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1

Ng, Shu Rui. "Electrochemical biosensors for real-time detection of angiogenesis." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/25625.

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Electrochemical biosensors have been made to detect the metabolic markers, pH, O2 and glucose, and nitric oxide (NO), the signalling molecule involved in angiogenesis. A novel three-dimensional (3-D) graphene/ionic liquid (IL) nanocomposite demonstrates highly sensitive detection of NO in phosphate buffered saline (PBS). An arginine-glycine-aspartic acid (RGD) peptide-functionalised biomimetic graphene film has been used as both a cell culture and sensing matrix to detect NO released by human umbilical vein endothelial cells (HUVECs) in real-time under acetylcholine (Ach) stimulation. The amou
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Phairatana, Tonghathai. "Bioengineering of novel carbon-based biosensors for real-time biomedical use." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/58345.

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The aim of this thesis was to develop novel carbon-based biosensors and sensors for real-time metabolite and drug detection, to provide the next generation of medical devices which can give clinicians relevant chemical information in real-time at the patient bedside. An autocalibration system was developed using LabSmith programmable components to give precise fluid delivery and excellent temporal control of multiple liquid streams. This enables a 5-point calibration to be carried out using two solutions in 12 minutes. Systems using chitosan, poly(ethylene glycol)diglycidyl ether hydrogel, ele
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Liu, Chang. "Localized Surface Plasmon Resonance Biosensors for Real-Time Biomolecular Binding Study." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/837.

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Surface Plasmon Resonance (SPR) and localized surface plasmon resonance (LSPR) biosensors have brought a revolutionary change to in vitro study of biological and biochemical processes due to its ability to measure extremely small changes in surface refractive index (RI), binding equilibrium and kinetics. Strategies based on LSPR have been employed to enhance the sensitivity for a variety of applications, such as diagnosis of diseases, environmental analysis, food safety, and chemical threat detection. In LSPR spectroscopy, absorption and scattering of light are greatly enhanced at frequencies
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Stengel, Gudrun. "Real time monitoring of DNA hybridization and replication using optical and acoustic biosensors." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971304572.

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5

Hong, Soonjin Barbee Kenneth A. "Quantitative analysis of cell-surface interactions and cell adhesion process in real-time /." Philadelphia, Pa. : Drexel University, 2008. http://hdl.handle.net/1860/2840.

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6

Canelle, Quentin. "Real Time Surface Plasmon Resonance Biosensors, a Powerful Technology to Assess Polyclonal Antibody Avidity." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/216754.

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The present research focused on the development of a new methodology to assess the strength of the interaction between vaccine antigens and elicited polyclonal antibodies through SPR biosensors. Quantifying the binding strength of polyclonal antibodies is of first importance to evaluate the quality of the vaccine as well as to increase the scientific knowledge of immune protection mechanisms. To now the development of such tool has been complicated by the non-specific binding caused by high protein abundance in the blood and serum samples but also by the way of interpreting the data resulting
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Zelada, Guillén Gustavo Adolfo. "Ultrasensitive detection of pathogens in real-time. Potentiometric biosensors based on single-walled carbon nanotubes and aptamers." Doctoral thesis, Universitat Rovira i Virgili, 2011. http://hdl.handle.net/10803/51768.

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Un gran nombre de plataformes de detecció biològica han incorporat materials nanoestructurats com una estratègia per a millorar diversos paràmetres operacionals i de qualitat tals com reduir els temps d'anàlisis i els límits de detecció. Les tècniques electroquímiques de detecció es prefereixen sobre altres tècniques ja que presenten una sèrie d'avantatges com a rapidesa, facilitat de maneig, cost reduït i la reduïda mida dels detectors comercials. Entre les tècniques electroquímiques, les metodologies més simples, comunes i més fàcils de transportar són aquelles basades en la potenciome
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Teerapanich, Pattamon. "Fluorescence-based nanofluidic biosensor platform for real-time measurement of protein binding kinetics." Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30239/document.

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L'analyse cinétique d'interactions de protéines offre une multitude d'informations sur les fonctions physiologiques de ces molécules au sein de l'activité cellulaire, et peut donc contribuer à l'amélioration des diagnostics médicaux ainsi qu'à la découverte de nouveaux traitements thérapeutiques. La résonance plasmonique de surface (SPR) est la technique de biodétection optique de référence pour les études cinétiques d'interaction de molécules biologiques. Si la SPR offre une détection en temps réel et sans marquage, elle nécessite en revanche des équipements coûteux et sophistiqués ainsi que
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9

Brawner, Keith. "Modeling Learner Mood in Realtime through Biosensors for Intelligent Tutoring Improvements." Doctoral diss., University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5774.

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Computer-based instructors, just like their human counterparts, should monitor the emotional and cognitive states of their students in order to adapt instructional technique. Doing so requires a model of student state to be available at run time, but this has historically been difficult. Because people are different, generalized models have not been able to be validated. As a person's cognitive and affective state vary over time of day and seasonally, individualized models have had differing difficulties. The simultaneous creation and execution of an individualized model, in real time, rep
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10

Shah, Niksha Chimanlal Meghji. "Construction and development of bioluminescent Pseudomonas aeruginosa strains : application in biosensors for preservative efficacy testing." Thesis, University of Hertfordshire, 2014. http://hdl.handle.net/2299/15592.

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Whole cell biosensors have been extensively used for monitoring toxicity and contamination of compounds in environmental biology and microbial ecology. However, their application in the pharmaceutical and cosmetics industries for preservative efficacy testing (PET) has been limited. According to several pharmacopoeias, preservatives should be tested for microbial activity using traditional viable count techniques; the use of whole cell microbial biosensors potentially provides an alternative, fast, and efficient method. The aim of the study was to construct and develop whole cell microbial bio
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11

Gowers, Sally. "Microfluidic biosensor systems for real-time in vivo clinical bioanalysis." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/51467.

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The aim of this thesis was to develop online biosensing systems for dialysate tissue metabo- lite detection in real time, to provide an insight into the health of tissue in various in vivo applications. An autocalibration system was developed using LabSmith programmable components to improve the accuracy of results obtained over long monitoring times. A method of col- lecting dialysate into storage tubes for online analysis while retaining temporal resolution was developed and validated. Microfluidic biosensor systems were developed for online measurement of glucose and lactate. One approach e
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Hondroulis, Evangelia. "Real-time Biosensor for the Assessment of Nanotoxicity and Cancer Electrotherapy." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/972.

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Knowledge of cell electronics has led to their integration to medicine either by physically interfacing electronic devices with biological systems or by using electronics for both detection and characterization of biological materials. In this dissertation, an electrical impedance sensor (EIS) was used to measure the electrode surface impedance changes from cell samples of human and environmental toxicity of nanoscale materials in 2D and 3D cell culture models. The impedimetric response of human lung fibroblasts and rainbow trout gill epithelial cells when exposed to various nanomaterials was
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13

Nguyen, Camha. "A tripartile biosensor for real-time SNSs detection in DNA hairpin motif." Honors in the Major Thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/485.

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The hybridization between two complementary strands of nucleic acid is the basis for a number of applications in DNA and RNA analysis, including in vivo RNA monitoring, microarrays, SNPs detection, and so on. The short oligonucleotide probes form Watson/Crick base pairs (A-T and G-C) with the analyzed nucleic acid. Molecular beacon (MB) probe is one of the most advantageous tools for nucleic acid analysis in real-time. A traditional MB probe consists of a DNA strand folded in hairpin motif with a fluorophore attached to the 5'end and a quencher attached to the 3' end. The loop segment is compl
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Binder, Michael. "Development of a Botrytis specific immunosensor : towards using PCR species identification." Thesis, Cranfield University, 2014. http://dspace.lib.cranfield.ac.uk/handle/1826/12110.

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Botrytis species affect over 300 host plants in all climate areas of the world, at both pre and post-harvest stages, leading to significant losses in agricultural produce. Therefore, the development of a rapid, sensitive and reliable method to assess the pathogen load of infected crops can help to prescribe an effective curing regime. Growers would then have the ability to predict and manage the full storage potential of their crops and thus provide an effective disease control and reduce post-harvest losses. A highly sensitive electrochemical immunosensor based on a screen-printed gold electr
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Bouguelia, Sihem. "Développement de biopuces dédiées à la détection de bactéries pathogènes à faibles taux." Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00872457.

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Détection et quantification de bactéries à faible taux par SPRi Résumé: Le protocole standard pour le diagnostic des bactéries dans le domaine médical et agro-alimentaire reste la culture microbienne, qui prend plusieurs jours pour identifier l'agent pathogène. Cependant, ces temps de latence ne sont pas compatibles avec l'urgence d'analyser rapidement la présence de bactéries pathogènes. Il ya un besoin croissant de vouloir développer de nouveaux outils pour identifier les bactéries pathogènes en un temps plus court. Afin atteindre cet objectif, la technologie de l'imagerie par Résonance des
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Choong, Melissa Yen Ying. "Escherichia coli ATCC 8739 biosensor for preservative efficacy testing." Thesis, University of Hertfordshire, 2014. http://hdl.handle.net/2299/15623.

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The preservative challenge test is a regulatory requirement specified in various pharmacopoeias to determine the efficacy of preservatives. However, such testing is a labour-intensive repetitive task and often requires days before results can be generated. Microbial biosensors have the potential to provide a rapid and automated alternative to the traditional viable counting currently in use. However, the selection of appropriate promoters is essential. The bioluminescent reporter strains used in the current study comprise the Photorhabdus luminescence lux CDABE reporter genes under the control
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17

Elsom, Jacqueline. "Development of a quartz crystal based biosensor for real-time monitoring of particulate cell interactions." Thesis, University of Brighton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412096.

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18

Rawson, Frankie James. "The design, development and application of a novel electrochemical biosensor/sensor system for the real-time monitoring of in-vitro cell toxicity." Thesis, University of the West of England, Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557140.

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In recent years there has been a reported requirement by the pharmaceutical and agrochemical industry that there is a need to monitor In vitro cell toxicity in real time, and also a necessity for using cell models that mimic the In vivo situation more closely. The aim of this project was to provide a solution for these key issues set out above. This was achieved by developing, characterising and implementing the use of electrochemical micro-biosensors and micro-sensors manufactured from screen printed electrodes. These were then used for monitoring cytotoxicity in HepG2 spheroids which mimic m
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19

Bracewell, Daniel Gilbert. "The use of an optical biosensor for the real-time monitoring of product and product variants in biological process streams and applications for control." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314156.

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20

Qi, Ziming. "Real-time adaptive noise cancellation for automatic speech recognition in a car environment : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Computer Engineering at Massey University, School of Engineering and Advanced Technology, Auckland, New Zealand." Massey University, 2008. http://hdl.handle.net/10179/812.

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This research is mainly concerned with a robust method for improving the performance of a real-time speech enhancement and noise cancellation for Automatic Speech Recognition (ASR) in a real-time environment. Therefore, the thesis titled, “Real-time adaptive beamformer for Automatic speech Recognition in a car environment” presents an application technique of a beamforming method and Automatic Speech Recognition (ASR) method. In this thesis, a novel solution is presented to the question as below, namely: How can the driver’s voice control the car using ASR? The solution in this thesis is an AS
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21

Li, Chung-Yu, and 李昌昱. "Fabrication of ARROW-B SPR Biosensors and Using the Biosensors for Real-Time Detection of Proteinase Activity." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/84173429325374892270.

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碩士<br>國立交通大學<br>電子工程系所<br>98<br>In this thesis, the fabrication process of ARROW-B SPR sensors used in aqueous environment has been investigated. The sensors are used for real-time detection of proteinase activity. ARROW-B waveguide with a thick guiding region provides efficient coupling with a single-mode fiber. The waveguides in front and rear of the SPR sensing region have symmetric cladding structure to improve the immunity against environmental changes, and the sensing region is configured with a liquid flow channel which enables biomolecules to adhere to the Au surface. Then we apply the
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Chang, Su-Wei, and 張書維. "Fabrication of ARROW-B SPR Biosensors and Using the Biosensors for Real-Time Detection of Immunoassay and Proteinase Activity." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/59823923732929727781.

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碩士<br>國立交通大學<br>電子研究所<br>100<br>In this study, a Si-based ARROW-B SPR biosensor used in aqueous environment has been investigated. The ARROW-B SPR biosensor was proposed to provide a label-free, real-time detection, and highly surface-sensitive platform to detect the bimolecular interactions. Modal characteristics of ARROW-B were analyzed with simulation and the devices were designed for obtaining optimum sensitivity in aqueous environment. The ARROW-B waveguide with a thick guiding region provides efficient coupling with a single-mode fiber. The waveguide in the front and the rear of the SPR
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Tsai, Chen-Yu, and 蔡承鈺. "Fabrication of ARROW-B SPR Biosensors and Its Application to Real-Time Immunoassay." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/20747102193370048293.

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碩士<br>國立交通大學<br>電子工程系所<br>96<br>In this thesis, an ARROW-B SPR sensor used in aqueous environment has been investigated. ARROW-B waveguide with a thick guiding region provides efficient coupling with a single-mode fiber, and the propagation behavior can be modulated by adjusting the structure. Modal characteristics of ARROW-B are analyzed with simulation and designed for obtaining optimum sensitivity in aqueous environment. The waveguides in front and rear of the SPR sensing region have symmetric cladding structure to improve the immunity against environmental changes, and the sensing region i
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Lin, Zheng-Wen, and 林政文. "Fabrication of ARROW-B SPR Biosensors for Real-Time Detection of Protein Kinase A Activity." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/24373859375112653168.

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碩士<br>國立交通大學<br>電子研究所<br>100<br>In this study, surface plasmon resonance (SPR) biosensors with antiresonant reflecting optical waveguide of type B (ARROW-B) structure have been investigated. The ARROW-B SPR biosensors was proposed to provide label-free, high-throughput, and highly sensitivity characteristics to detect the biomolecular interaction for the aqueous environment in real time. Moreover, The ARROW-B waveguide with a thick guiding region provides efficient coupling with a single-mode fiber. Modal characteristics of ARROW-B are analyzed with simulation and designed for obtaining optimu
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Stengel, Gudrun [Verfasser]. "Real time monitoring of DNA hybridization and replication using optical and acoustic biosensors / vorgelegt von Gudrun Stengel." 2004. http://d-nb.info/971304572/34.

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Huang, Chi-Chieh, та 黃繼傑. "Real-Time Detection of α-Thrombin Binding to Single-Strand DNA Aptamers and Dengue Virus DNA Hybridization by ARROW-B SPR Biosensors". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/73575633967046751075.

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碩士<br>國立交通大學<br>電子工程系所<br>96<br>In this thesis, an antiresonant reflecting optical waveguide of type B (ARROW-B) surface plasmon resonance (SPR) biosensor operating in the aqueous environment has been investigated. The ARROW-B SPR biosensor is proposed to provide a label-free, high-throughput and highly surface-sensitive platform to detect the bimolecular interactions in real time. The design and fabrication process of the ARROW-B SPR sensor chips are described and discussed. Besides, the primary analytes for the bioassay experiments are divided into two categories based on different binding c
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Gao, Shiuan-Huei, and 高炫揮. "Label-free and real-time protein biosensor." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/70401169843752291048.

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Liu, Wen-Hsing, and 劉紋杏. "Label-free and real-time electrical biosensor." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/97539236198040691241.

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Yu, Chih-Jen, and 游智仁. "Fiber Optic Biosensor For Real Time Monitoring Protein Binding Kinetics." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/45312132106992113590.

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碩士<br>國立陽明大學<br>生醫光電工程研究所<br>92<br>In cell biological research, protein control mediates many of biological activities of cells. Most of proteins function in association with other protein to gain an cellular function. Therefore protein-protein interaction becomes essential to understand biological activities that have been studied by determination of kinetic constants. The fiber optic biosensor is one of the easiest way to setup to study the kinetics of protein-protein interaction in real time where the optical fiber is disposable in the measurement. Then fiber optic biosensor is a novel equi
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Yu, Yuh-Yan, and 游育諺. "Use of Piezoresistive Microcantilever Biosensor to Real-Time Monitor Bio-molecules." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/98595062607123148030.

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碩士<br>國立臺灣大學<br>應用力學研究所<br>94<br>Bio-sensing tools have been moving towards miniaturization, high sensitivity, portability and wireless networking. While fluorescent labeling of nucleic acids is becoming a standard procedure, protein labeling techniques are not yet as well established. The purpose of this paper is to demonstrate a novel reusable biosensor which achieves the continuous label-free recognition of biological substances in real-time, which based on the nanomechanics of a piezoresistive microcantilever. Over the past few years, an increasingly evident number of studies have been con
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Lin, Chih-Chang, and 林志昌. "Real-time detection of Nitric Oxide and Label-free protein biosensor." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/71964322661497231035.

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碩士<br>國立交通大學<br>電子物理系所<br>97<br>In the past, it is complex and expensive to detect NO and protein. This work develops a real-time and label-free biosensor for nitric oxide (NO) and protein. Two sections will be included: The first section describes a real-time NO electrical sensor. In2O3 is functionalized with 3,4-Diaminobenzoic acid as chemical probe for detecting NO. S-Nitroso-N-acetylpenicillamine is used as NO donor. The readout current from a two-terminal In2O3 device varies with NO in the environment. The second section describes a real-time and label-free protein optical sensor. Por
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Chen, Wei-Chuan, and 陳韋全. "Signal Acquisition and Analysis of Real-Time Monitor System of Miniaturized Biosensor." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/02041222711504146301.

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碩士<br>國立雲林科技大學<br>光學電子工程研究所<br>97<br>The sensor is a kind of device about electrochemical science, and its applications include clinical and environmental analyses, physiology, process control, etc. Therefore, how to accurately detect the sensor signal is one of the most important procedures for relative applications. In this study, a multi-electrode measurement system was prepared for potentiametric sensor to proceed with dynamic measurement and real-time display. This system will be classified with two parts, which are the fabrication of electrode and embodiment of the measurement system. Ho
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Jou, Li-John, and 周立強. "Asiatic clam (Corbicula fluminea)–based dynamic biosensor for real-time in situ monitoring waterborne metals." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/54804785186442630757.

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博士<br>國立臺灣大學<br>生物環境系統工程學研究所<br>95<br>The goal of this dissertation is to develop a novel freshwater clam Corbicula fluminea-based on-line bimonitoring system as a bioassay tool to offer a real-time and cost-effective method to measure copper (Cu) and cadminm (Cd) concentrations in natural water resources. The proposed system used sublethal changes in the daily valve closing activites of C. fluminea as a biological endpoint and built upon the basic principles of biological early warning system (BEWS) model in three phases. In the first phase, a probabilistic-based approach describing the valve
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Tsai, Hsiao-chung, and 蔡曉忠. "Optimization of Acetylcholinesterase based on Fiber-Optic Biosensor for Real-Time Monitoring of Organophosphorus Pesticides." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/02492711709550683843.

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碩士<br>國立清華大學<br>原子科學系<br>87<br>Organophosphorus pesticides (OPPs) are widely used as insecticides for agricultural or household purposes since 1970s. Although they can be quickly decomposed in the environment, their highly acute toxicity to acetylcholinesterase (AChE) received highly attention. Therefore, the development of high efficient analytical techniques for real-time monitoring the residues of OPPs in the environments is needed. The purpose of this study is to apply the sol-gel immobilization technology for developing a fiber-optic biosensor using AChE as biological recogni
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Jou, Li-John. "Asiatic clam (Corbicula fluminea)-based dynamic biosensor for real-time in situ monitoring waterborne metals." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2107200704540800.

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Alom, Azharul, and Azharul Alom. "Real-time detection of viruses by portable surface plasmon resonance biosensor with multi-metallic sensor chip." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/31630349587230457534.

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夏德玲. "Real-Time and Label-Free Detection of the Biomolecules with a Novel Side-Gated SiNW-FET Biosensor." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/51525371737386377340.

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碩士<br>國立交通大學<br>奈米科技研究所<br>96<br>It is an important and developing capable issue to combine the semiconductor sensor devices with biomolecules for the future application of disease diagnosis. In the present work, the BRAFV599E mutation gene and cancer marker α-fetoprotein, which have been recently reported to restrict to the papillary thyroid carcinomas (PTCs) and liver cancer, respectively, were chosen as the target biomolecules. The devices based on semiconductor nanowires exhibit high sensitive and selective characteristics for the real-time, label-free, and excellent specificity detection
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Nandakumar, Vijay. "Real-time monitoring and quantification of drug induced changes in endothelial cytoskeleton filaments using a cellular impedance biosensor." 2005. http://etd.utk.edu/2005/NandakumarVijay.pdf.

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Thesis (M.S.) -- University of Tennessee, Knoxville, 2005.<br>Title from title page screen (viewed on Oct. 11, 2005). Thesis advisor: Anthony English. Document formatted into pages (xii, 124 p. : ill. (some col.)). Vita. Includes bibliographical references (p. 70-74).
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Lai, Wen-Tsan, and 賴文燦. "Poly crystalline silicon nanowire field effect transistor based biosensor for highly sensitive, label-free and real-time detection of enterovirus DNA." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/92173365812167395162.

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碩士<br>國立交通大學<br>生物科技學系<br>98<br>Enterovirus 71 (EV 71) is an important pathogen that causes higher morbidity and mortality in children around the world than those of other non-Polio enteroviruses. Its infection is neurotropic and even followed by rapid deterioration within average 3 days. The standard clinical methods for EV 71 identification require virus isolation in cell culture and reverse transcriptase polymerase chain reactions (RT-PCR). Virus isolation requires 5-10 days and hinders the subsequent treatment and disease control. Poly silicon nanowire field effect transistor has been show
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Chen, Jie-Ting, and 陳玠廷. "Design and Analysis of Flexible Screen-Printed Arrayed Glucose Biosensor Based on Multifunction Real-Time Remote Home Care in Wireless Sensing System." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/62050474617467732601.

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碩士<br>國立雲林科技大學<br>電子與光電工程研究所碩士班<br>102<br>In this thesis, the wireless sensor network (WSN) with Zigbee technique is integrated with the glucose biosensor. The wireless sensing system is accomplished by the graphical language laboratory virtual instrumentation engineering workbench (LabVIEW). The wireless sensing system can be classified into two parts, which are the glucose detection system of front end and transmission platform of back end. The glucose detection system embraces ruthenium dioxide polyethylene terephthalate (RuO2/PET) biosensor, silver/silver chloride (Ag/AgCl) reference elect
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Huang, Yu-Wen, and 黃郁雯. "Real-Time and Label-Free Detection of the Prostate-Specific Antigen in Human Serum by a Novel Poly-silicon Nanowire-FET Biosensor." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/22348857927525452434.

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碩士<br>國立交通大學<br>材料科學與工程學系奈米科技碩博士班<br>100<br>The application for disease diagnosis and recurrence prevention of high-sensitive field-effect transistor devices in detecting the biomolecules is a novel and developing technology. In this research, we used poly-silicon nanowire field-effect transistor (poly-Si NWFET) as biosensor which was fabricated by employing the sidewall spacer technique instead of expensive E-beam lithography method. The sidewall spacer technique has the advantages of simplicity and low-cost, comparing to the current commercial semiconductor process. By using these novel devi
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YAN, SIAO-JIE, and 嚴孝傑. "The Analysis of the Stability, Interference, and Impedance for Magnetic Beads and Graphene Modified in Arrayed Flexible Nickel Oxide Glucose and Lactate Biosensor Based on Microfluidic Framework and the Measurement of Real-Time Sensing System." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/694838.

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碩士<br>國立雲林科技大學<br>電子工程系<br>105<br>In this thesis, nickel oxide (NiO) was applied to a flexible arrayed pH sensor, and its sensitivity could be enhanced by changing oxygen content of sputtering gas. The optimal NiO film was applied to a flexible arrayed lactate biosensor and a flexible arrayed glucose biosensor. After that, lactate dehydrogenase (LDH) and glucose oxidase (GOD) were immobilized on the NiO film of above structure to fabricate the flexible arrayed lactate biosensor and flexible arrayed glucose biosensor, respectively. We used graphene oxide (GO) and magnetic beads (MBs) to modify
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CHEN, JIAN-SYUN, and 陳建勳. "The Research of Integrating the Differential Reference Electrode as well as Magnetic Beads and Graphene Modified in Arrayed Flexible IGZO Glucose Biosensor Based on Microfluidic Framework and the Fabrication of Multifunctional Enzyme Real-Time Sensing System." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/wke9x5.

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碩士<br>國立雲林科技大學<br>電子工程系<br>104<br>In this thesis, it was mentioned the enzymatic glucose biosensor was manufactured by using radio frequency sputtering system, thermal evaporation system and screen-printed technology, whose glucose sensing membrane was composed of indium gallium zinc oxide (IGZO) membrane and glucose oxidase (GOx). For enhancing sensing characteristics of enzymatic glucose biosensor, the sensing membrane was modified by graphene oxide (GO) and magnetic beads (MBs) to improve adsorption of enzyme and sensing characteristics. According to experiential results, the average sensit
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WU, CIAN-YI, and 吳芊嬑. "Investigation on Sensing Characteristics and Stability of Arrayed Flexible Glucose and Urea Biosensor Based on TiO2 and NiO Films Modified by Magnetic Beads and Graphene Oxide, and Integrated with Microfluidic Framework and Real-Time Sensing System." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/3v4kj4.

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碩士<br>國立雲林科技大學<br>電子工程系<br>106<br>In this thesis, two kinds of metal oxide were proposed as martrix for flexible arrayed urea biosensor. The metal oxide films were Nickel Oxide (NiO) and Titanium dioxide (TiO2), respectively. The radio frequency sputtering system deposits the sensing film, and the screen printing technology were used to prepare the conductive arrayed wires and the reference electrode, and the epoxy is to encapsulate flexible arrayed urea biosensor. However, the covalent binding method is used to immobilize the enzyme between the matrix of the urea biosensor, and the preparatio
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Wu, You-Xiang, and 吳友祥. "The Research of Differential Reference Electrode Integrated with Magnetic Beads and Graphene Oxide Modified Arrayed Flexible IGZO/Al Ascorbic Acid Biosensor Based on Microfluidic Framework as well as Measurements for Sensing Characteristics, Equivalent Circuit and Real-time Sensing System." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/ktdemv.

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碩士<br>國立雲林科技大學<br>電子工程系<br>106<br>In this thesis, the screen-printed technology, radio frequency sputtering system and thermal evaporation system were used to integrate indium gallium zinc oxide (IGZO) membrane, Al electrode and silver paste onto the PET (polyethylene terephthalate) substrate. Next, the covalent bonding was used to immobilize ascorbate oxidase (AOX) onto the IGZO sensing membrane, and the flexible arrayed enzymatic L-ascorbic acid (L-AA) biosensor was completed. Besides, the graphene oxide (GO) and magnetic beads (MBs) were used to modify IGZO sensing membrane, and the electro
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