Academic literature on the topic 'Regeneration technology'

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Journal articles on the topic "Regeneration technology"

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Zhang, Haitao, Ying Wang, Zuoqiang Liu, and Quansheng Sun. "Study on Mechanical Behavior of Aging Asphalt Based on Composite Regeneration and Modification." Advances in Materials Science and Engineering 2020 (March 16, 2020): 1–11. http://dx.doi.org/10.1155/2020/1325048.

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Although the aging asphalt and its regeneration were researched by many researchers, the poor low-temperature performance of regenerating asphalt has still not been solved yet. In this project, the composite technology of regeneration and modification will be used to solve the problem mentioned above. Through the investigation and analysis on the composite mechanism of regeneration and modification for aging asphalt, the objective of the project attempts to explore a method for the synchronized recovery of high- and low-temperature performance of aging asphalt. The research results show that the single regenerating technology cannot fully recover the low-temperature performance of aging asphalt, and the composite technology of regeneration and modification can make the performance of aging asphalt recovery well. The indexes of aging asphalt after composite regeneration and modification have been recovered, which are better than the indexes of 90# asphalt (25°C penetration is 80–100/0.1 mm) and close with the indexes of styrene-butadiene-styrene (SBS) modified asphalt. The project has demonstrated that the composite technology of regeneration and modification can make the high- and low-temperature performance of aging asphalt recovery well. The research results can obtain better economic and social benefits.
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Li, Junxiao, Wei Fu, and Xiaobo Yin. "Finite Element Simulation and Construction Technology Research of Cement-Emulsified Asphalt Cold Recycling System." MATEC Web of Conferences 238 (2018): 05010. http://dx.doi.org/10.1051/matecconf/201823805010.

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The force model of pavement structure is established. In order to investigate the force on pavement when the ratio and thickness of cold recycled pavement vary, three concrete pavement structures, material parameters and vehicle load parameters are designed. By finite element analysis, type 2 pavement structure make the cold-regenerative pavement structure anti-XY surface shear stress, anti-Z compressive stress and anti-Z deformation three aspects are kept in a reasonable range, and it is considered that the cold regenerative pavement structure type 2 is the best. Type 2 is specifically composed of 8 cm new asphalt surface layer +20 cm no stabilized soil regeneration base +20 cm stabilized soil regeneration base + original road soil base. The results of this paper can provide some reference for the actual design of emulsified asphalt cold regeneration construction process.
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Tabata, Yasuhiko. "A New Concept of Biomaterials to Induce Tissue Regeneration." Materials Science Forum 561-565 (October 2007): 1467–70. http://dx.doi.org/10.4028/www.scientific.net/msf.561-565.1467.

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A new therapeutic trial based on the self-healing potential of cells to naturally induce tissue regeneration, has been recently noted. To realize this regenerative medical therapy, it is highly required to efficiently combine cells with their local environment which basically allows cells to survive and biologically function in vivo through the essential interaction. Tissue engineering is a biomedical technology or methodology to create the local environment which promotes the proliferation and differentiation of cells to induce tissue regeneration. There are some cases where tissue regeneration can be induced only by supplying a cell scaffold of biomaterials. Drug delivery system (DDS) with biomaterials enhanced the in vivo biological activities of un-stable growth factor and gene for cell-induced tissue regeneration. The controlled release technology enabled growth factors to achieve the regeneration of various tissues experimentally and clinically. The DDS technology also augmented the biological functions of plasmid DNA and small interference RNA. The cells genetically engineered by the DDS gene system showed an enhanced therapeutic efficacy in cell-based tissue regeneration (cell-gene hybrid therapy). By making use of DDS technology, it is possible to suppress the deterioration and proceeding of chronic fibrotic diseases based on the self-healing potential inherently equipped in the living body. This paper emphasizes significance of biomaterials in tissue engineering for regenerative medical therapy.
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IEDA, Masaki. "Heart regeneration using reprogramming technology." Proceedings of the Japan Academy, Series B 89, no. 3 (2013): 118–28. http://dx.doi.org/10.2183/pjab.89.118.

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Zhang, Yue, Congjie Ou, Bihong Lin, and Jincan Chen. "The Regenerative Criteria of an Irreversible Brayton Heat Engine and its General Optimum Performance Characteristics." Journal of Energy Resources Technology 128, no. 3 (October 22, 2005): 216–22. http://dx.doi.org/10.1115/1.2213272.

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An irreversible cycle model of the Brayton heat engine is established, in which the irreversibilities resulting from the internal dissipation of the working substance in the adiabatic compression and expansion processes and the finite-rate heat transfer in the regenerative and constant-pressure processes are taken into account. The power output and efficiency of the cycle are expressed as functions of temperatures of the working substance and the heat sources, heat transfer coefficients, pressure ratio, regenerator effectiveness, and total heat transfer area including the heat transfer areas of the regenerator and other heat exchangers. The regenerative criteria are given. The power output is optimized for a given efficiency. The general optimal performance characteristics of the cycle are revealed. The optimal performance of the Brayton heat engines with and without regeneration is compared quantitatively. The advantages of using the regenerator are expounded. Some important parameters of an irreversible regenerative Brayton heat engine, such as the temperatures of the working substance at different states, pressure ratio, maximum value of the pressure ratio, regenerator effectiveness and ratios of the various heat transfer areas to the total heat transfer area of the cycle, are further optimized. The optimal relations between these parameters and the efficiency of the cycle are presented by a set of characteristic curves for some assumed compression and expansion efficiencies. The results obtained may be helpful to the comprehensive understanding of the optimal performance of the Brayton heat engines with and without regeneration and play a theoretical instructive role for the optimal design of a regenerative Brayton heat engine.
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Suzuki-Horiuchi, Yoko, Henning Schmitz, Carlotta Barlassina, David Eccles, Martina Sinn, Claudia Ortmeier, Sören Moritz, and Luca Gentile. "Transcription Factors Active in the Anterior Blastema of Schmidtea mediterranea." Biomolecules 11, no. 12 (November 28, 2021): 1782. http://dx.doi.org/10.3390/biom11121782.

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Regeneration, the restoration of body parts after injury, is quite widespread in the animal kingdom. Species from virtually all Phyla possess regenerative abilities. Human beings, however, are poor regenerators. Yet, the progress of knowledge and technology in the fields of bioengineering, stem cells, and regenerative biology have fostered major advancements in regenerative medical treatments, which aim to regenerate tissues and organs and restore function. Human induced pluripotent stem cells can differentiate into any cell type of the body; however, the structural and cellular complexity of the human tissues, together with the inability of our adult body to control pluripotency, require a better mechanistic understanding. Planarians, with their capacity to regenerate lost body parts thanks to the presence of adult pluripotent stem cells could help providing such an understanding. In this paper, we used a top-down approach to shortlist blastema transcription factors (TFs) active during anterior regeneration. We found 44 TFs—31 of which are novel in planarian—that are expressed in the regenerating blastema. We analyzed the function of half of them and found that they play a role in the regeneration of anterior structures, like the anterior organizer, the positional instruction muscle cells, the brain, the photoreceptor, the intestine. Our findings revealed a glimpse of the complexity of the transcriptional network governing anterior regeneration in planarians, confirming that this animal model is the perfect playground to study in vivo how pluripotency copes with adulthood.
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Nigmatullin, V. R. "Technology of used motor oil regeneration." Chemistry and Technology of Fuels and Oils 48, no. 1 (March 2012): 29–32. http://dx.doi.org/10.1007/s10553-012-0332-5.

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Tani, Shoichiro, Hiroyuki Okada, Ung-il Chung, Shinsuke Ohba, and Hironori Hojo. "The Progress of Stem Cell Technology for Skeletal Regeneration." International Journal of Molecular Sciences 22, no. 3 (January 30, 2021): 1404. http://dx.doi.org/10.3390/ijms22031404.

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Skeletal disorders, such as osteoarthritis and bone fractures, are among the major conditions that can compromise the quality of daily life of elderly individuals. To treat them, regenerative therapies using skeletal cells have been an attractive choice for patients with unmet clinical needs. Currently, there are two major strategies to prepare the cell sources. The first is to use induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs), which can recapitulate the skeletal developmental process and differentiate into various skeletal cells. Skeletal tissues are derived from three distinct origins: the neural crest, paraxial mesoderm, and lateral plate mesoderm. Thus, various protocols have been proposed to recapitulate the sequential process of skeletal development. The second strategy is to extract stem cells from skeletal tissues. In addition to mesenchymal stem/stromal cells (MSCs), multiple cell types have been identified as alternative cell sources. These cells have distinct multipotent properties allowing them to differentiate into skeletal cells and various potential applications for skeletal regeneration. In this review, we summarize state-of-the-art research in stem cell differentiation based on the understanding of embryogenic skeletal development and stem cells existing in skeletal tissues. We then discuss the potential applications of these cell types for regenerative medicine.
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Kaszuba, Marcin D., Paweł Widomski, Tomasz Kiełczawa, and Zbigniew Gronostajski. "The use of a measuring arm with a laser scanner for analysis and support of regenerative surfacing processes of forging dies." Welding Technology Review 92, no. 3 (April 11, 2020): 23–32. http://dx.doi.org/10.26628/wtr.v92i3.1103.

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The article presents the results of research conducted in order to develop the technology of regenerative surfacing of forging dies. The selected example shows how the use of a measuring arm with a laser scanner can be used to support the regeneration process. The tests were conducted in industrial conditions of a forging die. The analysis of the regeneration process was carried out at each of 4 stages: after wear in the forging process, after initial machining, after regenerative surfacing and after final machining. It has been shown that scanning can be used to develop programs for mechanical pre- treatment, to measure the volume of padding welds, to determine the amount of finishing allowance, to verify the effectiveness of the surfacing process and to control the quality of the die before the forging process. The obtained results confirmed the effectiveness of the regeneration carried out. In terms of performance, it has been shown that too much padding weld's material is a machining allowance. For this reason, the treatment is time and energy consuming and about 68% of the padding weld's material is waste or chips. The analysis showed the possibility of saving up to 45% of the weld metal material by using reasonable allowances of smaller thickness. These results indicate the need to modify the regeneration technology and the legitimacy of using robotic surfacing, which can provide greater precision and repeatability in the layingof padding weld’s beads. The next stage of research will be robotization of the analyzed forging die regeneration process using WAAM technology.
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Wang, Kun, Feng Wang, Yu Hai Guo, Hong Yan Tang, and Hua Peng Zhang. "Regeneration of the Absorbent by the PTFE Hollow Fiber Membranes Using Vacuum Membrane Regeneration Technology." Key Engineering Materials 671 (November 2015): 300–305. http://dx.doi.org/10.4028/www.scientific.net/kem.671.300.

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The polytetrafluoroethylene (PTFE) hollow fiber membranes were prepared through a cold pressing method including paste extruding, stretching and sintering in this study. Membrane vacuum regeneration technology (MVR) was developed as a novel regeneration technology for regeneration of the absorbent. The membrane structures of the PTFE hollow fiber membranes were investigated. The mixture of N-methyldiethanolamine and piperazine was selected as the absorbent. The PTFE hollow fiber membranes were used for regeneration through vacuum membrane regeneration technology. The CO2 regeneration flux and regeneration ratio increased with the increase of the regeneration temperature and the CO2 loading. The regeneration pressure was negative to the regeneration flux and regeneration ratio. When the flow rate of the rich solution increased, the regeneration ratio decreased and CO2 regeneration flux increased significantly.
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Dissertations / Theses on the topic "Regeneration technology"

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Moxey, Steven Richard. "Regeneration in high technology marketing channels : antecedents and decision outcomes." Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625134.

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High technology marketing channels face environments characterised by high levels of uncertainty and change, which create continual opportunities for regeneration by forming new business relationships and acquiring new high technology. Marketing channels are an important part of the high technology vendor marketing mix for business markets and are affected by marketing decisions made by marketing executives in the UK. To date the study of relationship exit and renewal in high technology marketing channels has not received attention in the literature and the effect of specific factors that operate in the challenging high technology environment have not been investigated. This study employs a sequential mixed methods research design with an initial qualitative phase to identify specific factors of relationship exit and renewal in high technology marketing channels. The results informed a substantial quantitative phase of telephone interviews. The sample includes small-medium business high technology marketing channels in the UK market and 512 interviews were completed, supported by Cisco Systems, IBM and Vodafone. The study extends the voice-exit theory of relationship exit to the high technology marketing channels context by considering voice-exit from relationships with both high technology vendors and high technology products. Analysis confirms cost of exit as an important antecedent of voice-exit; new antecedents are identified: market adoption benefits and compatibility. These antecedents may be specific to high technology marketing channels. The study includes preliminary testing of hypotheses on the operation of voice, based on a single item measure. Four new decision outcomes for high technology marketing channels are identified: Status Quo, Switcher, Loyal Investor and Switch Investor. Decision outcomes leading to the building of new capability based on new technology, Loyal Investor and Switch Investor are the norm in high technology marketing channels. By contrast, Switcher decision outcomes that involve purely changing vendor relationships appear to be rare. Logistic regression models are developed to quantify the relationship between the antecedent factors and the decision outcomes, identifying the variables that discriminate between decision outcomes. Managerial guidance is developed for practising high technology channel managers to help vendors influence the decision outcomes, requiring new channel marketing strategies. Finally, the evolution of high technology channels into channel networks is reviewed and methods for assessing high technology channel networks are presented.
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Bramhall, Naomi F. "Cochlear hair cell regeneration from neonatal mouse supporting cells." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/78149.

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Thesis (Ph. D. in Speech and hearing Bioscience and technology)--Harvard-MIT Program in Health Sciences and Technology, 2012.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 86-91).
Unlike lower vertebrates, capable of spontaneous hair cell regeneration, mammals experience permanent sensorineural hearing loss following hair cell damage. Although low levels of hair cell regeneration have been demonstrated in the immature mammalian vestibular system, the cochlea has been thought to lack any spontaneous regenerative potential. Inhibition of the Notch pathway can stimulate hair cell generation in neonatal mammals, but the specific source of these new hair cells has been unclear. Here, using in vitro lineage tracing with the supporting cell markers Sox2 and Lgr5, we show that Lgr5-positive inner pillar and 3rd Deiter's cells in gentamicin-damaged organs of Corti from neonatal mice give rise to new hair cells following treatment with a Notch inhibitor. These new hair cells are generated primarily through direct transdifferentiation of supporting cells, although a small number show evidence of proliferation. Inner pillar cells show the greatest transdifferentation capability, giving rise to immature outer hair cells, and transdifferentiating in response to damage even in the absence of Notch inhibition. In vivo pharmacologic inhibition of Notch and in vivo lineage tracing with Sox2 during genetic Notch inhibition provide generally consistent results, although additional new hair cells develop in the inner hair cell region. These data suggest a spontaneous capacity for hair cell regeneration in the neonatal mammalian cochlea. In addition, the data identify Lgr5-positive supporting cells as potential hair cell progenitors, making them an attractive target for future hair cell regeneration treatments.
by Naomi F. Bramhall.
Ph.D.in Speech and hearing Bioscience and technology
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Mishra, Chinmay. "On-Site Regeneration of Granular Activated Carbon : A literature study, comparison and assessment of different regeneration methods to find potential on-site regeneration method in Sweden." Thesis, KTH, Hållbar utveckling, miljövetenskap och teknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-291272.

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In this thesis project, different existing granular activated carbon regeneration methods/technologies are assessed based on existing literature. The project aims to identify and analyse the method with the highest on-site regeneration potential by using the Himmerfjärdsverket wastewater treatment plant as a reference and performing a cost estimation analysis.  Information is gathered about different methods from the literature study and then sorted into the following parts: working principle, technology readiness and cost, advantages and disadvantages, and references (case studies). The methods are then assessed and compared by a scoring and weightage system, where the factors which are regeneration efficiency, ease of implementation, sustainability, cost, and reliability are weighted and then scored for each method. Furthermore, the highest scoring method is then compared to the proposed regeneration method at Himmerfjärdsverket.  The results from my comparison and assessment show that chemical regeneration is the highest scored method, followed by microwave and wet-oxidation regeneration methods. On applying chemical regeneration at Himmerfjärdsverket, it is found out that it may indeed be cheaper and more sustainable than the proposed off-site regeneration method. However, thermal and biological regeneration are better alternatives at Himmerfjärdsverket than microwave and wet- oxidation.  From the above results, chemical regeneration has the highest potential for on-site regeneration of granular activated carbon in Sweden.
Läkemedel i vatten är ett stort hot mot miljö och hälsa. Kommunalt avloppsvatten består av avloppsvatten från hushåll, privata och offentliga institutioner och dagvattenavrinning. En viktig läkemedelskälla i avloppsvatten är ett läkemedel som kommer in via urin och / eller avföring. Olika tekniker finns för avlägsnande av farmaceutiska rester och andra mikroföroreningar från avloppsvatten. En sådan teknik är adsorptionen av dessa rester med hjälp av Granulärt Aktivtkor (GAC). Aktivtkor (AC) är ett kolhaltigt material med liten pordiameter, stora porvolymer och hög specifik yta rea vid bearbetning. Det anses vara det bästa adsorptionsmedlet för att adsorbera organiska, oorganiska och giftiga metalljoner som finns i avloppsvattnet. Det finns två typer av aktivtkol som används för att avlägsna farmaceutiska rester: Granulärt aktivtkol och pulveriserat aktivt kol.  Denna forskning syftar till att identifiera, jämföra och bedöma befintlig regenereringsteknik för att hitta den teknik som har störst potential och använda den på ett referensavloppsreningsverk. Det finns olika metoder för regenerering av använt aktivt kol (SAC). Dessa är termisk regenerering, kemisk regenerering, biologisk regenerering, elektrokemisk regenerering, mikrovågsregenerering och våt-oxidationsregenerering. Metoderna listas och förklaras med hjälp av deras arbetsprincip, beredskap, kostnad, fördelar, nackdelar och referenser till studier där de har använts.  Flera kriterier / faktorer beaktas för bedömning och jämförelse av olika regenereringsmetoder. Faktorerna poängsätts sedan med hjälp av ett viktat poängsystem. Var och en av de ovannämnda faktorerna görs mellan 0–5 och tilldelas en vikt mellan 1–3. En högre poäng betyder bättre prestanda i den givna faktorn. Medan en högre vikt betyder betydelsen av faktorn.  Från bedömningen visar sig kemisk regenerering vara den mest lämpliga metoden för regenerering av GAC på plats. Den minst lämpliga metoden är biologisk regenerering med en total poäng på 39. De två bästa regenereringsmetoderna på plats är kemisk och mikrovågsregenerering. I procent har kemisk regenerering och mikrovågsregenerering en rating på 93,3% och 90%. För att validera resultatet av bedömningen används Himmerfjärdsverket som referensavloppsverk.  Himmerfjärdsverket bygger om och expanderar till en högteknologisk anläggning. Den nya anläggningen kommer att bestå av modern reningsteknik och hög reningskapacitet. Den planerade nya anläggningen förväntas vara klar 2025, medan byggandet påbörjades i januari 2020.  I en studie genomförd av Syvab i samarbete med Ramboll, IVL och SU anges att det skulle behövas kolförbrukning på 15–20 g / m3 vatten. Den totala kostnaden per behandlat avloppsvatten skulle sannolikt öka med 20–30% till 2027 om läkemedelsreningen genomförs på Himmerfjärdsverket med hjälp av GAC och av regenereringsmetoden utanför anläggningen. Himmerfjärdsverket kommer att konsumera 3,92 ton kol dagligen eller 27,56 ton varje vecka. Detta kommer att kosta 28,7 miljoner SEK / år för 20 000 EBV (i värsta fall) och 11,5 miljoner SEK / år för 50 000 EBV.  Medan kostnaden för kemisk regenerering av GAC med högsta regenereringseffektivitet uppskattas till 27,4 miljoner SEK / år för användning av flytande NaOH-lösning och 17,7 miljoner SEK / år för användning av fast NaOH för 20 000 EBV. För mängden 573 t / år kol kommer NaOH-förbrukningen att vara 2083,5 t / år, vilket kommer att kosta 7,1 och 10,9 miljoner SEK / år för 50 000 EBV.  Eftersom kostnad är en av de viktigaste faktorerna som motverkar tillämpningen av metoder som är lika tillförlitliga som termisk regenerering. Om termisk regenerering implementeras på Himmerfjärdsverket kan installationen användas för att regenerera GAC från andra reningsverk från Stockholm. 2 GAC-bio filter i serieskapare bättre förutsättningar för biologisk regenerering av GAC samt ger låga föroreningskoncentrationer och höga syrekoncentrationer. För att lägga till det producerar Himmerfjärdsverket biogas som kan användas för att uppnå höga temperaturer som krävs enligt denna metod eller generera den erforderliga elen eller båda. I alla tre fall kommer kostnaden att minskas ytterligare.  Avslutningsvis har kemisk regenerering den högsta regenereringspotentialen på plats bland alla andra studerade metoder. Medan termisk regenerering är nära den andra på grund av kolförlusten. En pilotstudie krävs för att validera de regenereringseffektivitet som nämns i litteraturen och bearbetningsförhållandena och typerna av adsorbera vid Himmerfjärdsverket behöver utvärderas liksom behandlingsförhållandena.
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Zhang, Zhifen. "Use of genetic transformation technology in oil crops: soybean and sunflower." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1462871872.

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Sarver, Emily Allyn. "The Ferrous Regeneration Process for Use in Alternate Anode Reaction Technology in Copper Hydrometallurgy." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/34291.

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The Fe(II) regeneration process is an important aspect of Alternate Anode Reaction Technology (AART) using Fe(II)/Fe(III)-SO2 reactions for copper hydrometallurgy; however little has been done to study it specifically. The process regenerates Fe(II) via Fe(III) reduction by SO2(aq), catalyzed by activated carbon particles. To better understand and improve the process, two studies have been conducted with respect to variable factors and their affects on the regeneration. A study of fundamental kinetics confirms that the regeneration reaction is mass transfer-controlled, requiring adsorption of reactants onto the catalyst surface for reaction. The reaction rate is limited by the diffusivity of Fe(III). Initial Fe(III) concentration and carbon particle size are determined to be the most influential factors on the rate under the condition studied. Furthermore, it is observed that flow rate may inhibit the reaction by reducing ion diffusivity. A rate expression for the regeneration is derived and experimentally validated, and the Fe(III) diffusivity is determined to be 1.1x10-7 cm2/s. An optimization problem is also developed and solved for the process, constrained by the requirement that negligible SO2 could be present in the process effluent. Before optimization, a relationship is developed between regeneration rate and variable factors. Again, carbon size and initial Fe(III) are the most influential factors on the regeneration rate, related to it linearly; temperature is significant with a squared relationship to the rate; initial SO2 is insignificant. Optimal conditions are found with minimum carbon particle size, maximum initial Fe(III) concentration, and moderate temperature.
Master of Science
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Okamoto, Satoshi. "Investigation of retinal regeneration by cell therapy with the induced pluripotent stem cell technology." Kyoto University, 2013. http://hdl.handle.net/2433/175084.

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Prina, Elisabetta. "Recreating 3D limbal architectures by two-photon polymerization for cornea regeneration." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/49875/.

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Limbal Epithelial Crypts (LECs) are stem cell niches located in the limbus, the area between the cornea and the conjunctiva, and are responsible for cornea epithelium regeneration. Their anatomical structures were identified and described by Dua et al (2005). Stem cells migrate from this area toward the cornea where they differentiate into corneal epithelial cells. The lack of the LECs determines a pathology called Limbal Stem Cell Deficiency (LSCD) that can cause conjunctivalization, neovascularisation, corneal opacification, eventually resulting in vision loss. Currently, the main carriers to support limbal stem cell proliferation and differentiation used in clinics do not include enclosed structures able to act as cell reservoirs. In addition, the driving forces that determine the migration and the differentiation of limbal stem cells are not clarified yet. The hypotheses of this thesis were that the stiffness and the geometry of the scaffold influence the limbal stem cell differentiation process. Understanding these key factors could help to inform the design of scaffolds for future cornea regeneration strategies. The effect of the stiffness on cell differentiation is a well-known mechanism, but is less investigated in the limbus-corneal tissue. In this work, it was studied by producing macro-scaffolds (d=8 mm) obtained by UV-crosslinking. The stiffness was varied by increasing the concentration of Gelatin Methacrylate (GelMA), a biocompatible, photocrosslinkable material. Compression tests, rheology, AFM, and swelling analysis were performed on the developed hydrogels and compared to the ex vivo human cornea values. The gels with a concentration between 5% and 15% (w/v) exhibited mechanical properties in the same order of magnitude obtained for the cornea. The results indicated that the increased stiffness did not have a significant impact either in the expression of cytokeratin (CK3/CK14, stem cell marker, and CK14, differentiation marker), or in the gene expression (KRT3 and KRT19). However, the secondary key factors explored, differentiation media and oxygen concentration, supported cell differentiation. Inkjet printing was investigated as an additive manufacturing technique to produce 3D architectures. Although with this technique it was possible to develop a 3D structure with a stiffness gradient, its resolution was not sufficiently high to obtain a structure with dimensions comparable to the in vivo limbal stem cell niche. The second hypothesis was verified by developing a biocompatible scaffold mimicking the structure of the limbal stem cell niche and by evaluating the impact of its architecture on stem cell differentiation. The crypt geometry was modelled as U-shaped scaffolds with a diameter narrowing from 200 μm to 20 μm and was micro-fabricated from GelMA/PEGDA-based hydrogels using a Two-Photon Polymerization system (2PP). However, it was proven that the use of riboflavin as photoinitiator was inefficient at 780 nm, the wavelength used in the 2PP system. For this reason, P2CK was used as photoinitator to obtain stable hydrogels. The 2PP system allowed the precise recreation of the exact dimensions of the native crypts. Swelling, susceptibility to enzymatic degradation and stiffness were all evaluated. The biocompatibility of the printed scaffolds was assessed using immortalized human corneal epithelial cell proliferation up to 14 days. The ability of limbal stem cells to repopulate the crypts was demonstrated via two strategies. In the first strategy, human limbal stem cells were seeded directly inside the niche whilst in the second strategy, primary human limbal explants were placed adjacent to the printed structures and cells migrated towards the scaffold. Cell distribution and differentiation along the z-axis were evaluated using confocal microscopy. Cytokeratin 14 (CK14) with p63 and Cytokeratin CK3/12 (CK3/12) were used as limbal stem cell and differentiated corneal epithelial cell markers, respectively. Limbal epithelial stem cells were cultured in two conditions: xeno-free media, and with primary cells in serum containing media on a feeder layer. Both conditions showed the zonation of markers along the z-axis, which was not observed on flat scaffolds, demonstrating that the geometry alone influences cell phenotype. This suggests that the enclosed geometry results in the generation of a microenvironment inside the niche that influences cell phenotype. The presence of soluble factors, generated by cellular secretions, a specific oxygen concentration, and a more ‘stressful’ biomechanical milieu for the cells are some hypotheses that need further investigation and will be the basis of future work. In conclusion, the hypotheses of this thesis were partially confirmed. The variation in gel stiffness did not allow for the control of the hLESC differentiation process. However, the results demonstrated the influence of the geometry on stem cell differentiation without the use of signaling molecules. Further studies are necessary to have a description of the detailed spatial variability of the scaffold’s characteristics. Overall, the 2PP approach is flexible and could be applied to the generation of stem cell niches of other tissues, and could represent a significant advance in regenerative medicine.
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Pound, Jodie Claire. "Strategies for cartilage regeneration : use of human mesenchymal stem cells, alginate microcapsules and bioreactor technology." Thesis, University of Southampton, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440411.

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Viswanath, Aiswarya. "Dental stem cell delivery through new injectable matrices for spinal cord regeneration." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/47606/.

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Traumatic spinal cord injury (SCI) is a global health problem involving complex pathophysiological cascade and afflicts both developing and developed countries. Transplantation of Mesenchymal stem cell population such as dental stem cells (DSC) have demonstrated preclinical potential for central nervous system (CNS) repair. The work presented in this thesis has evaluated the potential of dental stem cells from apical papillae (SCAP) in combination with different biomaterials for SCI repair. ECM scaffolds were produced from different mammalian tissues including spinal cord, bone and dental hard tissue using different decellularisation processes. Scaffolds were then digested with pepsin to allow solubilisation and hydrogel formation. The ECM hydrogels were characterised and embedded with SCAP to investigate the effect of morphological and biochemical properties upon cell characteristics. All the hydrogels maintained high cell viability and an increase in the cell number with a satisfactory metabolic activity. However, only ECM hydrogels from decellularised spinal cord and bone tissue supported the expression of neural lineage and pro angiogenic markers with stronger responses observed with spinal cord ECM hydrogels. Biodegradable PLGA-Triblock (PLGA-TB) microparticles were fabricated to provide controlled release of glial cell derived neurotrophic factor (GDNF) and may facilitate SCAP attachment. An optimal PLGA-TB microparticle formulation was selected based on the size, surface morphology and release profile achieved. All commercial preparation of GDNF being stabilised in salt, a modified protocol was required to prepare microparticles. The formulation was modified with 10mM sodium acetate which led to a successful encapsulation and sustained release of bioactive GDNF. To support SCAP attachment and survival, PLGA-TB microparticles surfaces were coated with different ECM pre-gel solutions (spinal cord and bone tissue ECM) and laminin. Assessment of surface coating with ToF-SIMS showed protein adsorption on all the coated microparticles, with a higher adsorption on ECM pre-gel coated microparticles. All the surface modified PLGA-TB microparticles supported prolonged SCAP attachment and survival. Laminin and bone ECM pre-gel coated microparticles promoted a significant increase in SCAP number after 7 days. Over all, the result in this thesis have shown that SCAP combined with decellularised mammalian tissue derived ECM hydrogels or GDNF loaded PLGA-TB microparticles may facilitate delivery of autologous stem cells to promote spinal cord repair.
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Breinan, Howard Alan 1968. "Development of a collagen-glycosaminoglycan analog of extracellular matrix to facilitate articular cartilage regeneration." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/49641.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1998.
Includes bibliographical references (leaves 205-220).
by Howard Alan Breinan.
Ph.D.
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Books on the topic "Regeneration technology"

1

Yao, Ye. Ultrasonic technology for desiccant regeneration. Singapore: John Wiley & Sons Inc., 2014.

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Yao, Ye, and Shiqing Liu. Ultrasonic Technology for Desiccant Regeneration. Singapore: John Wiley & Sons Singapore Pte. Ltd, 2014. http://dx.doi.org/10.1002/9781118921616.

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Bonner, F. T. Seed biology and technology of Quercus. New Orleans, La: U.S. Dept of Agriculture, Forest Service, Southern Forest Experiment Station, 1987.

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Hunt, J. A. Mechanical site preparation and forest regeneration in Sweden and Finland: Implications for technology transfer. Victoria, B.C: Canadian Forestry Service, 1988.

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Gribko, Linda S. Biotic and abiotic mechanisms in the establishment of northern red oak seedlings: A review. Newtown Square, PA: USDA Forest Service, Northeastern Research Station, 2002.

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Hutton, T. A. The new economy of the inner city: Restructuring, regeneration, and dislocation in the 21st century metropolis. Abingdon, Oxon, UK: Routledge, 2008.

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Hutton, T. A. The new economy of the inner city: Restructuring, regeneration and dislocation in the 21st century metropolis. New York, NY: Routledge, 2010.

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Hutton, T. A. The new economy of the inner city: Restructuring, regeneration and dislocation in the 21st century metropolis. New York, NY: Routledge, 2010.

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Raigrodski, Ariel J. Soft tissue management: The restorative perspective : putting concepts into practice. Chicago: Quintessence Publishing Co, Inc., 2015.

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The new economy of the inner city: Restructuring, regeneration, and dislocation in the 21st century metropolis. Abingdon, Oxon, UK: Routledge, 2008.

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Book chapters on the topic "Regeneration technology"

1

Ajioka, Itsuki. "Molecular Technology for Injured Brain Regeneration." In Molecular Technology, 71–85. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2019. http://dx.doi.org/10.1002/9783527823987.vol2_c4.

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Woodyer, Ryan D., Tyler W. Johannes, and Huimin Zhao. "Regeneration of Cofactors for Enzyme Biocatalysis." In Enzyme Technology, 85–103. New York, NY: Springer New York, 2006. http://dx.doi.org/10.1007/978-0-387-35141-4_5.

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Castaño, Oscar, Mohamed Eltohamy, and Hae-Won Kim. "Electrospinning Technology in Tissue Regeneration." In Methods in Molecular Biology, 127–40. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-388-2_9.

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Mondal, Sourav, Mihir Kumar Purkait, and Sirshendu De. "Surfactant-Enhanced Carbon Regeneration." In Green Chemistry and Sustainable Technology, 141–51. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-6293-3_4.

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Basu, Bikramjit, and Sourabh Ghosh. "Assessment of Technology and Manufacturing Readiness Levels." In Biomaterials for Musculoskeletal Regeneration, 235–46. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-3017-8_11.

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Rigby, Sean, Gerd Modes, Stevan Jovanovic, John Wei, Koji Tanaka, Peter Moser, and Torsten Katz. "BASF Technology for CO2Capture and Regeneration." In Gas Injection for Disposal and Enhanced Recovery, 193–226. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118938607.ch11.

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Wichmann, R., and D. Vasic-Racki. "Cofactor Regeneration at the Lab Scale." In Technology Transfer in Biotechnology, 225–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/b98911.

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Morales, Andres, and Sara Calvo. "Digital Technology as a Tool for Social Regeneration." In Social Regeneration and Local Development, 187–208. New York, NY : Routledge, 2017.: Routledge, 2017. http://dx.doi.org/10.4324/9781315302478-11.

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Choi, Jong Woo, Namkug Kim, and Chang Mo Hwang. "3D Printing Technology in Craniofacial Surgery and Salivary Gland Regeneration." In Salivary Gland Development and Regeneration, 173–91. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-43513-8_9.

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Koyama, Yoshihisa, Masanori Kikuchi, Shigeo Tanaka, Junzo Tanaka, and Kazuo Takakuda. "Bone Regeneration with β-TCP/PLGC Membranes." In Advances in Science and Technology, 258–62. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/3-908158-05-2.258.

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Conference papers on the topic "Regeneration technology"

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Sahruddin, Nursyaheera, and Asmarashid Ponniran. "Life Cycle Assessment And Performances of Revived Industrial Lead-Acid Batteries Through Regeneration Technology : Regeneration Technology." In Conference on Faculty Electric and Electronic 2020/1. Penerbit UTHM, 2020. http://dx.doi.org/10.30880/eeee.2020.01.01.009.

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The growing amount of battery production will produce more substances which increase the number of harmful chemicals to the environment such as carbon dioxide, nitrogen, and sulfur dioxide. Since most Malaysians are thrown their old batteries away and replace with new batteries. The recycled batteries and revived batteries are ways to reduce the number of batteries being disposed of. Hence this study aims to determine the carbon footprint and performances of revived industrial lead-acid batteries through regeneration technology. In this study, life cycle assessment is used as a method to assess environmental impacts on which carbon footprint associated with all the stages of a batteries' life through the regeneration technology. The three processes involved in regeneration technology which charging process, discharging process, and regeneration process to evaluated the voltage, capacity, and specific gravity. From the results, the revived industrial lead-acid batteries through regeneration technology are 199.91 kgCO2-eq of a carbon footprint than recycled batteries and the discharge time of 6 batteries are increased from 3 hours 55 minutes to 5 hours after using the regeneration technology. Thus, it is confirmed the revived industrial lead-acid batteries through regeneration technology are to be used preferably in reducing the disposed of batteries.
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Stefan-Cristian, Macovei, Curelaru Alina Cornelia, and Ursache Stefan. "Battery regeneration technology using dielectric method." In 2014 International Conference and Exposition on Electrical and Power Engineering (EPE). IEEE, 2014. http://dx.doi.org/10.1109/icepe.2014.6970029.

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Guang Chen, Lixia Xi, Yongxin Ma, Lingyu Sun, and Xiaoguang Zhang. "Regeneration of DQPSK signals using semiconductor optical amplifier-based phase regenerator." In International Conference on Advanced Infocomm Technology 2011 (ICAIT 2011). IET, 2011. http://dx.doi.org/10.1049/cp.2011.1081.

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Kjøller, Niels-Kristian, Francesco Da Ros, Kasper Meldgaard Røge, Michael Galili, and Leif K. Oxenløwe. "QPSK Regeneration without Active Phase-Locking." In CLEO: Applications and Technology. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/cleo_at.2016.jth2a.119.

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Carapellucci, Roberto, and Lorena Giordano. "Enhancing Energy and Economic Performances of Combined Cycle Power Plants by Means of Gas-Cycle Regeneration." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-38297.

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Efficiency improvement in the gas turbine sector has been mainly driven by increasing the turbine inlet temperature and compressor pressure ratio. For a fixed technology level, a further efficiency gain can be achieved through the utilization of waste thermal energy. Regeneration is an internal recovery technique that allows the reduction of heat input required at combustor, by preheating the air at compressor outlet. Under certain operating conditions, the temperature of exhaust gas leaving the regenerator is still enough high to allow the steam production via an heat recovery steam generator (HRSG). Regeneration in steam-gas power plants (CCGT) has the potential to enhance thermal efficiency, but reduces the margins for external recovery and then the bottoming steam cycle capacity. Moreover, the reduction of exhausts temperature at gas turbine outlet requires the reconsideration of HRSG operating parameters, in order to limit the increase of waste heat at the stack. The aim of this study is to explore the potential benefits that regeneration in the gas cycle gives on the whole steam-gas power plant. The extent of energy and economic performances improvement is evaluated, varying the gas turbine specifications and the layout and operating conditions of HRSG. Hence simple and regenerative configurations based on single and multi-pressure HRSG are compared, focusing on efficiency, specific CO2 emissions and unit cost of electricity (COE).
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Lu, Chao, Dong Guo, Wentao Zhu, Zhen Du, Mingxuan Wang, and Yang Zhang. "Research progress of honeycomb denitrification catalyst regeneration technology." In 2021 IEEE Sustainable Power and Energy Conference (iSPEC). IEEE, 2021. http://dx.doi.org/10.1109/ispec53008.2021.9735522.

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Jashari, Rineta, Zana Prelvukaj, and Faton Spahiu. "Reuse and regeneration of industrial zones." In University for Business and Technology International Conference. Pristina, Kosovo: University for Business and Technology, 2017. http://dx.doi.org/10.33107/ubt-ic.2017.13.

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Sullivan, Belle, Marc Rubin, David Tauman, Asgar Ali, and Khanjan Mehta. "Mushroom Mycelium Regeneration in Tropical Environments." In 2020 IEEE Global Humanitarian Technology Conference (GHTC). IEEE, 2020. http://dx.doi.org/10.1109/ghtc46280.2020.9342848.

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Putrya, Boris M., Nikolay A. Bazaev, and Nikita M. Zhilo. "Electrochemical Method of Dialysate Regeneration." In 2019 Ural Symposium on Biomedical Engineering, Radioelectronics and Information Technology (USBEREIT). IEEE, 2019. http://dx.doi.org/10.1109/usbereit.2019.8736598.

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Ganev, Evgeni, and Bulent Sarlioglu. "Improving Load Regeneration Capability of an Aircraft." In Aerospace Technology Conference and Exposition. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2009. http://dx.doi.org/10.4271/2009-01-3189.

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Reports on the topic "Regeneration technology"

1

SAMS TL and GUILLOT S. TECHNOLOGY MATURATION PLAN FOR ALUMINUM REMOVAL AND SODIUM HYDROXIDE REGENERATION FROM HANFORD WASTE BY LITHIUM HYDROTALCITE PRECIPITATION. Office of Scientific and Technical Information (OSTI), January 2011. http://dx.doi.org/10.2172/1010334.

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Heldebrant, David. CO2-Binding Organic Liquids Gas Capture with Polarity-Swing-Assisted Regeneration Full Technology Feasibility Study B1 - Solvent-based Systems. Office of Scientific and Technical Information (OSTI), August 2014. http://dx.doi.org/10.2172/1151840.

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Lopez, A., J. White, F. R. Groves, and D. P. Harrison. Advanced sulfur control concepts in hot-gas desulfurization technology: Phase 1, Feasibility of the direct production of elemental sulfur during the regeneration of high temperature desulfurization sorbents. Office of Scientific and Technical Information (OSTI), October 1994. http://dx.doi.org/10.2172/10113213.

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Lopez, A., W. Huang, and J. White. Advanced sulfur control concepts in hot-gas desulfurization technology: Phase 2. Exploratory studies on the direct production of elemental sulfur during the regeneration of high temperature desulfurization sorbents. Topical report. Office of Scientific and Technical Information (OSTI), July 1997. http://dx.doi.org/10.2172/594440.

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Perl, Avichai, Bruce I. Reisch, and Ofra Lotan. Transgenic Endochitinase Producing Grapevine for the Improvement of Resistance to Powdery Mildew (Uncinula necator). United States Department of Agriculture, January 1994. http://dx.doi.org/10.32747/1994.7568766.bard.

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The original objectives are listed below: 1. Design vectors for constitutive expression of endochitinase from Trichoderma harzianum strain P1. Design vectors with signal peptides to target gene expression. 2. Extend transformation/regeneration technology to other cultivars of importance in the U.S. and Israel. 3. Transform cultivars with the endochitinase constructs developed as part of objective 1. A. Characterize foliar powdery mildew resistance in transgenic plants. Background of the topic Conventional breeding of grapevines is a slow and imprecise process. The long generation cycle, large space requirements and poor understanding of grapevine genetics prevent rapid progress. There remains great need to improve existing important cultivars without the loss of identity that follows from hybridization. Powdery mildew (Uncinula necator) is the most important fungal pathogen of grapevines, causing economic losses around the world. Genetic control of powdery mildew would reduce the requirement for chemical or cultural control of the disease. Yet, since the trait is under polygenic control, it is difficult to manipulate through hybridization and breeding. Also, because grapevines are heterozygous and vegetatively propagated cultivar identity is lost in the breeding process. Therefore, there is great need for techniques to produce transgenic versions of established cultivars with heterologous genes conferring disease resistance. Such a gene is now available for control of powdery mildew of grapevines. The protein coded by the Endochitinase gene, derived from Trichoderma harzianum, is very effective in suppressing U. necator growth. The goal of this proposal is to develop transgenic grapevines with this antifungal gene, and to test the effect of this gene on resistance to powdery mildew. Conclusions, achievements and implications Gene transfer technology for grape was developed using commercial cultivars for both wine and table grapes. It paved the way for a new tool in grapevine genetic studies enabling the alteration of specific important traits while maintaining the essential features of existing elite cultivars. Regeneration and transformation technologies were developed and are currently at an advanced stage for USA wine and Israeli seedless cultivars, representing the cutting edge of grape genetic engineering studies worldwide. Transgenic plants produced are tested for powdery mildew resistance in greenhouse and field experiments at both locations. It is our ultimate goal to develop transgenic grapes which will be more efficient and economical for growers to produce, while also providing consumers with familiar products grown with reduced chemical inputs.
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Partap, T., and H. R. Watson. Sloping Agricultural Land Technology (SALT): A Regenerative Option for Sustainable Mountain Farming; ICIMOD Occasional Paper No. 23. Kathmandu, Nepal: International Centre for Integrated Mountain Development (ICIMOD), 1994. http://dx.doi.org/10.53055/icimod.176.

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Partap, T., and H. R. Watson. Sloping Agricultural Land Technology (SALT): A Regenerative Option for Sustainable Mountain Farming; ICIMOD Occasional Paper No. 23. Kathmandu, Nepal: International Centre for Integrated Mountain Development (ICIMOD), 1994. http://dx.doi.org/10.53055/icimod.176.

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Shan, Yina, Praem Mehta, Duminda Perera, and Yurissa Yarela. Cost and Efficiency of Arsenic Removal from Groundwater: A Review. United Nations University Institute for Water, Environment and Health, February 2019. http://dx.doi.org/10.53328/kmwt2129.

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Hundreds of millions of people worldwide are exposed to arsenic-contaminated drinking water, leading to significant health complications, and social and economic losses. Currently, a wide range of technologies exists to remove arsenic from water. However, despite ongoing research on such technologies, their widespread application remains limited. To bridge this gap, this review aims to compare the effectiveness and costs of various arsenic remediation technologies while considering their practical applicability. A search conducted using the Medline and Embase databases yielded 31 relevant articles published from 1996 to 2018, which were categorized into laboratory and field studies. Data on the effectiveness of technologies in removing arsenic and associated costs were extracted and standardized for comparison as much as was possible, given the diversity of ways that studies report their key results. The twenty-three (23) technologies tested in laboratory settings demonstrated efficiencies ranging from 50% to ~100%, with the majority reaching relatively high removal efficiencies (>90%). Approximately half achieved the WHO standard of 10 µg/L. Laboratory studies used groundwater samples from nine (9) different countries – Argentina, Bangladesh, Cambodia, China, Guatemala, India, Thailand, the United States, and Vietnam. The fourteen (14) technologies tested in the field achieved removal efficiency levels ranging between 60% and ~99%, with ten (10) attaining above 90% removal efficiency. Of these, only five (5) reached established the WHO standard. Some of the technologies under-performed when their influent water contained excessive concentrations of arsenic. Only six (6) countries (Argentina, Bangladesh, Chile, China, India, and Nicaragua) were represented among the studies that implemented and tested technologies in the field, either at household or community level. For technologies tested in the laboratory, the cost of treating one cubic meter of water ranged from near-zero to ~USD 93, except for one technology which cost USD 299/m³. For studies conducted in the field, the cost of treating one cubic meter of water ranged from near-zero to ~USD 70. Key factors influencing the removal efficiencies and their costs include the arsenic concentration of the influent water, pH of the influent water, materials used, the energy required, absorption capacity, labour used, regeneration period and geographical location. Technologies that demonstrate high removal efficiencies when treating moderately arsenic-contaminated water may not be as efficient when treating highly contaminated water. Also, the lifetime of the removal agents is a significant factor in determining their efficiency. It is suggested that remediation technologies that demonstrate high arsenic removal efficiencies in a laboratory setting need to be further assessed for their suitability for larger-scale application, considering their high production and operational costs. Costs can be reduced by using locally available materials and natural adsorbents, which provide near zero-cost options and can have high arsenic removal efficiencies. A notable feature of many arsenic removal approaches is that some countries with resource constraints or certain environmental circumstances – like typically high arsenic concentrations in groundwater –aim to reach resultant arsenic concentrations that are much higher than WHO’s recommended standard of 10 µg/L. This report maintains that – while this may be a pragmatic approach that helps progressively mitigate the arsenic-related health risks – it is unfortunately not a sustainable solution. Continuing exposure to higher levels of arsenic ingestion remains harmful for humans. Hence arsenic-removal technology should only be seen efficient if it can bring the water to the WHO standard. A less radical approach effectively shifts the attention from the origin of the problem in addressing the impacts and postpones achieving the best possible outcome for populations. The quantitative summary of costs and effectiveness of arsenic remediation technologies reviewed in this report can serve as a preliminary guideline for selecting the most cost-effective option. It may also be used as an initial guideline (minimum standard) for summarising the results of future studies describing arsenic remediation approaches. Looking ahead, this study identifies four priority areas that may assist in commercializing wide-scale implementation of arsenic removal technologies. These include: i) focusing efforts on determining market viability of technologies, ii) overcoming practical limitations of technologies, iii) determining technology contextual appropriateness and iv) concerted effort to increase knowledge sharing in and across regions to accelerate the implementation of research on the ground. Overall, the current science and knowledge on arsenic remediation technologies may be mature enough already to help significantly reduce the global numbers of affected populations. The missing link for today’s arsenic removal challenge is the ability to translate research evidence and laboratory-level successes into quantifiable and sustainable impacts on the ground. Achieving this requires a concerted and sustained effort from policymakers, engineers, healthcare providers, donors, and community leaders.
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