Dissertations / Theses on the topic 'Recovery events'
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Switzer, Jennifer Margaret. "Recovery times and adverse events between propofol and midazolam during colonoscopy." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45308.
Full textHumm, Jennifer Leigh. "Behavior-dependent neural events and adult neurogenesis : contributions to recovery of motor function after cortical injury /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.
Full textLisk, Godfrey Olufemie. "Evaluating the molecular events that underlie functional recovery of botulinum poisoned neurones in vitro and in vivo." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268721.
Full textField, Stuart. "Recovery of coral reef communities following disturbance associated with ship-grounding events in the Gulf of Aqaba, Egypt." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442330.
Full textChan, Wing-han Esther. "Road to recovery : adjustment and services needed for those suffering from spinal cord injury /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20131835.
Full textEdwards, Douglas Grant. "Strategic Managerial Responses to Critical Service Events in Restaurants." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2067.
Full textGarcía, James J. "Racial/ethnic Differences in Hospital Utilization for Cardiovascular-related Events: Evidence of a Survival and Recovery Advantage for Latinos?" Thesis, University of North Texas, 2014. https://digital.library.unt.edu/ark:/67531/metadc500102/.
Full textNyman, Nick, and Smura Michel Postigo. "Examining how unforeseen events affect accuracy and recovery of a non-linear autoregressive neural network in stock market prognoses." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-186435.
Full textDenna studie undersöker hur ett icke-linjärt autoregressivt neuronnät för aktiemarknadsprognoser påverkas av oväntade händelser. Studien ämnar finna återhämtningsperioden för nätverket efter en händelse, och ta reda på om den initiala påverkan av händelsen påverkar återhämtningen. Tester av endagsprognosers avvikelse från det verkliga värdet genomförs på fem verkliga aktier och fyra skapade dataset som exkluderar den omgivande variationen från aktiemarknaden. Dessa simulerade set isolerar därmed specifika typer av händelser. Studien drar slutsatsen att storleken av händelsen har försumbar betydelse på återhämtningstiden och att plötsliga händelser tillåter återhämtning på några dagar oavsett händelsens ursprungliga storlek eller förändring av prisutvecklingshastighet. Däremot förlänger utdragna händelser återhämtningstiden. Likaså påverkar efterskalv eller kvarvarande instabilitet i prisutvecklingen tillförlitlighet och återhämtningstid avsevärt.
Paul, Nicole Christine. "Variable Recovery of the Massive Coral, Porites Lobata, in Response to El Nino-Southern Oscillation Events at Devil's Crown, Galapagos, Ecuador." NSUWorks, 2012. http://nsuworks.nova.edu/occ_stuetd/93.
Full textChan, Wing-han Esther, and 陳詠嫻. "Road to recovery: adjustment and services needed for those suffering from spinal cord injury." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31250440.
Full textPellecchia, Antonella. "Experimental analysis of the effects of extreme events of mechanical disturbance on rocky shore algal and invertebrate assemblages in the Bagnoli-Coroglio post-industrial area and in reference sites in the Gulf of Naples." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/17977/.
Full textDahl, Catarina Magalhães 1978. "Experiência, narrativa e intersubjetividade : o processo de restabelecimento ("recovery") na perspectiva de pessoas com o diagnóstico de esquizofrenia em tratamento nos centros de atenção psicossocial." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309193.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-20T22:29:56Z (GMT). No. of bitstreams: 1 Dahl_CatarinaMagalhaes_M.pdf: 3047572 bytes, checksum: 43a67553dc0085c1ae55d0b2e47fd4e6 (MD5) Previous issue date: 2012
Resumo: O processo de restabelecimento (recovery), referido ao tema da experiência do adoecimento, na perspectiva de pessoas com problemas mentais graves, vem sendo cada vez mais investigado no panorama mundial. Desde a década de 1960, diversos estudos colocam em xeque o legado kraepeliniano acerca da esquizofrenia como um transtorno cujo prognóstico leva à progressiva deterioração e cronicidade. Tais estudos revelam a existência de um amplo e heterogêneo espectro de desfechos relativos ao processo saúde-doença vivenciado pelas pessoas com o diagnóstico de esquizofrenia. No Brasil, os Centros de Atenção Psicossocial (CAPS) surgem no âmbito dos movimentos de Reforma Psiquiátrica e Sanitária, como equipamentos estratégicos, que têm como missão promover o acesso à saúde, o acolhimento, o cuidado integral e a reabilitação psicossocial das pessoas com problemas mentais graves, através da valorização das experiências e narrativas dos usuários destes serviços. Alguns autores, entretanto, atentam ao fato de que os CAPS ainda encontram desafios e obstáculos para superação do cuidado médico-centrado e hospitalocêntrico. Esta dissertação de mestrado está vinculada a um projeto de pesquisa mais amplo, realizado através da parceria entre a UFRJ, UNICAMP, UFF e a UFBA, com o apoio do CNPq. Trata-se de um estudo qualitativo multicêntrico no qual se buscou analisar, a partir do quadro de referência da Fenomenologia interpretativa, as narrativas sobre a experiência do processo de restabelecimento (recovery), na perspectiva de pessoas que receberam o diagnóstico de esquizofrenia em tratamento nos CAPS de Campinas, Rio de Janeiro e Salvador. As estratégias metodológicas utilizadas para produção das informações foram: observação participante, entrevistas diagnósticas semi-estruturadas e grupos focais, que foram áudio-gravados e posteriormente transcritos, codificados e analisados. Dentre os 18 usuários participantes, 12 eram do gênero masculino, 10 eram solteiros, 7 eram brancos e 5 eram afro-descendentes (3 em Salvador e 2 no Rio). O nível de escolaridade dos participantes foi o seguinte: 8 usuários com ensino médio completo, 6 usuários com ensino médio incompleto e 4 com ensino fundamental incompleto. A média de idade dos usuários foi de aproximadamente 44 anos, com idade mínima de 30 anos e máxima de 64 anos. A partir do material analisado, identificamos as seguintes categorias temáticas: restabelecimento da experiência/consciência de si; efeitos do adoecimento; diagnóstico e efeitos do diagnóstico; experiência e efeitos da medicação; estratégias de lida e de existência; possibilidades e expectativas relacionadas ao futuro; causas/contingências relacionadas ao processo de restabelecimento; ideia de cura/melhora; contexto de tratamento nos CAPS; contexto dinâmico de vida/relações familiares e interpessoais e continuidade/descontinuidade da experiência, entre outras categorias. Nós também encontramos diferentes modos ou tipos de narrativas, como: causas/contingências, protótipos, descrição da experiência, narrativas éticomorais e narrativas corporificadas. Na perspectiva dos usuários, o restabelecimento (recovery) caracteriza-se como um processo complexo, não-linear, que envolve diferentes dimensões da vida. Apesar de vislumbrarem a possibilidade de melhora, para os usuários a perspectiva de cura e retorno a um estado anterior ao adoecimento parece remota, co-existindo, assim, perspectivas mais e/ou menos auspiciosas em relação ao processo de restabelecimento
Abstract: The recovery process, in the perspective of persons who received the diagnosis of schizophrenia, it has been increasingly studied worldwide. Since the 1960's, different studies has been questioned the kraepelin's legacy in which schizophrenia is seen as necessarily degenerating and chronic disorder. Such studies reveal the existence of a wide and heterogeneous spectrum of outcomes related to the disorder. In Brazil, the Psychosocial Care Centers (CAPS) arise in the context of Psychiatric and Sanitary Reforms, as strategic services which objective is to promote the access,receptiveness, mental, comprehensive mental health care and social rehabilitation for persons with serious mental disorders However, some authors alert to the fact that the CAPS still find challenging obstacles to overcome the hospitalocentric care model This masters's dissertation is bounded to a wider multisite research project, carried out through a partnership between UFRJ, UNICAMP, UFF and UFBA and was funded by CNPq. It is a qualitative inquiry in wherein we analyzed, informed by the reference frame of Phenomenology and Hermeneutics, the narratives on the process of recovery, in the perspective of people with severe mental disorder, in treatment at the CAPS in Campinas, Rio de Janeiro and Salvador. The methodological strategies for data collection was participant observation, diagnosis interviews and focus groups, which were recorded, transcribed, codified and analyzed Among the 18 participants, 12 were men, 10 were single, 7 caucasian and 5 afrodescendents (3 in Salvador and 2 in Rio) and 10 users's had less than 8 years of study. The age mean was 44 years, with minimum age with 30 years and maximum 64 a. We identified the following categories from data analysis: self experience/selfawareness; illness process effects; diagnosis and diagnosis effects; existence and coping strategies;possibilities related to the future; recovery process causes and contingences; idea of cure/mental health increasing; CAPS and treatment context; life dynamic context and family and interpersonal relations and continuity/discontinuity of experience. We found as well different narrative modes or types, such as: cause and contingence; prototypes; description of experience; ethical and moral narratives and embodied narratives. In the perspective of users, the recovery process is characterized as a non-linear and complex process, which involves different dimensions of daily life. Despite of glimping the possibility of mental health increasing, the cure and the return to pré-morbid state seems to be a remote possibility for the users which indicates the co-existence of more and/or less auspicious perspectives related to the recovery process
Mestrado
Política, Planejamento e Gestão em Saúde
Mestre em Saude Coletiva
Love, Beverly. "The cycle of relapse and recovery of substance misusing offenders on a community based rehabilitation programme : the impact of childhoods, family, relationships, significant life events and psychological wellbeing : an interpretative phenomenological analysis and approach." Thesis, University of Surrey, 2018. http://epubs.surrey.ac.uk/845638/.
Full textRumball, Freya. "Studying individual differences and emotion regulation effects on PTSD-like responding and recovery : a psychophysiological VR-trauma paradigm." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/14171.
Full textMartin, Zebulon. "Effects of Precipitation on the Acid Mine Drainage Impacted Hewett Fork Watershed." Ohio University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1493754192668286.
Full textRabbani, Fábio Faizi Rahnemay 1978. "Implementation of an airline recovery model in an event-based simulation." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/17786.
Full textIncludes bibliographical references (leaves 95-97).
Airlines maximize the use of their resources by minimizing the time between consecutive flight legs in their aircraft and crew schedules. As a result, bad weather or unscheduled aircraft maintenance events can have a significant impact on an airline's operations. The consequences of these disruptions are major costs to airlines, passengers and, ultimately, to the economy itself. In this thesis, the steps taken to implement an airline schedule recovery model in a realistic simulation of the U.S. airspace system are presented. The MIT Extensible Network Simulation (MEANS), an event based queueing model of the U.S. National Airspace System, can be used for tactical decision making, long term decision making and post priori event analysis. Thus, the addition of a recovery model is critical to obtain accurate simulation results. The airline recovery model consists of an optimized aircraft re-scheduling model, a crew re-assigning model and a heuristic passenger itinerary search model. The model was used to simulate airline recovery procedures over the course of a day of operations for different scenarios.
by Fábio Faizi Rahnemay Rabbani.
S.M.
Yates, Bernice Helen. "Illness demands and social support during recovery from a cardiac illness event /." Thesis, Connect to this title online; UW restricted, 1989. http://hdl.handle.net/1773/7268.
Full textAbraham, William Todd. "Dispositional optimism and pessimism stability, change, and adaptive recovery following life event experiences /." [Ames, Iowa : Iowa State University], 2007.
Find full textPicoco, Claudia. "Integrated Framework for Representing Recoveries Using the Dynamic Event Tree Approach." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu155550242815033.
Full textSambo, Mogamat Fadeel. "An investigation into Business Continuity Plan (BCP) failure during a disaster event." University of the Western Cape, 2012. http://hdl.handle.net/11394/4575.
Full textThis thesis examines what a Business Continuity Plan (BCP) should comprise off, as well as the difference between a BCP and a Disaster Recovery Plan (DRP) and the key elements of an effective BCP as well as the different types of disasters. It also investigates why companies that have BCP in place and conducts testing of their plan on a regular basis, either quarterly or bi-annually, still experience prolonged downtime during a disaster resulting in Service Level Agreements (SLA) not being met or major financial loses. It also inspects acceptable processes within a BCP to determine whether there are ways of improving these processes to prevent companies from experiencing prolonged downtime. The objective of this research is to determine and understand: Why organisations within the Western Cape experience prolonged downtimes during a disaster event. The potential deficiencies in a BCP and how they can be amended. A case study of four companies based in the Western Cape was conducted. These companies were chosen because each of them has a BCP in place and each have experienced prolonged downtime during a disaster. Qualitative interviews with the aid of an open-ended questionnaire were used to interview the BCP or Risk Manager of each company. The data was analysed to determine what the causes of their prolonged downtime were during a disaster. In the analysis and findings process each company is presented as a separate case study. The intension with this research study is to add an additional concept to the Common BCP Process that was identified within this study and that formed the basis for the Conceptual Framework, thereby reducing the downtime during a disaster for the companies that formed part of the research.
Colley, Rich. "Hearts and minds : how do people experience and psychologically recover from traumatic cardiac treatment-related events?" Thesis, Lancaster University, 2014. http://eprints.lancs.ac.uk/70736/.
Full textBuglass, Salome. "A study on the recovery of Tobago's coral reefs following the 2010 mass bleaching event." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/51752.
Full textArts, Faculty of
Geography, Department of
Graduate
Nordick, Wendy Gale. "Insight into insight : a study on understanding schizophrenia." Thesis, University of Canterbury. School of Social Work and Human Services, 2009. http://hdl.handle.net/10092/2531.
Full textHollis, Melanie. "Formulating Disaster Recovery Plans for New Zealand: using a case study of the 1931 Napier Earthquake." Thesis, University of Canterbury. Geological Sciences, 2007. http://hdl.handle.net/10092/1456.
Full textKalibjian, Jeffrey R. "Accountable Security Architectures for Protecting Telemetry Data." International Foundation for Telemetering, 2001. http://hdl.handle.net/10150/606436.
Full textToday there are many security solutions available which can facilitate both protection and sharing of telemetry data. While the technologies behind these solutions are maturing [1] [2] [3], most products lack a consistent and coherent paradigm for enforcing who is able to access the secured data, what is done with it, and insuring it can be recovered if the person who secured it is disabled.
Ozlu, Ahmet Oguzhan. "Optimization approaches for designing baseball scout networks under uncertainty." Diss., Georgia Institute of Technology, 2016. http://hdl.handle.net/1853/54983.
Full textWahl, Darin. "Exploring pathways to transformations in post-disaster-event communities: A case study on the Mad River Valley, Vermont, USA." Thesis, Stockholms universitet, Stockholm Resilience Centre, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-110153.
Full textSnydeman, Colleen Kirwan. "Evaluation of the effect of the Peer Review Impacts Safety and Medical-errors (PRISM) Program on critical care nurses' attitudes of safety culture and awareness of recovery of medical errors:." Thesis, Boston College, 2017. http://hdl.handle.net/2345/bc-ir:107293.
Full textProblem: Nurses act as safety nets, protecting patients from harm through the identification, interruption and recovery of medical errors and adverse events but we need to know more about ways to learn from safety events. This study aimed to address a gap in our understanding of how the PRISM Program affects nurses’ attitudes of safety culture, awareness of the recovery of medical errors, and practice as they relate to patient safety and error prevention. Participants: Critical care nurses in a large academic hospital from intervention (n=95) and control (n=90) units were surveyed pre and post-implementation of the PRISM Program. Intervention unit nurse response rates were 46% pre-survey and 41% post-survey. Control unit nurses' response rates were 38% for pre-survey and 31% for post-survey responses. A total of 42 (44%) intervention unit nurses participated in the PRISM Program. Methods: A pre/post-test design with an intervention and control unit was used to evaluate the effects of the PRISM Program on nurses’ responses on the Safety Attitude Questionnaire (SAQ) and the Recovery of Medical Error Inventory (RMEI) over a three month period. Nurses responded to questions about the impact on their practice. Findings: Analysis demonstrated a significant decrease in the SAQ working conditions post-survey subscale scores and significant findings in the main effects, decreased SAQ subscales: teamwork, job satisfaction, safety climate and perceptions of hospital management. The RMEI did not produce any significant findings. Comments provided insight into some nurses’ participation in the program and the impact on their practice. Implications: A significant decrease in post-survey scores indicate that informed nurses had a more critical view of safety culture and the environment they work in. Nurses expressed a desire to further use surveillance and additional manual checks that placed increased accountability and responsibility for their role in using strategies to keep patient safe and prevent errors and patient harm
Thesis (PhD) — Boston College, 2017
Submitted to: Boston College. Connell School of Nursing
Discipline: Nursing
Thureborn, Rasmus, and Victor Klaxman. "Terrorism - ett hot mot ekonomin? : En eventstudie om hur terroristattacker påverkar den svenska aktiemarknaden." Thesis, Södertörns högskola, Institutionen för samhällsvetenskaper, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-27915.
Full textElangovan, Saravanan, Jerry L. Cranford, Letitia Walker, and Andrew Stuart. "A Comparison of the Mismatch Negativity and a Differential Waveform Response." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etsu-works/1556.
Full textFerreira, Ronaldo Rodrigues. "The transactional HW/SW stack for fault tolerant embedded computing." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/114607.
Full textFault tolerance implementation in embedded systems is challenging because the physical constraints of area occupation, power dissipation, and energy consumption of these systems. The need for optimizing these three physical constraints while doing computation within the available performance goals and real-time deadlines creates a conundrum that is hard to solve. Classical fault tolerance solutions such as triple and dual modular redundancy are not feasible due to their high power overhead or lack of efficient and deterministic error recovery. Existing techniques, although some of them reduce the power and area overhead, incur heavy perfor- mance penalties and most of the time do not assume a feasible fault model. This dissertation introduces the Transactional HW/SW Stack, or simply Stack, to effi- ciently manage the area, power, fault coverage, and performance conundrum. The Stack introduces a new compilation strategy that assembles programs into Transac- tional Basic Blocks, together with a novel microprocessor, the TransactiOnal Basic Block Architecture (ToBBA), which provides fine-grained error detection and deter- ministic error rollback and elimination using the Transactional Basic Blocks (TBBs) both as a container for errors and as a small unit of data checkpointing. Two so- lutions to sustain the TBB semantics in hardware are introduced: software- and hardware-based. Stack’s area, power, performance, and coverage were evaluated using ToBBA’s hardware implementation model. The Stack attains an error correc- tion coverage of 99.35% with 2.05 power overhead within an area overhead of 2.65. The Stack also presents a performance overhead of 1.33 or 1.54, depending on the hardware model adopted to support the TBB.
Orire, Endurance. "The techno-economics of bitumen recovery from oil and tar sands as a complement to oil exploration in Nigeria / E. Orire." Thesis, North-West University, 2009. http://hdl.handle.net/10394/5704.
Full textThesis (M.Ing. (Development and Management))--North-West University, Potchefstroom Campus, 2010.
Becker, Andrew John. "Impact of precipitating events on pediatric chronic pain recovery." Thesis, 2016. https://hdl.handle.net/2144/16808.
Full textCohen, Lawrence J. 1958. "Coping with traumatic events : a theoretical model and a study of recovery from rape." Phd diss., 1985. http://hdl.handle.net/10161/13561.
Full textThis thesis was digitized as part of a project begun in 2014 to increase the number of Duke psychology theses available online. The digitization project was spearheaded by Ciara Healy.
Saboori, Anooshiravan. "Fault recovery using discrete event models." Thesis, 2005. http://spectrum.library.concordia.ca/8480/1/MR10250.pdf.
Full textKrejčí, Zuzana. "Připravenost absolventů vzdělávacích kurzů na hlavního vedoucího zotavovacích akcí pro děti a mládež k výkonu funkce." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-446354.
Full textHarrison, R. (Nee Sirriyeh R. )., R. Lawton, J. Perlo, P. Gardner, Gerry R. Armitage, and J. Shapiro. "Emotion and coping in the aftermath of medical error: A cross country exploration." 2013. http://hdl.handle.net/10454/5552.
Full textBritish Psychological Society Travel Grant
Serrano, Ana Rita Neves. "Importância e efeitos de incidentes críticos na satisfação e lealdade do cliente." Master's thesis, 2009. http://hdl.handle.net/10362/2632.
Full textÉ importante perceber quais os incidentes que levam os clientes a abandonarem uma empresa, é igualmente importante perceber como uma empresa os pode evitar. Existem vários tipos de incidentes consoante o tipo de serviço e o contexto em que eles ocorrem, mas todos provocam alterações no comportamento dos clientes que podem ser benéficos ou não para a empresa. Assim, para garantir a permanência dos clientes como tal, as empresas querem clientes leais e satisfeitos que passem a palavra (positiva), e para tal têm de ter conhecimento desses mesmos clientes e prever de certa forma as razões de um possível abandono. Os incidentes críticos podem ser definidos consoante a situação a que se referem, no entanto acabam por se enquadrar em dois grandes grupos – Positivos ou Negativos. No fundo, são acontecimentos, momentos, experiências que ocorrem durante a relação cliente-empresa podendo alterar o comportamento do consumidor. São os incidentes críticos negativos que têm um maior efeito na confiança, satisfação e lealdade do cliente tendo um maior impacto na satisfação. Enquanto que os incidentes críticos positivos fomentam a satisfação do cliente, lealdade do cliente e intenções de compra, os incidentes críticos negativos afectam o comportamento do consumidor e levam a reclamações do consumidor, redução na boa vontade em ser cliente da firma de retalho, e em espalhar um comportamento de Word-of-mouth negativo. A intensidade e severidade de um evento, influenciam também o comportamento dos consumidores e quanto maior a intensidade e severidade desse evento, maiores serão os efeitos nocivos na satisfação e lealdade dos clientes.(...)
Moradi, Abdolmajid. "Hierarchical modular fault recovery in discrete-event systems." Thesis, 2006. http://spectrum.library.concordia.ca/8941/1/MR14275.pdf.
Full textMoosaei, Mohammad. "Fault recovery in control systems : a discrete event system approach." Thesis, 2003. http://spectrum.library.concordia.ca/2276/1/MQ83873.pdf.
Full textWang, Chenhuan. "Fault recovery in discrete-event systems using observer-based supervisors." Thesis, 2005. http://spectrum.library.concordia.ca/8544/1/MR10253.pdf.
Full textKoraginjala, Ganesh. "Fault recovery in discrete-event systems with intermittent and permanent failures." Thesis, 2009. http://spectrum.library.concordia.ca/976428/1/MR63170.pdf.
Full text"The inhibitory effect of genistein on the recovery from apoptotic event in cancer cells." 2012. http://library.cuhk.edu.hk/record=b5549212.
Full text在這項研究中,我們證明了在質膜不對稱的散失和半胱天冬酶(caspase)啟動後,HeLa細胞的凋亡的啟動可逆轉。我們發現,除了被廣泛研究的抗增殖作用外,金雀異黃素(genistein)可抑制細胞凋亡的復蘇。即時定量PCR發現抗凋亡基因MDM2和XIAP在凋亡逆轉過程中表達水準上調,金雀異黃素可抑制其表達水準的上調。金雀異黃素,MDM2蛋白抑制劑和XIAP抑制劑的利用,造成復原細胞內持續的半胱天冬酶活性和增強的細胞死亡效果。然而,半胱天冬酶抑制劑並不能挽救金雀異黃素的抑制作用。流式細胞儀的研究表明,金雀異黃素可以導致凋亡逆轉細胞持久磷脂醯絲氨酸(PS)外化和逆轉細胞的細胞壞死。抑制半胱天冬酶活性將金雀異黃素的主要作用轉移到壞死效果。這些結果揭示了金雀異黃素抑制細胞凋亡逆轉的兩個可能的機制。
金雀異黃素能維持現有的細胞凋亡信號從而增強細胞凋亡。它也可以破壞凋亡恢復過程,導致繼發性壞死。金雀異黃素對於細胞凋亡逆轉的抑制可與常規化療相結合,以提高治療結果.
It is well documented that chemotherapeutical agents could induce apoptosis of cancer cells, which is recognized as a major treatment effect of chemotherapy. Accumulating evidence indicates that chemopreventive agents like soybean isoflavone genistein could potentiate the antitumor effect of chemotherapeutic drugs both in vivo and in vitro. The mechanistic basis of this augmentation effect by genistein remains to be fully elucidated.
In this study, we demonstrated while low-concentration ethanol stressed cancer cells could recover, the presence of genistein promoted the cell death of stressed cancer cells that displayed apoptotic features. In HeLa cells, quantitative real-time PCR revealed the up-regulation of anti-apoptotic genes MDM2 and XIAP during the recovery process, and genistein suppressed their expression. The application of genistein, MDM2 inhibitor and XIAP inhibitor to the recovering HeLa cells caused persistent caspase activity and enhanced cell death. However, the death-promoting effect of genistein was not rescued by caspase inhibitor. Flow cytometry study indicated that genistein treatment could lead to persistent phosphatidylserine (PS) externalization and necrotic events in the recovering HeLa cells. Caspase activity inhibition shifted the major effect of genistein to secondary necrosis.
These results suggested two possible mechanisms through which genistein promoted cell death in stressed HeLa cells. Genistein could maintain the existing apoptotic signal to enhance apoptotic cell death. It could also disrupt the recovering process in caspase-independent manner, which lead to secondary necrosis. These effects may account for the enhanced antitumor effect of chemotherapeutic drugs when they were combined with genistein.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Xie, Xin.
Thesis (M.Phil.)--Chinese University of Hong Kong, 2012.
Includes bibliographical references (leaves 79-90).
Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Abstracts in also in Chinese.
Cover Page
Statement --- p.i
Thesis Committee members --- p.ii
Acknowledgements --- p.iii
Abstract --- p.iv
Table of contents --- p.vi
List of abbreviations --- p.ix
List of figures and tables --- p.xi
Chapter Chapter 1 --- General Introduction --- p.1
Chapter 1.1 --- Introduction to general cancer biology --- p.1
Chapter 1.1.1 --- Overview of cancer --- p.1
Chapter 1.1.1.1 --- Classification of cancer --- p.1
Chapter 1.1.1.2 --- Risk factors of carcinogenesis --- p.2
Chapter 1.1.1.3 --- Cancer prevention and therapies --- p.4
Chapter 1.1.2 --- Models of cancer development --- p.6
Chapter 1.1.2.1 --- Multistage model of carcinogenesis --- p.6
Chapter 1.1.2.2 --- Colorectal cancer as an example of multistep / multigene carcinogenesis --- p.7
Chapter 1.1.2.3 --- Driving force for cancer development --- p.9
Chapter 1.1.3 --- Properties of cancer cells --- p.11
Chapter 1.2 --- Apoptosis and its roles in cancer development and treatment --- p.14
Chapter 1.2.1 --- Overview of apoptosis --- p.14
Chapter 1.2.2 --- Molecular mechanism of apoptosis --- p.15
Chapter 1.2.3 --- Positive and negative regulation of apoptosis --- p.18
Chapter 1.2.4 --- Apoptotic defects in cancer development --- p.20
Chapter 1.2.5 --- Apoptosis in cancer treatment --- p.23
Chapter 1.3 --- The reversibility of apoptotic events --- p.25
Chapter 1.4 --- Genistein and its relevance to cancer therapy --- p.27
Chapter 1.5 --- Objectives of the study --- p.29
Chapter Chapter 2 --- Materials and Methods --- p.30
Chapter 2.1 --- Materials --- p.30
Chapter 2.1.1 --- Cancer cell lines --- p.30
Chapter 2.1.2 --- Cell culture media and additives --- p.30
Chapter 2.1.3 --- Biochemical kits --- p.30
Chapter 2.1.4 --- Chemicals and reagents --- p.30
Chapter 2.1.5 --- Antibodies --- p.31
Chapter 2.1.6 --- Primers used for quantitative real-time PCR --- p.32
Chapter 2.1.7 --- Buffers and solutions --- p.32
Chapter 2.2 --- Methods and procedures --- p.33
Chapter 2.2.1 --- Cell culture establishment and cryopreservation --- p.33
Chapter 2.2.2 --- Living cell staining and imaging --- p.34
Chapter 2.2.3 --- MTT cell viability assay --- p.34
Chapter 2.2.4 --- BrdU cell proliferation assay --- p.35
Chapter 2.2.5 --- LDH cytotoxicity assay --- p.35
Chapter 2.2.6 --- Quantitative real-time PCR --- p.36
Chapter 2.2.7 --- Western blotting --- p.37
Chapter 2.2.8 --- Annexin V/ Propidium Iodide Assay --- p.38
Chapter 2.2.9 --- Trypan Blue Dye Exclusion Assay --- p.39
Chapter 2.2.10 --- Cleaved-Caspase 3 Immunostaining --- p.39
Chapter 2.2.11 --- Statistical Analysis --- p.39
Chapter Chapter 3 --- Results --- p.40
Chapter 3.1 --- Low concentration ethanol stressed cancer cells displayed apoptotic features and the stressed cell could recover after stress removal --- p.40
Chapter 3.1.1 --- Morphological changes and apoptotic marker activation in low concentration ethanol stress --- p.40
Chapter 3.1.2 --- In situ study of morphological changes and caspase 3 activation in HeLa --- p.44
Chapter 3.2 --- Genistein promoted the cell death of stressed cancer cells at non-cytotoxic concentration towards unstressed cells --- p.46
Chapter 3.2.1 --- Dose-dependent response of genistein on stressed and unstressed cells --- p.46
Chapter 3.2.2 --- In HeLa cells, genistein suppressed the recovery from stress treatment at non-cytotoxic concentration --- p.48
Chapter 3.2.3 --- Genistein promoted both apoptosis and necrosis in stressed cells. . --- p.49
Chapter 3.3 --- Genes involved in the recovery from stress treatment were influenced by genistein --- p.53
Chapter 3.3.1 --- Stressed HeLa cells were more sensitive to the inhibition of de novo synthesis --- p.53
Chapter 3.3.2 --- Expression profiles of genes involved in recovery and the influence of genistein --- p.55
Chapter 3.4 --- Like genistein, MDM2 and XIAP inhibitor potentiated the cell death and caused persistent caspase-3 activity in stressed cells --- p.58
Chapter 3.4.1. --- Stressed HeLa cells were much more sensitive to the inhibition of XIAP and MDM2 --- p.58
Chapter 3.4.2 --- The presence of inhibitor at non-cytotoxic concentration to unstressed cells suppressed the recovery of the stressed cells --- p.60
Chapter 3.4.3 --- Genistein, MDM2 inhibitor and XIAP inhibitor caused persistent apoptotic signals in recovering cells. --- p.61
Chapter 3.5 --- The death-promoting effect by genistein could be caspase-independent --- p.64
Chapter 3.6 --- Caspase activity abrogation shifted genistein’s action profile --- p.66
Chapter Chapter 4 --- Discussion and prospect --- p.70
Chapter 4.1 --- The apoptotic features were induced by low concentration ethanol stress --- p.70
Chapter 4.2 --- The apoptotic features caused by ethanol stress were reversible --- p.71
Chapter 4.3 --- Genistein showed death-promoting effects on the recovering cells --- p.72
Chapter 4.4 --- The genes (XIAP and MDM2) that were involved in the recovery process may function to terminate apoptotic signal --- p.73
Chapter 4.5 --- Genistein suppressed the upregulation of anti-apoptotic genes and promoted the expression of pro-apoptotic genes --- p.74
Chapter 4.6 --- The XIAP and MDM2 activity were essential for the recovery from stress --- p.75
Chapter 4.7 --- Caspase inhibition increased the secondary necrosis in recovering cells with genistein treatment --- p.76
Chapter 4.8 --- Hypothetic mechanism of genistein’s inhibitory effect on the recovery of stressed cells --- p.77
Chapter 4.9 --- Summary and prospects --- p.78
Reference list --- p.79
Deale, Maria. "Recovery dynamics of zooplankton following a mouth-breaching event in the temporarily-open Mdloti Estuary." Thesis, 2010. http://hdl.handle.net/10413/8419.
Full textThesis (M.Sc.)-University of KwaZulu-Natal, Westville, 2010.
Clunas, Nathan Psychiatry Faculty of Medicine UNSW. "An auditory event-related potential study of recovery cycle effects in schizophrenia and bipolar disorder." 2007. http://handle.unsw.edu.au/1959.4/40487.
Full textPorter, Stephen. "An architectual mind : the nature of real, created, and fabricated memories for emotional childhood events." Thesis, 1998. http://hdl.handle.net/2429/9568.
Full textHuang, Ta-Shun, and 黃大順. "The Moderating Effect of Consumer Experience on How Service Recovery Influences the Evaluation of Corporate and Brand Images: A Case of the Apple's iPhone Upgrade Event." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/t2bpdh.
Full text龍華科技大學
企業管理系碩士班
107
The popularity of smart phones has made more competition between operators. Therefore, consumers increasingly demanded the quality of products and services. Therefore, when products fail, remediation becomes a great concern. In 2017, the slowdown of the iPhone's software upgrades has seriously affected its sales and brand image, and it even led to serious consequences of consumer class actions. However, in addition to the general negative evaluation, there are other consumers who have different opinions, which in turn leads consumers to have different attitudes towards the Apple brand. This study argues that consumers have different perspectives because the consumer experience plays an important role in the past. That is, a positive consumer experience can often repel the mistakes made by the industry’s negligence, while a negative consumer experience may worsen the existing attitude towards the brand. In this study, we used iPhone consumers as the sample pool to control its characteristics, trying to understand the consumer's perception of the industry remediation, the subsequent corporate image and brand image under the influence of the aforementioned perception, and whether there is a difference in the evaluation. In this study, the questionnaire survey method was used to collect data, and a questionnaire was sent to a science and technology university in Taoyuan to answer the questions. The total number of the questionnaire was 163. The following findings were obtained from the data analysis results: 1.Service Remediation Awareness has a positive and significant impact on the corporate image and brand image. 2.Corporate image and brand image have a positive and significant impact on consumers’ loyalty. 3.The consumer experience has an intensifying effect on the relationship between service remediation perception and corporate image. 4.The consumer experience has an intensifying effect on the relationship between service remediation perception and brand image. Based on the results of the data analyses, this study proposes relevant suggestions for subsequent research and practical application.
Busby, Eric. "The response to and recovery from the 2004 Eastern Bay of Plenty flood event : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Emergency Management at Massey University, Palmerston North, New Zealand." 2010. http://hdl.handle.net/10179/1524.
Full textEdelmann, Bernd Michael Kay. "The effects of bail-ins on bail-out expectations in the European Banking sector." Master's thesis, 2017. http://hdl.handle.net/10400.14/22575.
Full textNa sequência da Grande Recessão, as garantias soberanas e as expectativas de bail out associ-adas causaram uma distorção no custo do financiamento e no comportamento de risco das ins-tituições financeiras. O Banco de Recuperação e Diretiva de Resolução (BRRD) visa alcançar a estabilidade financeira através da transparência e do incentivo à disciplina de mercado. A ferramenta central da BRRD, a fiança, é um mecanismo de repartição de encargos que reafecta o custo. Forçar os acionistas e credores a participar em perdas potenciais deve aumentar o mo-nitoramento moral hazard. Se a diretiva for credível, essas mudanças nas expectativas de resgate devem refletir-se nos preços de segurança. Como as mudanças na regulamentação são introdu-zidas ao longo de vários anos, os efeitos nos preços de mercado são difíceis de observar. Eu venho mostrar que os eventos de resolução recorrente entre 2011 e 2016 em vários países da zona do euro afetaram as expectativas de bail-out, atingindo um nível crítico em 2013. A redu-ção da dívida júnior em Chipre causou reações altamente significativas sobre os valores da carta patente do banco e os spams do CDS. De 2014 a 2016, os efeitos foram inconsistentes e care-ciam de direção. Esta diminuição nas reações do mercado aponta para a realização das expec-tativas de fiança através de compromisso e implementação consistente. As expectativas de fi-ança implicam a antecipação bail-in em caso de instabilidade financeira bancária, o que exige um monitoramento rigoroso e diligente.