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Books on the topic 'Receptor affinity'

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Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2023

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1

Ghaderi, Abbas Ali. Functional study of the low affinity IgE receptor (Fc[epsilon]RII/CD23) on human B lymphocytes. Birmingham: University of Birmingham, 1990.

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2

H, Gronemeyer, ed. Affinity labelling and cloning of steroid and thyroid hormone receptors. Weinheim, Federal Republic of Germany: VCH, 1988.

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3

Naples, Mark. Determinants of high affinity ligand binding to the group III metabotropic glutamate receptors. Ottawa: National Library of Canada, 2001.

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4

Clarke, Wendy Elizabeth. Intracellular compartmentalisation of fibroblast growth factor-2 and associated high and low affinity receptors after cerebral injury to the adult rat brain. Birmingham: University of Birmingham, 1999.

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5

Marelius, John. Computational Prediction of Receptor-Ligand Binding Affinity in Drug Discovery. Uppsala Universitet, 2000.

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6

Sardinia, Michael Francis. AT₄ receptor binding characteristics: A study of the structural requirements of the angiotensin IV peptide requisite for high affinity, specific ligand-receptor interaction. 1994.

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7

Verotoxin-globotriosylceramide binding: Receptor affinity purification and the effect of membrane environment on toxin binding. Ottawa: National Library of Canada, 1993.

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8

Khan, Samina E. An investigation of structure activity effects of D-ring substitution of estradiol on estrogen receptor affinity. 1992.

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9

Ren, Ke, and Ronald Dubner. The first crystal structure of an ionotropic glutamate receptor ligand-binding core. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0032.

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The known functional ionotropic glutamate receptors (iGluRs) are composed of three major subtypes: AMPA, NMDA, and kainate. In 1998, in the landmark paper discussed in this chapter, Armstrong et al. provided the first crystal structure of an iGluR-subunit ligand-binding core, the S1S2 region of the rat GluA2 ‘flop’ isoform. They solved its structure with X-ray crystallography from selenomethonine crystals. They also identified residues involved in kainate binding, analysed allosteric sites that regulate affinity and specificity of the agonist, and mapped potential subunit–subunit interaction sites. They also proposed that binding of different agonists may result in variable degrees of domain closure. This work has profound impact on the field and it has been importantly cited. Subsequently, numerous high-resolution crystal structures of ligand-binding domains of iGluRs in complex with ligands, both agonists and antagonists, have been solved.

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10

Vitamin D3 Analogues with Low Vitamin D Receptor Binding Affinity Regulate Chondrocyte Proliferation, Proteoglycan Synthesis, and Protein Kinase C Activity. Storming Media, 1997.

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11

Cavacuiti, Christopher. The Pharmacology of Opioids (DRAFT). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190265366.003.0008.

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This chapter focuses on the attributes of and component medications within the class of opioids, emphasizing kinetics, dynamics, and therapeutic and adverse effects. To help patients make informed decisions about opioid use, the clinicians prescribing these medications must be able to explain when opioids are likely to help and when they are likely to do harm. Subclasses of opioids include phenanthrenes, benzomorphans, phenylpiperidines, and diphenylheptanes; examples are given of each, with respective utilities and limitations. A discussion then follows of pharmacodynamics, pharmacokinetics, opioid receptor affinity, metabolism, and drug interactions. Tables and figures amplifying the text include: opioid class by synthetic method (Table 8.1); common physiological effects by opioid receptor subtypes (Table 8.2); opioid activity (Table 8.3); and a listing of figures and tables located in Appendix B (opioid receptor affinity, respiratory depression with opioids, adverse effects, metabolism, pharmacogenetics, extended release/long-acting opioids, abuse deterrent formulations). A text box provides supplemental resources.

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12

Chappel, Marie Suzanne. Localization and characterization of the molecular components contributing to the high affinity Fc gamma receptor binding site within human immunoglobin G. 1994.

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13

Test No. 493: Performance-Based Test Guideline for Human Recombinant Estrogen Receptor (hrER) In Vitro Assays to Detect Chemicals with ER Binding Affinity. OECD, 2015. http://dx.doi.org/10.1787/9789264242623-en.

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14

Affinity and Efficacy. World Scientific Publishing Company, 2011.

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15

Sprouse, Adrienne. Toxins (DRAFT). Edited by Madeleine M. Castellanos. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190225889.003.0010.

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This chapter describes the categories of 300+ environmental chemicals measured in the blood and urine of Americans by the US Centers for Disease Control and Prevention. Some are endocrine-disrupting chemicals (EDCs) and substitute for endogenous hormones in a variety of metabolic processes affecting sexual health, obesity, diabetes, and behavior. The Monotonic Dose-Response (linear dose-response) is inappropriate when evaluating the health consequences of EDCs. Nonmonotonic Dose-Response Curves are better for considering the affinity of the ligand for the receptor, receptor saturation, ligand specificity, and tissue specificity of the receptor distribution. These factors combine to explain why ambient levels of many environmental chemicals cause damage to tissues or development and why low-level exposures can create disease different from higher level exposures. Exposure during critical stages of fetal development may cause permanent changes not apparent until adulthood. Environmental chemicals that are not EDCs may harm by altering genetic material and causing apoptosis.

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16

McCormick, Patrick Neil. Pre-clinical evaluation of [carbon-11]-(+)-PHNO as an agonist positron emission tomography (PET) radiotracer for imaging of the high-affinity state of the dopamine D2 receptor. 2006.

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17

Fridman, W. H., ed. Structures and Functions of Low Affinity Fc Receptors. S. Karger AG, 1989. http://dx.doi.org/10.1159/isbn.978-3-318-01919-3.

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18

H, Fridman Wolf, ed. Structures and functions of low affinity Fc receptors. Basel: Karger, 1989.

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19

Maeda, Dean Yoshimasa. Synthesis and evaluation of affinity labels based on peptide antagonists for delta opioid receptors. 1997.

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20

Leelasvatanakij, Leena. Synthetic strategies for the preparation of affinity label dynorphin A(1-11)NH₂ analogues. 1996.

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21

Structures and Functions of Low Affinity Fc Receptors (Chemical Immunology). S. Karger AG (Switzerland), 1990.

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22

Guo, Li. Affinity and efficacy studies of buprenorphine analogues at opioid receptors. 1996.

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23

Lebaron, Frédéric, and Brigitte Le Roux. Bourdieu and Geometric Data Analysis. Edited by Thomas Medvetz and Jeffrey J. Sallaz. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780199357192.013.22.

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Chapter abstract The extent to which the concepts of field and social space are linked to a concrete mode of empirical research—and in particular to a set of original statistical tools—has seldom been acknowledged. This chapter aims to re-establish the close link between the field concept and geometric data analysis (GDA), Bourdieu’s preferred technique for mapping the “social distances” between individuals. The elective affinity between the two is based on a relation of tight interdependence: on the one hand, the emergent practice of GDA sustains and strengthens the “implicit philosophy” of the theory of fields; on the other hand, the method’s widespread use by Bourdieu and his collaborators has facilitated GDA’s international reception in the social sciences. The chapter concludes by discussing the empirical research program that results from wedding a sociology of fields with the systematic use of GDA.

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24

Reynolds, Benjamin E. John among the Apocalypses. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198784241.001.0001.

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The central place of revelation in the Gospel of John and the Gospel’s revelatory telling of the life of Jesus are distinctive features of John when compared with the Synoptic Gospels; yet, when John is compared among the apocalypses, these same features indicate John’s striking affinity with the genre of apocalypse. By paying attention to modern genre theory and making an extensive comparison with the standard definition of “apocalypse,” the Gospel of John reflects similarities with Jewish apocalypses in form, content, and function. Even though the Gospel of John reflects similarities with the genre of apocalypse, John is not an apocalypse, but in genre theory terms, John may be described as a gospel in kind and an apocalypse in mode. John’s narrative of Jesus’s life has been qualified and shaped by the genre of apocalypse, such that it may be called an “apocalyptic” gospel. Understanding the Fourth Gospel as “apocalyptic” Gospel provides an explanation for John’s appeal to Israel’s Scriptures and Mosaic authority. Possible historical reasons for the revelatory narration of Jesus’s life in the Gospel of John may be explained by the Gospel’s relationship with the book of Revelation and the history of reception concerning their writing. An examination of Byzantine iconographic traditions highlights how reception history may offer a possible explanation for reading John as “apocalyptic” Gospel.

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