Academic literature on the topic 'Reductive failure'

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Journal articles on the topic "Reductive failure"

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Sairam, Thiagarajan, Gobinath Shanmugam, Madhusudhanan Narasimhan, Meenu Subramanian, Amit N. Patel, Rajendran Gopalan, Ramalingam Sankaran, and Rajasekaran Namakkal Soorappan. "Evidence for Reductive Stress in the Heart Failure Patients." Journal of Molecular and Cellular Cardiology 112 (November 2017): 149–50. http://dx.doi.org/10.1016/j.yjmcc.2017.07.059.

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Benjamin, Ivor. "MITOCHONDRIAL-CYTONUCLEAR CROSSTALK AND OXIDO-REDUCTIVE STRESS IN HEART FAILURE." Free Radical Biology and Medicine 65 (November 2013): S10. http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.407.

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Shanmugam, Gobinath, Madhusudhanan Narasimhan, Silvio H. Litovsky, Jolyn Fernandes, Kevin Whitehead, John R. Hoidal, Thomas W. Kensler, Dean P. Jones, E. Dale Abel, and Namakkal-Soorapppan Rajasekaran. "Constitutive Activation of Nrf2 Causes Hyper-Reductive State and Heart Failure." Journal of Molecular and Cellular Cardiology 112 (November 2017): 150–51. http://dx.doi.org/10.1016/j.yjmcc.2017.07.061.

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David, Matthew, and Cynthia Meersohn Schmidt. "Power and Counter-Power: Knowledge Structure and the Limits of Control." Sociological Research Online 24, no. 1 (September 24, 2018): 21–37. http://dx.doi.org/10.1177/1360780418797717.

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In this article, we explore Susan Strange’s multidimensional and non-reductive international political economy (IPE) approach to structural power. Strange’s key weakness is the failure to account for her knowledge structure’s regulative form relative to her security, production and financial structures. We seek to develop Strange’s account through the addition of Manuel Castells’ account of digital network structures. Castells’ morphogenic structural approach to digital network power helps to clarify the mechanisms by which today’s knowledge structure achieves autonomy, internal regulation and generative capacity. This sociological completion of Strange’s theory, an international socio-political economy approach as it were, better explains the capacity and limits of today’s digital network knowledge structure to resist reduction to other structural interests. Strange’s non-reductive structural approach to power is significant for sociology as it helps identify ‘social order’ in a global age, but an additional sociological dimension is also necessary for the fulfilment of Strange’s theoretical project.
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Zhu, Siqi, Hongyang Sun, Hongjuan Geng, Deping Liu, Xu Zhang, Qing Cai, and Xiaoping Yang. "Dual functional polylactide–hydroxyapatite nanocomposites for bone regeneration with nano-silver being loaded via reductive polydopamine." RSC Advances 6, no. 94 (2016): 91349–60. http://dx.doi.org/10.1039/c6ra12100d.

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In bone tissue engineering, scaffolding materials with antibacterial function are required to avoid failure in treating infected bone defects, and poly(l-lactide) - hydroxyapatite nanocomposites containing silver nanoparticles are good choices for the purpose.
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Li, Yunlong, Baoying Wang, Yafeng Chang, Yuting Yang, Chunzhi Yao, Xinqi Huang, Jinbo Zhang, Zucong Cai, and Jun Zhao. "Reductive soil disinfestation effectively alleviates the replant failure of Sanqi ginseng through allelochemical degradation and pathogen suppression." Applied Microbiology and Biotechnology 103, no. 8 (February 15, 2019): 3581–95. http://dx.doi.org/10.1007/s00253-019-09676-4.

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Gwoździński, K., M. Janicka, J. Brzeszczyńska, and M. Luciak. "Changes in red blood cell membrane structure in patients with chronic renal failure." Acta Biochimica Polonica 44, no. 1 (March 31, 1997): 99–107. http://dx.doi.org/10.18388/abp.1997_4445.

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The properties of red blood cell membranes in patients with chronic renal failure were investigated using electron paramagnetic resonance spectroscopy. Using spin traps, 5,5-dimethylpirroline-1 oxide and N-tert-butyl-alpha-phenylnitrone, we found generation of hydroxyl radicals in the blood of patients with chronic renal failure after 20 min of regular hemodialysis. The physical state of membrane proteins and membrane osmotic fragility and reductive properties of red blood cells were studied. The increase in the relative correlation time of 4-(2-iodoacetamido)-2,2,6,6-tetramethylpiperidine-1 oxyl indicates the immobilization of membrane protein molecules in erythrocytes of chronic renal failure patients. The decrease in membrane protein mobility was observed in whole blood incubated with tert-butylhydroperoxide, regardless of the presence of iron. We found that the addition of ferrous ions did not aggravate profound changes in membrane proteins induced with tert-butylhydroperoxide. We also demonstrated higher osmotic fragility of erythrocytes in the patients with renal failure as compared to normal subjects. These alterations in membrane structure of red blood cells in hemodialysed patients suggest that hydroxyl radicals generated during hemodialysis can play an important role in the oxidative mechanism of erythrocyte damage.
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Meyer, R. G., W. Herr, A. Helisch, P. Bartenstein, and I. Buchmann. "Radioimmunotherapy for treatment of acute myeloid leukaemia and myelodysplastic syndrome." Nuklearmedizin 44, no. 03 (2005): 107–17. http://dx.doi.org/10.1055/s-0038-1625714.

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SummaryThe prognosis of patients with acute myeloid leukaemia (AML) has improved considerably by introduction of aggressive consolidation chemotherapy and haematopoietic stem cell transplantation (SCT). Nevertheless, only 20-30% of patients with AML achieve long-term diseasefree survival after SCT. The most common cause of treatment failure is relapse. Additionally, mortality rates are significantly increased by therapy-related causes such as toxicity of chemotherapy and complications of SCT. Including radioimmunotherapies in the treatment of AML and myelodyplastic syndrome (MDS) allows for the achievement of a pronounced antileukaemic effect for the reduction of relapse rates on the one hand. On the other hand, no increase of acute toxicity and later complications should be induced. These effects are important for the primary reduction of tumour cells as well as for the myeloablative conditioning before SCT.This paper provides a systematic and critical review of the currently used radionuclides and immunoconjugates for the treatment of AML and MDS and summarizes the literature on primary tumour cell reductive radioimmunotherapies on the one hand and conditioning radioimmunotherapies before SCT on the other hand.
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Rajasekaran, Namakkal S., Matthew A. Firpo, Brett A. Milash, Robert B. Weiss, and Ivor J. Benjamin. "Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice." Physiological Genomics 35, no. 2 (October 2008): 165–72. http://dx.doi.org/10.1152/physiolgenomics.00297.2007.

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Protein aggregation cardiomyopathy is a life-threatening manifestation of a multisystem disorder caused by the exchange mutation in the gene encoding the human small heat shock protein αB-crystallin (hR120GCryAB). Genetic studies in mice have established cardiac hR120GCryAB expression causes increased activity of glucose 6-phosphate dehydrogenase (G6PD) and “reductive stress” (Rajasekaran et al., Cell 130: 427–439, 2007). However, the initiating molecular events in the pathogenesis of this novel toxic gain-of-function mechanism remain poorly defined. In an integrated systems approach using gene expression profiling, we identified a “biosignature,” whose features can be validated to predict the onset, rate of progression, and clinical outcome of R120GCryAB cardiomyopathy. At the 3 mo disease-related but compensated stage, we demonstrate that transcripts were only upregulated in three distinct pathways: stress response (e.g., Hsp70, Hsp90), glutathione metabolism (Gpx1, Gpx3, glutathione S-transferase), and complement and coagulation cascades in hR120GCryAB transgenic mouse hearts compared with either hCryAB WT transgenic mice or nontransgenic controls. In 6 mo old myopathic hearts, ribosomal synthesis and cellular remodeling associated with increased cardiac hypertrophy were additional upregulated pathways. In contrast, the predominant downregulated pathways were for oxidative phosphorylation, fatty acid metabolism, intermediate metabolism, and energetic balance, supporting their primary pathogenic roles by which G6PD-dependent reductive stress causes cardiac decompensation and overt heart failure in hR120GCryAB cardiomyopathy. This study extends and confirms our previous findings that reductive stress is a causal mechanism for hR120G CryAB cardiomyopathy and demonstrates that alteration in glutathione pathway gene expression is an early biosignature with utility for presymptomatic detection.
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Kim, Myung Ji, So Hee Park, Keun Young Park, Hyun Ho Jung, Jong Hee Chang, Jin Woo Chang, Jae Whan Lee, and Won Seok Chang. "Gamma Knife Radiosurgery Followed by Flow-Reductive Embolization for Ruptured Arteriovenous Malformation." Journal of Clinical Medicine 9, no. 5 (May 2, 2020): 1318. http://dx.doi.org/10.3390/jcm9051318.

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Background: Aggressive treatment to achieve complete obliteration of brain arteriovenous malformation (AVM) is necessary in patients with a recent history of hemorrhage. The major drawback of Gamma knife radiosurgery (GKRS) alone for AVM is risk of bleeding during the latent period until the AVM occludes. At our center, patients who present with ruptured AVMs are frequently offered GKRS followed by embolization. The goal of this study was to compare outcomes of embolization for patients who have previously undergone GKRS for ruptured AVMs. Methods: A database including 150 GKRS for ruptured AVMs between November 2008 and October 2017 was reviewed. The embolized group was selected by including AVMs with post-GKRS embolization. The non-embolized group was defined as AVMs treated by GKRS alone. Outcomes including obliteration rate, incidence of repeat hemorrhage, and delayed cyst formation were compared between two groups. The predictive factors related to AVM obliteration and complications were analyzed. Results: The study consisted of 81 patients in the non-embolized group and 17 patients in the embolized group. Statistically significant differences were detected between the two groups with respect to age, Pollock-Flickinger score, Spetzler-Martin (SM) grade, eloquence of adjacent brain, and presence of aneurysms. The embolized group included more AVMs with larger median nidus volume. The predictive factors for the obliteration of ruptured AVMs were nidus volume, SM grade, Virginia Radiosurgery AVM Scale (VRAS), and Pollock-Flickinger score and for the subsequent hemorrhage were marginal dose, nidus volume, SM grade, VRAS, and Pollock-Flickinger score. The obliteration rates and complication rates after GKRS between groups were not significantly different. However, this study demonstrated statistically significant difference in the cumulative incidence of obliteration in AVMs with SM grade III and IV (p = 0.037). Conclusion: Although the current study demonstrated similar results in patients who underwent GKRS with and without embolization, the embolized group included more AVMs with larger nidus volume, higher SM grade, Pollock-Flickinger score, and aneurysm, which have a lower chance of obliteration and a higher probability of repeat hemorrhage. GKRS followed by embolization appears to be a beneficial approach for the treatment of ruptured AVMs that are at risk for obliteration failure and repeat hemorrhage during the latency period after single-session GKRS alone. Further studies involving a larger number of cases and continuous follow-up are necessary to confirm our conclusions.
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Dissertations / Theses on the topic "Reductive failure"

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Kitto, Kirsty, and Kirsty Kitto@flinders edu au. "Modelling and Generating Complex Emergent Behaviour." Flinders University. School of Chemistry, Physics and Earth Sciences, 2006. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20060626.132947.

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Despite a general recognition of the importance of complex systems, there is a dearth of general models capable of describing their dynamics. This is attributed to a complexity scale; the models are attempting to describe systems at different parts of the scale and are hence not compatible. We require new models capable of describing complex behaviour at different points of the complexity scale. This work identifies, and proceeds to examine systems at the high end of the complexity scale, those which have not to date been well understood by our current modelling methodology. It is shown that many such models exhibit what might be termed contextual dependency, and that it is precisely this feature which is not well understood by our current modelling methodology. A particular problem is discussed; our apparent inability to generate systems which display high end complexity, exhibited by for example the general failure of strong ALife. A new model, Process Physics, that has been developed at Flinders University is discussed, and arguments are presented that it exhibits high end complexity. The features of this model that lead to its displaying such behaviour are discussed, and the generalisation of this model to a broader range of complex systems is attempted.
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Farrahi, Geeti. "Transition of Care Guideline for Reducing Heart Failure Hospital Readmission." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5331.

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Heart failure (HF) patients are among the populations with the highest rates of hospital readmission within 30 days of discharge. Because of the 2010 Health Care Reform legislation, healthcare organizations are subject to financial penalty when a patient population exhibits excess readmissions. A significant reason for readmission of HF patients is a gap in the transition of care from hospital to home. The purpose of this doctoral project was to develop a practice guideline of best practices for transitioning HF patients from hospital to home. The transitional care model and care transitions intervention provided the theoretical underpinnings for developing this project. The research question explored whether a transition-of-care guideline would reduce hospital readmission for the HF population. The methodology used to develop the clinical practice guideline was derived from a synthesis of scholarly literature and evidence-based transitional care quality initiatives. Seven interdisciplinary experts involved in HF transition of care used the Appraisal of Guidelines Research and Evaluation II instrument (AGREE II) to assess the development of the practice guideline. The scores of 6 AGREE II domains were summed and scaled to obtain a percentage of the maximum possible score for each domain. Scores showed that the clinical practice guideline was rigorous, high quality, effective in improving transition of care, and has the potential to reduce HF readmission. Positive social changes resulting from this practice guideline include an improvement in patient outcomes, a reduction in readmission rates, and a reduction in the associated financial burden to the hospital.
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Chen, Quan. "Risk Management of Cascading Failure in Composite Reliability of a Deregulated Power System with Microgrids." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/52980.

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Due to power system deregulations, transmission expansion not keeping up with the load growth, and higher frequency of natural hazards resulting from climate change, major blackouts are becoming more frequent and are spreading over larger regions, entailing higher losses and costs to the economy and the society of many countries in the world. Large-scale blackouts typically result from cascading failure originating from a local event, as typified by the 2003 U.S.-Canada blackout. Their mitigation in power system planning calls for the development of methods and algorithms that assess the risk of cascading failures due to relay over-tripping, short-circuits induced by overgrown vegetation, voltage sags, line and transformer overloading, transient instabilities, voltage collapse, to cite a few. How to control the economic losses of blackouts is gaining a lot of attention among power researchers. In this research work, we develop new Monte Carlo methods and algorithms that assess and manage the risk of cascading failure in composite reliability of deregulated power systems. To reduce the large computational burden involved by the simulations, we make use of importance sampling techniques utilizing the Weibull distribution when modeling power generator outages. Another computing time reduction is achieved by applying importance sampling together with antithetic variates. It is shown that both methods noticeably reduce the number of samples that need to be investigated while maintaining the accuracy of the results at a desirable level. With the advent of microgrids, the assessment of their benefits in power systems is becoming a prominent research topic. In this research work, we investigate their potential positive impact on power system reliability while performing an optimal coordination among three energy sources within microgrids, namely renewable energy conversion, energy storage and micro-turbine generation. This coordination is modeled when applying sequential Monte Carlo simulations, which seek the best placement and sizing of microgrids in composite reliability of a deregulated power system that minimize the risk of cascading failure leading to blackouts subject to fixed investment budget. The performance of the approach is evaluated on the Roy Billinton Test System (RBTS) and the IEEE Reliability Test System (RTS). Simulation results show that in both power systems, microgrids contribute to the improvement of system reliability and the decrease of the risk of cascading failure.
Ph. D.
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Lyons, Kristopher Samuel. "Effect of HMG Co-A reductase inhibition on biological and ultrasound measures of endothelial function in human heart failure." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.602362.

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Heart failure (HF) is a clinical syndrome in which neurohormonal activation and cardiac remodelling occur in response to an index pathological event. Functional measures and biological markers of blood vessel function have been shown to be altered in HF, and abnormalities of microvascular function have been demonstrated in a variety of vascular beds. Treatment of HF involves medications which target abnormalities in the neurohormonal systems that regulate cardiovascular function, however the role of HMG Co-A reductase inhibitors (statins) in HF is unclear. Some observational and mechanistic studies have suggested benefit, however, results of prospective intervention trails have been disappointing. This thesis reports the vascular and biological abnormalities detectable in HF patients with systolic dysfunction compared to controls, and the vasular and biological effect of treatment with simvastatin in HF patients with systolic dysfunction. Treatment with simvastatin resulted in a significant reduction in Co Q IO levels in HF patients but not in coQ10ILDL ratio. There was a non-significant trend toward reduction in NT-proBNP levels. Other biomarkers studied were unchanged by treatment At baseline, differences between HF patients and controls were apparent in brachial artery flow mediated dilatation and doppler waveforms obtained from the retrobulbar circulation. No such differences were apparent in brachial artery waveforms. Treatment with simvastatin did not result in any change in doppler waveforms obtained from the retrobulbar circulation or brachial artery. Abnormalities in vascular function in HF are widespread and can be detected by novel wavelet analysis of doppler waveforms obtained from the retrobulbar circulation. 4 weeks of treatment with simvastatin did not produce improvements in measures of vascular function suggesting a lack of additional benefit over and above baseline treatment in this population at least over a short treatment period. Further research is required to see if longer periods of treatment may be effective .
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Sano, Takahiro. "Biomechanics of Fixation of Distal Radius Fractures: Comparison between Volar Plate Fixator (VPF) and Non-Bridging External Fixator (NBX)." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_theses/121.

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Fracture of the distal radius is one of the most frequent injuries, and it represents about 20% of all adults taken into emergency rooms. A number of studies suggest various methods to reduce the dislocation and to secure fragments of the distal radius. In this study, the Non-Bridging External Wrist Fixator System (NBX), a pre-market-released product manufactured by NUTEK Inc. was biomechanically assessed by comparing with the Universal Distal Radius System (Volar Plate Fixator: VPF), a market-released product manufactured by Stryker Co. The comparison was performed in several parameters, which were wrist motion, radial tilt angle, radial length, volar tilt angle, stiffness, and failure load. Five pairs of fresh human cadaver arms were used for this study. The wrists were tested to obtain x-ray images for 1 normal and 2 injury conditions (intact, fractured, and fixed), 2 load conditions (gravity only and torque applied), and 4 postural conditions (volar flexion, dorsiflexion, ulnar deviation, and radial deviation). These tests yielded 24 (3×2×4) x-ray images for each wrist, and the images were analyzed to obtain the data for each parameter. Although the results were not statistically significant in some conditions, NBX fixation limited wrist motion more than VPF fixation. This result can be explained not only by the difference in the ability of fixation, but also by the difference in the surgical trauma (NBX is less invasive than VPF). Furthermore, in the measurement of radial tilt angle, radial length, and volar tilt angle, NBX was more effective than VPF to reduce and secure the bone fragments of the distal radius. In destructive test, the NBX is less strong than VPF. However, NBX is strong enough to sustain the expected forces of daily activity.
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Zhang, Di. "Analysis and Design of Paralleled Three-Phase Voltage Source Converters with Interleaving." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/27579.

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Three-phase voltage source converters(VSCs) have become the converter of choice in many ac medium and high power applications due to their many advantages, including low harmonics, high power factor, and high efficiency. Modular VSCs have also been a popular choice as building blocks to achieve even higher power, primarily through converter paralleling. In addition to high power ratings, paralleling converters can also provide system redundancy through the so-called (N+1) configuration for improved availability, as well as allow easy implementation of converter power management. Interleaving can further improve the benefit of paralleling VSCs by reducing system harmonic currents, which potentially can increase system power density. There are many challenges to implement interleaving in paralleled VSCs system due to the complicated relationships in a three-phase power converter system. In addition, to maximize the benefit of interleaving, current knowledge of symmetric interleaving is not enough. More insightful understanding of this PWM technology is necessary before implement interleaving in a real paralleled VSCs system. In this dissertation, a systematic methodology to analyze and design a paralleled three-phase voltage source converters with interleaving is developed. All the analysis and proposed control methods are investigated with the goal of maximizing the benefit of interleaving based on system requirement. The dissertation is divided into five sections. Firstly, a complete analysis studying the impact of interleaving on harmonic currents in ac and dc side passive components for paralleled VSCs is presented. The analysis performed considers the effects of modulation index, pulse-width-modulation (PWM) schemes, interleaving angle and displacement angle. Based on the analysis the method to optimize interleaving angle is proposed. Secondly, the control methods for the common mode (CM) circulating current of paralleled three-phase VSCs with discontinuous space-vector modulation (DPWM) and interleaving are proposed. With the control methods, DPWM and interleaving, which is a desirable combination, but not considered possible, can be implemented together. In addition, the total flux of integrated inter-phase inductor to limit circulating current can be minimized. Thirdly, a 15 kW three phase ac-dc rectifier is built with SiC devices. With the technologies presented in this dissertation, the specific power density can be pushed more than 2kW/lb. Fourthly, the converter system with low switching frequency is studied. Special issues such as beat phenomenon and system unbalance due to non-triplen carrier ratio is explained and solved by control methods. Other than that, an improved asymmetric space vector modulation is proposed, which can significantly reduce output current total harmonic distortion (THD) for single and interleaved VSCs system. Finally, the method to protect a system with paralleled VSCs under the occurrence of internal faults is studied. After the internal fault is detected and isolated, the paralleled VSCs system can continue work. So system reliability can be increased.
Ph. D.
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Weiss, Dorothea. "PRIMUM NON NOCERE : Medicine's Culture of Dealing with and Denial of the Occurrence of Medical Harm." Thesis, Linköpings universitet, Centrum för tillämpad etik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-154396.

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The hippocratic principle "primum non nocere" (above all do no harm) has always been and still is the strong foundation of medical conduct. For a long time healthcare professionals created the image of infallibility of medicine. Even within the "closed" hierarchies mistakes and malpractice were never openly discussed. This paper first investigates reasons for medical mistakes and introduces the legislation when malpractice occurs. Secondly ethical questions concerning medical mistakes are discussed through the lens of Beauchamp and Childress' principles of biomedical ethics (nonmaleficence, beneficence, respect for autonomy, justice). Thirdly, an ethically defensible strategy to deal with failure and malpractice is proposed. This proposal stresses how to improve the patient-physician communication by involving patients' experiences in order to increase patient safety and lower costs in the healthcare system. In regard to tackling medical harm there is the strong recommendation to follow four directives: open disclosure and explanation, adequate restorative and/or compensatory actions, fair and square apologies and information about strategies to avoid recurrence.
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Bredin, Fredrik. "Passive volume reduction heart surgery using the Acorn cor cap cardiac support device /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-284-2/.

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Hommerding, João Daniel. "Aplicação e comparação de metodologias de projetos em grupos para resolução de problemas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/31408.

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Faz-se necessária, no ambiente industrial atual, a participação ativa dos colaboradores, proporcionando melhorias de processo / produto e correção de problemas. A utilização de metodologias de projetos em grupo para resolução de problemas, tais como os Círculos de Controle de Qualidade (CCQs), criados há mais de 40 anos, resulta na motivação dos colaboradores, por meio da melhoria do ambiente de trabalho e, consequentemente, de processos e de custo. Um dos objetivos deste estudo é verificar resultados que justifiquem, ou não, a continuidade da utilização do CCQ em uma empresa multinacional com unidade fabril no Brasil. Outro objetivo é comparar a metodologia CCQ com a metodologia Seis Sigma por meio da aplicação de um projeto piloto Seis Sigma nesta mesma empresa. Os resultados sugerem a continuidade do uso da metodologia CCQ na empresa analisada para resolução de problemas de baixa e média complexidades, com adoção de pequenas adequações fornecidas pela análise da metodologia Seis Sigma, além da adoção da metodologia Seis Sigma para condução de projetos de resolução de problemas complexos.
It is necessary in the current industrial environment, the active participation of employees, providing improvements in product / process and problem correction. The use of methodologies of group projects to solve problems, such as QCC (Quality Control Circle), established over 40 years, results in employee motivation by improving the work environment and, consequently, processes and costs. One purpose of this study is to verify results that would justify, or not, the continuing of the use of the QCC in a multinational company with manufacturing unit in Brazil. Another purpose is to compare the QCC methodology with the Six Sigma methodology by implementing a Six Sigma pilot project in the same company. The results suggest the continuing use of the QCC methodology in the analyzed company to solve problems of low and intermediate complexity, with the adoption of small adjustments provided by the analysis of Six Sigma beyond the adoption of Six Sigma methodology to conduct projects to solve complex problems.
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Madonsela, Alex Thulani. "A structured approach for the reduction of mean time to repair of blast furnace D, ArcelorMittal, South Africa, Vanderbijlpark / Madonsela A.T." Thesis, North-West University, 2011. http://hdl.handle.net/10394/7311.

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Organizations are expected by their shareholders to continually deliver above industry returns on capital invested and to remain competitive in the industry of choice through productivity, safety and quality. The maintenance function is a key area in which competitiveness through efficiencies and world–class performance can be attained by focusing on the prevention and reduction of long and costly equipment repair times. The question is: how can the mean time to repair of equipment already installed in the plant be reduced? To answer the above question correctly and comprehensively, the research explored mixed methods in finding answers. Quantitative methodology using a survey was used for data collection. Observations and interviews were held with maintenance personnel to uncover information that couldn’t have been obtained by means of a survey. The survey was limited to equipment performance measures, human factors, environmental factors, planning, spare parts, maintainability, procedures and training. To test consistency and accuracy of representation of the total population under study, a reliability test was done by using Cronbach’s alpha coefficient. To determine whether there are any differences between groups, an ANOVA test was used. Cohen’s d–value was used to determine practically significant differences between one set of data with another and correlation analysis was used to determine the relationships between the variables. The approach designed and delivered by this research flowed from the existing body of knowledge, case studies and survey findings. The approach adopts some of the elements of the failure mode and effects analysis (FMEA) procedure and differs from other work that has been done by others by taking into account the competency and experience of maintenance personnel and assigning to them factors which are used to compute anew MTTR of the equipment. The cost of implementing the recommended corrective actions for realising the new MTTR is determined and evaluated against an improved equipment availability that will be achieved as a result of the recommended corrective actions assuming that the failure rate of the equipment remains constant. This evaluation step imbedded within the approach is valuable for the maintenance function and management for decision making in ensuring that resources at the organization’s disposal are used productively. Validation and test results of the approach showed that the MTTR of equipment installed in the plant can be reduced. The results also indicated that through the use of the designed approach a regular pattern of repair or replacement times can be followed well in advance and that it is practical, user friendly and it also delivers on its objective of offering a structure for analysis and decision making aimed at reducing the MTTR. Included with this dissertation is feedback information that can be included in a maintenance job card feedback section to capture information about factors that can be improved to lower the MTTR as part of a continuous improvement process. Included also is a spare part development and management procedure that can be used by the maintenance function. Recommendations on training of maintenance personnel on the maintainability of equipment, the FMEA procedure and maintenance procedures are highlighted. Information that flowed from this approach will be valuable for continuous plant performance improvement and during the design, installation and operation stages of a blast furnace.
Thesis (M.Ing. (Development and Management Engineering))--North-West University, Potchefstroom Campus, 2012.
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Books on the topic "Reductive failure"

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Ozawa, Kazue. Liver surgery approached through the mitochondria: The Redox theory in evolution. Basel: Karger, 1992.

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McKitrick, Jennifer. The Failure of Conceptual Analysis. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198717805.003.0002.

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Dispositions are often regarded with suspicion. Consequently, some philosophers try to semantically reduce disposition ascriptions to sentences containing only non-dispositional vocabulary. Typically, reductionists attempt to analyze disposition ascriptions in terms of conditional statements. These conditional statements, like other modal claims, are often interpreted in terms of possible worlds semantics. However, conditional analyses are subject to a number of problems and counterexamples, including random coincidences, void satisfaction, masks, antidotes, mimics, altering, and finks. Some analyses fail to reduce disposition ascriptions to non-modal vocabulary. If reductive analysis of disposition ascriptions fails, then perhaps there can be metaphysical reduction of dispositions without semantic reduction. However, the reductionist still owes us an account of what makes disposition ascriptions true. But to posit a causal power for every unreduced dispositional predicate is an overreaction to the failure of conceptual analysis.
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Beattie, R. Mark, Anil Dhawan, and John W.L. Puntis. Intestinal failure. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569862.003.0013.

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Short-bowel syndrome 98Excessive diarrhoea 100Motility disorders 101Mucosal disorders 102The term intestinal failure (IF) refers to a functionally impaired gastrointestinal tract unable to maintain biochemical homeostasis and support normal growth. Short-bowel syndrome (SBS) is a common cause of IF and usually defined as a severe reduction in functional gut mass below the minimal amount necessary for digestion and absorption adequate to satisfy the nutrient and fluid requirements for growth. Other causes of IF include mucosal abnormalities giving rise to protracted diarrhoea, and neuromuscular disorders resulting in chronic idiopathic intestinal pseudo-obstruction syndrome (CIIPS). See ...
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Failure Mode and Effects Analysis in Health Care: Proactive Risk Reduction. Joint Commission Resources, 2005.

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Todinov, Michael T. Risk-Based Reliability Analysis and Generic Principles for Risk Reduction. Elsevier Science, 2006.

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Risk-Based Reliability Analysis and Generic Principles for Risk Reduction. Elsevier Science, 2006.

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Trestman, Robert L., and Ashbel T. Wall. Supply Reduction in Prison. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199374847.003.0015.

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Interdiction of addictive substances is a challenge in all settings. Prisons are no exception. Given the high prevalence of addictive disorders among prisoner populations the demand for illicit substances is very high. This chapter reviews the ways in which correctional staff have approached this concern, including a substantial focus on preventing illicit substances from entering the facility in the first place. This effort requires a broad array of interventions, including monitoring phone calls and mail; structuring and overseeing the visitation process; using trained canines; and employing intrusive searches any time a prisoner leaves the facility and returns. These efforts interface with an ongoing process to monitor prison activities for drugs that get past screening efforts. Random drug testing, canine tours of the facility, and an intricate system of informants, are each an element of effective monitoring activities. This chapter reviews the effectiveness and cost-effectiveness of such interventions, and considers the consequences of failure. Given that such consequences may include staff corruption and the development or growth of a prison drug economy, effective interdiction is a priority in every well-run facility.
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Ozawa, Kazue. Liver Surgery Approached Through the Mitochondria: The Redox Theory in Evolution. S Karger Pub, 1993.

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Keshav, Satish, and Alexandra Kent. Starvation and malnutrition. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0332.

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Starvation is a state of severe malnutrition due to a reduction in macro- and micronutrient intake. The basis underlying starvation is an imbalance between energy intake and energy expenditure. The commonest cause of starvation is lack of available food, usually due to environmental, social, and economic reasons, although other causes include anorexia nervosa; depression and other psychiatric disorders; coma and disturbance of consciousness; intestinal failure; and mechanical failure of digestion, including poor dentition and intestinal obstruction. Protein energy malnutrition is usually seen in developing countries. This chapter discusses starvation and malnutrition, focusing on their etiology, symptoms, demographics, natural history, complications, diagnosis, treatment, and prognosis.
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Seal, David Wyatt, Sarah Yancey, Manasa Reddy, and Stuart A. Kinner. Alcohol Use Among Incarcerated Individuals. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199374847.003.0004.

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This chapter examines alcohol use among individuals who experience incarceration. It reviews the epidemiology of alcohol use before prison, in prison, and after release from prison, and discusses the role of treatment and policy reform in reducing the health and social harms associated with alcohol use in this population. Finally, it summarizes key conclusions, including the lack of data from resource-poor settings where neither routine surveillance nor epidemiological research is common; the failure of much surveillance to distinguish between alcohol use and drug use; and the wide variability in the measurement of alcohol use, misuse, or dependence across studies. The chapter discusses the difficulties in assessing the effectiveness of alcohol use reduction programs in correctional systems, given that many programs prioritize drug use reduction as a primary goal, and that there are wide differences across correctional settings in the availability and quality of these services.
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Book chapters on the topic "Reductive failure"

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Batista, R. J. V. "Reduction ventriculoplasty." In Surgical Remodeling in Heart Failure, 97–104. Heidelberg: Steinkopff, 2000. http://dx.doi.org/10.1007/978-3-642-57705-5_9.

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Poole-Wilson, P. A. "Treatment of Heart Failure by “Afterload” Reduction: Vasodilator or Angiotensin Converting Enzyme Inhibitor?" In Heart Failure and Arrhythmias, 66–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75326-8_9.

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Lee, Richard, Mohammed A. Quader, Katherine J. Hoercher, and Patrick M. McCarthy. "Left Ventricular Volume Reduction Surgery for Idiopathic Dilated Cardiomyopathy." In Surgical Management of Congestive Heart Failure, 191–202. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-842-0:191.

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Zhang, Ke. "Joint Element and Strength Reduction Method." In Failure Mechanism and Stability Analysis of Rock Slope, 203–25. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-5743-9_10.

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Jones, Thomas B., and David H. Ackley. "Damage Reduction via White-Box Failure Shaping." In Search-Based Software Engineering, 213–28. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-99241-9_11.

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Singh, B. N., M. P. Schoenbaum, M. Antimisiaris, and C. Takanaka. "Prognostic Significance of Asymptomatic Ventricular Arrhythmias in Heart Failure: Potential for Mortality Reduction by Pharmacologic Control." In Heart Failure and Arrhythmias, 161–73. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75326-8_19.

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Zhang, Ke. "Strain-Softening Behavior and Strength Reduction Method." In Failure Mechanism and Stability Analysis of Rock Slope, 143–58. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-5743-9_7.

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Zhang, Ke. "Three-Dimensional Effect and Strength Reduction Method." In Failure Mechanism and Stability Analysis of Rock Slope, 159–83. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-5743-9_8.

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Stevenson, L. W. "Selection of Therapy for Patients with Advanced Heart Failure: Tailored Afterload Reduction or Cardiac Transplantation?" In Heart Failure Mechanisms and Management, 448–61. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-58231-8_48.

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Odey, Mike O. "Weaknesses and failures of poverty reduction policies and programs in Nigeria since 1960." In Poverty Reduction Strategies in Africa, 139–54. New York : Routledge, 2017. | Series: Global Africa ; v 3: Routledge, 2017. http://dx.doi.org/10.4324/9781315282978-9.

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Conference papers on the topic "Reductive failure"

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Cosham, Andrew, Jane Haswell, and Neil Jackson. "Reduction Factors for Estimating the Probability of Failure of Mechanical Damage Due to External Interference." In 2008 7th International Pipeline Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/ipc2008-64345.

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Quantified risk assessments (QRAs) are widely used in the UK to assess the significance of the risk posed by major accident hazard pipelines on the population and infrastructure in the vicinity of the pipeline. A QRA requires the calculation of the frequency of failures and the consequences of failures. One of the main causes of failures in onshore pipelines is mechanical damage due to external interference, such as a dent, a gouge, or a dent and gouge. In the published literature, two methods have been used to calculate the probability of failure due to external interference: • historical failure data and • limit state functions combined with historical data (i.e. structural reliability-based methods). Structural reliability-based methods are mathematically complicated, compared to using historical failure data, but have several advantages, e.g. extrapolation beyond the limited historical data, and the identification of trends that may not be apparent in the historical data. In view of this complexity, proposed supplements to the UK pipeline design codes IGE/TD/1 (natural gas) and PD 8010 (all substances) — on the application of QRAs to proposed developments in the vicinity of major accident hazard pipelines — include simple ‘reduction factors’ for use in ‘screening’ risk assessments. These ‘reduction factors’ are based on a comprehensive parametric study using a structural reliability-based model to calculate the probability of failure due to mechanical damage, defined as: gouges, and dents and gouges. The two ‘reduction factors’ are expressed in terms of the design factor and wall thickness of the pipeline. It is shown that, through appropriate normalisation, the effects of diameter, grade and toughness are secondary. Reasonably accurate, but conservative, estimates of the probability of failure can be obtained using these ‘reduction factors’. The proposed methodology is considerably simpler than a structural reliability-based analysis. The development and verification of these ‘reduction factors’ is described in this paper.
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Shahabuddin, Perwez, Victor F. Nicola, Philip Heidelberger, Ambuj Goyal, and Peter W. Glynn. "Variance reduction in mean time to failure simulations." In the 20th conference. New York, New York, USA: ACM Press, 1988. http://dx.doi.org/10.1145/318123.318239.

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Saee, Shamsudin Bin, Ng Hong Seng, and Tan Hong Mui. "Slurry Usage Reduction for Failure Analysis Sample Preparation." In 2007 5th Student Conference on Research and Development. IEEE, 2007. http://dx.doi.org/10.1109/scored.2007.4451387.

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Parekh, K. H., and R. Milburn. "Effectiveness of Emission Microscopy in the Failure Analysis of CMOS ASIC Devices." In ISTFA 1997. ASM International, 1997. http://dx.doi.org/10.31399/asm.cp.istfa1997p0299.

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Abstract In the last several years emission microscopy has become an essential tool for failure analysis, specifically for VLSI devices. This paper describes various die related failure mechanisms in CMOS ASIC devices which were detected by emission microscopy. The failure analysis results discussed in this paper are primarily of the devices which were analyzed over the period of the last three years, 1994 - 1996. These devices were from a broad spectrum of final test failures, qualification and reliability test failures, special evaluation failures, testing and assembly failures at customer sites, and end user field failures. In addition to the failure mechanism statistic scanning electron micrographic illustrations of some of the failure mechanisms and associated damage are presented in this paper. The data presented in this paper clearly show the effectiveness of photon emission microscopy. The value of emission microscopy really lies in quick detection of failure locations on the die which failed functionally or due to excessive static IOD, functional IOD, or input/output leakage currents. It has certainly impacted tum around time of the analysis as significant reduction in analysis time has been achieved. In some cases same day turn around was possible.
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Hubbard, Brad Lee, Shabib Kadri, Michael Crotinger, James Edward Griffith, and Eric Van Oort. "Nonproductive Time (NPT) Reduction Delivered Through Effective Failure Investigations." In IADC/SPE Drilling Conference and Exhibition. Society of Petroleum Engineers, 2010. http://dx.doi.org/10.2118/128425-ms.

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Michopoulos, John G., and Athanasios Iliopoulos. "Symbolic Algebra and Theorem Proving for Failure Criteria Reduction." In ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/detc2011-47737.

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The present paper reports on recent efforts of utilizing symbolic computing for identifying failure criteria cross reducibility from the perspective of theorem proving. Utilizing equational theorem proving algorithms and Gro¨bner Basis polynomial theorem provers implemented in Mathematica we have proven a number of interesting theorems related to the area of structural failure criteria for anisotropic and particularly orthotropic materials. The main contribution of this work is the demonstration of the tremendous utility of symbolic algebra for engineering applications as well as the demonstration of the idea that all failure criteria presented in the literature up to know can be proven under certain conditions to be special forms of general criteria relating to the strain energy density function associated with material continua. Two specific examples are presented and discussed along with a theorem proving the existence of a dual form of all stress space based criteria to equivalent one expressed in strain space.
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Jia, Qingxuan, Tong Li, Gang Chen, Hanxu Sun, and Jian Zhang. "Velocity jump reduction for manipulator with single joint failure." In 2014 International Conference on Multisensor Fusion and Information Integration for Intelligent Systems (MFI). IEEE, 2014. http://dx.doi.org/10.1109/mfi.2014.6997691.

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Gordon, Y. "Rising and Failure of Gas-Based Direct Reduction Processes." In AISTech 2021. AIST, 2021. http://dx.doi.org/10.33313/382/123-10513-043.

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Gordon, Y. "Rising and Failure of Gas-Based Direct Reduction Processes." In AISTech 2021. AIST, 2021. http://dx.doi.org/10.33313/382/023.

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Horbeek, J. H., W. Birch, M. J. McMahon, and K. Fearnley. "Successful Reduction of North Sea Drillstring Failures." In Offshore Europe. Society of Petroleum Engineers, 1995. http://dx.doi.org/10.2118/30348-ms.

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Reports on the topic "Reductive failure"

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Brown, Yolanda, Twonia Goyer, and Maragaret Harvey. Heart Failure 30-Day Readmission Frequency, Rates, and HF Classification. University of Tennessee Health Science Center, December 2020. http://dx.doi.org/10.21007/con.dnp.2020.0002.

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30 Day Hospital Readmission Rates, Frequencies, and Heart Failure Classification for Patients with Heart Failure Background Congestive heart failure (CHF) is the leading cause of mortality, morbidity, and disability worldwide among patients. Both the incidence and the prevalence of heart failure are age dependent and are relatively common in individuals 40 years of age and older. CHF is one of the leading causes of inpatient hospitalization readmission in the United States, with readmission rates remaining above the 20% goal within 30 days. The Center for Medicare and Medicaid Services imposes a 3% reimbursement penalty for excessive readmissions including those who are readmitted within 30 days from prior hospitalization for heart failure. Hospitals risk losing millions of dollars due to poor performance. A reduction in CHF readmission rates not only improves healthcare system expenditures, but also patients’ mortality, morbidity, and quality of life. Purpose The purpose of this DNP project is to determine the 30-day hospital readmission rates, frequencies, and heart failure classification for patients with heart failure. Specific aims include comparing computed annual re-admission rates with national average, determine the number of multiple 30-day re-admissions, provide descriptive data for demographic variables, and correlate age and heart failure classification with the number of multiple re-admissions. Methods A retrospective chart review was used to collect hospital admission and study data. The setting occurred in an urban hospital in Memphis, TN. The study was reviewed by the UTHSC Internal Review Board and deemed exempt. The electronic medical records were queried from July 1, 2019 through December 31, 2019 for heart failure ICD-10 codes beginning with the prefix 150 and a report was generated. Data was cleaned such that each patient admitted had only one heart failure ICD-10 code. The total number of heart failure admissions was computed and compared to national average. Using age ranges 40-80, the number of patients re-admitted withing 30 days was computed and descriptive and inferential statistics were computed using Microsoft Excel and R. Results A total of 3524 patients were admitted for heart failure within the six-month time frame. Of those, 297 were re-admitted within 30 days for heart failure exacerbation (8.39%). An annual estimate was computed (16.86%), well below the national average (21%). Of those re-admitted within 30 days, 50 were re-admitted on multiple occasions sequentially, ranging from 2-8 re-admissions. The median age was 60 and 60% male. Due to the skewed distribution (most re-admitted twice), nonparametric statistics were used for correlation. While graphic display of charts suggested a trend for most multiple re-admissions due to diastolic dysfunction and least number due to systolic heart failure, there was no statistically significant correlation between age and number or multiple re-admissions (Spearman rank, p = 0.6208) or number of multiple re-admissions and heart failure classification (Kruskal Wallis, p =0.2553).
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Rahmani, Mehran, and Manan Naik. Structural Identification and Damage Detection in Bridges using Wave Method and Uniform Shear Beam Models: A Feasibility Study. Mineta Transportation Institute, February 2021. http://dx.doi.org/10.31979/mti.2021.1934.

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This report presents a wave method to be used for the structural identification and damage detection of structural components in bridges, e.g., bridge piers. This method has proven to be promising when applied to real structures and large amplitude responses in buildings (e.g., mid-rise and high-rise buildings). This study is the first application of the method to damaged bridge structures. The bridge identification was performed using wave propagation in a simple uniform shear beam model. The method identifies a wave velocity for the structure by fitting an equivalent uniform shear beam model to the impulse response functions of the recorded earthquake response. The structural damage is detected by measuring changes in the identified velocities from one damaging event to another. The method uses the acceleration response recorded in the structure to detect damage. In this study, the acceleration response from a shake-table four-span bridge tested to failure was used. Pairs of sensors were identified to represent a specific wave passage in the bridge. Wave velocities were identified for several sensor pairs and various shaking intensities are reported; further, actual observed damage in the bridge was compared with the detected reductions in the identified velocities. The results show that the identified shear wave velocities presented a decreasing trend as the shaking intensity was increased, and the average percentage reduction in the velocities was consistent with the overall observed damage in the bridge. However, there was no clear correlation between a specific wave passage and the observed reduction in the velocities. This indicates that the uniform shear beam model was too simple to localize the damage in the bridge. Instead, it provides a proxy for the overall extent of change in the response due to damage.
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