Dissertations / Theses on the topic 'Reflui'
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Vasmara, Ciro <1980>. "Produzione di bioidrogeno da reflui di caseificio." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amsdottorato.unibo.it/8574/1/Tesi_Vasmara_ITA.pdf.
Full textIn this study, the H2 production from dairy waste was evaluated. Scotta permeate was used as substrate. Scotta permeate is the residue of the recovery of the whey proteins, by means of ultrafiltration, from scotta which is the residue of the production of ricotta from cheese whey. This liquid is still rich in lactose (51 g L-1) and suitable for H2 production in dark fermentation (DF). DF is regulated by many parameters and it has still dark sides. The attention was focused, in particular, on the effect of pH on H2 production, on metabolites production (volatile fatty acids, ethanol and lactic acid) and on the microbial community involved in the DF, by means of high-throughput sequencing (HTS), in an unbuffered system. The production of H2 was strongly influenced by the initial pH: it was much higher (+ 31%) in the reactors at alkaline pH (8 - 10) in comparison with the reactors at pH <6. The study of the microbial community indicated that the manipulation of the initial pH influenced the interspecific relationships of the populations resident in the reactors. The alkaline pH favored the proliferation of one genus in particular, Trichococcus. Although this genus is not an hydrogen-producer, its proliferation and, therefore, its metabolic activity in the phase immediately preceding the DF, has created the optimal conditions for the activity of the clostridia (H2 producers) who have started to produce H2 when the pH had dropped to 5.4. The clostridia were more active in reactors with initial alkaline pH, that is, where Trichococcus were most abundant.
Zoli, Raffaele. "Analisi di efficienza energetica dell'impianto di depurazione di reflui di Ravenna." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amslaurea.unibo.it/1715/.
Full textFiorotto, Federico <1988>. "Co-digestione anaerobica di fanghi secondari e reflui vinicoli: ottimizzazione di processo." Master's Degree Thesis, Università Ca' Foscari Venezia, 2012. http://hdl.handle.net/10579/1990.
Full textLOPES, Vincenzo. "trattamento dei reflui civili urbani del comune di Palermo mediante radiazioni ionizzanti." Doctoral thesis, Palermo, 2012. http://hdl.handle.net/10447/94277.
Full textRodio, Mario. "Da reflui urbani ad acque di irrigazione: Un caso di studio dalla Puglia." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/5979/.
Full textMALLOCI, EMANUELA. "Applicazione del processo a fanghi aerobici granulari per il trattamento di reflui petrolchimici." Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266894.
Full textNicoli, Giuditta. "Progetto di smatimento on-site dei reflui urbani del quartiere di Ambalamanga (Mahajanga, Madagascar)." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amslaurea.unibo.it/318/.
Full textMugnaini, Irene. "Recupero dei metalli preziosi dai reflui di lavorazione dell'impianto UNOAERRE: modalità, problematiche e alternative." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017.
Find full textSPINELLI, MATTEO. "Studio del processo biologico via nitrito applicato a reflui a basso carico di azoto." Doctoral thesis, Università Politecnica delle Marche, 2018. http://hdl.handle.net/11566/252879.
Full textThe growing attention to the research of new wastewater treatment processes pursues the objective of combine the achievement of high quality standards in the effluent, the reduction of pollutants released directly or indirectly into the atmosphere and the recovery of energy and precious raw materials from wastewater. The performances of the via nitrite process for the treatment of low strength of nitrogen wastewater was evaluated on a 3 m3 pilot plant, fed with real urban wastewater, in order to understand the mechanisms that promote the start-up and stability of the process. Studying selectively the combination of the different parameters involved, we tried to highlight those that most affect the performance of the process, trying to speed up the start-up phase and progressively reduce the dosage of the external reagents needed for the biomass conditioning. The experimentation was divided in three parts, each corresponding to a different work configuration. Each configuration was preceded by preliminary studies in the laboratory and then the results obtained were validated on the demonstrative scale. Moreover, during the pilot scale phases, through the continuous monitoring of gaseous emissions, we tried to understand the mechanisms of formation and release into the atmosphere of off-gasses, focusing the attention on nitrous oxide (N2O). Through the monitoring of the kinetic constants, a considerable difference in terms of performance has been highlighted according to the inhibition strategy adopted, moving from a stable 90% via nitrite process in the initial configuration to around 10% during the conditioning of the influent flow. The conditions applied for the inhibition of nitrifying bacteria and the long maintenance of the biomass inhibition have allowed a remarkable increase in nitrite speeds, allowing a considerable decrease in the amount of nitrous oxide released.
Aldrovandi, Aba <1977>. "Ottimizzazione dei processi depurativi di reflui ad elevato carico organico a fini di recupero energetico." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2723/1/Aldrovandi_Aba_tesi.pdf.
Full textAldrovandi, Aba <1977>. "Ottimizzazione dei processi depurativi di reflui ad elevato carico organico a fini di recupero energetico." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2723/.
Full textFavaro, Michele <1987>. "Caratterizzazione di reflui industriali e messa a punto di procedure per l'abbattimento di inquinanti specifici." Master's Degree Thesis, Università Ca' Foscari Venezia, 2012. http://hdl.handle.net/10579/2222.
Full textBreda, Valentina <1986>. "OTTIMIZZAZIONE DEL PROCESSO DI CO-DIGESTIONE ANAEROBICA DI REFLUI VINICOLI IN MISCELA CON FANGHI SECONDARI." Master's Degree Thesis, Università Ca' Foscari Venezia, 2014. http://hdl.handle.net/10579/5671.
Full textPERRA, MARIANNA. "Sviluppo di tecnologie alternative per il trattamento biologico di reflui ad elevato contenuto di azoto." Doctoral thesis, Università degli Studi di Cagliari, 2014. http://hdl.handle.net/11584/266483.
Full textTinello, Anna <1994>. "LCA comparativa di due processi di trattamento del digestato da fermentazione di rifiuti e reflui organici." Master's Degree Thesis, Università Ca' Foscari Venezia, 2018. http://hdl.handle.net/10579/13969.
Full textMalerba, Matteo. "Allestimenti di reattori multistadio per la digestione anaerobica dei reflui agro-industriali e confronto con processo convenzionale." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amslaurea.unibo.it/2523/.
Full textTyrolt, Antonella <1988>. "Verifica del processo di codigestione anaerobica di reflui vinicoli e specie erbacee annuali (meccanismo bonus decreto biometano)." Master's Degree Thesis, Università Ca' Foscari Venezia, 2015. http://hdl.handle.net/10579/5779.
Full textRenna, Stefano. "Effetti della Lemna minor sui reflui del depuratore Santerno (Imola). Tasso di crescita e potenzialità di riutilizzo energetico." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017.
Find full textTaccari, Manuela. "Utilizzazione di reflui oleari. Bioconversioni mediante fermentazione e compostaggio di acque di vegetazione per la produzione di biofertilizzanti." Doctoral thesis, Università Politecnica delle Marche, 2009. http://hdl.handle.net/11566/242381.
Full textSantinelli, Martina. "Processi biologici avanzati per il trattamento di reflui ad alto contenuto di nutrienti e valutazione delle emissioni gassose." Doctoral thesis, Università Politecnica delle Marche, 2015. http://hdl.handle.net/11566/242934.
Full textThe widespread application of the anaerobic digestion process for the stabilisation of zootechnical waste determined the need to define possible treatments techniques of the liquid supernatant, to reduce the nitrogen N content and hence the pollution due to its spreading, according to the 91/676/ECC Directive. The removal performances of the continuous nitritation-denitritation automated process were evaluated in a single reactor of 3 m3, separately fed with anaerobic supernatants from cattle and swine wastewater, both pure and added with dairy waste. The results showed N removal between 80 and 90%, for each matrix, while the monitoring of the kinetic parameters Kn and Kd confirmed the nitrites pathway, with stable NO2-N contributions of 90%. The numerical values of Kn and Kd were about three times the typical values of conventional biological processes, but a variation with the influent wastewater change was observed: basically the parameters reduced at lower ammonia nitrogen NH4-N influent load. Also, the effluent characterisation determined total phosphorous P removal of 72%, with COD and TSS reductions between 60 and 70%. The continuous monitoring of the gaseous emissions, expressed as % of the influent NH4-N, identified the almost absence of nitrogen dioxide (NO2), and amounts of nitrous oxide (N2O) and nitric oxide (NO) lower than 0.011% and 0.009% respectively. Data highlighted that emissions increased with the higher NO2-N concentration in the liquid phase, linked to greater NH4-N influent loads. Moreover, the polishing performance of the microalgae Scenedesmus Obliquus, immobilized in calcium alginate spheres, was evaluated on fluidised and packed bed photobioreactors, continuously fed, without air or CO2 addition. The results highlighted N and P removals on the average equal to 95%. In addition, once the treatment maximum capacity of the beads was reached, the separation of the algal biomass from the liquid effluent, for its reuse, was easily achieved.
Minervini, Mirko. "Ottimizzazione e/o vie alternative per il recupero e la gestione di nichel in reflui da impianto d' idrogenazione." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016.
Find full textMolinari, Riccardo. "Rimozione dei composti azotati nel Bacino 1 di affinamento reflui urbani trattati dal depuratore Santerno di Imola.Verifiche su impianto pilota." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017.
Find full textMANTOVANI, MARCO. "Nanoparticles for the removal of contaminants from wastewaters." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/305614.
Full textThis thesis is part of PerFORM WATER 2030 (Platform for Integrated Operation Research and Management of Public Water towards 2030), a project financed by the Lombardy region and the European Regional Development Fund. The objective is to produce laboratory-scale zero valent iron nanoparticles encapsulated in a carbonaceous matrix (ME-nFe), a material with reducing properties and high adsorption capacity that can be used in wastewater treatment. The synthesis of the nanoparticles is achieved through hydrothermal carbonization (HTC) starting from microalgal biomass grown in the pilot plant located at the Bresso-Niguarda (MI) treatment plant. Specifically, the first phases of work focused on collecting biomass directly from the plant and on its characterization in terms of elemental composition and polyphenol content. Subsequently, the conditions that could influence the synthesis of ME-nFe were studied: two types of salt were tested as an iron source (ammonium iron sulphate and iron nitrate), four Fe/C ratios to be put in the reactor (0.02, 0.05, 0.1, 0.2) and three different temperatures of the synthesis process (180°C, 200°C and 225°C). The characterization of the produced nanoparticles in terms of zero-valent and total iron content, specific surface area and nanoscale morphological structure, allowed the selection of the prototypes with the best properties. Once the best operating conditions were identified, the ME-nFe were tested in the removal of five heavy metals (Zn, Cu, Ni, Cd, Cr), first under ideal conditions and then in more realistic ones. At the end of the treatment, the possibility of recovering the CE-nZVI and reusing it them for multiple removal cycles was also assessed. The best results were achieve using a sorbent concentration of 3 gL-1 on a starting solution of the five heavy metals with a starting concentration of 1 mg L-1. The removal for Zn, Cu, Ni e Cd were higher than 96%. However, Cr was never affected during the tests. Hereafter, the toxicity of the liquid by-product of the HTC process was studied, both towards Aliivibrio fischeri, a luminescent bacterium used as an indicator in ecotoxicology, and towards the microalgae themselves. Microtox Basic tests were performed on the raw liquid by-product, showing a very strong effect even on very diluted samples (EC50= 1.8% after 15 min). The test was than repeated after a pretreatment step (precipitation of dissolved iron after pH adjustment) but the final toxicity was still very high, proving that the problem was not the dissolved iron but probably the presence of some toxic organic compounds (EC50= 6.8% after 15 min). Adsorption with activated carbons (using two different adsorbent doses of 2 and 3gL-1) was then performed as an alternative pretreatment. Both concentrations were able to sensibly reduce the wastewater toxicity, with the best result achieved using the 3gL-1 dose (EC50= 60% after 15 min). Finally, the possibility of cultivating microalgae on a dilution of the HTC wastewater was assessed, in order to study their decontamination capacity and simultaneously evaluating the possibility of closing the cycle, enhancing the by-product and obtaining new biomass for other syntheses of CE-nZVI. Microalgae were grown on a 20% dilution of the liquid by-product using the centrate as the diluent, both in batch and continuous mode, making the process to produce the microalgal base nanoparticles more sustainable.
Campani, Martina. "Biogas energy recovery from high salinity pickling tannery wastewater in UASB two-phase reactors." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018.
Find full textAndrade, Júlia Barone de. "Efeito do refluxo duodenogástrico no esmalte dental." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/58/58133/tde-14052015-090110/.
Full textThe goal of this study was to evaluate the effects of stomach and duodenal fluid on the enamel surface, simulating the action of refluxed liquid in patients with duodenogastric reflux. Forty bovine incisors were selected in order to obtain enamel fragments measuring 4x4x2mm each, which were then polished and brought to a microhardness test, where 40 final specimens were selected. The specimens were isolated with composite exposing only half of the enamel surface to erosive challenges and then randomly divided into 4 groups (n = 10), G1: HCl (pH 2.0); G2: HCl + pepsin (pH 2.1); G3: HCl + Ox Bile + NaHCO3 (pH 3.0); G4: HCl + Pancreatin + NaHCO3 (pH 3.0). The samples were exposed in 37°C solutions, 6 times a day, for 20 seconds, under stirring for 5 days. Subsequently, they were analyzed for morphologic evaluation, surface roughness and the step formed on the dental enamel, with confocal laser microscopy. The specimens were then cut longitudinally, their surfaces flattened and polished for holding the longitudinal microhardness, where 15 measurements were performed in each of the areas (control/protected and exposed). The data were analyzed using the Kruskal-Wallis test and Dunn\'s (p<0.05) means for differentiating. Both analysis showed a higher step and surface roughness for the G3 (5.59 ± 1.69, 2.2 ± 1.61), a difference that was statistically significant within groups 1 and 2 (3.9 ± 1, 55, 1.02 ± 0.18, 3.67 ± 1.45, 0.89 ± 0.12) (p <0.05) and only the step in G4 (4.9, ± 1.8) was similar to G3 (P> 0.05). The analysis of microhardness showed no statistically significant difference between groups. Morphological analysis showed greater structural loss in groups 3 and 4 with intense erosion of interprismatic region with amorphous areas. Therefore, it can be concluded that bile and pancreatin, from duodeno, in combination with hydrochloric acid, may promote greater dental erosion, with greater loss of structure, increased surface roughness and loss of enamel prismatic anatomy.
Oliveira, Andrea Dean de. "Parametros da monitorização do pH intra-esofagico em diferentes apresentações clinicas da doença de refluxo gastroesofagico." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309092.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: Na faixa etária pediátrica, a apresentação clínica da doença do refluxo gastroesofãgico é bastante inespecífica, dificultando o diagnóstico clínico da doença. A monitorização prolongada do pH intra-esofágico determina a freqüência e duração dos episódios de refluxo ácido para o esôfago, mas, em crianças acima de 2 anos, a relação entre os valores do índice de refluxo e as diferentes apresentações clinicas da doença de refluxo gastroesofãgico tem sido pouco avaliada. O presente estudo pretendeu identificar os resultados dos estudos prolongados do pH intra-esofágico e associá-los ao quadro clinico dos pacientes. A apresentação clínica foi dividida em quatro grupos, de acordo com a sintomatologia predominante: regurgitador, digestivo, respiratório e portadores de paralisia cerebral. A pesquisa desenvolveu-se por meio de estudo transversal, retrospectivo e analítico, através do levantamento dos resultados de monitorizações prolongadas do pH intra-esofágico realizadas no Hospital de Clínicas da Unicamp, no período de janeiro de 1999 a dezembro de 2004. Análises descritivas e de associação foram realizadas, foi utilizado o teste Qui Quadrado de Pearson ou Exato de Fisher. Os dados clínicos de 131 pacientes (1 a 20,6 anos) e seus respectivos exames foram revisados. Os motivos que mais freqüentemente determinaram a investigação laboratorial foram: vômitos, anemia, baixo ganho ponderal e pneumonias de repetição. Encontrou-se que 89 (67,9%) dos pacientes tinham um estudo de pHmetria anormal, mas no grupo regurgitador, o exame foi alterado em apenas 4 de 18 pacientes. Nenhuma das queixas clínicas esteve associada a valores de índice de refluxo > 4. Não houve associação significativa entre presença de esofagite péptica diagnosticada pela endoscopia digestiva alta e o valor do índice de refluxo. A distribuição dos valores de índice de refluxo em MPE não guardou relação com a manifestação clínica ou a presença de esofagite num grupo de crianças avaliadas em hospital universitário
Abstract: A diversity of symptoms may be attributed to gastroesophageal reflux disease in children. A 24-h pH monitoring of the lower esophagus identifies frequency and duration of the acid reflux episodes, but the association between symptoms of gastroesophageal reflux and pH-monitoring data has been investigated in few studies involving children. This study aimed to identify data of the pH-monitoring studies in children and correlate them to the clinical picture. Data of pH-monitoring studies performed from January 1999 to December 2004 in a Medical School Hospital were analyzed. Patients were classified into four groups according to their predominant clinical symptom: infant regurgitation, digestive symptoms, respiratory symptoms and cerebral palsy. Clinical data and pH-monitoring reports from 131 patients (1 to 20.6 years) were analyzed. The most frequent reasons for laboratorial investigation were vomiting, anemia, poor weight gain and recurrent pneumonia. It was found that 89 (67.9%) patients had an abnormal pH-metry study, although only 4 of 18 patients in the regurgitation group. No clinical group was related to reflux index >4. There was no significant association between peptic esophagitis, confirmed by upper digestive endoscopy, and reflux index. In this group of children reflux inex were not associated to clinical presentation or to upper digestive endoscopy data
Mestrado
Pediatria
Mestre em Saude da Criança e do Adolescente
Vicente, Alessandra Maria Borges. "Revisao da fundoplicatura de nissen para tratamento da doença do refluxo gastroesofagico em crianças e adolescentes." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309096.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: Doença do refluxo gastroesofágico, em crianças, pode causar prejuízos nutricionais, doença respiratória, alterações neurocomportamentais e inflamação esofágica. O tratamento desta doença requer medidas posturais, orientação alimentar e terapia medicamentosa. O tratamento cirúrgico está indicado para pacientes com doença do refluxo gastroesofágico crônica, associada ou não a complicações. A fundoplicatura é indicada, em substituição ao uso contínuo dos inibidores de bomba de prótons, para pacientes que não respondem ou respondem apenas parcialmente ao tratamento medicamentoso e quando há recorrência dos sintomas com a descontinuação das medicações. No pós-operatório pode ocorrer desmanche da válvula e recorrência da doença de refluxo, sugerindo a necessidade de monitorização da condição cirúrgica. A avaliação do funcionamento da válvula, baseada apenas nos sintomas dos pacientes, tem se mostrado insuficiente para essa monitorização. O objetivo desse estudo foi identificar a freqüência de anormalidades na válvula anti-refluxo e a freqüência de complicações pépticas do esôfago no pós-operatório tardio de fundoplicatura em crianças. Em estudo transversal e descritivo, foram selecionados 45 pacientes que realizaram fundoplicatura de Nissen num período de 12 a 30 meses prévios à avaliação. O estudo foi conduzido de maio de 2004 a fevereiro de 2007, no Hospital de Clínicas da Universidade Estadual de Campinas, onde todas as cirurgias foram realizadas. A faixa etária dos pacientes avaliados variou de 16 meses a 16,9 anos. Endoscopia digestiva alta foi o instrumento utilizado para verificar o aspecto da fundoplicatura e o do esôfago, além de permitir a coleta de amostra para estudo histológico. Dos 45 pacientes avaliados, 26 (57,8%) eram encefalopatas crônicos. Válvula anti-refluxo bem posicionada e configurada foi encontrada em 41 (91,1%) pacientes. A fundoplicatura foi efetiva no tratamento do processo inflamatório esofágico, mesmo quando havia subestenose ou estenose de esôfago associadas no pré-operatório. Contudo, complicações foram identificadas: esofagite péptica em 6 dos 45 pacientes e necessidade de nova fundoplicatura em dois pacientes. Esofagite péptica associou-se, com significância estatística, à presença de anormalidades na válvula anti-refluxo (p=0,005, teste exato de Fisher). Durante o estudo foram diagnosticados dois pacientes com diagnóstico de esôfago de Barrett. Os resultados permitem concluir que a endoscopia digestiva alta realizada no período pós-operatório tardio de fundoplicatura para doença do refluxo gastroesofágico em crianças permite avaliar a condição da válvula anti-refluxo e diagnosticar a presença de complicações
Abstract: Gastroesophageal reflux disease in childhood may cause nutritional impairment, esophagus inflammation, respiratory disorders and neurobehavioral alterations. In most cases, treatment includes postural, dietary and medical therapy. Anti-reflux surgery is recommended to patients who do not present improvement with proton pump inhibitors treatment, or present recurrence of symptoms when medical therapy is discontinued. Fundoplication surgery failed has been detected and it has been showed that wrap condition needs monitoring and that clinical symptoms are not sensitive enough to indicate fundoplication efficacy. The objective of this study was to identify the frequency of defective wrap in the late postoperative period and evaluate esophageal complications related with gastroesophageal reflux recurrence in children. The study was cross sectional and descriptive, by selecting 45 patients who had undergone Nissen fundoplication, 12 to 30 months before. All procedures were done at the Hospital de Clínicas da Universidade Estadual de Campinas, in the period from May 2004 to February 2007. The age range at post-surgery examination varied from 16 months up to 16.9 years. Upper gastrointestinal endoscopy was used to determine esophageal endoscopic and histopathologic appearance and fundoplication condition. In the evaluated sample, 26 patients (57.8%) were neurologically disabled. Intact wrap was identified in 41 patients (91.1%). The fundoplication was effective for treating esophagitis, even in patients with esophagus stenosis. However, some complications were identified: peptic esophagitis in 6 of 45 patients and a second fundoplication was necessary in 2 patients. Peptic esophagitis in the endoscopic evaluation was associated with defective wrap (p=0.005, Fisher¿s exact test). Two patients with Barrett esophagus were identified, during study. We conclude that endoscopic follow up may be useful for patients who underwent anti-reflux surgery. Endoscopy allows the diagnosis of possible complications
Mestrado
Pediatria
Mestre em Saude da Criança e do Adolescente
Lo, Piccolo Salvatore. "La digestione anaerobica dei fanghi prodotti dal depuratore di Savignano sul Rubicone: elaborazione dei dati sperimentali di impianto e simulazione del processo tramite il modello ADM1." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
Find full textÖzer, Aylin Coşkun Döner Fehmi. "Deneysel mide içeriği sıvısının tavşan burun ve paranazal sinüslerine etkisi /." Isparta : SDÜ Tıp Fakültesi, 2004. http://tez.sdu.edu.tr/Tezler/TT00136.pdf.
Full textBatista, Carlos Alexandre Gonçalves. ""Estudo clínico e endoscópico em pacientes com úlcera péptica gastroduodenal após 1 ano de erradicação do Helicobater pylori. Avaliação da relação entre o surgimento da esofagite erosiva e a cepa do Helicobacter pylori erradicado"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5147/tde-20092006-134022/.
Full textNowadays, there are many directrixes in literature as to the influence of Helicobacter pylori, in the Disease of Gastroesophagic reflux. Some authors believe that H. pylori could have a protective effect to the development of GERD, and others even conclude that the agent may be an aggravating factor in the disease. Many publications allert us to the development of symptoms of GERD, or even the esophagitis,in a reasonable percentage of erradicated patients by the triplicit scheme to treat H. pylori, and 10%, approximately, would have GERD. In fact, due to these doubts, a consensus has not been established yet to the importance of H. pylori in the GERDs etiopathogenic and its complications. The strains importance to the formation of esophagitis in patients submitted to erradication is another fact that has also been discussed. Maybe the most virulent ones, as the presence of pathogenical island(cagA) or some other vacuolating cytotoxin (vacA), would have a larger relation in the esophagitis prevention. Another important mechanism, pointed by many, to the formation of esophagitis in erradicated patients would be the elevation of Body Mass Index in this group of eradicated patients associated or not to the presence of hiatal hernia and justified by a better quality of life due to symptoms improvement after erradication. In our studies, 148 patients with active or healed peptic ulcer received triplicit scheme of erradication to the Helicobacter pylori and were submitted to endoscopic exams and histopathologic test of gathered samples by body and antro biopsies, respiratory test with carbon 14 and ureasis, before and after treatment. We have done the agent genotyping, through the PCR, separating samples of body and antro, to determine the agent Cepas. The patients have been followed ambulatorially for a year and evaluated as to the improvement or worsening of the symptoms related to GERD (pyrosis) and symptoms considered non-specific as epigastric pain; we have also tried to quantify the gain or loss of Body Mass Index. We found 28 patients(18.9%) with endoscopic erosive esophagitis (24 degree A and 4 degree B of Los Angeles) after agents treatment. In this group, only three patients who had no symptoms developed pyrosis (2%). Most of the patients benefitted from treatment showing that 69 (46.6%) presented improvement in pyrosis and another great majority improved non-specific symptoms. In 18 ulcered patients with esophagitis, the body analysis fragments was positive cagA (64.3%)and in antro samples of 21 were positive cagA (75%). As in the general group, the vacuolizing cepas slb/ml and slb were, respectivelly, the most found in the endoscopic esophagitis group. There was a slight raise in the BMI in patients with and without esophagitis, and it is, statistically more meaningful in the 120 patients without esophagitis. Even though there was the appearance of endoscopic erosive esophagitis in a reasonable number of patients, the symptmology was not a determining factor, because many have got better after the treatment, and erradication was not important to determine the erosive esophagitis. It was not found any relation between the agent genotyping and the development of endoscopic esophagitis. The raise of BMI does not justify in our study the esophagitis in ulcered patients treated against H. pylori.
Alves, Marilene Bargas Rodrigues. "Erosão dental em pacientes com doença do refluxo gastroesofágico." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/23/23139/tde-20012009-150512/.
Full textGastroesophagic reflux disease is a set of organic manifestations caused by gastric reflux to the esophagus. The association between Gastroesophagic reflux disease and dental erosion demonstrates the result of acid reflux. Dental erosion is defined as the irreversible loss of dental structure caused by a chemical process that does not involve bacterial action. This study evaluated Dental Erosion associated with Gastroesophagic reflux disease, according to age, sex and educational level in patients with an endoscopic diagnosis of esophagitis caused by gastroesophagic reflux using modified Savary-Miller classification, group (E) compared to patients without this diagnosis (endoscopically normal), a normal group (N), treated at Centro de Endoscopia Digestiva do Hospital Sírio-Libanês de São Paulo. 120 patients were examined, with ages ranging from 20 to 80 (average age 46.76), of both sexes presenting with an endoscopic diagnosis of esophagitis caused by gastroesophagic reflux, and a further 60 patients aged between 20 and 80 (average age 39.97) of both sexes not diagnosed with esophagitis caused by gastroesophagic reflux. Specific protocol was answered by the patient or their legal representative. The methodology adopted involved, in the first stage, an endoscopic examination of the upper digestive tract and a test for esophagitis caused by gastroesophagic reflux, diagnosed according to modified Savary-Miller classification. This was followed by an oral examination and dental erosion was classified when present in accordance with the Eccles and Jenkins Scale. For statistical analysis the results were tested for each variable using the Pearson Chi-square test (X²). The statistical results indicated that esophagitis caused by gastroesophagic reflux is a significant factor in the presence of dental erosion. Age is a significant factor in the presence of dental erosion, 49 years old group N and 59 years old group E. The male is a significant factor for not presence of dental erosion in the groups studied, other wise female is significant factor for not presence of dental erosion in the group N and not a significant factor in the group E. Educational level 3 was significant in the not presence of dental erosion. These results lead to the conclusion that patients who presented with dental erosion and a high degree of esophagitis caused by gastroesophagic reflux, 30 49 years old, and had a lower level of education.
Gören, İbrahim İşler Mehmet. "Gastroözofajial reflü hastalarında uzun dönem proton pompa inhibitörü kullanımının midede prekanseröz değişikliklerin gelişmesine etkisinin araştırılması /." Isparta : SDÜ Tıp Fakültesi, 2007. http://tez.sdu.edu.tr/Tezler/TT00330.pdf.
Full textPoliteo, Marco. "Performance of hybrid constructed wetland for piggery wastewater treatment." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3422597.
Full textL'impatto ambientale del settore zootecnico nel Nord-Est Italia colpisce direttamente l'acqua (accumulo di nitrati e eutrofizzazione). Le limitazioni introdotte dopo l’applicazione della Direttiva CE 91/676 si traducono spesso in un aumento della richiesta di superfici disponibili per la distribuzione dei reflui. In alcune zone, la carenza di terreni e l’elevato carico zootecnico hanno comportato un costo aggiuntivo che gli allevatori devono sostenere per potere disporre di terreni di altri agricoltori dove potere delocalizzare gli effluenti prodotti. Per valutare le possibilità applicative della fitodepurazione per il trattamento dell’azoto nella frazione liquida degli effluenti suini è stato condotto un monitoraggio di un impianto ibrido operante a scala aziendale. L’impianto ibrido di fitodepurazione occupa un’area di 130 m2, è costituito da tre vaschea flusso sub superficiale verticale (VF) operanti in parallelo seguite da una vasca a flusso sub superficiale orizzontale (HF). Durante la sperimentazione (2010-2012) le prestazioni dell’impianto di fitodepurazione sono state valutate variando: condizioni ambientali, concentrazioni e volumi in ingresso, modalità e tempi di carico e scarico delle vasche verticali. Nello specifico durante il primo periodo (Aprile 2010-Luglio 2010) il sistema è stato caricato con 5 m3/giorno di liquame pre-trattato. L’unità verticale ha funzionatocome “filtro biologico”. Nel secondo periodo (Ottobre 2010-Aprile 2011) il sistema è stato caricato con 5 m3/giorno di liquame non pre-trattato in modalità sequenziale batch, alternando fasi di “tutto pieno” e “tutto vuoto” grazie a un sistema di temporizzatori modulari pausa/lavoro a tempi indipendenti. Per valutare l’influenza delle basse temperature sui processi di rimozione dell’azoto, nel terzo periodo (Maggio 2011-Luglio 2012) il sistema è stato caricato con 1.7 m3/giorno di refluo ricostruito in modalitàsequenziale batch. Nel complesso, il sistema ibrido di fitodepurazione ha ridotto le concentrazioni in ingresso del COD dal 46 al 56%, del azoto totale dal 40 al 54%, del azoto ammoniacale dal 43 al 60%, del azoto nitrico dal 21 al 55%, del fosforo totale dal 32 al 35% e del ortofosfato dal 24 al 34%.
Canesin, Chiara. "La Short Rotation Forestry in Nord Italia. Limiti e potenzialità del suo impiego sotto differenti scenari: produzione di biomassa e prove di fertilizzazione." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3421881.
Full textNel corso dell’ultimo decennio la SRF da biomassa ha iniziato a diffondersi in Italia grazie alla presenza di cospicui finanziamenti. Al fine di evidenziare le reali potenzialità produttive e le problematiche della SRF realizzata in pieno campo in impianti produttivi non sperimentali è stata condotta un’analisi sincronica in 52 aree di saggio in impianti di SRF realizzati in pieno campo in Friuli Venezia Giulia. Sono stati analizzati il tasso di mortalità, l’emissione di getti dalla ceppaia a seguito della ceduazione, le principali caratteristiche dendrometriche e qualitative dei getti di due cloni di pioppo selezionati per la produzione di biomassa, Sirio e Pegaso, al fine di determinarne la produzione di biomassa e la sua relazione con le caratteristiche pedologiche. Al termine del primo ciclo colturale è stata registrata un produzione media di sostanza secca di 5 Mg ha-1 anno-1, e di 9 Mg ha-1 anno-1 al termine del secondo ciclo colturale, valori che risultano in linea con quelli evidenziati per piantagioni condotte con modelli colturali caratterizzati da bassi input o su terreni caratterizzati da limitata fertilità stazionale, mentre rese sensibilmente maggiori sono riportate per impianti soggetti a fertilizzazione ed irrigazione. È stata quindi condotta una seconda sperimentazione in un impianto di SRF in provincia di Cuneo composto da tre specie, pioppo, robinia e salice, testando tre differenti tipologie di spandimento di refluo zootecnico, apportando elevati quantitativi di nutrienti. Le rese in termini di biomassa sono risultate essere elevate, ma il pioppo non ha risposto ai trattamenti con un incremento significativo delle rese, probabilmente a causa di un eccesso di nutrienti. Il salice e la robinia hanno presentato un aumento della produzione di biomassa nei trattamenti con i reflui rispetto le prove non trattate, a dimostrazione che apporti di nutrienti possano influenzare positivamente la resa della SRF, senza ulteriori aggravi di costi.
Mendes, Thaís de Barros. "Monitorização prolongada do pH esofágico em recém-nascidos com menos de 1500 gramas com e sem displasia broncopulmonar = prevalência e fatores associados para resultados anormais do índice de refluxo." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310796.
Full textTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Recém-nascidos (RN) com displasia broncopulmonar (DBP) apresentam alta frequência de tratamento para doença do refluxo gastroesofágico (DRGE). O agravamento da evolução desta doença pulmonar é atribuído à associação entre as duas entidades. Em virtude das indefinições quanto à ocorrência da DRGE em RN com DBP e dadas as possíveis consequências sobre a sua morbidade, bem como as altas frequências de tratamento clínico, considerou-se ser de interesse estudar a presença de anormalidades da monitorização prolongada do pH esofágico em RN com e sem DBP. Objetivos- Determinar a prevalência de índice de refluxo (IR) ?10% na monitorização prolongada do pH esofágico em RNMBP com e sem o diagnóstico de DBP e estabelecer fatores associados. Métodos- Foi realizado um estudo prospectivo e de corte transversal com um componente longitudinal. Foram selecionados 35 casos com DBP e 15 sujeitos para o grupo de comparação que foram submetidos à monitorização prolongada do pH esofágico distal, no período de abril de 2004 a dezembro de 2008. Foram analisadas as variáveis demográficas, de evolução pós-natal, referentes a procedimentos e medicamentos no período neonatal, bem como os escores de gravidade clínica e radiológica da DBP e de gravidade da doença pulmonar na primeira semana de vida. Foram empregados os testes de Qui-quadrado e Exato de Fisher para as variáveis categóricas, e para as numéricas o teste U de Mann-Whitney. Em seguida foi realizada a análise por regressão logística univariada e múltipla para determinar o odds-ratio (OR) e o seu intervalo de confiança (IC) de 95%. Resultados- A prevalência de IR ?10% nos grupos com e sem DBP foi de 65,7% e 93,3%, respectivamente. O peso ao nascer foi o fator preditor independente de risco para o IR ?10% (OR 1,769 IC95% 1,172-2,669). Conclusão- Foi encontrada uma prevalência de IR ?10% em RN com DBP de 65,7% e no grupo de comparação de 93,3% sem sinais clínicos de DRGE. A chance de IR ?10% aumentou em 76,9% a cada aumento de 100 gramas no PN. Os resultados deste estudo permitem concluir que a prevalência de IR ?10% não é maior em RN com DBP do que no grupo de comparação. RN assintomáticos ou com apneia da prematuridade podem apresentar IR ?10%, sendo assim o diagnóstico de DRGE baseado nos resultados da monitorização do pH esofágico e a indicação de qualquer modalidade terapêutica precisa ser criteriosa até que se definam quais são os RN que necessitam de tratamento
Abstract: Neonates with bronchopulmonary dysplasia (BPD) present high frequency of treatment for gastroesophageal reflux disease (GERD). The relationship between these illnesses is controversy. Due to indefinations for ocorrency of GERD in newborns with BPD and considering the possible consequences about his morbidity so as the high frequency of clinical treatment, seems to us important to study the presence of abnormalities in the prolonged esophageal pH monitoring in neonates with and without BPD. Objectives- To determine the prevalence pH esophageal monitoring alterations in very low birth weight infants with and without BPD and establish associated factors for reflux index (RI) ?10%. Methods- A prospective, cross-sectional study, with a longitudinal component was realized, including 35 newborns with BPD and 15 subjects for the comparison group, that were submitted to 24 hours esophageal pH monitoring and studied from April 2004 to December 2008. Were evaluated variables demographics, postnatal evolution, procedures and medications used in the neonatal period, scores of clinical and radiologic severity and initial lung disease in the first week of life. For the statistic analysis were utilized the chi-square test and the Fisher's exact test for the category variables, and Mann-Whitney's test for numerical variables. Multiple logistic regression was used for to determine odds-ratio (OR) and confidence interval (CI) of 95%. Results- The prevalence of RI ?10% in the groups with e without BPD was 65.7% and 93.3%, respectively. The birth weight (BW) was the independent predictor factor for RI ?10% (OR 1.769 CI95% 1.172-2.669). Conclusions- High frequency of RI altered was demonstrated in newborns with BPD and the comparison group without clinics signs of GERD. The chance of RI ?10% increased in 76.9% in each increase of 100 grams in the BW. The results showed that the prevalence of RI ?10% not is major in neonates with BPD. Asymptomatic newborns or infants with apnea of prematurity may present IR ?10%, so the diagnosis of GERD based on the results of esophageal pH monitoring and indication of any therapeutic modality needs to be careful until a definition of which are infants who need treatment
Doutorado
Saude da Criança e do Adolescente
Doutor em Saude da Criança e do Adolescente
Duca, Ana Paula. "Deglutição em crianças com refluxo gastroesofágico: avaliação clínica fonoaudiológica e análise videofluoroscópica." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-23102006-214653/.
Full textGastroesophageal reflux is considered cause of infants feeding disorder. Negative experience such as vomiting, regurgitation; several times may be associated to choking, dysphagia and painfull swallowing produce aversion or feed refusal and causes a break up in the swallowing and feeding processes. This study evaluated the swallowing process in children with gastroesophageal reflux (GER), confirmed clinically and radiographically. We selected 37 children, with GER and GER complaints of feeding disorders, ages range from 7 months to 37 months, mean age of 15,4 months, consisted 25 males (67,6%) and 12 females (32,4%). The control group (GC) consisted of 15 healthy children (general and nourishing states), carefully chosen for not having any symptoms of GER, repetitive breathing disorders or developmental delays. The ages varied form 6 to 38 months, with mean age of 20,5 months, being 6 males (40%) and 9 females (60%). Swallowing evaluation (functional) considered three diets consistency: liquid, semi-solid and solid, beginning with 5 ml followed by free volume taken habitually by children. Free volume of milk and 5 ml of semi-solid, mixed with barium, were used during the videofluoroscopy. Children with GER presented alteration in clinical evaluations on 64,9% (n=24) and the control group on 13,3% (n=2), swallowing less diet solid diet, presents nausea, feeding refusal, choking and irritation. Videofluoroscopy evaluation for liquids, showed laryngeal penetration on 61,8 % (n =21) , GC 33,3% (n=5), and backward compensatory movement in 64,7% (n=22) e GC 0%, it was similar for the semi-solid diet 41,2% (n=14) e GC (n=0). There was no difference in time of the swallowing phases. This study shows that children with GER present difficulties to accepting feeding although no alteration on the oropharyngeal dynamics timing of swallowing was founded.
Corrêa, Maria Carolina Canteras Scarillo Falotico [UNESP]. "Avaliação dos parâmetros salivares de pacientes portadores da doença do refluxo gastroesofágico antes e após tratamento cirúrgico." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/101463.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Na doença do refluxo gastroesofágico (DRGE), o conteúdo gástrico pode retornar ao esôfago e atingir a cavidade oral, acarretando pequeno número de lesões cariosas e elevada incidência de erosões dentais. Sendo a saliva a principal responsável pela homeostase oral, a avaliação dos parâmetros salivares é imperiosa, numa tentativa de explicar este resultado. Os objetivos deste trabalho foram, analisar os parâmetros salivares (fluxo, pH e capacidade tampão da saliva), contagem de bactérias, índice de cárie e erosão dental em pacientes com a DRGE e avaliar o comportamento dos parâmetros salivares antes e após o tratamento cirúrgico dos indivíduos refluidores crônicos. Foram estudados 60 pacientes, sendo 30 com a DRGE (Grupo 1) e 30 controles (Grupo 2). A confirmação do diagnóstico da DRGE foi realizada através de exames endoscópico, manométrico e pH métrico do esôfago, realizados nos pacientes do Grupo 1. A endoscopia digestiva alta revelou esofagite em todos os pacientes, sendo 10 erosivas (33,3%) e 20 não erosivas (66,6%) e hérnia hiatal em 17 deles (56,6%). Os valores pressóricos no esfíncter inferior e superior do esôfago foram 10,75 + 2,42 mmHg e 75,24 + 28,08 mmHg respectivamente. O refluxo gastroesofágico foi observado em 25 pacientes do Grupo 1 (83,3%). O exame clínico revelou: erosões dentais: no Grupo 1, 141 faces dentárias com erosão comparado a 4 faces no Grupo 2, sendo a face palatina mais afetada (p<0,001), cárie dentária o Grupo 1 apresentou 41 dentes cariados e o Grupo 2, 156 (p<0,001). Os parâmetros salivares assinalados foram realizados nos pacientes dos grupos 1 e 2. O fluxo salivar estimulado no Grupo 1: 0,75 + 0,29 ml/min e no Grupo: 2: 0,78 + 0,52 ml/min (p=0,80); o pH salivar para o Grupo 1 foi 7,1 + 0,4 e no Grupo 2: 7,0 + 0,4 (p=0,85). A capacidade de tampão salivar dos pacientes com a DRGE apresentou valores mais baixos...
In the gastroesophageal reflux (GERD), the gastroduodenal content can leak back to the esophagus and reach the oral cavity causing some carious lesions and a high incidence of dental erosions. Salivary parameters evaluation is necessary to explain these results once saliva is the main cause of homeostasis. This paper aimed at analyzing the salivary parameters (flow and buffering capacity), bacteria count, erosion and tooth decay index in GERD patients. Sixty patients were studied: 30 GERD patients (group 1) and 30 the control group (group 2). Endoscopic, manometric, and pHmetric exams performed in the esophagus confirmed GERD in group 1 patients. High digestive endoscopy revealed esophagitis in all patients, being 10 erosive (33.3%) and 20 non-erosive (66.6%) and hiatal hernia in 17 of them (56.6%). Pressoric values in the lower and upper esophageal sphincter were 10.75 ± 2.42 mmHg, and 75.24 ± 28.08 mmHg respectively. Gastroesophageal reflux was observed in 25 patients of Group 1 (83,3%). The clinical exam showed: dental erosions: 141 erosion faces in Group 1 and 4 faces in Group 2 - the palatine face was the most affected (p<0.001); tooth decay: 41 decayed teeth in Group 1 and 156 in Group 2 (p<0.001). Salivary parameters were performed in both groups. Salivary stimulated flow rate in Group 1 was 0.75 ± 0.29 ml/min and in Group 2, 0.78 ± 0.52 ml/min (p=0.80); salivary pH in Group 1 was 7.1 ± 0.4 and in Group 2: 7.0 ± 0.4 (p= 0.85). GERD patients showed lower buffering capacity than the patients in the control group: 3.21 ± 0.7 and 3.7 ± 0.9 respectively (p= 0.018). GERD patients presented lower number of bacteria (Lactobacillus and Streptococcus) than the control group (p= 0.0067 and p= 0.0017 respectively). Non-stimulated salivary flow rate in GERD patients in the preoperative (0.26 ± 0.18) did not differ from the postoperative (0.29 ± 0.15; p=0.43). There was no ... (Complete abstract click electronic access below)
Corrêa, Maria Carolina Canteras Scarillo Falotico [UNESP]. "Efeitos do refluxo gastroesofágico na cavidade oral." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/86317.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação para o Desenvolvimento Médico e Hospitalar (Famesp)
A doença do refluxo gastroesofágico (DRGE) é uma infecção de elevada incidência no qual o refluxo gastroduodenal reflui para o esôfago e/ou orgãos adjacentes, inclusive a cavidade oral, podendo causar lesões ou nos tecidos duros e moles. Foram estudados 100 pacientes, sendo 50 portadores da DRGE (Grupo 1) e 50 controles...
Gastroesophageal reflux disease, or GERD is a high incidence condition in which gastro duodenal contents leak back, or refluz, into the esophagus and/or adjancent organs including the oral cavity and the therefore possibly causing lesions on the soft and hard tissue structures... (Complete abstract, click eletronic address below)
Ribeiro, Maxwel Capsy Boga 1982. "Avaliação de doentes portadores de doença do refluxo gastro-esofágico submetidos à fundoplicatura a Nissen modificada quanto a ocorrência de disfagia pós-operatória persistente." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311395.
Full textDissertação (mestrado profissional) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: A doença do refluxo gastroesofágico (DRGE) possui enorme relevância na sociedade, uma vez que é considerada a moléstia mais prevalente do trato digestivo superior. O entendimento de sua fisiopatologia, oriundo dos avanços propedêuticos, o surgimento de novas drogas eficazes na inibição da produção da secreção ácida gástrica, em níveis suficientes para a cicatrização de lesões esofágicas inflamatórias e a realidade da cirurgia videolaparoscópica contribuíram muito para o alívio da sintomatologia dos pacientes e em muitos casos para a cura das lesões causadas pelo refluxo gastroesofágico patológico. O tratamento cirúrgico videolaparoscópico é o grande avanço terapêutico nestes últimos anos, sendo que a sua indicação visa buscar a correção das alterações que levam ao surgimento da DRGE e com isso eliminar sintomas e curar as lesões esofágicas. Um grupo de 55 pacientes portadores de DRGE operados laparoscopicamente pela técnica de Nissen modificada, com e sem disfagia pré-operatória, foi avaliado clinica, manometrica, endoscopica, radiologica e cintilograficamente, antes da cirurgia. No período pósoperatório, estes pacientes foram estudados, com o intuito de pesquisar fatores de risco préoperatórios para o surgimento de disfagia pós-operatória persistente. O seguimento ambulatorial médio, após a cirurgia, foi de 47,5 meses. A idade destes pacientes variou de 25 a 74 anos, com média de 50 anos. O sexo feminino foi predominante com 50,91%. Houve associação estatística entre disfagia pré-operatória e disfagia pós-operatória, entre disfagia pós-operatória precoce (nas primeiras 6 semanas) e persistente (após 6 semanas). A dilatação esofágica endoscópica foi terapia segura e eficaz para pacientes disfágicos. Houve, também, associação estatística entre satisfação com a cirurgia e não necessidade de utilização de medicação antirefluxo após o procedimento, bem como entre satisfação com a cirurgia e ausência de disfagia pós-operatória persistente. Disfagia pré-operatória intensa foi fator de risco, com significância estatística, para ocorrência de disfagia pós-operatória persistente. Deste modo, este estudo conclui que uma anamnese minunciosa, para caracterização adequada dos pacientes candidatos a terapia cirúrgica para a DRGE, mesmo que subjetiva, através de consulta médica, foi mais importante que exames complementares, como a manometria esofágica, com dados aferidos objetivamente, para presunção de disfagia pós-operatória, que está diretamente relacionada com a satisfação do paciente, tanto quanto o controle efetivo dos sintomas, sem necessidade de uso regular de medicação
Abstract: Gastroesophageal reflux disease (GERD) is of great importance to society as it is considered to be the most common disease of the upper digestive tract. Understanding of the physiopathology of this disease as a result of advances in technology, the appearance of new drugs capable of reducing gastric acid secretions to levels low enough to enable healing of inflammatory esophageal lesions, the advent of videolaparoscopic surgery, have all contributed extensively to relieving the symptoms of patients and in many cases curing the lesions caused by gastroesophageal reflux. Surgical treatment by videolaparoscopic has been the major advance in surgery in the last few years, and its use seeks to correct the alterations that lead to the appearance of GERD, therefore eliminating the symptoms and curing esophageal lesions. A group of 55 patients with GERD operated laparoscopically by modified Nissen technique, with and without preoperative dysphagia, was evaluated clinically, manometrically, endoscopically, radiologically and with nuclear study before surgery. In the postoperative period, these patients were studied for researching risk factors for appearance of persistent postoperative dysphagia. The average follow-up after surgery was 47.5 months. The age of these patients ranged from 25 to 74 years, with an average of 50 years. The females were predominant with 50.91%. There was a statistical association between preoperative dysphagia and postoperative dysphagia, between early postoperative dysphagia (within 6 weeks) and persistent postoperative dysphagia (after 6 weeks). Esophageal endoscopic dilatation therapy was safe and effective for patients with dysphagia. There was also a statistical association between satisfaction with the surgery and no need for use of antireflux medication after the procedure, as well as between satisfaction with the surgery and no postoperative persistent dysphagia. Intense preoperative dysphagia was risk factor for postoperative persistent dysphagia. Therefore, this study concludes that evaluation of the candidates for surgical therapy for GERD, even though subjective, through anamnesis, was more important than exams, such as esophageal manometry, with data measured objectively, to presumption of postoperative dysphagia, which is directly related to patient satisfaction, as well as effective control of symptoms without the need for regular medication
Mestrado
Fisiopatologia Cirúrgica
Mestre em Ciências
Morais, Drausio Jeferson de. "Avaliação manométrica de doentes portadores de disfagia persistente após tratamento cirúrgico para a doença do refluxo gastroesofágico." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311384.
Full textTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: A doença do refluxo gastroesofágico (DRGE), tem grande importância na sociedade uma vez que é considerada como a doença mais comum do trato digestivo superior. O entendimento da fisiopatologia dessa doença decorrente dos avanços tecnológicos, o surgimento de novas drogas capazes de diminuírem a secreção ácida gástrica em níveis suficientes para levar a cicatrização de lesões esofágicas inflamatórias, o advento da cirurgia videolaparoscópica, contribuíram muito para o alívio dos sintomas dos pacientes e em muitos casos cura das lesões causadas pelo refluxo gastroesofágico. O tratamento cirúrgico por videolaparoscopia constituiu-se no grande avanço da cirurgia nestes últimos anos, sendo que a sua indicação visa buscar a correção das alterações que levam ao surgimento da DRGE e com isso eliminar os sintomas e curar as lesões esofágicas. Um grupo de 41 pacientes que tiveram disfagia persistente após fundoplicatura por videolaparoscopia foi estudado manometricamente, sendo que estes pacientes tinham no mínimo seis meses de cirurgia. A idade destes pacientes variou de 30 a 67 anos, com média de 48 anos. O sexo feminino foi predominante com 65,8%. Após criteriosa avaliação clínica, estes pacientes foram submetidos a exame radiológico contrastado do esôfago, endoscopia digestiva e manometria esofágica. Todos os pacientes tiveram cura da esofagite e apenas dois tinham um segmento curto de epitélio de Barrett. Outro grupo de pacientes, também submetidos a fundoplicatura à Nissen por videolaparoscopia, também com mais de 6 meses de cirurgia, mas sem disfagia tiveram a mesma avaliação. Este grupo também tinha distribuição etária e de sexo, semelhantes aos pacientes disfágicos. O grupo assintomático também mostrou no exame endoscópico, melhora total da esofagite. Os pacientes com disfagia mostraram alteração radiológica apenas em seis dos 41 analisados. O estudo manométrico deste grupo revelou alteração manométrica do corpo esofágico em 21 pacientes e com significância estatística em comparação com o grupo assintomático. Também os pacientes disfágicos, tiveram níveis de pressão residual em níveis mais elevados que o grupo controle, também em níveis significativamente maiores. A análise comparativa entre os pacientes assintomáticos e o grupo com disfagia permitiu concluir que, as alterações manométricas do corpo esofágico bem como a pressão residual contribuíram para a persistência da disfagia. Também, que a manometria esofágica no pré-operatório poderia contribuir para uma melhor avaliação destes pacientes, auxiliando na melhor conduta terapêutica. Também, que a manometria na avaliação dos pacientes disfágicos foi fundamental no entendimento das alterações que poderiam estar levando à este sintoma bem como a melhor conduta a ser tomada frente à esta alteração
Abstract: Gastroesophageal reflux disease (GERD) is of great importance to society as it is considered to be the most common disease of the upper digestive tract. Understanding of the physiopathology of this disease as a result of advances in technology, the appearance of new drugs capable of reducing gastric acid secretions to levels low enough to enable healing of inflammatory esophageal lesions, the advent of videolaparoscopic surgery, have all contributed extensively to relieving the symptoms of patients and in many cases curing the lesions caused by gastroesophageal reflux. Surgical treatment by videolaparoscopic has been the major advance in surgery in the last few years, and its use seeks to correct the alterations that lead to the appearance of GERD, therefore eliminating the symptoms and curing esophageal lesions. A group of 41 patients that suffered from persistent dysphagia after undergoing fundoplication by videolaparoscopic was manometrically studied, the patients having undergone surgery at least 6 months previously. The patients' ages ranged from 30 to 67 years, the average being 48 years. The female sex was predominant with 27 patients, the rest being masculine. After critical clinical diagnosis these patients were submitted to a contrasted radiological exam of the esophagus, digestive endoscopy and oesophageal manometry. All of the patients were cured of esophagitis and only 2 of them had a short segment of Barretts epithelium. Another group of patients also submitted to surgical treatment by videolaparoscopic Nissen technique, again having undergone surgery at least 6months previously, but without dysphagia received the same diagnosis. This group had a similar age and sex spread to the group of patients with disphagia. This asymptomatic group also showed healing of the erosive esophagitis in the endoscopic exam. The patients with dysphagia showed radiological alteration in only 6 of the 41 people analysed. The manometric study of this group revealed motor disorders of the esophageal body in 21 patients and with statistical relevance in comparison with the asymptomatic group. Also, the patients with dysphagia had residual pressure levels in more elevated levels than the control group, also in significantly greater levels. The comparative analysis between the asymptomatic patients and the group with dysphagia led to the conclusion that the manometric alterations of the esophageal body as well as the residual pressure contributed towards the persistence of the dysphagia. Also that the preoperative esophageal manometry could contribute towards a better diagnosis of these patients, helping with a better therapeutic approach. Also, that esophageal manometry in the diagnosis of patients with dysphagia was fundamental in the understanding of alterations that could be leading to this symptom as well as a better approach to be adopted in the face of these alterations
Doutorado
Fisiopatologia Cirúrgica
Doutor em Ciências
Joaquim, Adriana Iozzi. "Cistocintilografia direta cíclica no diagnóstico e caracterização do refluxo vesicoureteral em crianças e adultos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-24022015-150238/.
Full textIntroduction: The benefits of cyclic direct cystoscintigraphy (CD) for the diagnosis of vesicoureteral reflux (VUR) are poorly studied. The aim of this study was to investigate the influence of cyclic CD in children and adults and evaluate the classification and laterality of reflux, the total duration of the examination and of each cycle and the occurrence of reflux in the filling and/or voiding phases. Methods: A total of 362 examinations were performed in patients with a mean age of 15.8 ± 17.2 years (2 months to 76.4 years, 89.5% female). The examinations were divided into three groups: children younger than five years old (A), children older than five and younger than 14 (B) and patients older than 14 (C). Results: The distribution of the number of cycles in the CD examinations indicated that there were higher occurrences of two (37.6%) and three cycles (56.6%). VUR was diagnosed in 21% of patients based on the 1st cycle, 5.5% in the 2nd cycle and 2.5% only in the 3rd cycle. No examinations yielded additional VUR diagnoses with the 4th, 5th or 6th cycles. Most examinations showing VUR corresponded to grade II. Reflux occurred in only the filling phase in 10%, only the voiding phase in 27% and both phases in 63% of patients. There was a higher incidence of reflux in groups A and B than group C following the 1st cycle. The 2nd cycle was equally effective in diagnosing VUR in all three groups. In group A, the 3rd cycle was more effective compared to the other groups. There were no significant differences in the laterality of reflux. Conclusions: In group A, the examination duration was shorter, although there were more cycles and a greater diagnostic efficacy when a 3rd cycle was performed. The addition of a 2nd cycle was useful for diagnosing VUR in groups A and B, and the occurrence of VUR was higher in these age groups compared to adults. In group C, there was similar efficiency compared to others groups relative to the 2nd filling and voiding cycle; however, there were no benefits to adding a 3rd cycle
Corrêa, Maria Carolina Canteras Scarillo Falotico. "Efeitos do refluxo gastroesofágico na cavidade oral /." Botucatu : [s.n.], 2007. http://hdl.handle.net/11449/86317.
Full textAbstract: Gastroesophageal reflux disease, or GERD is a high incidence condition in which gastro duodenal contents leak back, or refluz, into the esophagus and/or adjancent organs including the oral cavity and the therefore possibly causing lesions on the soft and hard tissue structures... (Complete abstract, click eletronic address below)
Orientador: Maria Aparecida Coelho de Arruda Henry
Coorientador: Maria Cecília Veronezi
Banca: Mauro Masson Lerco
Banca: Roberto Heitzmann Rodrigues Pinto
Mestre
Jibb, Richard J. "Reflux condensation enhancement." Thesis, University of Manchester, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590632.
Full textCorrêa, Maria Carolina Canteras Scarillo Falotico. "Avaliação dos parâmetros salivares de pacientes portadores da doença do refluxo gastroesofágico antes e após tratamento cirúrgico /." Botucatu : [s.n.], 2010. http://hdl.handle.net/11449/101463.
Full textBanca: Mauro Masson Lerco
Banca: Luiz Eduardo Naresse
Banca: Roberto Heitzmann Rodrigues Pinto
Banca: Luiz Roberto Lopes
Resumo: Na doença do refluxo gastroesofágico (DRGE), o conteúdo gástrico pode retornar ao esôfago e atingir a cavidade oral, acarretando pequeno número de lesões cariosas e elevada incidência de erosões dentais. Sendo a saliva a principal responsável pela homeostase oral, a avaliação dos parâmetros salivares é imperiosa, numa tentativa de explicar este resultado. Os objetivos deste trabalho foram, analisar os parâmetros salivares (fluxo, pH e capacidade tampão da saliva), contagem de bactérias, índice de cárie e erosão dental em pacientes com a DRGE e avaliar o comportamento dos parâmetros salivares antes e após o tratamento cirúrgico dos indivíduos refluidores crônicos. Foram estudados 60 pacientes, sendo 30 com a DRGE (Grupo 1) e 30 controles (Grupo 2). A confirmação do diagnóstico da DRGE foi realizada através de exames endoscópico, manométrico e pH métrico do esôfago, realizados nos pacientes do Grupo 1. A endoscopia digestiva alta revelou esofagite em todos os pacientes, sendo 10 erosivas (33,3%) e 20 não erosivas (66,6%) e hérnia hiatal em 17 deles (56,6%). Os valores pressóricos no esfíncter inferior e superior do esôfago foram 10,75 + 2,42 mmHg e 75,24 + 28,08 mmHg respectivamente. O refluxo gastroesofágico foi observado em 25 pacientes do Grupo 1 (83,3%). O exame clínico revelou: erosões dentais: no Grupo 1, 141 faces dentárias com erosão comparado a 4 faces no Grupo 2, sendo a face palatina mais afetada (p<0,001), cárie dentária o Grupo 1 apresentou 41 dentes cariados e o Grupo 2, 156 (p<0,001). Os parâmetros salivares assinalados foram realizados nos pacientes dos grupos 1 e 2. O fluxo salivar estimulado no Grupo 1: 0,75 + 0,29 ml/min e no Grupo: 2: 0,78 + 0,52 ml/min (p=0,80); o pH salivar para o Grupo 1 foi 7,1 + 0,4 e no Grupo 2: 7,0 + 0,4 (p=0,85). A capacidade de tampão salivar dos pacientes com a DRGE apresentou valores mais baixos ... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: In the gastroesophageal reflux (GERD), the gastroduodenal content can leak back to the esophagus and reach the oral cavity causing some carious lesions and a high incidence of dental erosions. Salivary parameters evaluation is necessary to explain these results once saliva is the main cause of homeostasis. This paper aimed at analyzing the salivary parameters (flow and buffering capacity), bacteria count, erosion and tooth decay index in GERD patients. Sixty patients were studied: 30 GERD patients (group 1) and 30 the control group (group 2). Endoscopic, manometric, and pHmetric exams performed in the esophagus confirmed GERD in group 1 patients. High digestive endoscopy revealed esophagitis in all patients, being 10 erosive (33.3%) and 20 non-erosive (66.6%) and hiatal hernia in 17 of them (56.6%). Pressoric values in the lower and upper esophageal sphincter were 10.75 ± 2.42 mmHg, and 75.24 ± 28.08 mmHg respectively. Gastroesophageal reflux was observed in 25 patients of Group 1 (83,3%). The clinical exam showed: dental erosions: 141 erosion faces in Group 1 and 4 faces in Group 2 - the palatine face was the most affected (p<0.001); tooth decay: 41 decayed teeth in Group 1 and 156 in Group 2 (p<0.001). Salivary parameters were performed in both groups. Salivary stimulated flow rate in Group 1 was 0.75 ± 0.29 ml/min and in Group 2, 0.78 ± 0.52 ml/min (p=0.80); salivary pH in Group 1 was 7.1 ± 0.4 and in Group 2: 7.0 ± 0.4 (p= 0.85). GERD patients showed lower buffering capacity than the patients in the control group: 3.21 ± 0.7 and 3.7 ± 0.9 respectively (p= 0.018). GERD patients presented lower number of bacteria (Lactobacillus and Streptococcus) than the control group (p= 0.0067 and p= 0.0017 respectively). Non-stimulated salivary flow rate in GERD patients in the preoperative (0.26 ± 0.18) did not differ from the postoperative (0.29 ± 0.15; p=0.43). There was no ... (Complete abstract click electronic access below)
Doutor
Diemen, Vinícius von. "Hérnia hiatal e doença do refluxo gastroesofágico : estudo do colágeno na membrana frenoesofágica." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/139794.
Full textBackground: Gastroesophageal reflux disease (GERD) is defined by the intensity and/or quality of the reflux of gastric or duodenal contents into the esophagus. Surgical treatment of GERD has shown conflicting results and unacceptable recurrence rates, mainly due to herniation of the antireflux valve into the chest. A variety of techniques have been proposed to reduce GERD recurrence, including routine use of prosthesis in cruroplasty. The prevalence of GERD in patients with hiatal hernia (HH) can reach 94%. It is possible that the phrenoesophageal ligament (POL) engaged in the stabilization of the gastroesophageal junction in the abdomen may be an etiologic factor of HH. We conducted a study to evaluate collagen in the constitution of the POL in patients with HH and cadavers without HH. Methods: POL samples were collected from 29 patients with HH and GERD (cases) and 32 samples from cadavers without HH (controls). Total collagen was quantified through the Picro-Sirius histochemical technique, and type-I and type-III collagens were quantified immunohistochemically using a monoclonal antibody. The stained slides were photographed, and images were quantified by computer software (Image Pro Plus) to count the pixels per field. Results: The mean age was 49.5 (±11.5) years for the cases and 38.5 (±13) years for the controls (p < 0.01). Seventeen cases (58.6%) and 6 controls (18.75%) were female (p < 0.01). The quantity of total (p < 0.01), type-I (p < 0.01), and type-III (p < 0.05) collagen was significantly lower, about 60%, in patients with HH compared to controls. Conclusion: Our data indicate that the composition of POL for patients with GERD and HH has fewer total, type I and type III collagen than that of the POL of cadavers without HH. The quality of the POL may be an etiological factor in the development of HH.
Sakuno, Telma. "Contribuição da ultra-sonografia no diagnóstico da doença do refluxo gastroesofágico em crianças: estudo comparativo com pHmetria e histopatologia." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5151/tde-17102014-141710/.
Full textINTRODUCTION: Gastroesophageal reflux (GER) is an involuntary passage of the gastric content to the esophagus. Most of the time, it is considered a physiologic condition as it is very common on breast feeding babies and small children, however, it may determine clinical manifestations and lead to gastroesophageal reflux disease (GERD). The aim of this study was to evaluate ultrasonography as a mean of GERD diagnosis, comparing it with pH monitoring and histopathology in patients older than 2 years of age. METHOD: 45 children aged 2 to 14 years old were evaluated, who had been clinically suspected with GER were submitted to ultrasonography, pH monitoring and upper endoscopy with biopsy. Variables for this study were the presence of gastroesophageal reflux, angle of His measurement, length of intra-abdominal esophagus, time duration and frequency of GER, presence of oesophagitis and hiatus hernia. The statistical analysis measured the sensibility, specificity, positive and negative predictive values considering p<0.05. Logistic regression was applied to estimate GERD outcome and oesophagitis. RESULTS: Ultrasonography results showed sensibility of 91.7%, specificity of 61.9%, and positive predictive value of 73.3% and negative predictive value of 86.7% for the diagnosis of GERD when compared to pH monitoring. In the single variable analysis, the angle of His showed to be the predictor with best specificity for GERD and oesophagitis outcome, 71.4% and 72.7%, respectively. CONCLUSION: Ultrasonography showed to be a harmless exam with low costs and precise in the assessment of the esophagi-gastric junction, and its high sensibility and good specificity when compared to pH monitoring allows it to be performed in the early evaluation of children suspected with GERD
Rocha, Ilana Peliciari. "Imigração internacional em São Paulo: retorno e reemigração, 1890-1920." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/8/8137/tde-24102007-145107/.
Full textThis study about international immigration in São Paulo at the end of 19th century and the begining of 20th century has the purpose to approach the migrants reflow from remigration and from return. It shows the mentioned phenomenon with the international immigration movement perspective, as an important feature from a higher and dynamic movement and not only as a reflex of economic and social conditions from this place. The analysis was made based on the immigrants\'s profile in reflow, from the schedule on departures boarding lists from Santos in 1908 and the official reports from 1890 to 1920. The source allows to identify the destination, the nationality, the family laces, the ages, sex and the religions from these people. These characteristics were interpreted and linked to the economic and demographic conditionants, as well as the definite patterns from immigration history.
Camy, Lia Franco Serrou. "Estudo de associação da fisioterapia por aumento de fluxo expiratório e episódios de refluxo gastroesofágico em recém-nascidos prematuros com displasia broncopulmonar." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310793.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: A doença do refluxo gastroesofágico (DRGE) é considerada a doença esofágica mais comum no período neonatal, prolongando o tempo de internação de recém-nascidos (RN) nas unidades de tratamento intensivo neonatal. Apresenta-se frequentemente associada a todo tipo de manifestação respiratória, tanto em via aérea superior como no trato respiratório inferior. O efeito da fisioterapia respiratória sobre os episódios de refluxo, bem como a DRGE, é ainda um assunto não investigado em RNPT, e controverso nas demais faixas etárias. O objetivo do estudo foi determinar a associação da fisioterapia respiratória Aumento de Fluxo Expiratório (AFE) com episódios de refluxo ácido em prematuros com displasia broncopulmonar internados no Serviço de Neonatologia do CAISM. Os episódios de refluxo foram avaliados através da monitorização prolongada do pH esofágico e o diagnóstico de DRGE foi estabelecido pelas manifestações clínicas e pelo índice de refluxo ? 10%. Foram estudados os parâmetros da monitorização do pH antes e durante o procedimento da AFE em decúbito dorsal horizontal, na segunda e terceira horas de pós-prandial. Foram incluídos dezoito sujeitos randomizados em grupos de estudo, que receberam duas sessões de fisioterapia em dois momentos de pós-prandial Grupo 1 (n=9)-início do estudo pela segunda hora pós-prandial, Grupo 2 (n=9)- terceira hora de pós-prandial). O estudo foi experimental do tipo crossover. Para comparar as variáveis categóricas e as variáveis contínuas, entre os períodos (2ª e 3ª hora), foram utilizados, respectivamente, o teste exato de Fisher e o teste de U de Mann-Whitney. Para a comparação das variáveis numéricas entre os 2 períodos e entre as 2 avaliações (antes e durante a fisioterapia), foi utilizada a análise de variância (ANOVA) para medidas repetidas, seguida do teste de comparação múltipla de Tukey para comparar os grupos em cada momento, e o teste de perfil por contrastes para analisar a evolução entre avaliações, em cada período. O nível de significância adotado para os testes estatísticos foi de 5%. No grupo 1, na 2ª hora de pós-prandial, ocorreu redução significativa dos parâmetros da monitorização do pH durante a fisioterapia comparando-se com os 20 minutos prévios. No grupo 2 não houve diferença significativa entre os parâmetros da monitorização do pH antes e durante a fisioterapia, em nenhum dos períodos de pós-prandial analisados. A AFE, em decúbito dorsal horizontal, em prematuros com displasia broncopulmonar, com e sem DRGE, não determina aumento significativo do número e duração dos episódios de refluxo ácido, na segunda e terceira horas após a alimentação
Abstract: The gastroesophageal reflux disease (GERD) is considered the most common esophageal disease in the neonatal period, extending the period of hospitalization of newborns (NB) in the neonatal intensive care units. GERD often appears associated with all sorts of respiratory manifestation, both in the upper airway and lower respiratory tract. The effect of physiotherapy on the episodes of reflux and GERD is still an issue not investigated in preterm infants, and controversial in the other age groups. The aim of this study was to determine the association of respiratory therapy Increased Expiratory Flow (IEF) with episodes of acid reflux in premature infants with Bronchopulmonary Dysplasia hospitalized in the Neonatology Service of CAISM. Reflux episodes were evaluated by the esophageal pH monitoring and diagnosis of GERD was established by clinical symptoms and the reflux index ? 10%. The study also evaluated and compared the parameters of pH monitoring before and during the procedure of IEF, performed in supine position, in the second and third hour post-prandial. Eighteen subjects were randomized to receive either two sessions of physiotherapy at two post-prandial moments (Group 1-initiated study by the second postprandial hour, Group 2 - by the third hour post-prandial). The study was experimental crossover. To compare categorical variables and continuous variables between the periods (2nd and 3rd hour) it was used, respectively, the Fisher exact test and the U test of Mann-Whitney. For the comparison of numerical variables between the two periods and between the two assessments (before and during physical therapy) it was used the analysis of variance (ANOVA) for repeated measures followed by multiple comparison test of Tukey for the groups inside each moment, and the profile test by contrasts to examine the evolution of ratings for each period. The level of significance for statistical tests was 5%. In group 1, by the 2nd hour post-prandial, there was a significant reduction of the parameters of pH monitoring during therapy compared to the 20 minutes prior period. In group 2 no significant difference between the parameters of pH monitoring before and during therapy in any of the postprandial periods was observed. The AFE, in the supine position in preterm infants with bronchopulmonary dysplasia, with and without GERD, does not cause significant increase in the number and duration of acid reflux episodes in the second and third hour after feeding
Mestrado
Saude da Criança e do Adolescente
Mestre em Ciências
Pomiecinski, Fabiane. "Sensibilização a alérgenos alimentares na doença do refluxo gastroesofágico refratária ao tratamento convencional." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-24082010-161927/.
Full textAbstract: Refractory gastroesophageal reflux disease (GERD) can be related to greater sensitization to foods due to peptic acid damage to intercellular junctions and/or due to the increase in gastric pH by proton pump inhibitors (PPIs). The lack of response to treatment of GERD has been attributed to, among other causes, eosinophilic esophagitis (EE). Objective: The principal objective of the study was to evaluate the sensitization to foods in patients with refractory GERD. As secondary objectives, we compared the characteristics of sensitized patients with those non-sensitized and found a clinical response of GERD to a diet restricting foods to which the patient was sensitized. Methods: Patients with refractory GERD were put on a restriction diet based on the results of skin prick test (SPT) and atopy patch test (APT) with foods. The characteristics of the sensitized patients were compared to those non-sensitized in relation to atopia and number of eosinophils in the esophageal mucosa. Results: The prevalence of sensitization to foods in patients with refractory GERD was 27.7%, where 15.3% were determined by SPT and 12.3% by APT. Asthmatics showed higher sensitization to foods (p=0.008). The presence of eosinophils in the esophageal mucosa was determined in 15.8% of patients, and this correlated with greater sensitization to foods (p=0.011). One case of EE was confirmed. A diet excluding identified sensitizing foods led to clinical improvement with regard to GERD symptoms (p=0,004). Conclusion: The presence of eosinophils in esophageal mucosa associated with greater sensitization to foods and the response to restriction diet in patients with positive tests suggest that refractory GERD can represent an initial stage of EE.
Tatani, Solange Bernardes [UNIFESP]. "Parâmetros ecocardiográficos e peptídeo natriurético cerebral em pacientes no pósoperatório tardio de tetralogia de Fallot." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/9910.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Introdução e objetivos: as disfunções sistólica e diastólica do ventrículo direito, secundárias às lesões residuais após a correção cirúrgica da tetralogia de Fallot, contribuem para a morbidade e mortalidade no pós-operatório tardio. Embora estas lesões residuais possam ser avaliadas pela ecocardiografia Doppler, a relação entre os parâmetros ecocardiográficos e os níveis de proBNP (fragmento N-terminal do pró- BNP), um potencial biomarcador de sobrecarga ventricular direita, ainda não está bem estabelecida. Os objetivos do estudo foram analisar, em pacientes no pós-operatório de tetralogia de Fallot, a relação dos níveis plasmáticos de proBNP com parâmetros ecocardiográficos das dimensões das cavidades cardíacas direitas e da gravidade das lesões residuais, e os possíveis marcadores ecocardiográficos de níveis elevados de proBNP. Métodos: os níveis séricos de proBNP e os parâmetros ecocardiográficos foram obtidos no mesmo dia em 49 pacientes no pós-operatório tardio de tetralogia de Fallot (idade média de 14,7 anos, 51% do sexo feminino, com tempo médio de pós-operatório de 9,5 anos). Os parâmetros Doppler ecocardiográficos analisados foram: dimensões do átrio e ventrículo direitos, funções sistólica e diastólica ventricular direita e lesões pulmonares residuais. A relação entre estas variáveis e os níveis de proBNP foi analisada com testes de correlação de Pearson e análises uni e multivariada. Os valores de corte dos parâmetros ecocardiográficos preditores de níveis elevados de proBNP foram analisados pela curva ROC. Resultados: os níveis de proBNP estavam elevados em 53% dos pacientes e correlacionaram-se com o diâmetro diastólico do ventrículo direito (r= 0,41; p=0,003), com diâmetros longitudinal (r= 0,52; p=0,0001) e transversal (r= 0,47; p=0,001) do átrio direito, com o tempo de me0,41; p=0,005) e com o índice do refluxo pulmonar (r= -0,60; p<0,001). Pela análise multivariada o índice do refluxo pulmonar (R= -597; p=0,001; IC: -913,2 a -280,8) e o diâmetro longitudinal do átrio direito (R= 7,74, p<0,001; IC: 4,18 a 11,31) foram preditores independentes de proBNP elevado. Tempo de meia-pressão menor que 64 ms e índice do refluxo pulmonar menor que 0,65 apresentaram a melhor acurácia para indicar proBNP elevado. Conclusões: os níveis de proBNP podem estar elevados no pós-operatório tardio de tetralogia de Fallot e correlacionaram-se com as dimensões das câmaras direitas e com a gravidade do refluxo pulmonar. Valores de corte das dimensões das câmaras direitas e dos índices de gravidade do refluxo pulmonar podem se constituir em parâmetros úteis no seguimento dos pacientes no pós-operatório tardio de tetralogia de Fallot com lesão residual.ia-pressão da curva de velocidade do refluxo pulmonar (r= -
Background: Although the residual lesions after surgical correction of tetralogy of Fallot (TOF) can be evaluated by Doppler echocardiography (DE), the relation of DE parameters with the proBNP level, a potential biomarker of right ventricle overload, is not well known. The objective this study was to evaluate the DE parameters and their relation to proBNP levels. Methods: proBNP plasma level and Doppler echocardiography parameters were obtained in the same day in 49 patients later after repair of TOF (mean age of 14.7 years, 51% female, mean PO time of 9.5 years). The DE parameters studied were the dimensions of the right atrium (RA) and ventricle (RV), RV diastolic and systolic function and residual pulmonary lesions. The relation between them and proBNP levels were analyzed and the cutoff values of DE parameters for elevated proBNP determined. Results: proBNP was elevated in 53% and correlated with RV diastolic diameter (r=0.41; p=0.003), RA longitudinal (r=0.52; p=0.0001) and transversal (r=0.47; p=0.001) diameters, pressure half time of pulmonary regurgitation (PR) velocity (PHT) (r= -0.42; p=0.005) and the PR index (r=-0.60; p<0.001). By multivariate analysis the PR index (r=-597; p=0,001; CI: -913.2 to –280.8) and RA longitudinal (r=7.74; p<0,001; CI 4.18 to 11.31) were independent predictors of elevated proBNP. PHT lower than 64 ms (0.76) and PRi lower than 0.65 (0.81) had the best accuracy for elevated proBNP. Conclusion: proBNP may be increased in patients after surgical repair of TOF, correlated with the size of right cardiac chambers and the severity of PR.
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