Journal articles: 'Regenerative change'

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Green, Eric M., and Richard T. Lee. "Proteins and Small Molecules for Cellular Regenerative Medicine." Physiological Reviews 93, no. 1 (January 2013): 311–25. http://dx.doi.org/10.1152/physrev.00005.2012.

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Regenerative medicine seeks to understand tissue development and homeostasis and build on that knowledge to enhance regeneration of injured tissues. By replenishing lost functional tissues and cells, regenerative medicine could change the treatment paradigm for a broad range of degenerative and ischemic diseases. Multipotent cells hold promise as potential building blocks for regenerating lost tissues, but successful tissue regeneration will depend on comprehensive control of multipotent cells–differentiation into a target cell type, delivery to a desired tissue, and integration into a durable functional structure. At each step of this process, proteins and small molecules provide essential signals and, in some cases, may themselves act as effective therapies. Identifying these signals is thus a fundamental goal of regenerative medicine. In this review we discuss current progress using proteins and small molecules to regulate tissue regeneration, both in combination with cellular therapies and as monotherapy.

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Kim, Sang-Soo, and Yohji Okada. "Variable Resistance Type Energy Regenerative Damper Using Pulse Width Modulated Step-up Chopper." Journal of Vibration and Acoustics 124, no. 1 (July 1, 2001): 110–15. http://dx.doi.org/10.1115/1.1419204.

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This paper describes a new technique for improving the damping property and efficiency of an energy regenerative damper. It is intended for a linear DC motor type vibration damper to regenerate vibration energy efficiently. Normally a regenerative damper can regenerate vibration energy only at high speed motion. For low speed motion, the damper has nonlinear characteristics with dead zone and cannot regenerate energy. In order to overcome this problem, a step-up chopper is introduced between the actuator and the charging circuit. The energy is regenerated from low speed and low voltage actuator to high voltage charging circuit. This paper also proposes a new control technique to the step-up chopper by using pulse width modulated signals. The damper can change its damping coefficient and the energy can be regenerated more efficiently. The proposed damper is applied to an active mass damper system. A simple experimental setup is used to validate the proposed technique. The results show an increase in performance and energy regeneration as compared to the previously proposed regenerative damper.

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Brockes, Jeremy P., and Phillip B. Gates. "Mechanisms underlying vertebrate limb regeneration: lessons from the salamander." Biochemical Society Transactions 42, no. 3 (May 22, 2014): 625–30. http://dx.doi.org/10.1042/bst20140002.

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Limb regeneration in adult salamanders proceeds by formation of a mound of progenitor cells called the limb blastema. It provides several pointers for regenerative medicine. These include the role of differentiated cells in the origin of the blastema, the role of regenerating axons of peripheral nerves and the importance of cell specification in conferring morphogenetic autonomy on the blastema. One aspect of regeneration that has received less attention is the ability to undergo multiple episodes without detectable change in the outcome, and with minimal effect of aging. We suggest that, although such pointers are valuable, it is important to understand why salamanders are the only adult tetrapod vertebrates able to regenerate their limbs. Although this remains a controversial issue, the existence of salamander-specific genes that play a significant role in the mechanism of regeneration provides evidence for the importance of local evolution, rather than a purely ancestral mechanism. The three-finger protein called Prod1 is discussed in the present article as an exemplar of this approach.

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Zhang, Cheng Cai, Zhe Xiong, Zhi Gang Fang, and Xue Xun Guo. "The Operating Principle and Experimental Verification of the Hydraulic Electromagnetic Energy-Regenerative Shock Absorber." Advanced Materials Research 655-657 (January 2013): 1175–78. http://dx.doi.org/10.4028/www.scientific.net/amr.655-657.1175.

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This paper introduces a new type of shock absorber: hydraulic electromagnetic energy-regenerative shock absorber (HESA), which can simultaneously implement the function of damping vibration and regenerating a portion of dissipated energies generated from passing through the damping hole. A test bench was trial-produced and used to prove the feasibility of the energy-regenerative scheme. The situation that hydraulic motor rotational speed has a sudden change in the energy regenerating process is theoretically analyzed.

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Tavakoli, Javad, Ashish D. Diwan, and Joanne L. Tipper. "Advanced Strategies for the Regeneration of Lumbar Disc Annulus Fibrosus." International Journal of Molecular Sciences 21, no. 14 (July 10, 2020): 4889. http://dx.doi.org/10.3390/ijms21144889.

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Damage to the annulus fibrosus (AF), the outer region of the intervertebral disc (IVD), results in an undesirable condition that may accelerate IVD degeneration causing low back pain. Despite intense research interest, attempts to regenerate the IVD have failed so far and no effective strategy has translated into a successful clinical outcome. Of particular significance, the failure of strategies to repair the AF has been a major drawback in the regeneration of IVD and nucleus replacement. It is unlikely to secure regenerative mediators (cells, genes, and biomolecules) and artificial nucleus materials after injection with an unsealed AF, as IVD is exposed to significant load and large deformation during daily activities. The AF defects strongly change the mechanical properties of the IVD and activate catabolic routes that are responsible for accelerating IVD degeneration. Therefore, there is a strong need to develop effective therapeutic strategies to prevent or reconstruct AF damage to support operational IVD regenerative strategies and nucleus replacement. By the way of this review, repair and regenerative strategies for AF reconstruction, their current status, challenges ahead, and future outlooks were discussed.

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Sun, Dongsheng, Junzhi Zhang, Chengkun He, and Jinheng Han. "Dual-mode regenerative braking control strategy of electric vehicle based on active disturbance rejection control." Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering 235, no. 6 (January 17, 2021): 1483–96. http://dx.doi.org/10.1177/0954407020985642.

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The traditional regenerative braking control strategy usually uses the torque control mode and does not perform closed-loop control on the charging current, when the vehicle needs to be charged with a small current, the regenerative braking system cannot work effectively. The dual-mode regenerative braking control strategy proposed in this paper unifies the closed-loop control of regenerative current and the closed-loop control of regenerative torque. Especially when the battery is in a state of high charge or the temperature of the battery is too high or too low, this strategy can ensure charging safety, regeneration efficiency, and ride comfort. In the current closed-loop control mode, this proposal uses the ADRC controller to dynamically adjust the motor torque to achieve the purpose of accurately controlling the regenerative current. This method does not need to change the original vector control frame of the motor, which is convenient for engineering applications. The designed regenerative control strategy is verified through typical braking simulation. Bench tests are carried out and the results validate the feasibility and effectiveness of the designed strategy. Based on the realization of the safety of charging and the vehicle ride comfort, the proposed regenerative braking control strategy can achieve higher regeneration efficiency under the dynamical limitation of battery charging current, which further expands the operating range of the regenerative braking system.

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Böckelmann, PK, BS Ochandio, and IJ Bechara. "Histological study of the dynamics in epidermis regeneration of the carp tail fin (Cyprinus carpio, Linnaeus, 1758)." Brazilian Journal of Biology 70, no. 1 (February 2010): 217–23. http://dx.doi.org/10.1590/s1519-69842010000100030.

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Teleostean fins when partially amputated suffer a regenerative process called epimorphic regeneration, characterized by the following stages: healing, based on the formation of a multistratified epidermal layer, the formation of a mass of pluripotent cells known as blastema, the differentiation of these cells, the synthesis and disposition of the extracellular matrix, morphological growth and restoration. The epidermis has a fundamental role in the regenerative process of fish fins, as the healing time of this structure leads it to a faster regenerative process and it also works as a defense against the external environment. In this sense, due to the fast regeneration shown by the epidermis, the aim of this paper is to study the histology of the regenerative dynamics of the carp fin tail (Cyprinus carpio), under the light and transmission electron microscope. Epidermic regeneration begins right in the first hours after the fin amputation and it continues throughout the regenerative process. After 24 hours, an apical epidermal cap is established. Cytoplasmatic prolongations and intercellular junctions are observed and the cells of the basal layer of the epidermis change from the cubic form to the cylindrical, due to the development of the cytoplasmatic organelles responsible for the synthesis of the basal membrane, lost after amputation. These results show the importance of histological studies in regenerative processes. We believe that the association of molecular biology with histological studies can throw further light onto these regenerative dynamics.

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Nucci, R., A. Teodoro, and E. Gama. "Liver regeneration and aging: a review." Journal of Morphological Sciences 33, no. 04 (October 2016): 179–82. http://dx.doi.org/10.4322/jms.100616.

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AbstractWith the advance of age, a clinically significant change is a marked decline in the rate of hepatic regeneration. Many studies described the mechanisms involved in the hepatic regenerative process with experimental procedures such as partial hepatectomy. The aim of the present study was to elucidate the molecular and cellular mechanisms involved in liver regeneration due to partial hepatectomy and the effects of aging on these mechanisms. We used PubMed, MEDLINE and Scholar Google databases investigating the following keywords without restrictions: liver, regeneration, aging. We included research studies (animal and humans) and reviews published in English language that were related to the liver regeneration and the process of aging. The regeneration on liver involves multiple cellular processes and a complex interaction with cytokines and growth factors. The aging process affects liver causing a delay on its regeneration. In a clinical setting, the decline of hepatic regenerative capacity could be considered an important concern, because most of the elderly use different medications which could provide a liver injury, as well as, one of the methods used to remove neoplastic cells is the partial hepatectomy which depends of the individual regenerative capacity.

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Huang, Jinhui, Enrong Wang, and Hailong Zhang. "Analysis and Research on the Comprehensive Performance of Vehicle Magnetorheological Regenerative Suspension." Vehicles 2, no. 4 (October 22, 2020): 576–88. http://dx.doi.org/10.3390/vehicles2040033.

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Magnetorheological (MR) regenerative suspension system can not only achieve excellent comprehensive suspension performance but also effectively recover and utilize vibration potential energy, which has been a research hotspot in the field of vehicle engineering. In this paper, for the 1/4 vehicle’s MR regenerative suspension system parallel with a tubular permanent magnet linear motor (TPMLM), the dynamic model of the MR semi-active suspension system and the TPMLM finite element model are established separately to form a joint simulation platform. The simulation analysis of the comprehensive suspension performance and regeneration performance under different road excitations is performed. The results show that installing TPMLM does not change the natural resonance frequency of the suspension system, which ensures good driving comfort and handling stability. At the same time, it has considerable regeneration power. This research can provide a reference for the stability analysis and popularization of the vehicle’s MR regenerative suspension system.

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Järvinen, Tero A. H., and Toini Pemmari. "Systemically Administered, Target-Specific, Multi-Functional Therapeutic Recombinant Proteins in Regenerative Medicine." Nanomaterials 10, no. 2 (January 28, 2020): 226. http://dx.doi.org/10.3390/nano10020226.

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Growth factors, chemokines and cytokines guide tissue regeneration after injuries. However, their applications as recombinant proteins are almost non-existent due to the difficulty of maintaining their bioactivity in the protease-rich milieu of injured tissues in humans. Safety concerns have ruled out their systemic administration. The vascular system provides a natural platform for circumvent the limitations of the local delivery of protein-based therapeutics. Tissue selectivity in drug accumulation can be obtained as organ-specific molecular signatures exist in the blood vessels in each tissue, essentially forming a postal code system (“vascular zip codes”) within the vasculature. These target-specific “vascular zip codes” can be exploited in regenerative medicine as the angiogenic blood vessels in the regenerating tissues have a unique molecular signature. The identification of vascular homing peptides capable of finding these unique “vascular zip codes” after their systemic administration provides an appealing opportunity for the target-specific delivery of therapeutics to tissue injuries. Therapeutic proteins can be “packaged” together with homing peptides by expressing them as multi-functional recombinant proteins. These multi-functional recombinant proteins provide an example how molecular engineering gives to a compound an ability to home to regenerating tissue and enhance its therapeutic potential. Regenerative medicine has been dominated by the locally applied therapeutic approaches despite these therapies are not moving to clinical medicine with success. There might be a time to change the paradigm towards systemically administered, target organ-specific therapeutic molecules in future drug discovery and development for regenerative medicine.

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Ramage, Benjamin S., Kevin L. O’Hara, and Alison B. Forrestel. "Forest transformation resulting from an exotic pathogen: regeneration and tanoak mortality in coast redwood stands affected by sudden oak death." Canadian Journal of Forest Research 41, no. 4 (April 2011): 763–72. http://dx.doi.org/10.1139/x11-020.

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Sudden oak death is dramatically altering forests throughout coastal California, but little is known about the communities that are assembling in affected areas. This emerging disease, caused by the exotic pathogen Phytophthora ramorum (S. Werres, A.W.A.M. de Cock), has had especially severe effects on tanoak ( Notholithocarpus densiflorus (Hook. & Arn.) Manos, Cannon & S.H. Oh), a broadleaf evergreen that is abundant in forests dominated by coast redwood ( Sequoia sempervirens (D.Don) Endl.). Tanoak, a valuable food source to numerous wildlife species, is unlikely to successfully regenerate in diseased areas, and thus, affected redwood forests are transitioning to a novel state. In this study, to predict which species might replace tanoak, we investigated regeneration patterns in heavily impacted stands in Marin County, California. Our main findings were as follows: (i) despite reductions in canopy cover, there is no evidence that any species other than tanoak has exhibited a regenerative response to tanoak mortality, (ii) the regeneration stratum was dominated by redwood and tanoak (other tree species were patchy and (or) scarce), and (iii) some severely affected areas lacked sufficient regeneration to fully re-occupy available growing space. Our results indicate that redwood is likely to initially re-occupy the majority of the ground relinquished by tanoak, but also provide evidence that longer-term trajectories are unresolved, and may be highly responsive to management interventions.

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Zamborsky, Radoslav, Miroslav Kilian, Maria Csobonyeiova, and Lubos Danisovic. "Regenerative Medicine in Orthopaedics and Trauma: Challenges, Regulation and Ethical Issues." Ortopedia Traumatologia Rehabilitacja 20, no. 3 (June 30, 2018): 173–80. http://dx.doi.org/10.5604/01.3001.0012.0764.

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The ability of stem cells to self-renew and differentiate into cell types of different lineages forms the basis of regenerative medicine, which focuses on repairing or regenerating damaged or diseased tissues. This has a huge potential to revolutionize medicine. It is anticipated that in future, stem cell therapy will be able to restore function in all major organs. Intensive research has been on-going to bring stem cell therapy from bench to bedside as it holds promise of widespread applications in different areas of medicine. This is also applicable to orthopaedics, where stem cell transplantation could benefit complications like spinal cord injury, critical bone defects, cartilage repair or degenerative disc disorders. Stem cell therapy has a potential to change the field of orthopaedics from surgical replacements and reconstructions to a field of regeneration and prevention. This article summarizes advances in stem cell applications in orthopaedics as well as discussing regulation and ethical issues related to the use of stem cells.

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Emerson, Chloe E., Helena C. Reinardy, Nicholas R. Bates, and Andrea G. Bodnar. "Ocean acidification impacts spine integrity but not regenerative capacity of spines and tube feet in adult sea urchins." Royal Society Open Science 4, no. 5 (May 2017): 170140. http://dx.doi.org/10.1098/rsos.170140.

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Increasing atmospheric carbon dioxide (CO 2 ) has resulted in a change in seawater chemistry and lowering of pH, referred to as ocean acidification. Understanding how different organisms and processes respond to ocean acidification is vital to predict how marine ecosystems will be altered under future scenarios of continued environmental change. Regenerative processes involving biomineralization in marine calcifiers such as sea urchins are predicted to be especially vulnerable. In this study, the effect of ocean acidification on regeneration of external appendages (spines and tube feet) was investigated in the sea urchin Lytechinus variegatus exposed to ambient (546 µatm), intermediate (1027 µatm) and high (1841 µatm) partial pressure of CO 2 ( p CO 2 ) for eight weeks. The rate of regeneration was maintained in spines and tube feet throughout two periods of amputation and regrowth under conditions of elevated p CO 2 . Increased expression of several biomineralization-related genes indicated molecular compensatory mechanisms; however, the structural integrity of both regenerating and homeostatic spines was compromised in high p CO 2 conditions. Indicators of physiological fitness (righting response, growth rate, coelomocyte concentration and composition) were not affected by increasing p CO 2 , but compromised spine integrity is likely to have negative consequences for defence capabilities and therefore survival of these ecologically and economically important organisms.

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Srikuea, Ratchakrit, and Muthita Hirunsai. "Effects of intramuscular administration of 1α,25(OH)2D3 during skeletal muscle regeneration on regenerative capacity, muscular fibrosis, and angiogenesis." Journal of Applied Physiology 120, no. 12 (June 15, 2016): 1381–93. http://dx.doi.org/10.1152/japplphysiol.01018.2015.

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The recent discovery of the vitamin D receptor (VDR) in regenerating muscle raises the question regarding the action of vitamin D3 on skeletal muscle regeneration. To investigate the action of vitamin D3 on this process, the tibialis anterior muscle of male C57BL/6 mice (10 wk of age) was injected with 1.2% BaCl2 to induce extensive muscle injury. The bioactive form of vitamin D3 [1α,25(OH)2D3] was administered daily via intramuscular injections during the regenerative phase (days 4-7 postinjury). Physiological and supraphysiological doses of 1α,25(OH)2D3 relative to 1 μg/kg muscle wet weight and mouse body weight were investigated. Muscle samples were collected on day 8 postinjury to examine proteins related to vitamin D3 metabolism (VDR, CYP24A1, and CYP27B1), satellite cell differentiation and regenerative muscle fiber formation [myogenin and embryonic myosin heavy chain (EbMHC)], protein synthesis signaling (Akt, p70 S6K1, 4E-BP1, and myostatin), fiber-type composition (fast and slow MHCs), fibrous formation (vimentin), and angiogenesis (CD31). Administration of 1α,25(OH)2D3 at physiological and supraphysiological doses enhanced VDR expression in regenerative muscle. Moreover, CYP24A1 and vimentin expression was increased, accompanying decreased myogenin and EbMHC expression at the supraphysiological dose. However, there was no change in CYP27B1, Akt, p70 S6K1, 4E-BP1, myostatin, fast and slow MHCs, or CD31 expression at any dose investigated. Taken together, administration of 1α,25(OH)2D3 at a supraphysiological dose decreased satellite cell differentiation, delayed regenerative muscle fiber formation, and increased muscular fibrosis. However, protein synthesis signaling, fiber-type composition, and angiogenesis were not affected by either 1α,25(OH)2D3 administration at a physiological or supraphysiological dose.

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Yuan, Wang, Gildas Diguet, Guo Xing Lin, and Jin Can Chen. "Performance Analysis of the Regenerative Brayton Refrigeration Cycle Using Gd_0.94Er_0.06 as the Working Substance." Advanced Materials Research 631-632 (January 2013): 318–21. http://dx.doi.org/10.4028/www.scientific.net/amr.631-632.318.

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Based on the experimental data of entropy change varying with temperature, the regenerative Brayton refrigeration cycle using Gd0.94Er0.06 as the working substance is set up for magnetic field changes with 0-1T and 0-2T. By using thermodynamic analysis method, some parameters such as the non-perfect regeneration, net cooling quantity, coefficient of performance (COP), and so on, are analyzed and calculated. The effects of temperature of the heat reservoir, regeneration and external magnetic field are also discussed. The results obtained in the present paper show that the refrigeration cycle operating in TC=T0, TH= T0+7K and 0-2T magnetic field change has not only maximum cooling quantity but also maximum COP in all the established magnetic refrigeration cycles, and can provide some new guide for the optimal design of real room-temperature magnetic refrigerators.

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De Coppi, Paolo, and T. C. Grikscheit. "Regenerative medicine: Is this the biggest change in surgery?" Seminars in Pediatric Surgery 23, no. 3 (June 2014): 103–5. http://dx.doi.org/10.1053/j.sempedsurg.2014.04.001.

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Klein, Robert N., Jim Doyle, and Bernard Siegel. "It's about change...regenerative medicine in the Obama era." Regenerative Medicine 4, no. 1 (January 2009): 27–32. http://dx.doi.org/10.2217/17460751.4.1.27.

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Milne, Christopher-Paul, and Kenneth I. Kaitin. "Challenge and Change at the Forefront of Regenerative Medicine." Clinical Therapeutics 40, no. 7 (July 2018): 1056–59. http://dx.doi.org/10.1016/j.clinthera.2018.06.008.

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Langer, Ayelet C. "Milton’s Aristotelian Transformations in the Representation of Regenerative Change." Modern Philology 118, no. 3 (February 1, 2021): 390–408. http://dx.doi.org/10.1086/712386.

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Wang, Wei, Chi-Kuo Hu, An Zeng, Dana Alegre, Deqing Hu, Kirsten Gotting, Augusto Ortega Granillo, et al. "Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates." Science 369, no. 6508 (September 3, 2020): eaaz3090. http://dx.doi.org/10.1126/science.aaz3090.

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Vertebrates vary in their ability to regenerate, and the genetic mechanisms underlying such disparity remain elusive. Comparative epigenomic profiling and single-cell sequencing of two related teleost fish uncovered species-specific and evolutionarily conserved genomic responses to regeneration. The conserved response revealed several regeneration-responsive enhancers (RREs), including an element upstream to inhibin beta A (inhba), a known effector of vertebrate regeneration. This element activated expression in regenerating transgenic fish, and its genomic deletion perturbed caudal fin regeneration and abrogated cardiac regeneration altogether. The enhancer is present in mammals, shares functionally essential activator protein 1 (AP-1)–binding motifs, and responds to injury, but it cannot rescue regeneration in fish. This work suggests that changes in AP-1–enriched RREs are likely a crucial source of loss of regenerative capacities in vertebrates.

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Thomson, Giles, and Peter Newman. "Cities and the Anthropocene: Urban governance for the new era of regenerative cities." Urban Studies 57, no. 7 (September 12, 2018): 1502–19. http://dx.doi.org/10.1177/0042098018779769.

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The emerging ‘grand challenges’ of climate change, resource scarcity and population growth present a risk nexus to cities in the Anthropocene. This article discusses the potential that rapid urbanisation presents to help mitigate these risks through large-scale transitions if future urban development is delivered using evidence-based policies that promote regenerative urban outcomes (e.g. decarbonising energy, recycling water and waste, generating local food, integrating biodiversity). Observations from an Australian case study are used to describe urban governance approaches capable of supporting regenerative urbanism. The regenerative urbanism concept is associated with macro-scale urban and transport planning that shapes different urban fabrics (walking, transit, automobile), as the underlying infrastructure of each fabric exhibits a different performance, with automobile fabric being the least regenerative. Supporting urban systems based upon regenerative design principles at different scales (macro, meso and micro) can deliver deep and dramatic outcomes for not just reducing the impact of the grand challenges but turning them into regenerative change. In combination, these approaches form the cornerstone of regenerative cities that can address the grand challenges of the Anthropocene, while simultaneously improving livability and urban productivity to foster human flourishing.

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Yoshimura, Kotaro, and Kiyonori Harii. "A Regenerative Change during Muscle Adaptation to Denervation in Rats." Journal of Surgical Research 81, no. 2 (February 1999): 139–46. http://dx.doi.org/10.1006/jsre.1998.5504.

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Yoshimura, Kotaro, and Kiyonori Harii. "A Regenerative Change during Muscle Adaptation to Denervation in Rats." Journal of Surgical Research 83, no. 1 (May 1999): 82. http://dx.doi.org/10.1006/jsre.1999.5645.

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Darkwa, K. "Evaluation of regenerative phase change drywalls: low-energy buildings application." International Journal of Energy Research 23, no. 14 (November 1999): 1205–12. http://dx.doi.org/10.1002/(sici)1099-114x(199911)23:14<1205::aid-er575>3.0.co;2-h.

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Kuroda, Shinji. "Attempt to regenerate tooth extraction cavity by three dimensional culture construct using buccal adipose-derived stem cells." Impact 2019, no. 8 (November 26, 2019): 12–14. http://dx.doi.org/10.21820/23987073.2019.8.12.

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Bones are the scaffolding of our bodies, without which we have no structure or anchoring points for muscles, tendons and teeth. As strong as they are though, bones often break or suffer from diseases like cancer, osteoporosis or genetic disorders which impede their proper development. While a broken bone can heal and partially regenerate, in the cases of severe bone defects or injuries doctors have long relied on artificial replacements and various other artificial fixes due to the limitations in bone regeneration. Everything from joint replacements to dental implants has relied on synthetic materials anchored to existing bone. This approach is useful and helps many people but has its limitations. Regenerative dental expert Dr Shinji Kuroda, Junior Associate Professor in the Department of Oral Implantology and Regenerative Dental Medicine at the Tokyo Medical and Dental University, explains that in some cases, infection issues arise from placing foreign objects in the body, and in the case of dental implants there is often not enough bone to anchor implants to. For example, following a tooth extraction the bone, within which the tooth sockets sit, the alveolar ridge, experiences a reduction. 'This reduction is a physiological process and results in reduced stability and aesthetic quality of the dental implants used to replace the extracted tooth,' observes Kuroda. 'Despite numerous strategies to prevent this physiological change, such as immediate implant placement into the fresh extraction site, definitive treatment strategies have not yet been discovered to mitigate this bone loss.' In situations like this or in the case of congenital defects that lead to severe bone damage or loss, the best way forward lies in the promise of regenerative medicine techniques to regrow bone.

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Krupnick, Alexander S., Jianliang Zhu, Taitan Nguyen, Daniel Kreisel, Keki R. Balsara, Edward B. Lankford, Charles C. Clark, Sanford Levine, Hansell H. Stedman, and Joseph B. Shrager. "Inspiratory loading does not accelerate dystrophy inmdx mouse diaphragm: implications for regenerative therapy." Journal of Applied Physiology 94, no. 2 (February 1, 2003): 411–19. http://dx.doi.org/10.1152/japplphysiol.00689.2002.

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Since the finding that the mdx mouse diaphragm, in contrast to limb muscles, undergoes progressive degeneration analogous to that seen in Duchenne muscular dystrophy, the relationship between the workload on a muscle and the pathogenesis of dystrophy has remained controversial. We increased the work performed by the mdx mouse diaphragm in vivo by tracheal banding and evaluated the progression of dystrophic changes in that muscle. Despite the establishment of dramatically increased respiratory workload and accelerated myofiber damage documented by Evans blue dye, no change in the pace of progression of dystrophy was seen in banded animals vs. unbanded, sham-operated controls. At the completion of the study, more centrally nucleated fibers were evident in the diaphragms of banded mdx mice than in sham-operated mdx controls, indicating that myofiber regeneration increases to meet the demands of the work-induced damage. These data suggest that there is untapped regenerative capacity in dystrophin-deficient muscle and validates experimental efforts aimed at augmenting regeneration within skeletal muscle as a therapeutic strategy in the treatment of dystrophinopathies.

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Greene, D. F., and E. A. Johnson. "Modelling recruitment of Populus tremuloides, Pinus banksiana, and Picea mariana following fire in the mixedwood boreal forest." Canadian Journal of Forest Research 29, no. 4 (April 1, 1999): 462–73. http://dx.doi.org/10.1139/x98-211.

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We examined the relationship between the post-fire regeneration density of Populus tremuloides Michx., Pinus banksiana Lamb., and Picea mariana (Mill.) BSP and their pre-fire basal area density at the spatial scale of 70 m (the width of the stands studied) in four fires in central Saskatchewan and one in Quebec. For these three species with mechanisms for in situ reproduction, there were highly significant relationships between regeneration density and pre-fire basal area density (basal area per area). Given equal source basal area densities, Populus tremuloides has an advantage, relative to the other two species, in initial regeneration densities, but the advantage is not great because the asexual stems thin rapidly. The overriding conclusion is that, for these three species, there is little change in species composition following fire. Simple predictive equations performed reasonably well for Pinus banksiana and Picea mariana: FD = 806BD0.95 and FD = 593BD0.86, where FD is regenerative stem density (no./m2), and BD is basal area density (m2/m2). For asexual reproduction by Populus tremuloides, the thinning begins immediately following fire, and the regeneration model was FD = 11 600BD0.79(t + 1)-1.64, where t is years since fire.

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Cole, Raymond J. "Navigating Climate Change: Rethinking the Role of Buildings." Sustainability 12, no. 22 (November 16, 2020): 9527. http://dx.doi.org/10.3390/su12229527.

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This paper focuses on the design of buildings as part of society’s response to the climate crisis in the aftermath of the COVID-19 pandemic. It draws on a broad literature to address two interrelated goals—first, to align regenerative development and design with the necessary bottom-up adaptation strategies and human agency, and second, to identify new, broader possible roles of buildings and responsibilities of design professionals. This required a comparison of current green building and emerging regenerative approaches and identifying the relevant characteristics of top-down and bottom-up mechanisms. The paper accepts that adaptation to climate change will, to a large extent, depend on people’s day-to-day actions in the places they live, and argues that the built environment will have to be infused with the capability to enable inhabitants’ greater agency. Viewing buildings as playing a connective role in the existing urban fabric seriously challenges the primacy of the individual building as the focus of environmental strategies. The roles of building design professionals will likely expand to include mediating between top-down imposed government controls and increasing bottom-up neighborhood-scale social activism.

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NEZEVAK, Vladislav. "ASSESSMENT OF ENERGY ACCUMULATION SYSTEM IMPACT UPON VOLTAGE LEVEL ON BUSES OF ACTIVE POINT OF DC SECTIONING." Bulletin of Bryansk state technical university 2021, no. 8 (August 9, 2021): 46–60. http://dx.doi.org/10.30987/1999-8775-2021-8-46-60.

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The work purpose is to estimate and investigate processes of the regenerative braking impact upon a voltage level on object buses of the system of traction power supply at electricity storage systems. In the investigation there are used methods of imitation modeling and analytical ones allowing the fulfillment of calculations for different conditions of the electric traction load formation within the limits of inter-substation areas under consideration. The work novelty consists in the approach to the estimation of the working mode impact of electricity storage systems upon the voltage level on buses of the objects of traction power supply under conditions of regenerative braking and charge characteristics changes. In the course of the investigation there are obtained the following results: the work cyclicity change estimation of a storage system is carried out; the dependence of a charge depth change upon rated power consumption is defined; charge characteristics for conditions of charge predominance in the diagram are calculated; the character of voltage changes on object buses of the system of traction power supply is defined; the necessity of charge characteristic adaptation depending on conditions of regenerative braking use is defined. The regenerative braking use makes an impact upon charge characteristics formed from the condition of charge predominance in the diagram of a charge degree at the rated interval and allows increasing currents of the second stage of the charge characteristics allowing the decrease voltage loss at charge realization caused by adjacent traction substations at the first stage.

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Asmussen, Søren, Reuven Y. Rubinstein, and Chia-Li Wang. "Regenerative rare events simulation via likelihood ratios." Journal of Applied Probability 31, no. 3 (September 1994): 797–815. http://dx.doi.org/10.2307/3215157.

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In this paper we obtain some new theoretical and numerial results on estimation of small steady-state probabilities in regenerative queueing models by using the likelihood ratio (score function) method, which is based on a change of the probability measure. For simple GI/G/1 queues, this amounts to simulating the regenerative cycles by a suitable change of the interarrival and service time distribution, typically corresponding to a reference traffic intensity ρ0 which is < 1 but larger than the given one ρ. For the M/M/1 queue, the resulting gain of efficiency is calculated explicitly and shown to be considerable. Simulation results are presented indicating that similar conclusions hold for gradient estimates and in more general queueing models like queueing networks.

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Asmussen, Søren, Reuven Y. Rubinstein, and Chia-Li Wang. "Regenerative rare events simulation via likelihood ratios." Journal of Applied Probability 31, no. 03 (September 1994): 797–815. http://dx.doi.org/10.1017/s0021900200045356.

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In this paper we obtain some new theoretical and numerial results on estimation of small steady-state probabilities in regenerative queueing models by using the likelihood ratio (score function) method, which is based on a change of the probability measure. For simple GI/G/1 queues, this amounts to simulating the regenerative cycles by a suitable change of the interarrival and service time distribution, typically corresponding to a reference traffic intensity ρ 0 which is < 1 but larger than the given one ρ. For the M/M/1 queue, the resulting gain of efficiency is calculated explicitly and shown to be considerable. Simulation results are presented indicating that similar conclusions hold for gradient estimates and in more general queueing models like queueing networks.

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Wang, Limin, Chao Wang, Yalong Guo, Ying Wu, Wengang Bai, and Defu Che. "Novel rotary regenerative heat exchanger using cascaded phase change material capsules." Applied Thermal Engineering 188 (April 2021): 116619. http://dx.doi.org/10.1016/j.applthermaleng.2021.116619.

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Zhang, Shi Tong, Liang Chu, Liang Yao, Yi Yang, and Hua Zhang. "The Design of Regenerative Braking System with a Pedal Emulator." Advanced Materials Research 694-697 (May 2013): 1602–7. http://dx.doi.org/10.4028/www.scientific.net/amr.694-697.1602.

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According to the regenerative braking system(RBS) with a pedal emulator as well as the control strategy. Design a hardware test platform of power regenerative system and the scheme of software experiment. Aim at the control strategy, braking safety and braking feeling of RBS with a braking pedal emulator is confirmed via hardware in loop (HIL) test. A high regenerative rate is obtained. From the result of simulation, the pedal force line from RBS with a pedal emulator is between the envelope curve of the pedal force from conventional vehicle. Actual wheel cylinder pressure can follow the change of target pressure very well. The regenerative braking rate reaches 53%.

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Nejad, J., A. Riasi, and A. Nourbakhsh. "Efficiency improvement of regenerative pump using blade profile modification: Experimental study." Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering 233, no. 3 (March 22, 2018): 448–55. http://dx.doi.org/10.1177/0954408918763554.

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Regenerative flow pump is a kind of turbomachine with the ability to generate high heads at relatively low flow rates. Despite having low hydraulic efficiency, regenerative pumps have found many applications in industries due to their simplicity, compact size, low manufacturing costs, and low specific speed. In this paper, an experimental study has been carried out to investigate the influence of impeller blade change on the performance of regenerative pump. To this end, the straight radial blades were changed to curved blades with the same inlet/outlet angles. Three forward curved blade impellers as well as straight radial blade impeller were designed and manufactured. Since the regenerative pump comply with the affinity laws, the results of experimental tests were expressed in nondimensional coefficients. The results showed that by increasing the blade angle to 10°, the efficiency increased and at higher blade angles of 30° and 50°, the efficiency decreased for all flow conditions. The best angle was obtained about 15° by curve fitting to the experimental data at the design flow coefficient.

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Wang, Ruochen, Yanshu Ding, Qing Ye, Renkai Ding, and Jingang Qian. "Research into the Effect of Supercapacitor Terminal Voltage on Regenerative Suspension Energy-Regeneration and Dynamic Performance." Shock and Vibration 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/6542015.

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To study the effect of supercapacitor initial terminal voltage on the regenerative and semiactive suspension energy-regeneration and dynamic performance, firstly, the relationship between supercapacitor terminal voltage and linear motor electromagnetic damping force and that between supercapacitor terminal voltage and recycled energy by the supercapacitor in one single switching period were both analyzed. The result shows that the linear motor electromagnetic damping force is irrelevant to the supercapacitor terminal voltage, and the recycled energy by the supercapacitor reaches the maximum when initial terminal voltage of the supercapacitor equals output terminal voltage of the linear motor. Then, performances of system dynamics and energy-regeneration were studied as the supercapacitor initial terminal voltage varied in situations of B level and C level road. The result showed that recycled energy by the supercapacitor increased at first and then decreased while the dynamic performance had no obvious change. On the basis of previous study, a mode-switching control strategy of supercapacitor for the regenerative and semiactive suspension system was proposed, and the mode-switching rule was built. According to simulation and experiment results, the system energy-regeneration efficiency can be increased by utilizing the control strategy without influencing suspension dynamic performance, which is highly valuable to practical engineering.

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Tian, Zhong Jun, Shi Ping Jin, Yu Ming Liang, Kui Tian, Zhen Biao Hao, and Xue Jiao Luo. "The Experimental Investigation on the Internal Temperature Field of Regenerative Burners." Applied Mechanics and Materials 291-294 (February 2013): 1723–27. http://dx.doi.org/10.4028/www.scientific.net/amm.291-294.1723.

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The application of regenerative combustion technology to industry burners has been a huge success. This paper presents an experimental study on the change of the temperature field and the concentration of NO in the flue gas in an industrial furnace. The result showed that the concentration of NO increased with the rise of temperature. For the reversing time of 20s, 40s, 60s, and 80s, the temperature of each point changed in accordance with similar rules, but the temperature of the former three measuring points did not obviously change. The heat transfer occured mainly in the last two layers of the regenerative cells, and the utilization of all the regenerators was only 40 percent. The heating curve of the sixth measuring points was significantly different from the cooling one. With the increase of the reversing time, the flue gas and the air temperature variation also increased.

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Hu, Jianjun, Zihan Guo, Hang Peng, and Dawei Zheng. "Research on regenerative braking control strategy of plug-in hybrid electric vehicle considering CVT ratio rate of change." Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering 232, no. 14 (November 15, 2017): 1931–43. http://dx.doi.org/10.1177/0954407017735681.

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At present, the regenerative braking control strategies for hybrid electric vehicles equipped with continuously variable transmission (CVT) mainly focus on improving the regenerative braking efficiency. But the influence of dynamic change of the CVT ratio is not considered with regard to the intended braking effect. For a CVT ratio control strategy based on steady-state optimal efficiency, the performance of motor-only braking and engine/motor combined braking modes are analyzed. The analysis of these modes shows that actual braking strength deviates from that required during the dynamic braking process. After analyzing the dynamic characteristics of a transmission system, a CVT ratio control strategy based on the limitations of the ratio rate of change is proposed, with the use of a discrete exhaustive optimization method. The simulation results show that, under a variety of braking conditions, the proposed regenerative braking control strategy can make the actual braking strength follow the requirements and recover more braking energy.

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Chen, Lingen, Huijun Feng, and Yanlin Ge. "Power and Efficiency Optimization for Open Combined Regenerative Brayton and Inverse Brayton Cycles with Regeneration before the Inverse Cycle." Entropy 22, no. 6 (June 17, 2020): 677. http://dx.doi.org/10.3390/e22060677.

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A theoretical model of an open combined cycle is researched in this paper. In this combined cycle, an inverse Brayton cycle is introduced into regenerative Brayton cycle by resorting to finite-time thermodynamics. The constraints of flow pressure drop and plant size are taken into account. Thirteen kinds of flow resistances in the cycle are calculated. On the one hand, four isentropic efficiencies are used to evaluate the friction losses in the blades and vanes. On the other hand, nine kinds of flow resistances are caused by the cross-section variances of flowing channels, which exist at the entrance of top cycle compressor (TCC), the entrance and exit of regenerator, the entrance and exit of combustion chamber, the exit of top cycle turbine, the exit of bottom cycle turbine, the entrance of heat exchanger, as well as the entrance of bottom cycle compressor (BCC). To analyze the thermodynamic indexes of power output, efficiency along with other coefficients, the analytical formulae of these indexes related to thirteen kinds of pressure drop losses are yielded. The thermodynamic performances are optimized by varying the cycle parameters. The numerical results reveal that the power output presents a maximal value when the air flow rate and entrance pressure of BCC change. In addition, the power output gets its double maximal value when the pressure ratio of TCC further changes. In the premise of constant flow rate of working fuel and invariant power plant size, the thermodynamic indexes can be optimized further when the flow areas of the components change. The effect of regenerator on thermal efficiency is further analyzed in detail. It is reported that better thermal efficiency can be procured by introducing the regenerator into the combined cycle in contrast with the counterpart without the regenerator as the cycle parameters change in the critical ranges.

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Beresescu, Gabriela Felicia, Alina Ormenisan, Melinda Szekely, Monica Monea, and Adriana Monea. "Clinical Outcomes after Regenerative Periodontal Therapy with Emdogain." Acta Medica Marisiensis 63, no. 3 (September 1, 2017): 136–39. http://dx.doi.org/10.1515/amma-2017-0015.

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Abstract Objective: Regeneration is defined as a reconstruction of a lost part of the body in such a way that the structure and function of the lost tissue are completely restored. The aim of this study is to compare the clinical outcomes of intrabony defects treatment using regenerative periodontal therapy with enamel matrix proteins (Emdogain, EMD) with a control group. Methods: Ten patients with chronic periodontitis were included in this randomized, controlled clinical study. Two groups received conservative periodontal therapy. In the test group, different teeth received regenerative treatment with EMD. In the control group teeth received solely conservative periodontal therapy. Pocket depth probing (PD) and bone reduction (based on X rays) were registered at baseline and after eight months in both groups. In the control group Results: Both groups showed a significant reduction of PD. The teeth treated with EMD showed a significant attachment gain. Within the test group, the radiographic examination of the teeth treated with EMD showed no significant change, whereas the teeth in the control group showed significant bone reduction. Conclusions: Intrabony defects in teeth treaded with EMD exhibit a substantially higher gain in clinical attachment and defect filling. The use of EMD in dental practice can prevent further bone loss.

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Albrecht, J. H., J. S. Hoffman, B. T. Kren, and C. J. Steer. "Cyclin and cyclin-dependent kinase 1 mRNA expression in models of regenerating liver and human liver diseases." American Journal of Physiology-Gastrointestinal and Liver Physiology 265, no. 5 (November 1, 1993): G857—G864. http://dx.doi.org/10.1152/ajpgi.1993.265.5.g857.

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There is compelling evidence that the eukaryotic cell cycle is controlled by a family of proteins called cyclins, which complex with cyclin-dependent kinases (CDK) to modulate key events during cell division. We have examined the regulation of these genes in models of experimental liver regeneration and their expression in human liver diseases. Seventy percent partial hepatectomy (PH) was performed on rats and normal BALB/c and athymic nude mice to determine patterns of cyclin and CDK1 mRNA expression. It has been previously shown by [3H]thymidine incorporation that athymic nude mice manifest impaired regeneration after PH. Our results demonstrate a sequential pattern of cyclin and CDK1 transcript expression in each of the models. Cyclin D1 was the most abundant mRNA steady-state transcript in the regenerating livers. CDK1 and cyclins associated with later stages of the cell cycle showed delayed and diminished expression in nude mice compared with normals. Nuclear run-off assays performed at key time points post-PH revealed little change in transcription rates, suggesting that steady-state mRNA expression of the cyclin genes is regulated primarily by posttranscriptional events. Human liver tissue from various acute and chronic hepatic diseases showed increased expression of cyclins A and D1. We conclude that the regenerating liver post-PH offers an excellent in vivo model for studying cyclin and CDK gene expression. Impaired regeneration in the nude mouse is associated with altered cyclin and CDK1 mRNA transcript expression. Furthermore, cyclins may eventually provide clinically relevant molecular markers of regenerative activity in human liver diseases.

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Téllez, Noèlia, Marina Vilaseca, Yasmina Martí, Arturo Pla, and Eduard Montanya. "β-Cell dedifferentiation, reduced duct cell plasticity, and impaired β-cell mass regeneration in middle-aged rats." American Journal of Physiology-Endocrinology and Metabolism 311, no. 3 (September 1, 2016): E554—E563. http://dx.doi.org/10.1152/ajpendo.00502.2015.

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Limitations in β-cell regeneration potential in middle-aged animals could contribute to the increased risk to develop diabetes associated with aging. We investigated β-cell regeneration of middle-aged Wistar rats in response to two different regenerative stimuli: partial pancreatectomy (Px + V) and gastrin administration (Px + G). Pancreatic remnants were analyzed 3 and 14 days after surgery. β-Cell mass increased in young animals after Px and was further increased after gastrin treatment. In contrast, β-cell mass did not change after Px or after gastrin treatment in middle-aged rats. β-Cell replication and individual β-cell size were similarly increased after Px in young and middle-aged animals, and β-cell apoptosis was not modified. Nuclear immunolocalization of neurog3 or nkx6.1 in regenerative duct cells, markers of duct cell plasticity, was increased in young but not in middle-aged Px rats. The pancreatic progenitor-associated transcription factors neurog3 and sox9 were upregulated in islet β-cells of middle-aged rats and further increased after Px. The percentage of chromogranin A+/hormone islet cells was significantly increased in the pancreases of middle-aged Px rats. In summary, the potential for compensatory β-cell hyperplasia and hypertrophy was retained in middle-aged rats, but β-cell dedifferentiation and impaired duct cell plasticity limited β-cell regeneration.

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Mahla, Ranjeet Singh. "Stem Cells Applications in Regenerative Medicine and Disease Therapeutics." International Journal of Cell Biology 2016 (2016): 1–24. http://dx.doi.org/10.1155/2016/6940283.

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Regenerative medicine, the most recent and emerging branch of medical science, deals with functional restoration of tissues or organs for the patient suffering from severe injuries or chronic disease. The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by conventional medicines. The indefinite self-renewal and potential to differentiate into other types of cells represent stem cells as frontiers of regenerative medicine. The transdifferentiating potential of stem cells varies with source and according to that regenerative applications also change. Advancements in gene editing and tissue engineering technology have endorsed the ex vivo remodelling of stem cells grown into 3D organoids and tissue structures for personalized applications. This review outlines the most recent advancement in transplantation and tissue engineering technologies of ESCs, TSPSCs, MSCs, UCSCs, BMSCs, and iPSCs in regenerative medicine. Additionally, this review also discusses stem cells regenerative application in wildlife conservation.

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Williams, Katie. "Regenerative design as a force for change: thoughtful, optimistic and evolving ideas." Building Research & Information 40, no. 3 (June 2012): 361–64. http://dx.doi.org/10.1080/09613218.2012.662389.

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Zapuskalov, I. V., O. I. Krivosheina, and N. A. Levchenko. "Inflammatory regenerative processes dynamics with corneal ulcer against the background of usage of blood autologous mononuclear leukocyte." Bulletin of Siberian Medicine 10, no. 1 (February 28, 2011): 38–42. http://dx.doi.org/10.20538/1682-0363-2011-1-38-42.

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In the experiment in vivo the mechanisms of the development of inflammatory regenerative processes with corneal ulcer against the background of the instillations of blood autologous mononuclear leukocyte and traditional pharmacotherapy are studied. It is determined that against the background of the use of blood autologous mononuclear leukocyte the duration and the intensity of inflammation reduce and the clearance of ulcer defect from necrotic mass accelerates. The instillations of blood autologous mononuclear leukocyte against the background of traditional pharmacotherapy of experimental corneal ulcer stimulate fast change of cell phases in the inflammation center and activate the process of regeneration of damaged cornea structures.

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Zhang, Churen, Haidong Zhang, Zhaoguo Yue, Lili Miao, Ye Han, Kaining Liu, and Jianxia Hou. "Modified minimally invasive surgical technique plus Bio-Oss Collagen for regenerative therapy of isolated interdental intrabony defects: study protocol for a randomised controlled trial." BMJ Open 10, no. 12 (December 2020): e040046. http://dx.doi.org/10.1136/bmjopen-2020-040046.

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IntroductionPeriodontal regeneration surgery has been widely used to deal with intrabony defects. Modified minimally invasive surgical technique (M-MIST) is designed to deal with isolated interdental intrabony defects, and has achieved satisfactory periodontal regenerative effect. Bio-Oss Collagen, as a bioactive material, has been applied for periodontal regeneration. It is similar to human cancellous bone, with the ability to promote bone formation; furthermore, it has exceptional plasticity and spatial stability. The combination of different materials and techniques has become a research hotspot in recent years. By combining the superiority of regeneration technology and materials, better regenerative effect can be achieved. This study will search for differences between M-MIST combined with Bio-Oss Collagen, and M-MIST alone in regeneration therapy for intrabony defects.Methods and analysisThe present research is designed as a two-group parallel randomised controlled trial. The total number of patients is 40. The patients will be randomly assigned to two groups, with 20 participants in each group, for further periodontal regenerative surgery. Test group: M-MIST plus Bio-Oss Collagen. Control group: M-MIST. After 12 months, the measurement indices will be recorded; these will include clinical attachment gain and radiographical intrabony defect depth change as the primary results, and secondary outcomes of full-mouth plaque scores, probing depth, full-mouth bleeding scores, gingival recession, mobility, gingival papilla height and Visual Analogue Scale. The paired samples t-test will be applied to detect any difference between baseline and 1-year registrations. A general linear model will be performed to study the relationship between the secondary and the primary outcome.Ethics and disseminationThe present research has received approval from the Ethics Committee of Peking University School and Hospital of Stomatology (PKUSSIRB-202053002). Data of the present research will be registered with the International Clinical Trials Registry Platform. Additionally, we will disseminate the results through scientific dental journals.Trial registration numberChiCTR-2000030851.Protocol versionProtocol Version 4, 14 July 2020.

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Su, Shan He, Zhi Chao Xu, Guo Xing Lin, Gildas Diguet, and Jin Can Chen. "Thermodynamic Performance Characteristics of a Regenerative Brayton Refrigeration Cycle Using Gd_0.45Tb_0.55 and Gd as the Working Substance." Advanced Materials Research 750-752 (August 2013): 1016–19. http://dx.doi.org/10.4028/www.scientific.net/amr.750-752.1016.

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Based on experimental characteristics of the iso-field heat capacity of the working substances Gd0.45Tb0.55and Gd, the magnetic entropy change with temperature is calculated. The regenerative Brayton refrigeration cycles employing these materials as the working substances are established. By means of thermodynamic analysis and numerical calculation, the effects of the non-perfect regeneration on the performance characteristics of the refrigeration cycles are revealed. Furthermore, the cyclic performances employing Gd0.45Tb0.55and Gd as the working substances are evaluated and compared. The results obtained may provide some useful information for the optimal design of the room temperature magnetic refrigerators.

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Shastri, Sunita, Marla C. Dubinsky, F. Fred Poordad, Eric A. Vasiliauskas, and Stephen A. Geller. "Early Nodular Hyperplasia of the Liver Occurring With Inflammatory Bowel Diseases in Association With Thioguanine Therapy." Archives of Pathology & Laboratory Medicine 128, no. 1 (January 1, 2004): 49–53. http://dx.doi.org/10.5858/2004-128-49-enhotl.

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Abstract Context.—Nodular hyperplasia (also referred to as nodular regenerative hyperplasia and nodular regenerative hyperplasia of the liver) is a sequel to therapy with thioguanine in patients with hematologic malignancies. Recently, 6-thioguanine has been used to treat patients with inflammatory bowel disease who have been resistant to other forms of therapy. Objective.—To study liver biopsies from 3 patients with inflammatory bowel disease who had received thioguanine for more than a year, and who had elevated serum liver enzyme values and underwent percutaneous liver biopsy. Design.—Percutaneous liver biopsies and histologic examinations were performed, including staining with the reticulin silver impregnation method. Results.—All 3 patients had foci of nodular regenerative hyperplasia, which was best seen with the reticulin silver impregnation method. Conclusions.—Thioguanine-treated inflammatory bowel disease patients are at risk for the development of nodular hyperplasia. Reticulin-stained histologic sections are necessary to recognize this change. Further studies are needed to determine the frequency and significance of this change.

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Zhang, Xiao Guang, Qiu Ping Ren, and Hong Du. "The Study of Stability of Time-Delay Systems in Milling." Applied Mechanics and Materials 633-634 (September 2014): 751–54. http://dx.doi.org/10.4028/www.scientific.net/amm.633-634.751.

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The effect on the stability of the analysis of time lag effect of the milling system，Reveals the root cause of the milling type regenerative chatter occurs，Milling type regenerative chatter is derived from the time-delay feedback within the system，Application of routh criterion and Fourier analysis of chatter in milling system before and after the change of rigidity and damping system, it is concluded that the limit cutting depth.

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Hawkins, Ashley E., and Terry W. Henkel. "Native forest pathogens facilitate persistence of Douglas-fir in old-growth forests of northwestern California." Canadian Journal of Forest Research 41, no. 6 (June 2011): 1256–66. http://dx.doi.org/10.1139/x11-053.

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Forest pathogens and insects can accelerate tree mortality, increase stand structural heterogeneity, and alter tree community composition. In northern California, the canopy trees Abies concolor var. lowiana (Gord. & Glend.) Lemmon (white fir) and Pseudotsuga menziesii var. menziesii (Mirbel) Franco (Douglas-fir) co-occur but vary in shade tolerance and regenerative abilities following disturbance. Field observations suggested that mortality and turnover of white fir exceeded that of Douglas-fir and that native pathogens may be important drivers in the absence of fire. Pathogens and bark beetles were sampled in old-growth white fir – Douglas-fir stands in northwestern California to assess their contribution to tree mortality, gap formation, and regeneration. We determined abundances and size class distributions of canopy trees, presence of pathogens and bark beetles, and causes of tree mortality. We sampled canopy gaps and closed-canopy forests for overstory species composition, cause of mortality of gap-maker trees, and regeneration of white fir and Douglas-fir. Root-rot fungi accounted for significantly higher mortality and gap formation in white fir than in Douglas-fir. Relative seedling–sapling density of Douglas-fir was higher in pathogen-induced canopy gaps than in closed-canopy forest. In the absence of fire, native forest pathogens enable regeneration and persistence of Douglas-fir by enhancing mortality of white fir, resulting in canopy gap formation.

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Shen, Han, Ying Wang, Zhiwei Zhang, Junjie Yang, Shijun Hu, and Zhenya Shen. "Mesenchymal Stem Cells for Cardiac Regenerative Therapy: Optimization of Cell Differentiation Strategy." Stem Cells International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/524756.

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With the high mortality rate, coronary heart disease (CHD) has currently become a major life-threatening disease. The main pathological change of myocardial infarction (MI) is the induction of myocardial necrosis in infarction area which finally causes heart failure. Conventional treatments cannot regenerate the functional cell efficiently. Recent researches suggest that mesenchymal stem cells (MSCs) are able to differentiate into multiple lineages, including cardiomyocyte-like cells in vitro and in vivo, and they have been used for the treatment of MI to repair the injured myocardium and improve cardiac function. In this review, we will focus on the recent progress on MSCs derived cardiomyocytes for cardiac regeneration after MI.

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Journal articles on the topic 'Regenerative change'

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