205.
Full textHackett, Simon Marc. "Addressing the immunological barriers to regenerative medicine : differentiation and characterisation of dendritic cells derived from induced pluripotent stem cells." Thesis, University of Oxford, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.644988.
Full textMiller, Angela. "Peptide based hydrogels in the study of mesenchymal stem cells for the purposes of regenerative medicine." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6880/.
Full textPopielarczyk, Tracee. "Homing and Differentiation of Mesenchymal Stem Cells in 3D In Vitro Models." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/78789.
Full textPh. D.
Jackson, JeShaune D. Jackson. "Bench to Bone: Commercializing a Cellular Therapeutic for Regenerative Medicine." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1521472107740449.
Full textSheard, Jonathan. "Screening and improving the safe provision of mesenchymal stem cells in regenerative medicine : an in vitro study." Thesis, Aston University, 2016. http://publications.aston.ac.uk/30085/.
Full textLazin, Jamie Jonas. "The effect of age and sex on the number and osteogenic differentiation potential of adipose-derived mesenchymal stem cells." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34696.
Full textNair, Rekha. "Acellular matrices derived from differentiating embryonic stem cells." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37170.
Full textCoffin, Spencer. "Extending the Window of Use for Human Mesenchymal Stem Cell Seeded Biological Sutures." Digital WPI, 2015. https://digitalcommons.wpi.edu/etd-theses/510.
Full textNsiah, Barbara Akua. "Fluid shear stress modulation of embryonic stem cell differentiation." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/47552.
Full textDahal, Shataakshi. "Stem Cells Based Elastic Matrix Regeneration for Small Abdominal Aortic Aneurysms (AAAs) Repair." Cleveland State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=csu1599137475237285.
Full textDahal, Shataakshi. "Stem Cells Based Elastic Matrix Regeneration for Small Abdominal Aortic Aneurysms (AAAs) Repair." Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1599137475237285.
Full textBogers, Sophie Helen. "Turning Round: Optimizing the Anti-Inflammatory Properties of Equine Bone Marrow Derived Mesenchymal Stem Cells for Osteoarthritis Through Three-Dimensional Culture." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/81746.
Full textPh. D.
Francis, Michael. "RECAPITULATING OSTEOBLASTOGENESIS WITH ELECTROSPUN FIBRINOGEN NANOFIBERS AND ADIPOSE STEM CELLS AND ELECTROSPINNING ADIPOSE TISSUE-DERIVED BASEMENT MEMBRANE." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2025.
Full textChan, Alexander K. C. "Development of characterisation and quality potency assays for human mesenchymal stem cells." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/22977.
Full textDosier, Christopher R. "Bone tissue engineering utilizing adult stem cells in biologically functionalized hydrogels." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/47678.
Full textAndré, Emilie. "Combination of nano and microcarriers for stem cell therapy of Huntington's disease : new regenerative medicine strategy." Thesis, Angers, 2015. http://www.theses.fr/2015ANGE0047/document.
Full textThe combination of biomaterials and stem cells aims to protect damaged cells and slow the progression of neurodegenerative diseases such as Huntington's disease(HD). Mesenchymal stem cells, particularly a subpopulation known as MIAMI cells, have already demonstrated their effectiveness in Parkinson's disease. However, it is essential to improve their neuronal differentiation, survival, and to assess their secretome. The main objective of this work was to propose an innovative regenerative medicine strategy for HD by combining stemcells, micro and nano medicines. To perform this assessment, a new ex vivo animal model of HD has been set up. We then developed and optimized two nanovectors,lipid nanocapsules and solid SPAN nanoparticles,carrying an inhibitor of REST a transcription factor, which prevents neuronal differentiation. The transfection of this siREST showed an improvement in the neuronal phenotype. These modified cells were then induced into a GABAergic phenotype through growth factors. They were then associated with a 3D support, the pharmacologically active microcarriers (PAM) allowing a high rate of engraftment. The PAM are microspheres which have a biomimetic surface of laminin and release a trophic factor BDNF, brain derived neurotrophic factor (inducer of a neural phenotype and neuroprotective) in a controlled manner. Promising results were obtained, further encouraging continuing the evaluation of this strategy in vivo in genetic models of HD
Webber, Nicholas R. "Technology and Commercial Assessment of a Tissue Regenerating Drug in the Regenerative Medicine Market." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1402249985.
Full textChilton, Jamie Meredith. "Investigation of the limitations of viral gene transfer to murine embryonic stem cells." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/29745.
Full textCommittee Chair: Joseph Le Doux; Committee Member: Anthanassios Sambanis; Committee Member: David Archer; Committee Member: Michelle LaPlaca; Committee Member: Steve Stice; Committee Member: Todd McDevitt. Part of the SMARTech Electronic Thesis and Dissertation Collection.
Nakamura, Sou. "Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells." Kyoto University, 2015. http://hdl.handle.net/2433/202779.
Full textBargehr, Johannes. "The role of human embryonic stem cell-derived epicardium in myocardial graft development." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/276112.
Full textReisbig, Nathalie A. "Synovial Extracellular Matrix and Synovial Mesenchymal Stem Cells are Chondrogenic In Vitro and In Vivo." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543150403002824.
Full textDrury-Stewart, Danielle Nicole. "Controlling the microenvironment of human embryonic stem cells: maintenance, neuronal differentiation, and function after transplantation." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45967.
Full textBratt-Leal, Andrés Miguel. "Biomaterial integration within 3D stem cell aggregates for directed differentiation." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45934.
Full textRafiq, Qasim Ali. "Developing a standardised manufacturing process for the clinical-scale production of human mesenchymal stem cells." Thesis, Loughborough University, 2013. https://dspace.lboro.ac.uk/2134/12335.
Full textNakane, Takeichiro. "Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue." Kyoto University, 2018. http://hdl.handle.net/2433/232090.
Full textRönsch, Kathleen. "Patterning of stem cells during limb regeneration in Ambystoma mexicanum." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-232386.
Full textCarpenedo, Richard L. "Microsphere-mediated control of embryoid body microenvironments." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/33948.
Full textTorres, Fabrício Carvalho. "Panículo adiposo interescapular de coelho da espécie Oryctolagus cuniculus como fonte de células-tronco." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-31082009-162219/.
Full textIn the latest years, the study on tissue engineering, mainly in the area of regenerative medicine, has advanced because the medical community is highly interested in stem cells. This is due to both the potential of these cells to originate any body tissue and their power of self-renewal. Adipose tissue has been used as an ideal source of such cells, due to the simplicity of their collection, high cellular yield, and low morbidity associated with the procedure. In order to establish a versatile experimental model, which could meet the needs of researchers from various areas, the rabbit Oryctolagus cuniculus was proposed as a source of adipose tissue. This animal has an adipose pad in the interscapular region with an average weight of 17.2g, which corresponds to about 6.6g of fat material per kilogram of an adult male animal (mean body weight = 2.6kg). The material was collected by means of a liposuction procedure. Using a 3.5- mm diameter tube, a volume of nearly 10ml of fat material was obtained in a mean time of 11min. After processing the fat tissue by enzymatic technique, about 1x105 stem cells were found per milliliter of fat material. Using cryopreservation of the cells by freezing them in liquid nitrogen, it was observed that the cytometric characteristics were maintained after a period of time ranging from 1 week to 13 months. The cells presented evident characteristics of undifferentiation, such as expression of the surface markers CD90, HLA-DR, and Caspase-3 (80.6, 2.8, and 10.5 %, respectively). Analysis of the cellular cycle with 100% confluence allowed us to show that 70.8% of the cells were quiescent, 22.1% were apoptotic, 1.4% had high replication capacity (phase S of the cellular cycle) and 0.9% were already in replication (phase G2/M), indicating that stem cells from adipose tissue did not show uncontrolled proliferation, tending to stabilize, mainly when they reach maximal confluence in monolayer. These advantages make this model easily reproducible, facilitating the study of adipose tissue stem cells.
Alt, Daniel Scott. "PREVASCULAR CELL CONDENSATIONS FOR MODULAR TISSUE ENGINEERING." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1599521079956842.
Full textKinney, Melissa. "Biophysical and biochemical control of three-dimensional embryonic stem cell differentiation and morphogenesis." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53465.
Full textKaur, Navdeep. "Influence of culture conditions on the molecular signature of mesenchymal stem cells." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/43719/1/Navdeep_Kaur_Thesis.pdf.
Full textShafiee, Abbas. "Isolation and characterisation of primitive stem cell populations from placenta." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/95086/1/Abbas_Shafiee_Thesis.pdf.
Full textHeathman, Thomas R. J. "Developing a process control strategy for the consistent and scalable manufacture of human mesenchymal stem cells." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/22174.
Full textSpeccher, Alessandra. "Tissue engineering approaches for brain injury applications." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/262798.
Full textFotticchia, Andrea. "Design and development of anisotropic laminate scaffolds of electrospun polycaprolactone for annulus fibrosus tissue engineering applications." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/21407.
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