Academic literature on the topic 'Recherche de ligands'
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Journal articles on the topic "Recherche de ligands":
Bigot, J., E. Poucet, A. Moreau, C. Hennequin, L. Guillot, H. Corvol, T. Fontaine, and V. Balloy. "Recherche des récepteurs cellulaires et des ligands fongiques impliqués dans la synthèse d’IL-8 par les cellules épithéliales bronchiques infectées par Aspergillus fumigatus." Revue des Maladies Respiratoires 41, no. 3 (March 2024): 208–9. http://dx.doi.org/10.1016/j.rmr.2024.01.056.
Ducy, Patricia. "Recherche ligand désespérément…" médecine/sciences 18, no. 10 (October 2002): 938–40. http://dx.doi.org/10.1051/medsci/20021810938.
Bouchard, L.-P., P. M. Llorca, and M. A. Wolf. "Hypothèses actuelles sur le mécanisme d'action centrale des benzodiazépines." Canadian Journal of Psychiatry 36, no. 9 (November 1991): 660–66. http://dx.doi.org/10.1177/070674379103600907.
de Poulpiquet du Halgouet, Anastasia, Aurélie Darbois, Mansour Alkobtawi, Martin Mestdagh, Virginie Premel, Ludovic Colombeau, Raphaël Rodriguez, et al. "Role of MR1-driven signals and amphiregulin on the recruitment and repair function of skin MAIT cells." Journal of Immunology 210, no. 1_Supplement (May 1, 2023): 61.19. http://dx.doi.org/10.4049/jimmunol.210.supp.61.19.
Bernard, Antoine, David Henault, Sandy Pelletier, Pamela Thebault, Benoit Barrette, and Simon Turcotte. "302 Characterization of TIGIT and PVR expression in colorectal liver metastases." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A325. http://dx.doi.org/10.1136/jitc-2021-sitc2021.302.
Montagner, Miguel Ângelo. "Pierre Bourdieu e a saúde: uma sociologia em Actes de la Recherche en Sciences Sociales." Cadernos de Saúde Pública 24, no. 7 (July 2008): 1588–98. http://dx.doi.org/10.1590/s0102-311x2008000700014.
Massard, V., A. Harlé, L. Uwer, and J. L. Merlin. "Mutations du gène ESR1 : du fondamental à la clinique." Oncologie 21, no. 1-4 (January 2019): 29–32. http://dx.doi.org/10.3166/onco-2019-0027.
De Souza, Galileu Galilei Medeiros. "FILOSOFIA COMO TAREFA." Síntese: Revista de Filosofia 45, no. 141 (April 30, 2018): 113. http://dx.doi.org/10.20911/21769389v45n141p113/2018.
Machinski, Júlio Bernardo. "Modernolatria (Modernolatry)." Cadernos de História 16, no. 25 (December 18, 2015): 396. http://dx.doi.org/10.5752/p.2237-8871.2015v16n25p396.
Vallée, Audrey, Elisabetta Dondi, Jacinthe Bonneau, Christine Leroy, Anne-Gaelle Rio, Marie-Bérengère Troadec, Nadine Varin-Blank, Marie-Dominique Galibert, and Virginie Gandemer. "CD9 Alters Migration and Morphology of CD9-Positive B Acute Lymphoblastic Leukemia Cells." Blood 118, no. 21 (November 18, 2011): 4623. http://dx.doi.org/10.1182/blood.v118.21.4623.4623.
Dissertations / Theses on the topic "Recherche de ligands":
Dagher, Rania Haiech Jacques Pigault Claire. "Recherche de petites molécules bioactives sur la calmoduline outils de recherche pour analyser son rôle dans le signal calcique /." Strasbourg : Université de Strasbourg, 2009. http://eprints-scd-ulp.u-strasbg.fr:8080/1108/01/DAGHER_Rania_2008.pdf.
Le, Manach Claire. "Recherche de ligands du système tubuline/microtubules par chimie combinatoire dynamique." Paris 11, 2008. http://www.theses.fr/2008PA112340.
The system tubulin/microtubules plays a key-role during mitosis and disturbing its dynamic equilibrium can prevent cell division and induce apoptosis. Antitubulin agents are divided into two classes: those that bind to microtubules, stabilizing them and preventing their depolymerization, and those that bind to tubulin dimer, preventing the formation of microtubules. Most of the known antitubulin agents are characterized by a very complex structure, and therefore are relatively hard to synthesize. We planned to use dynamic combinatorial chemistry combined with the reversible formation of imines in water to identify new potential antitubulin agents. This approach is based on the reversible connection between different building blocks to form a chemical library under thermodynamic equilibrium. In the presence of a target, the distribution of the library may be altered, with an amplification for the best binders, which can be detected by an adequate analytical method after fixation of the library’s distribution. We have demonstrated that dynamic combinatorial chemistry is applicable to the dynamic macromolecular system tubulin/microtubules. Using adequate conditions, we have shown that it is possible to target either the tubulin dimer or microtubules. Then we have designed and synthesized two types of scaffolds in order to use them in dynamic libraries. Among the numerous dynamic libraries we prepared some amplifications were identified. Analogues of amplified imines were synthesized and tested on tubulin. Therefore we were able to identify a new class of microtubules ligands and to show that the orientation of two aromatic moieties plays a key role for the type of activity
Mossand, Guillaume. "Recherche de nouveaux ligands pour l'extraction sélective de l'uranium et des terres rares." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV053.
The supply of uranium-based nuclear fuel is a key issue of the electricity production strategy in France, especially as demand for natural uranium will continue to increase in the near future. Rare earths are also considered as strategic metals due to their remarkable properties which make them essential in many applications related to new technologies.There is therefore an interest in developing new, more efficient processes for the extraction of uranium and rare earths than those currently used. The aim is to respond to a permanent increase in demand for raw materials, against the backdrop of the development of new recycling processes, especially for rare earths.Through a multi-scale approach, this PhD thesis sets to develop novel organic ligands with a strong extractant ability for uranyl (UO22+) or for rare earths (TR3+), as well as a high selectivity with respect to various impurities, in particular iron (Fe3+). Thus, many ligands have been designed, synthesized and tested by liquid-liquid extraction in several acidic synthetic media. Bifunctional bi , tri- and pentadentate molecules have been developed and their complexing properties and their speciation in organic medium have been evaluated in the presence of UO22+ and Fe3+ by different approaches (DFT, UV-visible, IR, ESI-MS, EXAFS). Furthermore, several new ligands have been evaluated for the selective extraction of rare earths and the results obtained are remarkable. Overall, these studies have led in some cases to the development of novel molecular designs with excellent extractant properties. Their optimization, coupled with different analytical techniques, fulfilled the objectives of this thesis and will serve in the future to the development of new efficient and selective extractants
Dagher, Rania. "Recherche de petites molécules bioactives sur la calmoduline : Outils de recherche pour analyser son rôle dans le signal calcique." Université Louis Pasteur (Strasbourg) (1971-2008), 2008. https://publication-theses.unistra.fr/public/theses_doctorat/2008/DAGHER_Rania_2008.pdf.
Rogue, Alexandra. "Recherche de gènes cibles de ligands de PPARs et étude de leurs mécanismes d'action." Rennes 1, 2011. http://www.theses.fr/2011REN1B082.
DARDE-IMANI, VALERIE. "Recherche de nouveaux ligands selectifs serotoninergiques : synthese et activite d'analogues fluores de 2-amino-tetralines." Paris 6, 1995. http://www.theses.fr/1995PA066576.
Lawson, Marie. "Recherche de nouveaux ligands du site de la colchicine : Modélisation moléculaire, synthèse et évaluation biologique." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS069.
As part of this work we are interested in discovering new ligands original tubulin inhibitory activity having its polymerization. To do this, rational in silico study is performed to obtain the active molecules in vitro that protein. During this first year of thesis we have developed in collaboration with the modeling team BioCIS - CNRS (Dr. G. Bernadat and Prof. T. Duong Ha.) A virtual screening a chemical library of more than 3 million chemical structures in the ZINC database according to structural descriptors. This screening allowed us to bring out thirty of potentially active molecules. We have already synthesized a quarter of these molecules that are currently being biological evaluation in collaboration with the team of Biochemistry and Structural chemistry of natural substances (Dr. J. Bignon and Dr. J. Dubois) of The Institute Chemistry and Natural Products. For this year, we will continue the synthesis of molecules from this screening in order to assess their activities on tubulin. Depending on the laboratory results, we can also perform pharmacomodulations to improve any potential ligands
Marger, Fabrice. "Implication des canaux calciques de type T dans la douleur viscérale et recherche de ligands." Montpellier 1, 2009. http://www.theses.fr/2009MON1T006.
Poncet-Montange, Guillaume. "Études structurales et fonctionnelles de la NAD Kinase 1 de Listeria monocytogènes : vers une conception rationnelle de ligands utilisant une approche par fragment." Montpellier 1, 2007. http://www.theses.fr/2007MON13505.
The emergence of antibiotic resistance on the one hand, and the immense bulk of data produced by genome sequencing projects on the other, urge to rationalize and accelerate the search for new therapeutic targets. Thus, new methodologies need to be developed to speed up both the biochemical characterization and the determination of potential ligands. Here we used X-ray cristallography with focused combinatorial chemistry as an approach to efficiently determine inhibitors for the NAD kinases 1 from Listeria monocytogenes (NADK1Lm). We determined the high resolution crystallographic complex of NADK1Lm in its free state, and bound to several biological or artificial ligands. Our analysis allowed us 1) to characterize in detail the NAD binding site, 2) to improve the knowledge of the enzymatic mechanism 4) to discover a new nucleotide, the 2’phospho-ATP, with an unknow biological function and 4) to identify the first inhibitor for NADK1Lm, the di-(5’-thio-adenosine)
Podevin, Christelle. "Recherche de nouveaux ligands des récepteurs du système nerveux central : synthèse d'Aza B-norbenzomorphanes et dibenzodiacines à partir de quinoléines." Bordeaux 1, 1998. http://www.theses.fr/1998BOR10626.
Aza B-norbenzomorphans and dibenzodiazecines contain structural features for CNS receptor recognition. They are interesting targets, which could in the future lead to new ligands for opioid receptors imaging. A zinc-acetic acid promoted one pot reaction was proposed, and led to the pentacyclic diamines starting from substituted quinolines. This regio- and sometimes stereoselective reaction allowed us to access to 54 original compounds with good yields. In the same experimental conditions, the 4-picoline methiodide led to an original tetracyclic compound complexed with one molecule of ZnI₂. The whole series was submitted to a pharmacological screening. The results showed that N-acetyl aza B-norbenzomorphans produce a dose-dependent activity on opioid receptors while the N-allyl ones exhibit affinity for α-2 receptors
Books on the topic "Recherche de ligands":
1961-, Keen Mary, ed. Receptor binding techniques. Totowa, N.J: Humana Press, 1999.
Aliata, Fernando Rodolfo, and Eduardo César Gentile, eds. El modelo <i>beaux-arts</i> y la arquitectura en América Latina, 1870-1930. Facultad de Arquitectura y Urbanismo (UNLP), 2022. http://dx.doi.org/10.35537/10915/138879.
Book chapters on the topic "Recherche de ligands":
Rampe, David, and David J. Triggle. "New synthetic ligands for L-type voltage-gated calcium channels." In Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, 191–238. Basel: Birkhäuser Basel, 1993. http://dx.doi.org/10.1007/978-3-0348-7147-1_7.
Freidinger, Roger M. "Toward peptide receptor ligand drugs: Progress on nonpeptides." In Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, 33–98. Basel: Birkhäuser Basel, 1993. http://dx.doi.org/10.1007/978-3-0348-7147-1_4.
Leurs, R., R. C. Vollinga, and H. Timmerman. "The medicinal chemistry and therapeutic potentials of ligands of the histamine H3 receptor." In Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques, 107–65. Basel: Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-7164-8_4.