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1
Akula, Kavitha. "Expanding the Spiroligomers Toolbox as Protein-Protein Interaction Inhibitors." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/422281.
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ChemistryPh.D.
This work presents the application of spiroligomers as inhibitors of protein-protein interactions. After the discovery of an acyl-transfer coupling reaction by Dr. Zachary Brown, a previous graduate student of Schafmeister group, the synthesis of highly functionalized spiroligomers that mimic the helical domain of p53 was undertaken before each molecule was tested for binding to HDM2, a natural binding partner of p53. A library of molecules was synthesized on solid support that altered the stereochemistry along the spiroligomer as well as the presented functional groups. It was determined that spiroligomers enter human liver cancer cells through passive diffusion and induces a biological response in both a dose- and time-dependent manner. The synthesis of additional spiroligomer analogues achieved low micromolar to high nanomolar range activity during screening in direct and competitive binding assays. In parallel to the project above, a series of spiroligomers that mimic the side chains of the leucine zipper region of Max were synthesized in an effort to disrupt the interaction of the protein with c-Myc. The series of compounds contained various stereocenter combinations and different functional groups as before but were made in solution before testing for inhibition. Initial binding assays resulted in low micromolar activity, however, secondary assays (ELISA and cellular assays) did not confirm the inhibitory effect of spiroligomers on the c-Myc/Max heterodimer. In summary, this work illustrates that spiroligomers are capable mimics of helical peptides and can induce a biological response.
Temple University--Theses
2
Kelly, Elyse. "Maid for Man." Honors in the Major Thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1605.
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This thesis is a novella highlighting the struggle many religious individuals face to maintain a faith with or without physical props and boundaries, and why some people voluntarily live with pharisaical rules that make it harder to reside in the modern world. Maid for Man is the story of Caty, a young woman brought up by the strict conservatism of a combined church and homeschool group, who, after marrying a man and discovering he has no physical interest in her, must decide whether or not to divorce him, even though her family and community believe divorce is an excommunicable sin.B.A.
Bachelors
Arts and Humanities
English; Creative Writing
3
Debroy, Saptarshi. "Spectrum Map and its Application in Cognitive Radio Networks." Doctoral diss., University of Central Florida, 2014. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/6265.
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Recent measurements on radio spectrum usage have revealed the abundance of underutilized bands of spectrum that belong to licensed users. This necessitated the paradigm shift from static to dynamic spectrum access. Cognitive radio based secondary networks that utilize such unused spectrum holes in the licensed band, have been proposed as a possible solution to the spectrum crisis. The idea is to detect times when a particular licensed band is unused and use it for transmission without causing interference to the licensed user. We argue that prior knowledge about occupancy of such bands and the corresponding achievable performance metrics can potentially help secondary networks to devise effective strategies to improve utilization.
In this work, we use Shepard's method of interpolation to create a spectrum map that provides a spatial distribution of spectrum usage over a region of interest. It is achieved by intelligently fusing the spectrum usage reports shared by the secondary nodes at various locations. The obtained spectrum map is a continuous and differentiable 2-dimension distribution function in space. With the spectrum usage distribution known, we show how different radio spectrum and network performance metrics like channel capacity, secondary network throughput, spectral efficiency, and bit error rate can be estimated. We show the applicability of the spectrum map in solving the intra-cell channel allocation problem in
centralized cognitive radio networks, such as IEEE 802.22. We propose a channel allocation scheme where the base station allocates interference free channels to the consumer premise equipments (CPE) using the spectrum map that it creates by fusing the spectrum usage information shared by some CPEs. The most suitable CPEs for information sharing are chosen on a dynamic basis using an iterative clustering algorithm. Next, we present a contention based media access control (MAC) protocol for distributed cognitive radio network. The unlicensed secondary users contend among themselves over a common control channel. Winners of the contention get to access the available channels ensuring high utilization and minimum collision with primary incumbent. Last, we propose a multi-channel, multi-hop routing protocol with secondary transmission power control. The spectrum map, created and maintained by a set of sensors, acts as the basis of finding the best route for every source destination pair. The proposed routing protocol ensures primary receiver protection and maximizes achievable link capacity.
Through simulation experiments we show the correctness of the prediction model and how it can be used by secondary networks for strategic positioning of secondary transmitter-receiver pairs and selecting the best candidate channels. The simulation model mimics realistic distribution of TV stations for urban and non-urban areas. Results validate the nature and accuracy of estimation, prediction of performance metrics, and efficiency of the allocation process in an IEEE 802.22 network. Results for the proposed MAC protocol show high channel utilization with primary quality of service degradation within a tolerable limit. Performance evaluation of the proposed routing scheme reveals that it ensures primary receiver protection through secondary power control and maximizes route capacity.Ph.D.
Doctorate
Electrical Engineering and Computing
Engineering and Computer Science
Computer Engineering
4
Alfattani, Safwan. "Indirect Methods for Constructing Radio Environment Map." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35666.
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To solve the spectrum scarcity problem caused by the high number of wireless applications and users, the concept of cognitive radio (CR) was proposed in the past few years. Cognitive radio networks (CRNs) provide dynamic spectrum access (DSA), where the unlicensed users can access the spectrum without causing unacceptable level of interference to the primary user (PU). DSA was based on conventional spectrum sensing information or geolocation databases. Later,
radio environment map (REM) as an improved geolocation database was introduced to enhance the DSA process. It is a comprehensive map consists of different integrated databases, and the interference field information is one of its databases.
In this thesis, a description of the REM concept and its construction methods will be
presented. The focus will be for the indirect methods for constructing interference map, which represents a layer of the REM. Indirect method refers to the methods that utilize known model information, to first estimate the primary transmitter parameters and then generate REM. Two indirect methods under lognormal shadowing were presented and compared. The better of these two methods is further investigated in different scenarios. These scenarios include different
number of sensors, varied size of measurements, several shadowing spread values, different percentages of error in path-loss exponent, and the effect of the number of moving sensors and their speeds to the REM quality. The performance is evaluated using these metrics: “localization error, signal power error and correct detection zone ratio (CDZR). The results show that performance is enhanced as the number of sensors and the size of measurements increase, whereas clear degradation in REM quality is shown when shadowing spread increases or the model parameters are not well calibrated. Also, as the number of moving sensors or their speeds
increase, the REM performance becomes less effective
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Banister, Susan H. "Regenerating gene (reg) expression : studies in the BB rat and man." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296263.
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Gómez, E. Luis. "Plataforma de intercambio red mar y tierra : infraestructura para la transferencia marítima terrestre de pasajeros en el borde mar." Tesis, Universidad de Chile, 2012. http://www.repositorio.uchile.cl/handle/2250/112603.
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ArquitectoEl presente proyecto busca consolidar el intercambio modal del Archipiélago, entre las Islas Menores y la Isla Grande de Chiloé. Esto, mediante infraestructura que facilite la movilidad, coordinando eficientemente cambio modal del transporte. Así se otorgará y realzara la vocación de intercambio que posee el borde mar chilote, identificando su estructura organizativa y funcional, clasificando las distintas escalas de intercambio que se desarrollan en el borde.
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Louw, Ronald Hayward. "Criminal negligence and mens rea : is the reasonable man test an unreasonable one?" Master's thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/17317.
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Includes bibliographical references.In this essay I shall explore the various pertinent components of the test for criminal negligence paying particular attention to the issues raised above, namely, the pure objective test, the notion of the reasonable man, the relative objective test, circumstances external to the actor, and the subjective test. In doing so I shall critically consult and review the writings of various South African writers on the topic as well as the courts' handling of the test and its attendant practical and theoretical difficulties. For the sake of completeness and clarity certain other closely related issues will be explored, namely, whether the test for negligent delictual liability is applicable in criminal law, and the distinction between and nature of unlawfulness and mens rea in negligence crimes. These latter issues, which will not be developed as fully, serve as a necessary component of any discussion on the central question in this essay, namely, the justness and fairness of determining criminal negligence by means of the objective reasonable man test.
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Adams, Leanne M. "MOLECULAR TYPING OF MYCOBACTERIAL ISOLATES CULTURED FROM THE TISSUE OF INFLAMMATORY BOWEL DISEASE (CROHN'S DISEASE) PATIENTS." Master's thesis, University of Central Florida, 2004. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4450.
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The role of Mycobacterium avium subsp paratuberculosis (MAP) in the etiology and pathogenesis of inflammatory bowel disease (IBD) including Crohn's Disease (CD), has been investigated. The fastidious characteristics and cross reactivity of MAP with other members in Mycobacteria have produced significant challenges in their detection and identification. In this two year pilot study, an array of three PCR molecular assays based on the detection of sequences from the16S rRNA, IS1245, and IS900 genes, belonging to members of the MAC, have been developed and optimized into a common protocol to be used as a rapid and accurate diagnostic tool regarding M. avium complex (MAC) infection. The PCR protocol time was reduced by half, and the sensitivity and specificity of the molecular assays has been significantly improved barring the need for southern hybridization. This improved methodology was employed for the molecular typing of MAC in 100 resected, full-thickness tissue samples removed from IBD patients. The tissue samples were homogenized, decontaminated, and inoculated into two mycobacterial culture media systems. A total of 328 Bactec and Mycobacteria Growth Indicator Tube (MIGT) cultures were evaluated for positive MAC growth. Harvested cells were then subjected to genomic DNA extraction and subsequent PCR typing. The I6 S rRNA-based PCR resulted in detection of 26/28 (93%) MAC in Bactec cultures. Specifically, 25/28 (89%) of positive MAC indicated the presence of IS1245 specific to M. avium subsp avium (MAV), and 6/28 (21%) produced results consistent with the presence of IS900 following nested PCR. Moreover, 20/100 (20%) of MGIT cultures were positive for MAP. Sequence analysis was performed on amplified regions of the IS900 element from seven isolates. A nucleotide alignment revealed that 2/7 isolates demonstrated 100% homology to Bovine MAP and 5/7 isolates showed 96-99% homology to sequenced Bovine MAP published in GenBank. The detection of at least two Bovine derived MAP in IBD tissue will have great impact on the epidemiology and reclassification of IBD. The significant homology of the other five isolates to Bovine derived MAP suggests a diversity in the geographical distribution of MAP regarding Johne's disease and CD. Ultimately, the etiology, diagnosis, and the treatment of IBD as well as control and prevention measures may be enhanced with better tools for investigating emerging infectious diseases.M.S.
Department of Molecular Biology and Microbiology
Health and Public Affairs
Molecular Biology and Microbiology
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Driscoll, Nicholaus D. "Geologic Map of the Deer Point Quadrangle, Garfield County, Utah." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3276.
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A new geologic map of the Deer Point 7.5' quadrangle located in the southern region of Capitol Reef National Park in south-central Utah provides stratigraphic and structural detail not previously available. The Deer Point quadrangle was mapped at a scale of 1:24,000 and is the fourth geologic map completed at this scale in Capitol Reef National Park. Twelve Quaternary units and eighteen bedrock formations and members are exposed in the Deer Point quadrangle. Bedrock formations range in age from Triassic to Cretaceous. The details not available on previous geologic maps include: four alluvial terrace units, two lacustrine units, two mass movement units, and members of the Moenkopi, Chinle, and Carmel Formations. Historically the Page Sandstone has been mapped as part of the Navajo Sandstone or the Carmel Formation. This map identifies the Page Sandstone as a separate and independent unit. The Deer Point quadrangle is cross cut by a portion of a Laramide-age, basement cored, NNW-SSE trending asymmetrical anticline called the Waterpocket Fold. Strikes and dips measured throughout the Deer Point quadrangle identify the vergence of the anticline as eastward with a maximum dip of 49˚ on the forelimb and 7˚ on the backlimb. The maximum dip on the forelimb dramatically decreases in the southern quarter of the quadrangle to 15˚.The Utah Geological Survey is mapping the Hite Crossing 30' x 60' quadrangle at a scale of 1:62.500. The Deer Point quadrangle is one of 32 quadrangles that comprise the Hite Crossing quadrangle. The Utah Geological Survey is working to establish erosion rates on the Colorado Plateau. To do this, they are dating alluvial terrace deposits. Within the Deer Point quadrangle four new terrace levels have been identified that could help with this research. Additional research could use these terrace deposits to better understand erosion rates in the Deer Point quadrangle and the broader Colorado Plateau. Numerous mass movement deposits are found within the Deer Point quadrangle. The largest has been named the Red Slide. Several aspects of the Red Slide are identified including classification, breakaway zone, source, deposit size, composition, debris flow path and depositional history. The Red Slide has been classified as a debris flow. The breakaway zone is a concave cliff 1.5 miles (2.4 km) to the west of the debris flow's present location. The flow's scarp is no longer identifiable. The source of the debris flow material is the Chinle Formation and Wingate Sandstone. The Red Slide deposit covers an area of over 16.6 million ft2 (~1.5 million m2). The toe of the debris flow is 1 mile (1.6 km) wide. The estimated maximum thickness of the debris flow is sixty meters. The Red Slide is composed of fine-grained, clay- and silt- sized material, and a small amount of angular pebble- to cobble-sized limestone clasts from the Owl Rock Member of the Chinle Formation. Boulder- to sand-sized grains from the Wingate Sandstone are scattered throughout the deposit with the larger grains forming inversely grading packages. The Red Slide likely occurred as a series of large debris flows, not one catastrophic event, although they may have occurred at about the same time.
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Barth, Timothy. "INFLUENCE MAP METHODOLOGY FOR EVALUATING SYSTEMIC SAFETY ISSUES." Doctoral diss., University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3271.
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"Raising the bar" in safety performance is a critical challenge for many organizations. Contributing factor taxonomies organize information on why accidents occur. Therefore, they are essential elements of accident investigations and safety reporting systems. Organizations must balance efforts to identify causes of specific accidents with efforts to evaluate systemic safety issues in order to become more proactive about improving safety. This research successfully addressed two problems: (1) limited methods and metrics exist to support the design of effective taxonomies, and (2) influence relationships between contributing factors are not explicitly modeled within a taxonomy. The primary result of the taxonomic relationship modeling efforts was an innovative "dual role" contributing factor taxonomy with significant improvements in comprehensiveness and diagnosticity over existing taxonomies. The influence map methodology was the result of a unique graphical and analytical combination of the dual role taxonomy and influence relationship models. Influence maps were developed for several safety incidents at Kennedy Space Center. An independent assessment was conducted by a team of experts using the new dual role taxonomy and influence chain methodology to evaluate the accuracy and completeness of contributing factors identified during the formal incident investigations. One hundred and sixteen contributing factors were identified using the influence map methodology. Only 16% of these contributing factors were accurately identified with traditional tools, and over half of the 116 contributing factors were completely unaddressed by the findings and recommendations of the formal incident reports. The new methodology is being applied to improve spaceport operations and enhance designs of future NASA launch systems.Ph.D.
Department of Industrial Engineering and Management Systems
Engineering and Computer Science
Industrial Engineering and Management Systems
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Chaffee, Dorey. "Truly Accomplished: Exploratory Study of Success Map Development." Honors in the Major Thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/938.
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The current study examined Truly Accomplished (TA), an intervention designed to help individuals develop personalized systems to measure and improve behavior by utilizing well-established principles and research on motivation, participation and feedback. This study focused on participation during Success Map development (an integral step in the TA process) and the impact of using experts to develop Success Maps in the TA system. Using the context of fitness, 40 female participants were randomly assigned to either complete the regular TA process, developing their own Success Maps, or the modified TA process, using expert-developed Success Maps. A repeated-measures design with one between-subjects independent variable was used to measure overall effectiveness scores, changes in fitness performance (plank, wall-sit, push-ups, curl-ups) and body composition (BMI, percent body fat), attitudes of system development, satisfaction with TA and satisfaction with life. Additionally, the similarities between expert and self-developed Success Maps were compared. Across all participants, large gains in effectiveness were found, including significant increases in all measurers of fitness performance; however, attitudes were poorer when Success Maps were developed by experts. Moreover, there were differences between expert and self-developed Success Maps. Results support TA as an effective intervention for positive behavior change. The practical and theoretical implications of the differences found between conditions are discussed.B.S.
Bachelors
Sciences
Psychology
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Ma, Liang. "Genetic studies for aquaculture and stock-enhancement of red drum (Sciaenops ocellatus)." Texas A&M University, 2003. http://hdl.handle.net/1969.1/6012.
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Hypervariable, nuclear-encoded microsatellites were used to (i) estimate genetic
effective size (Ne) of red drum spawning over a two-week period in nine brood tanks at a
TPWD hatchery; (ii) estimate heritability of early-larval growth and of growth rate and
cold tolerance of juveniles; and (iii) test Mendelian segregation and independent
assortment of 31 nuclear-encoded microsatellites. Assuming all tanks contributed
equally to an offspring population, the maximum (expected) and observed Ne over the
nine brood tanks was 43.2 and 27.0, respectively. The estimate of Ne based on
observed variation in family size was 19.4. Simulations indicated that over a limited
time period the simplest approach to maximizing Ne for a release population would be to
utilize equal numbers of progeny from each brood tank. A family (genetic) effect was
found to contribute significantly to the variance in early larval growth, juvenile growth
rate, and cold tolerance. Estimates of narrow-sense heritability for these three traits
were 0.07 +- 0.03, 0.52 +- 0.21 and 0.20 +- 0.10 (two growth intervals measured), and 0.30 +- 0.11, respectively, under the genetic models employed. The relatively low estimate
of heritability for early larval growth suggests that genetic improvement for this trait
likely would be slow. The heritability estimates for juvenile growth rate and cold
tolerance, alternatively, suggest that genetic selection for these traits could be effective. Segregation at all 31 microsatellites fit Mendelian expectations for autosomal loci; a null
allele was inferred at two of the microsatellites. Results from pairwise tests of
independent assortment demonstrated that 20 of the 31 microsatellites could be placed
into seven linkage groups. Additional linkage groups inferred from a prior study
increased the number of inferred linkage groups in red drum to nine, with a range of two - five (avg. = 2.78) microsatellites in each linkage group. The remaining 11
microsatellites tested in this study assorted independently from all other microsatellites,
suggesting the possibility of 11 additional linkage groups.
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Neeld, Lisa. "Mad Cows and Mad People: Analyzing Governmental Liability in the Event of a BSE Outbreak and the Ethical Implications for Governance in Our Country." Honors in the Major Thesis, University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/981.
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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.Bachelors
Office of Undergraduate Studies
Liberal Studies
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Caulkins, Bruce. "SESSION-BASED INTRUSION DETECTION SYSTEM TO MAP ANOMALOUS NETWORK TRAFFIC." Doctoral diss., University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3466.
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Computer crime is a large problem (CSI, 2004; Kabay, 2001a; Kabay, 2001b). Security managers have a variety of tools at their disposal – firewalls, Intrusion Detection Systems (IDSs), encryption, authentication, and other hardware and software solutions to combat computer crime. Many IDS variants exist which allow security managers and engineers to identify attack network packets primarily through the use of signature detection; i.e., the IDS recognizes attack packets due to their well-known "fingerprints" or signatures as those packets cross the network's gateway threshold. On the other hand, anomaly-based ID systems determine what is normal traffic within a network and reports abnormal traffic behavior. This paper will describe a methodology towards developing a more-robust Intrusion Detection System through the use of data-mining techniques and anomaly detection. These data-mining techniques will dynamically model what a normal network should look like and reduce the false positive and false negative alarm rates in the process. We will use classification-tree techniques to accurately predict probable attack sessions. Overall, our goal is to model network traffic into network sessions and identify those network sessions that have a high-probability of being an attack and can be labeled as a "suspect session." Subsequently, we will use these techniques inclusive of signature detection methods, as they will be used in concert with known signatures and patterns in order to present a better model for detection and protection of networks and systems.Ph.D.
Other
Arts and Sciences
Modeling and Simulation
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Angel, Samanatha. "Music and paleolithic man the soundtrack of human cognitive development." Honors in the Major Thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/651.
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Archaeologists have pored over countless texts of the ancient civilizations, attempting to piece together bygone worlds. However, relatively little work has been done to reconstruct the musical history of these societies, and even less on why their musical histories are important. This paper aims at a synthesis between the ancient Egyptian and classical Greek archaeological records to analyze the importance of music in Paleolithic human cognitive development. Countless musical instruments have been discovered globally, ranging from pre-Columbian bone flutes in Oaxaca, Mexico to ancient trumpets in Egyptian burials (Barber et al 2009). Apart from their place in a museum, minimal work has been done to ascertain their importance to human society as a whole. This thesis attempts to display the crucial need for more research in this field. The recent decline in support for arts education in favor of 'hard sciences' and mathematics is deeply disturbing; the history of humanity should be important not only to anthropologists and historians, but to members of all disciplines. This lack of interest in 'soft sciences' and the arts may lead to a complete loss of ancient musical history; a loss that would be devastating to history, anthropology and the worlds. The contents of this paper portray both the ancient importance of music, and how it contributed to increased cognitive faculties during hominid development.B.A.
Bachelors
Sciences
Anthropology
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Benigni, Amanda. "From man to meteor Nineteenth century American writers and the figure of John Brown /." Huntington, WV : [Marshall University Libraries], 2007. http://www.marshall.edu/etd/descript.asp?ref=811.
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Arias, De La Cruz Joseph William. "Diseño de una red FTTH utilizando el estándar GPON para el distrito de Magdalena del Mar." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2015. http://tesis.pucp.edu.pe/repositorio/handle/123456789/7506.
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La presente tesis busca lograr un mayor acceso a la banda ancha en el distrito de
Magdalena del Mar y con ello acortar la diferencia de acceso a la banda ancha fija que
existe en el Perú, en comparación a los demás países de Sudamérica como Uruguay
(23%), Argentina (15%) y Chile (13%). Para lograrlo, se propone un diseño de red
FTTH con estándar GPON el cual brindará un servicio con velocidades altas de carga
y descarga, una red confiable debido a su red redundante y costos accesibles para el
usuario del hogar.
Para ello en el primer capítulo se realizará un diagnóstico de la situación actual
respecto de los servicios de telecomunicaciones y el nivel socio económico del distrito.
En el segundo capítulo, se desarrollará toda la teoría correspondiente a la tesis para
entender los conceptos básicos necesarios para el diseño de la red. En el tercer
capítulo, se mostrará toda la ingeniería de red, donde se explicarán los pasos que se
realizaron para diseñar la red FTTH; así como, el dimensionamiento de las potencias y
las tasas de transferencias en la red. Y por último, se realizará un análisis económico
en donde se plantea un horizonte temporal de 5 años para recuperar lo invertido y
generar rentabilidad.
Al final de la presente tesis, se mostrará las conclusiones a las cuales se llegó a lo
largo del desarrollo del diseño de la red FTTH con estándar GPON para el distrito de
Magdalena del Mar.Tesis
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Geller, Alexander C. "Thermal Imaging of RDCs and the Characterization of an Operating Map for a Novel RDC Geometry." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin161368598622062.
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Egan, Brenna M. "The battered man : an evaluation of equal justice under the law." Honors in the Major Thesis, University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1401.
Full textAbstract:
This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.Bachelors
Health and Public Affairs
Legal Studies
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Rakshit, Sudipta. "ACCESS GAMES: A GAME THEORETIC FRAMEWORK FOR FAIR BANDWIDTH SHARING IN DISTRIBUTED SYSTEMS." Doctoral diss., University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2444.
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In this dissertation, the central objective is to achieve fairness in bandwidth sharing amongst selfish users in a distributed system. Because of the inherent contention-based nature of the distributed medium access and the selfishness of the users, the distributed medium access is modeled as a non-cooperative game; designated as the Access Game. A p-CSMA type medium access scenario is proposed for all the users. Therefore, in the Access Game, each user has two actions to choose from: "transmit" and "wait". The outcome of the Access Game and payoffs to each user depends on the actions taken by all the users. Further, the utility function of each user is constructed as a function of both Quality of Service (QoS) and Battery Power (BP). Various scenarios involving the relative importance of QoS and BP are considered. It is observed that, in general the Nash Equilibrium of the Access Game does not result into fairness. Therefore, Constrained Nash Equilibrium is proposed as a solution. The advantage of Constrained Nash Equilibrium is that it can be predicated on the fairness conditions and the solution will be guaranteed to result in fair sharing of bandwidth. However, Constrained Nash Equilibrium is that it is not self-enforcing. Therefore, two mechanisms are proposed to design the Access Game in such a way that in each case the Nash Equilibrium of the Access Game satisfies fairness and maximizes throughput. Hence, with any of these mechanisms the solution of the Access Game becomes self-enforcing.Ph.D.
School of Computer Science
Arts and Sciences
Computer Science
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Prathep, Anchana. "Population ecology of a turf-forming red alga, Osmundea pinnatifida from the Isle of Man, British Isles." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250454.
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Stone, Thomas. "Rewriting the "Great Man" Theory: Historiographic Critique in Spanish American Literature." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/489746.
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SpanishPh.D.
This dissertation is a survey of postmodern historical fiction in 20th and 21st century Spanish American literature. It has diverse manifestations, but the defining characteristic of this kind of historical fiction is a rejection of any rigid distinction between historical and fictional discourse. This is a descriptive rather than a normative study: it examines how eight different authors use the techniques of postmodern historical fiction to develop implicit critiques of the “great man” theory of history. The Scottish writer Thomas Carlyle popularized this theory in the 1800s, and it asserts that biography is the proper model for history, namely, the biography of prominent individuals – “great men.” It treats these people as the source of history. Opposing this historiographic ideology, many authors of postmodern historical fiction see such figures as subjects that can be “written” and “re-written”; they are not the source of history, but the product of historical discourse. I conduct close readings of nine primary texts to elucidate how they challenge the “great man” historiography of four significant figures from Spanish American history: Montezuma, Simón Bolívar, Christopher Columbus, and Ernesto “Che” Guevara. I conclude that the historiographic critiques in these texts converge around three common strategies in their critiques: an extension of character from the domain of fiction to the domain of history, the subversion of the literary genres of biography and autobiography, and a commitment to rewriting the traditional narratives of specific historical events.
Temple University--Theses
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Elmore, Ashley Michelle. "The New Man and the New Lad: Hegemonic Masculinities in Men's Lifestyle Magazines." Master's thesis, University of Central Florida, 2004. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4482.
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Men are bombarded with contradictory masculine imagery in the media. The perfect man must be aggressive but not violent, sensitive but not emotional, healthy, active and smart without being an idealist, overachiever or too bookish. Heterocentric male focused lifestyle magazines rival women's magazines in number and availability. Some men look to these images as a tool by which to gauge their masculinity and learn their social role performance. This inquiry includes a content analysis of four major men's lifestyle magazines over a 12-month period in which four new masculinities: certitude, irony, new sexism and double voicing were critiqued. Elements of costume, nonverbal expressions and activity level in the photographs of men and women were examined. The findings indicate that Maxim and Stuff were deluged with displays of certitude of gender roles, irony, new sexism and double voicing. Playboy had a high level of gender certitude, marginal levels of new sexism and irony and low levels of double voicing. Lastly, GQ had relatively high levels of gender certitude but it had very low levels of the other masculinities.M.A.
Department of Sociology and Anthropology
Arts and Sciences
Sociology and Anthropology
24
Auz, Jessica. "Man vs beast the human-animal boundary in J.K. Rowling's Harry Potter series." Honors in the Major Thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/6.
Full textAbstract:
In her series of seven novels, Rowling constructs a society and a framework of characterization that allows her to explore the human-animal boundary in a variety of ways. She connects her novels to the ideology of the classical and medieval periods while still acknowledging the ways that the relationship between humans and animals has changed over the years by showcasing the influence of modern popular culture on her characterization of the human-animal boundary. Through her descriptions of werewolves, Patronuses, Animagi, and Harry Potter's and Lord Voldemort's abilities to speak Parseltongue, Rowling uses classical, medieval, and modern animal symbolism to showcase her characters' personalities. These human-animal frameworks associate particular imagery with each character, and this imagery highlights the core of the character. By using this symbolism to showcase her characters' deepest characteristics, Rowling also delineates her heroes and villains through their relationships with the boundary between humans and animals. This thesis analyzes the ways that Rowling's fusion of classical, medieval, and modern animal symbolism contributes to Rowling's characterization of heroes and villains throughout the series. By examining the instances where characters engage the human-animal boundary, this thesis constructs an argument that highlights the fluidity of the human-animal boundary through examples from the series and analysis of Rowling's characters.ID: 030476283; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Accepted in partial fulfillment of the requirements for honors in the major in English.; Thesis (B.A.)--University of Central Florida, 2011.; Includes bibliographical references (p. 64-71).
B.A.
Bachelors
Arts and Humanities
English
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Broussard, Brittany. "Don't be a fool - play the man! : imperial masculinity in victorian adventure novels." Honors in the Major Thesis, University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1074.
Full textAbstract:
This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.Bachelors
Arts and Humanities
English
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Phillips, Zachary Rockford. "Holocene Postglacial Fluvial Processes and Landforms in Low Relief Landscapes." Diss., North Dakota State University, 2020. https://hdl.handle.net/10365/32036.
Full textAbstract:
Postglacial rivers are part of the relatively young low-relief landscape system left behind by glaciers. Over time, postglacial rivers are susceptible to both minor and major channel planform changes as the Earth and its newly exposed rivers adjust to new isostatic and geomorphic equilibriums. Those planform changes result in topographic features that are well preserved among the largely unaltered landscape and offer opportunities to learn about the processes that create them. This work focuses on those minor and major planform changes and the resulting landforms, with a focus on processes effecting the glaciolacustrine Red River Valley. Here, three studies were conducted, two regarding minor planform changes and one focusing on major planform changes. Studies included in this work regard 1) the spatial distribution of meander cutoffs and meander cutoff relief on the Red River, 2), avulsion timing and length resulting from isostatic tilting and 3) mobile river ice and bank interaction frequency, locations, and erosion in meandering rivers. Results show that rivers develop meander cutoffs that faster in areas where geologic materials are more easily eroded and their relief shows a positive relationship with the rate of river incision. Major channel path changes (avulsions) in the presence of isostatic tilting were found to be most frequent soon after river establishment while rates of isostatic rebound are high enough to outpace channel incision. River ice was found to most frequently interact with the outer banks of channels with long, tight bends and high sinuosity, potentially contributing to the meandering process. From these results it can be interpreted that postglacial rivers were highly dynamic early in their history and have stabilized over time, with most of the changes occurring in areas with more erodible alluvium. Presently, rivers undergo most of their changes during the spring thaw when mobile river ice is impacting the banks, with sinuous river reaches impacted most frequently by mobile river ice.North Dakota Water Recourses Research Institute (ND WRRI) Fellowship Program
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Atit, Kinnari. "Pattern Identification or 3D Visualization? How Best to Learn Topographic Map Comprehension." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/254701.
Full textAbstract:
PsychologyPh.D.
Science, Technology, Engineering, and Mathematics (STEM) experts employ many representations that novices find hard to use because they require a critical STEM skill, interpreting two-dimensional (2D) diagrams that represent three-dimensional (3D) information. The current research focuses on learning to interpret topographic maps. Understanding topographic maps requires knowledge of how to interpret the conventions of contour lines, and skill in visualizing that information in 3D (e.g. shape of the terrain). Novices find both tasks difficult. The present study compared two interventions designed to facilitate understanding for topographic maps to minimal text-only instruction. The 3D Visualization group received instruction using 3D gestures and models to help visualize three topographic forms. The Pattern Identification group received instruction using pointing and tracing gestures to help identify the contour patterns associated with the three topographic forms. The Text-based Instruction group received only written instruction explaining topographic maps. All participants then completed a measure of topographic map use. The Pattern Identification group performed better on the map use measure than participants in the Text-based Instruction group, but no significant difference was found between the 3D Visualization group and the other two groups. These results suggest that learning to identify meaningful contour patterns is an effective strategy for learning how to comprehend topographic maps. Future research should address if learning strategies for how to interpret the information represented on a diagram (e.g. identify patterns in the contour lines), before trying to visualize the information in 3D (e.g. visualize the 3D structure of the terrain), also facilitates students' comprehension of other similar types of diagrams.
Temple University--Theses
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Nishiura, Toru. "The description of the characters in Herman Melville's White-jacket, or the world in a man-of-war." Huntington, WV : [Marshall University Libraries], 2005. http://www.marshall.edu/etd/descript.asp?ref=589.
Full text
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Doerr, Sarah A. "The man and the creation : an inquiry into the modern fascination of king Tutankhamun." Honors in the Major Thesis, University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1075.
Full textAbstract:
This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.Bachelors
Arts and Humanities
Humanities
30
Ficek, Douglas. ""Man Is a Yes": Fanon, Liberation, and the Playful Politics of Philosophical Archaeology." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/216541.
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PhilosophyPh.D.
What is the meaning of Fanonian liberation? That is the question that animates this work, which is (negatively) inspired by the reality of misanthropy, practical and theoretical, and neocolonialism, external and internal. To answer this question, I first situate Frantz Fanon within the larger discourse of liberation, emphasizing the relationship between his liberatory work and the work of Gustavo Gutiérrez, Paulo Freire, and Enrique Dussel. From there, I argue that there is today an unfortunate privileging of ethics, and that this privileging is used to discredit the political as an intersubjective domain. To establish (what I call) the primacy of politics, I carefully analyze Fanon's first book, Black Skin, White Masks, and his sociogenetic conclusions. I then turn to The Wretched of the Earth and to the phenomenon of petrification, which is, I contend, one of the most important features of colonialism and neocolonialism. To fully explain this phenomenon, I consider both its mythopoetic significance and its relationship to Jean-Paul Sartre's conception of seriousness. Finally, I argue that the solution to the problem of petrification can be found in Fanon's second book, A Dying Colonialism, in which there are rich descriptions of political playfulness and (what I call) philosophical archaeology, which can be defined as the descriptive and evaluative analysis of meanings as contingent human artifacts.
Temple University--Theses
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Romero, Claudia. "CELLULAR IMMUNE RESPONSE AND GENE EXPRESSION PROFILING IN CROHN'S DISE." Doctoral diss., University of Central Florida, 2004. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2704.
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Despite the chronic debate in the etiology of crohn's disease (cd), a debilitating inflammatory bowel disease (ibd) closely related to ulcerative colitis (uc), an emerging interest in a possible mycobacterial role has been marked. Granuloma and pathologic manifestations in cd resemble aspects found in tuberculosis, leprosy and paratuberculosis. The latter, a chronic enteritis in cattle, goat, sheep and primates, which is similar to human enteritis, also known as cd, is caused by a fastidious, slow growing mycobacterium avium subspecies paratuberculosis (map). Due to the similarities between cd and paratuberculosis, a mycobacterial cause in cd has been proposed. Recent discovery of a possible association between nod2/card15 mutations and risk of cd added support to microorganism-host interactions. In this study, a possible mycobacterial role in cd etiology has been evaluated by investigating the presence of map dna, the state of the cellular immune response and microarray gene expression profiling in peripheral blood and surgical tissue from cd, uc and healthy control subjects. Nested pcr detected map dna in tissue from 10/12(83%) cd patients compared to 1/6(17%) non-ibd subjects. Fluorescence in situ hybridization (fish) with the aid of confocal scanning laser microscopy (cslm) detected map dna in 8/12(67%) cd subjects compared to 0/6(0%) in non-ibd subjects. The detection of map dna by either technique in tissue from cd subjects is significant compared to non-ibd subjects (p < 0.05). Map dna was also detected in both inflamed and non-inflamed tissue from patients with cd suggesting map infiltration in human tissue. Correlation of possible map presence and the function of polymorphonuclear leukocytes (pmn) and peripheral blood mononuclear cells (pbmc) in 19 cd patients and 12 controls have been evaluated. Pmn phagocytosis of viable fitc-map was suppressed in 13/19(68%) cd patients compared to 0/12(0%) in healthy controls (p<0.05). Pbmc phagocytosis of viable fitc-map was suppressed in 5/19(26%) of cd patients compared to 0/12(0%) of healthy controls (p<0.05). The proliferative response of pbmc with t-cell majority from cd and controls subjects was evaluated against pha, candida albicans, pwm and map ppd. Dysfunctional proliferative response against pha was found in 8/19(42%) cd patients compared to 1/12(8.3%) in controls suggesting possible t-cell anergy. Pbmc from 11 cd subjects reacted normally to pha, 7/11(64%) reacted strongly to map ppd suggesting previous exposure to mycobacteria, and 3/11(27%) did not react with map ppd suggesting lack of pre-exposure to mycobacteria. From the seven mycobacterial pre-exposed samples, 6/7(86%) showed a normal ability to recall antigens by activated macrophages when exposed to c. Albicans, and all 7 samples had a normal pwm response. Finally, microarray-chip technology was employed to identify the expression profile of genes that have a role in the immune response of cd patients. Rna was isolated from fresh buffy coats from 8 healthy controls, 2 cd, and 1 uc patients. Chips with an estimated of 30,000 human genes were hybridized to cdna from these samples. We found that 17% of the total number of genes was differentially expressed. Over 200 genes were involved in the immune response, 7 genes where common to both forms of ibd (uc and cd), and 8 genes were found to be either downregulated in cd and upregulated in uc or viceversa. The ifngr1 gene, which encodes the ligand-binding chain of the ifn-gamma receptor, was found to be downregulated in 2/2(100%) of cd patients, but not in uc patients. It is known that defects in ifngr1 are a cause of atypical mycobacterial infection and bcg infection. Patients suffering from this deficiency have an immunologic defect predisposing them to infection with mycobacteria. This correlates with the proposed theory as map being the causative agent of cd. Furthermore, the results indicate a host susceptibility requirement for the establishment of mycobacterial infection in cd patients. Further characterization of ifngr1 using real-time pcr is underway. Collectively, detection of map dna in the majority of cd tissue and the alteration in pmn and pbmc to respond efficiently to map may be related to the fact that mycobacterial pathogens infect phagocytic cells of susceptible hosts and consequently the immune response is dysregulated. Furthermore, the fact that a gene linked to mycobacterial susceptibility was found to be downregulated in cd patients only, strengthens the mycobacterial etiology of cd. In general, the data suggest a possible role for a bacterial pathogen in cd pathogenesis.Ph.D.
Other
Burnett College of Biomedical Sciences
Biomolecular Sciences: Ph.D.
32
Pascual, Mendoza Christian José. "Diseño de red inalámbrica para una compañía del sector minero." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2021. http://hdl.handle.net/10757/656374.
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La siguiente tesis, es sobre el diseño de la red inalámbrica para una compañía del sector minero, utilizando fórmulas, estándares y buenas prácticas brindadas por diversas entidades internacionales, que nos permiten el mejor diseño posible. En el capítulo 1 se dará aspectos introductorios acerca de la compañía y los objetivos planteados. En el capítulo 2, se da soporte científico y teórico a la tecnología, estándares y especificaciones empleadas. En el capítulo 3, se plantea el problema a resolver, sus causas, consecuencias, requerimientos y posible solución. En el capítulo 4, a nivel técnico, se propone las especificaciones y mejores prácticas en el desarrollo del diseño como es: las frecuencias libres de 2.4 GHz para acceso a la red, 5 GHz para la utilización de mesh y la frecuencia de 60 GHz para los enlaces microondas. En el capítulo 5, se validará el diseño propuesto contra los objetivos específicos propuestos en el capítulo 1. Finalmente, en el capítulo 6 y 7, se da recomendaciones y conclusiones.The following thesis is about the design of the wireless network for one mining company, using formulas, standards and good practices provided by various international entities, which allow us the best possible design. In chapter 1 introductory aspects about the company and its objectives will be given. In Chapter 2, scientific and theoretical support is given to the technology, standards and specifications used. In chapter 3, the problem to be solved, its causes, consequences, requirements and possible solution are presented. In chapter 4, at a technical level, the specifications and best practices in the development of the design are proposed, such as: the free frequencies of 2.4 GHz for network access, 5 GHz for the use of mesh and the frequency of 60 GHz for microwave links. In Chapter 5, the proposed design will be validated against the specific objectives proposed in Chapter 1. Finally, in Chapter 6 and 7, recommendations and conclusions are given.
Tesis
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Anna, Kiran Babu. "A NEW FRAMEWORK FOR QOS PROVISIONING IN WIRELESS LANS USING THE P-PERSISTENT MAC PROTOCOL." Doctoral diss., University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2381.
Full textAbstract:
The support of multimedia traffic over IEEE 802.11 wireless local area networks (WLANs) has recently received considerable attention. This dissertation has proposed a new framework that provides efficient channel access, service differentiation and statistical QoS guarantees in the enhanced distributed channel access (EDCA) protocol of IEEE 802.11e. In the first part of the dissertation, the new framework to provide QoS support in IEEE 802.11e is presented. The framework uses three independent components, namely, a core MAC layer, a scheduler, and an admission control. The core MAC layer concentrates on the channel access mechanism to improve the overall system efficiency. The scheduler provides service differentiation according to the weights assigned to each Access Category (AC). The admission control provides statistical QoS guarantees. The core MAC layer developed in this dissertation employs a P-Persistent based MAC protocol. A weight-based fair scheduler to obtain throughput service differentiation at each node has been used. In wireless LANs (WLANs), the MAC protocol is the main element that determines the efficiency of sharing the limited communication bandwidth of the wireless channel. In the second part of the dissertation, analytical Markov chain models for the P-Persistent 802.11 MAC protocol under unsaturated load conditions with heterogeneous loads are developed. The Markov models provide closed-form formulas for calculating the packet service time, the packet end-to-end delay, and the channel capacity in the unsaturated load conditions. The accuracy of the models has been validated by extensive NS2 simulation tests and the models are shown to give accurate results. In the final part of the dissertation, the admission control mechanism is developed and evaluated. The analytical model for P-Persistent 802.11 is used to develop a measurement-assisted model-based admission control. The proposed admission control mechanism uses delay as an admission criterion. Both distributed and centralized admission control schemes are developed and the performance results show that both schemes perform very efficiently in providing the QoS guarantees. Since the distributed admission scheme control does not have a complete state information of the WLAN, its performance is generally inferior to the centralized admission control scheme. The detailed performance results using the NS2 simulator have demonstrated the effectiveness of the proposed framework. Compared to 802.11e EDCA, the scheduler consistently achieved the desired throughput differentiation and easy tuning. The core MAC layer achieved better delays in terms of channel access, average packet service time and end-to-end delay. It also achieved higher system throughput than EDCA for any given service differentiation ratio. The admission control provided the desired statistical QoS guarantees.Ph.D.
School of Electrical Engineering and Computer Science
Engineering and Computer Science
Computer Science PhD
34
Burney, James L. "Effects of avian breeding colonies on a man-made freshwater marsh in East Central Florida." Master's thesis, University of Central Florida, 1995. http://digital.library.ucf.edu/cdm/ref/collection/RTD/id/24653.
Full textAbstract:
University of Central Florida College of Arts and Sciences ThesisThe effects of nutrient loading from avian breeding colonies into aquatic/marine ecosystems have been well documented. Documented influences include increased productivity of aquatic/marine macrophytes, elevated sediment nutrient concentrations, and increased densities of zooplankton and planktivorus fishes. The primary pathway of nutrient export from the rookery is through excreta from adult birds and thier offspring. This study examined the influences of a 400-nesting pair rookery of cattle egret (Bubulcus ibis) in 1990 and a 75-nesting pari rookery of cattle egret in 1991 on a man-made freshwater treatment marsh in east central Florida. Because the fundamental intent of the created marsh (study site) was the removal of nutrients, primarily nitrogen and phosphorus, from advanced treated wastewater prior to discharge into public surface waters, the main objective of this study was to document the effects of the avian breeding colonies on water quality within the system. Secondary objectives of the study were to document influences on phytoplankton density and aquaitic faunal community structure, as well as to estimate spatial and temporal limits of rookery influences. The results indicated significant water quality differences between rookery and reference sites during 1990 and 1991. The results also indicated significant differences between phytoplankton productivity and aquatic macroinvertebrate community structure between rookery and reference sites during 1990 and 1991. The effects of nutrient loading from the rookeries were confined to within 150 m and background water quality conditions were regained within one month of rookery abandonment. In effect, the 1990 and 1991 rookery sites were characterized as limited, transient "islands" of increased eutrophication within the marsh.
M.S.;
Biological Sciences
Arts and Sciences;
Biological Science;
95 p.
x, 95 leaves, bound : ill. ; 28 cm.
35
Elezovikj, Semir. "FOREGROUND AND SCENE STRUCTURE PRESERVED VISUAL PRIVACY PROTECTION USING DEPTH INFORMATION." Master's thesis, Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/259533.
Full textAbstract:
Computer and Information ScienceM.S.
We propose the use of depth-information to protect privacy in person-aware visual systems while preserving important foreground subjects and scene structures. We aim to preserve the identity of foreground subjects while hiding superfluous details in the background that may contain sensitive information. We achieve this goal by using depth information and relevant human detection mechanisms provided by the Kinect sensor. In particular, for an input color and depth image pair, we first create a sensitivity map which favors background regions (where privacy should be preserved) and low depth-gradient pixels (which often relates a lot to scene structure but little to identity). We then combine this per-pixel sensitivity map with an inhomogeneous image obscuration process for privacy protection. We tested the proposed method using data involving different scenarios including various illumination conditions, various number of subjects, different context, etc. The experiments demonstrate the quality of preserving the identity of humans and edges obtained from the depth information while obscuring privacy intrusive information in the background.
Temple University--Theses
36
Zavala, Ortiz Daniel. "Application of in situ near infra-red spectroscopy (NIRS) for monitoring biopharmaceuticals production by cell cultures." Electronic Thesis or Diss., Université de Lorraine, 2020. http://www.theses.fr/2020LORR0040.
Full textAbstract:
La complexité des médicaments biopharmaceutiques implique que leur validation par les instances réglementaires nécessite un processus spécifique. Tout changement, notamment du procédé, nécessite une nouvelle validation en termes d’efficacité clinique et de sécurité pour le patient. Puisque les changements dans le procédé sont parfois inévitables, la qualité du produit n’a plus à être évaluée uniquement en fin de procédé de production (Quality by testing, QbT), mais tout au long du procédé, et conceptualisée dans toutes les étapes de fabrication (Quality by Design, QbD). Cette démarche préconise de contrôler les paramètres critiques du procédé (CPP) en temps réel afin de maintenir les attributs de qualité critiques (CQA) dans une zone de confiance préalablement définie. Cependant, la mise en œuvre du QbD est actuellement limitée dans l’industrie biopharmaceutique en raison de la complexité des procédés de culture cellulaire ainsi que par la nécessité d’utiliser des méthodes d’analyse multivariée de données issues des analyseurs du procédé (i.e. méthodes spectroscopiques). L’objectif de ce travail a dont été de développer de nouvelles applications méthodologiques et expérimentales, basées sur la spectroscopie proche infrarouge (NIR) in situ, pour le suivi en temps réel de cultures de cellules produisant des biopharmaceutiques. Pour cela, deux modèles cellulaires ont été étudiés : des cellules de hamster chinois (CHO) produisant un anticorps monoclonal (mAb) et des cellules de plantes (Cantharanthus roseus) produisant des molécules anticancéreuses (la vincristine, VC et la vinblastine, VB). Dans un premier temps, un procédé permettant la production de VC et de VB a été développé. La différentiation cellulaire de Catharanthus roseus ayant été identifiée comme un CPP, son suivi en ligne a été rendu possible grâce à l’utilisation combinée de la spectroscopie NIR et de modèles de calibration basés sur la régression des moindres carrés partiels (PLS). Dans un second temps, pour les cultures de cellules CHO, différentes techniques de régressions ont été évaluées pour générer des modèles de calibration permettant le suivi en ligne des CPP et des CQA. La régression PLS s’est révélée inadéquate en raison de la variabilité chimique et physique que les cellules CHO entrainent durant les différentes phases de culture. Au contraire, la régression LWR (Local Weighted Regression) a permis de suivre en temps réel des CPP conventionnels (concentration en glucose, en lactate, en cellules vivantes,…). Cette régression permet de gérer de manière adéquate la variabilité associée à la culture cellulaire. Cependant, pour le suivi du profil de glycosylation des anticorps (CQA), cette régression n’est pas capable de gérer les relations non-linéaires existantes entre les spectres NIR et les concentrations en diverses formes d’anticorps glycosylés. Ce suivi en ligne des différentes glycoformes a été rendu possible uniquement par l’utilisation de la régression SVR (Support Vector Regressions). Ainsi, ce travail a permis l’amélioration du suivi en ligne de CPP par la spectroscopie NIR, mais également le suivi de nouveaux CPP comme l’état physiologique de cellules de plantes ou encore les différentes glycoformes des anticorpsThe complexity of biopharmaceutical products implies that their approval is based on a specific process. Any further change, especially in the process, requires drug validation in terms of clinical effects and biosecurity. Because changes in the processes may be unavoidable, quality assurance by inspection at the end of the process (Quality by Testing-QbT) tends to be replaced by a new quality perspective called Quality by design (QbD) which builds drug Critical Quality Attributes (CQA) controlling key Critical Process Parameters (CPP) in real-time. However, QbD implementation has been limited by the complexity of cell culture processes and the need for multivariate methods that allow the use of complex signals from process analyzers as monitoring instruments. Consequently, the objective of this work has been to develop new methodological and experimental applications, based on in situ NIR spectroscopy, for real-time monitoring of biopharmaceutical-producing cell cultures using two production platforms: animal cells (CHO-250-9) producing monoclonal antibodies (mAb) and plant cells (Cantharanthus roseus) producing antineoplastic molecules (vincristine-VC and vinblastine-VB). First, a process capable of producing VC and VB was generated, cell differentiation was identified as CPP and the ability to monitor it by in situ NIR spectroscopy was firstly demonstrated using calibration models based on partial least squares regression (PLSR). Subsequently in CHO cell cultures, different regression techniques were evaluated to generate calibration models to monitor CPP and CQA. PLSR was inadequate because of the chemical and physical variability that CHO cell cultures present during the different phases of batch culture. Local Weighted Regression (LWR) was adequate to monitor classic CPP (concentration of glucose, lactate, and viable cells, amongst others) since it adequately handled the variability associated with the progression of cell culture. However, for the glycosylation profile (CQA), it was unable to properly handle the complex nonlinear relationships between NIR spectra and the concentration of various monoclonal antibody (mAb) glycoforms. This was overcome with the use of models based on support vector regressions (SVR), allowing the generation of models of different mAb glycoforms related to particular clinical effects. Globally, this work has contributed to the expansion of the capabilities of in situ NIR spectroscopy for the monitoring of classic CPP in a more precise way, new innovative CPP such as cell physiological state in plant suspension cultures, and CQA such as mAb glycosylation profiles linked to clinical characteristics in animal cell cultures
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Chehtane, Mounir. "REAL TIME REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION FOR DIRECT DETECTION OF VIABLE MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS IN CROHN S DISEASE PATIENTS and ASSOCIATION OF MAP INFECTION WITH DOWNREGUALTION IN INTERFERON-GAMMA RECEPTOR (INFG." Master's thesis, University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4281.
Full textAbstract:
Association of Mycobacterium avium subspecies paratuberculosis (MAP) with Crohn's disease (CD) and not with ulcerative colitis (UC), two forms of inflammatory bowel disease (IBD), has been vigorously debated in recent years. This theory has been strengthened by recent culture of MAP from breast milk, intestinal tissue and Blood from patients with active Crohn's disease. Culture of MAP from clinical samples remained challenging due to the fastidious nature of MAP including its lack of cell wall in infected patients. The advent of real time PCR has proven to be significant in infectious disease diagnostics. In this study, real time reverse transcriptase PCR (RT-PCR) assay based on targeting mRNA of the IS900 gene unique to MAP has been developed. All variables included in RNA isolation, cDNA synthesis and real time PCR amplification have been optimized. Oligonucleotide primers were designed to amplify 165 bp specific to MAP and the assay demonstrated sensitivity of 4 genomes per sample. In hope this real time RT-PCR may aid in the detection of viable MAP cells in Crohn's disease patients, a total of 45 clinical samples were analyzed. Portion of each sample was also subjected to 12 weeks culture followed by standard nested PCR analysis. The samples consisted of 17 cultures (originated from 13 CD, 1 UC and 3 NIBD subjects), 24 buffy coat blood (originated from 7 CD, 2 UC, 11 NIBD and 4 healthy subjects) and 4 intestinal biopsies from 2 CD patients. Real time RT-PCR detected viable MAP in 11/17 (65%) of iii suspected cultures compared to 12/17 (70%) by nested PCR including 77% and 84% from CD samples by both methods, respectively. Real time RT-PCR detected MAP RNA directly from 3/7 (42%) CD, 2/2 (100%) UC and 0/4 healthy controls similar to results following long term culture incubation and nested PCR analysis. Interestingly, real time RT-PCR detected viable MAP in 2/11 (13%) compared to 4/11 (26%) by culture and nested PCR in NIBD patients. For tissue samples, real time RT-PCR detected viable MAP in one CD patient with the culture outcome remains pending. This study clearly indicates that a 12-hr real time RT-PCR assay provided data that are similar to those from 12 weeks culture and nested PCR analysis. Consequently, use of real time In our laboratory, we previously demonstrated a possible downregulation in the Interferon-gamma receptor gene (IFNGR1) in patients with active Crohn's disease using microarray chip analysis. In this study, measurement of RNA by real time qRT-PCR indicated a possible downregulation in 5/6 CD patients compared to 0/12 controls. The preliminary data suggest that downregulation in INFGR1 gene, and the detection of viable MAP in CD patients provides yet the strongest evidence toward the linkage between MAP and CD etiology.M.S.
Department of Molecular Biology and Microbiology
Burnett College of Biomedical Sciences
Molecular Biology and Microbiology
38
Medina, Pamela. "A Plurinational State: The Impact of the MAS on the Status of Indigenous People in Bolivia." Master's thesis, University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2395.
Full textAbstract:
In 2005 the largely indigenous country of Bolivia elected its first indigenous president, Evo Morales of the Movement toward Socialism (MAS) Party. Morales ran on a promise of re-distributing wealth, to aid in the development of one of Latin America's poorest countries. Morales' first term in office marked a historical achievement for the indigenous movement in Bolivia, and sparked social change in the country. The government also experienced a momentous achievement through the re-writing of the Bolivian constitution, acknowledging the country's multi-ethnic and pluri-national character. Although his social, domestic and foreign policies have been controversial, particularly in the United States, Morales was re-elected to serve a second term in 2009. This research analyzes the outcomes of Morales' policy changes during his first term in office, from 2006-2009 to examine how the election of the MAS has impacted the marginalized status of indigenous people in Bolivia.M.A.
Department of Political Science
Sciences
Political Science MA
39
Rahman, Mohammed Mizanur. "Application of SWAT for Impact Analysis of Subsurface Drainage on Streamflows in a Snow Dominated Watershed." Thesis, North Dakota State University, 2011. https://hdl.handle.net/10365/29555.
Full textAbstract:
The wet weather pattern since the early 1990's has created two problems for the people living in the Red River Valley (RRV): (1) wet field conditions for farmers and (2) more frequent major spring floods in the Red River system. Farmers in the region are increasingly adopting subsurface drainage practice to remove excess water from their fields to mitigate the first problem. However, it is not clear whether subsurface drainage will deteriorate or mitigate the spring flood situation, the second problem. The Soil and Water Assessment Tool (SWAT) model was applied to evaluate the impacts of tile drainage on the Red River's streamflows. The model was calibrated and validated against monthly streamflows at the watershed scale and against daily tile flows at the field scale. The locations and areas of the existing and potential tile drained (PTD) areas were identified using a GIS based decision tree classification method. The existing and maximum PTD areas were found to be about 0.75 and 17.40% of the basin area, respectively. At the field scale, the range of Nash-Sutcliffe efficiency (NSE) for model calibration and validation was 0.34-0.63. At the watershed scale, the model showed satisfactory performance in simulating monthly streamflows with NSE ranging from 0.69 to 0.99, except that the model under-predicted the highest spring flood peak flows in three years. The results of modeling a 100% tiled experimental field showed that about 30-40% of water yield was produced as tile flow. Surface runoff and soil water content decreased about 34% and 19%, respectively, due to tile drainage. However, the impact of subsurface drainage on evapotranspiration (ET) and water yield was mixed. ET slightly decreased in a wet year and slightly increased in a dry year, while the pattern for water yield was opposite to that of ET. The watershed-scaled modeling results showed that a tiling rate of 0.75-5.70% would not have significant effects on the monthly average streamflows in the Red River at Fargo. For the 17.40% tiling rate, the streamflow in the Red River at Fargo might increase up to 1% in April and about 2% in Fall (September to November), while decreasing up to 5% in the remaining months. This SWAT modeling study helped to better understand the impact of subsurface drainage on the water balance and streamflows in the Red River of the North basin. The findings will also help watershed managers in making decisions for the purpose of managing agricultural drainage development in the RRV and other snow dominated watersheds around the world.
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Dunn, Eric Malcolm. "MAN UP: AN INVESTIGATION INTO THE INTERSECTIONALITY OF MASCULINITY, SEXUALITY, AND ADULT RECREATIONAL SPORT LEAGUES." Master's thesis, Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/314136.
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KinesiologyM.S.
This study examined the relationship between perceptions of masculinity and attitudes towards lesbians and gay men within an athletic context. Demographic information was utilized to ascertain if certain populations of people have more negative sentiments directed at LGBTQ-identifying individuals. The researcher used modified versions of Herek's Attitudes Towards Lesbian and Gay Men Scale (1984), and Snell's Masculinity Behavior Scale (2013). Surveys were distributed online and the researcher used SPSS to analyze the data. The results suggest that there is not a relationship between perceptions of masculinity and attitudes towards lesbians and gay participants in a sport context. League choice, gender, and sexual orientation were found to be statistically significant predictors of one's attitude towards gay men and league choice was found to be a statistically significant predictor of one's attitude towards lesbian women. Age was found to be a statistically significant predictor of one's beliefs about masculinity, with statistical significance within the subscales of Success Dedication and Exaggerated Self-Control and Reliance. Although statistically significant, the results are not surprising and are consistent with past research of similar populations. It is hoped that future research will include qualitative aspects to gain a better understanding of how non-heterosexual sport participants negotiate their sport and LGBTQ identities.
Temple University--Theses
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Thomas, David. "THE ANXIOUS ATLANTIC: WAR, MURDER, AND A “MONSTER OF A MAN” IN REVOLUTIONARY NEW ENGLAND." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/538853.
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HistoryPh.D.
On December 11, 1782 in Wethersfield, Connecticut, a fifty-two year old English immigrant named William Beadle murdered his wife and four children and took his own life. Beadle’s erstwhile friends were aghast. William was no drunk. He was not abusive, foul-tempered, or manifestly unstable. Since arriving in 1772, Beadle had been a respected merchant in Wethersfield good society. Newspapers, pamphlets, and sermons carried the story up and down the coast. Writers quoted from a packet of letters Beadle left at the scene. Those letters disclosed Beadle’s secret allegiance to deism and the fact that the War for Independence had ruined Beadle financially, in his mind because he had acted like a patriot not a profiteer. Authors were especially unnerved with Beadle’s mysterious past. In a widely published pamphlet, Stephen Mix Mitchell, Wethersfield luminary and Beadle’s one-time closest friend, sought answers in Beadle’s youth only to admit that in ten years he had learned almost nothing about the man print dubbed a “monster.” This macabre story of family murder, and the fretful writing that carried the tale up and down the coast, is the heart of my dissertation. A microhistory, the project uses the transatlantic life, death, and print “afterlife” of William Beadle to explore alienation, anonymity, and unease in Britain’s Atlantic empire. The very characteristics that made the Atlantic world a vibrant, dynamic space—migration, commercial expansion, intellectual exchange, and revolutionary politics, to name a few—also made anxiety and failure ubiquitous in that world. Atlantic historians have described a world where white migrants crisscrossed the ocean to improve their lives, merchants created new wealth that eroded the power of landed gentry, and ideas fueled Enlightenment and engendered revolutions. The Atlantic world was indeed such a place. Aside from conquest and slavery, however, Atlantic historians have tended to elide the uglier sides of that early modern Atlantic world. William Beadle crossed the ocean three times and recreated himself in Barbados and New England, but migrations also left him rootless—unknown and perhaps unknowable. Transatlantic commerce brought exotic goods to provincial Connecticut and extended promises of social climbing, but amid imperial turmoil, the same Atlantic economy rapidly left such individuals financially bereft. Innovative ideas like deism crossed oceans in the minds of migrants, but these ideas were not always welcome. Beadle joined the cause of the American Revolution, but amid civil war, it was easy to run afoul of neighboring patriots always on the lookout for Loyalists. Beadle was far from the only person to suffer these anxieties. In the aftermath of the tragedy, commentators strained to make sense of the incident and Beadle’s writings in light of similar Atlantic fears. The story resonated precisely because it raised worries that had long bubbled beneath the surface: the anonymous neighbor from afar, the economic crash out of nowhere, modern ideas that some found exhilarating but others found distressing, and violent conflict between American and English. In his print afterlife, William Beadle became a specter of the Atlantic world. As independence was won, he haunted Americans as well, as commentators worried he was a sign that the American project was doomed to fail.
Temple University--Theses
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Brown, Coote Tracey Antoinette Kay. "Students’ Perception About Their Performance In English At Three Evening Schools In Savanna La Mar." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/561906.
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Educational LeadershipEd.D.
This case study explored students’ perception about their performance in CSEC English A at three evening schools in Savanna La Mar. While conducting the research I used ethnographic methods, including interviews, observations and document analysis to better understand students’ perceptions of their performance in CSEC English A. The central questions which guided the research are “how do students at three evening schools in Savanna La Mar perceive their performance in CSEC English A and what factors affect those perceptions, and what strategies do students think can improve their performance in English?” Creswell’s (2008) steps for analyzing qualitative data were used to explore the central research questions. The discussion sought to highlight how students perceived their academic performance in CSEC English A and what attributed for these perceptions. These views were examined using four themes: student factors that influence student learning outcome, influence of Jamaican Creole (JC) on learning Standard Jamaican English (SJE), teacher traits that influence learning and structure and operations of the evening schools. The Attribution and Expectancy Value Theories were used to make meaning of the data. The findings revealed that most of the students exhibited high self-concept and expressed that they would be successful in the upcoming CSEC English A Examination despite previous challenges they experienced with SJE. They attributed this success to the strategies they were using and the encouragement and positive feedback they got from their teachers. However, some students cited several factors which have negatively affected their performance such as the predominant use of JC in the home, school and community. Although the research was a multiple site study, it was limited to one geographical location which delimited the generalizability of the study. However, the insights gained can contribute to and fill gaps in the literature and also enlighten educators and other stakeholders of students’ perception about their performance in CSEC English A.
Temple University--Theses
43
Wang, Guoqiang. "MAC LAYER AND ROUTING PROTOCOLS FOR WIRELESS AD HOC NETWORKS WITH ASYMMETRIC LINKS AND PERFORMANCE EVALUATION STUDIES." Doctoral diss., University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3402.
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In a heterogeneous mobile ad hoc network (MANET), assorted devices with different computation and communication capabilities co-exist. In this thesis, we consider the case when the nodes of a MANET have various degrees of mobility and range, and the communication links are asymmetric. Many routing protocols for ad hoc networks routinely assume that all communication links are symmetric, if node A can hear node B and node B can also hear node A. Most current MAC layer protocols are unable to exploit the asymmetric links present in a network, thus leading to an inefficient overall bandwidth utilization, or, in the worst case, to lack of connectivity. To exploit the asymmetric links, the protocols must deal with the asymmetry of the path from a source node to a destination node which affects either the delivery of the original packets, or the paths taken by acknowledgments, or both. Furthermore, the problem of hidden nodes requires a more careful analysis in the case of asymmetric links. MAC layer and routing protocols for ad hoc networks with asymmetric links require a rigorous performance analysis. Analytical models are usually unable to provide even approximate solutions to questions such as end-to-end delay, packet loss ratio, throughput, etc. Traditional simulation techniques for large-scale wireless networks require vast amounts of storage and computing cycles rarely available on single computing systems. In our search for an effective solution to study the performance of wireless networks we investigate the time-parallel simulation. Time-parallel simulation has received significant attention in the past. The advantages, as well as, the theoretical and practical limitations of time-parallel simulation have been extensively researched for many applications when the complexity of the models involved severely limits the applicability of analytical studies and is unfeasible with traditional simulation techniques. Our goal is to study the behavior of large systems consisting of possibly thousands of nodes over extended periods of time and obtain results efficiently, and time-parallel simulation enables us to achieve this objective. We conclude that MAC layer and routing protocols capable of using asymmetric links are more complex than traditional ones, but can improve the connectivity, and provide better performance. We are confident that approximate results for various performance metrics of wireless networks obtained using time-parallel simulation are sufficiently accurate and able to provide the necessary insight into the inner workings of the protocols.Ph.D.
School of Electrical Engineering and Computer Science
Engineering and Computer Science
Computer Science PhD
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Cooper, Trevin. "Attention Must Be Paid: A Critical Study of the Non-Traditional Leading Man in Twentieth Century Drama." Master's thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5617.
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The role of the non-traditional leading man has painted a strong image which mirrors the cultural development of our identities; we turn to these men/characters to understand who, or why, we are. Their contributions require acknowledgement. This thesis is a study of the vital role the non-traditional leading man has played in the evolution of twentieth-century theatre. It will examine, through the use of ten plays, one from every decade of the twentieth century, and twelve male roles, the theory that some of the greatest leading male characters in modern theatre are not epitomized by the qualities identified with the stereotypical, romantic leading man, but instead by characters who serve as a representative of the evolution of man, and his ever-changing role in history.M.F.A.
Masters
Theatre
Arts and Humanities
Theatre; Acting
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Dandrow, Edward Michael. "Man, God and state : a re-vision of the medieval vice in late medieval and renaissance drama." Honors in the Major Thesis, University of Central Florida, 1992. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/64.
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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.Bachelors
Arts and Sciences
English
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Umelo, Elizabeth Rhoda Osondu. "The physical and genetic map of the A. salmonicida A449 chromosome, molecular characterization of reca and a novel fla operon." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34288.pdf.
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Esposito, Robert Anthony. "TURBO CODING IMPLEMENTED IN A FINE GRAINED PROGRAMABLE GATE ARRAY ARCHITECTURE." Diss., Temple University Libraries, 2009. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/26071.
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EngineeringPh.D.
One recent method to approach the capacity of a channel is Turbo Coding. However, a major concern with the implementation of a Turbo Code is the overall complexity and real-time throughput of the digital hardware system. The salient design problem of Turbo Coding is the iterative decoder, which must perform calculations over all possible states of the trellis. Complex computations such as exponentiations, logarithms and division are explored as part of this research to compare the complexity of the traditionally avoided maximum a-posteriori probability (MAP) decoder to that of the more widely accepted and simplified Logarithm based MAP decoder (LOG-MAP). This research considers the fine grained implementation and processing of MAP, LOG-MAP and a hybrid LOG-MAP-Log Likelihood Ratio (LLR) based Turbo Codes on a Xilinx Virtex 4 PGA. Verification of the Turbo Coding system performance is demonstrated on a Xilinx Virtex 4 ML402SX evaluation board with the EDA of the Xilinx System Generator utilizing hardware co-simulation. System throughput and bit error rate (BER) are the performance metrics that are evaluated as part of this research. An efficient system throughput is predicated by the parallel design of the decoder and BER is determined by data frame size, data word length and the number of decoding iterations. Furthermore, traditional and innovative stopping rules are evaluated as part of this research to facilitate the number of iterations required during decoding.
Temple University--Theses
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Rosenbloom, Rebecca Elyse. "AURAL SUBSTANCE: AN ETHNOGRAPHIC EXPLORATION OF REGIONAL BURN SOUNDSCAPES." Master's thesis, Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/452764.
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Music HistoryM.M.
Once a year over the week leading up to and including Labor Day, tens of thousands of people drive hours into Nevada’s barren Black Rock Desert to build an ephemeral city equal to “the size of downtown San Francisco.” This place, Black Rock City, home of the annual Burning Man event, only exists for a fraction of the year. For one week, participants gather together at Burning Man and operate under its ten guiding principles, including “radical self-reliance,” “communal effort,” “radical self-expression,” and “participation.” Everything, with the exception of porta-potties and ice, must be brought in and packed out by individuals. The decommodified, volunteer-run city is what its inhabitants make of it. At Burning Man, attendants are their own event planners, food providers, structure builders, gift givers, and activity coordinators. On the penultimate night of the event, an effigy of a forty-foot man is set aflame, a ritual left open for interpretation by participants. Two days later, the entirety of Black Rock City is torn down, leaving scarcely any trace that it ever even existed. Burning Man has gained social traction exponentially since its launch in 1986, leading to the formation of dozens of individually organized regional burns across the United States of America and internationally. Scholars from many disciplines have flocked to the event attempting to unpack its distinct subculture. While publications have analyzed Burning Man’s ethos, logistics, business organization, community, art, rituals, fire, and performances, only two have considered sound worthy of focus and few have addressed the regional burn network. “Aural Substance: An Ethnographic Exploration of Regional Burn Soundscapes” analyzes Burning Man’s regional network, expanding on sound artists Stephan Moore and Scott Smallwood’s brief initial study of the national event's sound by way of ethnography and field recording. From June 2016 through February 2017, I conducted fieldwork and collected fifty-five hours of field recordings at seven different regional burns. I employ ethnomusicologist Steven Feld’s concept of “acoustemology,” or “sound as a way of knowing.” Through my observation, analysis of recordings, and interviews, I consider how the sounds at regional burns can signify the time, date, and location to burn participants. Sound-studies scholar David Novak writes that “noise is a crucial element of communicational and cultural networks.” In this study, I analyze how noise at a burn is not solely a by-product of participants’ “anarchistic freedom,” but a key part of the burn that relays information about regional burn values, public and private spaces, and burners’ lived experience.
Temple University--Theses
49
Rosenbloom, Rebecca Elyse. "Archive.zip." Master's thesis, Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/452765.
Full textAbstract:
Music HistoryM.M.
Once a year over the week leading up to and including Labor Day, tens of thousands of people drive hours into Nevada’s barren Black Rock Desert to build an ephemeral city equal to “the size of downtown San Francisco.” This place, Black Rock City, home of the annual Burning Man event, only exists for a fraction of the year. For one week, participants gather together at Burning Man and operate under its ten guiding principles, including “radical self-reliance,” “communal effort,” “radical self-expression,” and “participation.” Everything, with the exception of porta-potties and ice, must be brought in and packed out by individuals. The decommodified, volunteer-run city is what its inhabitants make of it. At Burning Man, attendants are their own event planners, food providers, structure builders, gift givers, and activity coordinators. On the penultimate night of the event, an effigy of a forty-foot man is set aflame, a ritual left open for interpretation by participants. Two days later, the entirety of Black Rock City is torn down, leaving scarcely any trace that it ever even existed. Burning Man has gained social traction exponentially since its launch in 1986, leading to the formation of dozens of individually organized regional burns across the United States of America and internationally. Scholars from many disciplines have flocked to the event attempting to unpack its distinct subculture. While publications have analyzed Burning Man’s ethos, logistics, business organization, community, art, rituals, fire, and performances, only two have considered sound worthy of focus and few have addressed the regional burn network. “Aural Substance: An Ethnographic Exploration of Regional Burn Soundscapes” analyzes Burning Man’s regional network, expanding on sound artists Stephan Moore and Scott Smallwood’s brief initial study of the national event's sound by way of ethnography and field recording. From June 2016 through February 2017, I conducted fieldwork and collected fifty-five hours of field recordings at seven different regional burns. I employ ethnomusicologist Steven Feld’s concept of “acoustemology,” or “sound as a way of knowing.” Through my observation, analysis of recordings, and interviews, I consider how the sounds at regional burns can signify the time, date, and location to burn participants. Sound-studies scholar David Novak writes that “noise is a crucial element of communicational and cultural networks.” In this study, I analyze how noise at a burn is not solely a by-product of participants’ “anarchistic freedom,” but a key part of the burn that relays information about regional burn values, public and private spaces, and burners’ lived experience.
Temple University--Theses
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Nutters, Daniel. "HENRY JAMES AND ROMANTIC REVISIONISM: THE QUEST FOR THE MAN OF IMAGINATION IN THE LATE WORK." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/440381.
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EnglishPh.D.
This study situates the late work of Henry James in the tradition of Romantic revisionism. In addition, it surveys the history of James criticism alongside the academic critique of Romantic-aesthetic ideology. I read The American Scene, the New York Edition Prefaces, and other late writings as a single text in which we see James refashion an identity by transforming the divisions or splits in the modern subject into the enabling condition for renewed creativity. In contrast to the Modernist myth of Henry James the master reproached by recent scholarship, I offer a new critical fiction – what James calls the man of imagination – that models a form of selfhood which views our ironic and belated condition as a fecund limitation. The Jamesian man of imagination encourages the continual (but never resolvable) quest for a coherent creative identity by demonstrating how our need to sacrifice elements of life (e.g. desires and aspirations) when we confront tyrannical circumstances can become a prerequisite for pursuing an unreachable ideal. This study draws on the work of post-war Romantic revisionist scholarship (e.g. Northrop Frye, Frank Kermode, Harold Bloom, Geoffrey Hartman, and Paul de Man) as well as French theory (e.g. Maurice Blanchot, Michel Foucault, and Jacques Derrida) and other traditions (e.g. Kenneth Burke, R.P. Blackmur, and Lionel Trilling) to challenge new instrumentalizing scholarly methodologies that aim to overcome the ironies of critical vision. I argue that James’s man of imagination not only presents a critical agency that profits from criticism’s penchant for ironic repetition but also a politics that can help us navigate the tension between artistic self-stylization and the social constraints intrinsic to the liberal rule of law.
Temple University--Theses